Transgenerational epigenetic inheritance: mechanisms and consequences for metabolism and ageing
Lead Research Organisation:
Babraham Institute
Department Name: UNLISTED
Abstract
Epigenetic changes that occur during the lifetime of an individual are generally not inherited by the next generation, as this could subvert epigenetic reprogramming events needed to reinstate totipotency. Yet, some genomic elements remain incompletely reprogrammed, and may thus represent a key genomic vehicle for transgenerational epigenetic inheritance47. Transgenerational inheritance requires that the germline remembers exposure to environmental changes and allows for these to be inherited to the next generation(s). Nutritional stress can mediate transgenerational memory through histone marks and small RNA pathways in invertebrates and DNA methylation changes in mice48,49. As observed in many studies, the inheritance mediated by epigenetic modifications reverts back to wild-type after one or a few generations. However, some epigenetic changes can lead to more permanent genome rearrangements, when coupled to genomic instability. For example, nutritional stress can lead to instability of high copy number ribosomal DNA (rDNA), resulting in copy number variation (CNV) at rDNA loci. There are many key aspects that remain unresolved in the field and this Objective tackles two essential questions: firstly, what are the mechanisms by which epigenetic reprogramming normally returns cells to a naïve and totipotent stage and could these mechanisms thereby mediate transgenerational inheritance upon experimental manipulation. Secondly, can, and if so how could, stressors such as age and nutrition contribute to inheritance by modifying CNV through gametes with consequences for metabolism and ageing in subsequent generations.
Organisations
- Babraham Institute, United Kingdom (Lead Research Organisation)
- Queen Mary, University of London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- National Institute of Environmental Health Sciences (Collaboration)
- Swiss Federal Institute of Technology (ETH), Zurich (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
- Cambridge Epigenetix (Collaboration)
Publications
Brighton PJ
(2017)
Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium.
in eLife
Hull RM
(2017)
Environmental change drives accelerated adaptation through stimulated copy number variation.
in PLoS biology
Sarker G
(2018)
Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.
in Translational psychiatry
Sun W
(2018)
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
in Nature medicine
Woods L
(2017)
Decidualisation and placentation defects are a major cause of age-related reproductive decline.
in Nature communications
| Description | Epigenetic changes that accumulate during the lifetime of an individual and that occur in response to the environment are usually erased by epigenetic reprogramming to reinstate pluripotency. However, some genomic elements remain incompletely reprogrammed and can be heritable for several generations. We have studied two examples of epigenetic inheritance. First, we observe that a high fat diet during gestation can result in the inheritance of addictive behaviors, obesity and insulin resistance in the progeny for up to 3 generations (PMID 30315171). Second, cold exposure of males before mating results in improved systemic metabolism and protection from diet induced obesity in male-offspring, which may be transmitted by an altered methylome in cold exposed sperm (PMID 29988127). As observed in many studies, the inheritance mediated by epigenetic modifications reverts back to wild-type after one or a few generations. However, some epigenetic changes can lead to more permanent genome rearrangements, when coupled to genomic instability. We have done this using yeast cells and learned that copy number of environmentally responsive genes can be induced in response to the environment (PMID: 28654659). We have determined rDNA copy number changes in ageing yeast (PMID:30274593) but observe no change in heritable chromosomal rDNA copy number but can be heritable as extrachromosomal DNA (manuscript in preparation). |
| Exploitation Route | (1) We will work on repository sites which contains experimental details of the protocols that are in use for this proposal and those which represent high novelty, in order to share expertise with the scientific community (2) disseminate the results of our work and exchanges ideas with colleagues at national and international conferences. (3) We are seeking to identify partners to work with to exploit the outcomes of our research. This will be coordinated through the BI KE team and Babraham's wholly-owned trading arm, Babraham Commercialization Services (BCS), which promotes the commercialisation of results coming from the BI through filing and licensing patents and facilitating knowledge exchange with companies. (4) We are engaged in many events related to extending epigentic knowledge to the public (5) This awarded grant has made possible the training of postdocs and PhD Students as well as led to multiple national collaborations. |
| Sectors | Communities and Social Services/Policy,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| URL | http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001333 |
