Computational systems biology of ageing in haematopoiesis and the immune system

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

Ageing is a multidimensional process associated with decline in many physical and psychological functions. These life changes have their origin in our genomes, and are influenced by diet, life-style and the environment. One of the key changes associated with ageing that seriously affects the health of the elderly is a decrease in the functioning of the immune system. The immune system normally works to fight infections to keep us healthy. However, the immune system in the elderly is less active, leaving them much more prone to infection and resulting in deterioration in the quality of life in later years and in many cases early death. In this project we will apply powerful new genome-wide technologies to measure many of the effects of ageing in mouse blood cells, with a particular focus on B cells, the blood cells that make antibodies and form a major part of the immune system. We will use this information to identify specific genes whose expression or function is altered in cells from aged mice, and which may be contributing to a deterioration in immune cell function in the elderly. We will then attempt to change the expression of some of these key ageing-related genes experimentally, to determine their role in acceleration or delay of the ageing process and immune system function. A potential impact of this work is an extension of the healthy life span, by providing new information and understanding of the processes of ageing in immune cells and other cells of the blood.

Publications

10 25 50
 
Title CHROMOS 
Description A creative collaboration with electronic musician Max Cooper and video artist Andy Lomas on a music video and a virtual reality exhibit illustrating the 3D structure of DNA based on real data arising from single-cell Hi-C assay. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2017 
Impact The music video and virtual reality exhibit were showcased at Cambridge Science Festival, Science Museum Lates (London), and ZKM Open Codes exhibition (Karlsruhe, Germany), with plans for further appearances. The music video forms part of Max Cooper's Emergence project that he performs throughout the world to high critical acclaim (see, e.g., coverage in the Wired magazine - http://www.wired.co.uk/article/max-coopers-science-inspired-music-will-blow-your-mind). 
URL https://www.youtube.com/watch?v=oyxwoLHFv_U
 
Description We have used an integrative genome-wide approach to determine changes in gene regulation and nuclear organisation that may help to explain why B lymphocytes in the aged bone marrow proliferate poorly and produce a poor antibody repertoire, contributing to impaired response to infection in the elderly.

We have found that a key signalling pathway, the insulin-like growth factor receptor pathway, is impaired in aged progenitor B cells. Importantly this impaired occurs at multiple epigenetic loves. Increased repressive histone modifications and decreased activating histone modifications at promoters, increased antagonistic microRNAs, and decreased interactions of key IGF1r signalling genes, combine to reduce expression of these genes. This may be a key contributor to loss of B cells in ageing. This research has been published in Genome Biology in 2018.
High throughput computational algorithrms for the analysis and interpretation of promoter capture HiC data.
Exploitation Route Our findings provide a comprehensive dataset of all the genes up and down regulated in ageing B cells. We are following up the Igf1r signalling pathway, but there are several other dysregulated pathways that could be explored by others for greater understanding and to take forward to clinical intervention studies.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description BBSRC AMRWG
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description CaSE Opinion Forum invitation: the impact of immigration on science and engineering
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Management Board of shARM (sharing Ageing Research Models)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Provision of a not for profit Biobank of aged mouse tissues to the ageing mouse research community
URL https://www.sharmuk.org
 
Description member of BBSRC Tools and Resources Development Fund (TRDF1) review panel
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description BBSRC DTP
Amount £120,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2013 
End 10/2017
 
Description BBSRC DTP iCASE
Amount £105,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description BBSRC iCASE PhD studentships
Amount £98,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2014 
End 09/2018
 
Description International postdoctoral fellowship
Amount 3,500,000 kr (SEK)
Organisation Swedish Research Council 
Sector Public
Country Switzerland
Start 01/2014 
End 01/2017
 
Description MRC DTP
Amount £120,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 04/2019
 
Description National Productivity ad Investment Fund studentship
Amount £120,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 03/2021
 
Description University of Cambridge Doctoral Training Programme
Amount £120,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 03/2023
 
Title CHiCAGO 
Description The CHiCAGO computational pipeline for Capture Hi-C data analysis. 
Type Of Material Computer model/algorithm 
Year Produced 2015 
Provided To Others? Yes  
Impact Our computational pipeline is published (Cairns et al., Genome Biology 2016) and publicly available as an open source R package Chicago on Bioconductor and bitbucket. It has become a de-facto standard for Capture Hi-C data analysis and has an active user base internationally. 
URL http://regulatorygenomicsgroup.org/chicago
 
Description Bertie Gottgens collab 
Organisation University of Cambridge
Department Cambridge Institute for Medical Research (CIMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed promoter capture Hi-C
Collaborator Contribution Other experiments and analyses.
Impact Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model NK Wilson, S Schoenfelder, R Hannah, MS Castillo, J Schütte, ...(2016) Blood, blood-2015-10-677393
Start Year 2012
 
