Transgenerational epigenetic inheritance: mechanisms and consequences for metabolism and ageing

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

Epigenetic changes that occur during the lifetime of an individual are generally not inherited by the next generation, as this could subvert epigenetic reprogramming events needed to reinstate totipotency. Yet, some genomic elements remain incompletely reprogrammed, and may thus represent a key genomic vehicle for transgenerational epigenetic inheritance47. Transgenerational inheritance requires that the germline remembers exposure to environmental changes and allows for these to be inherited to the next generation(s). Nutritional stress can mediate transgenerational memory through histone marks and small RNA pathways in invertebrates and DNA methylation changes in mice48,49. As observed in many studies, the inheritance mediated by epigenetic modifications reverts back to wild-type after one or a few generations. However, some epigenetic changes can lead to more permanent genome rearrangements, when coupled to genomic instability. For example, nutritional stress can lead to instability of high copy number ribosomal DNA (rDNA), resulting in copy number variation (CNV) at rDNA loci. There are many key aspects that remain unresolved in the field and this Objective tackles two essential questions: firstly, what are the mechanisms by which epigenetic reprogramming normally returns cells to a naïve and totipotent stage and could these mechanisms thereby mediate transgenerational inheritance upon experimental manipulation. Secondly, can, and if so how could, stressors such as age and nutrition contribute to inheritance by modifying CNV through gametes with consequences for metabolism and ageing in subsequent generations.

Publications

10 25 50
 
Description Epigenetic changes that accumulate during the lifetime of an individual and that occur in response to the environment are usually erased by epigenetic reprogramming to reinstate pluripotency. However, some genomic elements remain incompletely reprogrammed and can be heritable for several generations. We have studied two examples of epigenetic inheritance. First, we observe that a high fat diet during gestation can result in the inheritance of addictive behaviours, obesity and insulin resistance in the progeny for up to 3 generations (PMID 30315171). Second, cold exposure of males before mating results in improved systemic metabolism and protection from diet induced obesity in male-offspring, which may be transmitted by an altered methylome in cold exposed sperm (PMID 29988127). As observed in many studies, the inheritance mediated by epigenetic modifications reverts back to wild-type after one or a few generations. However, some epigenetic changes can lead to more permanent genome rearrangements when coupled to genomic instability. We have learned that in yeast copy number variation of environmentally responsive genes can be induced in response to the environment, driven by conflicts between replication and transcription (PMIDs 28654659, 35018465). We have also characterised the accumulation of extrachromosomal circular DNA during ageing (PMID 32609810), which has the potential to provide an adaptive advantage to aged cells by increasing genetic heterogeneity (PMID 32296868), and can also be driven by the expression of environmentally responsive genes (PMID: 31794573). Although ageing in yeast has been widely associated with extrachromosomal DNA from the ribosomal DNA cluster, we have found that extrachromosomal DNA contributes to senescence in yeast but not the underlying progression of ageing (manuscript in preparation). Besides transgenerational inheritance or induced genomic rearrangements, there is a vastly under-appreciated maternal effect role played by the placenta. A large-scale phenotyping effort demonstrated of at least 60 embryonic lethal and sub-viable mouse knockout lines show placental phenotypes. These correlate strongly with brain, heart and vascular defects (PMID: 29539633). This work can be mined to identify novel molecular hubs that may be critical for placental development (PMID:30319550) and molecular studies that uncouple this relationship can be further studied using placental organoids in vitro (PMID:30487605).
Exploitation Route (1) We will work on repository sites which contains experimental details of the protocols that are in use for this proposal and those which represent high novelty, in order to share expertise with the scientific community (2) disseminate the results of our work and exchanges ideas with colleagues at national and international conferences. (3) We are seeking to identify partners to work with to exploit the outcomes of our research. This will be coordinated through the BI KE team and Babraham's wholly-owned trading arm, Babraham Commercialization Services (BCS), which promotes the commercialisation of results coming from the BI through filing and licensing patents and facilitating knowledge exchange with companies. (4) We are engaged in many events related to extending epigenetic knowledge to the public (5) This awarded grant has made possible the training of postdocs and PhD Students as well as led to multiple national collaborations.
Sectors Communities and Social Services/Policy,Education,Healthcare,Pharmaceuticals and Medical Biotechnology

URL http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001333
 
Description The Epigenetics ISP has been involved in several engagement activities with secondary degree students. For example, the Casanueva group obtained a Royal Society Partnership Grant in 2017, to introduce Colchester Highschool students to the use of model organisms to study ageing. Another example is that the Epigenetics ISP supported the Sophianum School in the Netherlands during 2017 and 2018. The Institute set challenge projects relating to the Institute's animal care facilities and Epigenetics to teams of secondary and sixth-form students as part of the national Dutch Technasium scheme. The collaboration won an Openness Award from Understanding Animal Research in December 2017. . In 2021, BI launched an exciting new "Epigenetics Escape Room" as a virtual event at the Cambridge Science Festival in 2021 to engage audiences in the principles of epigenetics research and consequences for lifelong health, and in 2019 engaged with more senior audiences in the Institute for Continuing learning.
First Year Of Impact 2017
Impact Types Cultural,Societal