| Description | The Epigenetics ISP has been involved in several engagement activities with secondary degree students. For example, the Casanueva group obtained a Royal Society Partnership Grant in 2017, to introduce Colchester Highschool students to the use of model organisms to study ageing. Another example is that the Epigenetics ISP supported the Sophianum School in the Netherlands during 2017 and 2018. The Institute set challenge projects relating to the Institute's animal care facilities and Epigenetics to teams of secondary and sixth-form students as part of the national Dutch Technasium scheme. The collaboration won an Openness Award from Understanding Animal Research in December 2017. |
| First Year Of Impact | 2017 |
| Impact Types | Cultural,Societal |
| Description | Chair of SAB Centre for Trophoblast Research University of Cambridge |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Has changed the perception of placenta and trophoblast in reproduction |
| Description | Flagship |
| Amount | € 1,000,000 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2019 |
| End | 03/2020 |
| Description | Investigator Award |
| Amount | £2,600,000 (GBP) |
| Funding ID | 210754/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2023 |
| Title | C elegans Metabolic Reconstruction Model |
| Description | Merged and re-annotated C elegans Metabolic Reconstruction Model |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This is a great improvement to the C elegans research community |
| Title | PCR Bayes |
| Description | Novel algorithm to quantify expression and biological variability of steady state transcripts |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This is a novel tool which extends the capabilities of C elegans researchers to quantitate biological noise in single worms |
| Title | Transcriptome datasets of reproductive tissues in ageing females (GSE98901) |
| Description | RNA-seq datasets of trophoblast, endometrium and deciduae of mouse conceptuses developed in young versus aged females |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Significant changes imposed by maternal age on expression profiles of endoemtrial tissue and decidual development. Work shows the impact of the older female on reproductive success, unrelated to oocyte fitness. |
| Title | copper response in yeast |
| Description | Response of yeast to copper treatment by RNAseq and replication fork stalling |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | data re-use |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE86283 |
| Description | CEGX |
| Organisation | Cambridge Epigenetix |
| PI Contribution | Data generated by CASE PhD student as preliminary/pilot data for target validation of epigenetic changes in disease. |
| Collaborator Contribution | Industrial CASE PhD studentship partner Cambridge Epigenetix (CEGX) provided help and advice in novel, proprietary technique and enabled student to perform this new method of epigenetic target validation during the placement period. |
| Impact | PhD studentship in progress. Manuscript(s) will be generated from this work, possibly even targets for follow-on work and potential commercialisation as epigenetic biomarkers. |
| Start Year | 2016 |
| Description | Christian Wolfrum - transgenerational epigenetic inheritance |
| Organisation | ETH Zurich |
| Department | Institute of Food, Nutrition and Health |
| Country | Switzerland |
| Sector | Public |
| PI Contribution | Carried out transcriptome and methylome analysis of transgenerational epigenetic models |
| Collaborator Contribution | Provided transgenerational epigenetic mouse models of high fat diet and cold shock |
| Impact | Behavioural studies, nutrition, epigenetics, epigenomics, transcription |
| Start Year | 2016 |
| Description | Deciduoma |
| Organisation | National Institute of Environmental Health Sciences |
| Department | Reproductive and Developmental Biology Laboratory |
| Country | United States |
| Sector | Public |
| PI Contribution | Characterisation of reproductive defects in older females |
| Collaborator Contribution | Decidualisation model to assess the effect in the absence of an implanting embryo |
| Impact | Collaborative publication (PMID: 28874785) |
| Start Year | 2016 |
| Description | Development of computational methods for the quantification of biological variability |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of an algorithm based on Bayesian statistics that quantifies variability in steady state levels of mRNA from nanofluidics-based PCR. |
| Collaborator Contribution | Development of an algorithm based on Bayesian statistics that quantifies variability in steady state levels of mRNA from nanofluidics-based PCR. |
| Impact | It is a multi-disciplinary collaboration involving high end PCR technology and statistical modelling. |
| Start Year | 2015 |
| Description | Rakyan for mouse rDNA |
| Organisation | Queen Mary University of London |
| Department | Blizard Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of mouse rDNA CNV assay |
| Collaborator Contribution | Mouse models and project lead |
| Impact | None yet... |
| Start Year | 2016 |
| Description | Uterine pathologies and maternal age |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Reproductive Health |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Molecular assessment of changes occurring in older females |
| Collaborator Contribution | Pathological characterisation and assessment of uterine pathologies that become more frequent with age |
