To study epigenetic mechanisms regulating lineage commitment and cell potency
Lead Research Organisation:
Babraham Institute
Department Name: UNLISTED
Abstract
This objective is a natural progression of our previous ISPG in which we have successfully established epigenomic profiles across a vast array of developmental stages during germ cell as well as pre- and post-implantation development, and of related stem cell types. We shall build on these advances and address key questions arising: notably, how are distinct, cell type-defining epigenetic patterns established at the mechanistic level to cement cell fate specification and, conversely, what are the critical chromatin features that enable the reversal to totipotency? Mathematical modelling integrating transcriptional, epigenetic and metabolic states will provide a quantitative mechanistic understanding of the control mechanisms underlying toti-/pluripotency, self-renewal and lineage differentiation pathways. Developmental progression is characterised by the transition of cellular plasticity from a totipotent zygote to the emergence of the first cell lineages at the blastocyst stage and ultimately the differentiation into highly specialised cell types. These steps are underpinned by the acquisition of epigenetic marks that help define, and lock in, cell fate. As such, totipotency is an ephemeral state intrinsic only to the fertilised zygote and 2-cell stage embryo, and describes the widest-possible plasticity of a cell to differentiate into all embryonic as well as extra-embryonic cell types. Despite its importance, little is known regarding the molecular mechanisms regulating this state, mostly due to limited and hard-to-obtain samples. However, the recent identification of a small subpopulation of embryonic stem cells (ESCs) that exhibits totipotent features (so-called 2C-like cells), together with transformative advances in single-cell technologies, has opened up this field to mechanistic investigations. Leading on from this, our work has shown that the timing of lineage commitment coincides perfectly with the onset of de novo DNA methylation, and results in the establishment of lineage-defining epigenomic patterns and hallmarks1-3. We have also explored how the epigenome integrates with the transcriptional landscape and how it is influenced by signalling pathways4,5. With this in-depth knowledge, a critical question is how the epigenetic machinery is targeted to different genomic sites to set up lineage-distinctive and cell potency-defining patterns. In parallel with experimental efforts, we will expand our modelling approaches of the first cell fate decision by integrating transcriptional, epigenetic as well as metabolic data to gain qualitative and quantitative insights into the regulators governing totipotency and cellular differentiation. Cellular metabolism is known to differ between the first cell lineages, in particular lipid metabolism, and metabolic state is recognised as an important modulator of cell plasticity that may thereby impact on the epigenome. Thus, integration of cell metabolic states into mathematical models, in parallel to our experimental efforts, will advance our understanding of how the epigenome is shaped to promote self-renewal and underpin the first cell fate decision events. This Objective involves close cross-ISP interactions with the Signalling ISP in relation to trophoblast stem cells (TSCs) and modelling of metabolic effects on epigenetic regulators on cell-fate decisions.
Organisations
- Babraham Institute, United Kingdom (Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- Max Planck Society (Collaboration)
- Karolinska Institute, Sweden (Collaboration)
- University of Dundee, United Kingdom (Collaboration)
- Active Motif (Collaboration)
- Harvard University (Collaboration)
- Queen Mary, University of London, United Kingdom (Collaboration)
- University of Cambridge (Collaboration)
- National Institute of Environmental Health Sciences (Collaboration)
- University of Cantabria, Spain (Collaboration)
- Cancer Research Technology (CRT) (Collaboration)
- Francis Crick Institute (Collaboration)
- Cambridge Epigenetix (Collaboration)
- RIKEN, Japan (Collaboration)
Publications
Alda-Catalinas C
(2020)
A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program.
in Cell systems
Andrews PW
(2017)
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
in Stem cell reports
Antunes C
(2021)
Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice.
in Molecular psychiatry
Argelaguet R
(2019)
Multi-omics profiling of mouse gastrulation at single-cell resolution.
in Nature
Carucci N
(2017)
Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis.
in Royal Society open science
Chrysanthou S
(2018)
A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells.
in Stem cell reports
Collier AJ
(2017)
Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States.
in Cell stem cell
Collins JE
(2019)
Common and distinct transcriptional signatures of mammalian embryonic lethality.
in Nature communications
Eckersley-Maslin M
(2019)
Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.
in Genes & development
Eckersley-Maslin M
(2018)
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
in Nature Reviews Molecular Cell Biology
Eckersley-Maslin MA
(2020)
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
in Nature structural & molecular biology
Freire-Pritchett P
(2017)
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.
in eLife
Gao X
(2019)
Establishment of porcine and human expanded potential stem cells.
in Nature cell biology
Gdula MR
(2019)
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.
in Nature communications
Hanna CW
(2017)
Genomic imprinting beyond DNA methylation: a role for maternal histones.
in Genome biology
Hastings J
(2017)
WormJam: A consensus C. elegans Metabolic Reconstruction and Metabolomics Community and Workshop Series
in Worm
Kubinyecz O
(2021)
Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
in Development (Cambridge, England)
Lee CQE
(2019)
Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast.
in Stem cells (Dayton, Ohio)
Lee CQE
(2018)
Integrin a2 marks a niche of trophoblast progenitor cells in first trimester human placenta.
in Development (Cambridge, England)
Lohoff T
(2022)
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis.
in Nature biotechnology
López-Tello J
(2019)
Fetal and trophoblast PI3K p110a have distinct roles in regulating resource supply to the growing fetus in mice.
in eLife
Mohammed H
(2017)
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.
in Cell reports
Montalbán-Loro R
(2019)
TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn.
in Nature communications
Olan I
(2020)
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence.
in Nature communications
Parry A
(2021)
Active turnover of DNA methylation during cell fate decisions.
in Nature reviews. Genetics
Perez-Garcia V
(2021)
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
in eLife
Pijuan-Sala B
(2019)
A single-cell molecular map of mouse gastrulation and early organogenesis.
in Nature
Raiber EA
(2018)
5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells.
in Nature chemistry
Rugg-Gunn PJ
(2022)
Induction of Human Naïve Pluripotency Using Chemical Resetting.
in Methods in molecular biology (Clifton, N.J.)
