Taiwan Partnering Award: Investigation of proteins involved in African swine fever virus entry for vaccine development
Lead Research Organisation:
The Pirbright Institute
Department Name: African Swine Fever Virus
Abstract
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| Description | Research materials and knowledge on African swine fever virus have been exchanged between Pirbright Institute and Academica Sinica Taipei Taiwan as part of this collaborative project. Recombinant ASFV proteins proposed to be involved in virus entry were expressed using an insect virus baculovirus and mammalian vaccinia virus vectors. These recombinant proteins were tested and shown to be recognized by sera from pigs immunized with candidate ASFV live attenuated vaccines. Antisera raised in rabbits or mice were tested for ability to neutralise ASFV infection in porcine macrophages. Weak neutralization was observed with sera raised against against a proposed entry fusion complex protein. |
| Exploitation Route | Applications for future funding and exchange of researchers |
| Sectors | Agriculture, Food and Drink |
| Description | Materials have been sent from Pirbright to Academica Sinica Taipei Taiwan as part of the collaboration and from Academia Sinica Taipei to Pirbright. Due to Covid exchange visits have not been possible |
| First Year Of Impact | 2020 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal,Policy & public services |
| Description | Taiwan Partnering |
| Organisation | Institute of Molecular Biology, Academia Sinica |
| Country | Taiwan, Province of China |
| Sector | Public |
| PI Contribution | My Team provide expertise and licensed facility in High Containment to study African swine fever virus biology, diagnosis and vaccines |
| Collaborator Contribution | The Taiwan Team bring expertise in virus entry mechanisms, Vaccinia virus, protein expression |
| Impact | Multi-disciplinary: Virology, cell biology, immunology |
| Start Year | 2019 |