Development and analysis of technologies for measurement of protein interactions in living cells
Lead Research Organisation:
University of Manchester
Department Name: Life Sciences
Abstract
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Organisations
People |
ORCID iD |
| Michael White (Principal Investigator) |
Publications
Awais M
(2011)
Illuminating intracellular signaling and molecules for single cell analysis.
in Molecular bioSystems
| Description | This was a travel grant rather than a project grant. The work led to a new understanding of the mechanism of bioluminescence in living cells and also developed a new systems biology link |
| Exploitation Route | There is a continuing collaboration with Japan. Since the grant finished two Japanese students have come over to train in Manchester |
| Sectors | Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Ths project was a partnership with the laboratory of Dr Ozawa in Tokyo. It allowed several staff to travel to Japanand in return Japanese scientists made several trips to the UK. These included two 6 week student secondments from Japan with a third planned in 2015. the collaboration with the Japanese group is continuing and M. White travels to Japan at end November 2014. The work concentrated on sharing expertise on a number of technologies for protein interactions and on luciferase imaging technology. There have been multiple exchanges of reagents. the Japanese group are developing tools to study NF-kB signalling and helped the UK team to develop an optical switch system to study the cellular response to viruses. through the project each group has established other new contacts and collaborations (Ozawa with Sutton-Liverpool, Sanderson-Liverpool, Lucas-Manchester, Papalopulu-Manchester; White with Ohmiya-AIST, Kuroda-Univ of Tokyo and Kageyama-Kyoto) |
| First Year Of Impact | 2011 |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural,Economic |
| Description | Member and deputy chair of UKRI Future Leaders Fellowship panel involvement in 3 sift and 2 interview committees from 2018 - 2021) |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Award of Fellowships for training of future leaders |
| URL | https://www.ukri.org/funding/funding-opportunities/future-leaders-fellowships/ |
| Description | Member of BBSRC LoLa oanel |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://bbsrc.ukri.org/funding/filter/lola/ |
| Description | Member of joint research council tecnology touching life advisory group |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://www.ukri.org/research/themes-and-programmes/technology-touching-life/ |
| Description | A "Molecular Imaging (FLIM/FCS) toolbox" to investigate molecular interactions and activation in super-resolution and widefield mode |
| Amount | £255,000 (GBP) |
| Funding ID | 202923/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 10/2020 |
| Description | An upright confocal microscope for multidisciplinary research |
| Amount | £282,781 (GBP) |
| Funding ID | BB/R014361/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 04/2019 |
| Description | Strategic Lola |
| Amount | £4,160,524 (GBP) |
| Funding ID | BB/K003097/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2013 |
| End | 04/2018 |