Rugg-Gunn PJ
(2017)
Naive pluripotent stem cells as a model for studying human developmental epigenomics: opportunities and limitations.
in Epigenomics
Santiago M
(2020)
Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.
in Cellular and molecular life sciences : CMLS
Schoenfelder S
(2018)
Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages.
in Nature communications
Stuart HT
(2019)
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
in Cell stem cell
Thiecke MJ
(2020)
Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.
in Cell reports
Turco M
(2018)
Trophoblast organoids as a model for maternal-fetal interactions during human placentation
in Nature
Vasiliauskaite L
(2018)
Defective germline reprogramming rewires the spermatogonial transcriptome.
in Nature structural & molecular biology
Wojdyla K
(2020)
Cell-Surface Proteomics Identifies Differences in Signaling and Adhesion Protein Expression between Naive and Primed Human Pluripotent Stem Cells.
in Stem cell reports
Woods L
(2017)
Decidualisation and placentation defects are a major cause of age-related reproductive decline.
in Nature communications
| Description | We have made significant progress in our aim to dissect the molecular mechanisms and players that control totipotency and cell fate decision-making during early mammalian development. We discovered Dppa2 and Dppa4 as new positive regulators of 2C like cells and zygotic genome activation (ZGA; PMID 30692203). We showed that loss of DNA methylation at the Dppa2 and Dppa4 promoters temporally correlates with Dppa2 and Dppa4 expression (Objective 1.1.1). Further, Dppa2/4 directly bind to the Dux promoter to induce Dux expression. This establishes a 2C-like transcription programme that is subsequently stabilised by Zscan4c. We have now made conditional knockouts of both genes in oocytes; surprisingly we find that ZGA was not majorly affected but that maternal stores of these proteins have an important role in offspring survival, potentially via epigenetic priming of developmental genes (PMID 34931676). We further demonstrated that Dppa2/4 are important for priming of bivalent developmental genes in pluripotent cells. In the absence of Dppa2 and 4, bivalency in a subset of developmental promoters was lost and these promoters became DNA methylated and failed to be activated during differentiation (PMID: 32572255; Objective 1.1.2). To screen for novel activators of ZGA, we established a CRISPR activation screen coupled with a single cell transcriptome read-out (PMID 33899013). Together with known activators of ZGA our screen has identified several new and exciting candidates which we are currently testing in in vivo experiments (PMID: 32634384). In parallel experiments in human naïve ESCs, we have identified a subpopulation of cells that resemble transcriptionally and epigenetically 8-cell blastomeres from human embryos. This is the stage at which ZGA occurs in human embryos, and these 8-cell like cells (8-CLCs) may therefore constitute a useful in vitro system for the study of human ZGA (PMID 35216671). Expanded potential stem cells (EPSCs) possess developmental potency for all embryonic and extra-embryonic cell lineages. We helped to establish conditions to generate and stably maintain EPSCs from mouse, porcine and human cells, paving the way for systems approaches to dissect cell fate specification events during the earliest stages of mammalian development (PMID 31160711; Objective 1.1.2). By transcriptome profiling of over 100,000 individual cells, we have contributed to constructing a comprehensive, single cell-resolution atlas of transcriptional events that define cell states during early mouse development (PMID 30787436; Objective 1.2). Building on transformative methodology developed in our department, we have linked these transcriptional events to changes in chromatin accessibility and DNA methylation during embryonic cell lineage specification at single cell resolution (PMID 31827285; Objectives 1.2.1 and 1.2.2). This multi-omics profiling approach enabled us to dissect the cell state transitions during mouse gastrulation at unprecedented resolution. One of the key discoveries from this work was that DNA methylation and chromatin accessibility at ectodermal enhancers, but not endodermal and mesodermal enhancers, is already established in the early epiblast, revealing that the gene regulatory landscape is epigenetically primed or remodelled prior to cell fate decisions during gastrulation (PMID 31827285). Building on our expertise developed in this grant to isolate pure populations of human naïve and primed pluripotent stem cells, we have characterised, at the single-cell level, the expression signatures for both cell types representing key stages of early human embryonic development (PMID 30673604; Objective 1.2). We further found that surprisingly, cells can utilize distinct signalling pathways and transcription factor networks to acquire the naïve pluripotent state (PMID 31422912). Parallel single cell analysis and epigenetic profiling has revealed oscillatory dynamics during the exit from pluripotency (PMID 30031774), indicating that dynamic changes in DNA methylation might underpin cell fate decisions during early mammalian development (Objective 1.2). We have identified key functions for proteins in the self-renewal and differentiation of trophoblast stem cells, including TET (Ten-eleven-translocation) proteins (Objective 1.2). We uncovered a novel role for TET1/2 proteins in the control of trophoblast cell cycle progression (PMID 29576538), and in mediating trophoblast-specific long-range chromosomal interactions involved in the regulation of key trophoblast genes (PMID 30305613; Objective 1.2.2). Through a series of experiments focusing on the role of the cohesin complex in genome organisation, we have uncovered mechanisms of 3D genome folding that contribute to cell lineage specific transcription programmes (PMID: 32065581; PMID: 32698000; PMID: 33247104; Objective 1.2.2). We have characterised the transcriptome signatures of mouse knockout lines from the Deciphering the Mechanisms of Developmental Disorders programme to elucidate causes of embryonic lethality (PMID 31243271). Unexpectedly, we found that over two thirds of mouse lines that are lethal at or after mid-gestation exhibit abnormal placental morphologies. We demonstrated that unexpectedly, placental defects strongly correlate with defects in heart, brain and vascular development. Our data have thus uncovered a hitherto unrecognised contribution of placental abnormalities to embryonic development (PMID 29539633; Objective 1.2). Building on this work, we have identified BAP1 as a key regulator of trophoblast biology, finding that BAP1 downregulation is essential to induce the epithelial to mesenchymal transition during trophoblast differentiation (PMID 34170818). We have established a ground-breaking new method to maintain a trophoblast stem cell population from the human placenta in culture through adaptation and optimisation of organoid culture methods, opening new avenues to study human placental development (PMID 30487605; Objective 1.2.2). In addition, we identified critical signalling pathways affecting trophoblast lineage self-renewal and differentiation (PMID 31233251 and PMID 31241463; Objective 1.2.2). For another member of the TET family, TET3, we demonstrated an essential role in the maintenance of neural stem cell identity (PMID 30979904). We found that TET3 is necessary to maintain silencing of pluripotency genes including Oct4 and Nanog in neural precursor cells, possibly through regulation of DNA methylation levels (PMID 31160711; Objective 1.2.2). We have used the cutting-edge single cell methodology developed in our ISP to functionally characterise cell lineages during early mouse and human development. Building on our expertise developed in this grant to isolate pure populations of human naïve and primed pluripotent stem cells, we have characterised, at the single cell level, the expression signatures for both cell types representing key stages of early human embryonic development (PMID 30673604; Objective 1.2). We further found that surprisingly, cells can utilize distinct signalling pathways and transcription factor networks to acquire the naïve pluripotent state (PMID 31422912). We have characterised the transcriptome signatures of mouse knockout lines from the Deciphering the Mechanisms of Developmental Disorders programme to elucidate causes of embryonic lethality (PMID 31243271). Unexpectedly, we found that over two thirds of mouse lines that are lethal at or after mid-gestation exhibit abnormal placental morphologies. We demonstrated that unexpectedly, placental defects strongly correlate with defects in heart, brain and vascular development. Our data have thus uncovered a hitherto unrecognised contribution of placental abnormalities to embryonic development (PMID 29539633; Objective 1.2). |
