Taiwan Partnering Award: Artificial intelligence applications to identify regulatory genomic signatures of diet and lifestyle disease risk factors
Lead Research Organisation:
King's College London
Department Name: Genetics and Molecular Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Jordana Bell (Principal Investigator) | |
| Sarah Berry (Co-Investigator) |
Publications
Xia Y
(2021)
DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies.
in Clinical epigenetics
Costeira R
(2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
in Clinical Epigenetics
Hellbach F
(2023)
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
in European journal of nutrition
Villicaña S
(2023)
Genetic impacts on DNA methylation help elucidate regulatory genomic processes.
in Genome biology
Christiansen C
(2022)
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers
in Genome Medicine
Wielscher M
(2022)
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
in Nature communications
Karabegovic I
(2021)
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.
in Nature communications
| Description | The UK-Taiwan award analyses a subset of the data generated in the DIMENSION project. The key findings to date contributed to a publication on epigenetic signatures of caffeine intakes (Karabegovic et al. 2021). On-going work includes epigenetic exploration of B-vitamins intake and dynamic diet-epigenetic links related to the postprandial response. |
| Exploitation Route | Basis of diet biomarkers, as well as basis for validation and replication studies, and for future experimental work on the molecular signatures of nutrition. |
| Sectors | Agriculture, Food and Drink,Healthcare |
| Description | "Genetic impacts on human methylome variation", CANSSI Ontario STAGE program International Speaker Seminar Series, Toronto, Canada, November 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at an international seminar series host by University of Toronto |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Genetic impacts on human methylome variation", Epigenetic Inheritance Symposium, ETH Zurich, Switzerland, August 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at a symposium on epigenetics |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Genetic impacts on human methylome variation", FASEB conference "The Epigenome in Human Health and Diseases", University of Lorraine, October 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at an international conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Twin studies for epigenomic markers in obesity", European Association for the Study of Obesity (EASO)'s 28th annual European Congress on Obesity (ECO2021), May 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at a scientific conference on obesity |
| Year(s) Of Engagement Activity | 2021 |
| Description | Diet and the human methylome: towards improvement of cardio-metabolic health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the seminar series 'Paediatric Allergy and Nutrition Research' across multiple departments at King's College London, March 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Genetic impacts on DNA methylation levels in the context of DOHAD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the international DOHAD congress, Vancouver, August 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genetic impacts on DNA methylation variance (XZ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Selected oral presentation at the FASEB conference on The Epigenome in Human Health and Diseases, University of Lorraine, France, November 2021. Zhang* and Bell. Genetic impacts on DNA methylation variance |
| Year(s) Of Engagement Activity | 2021 |
| Description | Human DNA methylation trajectories of the postprandial metabolic response to food (RC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Selected talk at the 22nd International Congress of Nutrition (22nd IUNS-ICN) - in Tokyo, Japan. December 2022: Ricardo Costeira*, Lidia Daimiel Ruiz, Lucy Sinke, Colette Christiansen, Bastiaan Heijmans, Eline Slagboom, Melanie Waldenberger, Sarah Berry, José M Ordovás, Jordana T Bell. Human DNA methylation trajectories of the postprandial metabolic response to food. |
| Year(s) Of Engagement Activity | 2022 |