From Peptides to Mimetics: Towards Smaller More Stable Drug-like Protein-protein Interaction Inhibitors
Lead Research Organisation:
University of Bath
Department Name: Biology and Biochemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Brennan A
(2022)
The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist.
in Cell reports. Physical science
Brennan A
(2020)
Selective antagonism of cJun for cancer therapy
in Journal of Experimental & Clinical Cancer Research
Brennan A
(2022)
An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity.
in JACS Au
Hoang H
(2020)
Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides
in Chemical Science
Leech J
(2022)
In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun
in Journal of Biological Chemistry
Madden SK
(2021)
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.
in Molecular cancer
Meade RM
(2021)
A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding.
in Journal of molecular biology
Nadal-Bufi F
(2021)
Designed ß-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity.
in Journal of medicinal chemistry
Nadal-Bufí F
(2022)
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation.
in Cellular and molecular life sciences : CMLS
| Description | Invited speaker at 11th annual conference of the International Chemical Biology Society (ICBS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | https://icbs2022.chemical-biology.org/invited-speakers |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://icbs2022.chemical-biology.org/invited-speakers |