Description Bertie Gottgens collab 
Organisation University of Cambridge
Department Department of Haematology
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed promoter capture Hi-C
Collaborator Contribution Other experiments and analyses.
Impact Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model NK Wilson, S Schoenfelder, R Hannah, MS Castillo, J Schütte, ...(2016) Blood, blood-2015-10-677393
Start Year 2012
 
Description Collab with CW 
Organisation University of Cambridge
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Conceptualisation, methodology and analysis of Capture Hi-C data.
Collaborator Contribution Statistical analysis and visualisation tools for Capture Hi-C data.
Impact Within the scope of this grant, the CHiCP tool and two papers (submitted and in preparation). Interdisciplinary collaboration (statistics/biology). Jointly presented our work on Cambridge TV.
Start Year 2015
 
Description Collab with DZ 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Method development and analysis of Capture Hi-C data.
Collaborator Contribution Integration of Capture Hi-C data with Ensembl regulatory build; statistical advice.
Impact Within the scope of this grant, the Chicago computational pipeline for Capture Hi-C data.
Start Year 2015
 
Description Collab with PRG 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Analysis and conceptualisation of Capture Hi-C data.
Collaborator Contribution Generation of human ES cells and ES-derived progenitors, stem cell expertise.
Impact Freire-Pritchett et al., eLife 2017.
Start Year 2013
 
Description Collab with VP 
Organisation University College London
Department Genetics Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of computational tools for Capture Hi-C data analysis.
Collaborator Contribution Statistical advice on Capture Hi-C data analysis.
Impact Cairns et al., Genome Biology 2016.
Start Year 2013
 
Description Collaboration with Elderkin 
Organisation Agilent Technologies
Country United States 
Sector Private 
PI Contribution Performed Promoter capture Hi-C and other experiments with collaborating team, shared in analysis and interpretation.
Collaborator Contribution Performed other experiments with collaborating team, shared in analysis and interpretation.
Impact Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome S Schoenfelder, R Sugar, A Dimond, BM Javierre, H Armstrong, B Mifsud, et al., Nature Genetics 47,1179-1186 (2015)
Start Year 2012
 
Description Collaboration with Elderkin 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Performed Promoter capture Hi-C and other experiments with collaborating team, shared in analysis and interpretation.
Collaborator Contribution Performed other experiments with collaborating team, shared in analysis and interpretation.
Impact Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome S Schoenfelder, R Sugar, A Dimond, BM Javierre, H Armstrong, B Mifsud, et al., Nature Genetics 47,1179-1186 (2015)
Start Year 2012
 
Description Collaboration with Elderkin 
Organisation Cancer Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Performed Promoter capture Hi-C and other experiments with collaborating team, shared in analysis and interpretation.
Collaborator Contribution Performed other experiments with collaborating team, shared in analysis and interpretation.
Impact Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome S Schoenfelder, R Sugar, A Dimond, BM Javierre, H Armstrong, B Mifsud, et al., Nature Genetics 47,1179-1186 (2015)
Start Year 2012
 
Description Collaboration with Elderkin 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed Promoter capture Hi-C and other experiments with collaborating team, shared in analysis and interpretation.
Collaborator Contribution Performed other experiments with collaborating team, shared in analysis and interpretation.
Impact Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome S Schoenfelder, R Sugar, A Dimond, BM Javierre, H Armstrong, B Mifsud, et al., Nature Genetics 47,1179-1186 (2015)
Start Year 2012
 
Description Collaboration with Elderkin 
Organisation RIKEN
Department RIKEN Center for Developmental Biology
Country Japan 
Sector Public 
PI Contribution Performed Promoter capture Hi-C and other experiments with collaborating team, shared in analysis and interpretation.
Collaborator Contribution Performed other experiments with collaborating team, shared in analysis and interpretation.
Impact Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome S Schoenfelder, R Sugar, A Dimond, BM Javierre, H Armstrong, B Mifsud, et al., Nature Genetics 47,1179-1186 (2015)
Start Year 2012
 
Description Collaboration with Olivia Fletcher et al 
Organisation Institute of Cancer Research UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed capture Hi-C with collaborators
Collaborator Contribution Performed capture Hi-C and data analyses.
Impact Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci R Jäger, G Migliorini, M Henrion, R Kandaswamy, HE Speedy, A Heindl, ...(2015) Nature communications 6, Article number: 6178 Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C NH Dryden, LR Broome, F Dudbridge, N Johnson, N Orr, S Schoenfelder, ...(2014) Genome research 24 (11), 1854-1868
Start Year 2010
 
