Signalling events that regulate Wallerian degeneration

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

Axons are the long fibres that connect one nerve cell with another and carry electrical communication between them. If these fibres degenerate, nervous function ceases resulting in neurodegenerative diseases such as Alzheimer's disease, motor neuron disease and multiple sclerosis. In many nervous disorders, the degeneration of the fibres precedes death of the cell from which they arise, but in the central nervous system the fibres cannot regenerate even if the cell survives. Thus, it is essential to understand and eventually intervene in axon degeneration mechanisms. We have identified a gene that can delay axon degeneration tenfold in mice, rats and flies, and have now found a chemical treatment that blocks its action. The aim of this project is to understand the basis of this block, and to shed light on how one part of a nerve cell signals to other parts that damage has taken place.

Publications

10 25 50
 
Description We tested whether kinase inhibitors would influence axon survival
Exploitation Route We excluded the hypothesis that ERK signalling influences axon preservation by WLDS and decided it was important to follow a different route.
Sectors Healthcare