| Impact | Collaboration established. Application for future funding in progress. |
| Start Year | 2017 |
| Description | single cell TSCs |
| Organisation | University of Cambridge |
| Department | Department of Obstetrics & Gynaecology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Prof Steve Charnock Jones to form core of Centre of Trophoblast Research single cell transcriptomics profiles of mouse (and human) trophoblast stem cells under various conditions, as well as of placentas. Provided cells and tissues and culture media components to collaborator. |
| Collaborator Contribution | Set up Drop-seq and optimising technique for nuclear RNA sequencing, required for syncytia. Performed sc-RNA-seq. |
| Impact | Manuscript in preparation. |
| Start Year | 2017 |
| Description | Article on JH lab research on WIRED website and in Quanta magazine |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on JH lab research following in-depth interview |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.wired.com/story/bacteria-may-rig-their-dna-to-speed-up-evolution/ |
| Description | Babraham Schools day 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Experiments on epigenetics for local 6th form schools |
| Year(s) Of Engagement Activity | 2018 |
| Description | British Yeast Group meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to scientists in this and other areas focused on yeast research |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2017-british-yeast... |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Babraham Institute exhibit on the Epigenetic Ageing Clock presented at the Cambridge Science Festival, involving activities and question/answer interactions with members of the public |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cold Spring Harbor Laboratory meeting: Stem Cell Biology, New York (USA) (VPG, CS) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Participation in confenrence, poster presentation by both post-doctoral reserachers involved in this activity (VPG and CS) and engagement in discussions and broadening of scientific horizon |
| Year(s) Of Engagement Activity | 2017 |
| Description | EMBL Mammalian Genetics and Genomics Conference (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at AMBL Conference Mammalian genetic and Genomic, Heidelberg, Germany |
| Year(s) Of Engagement Activity | 2017 |
| Description | EU-Life meeting Principles of Homeostasis, Berlin (Germany) (VPG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Participation and poster presentation at EU LIfe meeting "Principles of Homeostasis" held in Berlin, Germany (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | GENIE network of C elegans researchers |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Joining this pan european network has allowed us to attend conferences, network with other C elegans labs across Europe and obtaining funding to organise a workshop on C elegans metabolic reconstruction. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
| Description | GENiE workshop "Extending the consensus representation of C. elegans metabolism" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | https://www.helmholtz-muenchen.de/genie-workshop-2017/program/index.html |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.helmholtz-muenchen.de/genie-workshop-2017/program/index.html |
| Description | Genetics Society and BSDB Spring Meeting, Warwick, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at annual spring meeting of the Genetics Society and British Society for Developmental Biology (BSDB) in Warwick, UK (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Genetics Society annual autumn meeting - poster presentation RS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of a poster with the newest data on this work. Meeting held in London, UK (2017). |
| Year(s) Of Engagement Activity | 2017 |
| Description | IFPA Meeting, Manchester, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at IFPA Meeting held in Manchester, UK (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | ISSHP Meeting, Berlin, Germany (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at ISSHP Meeting held in Berlin, Germany (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Keynote speaker, CTR Anniversary Meeting, Cambridge, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Keynote lecture at 10th Anniversary Meeting of the Centre for Trophoblast Research, University of Cambridge (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Meeting organiser, Reproduction and Development, Cambridge 2018 (MH) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Co-organisation of meeting, Reproduction and Development, held in Cambridge, UK (2018). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Organisation of C.elegans Cambridge local area meetings |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | An audience of about 10-15 science labs from around the Cambridge area attend these events, including many PhD students and postdocs. The aim of these meetings is dissemination of techniques and science as well as networking. |
| Year(s) Of Engagement Activity | 2015,2017,2018 |
| Description | Partcipation in The Future of Ageing |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A representative of the Casanueva lab attended a debate on the future of gein at London School of Economics geared towards general public. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Podcast with Dr Kat Arney on the impact of placentation and maternal age on reproductive outcome |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast as descibed above |