Description Collaboration with Olivia Fletcher et al 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Performed capture Hi-C with collaborators
Collaborator Contribution Performed capture Hi-C and data analyses.
Impact Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci R Jäger, G Migliorini, M Henrion, R Kandaswamy, HE Speedy, A Heindl, ...(2015) Nature communications 6, Article number: 6178 Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C NH Dryden, LR Broome, F Dudbridge, N Johnson, N Orr, S Schoenfelder, ...(2014) Genome research 24 (11), 1854-1868
Start Year 2010
 
Description Collaboration with Olivia Fletcher et al 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed capture Hi-C with collaborators
Collaborator Contribution Performed capture Hi-C and data analyses.
Impact Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci R Jäger, G Migliorini, M Henrion, R Kandaswamy, HE Speedy, A Heindl, ...(2015) Nature communications 6, Article number: 6178 Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C NH Dryden, LR Broome, F Dudbridge, N Johnson, N Orr, S Schoenfelder, ...(2014) Genome research 24 (11), 1854-1868
Start Year 2010
 
Description Manchester RA collaboration 
Organisation University of Cambridge
Department Cambridge Institute for Medical Research (CIMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed Capture Hi-C with collaborators
Collaborator Contribution Performed Capture Hi-C and other experiments and analyses
Impact Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci (2015) Paul Martin, Amanda McGovern, Gisela Orozco, Kate Duffus, Annie Yarwood, Stefan Schoenfelder, Nicholas J Cooper, Anne Barton, Chris Wallace, Peter Fraser, Jane Worthington, Steve Eyre. Nature Communications 6, Article number: 10069
Start Year 2011
 
Description Manchester RA collaboration 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Public 
PI Contribution Performed Capture Hi-C with collaborators
Collaborator Contribution Performed Capture Hi-C and other experiments and analyses
Impact Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci (2015) Paul Martin, Amanda McGovern, Gisela Orozco, Kate Duffus, Annie Yarwood, Stefan Schoenfelder, Nicholas J Cooper, Anne Barton, Chris Wallace, Peter Fraser, Jane Worthington, Steve Eyre. Nature Communications 6, Article number: 10069
Start Year 2011
 
Description Manchester RA collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Performed Capture Hi-C with collaborators
Collaborator Contribution Performed Capture Hi-C and other experiments and analyses
Impact Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci (2015) Paul Martin, Amanda McGovern, Gisela Orozco, Kate Duffus, Annie Yarwood, Stefan Schoenfelder, Nicholas J Cooper, Anne Barton, Chris Wallace, Peter Fraser, Jane Worthington, Steve Eyre. Nature Communications 6, Article number: 10069
Start Year 2011
 
Description PCHiC with Osborne 
Organisation Babraham Institute
Department Nuclear Dynamics ESP
Country United Kingdom 
Sector Academic/University 
PI Contribution We performed promoter capture Hi-C with the collaborating lab and shared in analysis and interpretation.
Collaborator Contribution performed promoter capture Hi-C with the collaborating lab and shared in analysis and interpretation.
Impact Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C B Mifsud, F Tavares-Cadete, AN Young, R Sugar, S Schoenfelder, et al., Nature genetics 47 (6), 598-606
Start Year 2010
 
Title Method of identifying VDJ recombination products 
Description A high-throughput, high resolution DNA-based next generation sequencing assay to interrogate the sequences of VDJ recombined gene products resulting from antigen receptor recombination. Patent licence granted in USA and Europe in 2017. Licence application pending in Japan. Undertaking active marketing, no commercial licensee finalised as yet. 
IP Reference EP2820153 
Protection Patent granted
Year Protection Granted 2017
Licensed No
Impact Collaborations with academic, clinical and commercial interests, resulting in 3 grant applications, one of which was successful
 
Description 'Making your mark' epigenetics exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact An epigenetics exhibit was designed and produced to explain the role of histone modifications in epigenetic regulation of gene expression. It was displayed at the Hills Road Sixth Form College Cambridge Big Biology Day October 2017, which resulted in positive feedback and a plan to exhibit this at the Cambridge science festival in 2018
Year(s) Of Engagement Activity 2017
 
Description B lymphocyte development lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact 60 Cambridge University undergraduate medical, veterinary and natural science students attended the lecture on B lymphocyte development, which sparked many questions afterwards. Supervision sessions were also conducted on the topic, essays assessed, and exam questions submitted.

Numerous students asked for tutorials on the lecture, emailed queries about the topic, wrote essays, and the majority of students attempted the question on this topic when it came up in the exam. The lecture was rated by the students as 'excellent'. Several requests were made to do a summer project in our lab.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description Babraham Institute Schools Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 12 GCSE and A level students spent a day in our lab, doing a small project. Many asked questions about our research and careers in biology. Positive feedback relayed after the visit by teachers.