| Exploitation Route | Our research is uncovering novel players that direct cellular plasticity and that underpin cell fate decisions in development, thereby advancing the 'Bioscience for Health' BBSRC priority. We are disseminating our research through scientific publications, presentations at international meetings and organisation of conferences (e.g. The Ageing Cell, 2017; ESHRE 2017; EMBL Mammalian Genetics and Genomics Meeting 2017; etc). We have also successfully run the "BBSRC collaborative workshop on Epigenetics" twice at our institute (November 2018 and February 2020). We are providing high-level training to others in using the technologies we developed and in the concepts we discovered, which fundamentally promotes the UK's reputation and standing in conducting pioneering science research. The Epigenetics ISP is showcasing its research at the Cambridge Science Festival and Royal Society Summer Festival (exhibit 'Race Against The Ageing Clock'). We are also contributing to the creation of an informed society through taking part in public events about epigenetics, development, stem cells, ageing, and gene editing (e.g. at the Cambridge Science Festival, in Q&A sessions with the public etc). |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | We have developed a Virtual Reality (VR) project that enables members of the public to experience the three-dimensional folding of DNA in the nucleus in a novel and 'hands-on' way. This project ('Chromos: A virtual DNA experience') has successfully featured during the Cambridge Science Festival in February 2017, at the London Science Museum Lates in September 2017, and in 2018 as part of the 'Open Codes' exhibit at ZKM (Centre for Art and Media) in Karlsruhe, Germany. For Chromos, 3D genome folding data generated at the Babraham Institute have been transformed into a VR experience (by visual artist and mathematician Andy Lomas), accompanied by a soundtrack composed by musician Max Cooper. Chromos allows people to interact with the data in a unique way by 'climbing inside the data'. Chromos has been very well received by members of the public, which convinced us that VR is an ideally suited medium to present and explain the significance of our research (in particular involving complex three-dimensional biological structures) to a wider public. It also presents a great opportunity for two-way engagement with the public, to capture their feedback. A public engagement seed fund prize from the Babraham Institute enabled us to further develop Chromos to visualise the dynamic changes in 3D genome organisation and enhancer rewiring during the transition from naïve to primed human pluripotent stem cells, key stages in early human development (based on data in PMID: 33828098; Objective 1.2). |
| First Year Of Impact | 2017 |
| Sector | Education,Healthcare |
| Impact Types | Societal |
| Description | CTR Board of Managers (MH) |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Member, Board of Managers of the Centre for Trophoblast Research, Cambridge assessing funding for targetted PhD studentship and Next Generation fellowship applciations and influencing science strategy within this research area. |
| Description | Chair of SAB Centre for Trophoblast Research University of Cambridge |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Has changed the perception of placenta and trophoblast in reproduction |
| Description | H2020 EU-LIFE project "LIBRA", co-lead work package "Gender Equality in Research" |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Consideration of gender effects in research, appreciation that there may be sex differences in cell lines, animal models and treatment regimes that ought to be taken into consideration when designing studies. |
| Description | Review panel member, DFG Clinical Research Unit (Germany) (MH) |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Funding assessment for a major research unit on male infertility which includes improvement of patient treatment options and better patient assessment and stratification. Funding was recommended by teh panel and was implemented. |
| Description | Steering board Human Cell Atlas |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Description | ERC Advanced grant |
| Amount | £2,200,000 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 01/2021 |
| End | 12/2026 |
| Description | Enhancer DNA methylation dynamics during early mammalian development |
| Amount | £300,000 (GBP) |
| Funding ID | 215912/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 08/2023 |
| Description | Flagship |
| Amount | € 1,000,000 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2019 |
| End | 03/2020 |
| Description | Investigator Award |
| Amount | £2,600,000 (GBP) |
| Funding ID | 210754/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2023 |
| Description | Special initiative |
| Amount | £10,000,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 04/2024 |
| Description | UKRMP2 Pluripotent Stem and Engineered Cell (PSEC) Hub |
| Amount | £250,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Wellcome collaborative award in science |
| Amount | £3,900,000 (GBP) |
| Funding ID | 220379/z/20/z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 11/2025 |
| Title | A protocol for high-throughput quantitative RT-qPCR in single C. elegans using nanofluidic technology |
| Description | high throughput protocol for fast and reliable determination of gene expression levels in single or pooled C. elegans samples utilizing nanofluidics real time polymerase chain reaction. |
| Type Of Material | Biological samples |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Help other C elegans reserachers with the measurement of rare transcripts from single worm samples. |
| Title | C elegans Metabolic Reconstruction Model |
| Description | Merged and re-annotated C elegans Metabolic Reconstruction Model |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This is a great improvement to the C elegans research community |
| Title | Crispr activation single cell transcriptome screen in mouse ES cells |
| Description | A Crispr activation screen with epigenetic regulatory candidates from mouse oocytes and zygotes was carried out in mouse ESCs in combination with single cell RNA-seq on a 10X Genomics platform. New candidates for zygotic genome activation were identified in this screen. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Is being taken up by others and expanded on by ourselves |
| URL | https://pubmed.ncbi.nlm.nih.gov/32634384/ |
| Title | PCR Bayes |
| Description | Novel algorithm to quantify expression and biological variability of steady state transcripts |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This is a novel tool which extends the capabilities of C elegans researchers to quantitate biological noise in single worms |
| Title | Parp1/2 knockout |
| Description | Established mouse knockout lines that lack Parp1 and Parp2. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | Possibility to study impact of these genes on imprinted gene regulation, the stability of chromatin organisation in general, and DNA damage responses. |
| Title | Pigl and Pigf mutant TSCs |
| Description | Generated and established trophoblast stem cell lines lacking either Pigl or Pigf. |
| Type Of Material | Cell line |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Mutant TSC lines being analysed at present for the impact of the gene mutation on self-renewal and differentiation capacities. |
| Title | Single cell multi-omics (scNMT-seq) |
| Description | Single cell triple-omics which records the transcriptome, methylome, and chromatin accessibility from the same single cell |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This method was applied to the first real biology question in 2019 on an investigation of mouse gastrulation (Argelaguet et al 2019 Nature). The joint first author Stephen Clark was awarded the researcher of the year award 2019 by the Cambridge Independent newspaper. |
| Title | Tet mutant TSCs |
| Description | Generated and established trophoblast stem cell lines lacking either Tet1, Tet2 or Tet1+Tet2. |