| Year(s) Of Engagement Activity | 2017 |
| Description | Postgraduate course Epigenetics in Reproductive Biology, University of Murcia, Spain (VPG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk and workshop participation as part of postgraduate course on reproductive epigenetics |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Radio interview DeutschlandFunk |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio Interview for DeutschlandFunk on the impact of maternal age on pregnancy success, irrespective of the increased risk of defects in the egg |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.deutschlandfunk.de/alter-des-uterus-entscheidend-junges-glueck-in-jungen.676.de.html?dram... |
| Description | Royal Society Summer Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Babraham Institute exhibit on the Epigenetic Ageing Clock as invited entry presented at the Royal Society Summer Exhibition, involving activities and question/answer interactions with members of the public, fellows of the Royal Society, policymakers |
| Year(s) Of Engagement Activity | 2018 |
| Description | Savile Club epigenetics talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation about epigenetics at the London Savile Club |
| Year(s) Of Engagement Activity | 2018 |
| Description | Sophianum School collaboration - Technasium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | The Babraham Institute is continuing to coordinate activities supporting its commitment as a signatory of the Concordat on Openness on Animal Research. Institute staff, including animal unit managers, have been working closely with a school in the Netherlands to prepare and launch the Institute's contribution to the national 'Technasium' education programme, which aims to draw together students and industry. Two projects, developed in collaboration with the Institute's Public Engagement team and teachers from the Sophianum School in Gulpen, will challenge students to research and design systems to improve the efficiency and safety of animal care systems. A third project will require the students to research how legislation regulating the use of animals in science, as well as public opinion, can vary throughout Europe and the world. A two-day visit on 19th & 20th May will kick-start a 10-week programme for the 15-year old students, who will work in teams and compete to design the best solutions to the challenges. The Institute's animal technicians will monitor student progress by commenting on YouTube videos posted fortnightly by the teams. Regular video calls into the animal unit and the Institute's laboratories will allow live discussion between the students, the animal technicians and the scientists who use animals as part of their research. The challenge projects will finish in July, with the winning Sophianum team coming to the Babraham Institute as part of their prize. The students will visit Institute animal facilities and will get a chance to see the award-winning camera system which displays live feeds from the facility - allowing groups to appreciate first-hand both the animal care environment and the nature of working within an animal research unit. This pilot project will also involve sixth-form students at the school who will learn about the Institute's research and take part in workshops to discuss the ethics of the use of animals in science. The Institute has been running ethics workshops for secondary and sixth form students since 2005, with contributions from Understanding Animal Research, the European Animal Research Association and the Institute of Animal Technology. The success of the Technasium project will be evaluated by both the Institute and Sophianum School, with a view to developing future challenges. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Talk at British Yeast Group by Lab member Ryan Hull |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation at the British Yeast Group meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at Cambourne Library |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 15 general audience attended an Epigenetics presentation and discussion |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at DNA Replication as a Source of DNA Damage Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to other members of research community. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.fusion-conferences.com/conference67.php |
| Description | Talk at EMBO Evolution and Ecology meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk and poster presentation at EMBO meeting |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.embl.de/training/events/2018/EAE18-01/ |
| Description | Talk at EpiChrom 2019 by lab member Ryan Hull |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at EpiChrom 2019 meeting |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.scilifelab.se/epichrom-2019/ |
| Description | The Ageing Cell Conference, Cambridge, UK (MH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk at The Ageing Cell Conference held in Cambridge, UK (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | UKRI launch |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | UKRI launch event 2018 |
| Year(s) Of Engagement Activity | 2018 |