The feedback afterwards from the students was that biological research was more interesting and scientists more normal than the students expected.
Year(s) Of Engagement Activity 2010,2011,2013,2014,2015
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We developed exhibits that explained epigenetics, the immune system and how ageing affects this, and key displays of the research the Institute does. We provided take-home resources and quizzes and received very positive feedback.
Year(s) Of Engagement Activity 2013,2014,2015
 
Description Cambridge Science Festival 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Participated in Cambridge Science Festival evening. Answered questions and engaged in general discussion about our science with general public at the Babraham stand.
Year(s) Of Engagement Activity 2015
URL http://www.sciencefestival.cam.ac.uk/about/past-festivals/2015-cambridge-science-festival
 
Description FindaPhD.com YouTube 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Made a short video for FindaPhD.com as part of a series of inspirational interviews with senior group leaders about their own PhDs. FindaPhD launched this on International Women's Day as a YouTube video, and on their website, Twitter, Facebook. Dozens of positive comments on Twitter and Facebook worldwide within 24 hours, as well as personal requests for advice about PhDs
Year(s) Of Engagement Activity 2018
URL https://youtu.be/PDu5y4s8hGQ
 
Description ImmuneArmy YouTube video 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact We made a video called Immune Army which details in cartoon format the various soldiers in the immune army and how research at Babraham contributes to our understanding of the immune system and how it ages. This formed part of the Immune Army website, which also contains other resources that we created for schools and the general public, including a jigsaw and an iPAD game for understanding immunoglobulin V(D)J recombination
Year(s) Of Engagement Activity 2015
URL http://immunearmy.babraham.ac.uk
 
Description Mosaic magazine article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Article by Tom Chivers "How Big Data is Changing Science" including interviews with me and other genomics scientists, giving our perspectives on the explosion of big data science in recent year and the opportunities and challenges this brings. The aim was to illustrate the rapidly changing skill sets needed to understand big data, which senior scientists have not learned and need to keep up with.
Year(s) Of Engagement Activity 2008,2016,2018
 
Description Primary School visits 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact Visits were made to a local school. 60 Year 4 to 6 primary school children attended presentations and hands-on practical related to our science.

The teachers reported an increase in understanding and interest in biological research and what real scientists do. We are frequently requested to visit.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description Royal Society exhibit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The exhibit was called the Immune Army, and showcased a variety of studies that Babraham researchers are carrying out to understand a variety of cell types in the immune system, how they work together to fight infection, and how this ability to fight infection is impaired as we age. We explained that our aim was ultimately to find ways to help people to age more healthily. The exhibit sparked many questions about the ageing process and how the public can slow down loss of immune function. It prompted a visit by James Gallagher, Health Editor for the BBC, to see what science Babraham is doing.
Year(s) Of Engagement Activity 2015
 
Description STEM teachers visit to lab 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Three secondary school teachers spent the day in the lab, performing experiments, hearing about our research
Year(s) Of Engagement Activity 2016
 
Description Schools Day 2015 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 10 pupils visited my lab for morning or afternoon of hands on experiments. Lots of questions and discussions and pupils had a chance to meet real scientists. School reported increased interest in subject area.
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
 
Description Schools day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact School children were engaged in science

Members of the group reported back that the project was excellent and that it had made them very interested in research biology
Year(s) Of Engagement Activity 2010,2011,2012,2014
 
Description Science Museum Lates 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact We brought the CROMOS project (see Artwork) to Science Museum Lates in Sep 2017, which was one of the most popular exhibits at the event.
Year(s) Of Engagement Activity 2017
URL https://www.facebook.com/events/1125793267522307/
 
Description TV press release for Nature Genetics paper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview with Cambridge TV relating to Nature Genetics paper release
Year(s) Of Engagement Activity 2015
URL http://www.cambridge-tv.co.uk/Stem-Cells/
 
Description Teachers visit to the Lab 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 2 Teachers applied to visit the lab for a day.
Year(s) Of Engagement Activity 2016
 
Description The Role of polycomb repressive complex in nuclear organisation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talked which was followed by questions

NA
Year(s) Of Engagement Activity 2013
 
Description Visit to the lab by a 6th form student who won the winner of the RCUK Best Use of Research prize http://www.rcuk.ac.uk/media/news/150317/ 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Maria visited the lab for a morning and performed a number of experiments in the lab
Year(s) Of Engagement Activity 2015
 
Description You Tube video on Nature Genetics paper 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A video explaining our recent publication
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=3JOcGUMbipI
 
Description media interest 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Publication of paper in Frontiers in Immunology and press release resulted in 3 news articles - in Medindia, Labonline (Australia), Health Canal
Year(s) Of Engagement Activity 2017
 
Description visit to special needs school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a talk to a class of children with learning difficulties on the fun aspects of science

After my talk the children were engaged in science activities more.
Year(s) Of Engagement Activity 2012