| Type Of Material | Cell line |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Enabling the assessment of the role of TET enzymes, and their product 5-hydroxymethylcytosine, on trophoblast stem cell maintenance, integrity and differentiation. |
| Title | Aging Cell 2018 |
| Description | We provide expression (RNA-seq) and epigenetic (ChIP-Seq and BS-Seq) data sets for young adult and aged mouse neural stem cells. The data are accessible at GEO under Accession Number GSE101610. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | We anticipate that other researchers will use our published data sets to identify candidate regulators of age-associated neurogenic decline. |
| Title | Cell Stem Cell 2017 |
| Description | We have deposited RNA-sequencing data related to our publication in Cell Stem Cell, 2017. The data have been uploaded to GEO under accession number GSE93241. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The data relate to the reprogramming of human pluripotent stem cells. We anticipate that these data will be used by other researchers. |
| Title | ChIP-seq profiles for Tet1 in TSCs (GSE109545) |
| Description | Chromatin binding profiles of Tet1 protein in trophoblast stem cells (TSCs) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Data allow to determine the functional role of Tet1 in TSCs |
| Title | ChIP-seq profiles for numerous transcription factors in TSCs (E-MTAB-3565) |
| Description | Chromatin binding profiles for Esrrb, Tfap2c, Lsd1, Nr0b1 and others in TSCs |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | Datasets were deposited in publicly available databases. Results helped identify the transcriptional networks operational in trophoblast stem cells, the precursors of the placenta. These insights will be immensely useful for other researchers in the field. |
| Title | Elf5 and Esrrb protein interactomes in TSCs (PXD002183) |
| Description | IP->MS/MS datasets of interaction partners of the key transcription factors Esrrb and Elf5 in trophoblast stem cells (TSCs). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | Data deposited in publicly accessible databases. Results are instrumental to gain a detailed understanding of how TSCs operate, which will be important to move the field of reproductive biology and pregnancy (normal and pathological) forward. |
| URL | http://www.ebi.ac.uk/pride/archive/ |
| Title | Profiling of epigenetic reprogramming between ESCs, MEFs and TSCs |
| Description | DNA methylation profiles of various ESC->TSC reprogramming models, as well as MEF->TSC reprogramming. |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Datasets are deposited in publicly accessible databases. Findings show that an epigenetic memory is retained when reprogramming from ECSs, but less so when MEFs are used as starting material. |
| Title | Stem Cell methylomes |
| Description | DNA methylation (meDIP)-seq profiling of ESCs, TSCs, XEN cells and EpiSCs |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Data were deposited in publicly accessible databases. Data will be useful to many other researchers for meta-analyses. |
| Title | Transcriptome datasets of reproductive tissues in ageing females (GSE98901) |
| Description | RNA-seq datasets of trophoblast, endometrium and deciduae of mouse conceptuses developed in young versus aged females |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Significant changes imposed by maternal age on expression profiles of endoemtrial tissue and decidual development. Work shows the impact of the older female on reproductive success, unrelated to oocyte fitness. |
| Title | We submit every year hundreds to thousands of new database entries these are all linked to the publications associated with the grants |
| Description | please see above |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | please see above |
| Title | Webtool for integration of high-throughput datasets and their rapid analysis |
| Description | Generation of a webtool allowing rapid data analysis of high-througput sequencing datasets. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Webtool allows to upload and integrate multiple datasets of different nature (such as ChIP-seq, RNA-seq, DNA methyaltion profiles) and allows to perform rapid multivariate analyses on them to find co-occpuancy, mutual exclusion etc |
| Title | eLife 2017 |
| Description | High-through sequencing data related to our 2017 published in eLife. Data deposited in GEO under accession number GSE86821 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | We provide the coordinates for promoter-enhancer interactions in human pluripotent cells and differentiated cells. The data will be re-used by other researchers. Too early for measured impacts. |
| Description | Active Motif DNA modification antibody |
| Organisation | Active Motif |
| Country | United States |
| Sector | Private |
| PI Contribution | Commercialisation of DNA modification antibodies we have made |
| Collaborator Contribution | Commercialisation of DNA modification antibodies we have made |
| Impact | Commercially available antibodies |
| Start Year | 2016 |
| Description | Alex Meissner |
| Organisation | Harvard University |
| Department | Department of Stem Cell and Regenerative Biology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Epigenomics and single cell multi-omics sequencing |
| Collaborator Contribution | Crispr mouse mutants and protocols |
| Impact | Several datasets. |
| Start Year | 2019 |
| Description | Austin Smith |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Epigenomics and multi-omics sequencing |
| Collaborator Contribution | Human and mouse pluripotent stem cells |
| Impact | Several collaborative publications. |
| Start Year | 2013 |
| Description | CEGX |
| Organisation | Cambridge Epigenetix |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Data generated by CASE PhD student as preliminary/pilot data for target validation of epigenetic changes in disease. |
| Collaborator Contribution | Industrial CASE PhD studentship partner Cambridge Epigenetix (CEGX) provided help and advice in novel, proprietary technique and enabled student to perform this new method of epigenetic target validation during the placement period. |
| Impact | PhD studentship in progress. Manuscript(s) will be generated from this work, possibly even targets for follow-on work and potential commercialisation as epigenetic biomarkers. |
| Start Year | 2016 |
| Description | Collaboration with Alvaro Rada-Iglesias |
| Organisation | University of Cantabria |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Single cell multi-omics |
| Collaborator Contribution | In vitro PGCLC model |
| Impact | First datasets have been obtained. A training visit has taken place. |
| Start Year | 2019 |
| Description | Collaboration with Fredrik Lanner |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Help and assistance with multi-omics single cell sequencing and computational analysis |
| Collaborator Contribution | Collection of human embryo cells |
| Impact | Paper is in preparation. Embryology, single cell genomics, computation. |
| Start Year | 2017 |
| Description | Collaboration with James Turner |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are providing help and training with scNMT-seq |
| Collaborator Contribution | Collected samples from marsupial embryos for sequencing |
| Impact | None yet |
| Start Year | 2018 |
| Description | Deciduoma |
| Organisation | National Institute of Environmental Health Sciences |
| Department | Reproductive and Developmental Biology Laboratory |
| Country | United States |
| Sector | Public |
| PI Contribution | Characterisation of reproductive defects in older females |
| Collaborator Contribution | Decidualisation model to assess the effect in the absence of an implanting embryo |
| Impact | Collaborative publication (PMID: 28874785) |
| Start Year | 2016 |
| Description | Greg Findlay - Biochemistry of DNMT1 and UHRF1 and demethylation |
| Organisation | University of Dundee |
| Department | National Centre for Protein Kinase Profiling |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have purified proteins and sent them to Greg Findlay's lab for proteomics and phosphoproteomics |
| Collaborator Contribution | They have identified several phosporylation sites of interest |
| Impact | Biochemistry, genetics, epigenetics, developmental biology |
| Start Year | 2018 |
| Description | Jenny Nichols mouse and human embryology |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Single cell multi-omics, mutants of epigenetic regulators. |
| Collaborator Contribution | Mouse and human embryos |
| Impact | Several collaborative publications and two joint grants. Multi-disciplinary between epigenetics, multi-omics, embryology, stem cell research. |
| Start Year | 2014 |
| Description | MRC EASIH |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | increased opportunities for deep sequencing using alternative platforms such as Roche 454 and ABI Solid |
| Collaborator Contribution | MRC East Anglia Sequencing and Informatics Hub established in 2009 |
| Impact | see above |
| Start Year | 2009 |
| Description | Meri Huch |
| Organisation | Max Planck Society |
| Department | Center for Systems Biology Dresden |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | Single cell multi-omics |
| Collaborator Contribution | Mouse model of liver regeneration |
| Impact | Several datasets. Multi-disciplinary between epigenetics, multi-omics, disease modelling. |
| Start Year | 2017 |
| Description | Neil Brockdorff - X chromosome inactivation |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We helped with DNA methylome sequencing and analysis |
| Collaborator Contribution | Contributed relevant samples for sequencing |
| Impact | See publications. Biochemistry, cell biology, epigenomics, computational biology. |
| Start Year | 2016 |
| Description | Richard Gilbertson epigenetics of childhood cancer |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We carry out multi-omics sequencing |
| Collaborator Contribution | Model of childhood cancer in mice |
| Impact | Sequencing results. Collaboration is betten epigenetics and cancer biology. |
| Start Year | 2018 |
| Description | Role of Np95 in epigenetic reprogramming |
| Organisation | RIKEN |
| Country | Japan |
| Sector | Public |
| PI Contribution | We are analysing the effects of Np95 deletion in zygotes and early embryos |
| Collaborator Contribution | Contribution of unpublished conditional knockout in the key epigenetic regulator Np95 |
| Impact | The first results have been obtained and look quite interesting |
| Start Year | 2008 |
| Description | Shankar Balasubramanian - nucleosome positioning depending on DNA modifications |
| Organisation | University of Cambridge |
| Department | Cancer Research UK Cancer Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided embryonic stem cell and mouse embryo samples |
| Collaborator Contribution | Analysed nucleosome positioning in samples provided by our lab |
| Impact | See publications. Chemistry, biochemistry, developmental biology, epigenomics. |
| Start Year | 2016 |
| Description | Steffen Rulands |
| Organisation | Max Planck Society |
| Department | Max Planck Institute for the Physics of Complex Systems |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Single cell multi-omics datasets |
| Collaborator Contribution | Modelling approaches for single cell multi-omics datasets |
| Impact | One collaborative publication. Multi-disciplinary between biology and theoretical physics. |
| Start Year | 2015 |
| Description | TET interactome |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Establish Tet1 binding profile in TSCs |
| Collaborator Contribution | Analyse data in an integrated fashion together with 3D structural organisation data of DNA in TSCs |
| Impact | Manuscript in preparation |
| Start Year | 2017 |
| Description | Thorsten Boroviak - single cell multi-omics of primate development |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Carrying out single cell multi-omics on samples from non-human primates |
| Collaborator Contribution | Providing samples from non-human primates |
| Impact | See publications. Developmental biology, epigenomics, computational biology. |
| Start Year | 2017 |
| Description | Trophoblast Stem Cells |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generation of locus-specific DNA methylation profiles to confirm lineage identity of derived cells. |
| Collaborator Contribution | Establishment of an organoid system that promotes the maintenance of human trophoblast stem/progenitor cells. |
| Impact | Publication in process. This collaboration is multi-disciplinary between pathologists, physiologists and us as epigeneticists, it also involved bio-engineering helping in the design of microfluidics devices. |
| Start Year | 2017 |
| Description | XIMBIO DNA modification antibodies |
| Organisation | Cancer Research Technology (CRT) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Commercialisation of DNA modification antibodies we have made |
| Collaborator Contribution | Commercialisation of DNA modification antibodies we have made |
| Impact | DNA modification antibodies |
| Start Year | 2016 |
| Description | single cell TSCs |
| Organisation | University of Cambridge |
| Department | Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Prof Steve Charnock Jones to form core of Centre of Trophoblast Research single cell transcriptomics profiles of mouse (and human) trophoblast stem cells under various conditions, as well as of placentas. Provided cells and tissues and culture media components to collaborator. |
| Collaborator Contribution | Set up Drop-seq and optimising technique for nuclear RNA sequencing, required for syncytia. Performed sc-RNA-seq. |
| Impact | Manuscript in preparation. |
| Start Year | 2017 |
| Description | uNK cells |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Characterisaiton of reproductive problems in older females. |
| Collaborator Contribution | Analysis of immune repertoire of implantation sites depending on maternal age. |
| Impact | Collaborative publication (PMID: 28874785). |
| Start Year | 2016 |
| Title | CASE studentship agreement |
| Description | A studentship in collaboration with industry |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | The student has successfully passed their viva |
| Title | Collaboration agreement |
| Description | This collaboration agreement covers work to be carried out under the Wellcome Human Developmental Biology Initiative |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2019 |
| Licensed | No |
| Impact | None yet |
| Title | Exclusive license agreement |
| Description | Antibodies against DNA modifications |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | No |
| Impact | Income to the Institute |
| Title | Methylome of human blastocysts |
| Description | Collaboration agreement with Karolinska Institute |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | Several datasets have been obtained |
| Title | Non-exclusive license agreement |
| Description | Antibodies against DNA modifications |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Commercial In Confidence |
| Impact | Income to the Institute |
| Title | Non-exclusive license agreement |
| Description | Antibodies against DNA modifications |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2011 |
| Licensed | Commercial In Confidence |
| Impact | Income to the Institute |
| Title | UKRMP2 pluripotent stem cell and engineered cell hub |
| Description | Collaboration agreement with PSEC on human pluripotent stem cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | Several datasets have been obtained |
| Description | 15th International Curie Course on Epigenetics - Paris |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2019 Keystone Symposia on Single Cell Biology - Colorado |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | 3rd Revolutionizing Next-Generation Sequencing Conference - Belgium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | BBSRC Institutes Collaborative Workshop on Epigenetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | BBSRC Institutes Collaborative Workshop on Epigenetics Babraham Institute, Cambridge, UK (November 2018) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Babraham Schools day 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Experiments on epigenetics for local 6th form schools |
| Year(s) Of Engagement Activity | 2018 |
| Description | Biology of Aging Gordon Research Conference - Maine, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Babraham Institute exhibit on the Epigenetic Ageing Clock presented at the Cambridge Science Festival, involving activities and question/answer interactions with members of the public |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival: Molecular Explorers, Cambridge (UK) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Exhibit at Cambridge Science Festival, engaging with visitors at stall explaining the science and advances made in the area, answering questions and discussing outstanding research goals |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cardiff Sixth Form Careers Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Online careers talk given to sixth form students. Covered careers in bioscience and personal career route as well as epigenetics broadly and specific research interests |
| Year(s) Of Engagement Activity | 2021 |
| Description | Cold Spring Harbor Laboratory meeting: Stem Cell Biology, New York (USA) (VPG, CS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Participation in confenrence, poster presentation by both post-doctoral reserachers involved in this activity (VPG and CS) and engagement in discussions and broadening of scientific horizon |
| Year(s) Of Engagement Activity | 2017 |
| Description | Computational Modeling in Biology Network |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I created COMBINE to coordinate the development of standards in computational systems biology. The initiative includes several workshops a year (discussion of future standards, implementation of current standards, and end-user training), diffusion lists, social media dissemination. |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017,2018 |
| URL | http://co.mbine.org |
| Description | Distinguished Lecture Speaker - University of Pennsylvania |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | EMBL Conference: Chromatin and Epigenetics - Heidelberg |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | EMBL Mammalian Genetics and Genomics Conference (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at AMBL Conference Mammalian genetic and Genomic, Heidelberg, Germany |
| Year(s) Of Engagement Activity | 2017 |
| Description | EMBL-EBI Industry Programme Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Epigenetics for Aging and Disease EMBL-EBI Industry Programme Workshop European Bioinformatics Institute, Cambridge, UK (November 2018) |
| Year(s) Of Engagement Activity | 2018 |
| Description | EU-Life meeting Principles of Homeostasis, Berlin (Germany) (VPG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Participation and poster presentation at EU LIfe meeting "Principles of Homeostasis" held in Berlin, Germany (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Epigenetics Escape Room Camb Fest Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Online escape room style engagement resource. Developed by researchers with puzzles linking to real life research. Event was run as part of Cambridge Festival with public audiences taking part and learning more about the Insitute and our epigenetics research |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://escape.babraham.ac.uk/ |
| Description | Epigenetics Escape Room Cambridge Science Festival event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Online escape room style engagement resource. Developed by researchers with puzzles linking to real life research. Event was run as part of Cambridge Science Festival with public audiences taking part and learning more about the Institute and our epigenetics research |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://escape.babraham.ac.uk/ |
| Description | Epigenetics Escape Room Swavesay Village College |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Online escape room style engagement resource. Developed by researchers with puzzles linking to real life research. Event was run as a facilitated session with students taking part in activites whilst also including careers and mini research talks to allow two-way engagement with students |
| Year(s) Of Engagement Activity | 2021 |
| Description | Form the Future School Careers Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 180 sixth form aged students attended this event (hosted at St Bedes School, Cambridge) where staff discussed and answered questions about what a bioscience career is like as well as discussing research interests. Teachers reported that students had increased their knowledge of such careers and especially highlighted the breadth of different roles the event highlighted to them. |
| Year(s) Of Engagement Activity | 2021 |
| Description | GENIE network of C elegans researchers |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Joining this pan european network has allowed us to attend conferences, network with other C elegans labs across Europe and obtaining funding to organise a workshop on C elegans metabolic reconstruction. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
| Description | GENiE workshop "Extending the consensus representation of C. elegans metabolism" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | https://www.helmholtz-muenchen.de/genie-workshop-2017/program/index.html |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.helmholtz-muenchen.de/genie-workshop-2017/program/index.html |
| Description | General public workshop "Cambridge Climate and sustainability festival" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker at "Cambridge Climate and sustainability festival" at St John's college February 16th, 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics Society and BSDB Spring Meeting, Warwick, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at annual spring meeting of the Genetics Society and British Society for Developmental Biology (BSDB) in Warwick, UK (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Genetics Society annual autumn meeting - poster presentation RS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of a poster with the newest data on this work. Meeting held in London, UK (2017). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Genetics Society annual autumn meeting - poster presentation RS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation by postdoc RS at above conference, interaction with other experts in the field, new ideas for research directions developed |
| Year(s) Of Engagement Activity | 2016 |
| Description | Genome editing workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Workshop about Crispr genome editing at the Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2019 |
| Description | How big data is changing science |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Tom Chivers on "How big data is changing science" (https://mosaicscience.com/story/how-big-data-changing-science-algorithms-research-genomics/) |
| Year(s) Of Engagement Activity | 2018 |
| Description | I'm a scientist |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Took part in online discussion forum events where students ask questions around careers in bioscience and research interests. Discussed career route, academic research landscape and epigenetic research. Was voted by students to win the 'zone'. |
| Year(s) Of Engagement Activity | 2021 |
| Description | IFPA Meeting, Manchester, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at IFPA Meeting held in Manchester, UK (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | IMP Research Institute of Molecular Pathology - Vienna |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | ISSHP Meeting, Berlin, Germany (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at ISSHP Meeting held in Berlin, Germany (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | InsideSTEM Initiative |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Two teachers visited the Babraham Institute as part of the InsideSTEM initiative in October 2018; I hosted the teachers for one day. I explained the ongoing research efforts in my lab, and we discussed possible ways to incorporate aspects of the research undertaken at the Babraham Institute into their curriculum. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at Lonza Biologics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited seminar and discussion at Lonza Biologics. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited seminar at Queen Mary University London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk and discussion at the Queen Mary University London. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited seminar at The Crick Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at The Crick Institute and a day of meeting other researchers. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker invitation - Grand Rapids, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at Stem Cells UK meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture to Stem Cells UK meeting. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keynote speaker, CTR Anniversary Meeting, Cambridge, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Keynote lecture at 10th Anniversary Meeting of the Centre for Trophoblast Research, University of Cambridge (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Life2019 Conference - Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lister fellowship |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | · Sanjush Dalmia (host Chris Todd) supported by Lister fellowship |
| Year(s) Of Engagement Activity | 2021 |
| Description | Lister fellowship |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Tom Hopkins (host Aled Parry) supported by Lister fellowship |
| Year(s) Of Engagement Activity | 2021 |
| Description | London International Youth Science Forum |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Around 40 international pupils visited the Babraham Institute as part of the programme during the London International Youth Science Forum (LIYSF), for which they had been selected. I gave a presentation on pluripotent stem cells and genome organisation, and a tour for the pupils around the institute. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Media comment on research related to ageing and rejuvenation |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Contribution of a comment on research reprogramming cells from an 114 year old individual in Newsweek article: Scientists Have Reset Cells From a Supercentenarian, Giving Clues to Their Extreme Longevity, |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.newsweek.com/supercentenarian-cells-reset-aging-longevity-1494497 |
| Description | Meeting organiser, Reproduction and Development, Cambridge 2018 (MH) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Co-organisation of meeting, Reproduction and Development, held in Cambridge, UK (2018). |
| Year(s) Of Engagement Activity | 2018 |
| Description | NIB conference poster presentation (RS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Participation including poster presentation at National Institutes of Bioscience (NIB) conference 2015. Engagement with other BBSRC institutes' scientists and research focus. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Nine invited presentations at international meetings, including EMBO, FASEB, Keystone, American Association for Cancer Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Conference presentations about our research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Online article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Coverage of a press release: The Spatial Mouse Atlas. Research by the Reik lab (and in collaboration with others including the EMBL-EBI) combined gene expression maps with single-cell genomics data to create an atlas of the cell types found in mouse embryos. The press release was picked up by several outlets including phys.org, RNA-Seq Blog and News2read among others. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://phys.org/news/2021-09-spatial-mouse-atlas-insights-cell.html |
| Description | Online article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Blog post where six of our current PhD students shared some tips and advice for new PhD students starting |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.babraham.ac.uk/blog/advice-new-PhD-students |
| Description | Organisation of C.elegans Cambridge local area meetings |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | An audience of about 10-15 science labs from around the Cambridge area attend these events, including many PhD students and postdocs. The aim of these meetings is dissemination of techniques and science as well as networking. |
| Year(s) Of Engagement Activity | 2015,2017,2018 |
| Description | Panel discussion for NCCPE Engage Conference |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was a panel member for the session: "Public dialogues: A valuable tool for Higher Education Institutes?" at the NCCPE Engage Conference 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://babraham.ac.uk/blog/2021/01/public-dialogue-spur-genome-editing-engagement |
| Description | Partcipation in The Future of Ageing |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A representative of the Casanueva lab attended a debate on the future of gein at London School of Economics geared towards general public. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Podcast with Dr Kat Arney on the impact of placentation and maternal age on reproductive outcome |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast as descibed above |
| Year(s) Of Engagement Activity | 2017 |
| Description | Postgraduate course Epigenetics in Reproductive Biology, University of Murcia, Spain (VPG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk and workshop participation as part of postgraduate course on reproductive epigenetics |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Presentation to the EMBL-EBI Industry program |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation to the EMBL-EBI Industry program, representing pharma and agri-food industry, on the use of genome scale metabolic models for personalised medicine. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Protein Challenge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Students are given the opportiunity to become immersed in a hands-on research project where they carry out practical experiments involving protein assaying. They then produce a scientific poster based on their results and present these. The porgramme takes place over a number of sessions with support for the students to develop their wider research skills and understanding of research ethics. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Radio interview DeutschlandFunk |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio Interview for DeutschlandFunk on the impact of maternal age on pregnancy success, irrespective of the increased risk of defects in the egg |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.deutschlandfunk.de/alter-des-uterus-entscheidend-junges-glueck-in-jungen.676.de.html?dram... |
| Description | Research Access Programme Student Placement |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Higher education student carried out 5 week online summer placement learning a variety of techniques and data analysis methods. They reported an increase in knowledge, skills, and a broadening of their understanding of careers in science as well as how academic research functions |
| Year(s) Of Engagement Activity | 2021 |
| Description | Research Access Programme Student Placement (Maria Rostovskaya) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Higher education student carried out 5 week online summer placement learning a variety of techniques and data analysis methods. They reported an increase in knowledge, skills, and a broadening of their understanding of careers in science as well as how academic research functions |
| Year(s) Of Engagement Activity | 2021 |
| Description | Royal Society Partnering Award - CS + LW, NM, SC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Successful application for Royal Society Partnering Award. Poster 6 selected 6th form students over the course of 1 week and conducted in-depth research project. Data analysis followed at the pupils' school directly. |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Royal Society Summer Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Babraham Institute exhibit on the Epigenetic Ageing Clock as invited entry presented at the Royal Society Summer Exhibition, involving activities and question/answer interactions with members of the public, fellows of the Royal Society, policymakers |
| Year(s) Of Engagement Activity | 2018 |
| Description | Savile Club epigenetics talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation about epigenetics at the London Savile Club |
| Year(s) Of Engagement Activity | 2018 |
| Description | Schools Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Project design, scientific background induction and practical supervision for 6th form students as well as teachers during Annual Schools Day. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| Description | Schools Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Groups of 5-6 6th-form students take part in a one-day visit to 2 research groups at the Babraham Institute and conduct two small research experiments during that day. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Schools Day 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Around 200 pupils attended for our annual School's Day, of which 10 participated in the activities organised by my group. We talked with pupils about genes, gene mutations, regulatory elements, cellular differentiation and lineage specification, stem cells, and three-dimensional genome organisation. For the practical part, the students performed a fluorescent in situ hybridisation (FISH) experiment to determine the nuclear localisation of an enhancer relative to its target gene in the three-dimensional space of the nucleus. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Schools Day 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Around 250 pupils attended for our annual School's Day, of which 9 participated in the activities organised by my group. We talked with pupils about genes, gene mutations, regulatory elements, cellular differentiation and lineage specification, stem cells, and three-dimensional genome organisation. For the practical part, the students performed a fluorescent in situ hybridisation (FISH) experiment to determine the nuclear localisation of an enhancer relative to its target gene in the three-dimensional space of the nucleus. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Scientist Stories |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Recorded interview style discussion about research interests and career route. This recording was circulated around regional school teachers for use in classes and more widely through Institute social media channels. Teachers reported students being much more aware of the range of career routes when considering a role in science. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Sophianum School collaboration - Technasium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | The Babraham Institute is continuing to coordinate activities supporting its commitment as a signatory of the Concordat on Openness on Animal Research. Institute staff, including animal unit managers, have been working closely with a school in the Netherlands to prepare and launch the Institute's contribution to the national 'Technasium' education programme, which aims to draw together students and industry. Two projects, developed in collaboration with the Institute's Public Engagement team and teachers from the Sophianum School in Gulpen, will challenge students to research and design systems to improve the efficiency and safety of animal care systems. A third project will require the students to research how legislation regulating the use of animals in science, as well as public opinion, can vary throughout Europe and the world. A two-day visit on 19th & 20th May will kick-start a 10-week programme for the 15-year old students, who will work in teams and compete to design the best solutions to the challenges. The Institute's animal technicians will monitor student progress by commenting on YouTube videos posted fortnightly by the teams. Regular video calls into the animal unit and the Institute's laboratories will allow live discussion between the students, the animal technicians and the scientists who use animals as part of their research. The challenge projects will finish in July, with the winning Sophianum team coming to the Babraham Institute as part of their prize. The students will visit Institute animal facilities and will get a chance to see the award-winning camera system which displays live feeds from the facility - allowing groups to appreciate first-hand both the animal care environment and the nature of working within an animal research unit. This pilot project will also involve sixth-form students at the school who will learn about the Institute's research and take part in workshops to discuss the ethics of the use of animals in science. The Institute has been running ethics workshops for secondary and sixth form students since 2005, with contributions from Understanding Animal Research, the European Animal Research Association and the Institute of Animal Technology. The success of the Technasium project will be evaluated by both the Institute and Sophianum School, with a view to developing future challenges. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Sophianum poster workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A scientific poster workshop for the Sophianum school in the Netherlands |
| Year(s) Of Engagement Activity | 2019 |
| Description | Sophianum sixth form project judging |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Sixth form students wrote scientific projects which were then judged |
| Year(s) Of Engagement Activity | 2019 |
| Description | Sophianum visit to BI |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | School visit by dutch school classes |
| Year(s) Of Engagement Activity | 2019 |
| Description | St Catharines Society Visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A presentation and discussion at the St Catherine's society |
| Year(s) Of Engagement Activity | 2019 |
| Description | Summer student |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Sebastian Ljung (host Jasmin Stowers) (summer student) |
| Year(s) Of Engagement Activity | 2021 |
| Description | SysMod 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I organised the 2nd meeting of the ISCB Community of Special Interest SysMod. Up to 270 people attended depending on the talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk at Cambourne Library |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 15 general audience attended an Epigenetics presentation and discussion |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Ageing Cell Conference, Cambridge, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk at The Ageing Cell Conference held in Cambridge, UK (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Twilight teacher training event, Bioscience lite-CRISPR-Cas9 genome editing- technology, applications and implication, Cambridge (UK) (VPG) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Talk and Q&A session with high school teachers to update and inform them on state-of-the-art genome editing tools |
| Year(s) Of Engagement Activity | 2017 |
| Description | UKRI launch |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | UKRI launch event 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Undergraduate Work Placement Programme 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Undergraduate students completed a 4 week online work experience placement in our laboratories with a programme of talks about life as a researcher and careers in science. |
| Year(s) Of Engagement Activity | 2020 |
| Description | WT/EBI course in silico systems biology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I organised this one-week course, and gave presentations entitled: "What is Systems Biology? Where does it come from?", "The many faces of modelling in biology", "Modelling in systems biology, a few challenges", "From art to engineering: two decades of standards and tools towards digital organisms", "Modelling chemical kinetics" plus a tutorial on stochastic simulations of biological systems. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Weert College ethics workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This was a scientific ethics workshop for a school in the Netherlands |
| Year(s) Of Engagement Activity | 2019 |
| Description | Weert College presentation judging |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Students were making scientific presentations which were then judged |
| Year(s) Of Engagement Activity | 2019 |
| Description | Wellcome Genome Campus Cell Fate Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | This was an invitation only workshop organised by us on the Hinxton campus which brought together some of the international leaders working on cell fate biology and pathology. A meeting report was produced subsequently. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Wellcome Trust Workshop on NEURONAL MATURATION: London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | Whittlewomen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation to local women's group |
| Year(s) Of Engagement Activity | 2019 |
| Description | Women's Institute visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Visit by members of the Women's Institute for a discussion and workshop on Epigenetics |
| Year(s) Of Engagement Activity | 2019 |
| Description | eLife Community Webinar - Refreshing approaches to researcher evaluation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I animated a webinar discussing various ways to bypass the traditional publication-based evaluation of researchers. |
| Year(s) Of Engagement Activity | 2017 |