 
Description Chair of SAB Centre for Trophoblast Research University of Cambridge
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Has changed the perception of placenta and trophoblast in reproduction
 
Description Flagship
Amount € 1,000,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 02/2019 
End 03/2020
 
Description Investigator Award
Amount £2,600,000 (GBP)
Funding ID 210754/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 09/2023
 
Title C elegans Metabolic Reconstruction Model 
Description Merged and re-annotated C elegans Metabolic Reconstruction Model 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact This is a great improvement to the C elegans research community 
 
Title PCR Bayes 
Description Novel algorithm to quantify expression and biological variability of steady state transcripts 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact This is a novel tool which extends the capabilities of C elegans researchers to quantitate biological noise in single worms 
 
Title Characterisation of mRNA expression and replication fork stalling in copper-treated yeast 
Description Here we analyse steady state mRNA levels and yH2A-marked replication fork stalling sites in S. cerevisiae Overall design Histone modification (yH2A, gammaH2A) and transcriptome (mRNA-Seq) from wildtype BY4741 cells grown in YPD and treated for 4 hours with 0 or 1mM CuSO4 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Hull RM, Cruz C, Jack CV, Houseley J. Environmental change drives accelerated adaptation through stimulated copy number variation. PLoS Biol 2017 Jun;15(6):e2001333. PMID: 28654659 
URL https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE86283
 
Title Transcription-induced formation of extrachromosomal DNA during yeast ageing 
Description Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation, and is implicated in the pathology of cancer and ageing. Here, we demonstrate that yeast aged under environmental copper accumulate high levels of eccDNA containing the copper resistance gene CUP1. Transcription of CUP1 causes CUP1 eccDNA accumulation, which occurs in the absence of phenotypic selection. We have developed a sensitive and quantitative eccDNA sequencing pipeline that reveals CUP1 eccDNA accumulation on copper exposure to be exquisitely site specific, with no other detectable changes across the eccDNA complement. eccDNA forms de novo from the CUP1 locus through processing of DNA double-strand breaks (DSBs) by Sae2 / Mre11 and Mus81, and genome-wide analyses show that other protein coding eccDNA species in aged yeast share a similar biogenesis pathway. Although abundant we find that CUP1 eccDNA does not replicate efficiently, and high copy numbers in aged cells arise through frequent formation events combined with asymmetric DNA segregation. The transcriptional stimulation of CUP1 eccDNA formation shows that age-linked genetic change varies with transcription pattern, resulting in gene copy number profiles tailored by environment. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact PLoS Biol. 2019 Dec 3;17(12):e3000471. doi: 10.1371/journal.pbio.3000471. eCollection 2019 Dec. Transcription-induced formation of extrachromosomal DNA during yeast ageing Ryan M Hull 1 , Michelle King 1 , Grazia Pizza 1 , Felix Krueger 2 , Xabier Vergara 1 , Jonathan Houseley 1 PMID: 31794573 
URL https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135542
 
Title Transcriptome datasets of reproductive tissues in ageing females (GSE98901) 
Description RNA-seq datasets of trophoblast, endometrium and deciduae of mouse conceptuses developed in young versus aged females 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Significant changes imposed by maternal age on expression profiles of endoemtrial tissue and decidual development. Work shows the impact of the older female on reproductive success, unrelated to oocyte fitness. 
 
Title We submit every year hundreds to thousands of new database entries these are all linked to the publications associated with the grants 
Description please see above 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact please see above 
 
Title copper response in yeast 
Description Response of yeast to copper treatment by RNAseq and replication fork stalling 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact data re-use 
URL https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE86283
 
Description Artios Pharma 
Organisation Artios Pharma Limited
Country United Kingdom 
Sector Private 
PI Contribution We have recruited a PhD student for a CASE award shared between JH lab and Artios Pharma.
Collaborator Contribution Supporting the student's research, providing reagents, supervision and advice, and a financial contribution to research costs and student stipend.
Impact None yet
Start Year 2019
 
Description Astra Zeneca for selumetinib paper 
Organisation AstraZeneca
Department Research and Development AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution We performed the research in this project.
Collaborator Contribution This was started in collaboration with Astra Zeneca, in the end AZ provided intelletual input and advice.
Impact There is an upcoming publication.
Start Year 2016
 
Description Astra Zeneca for studentship 
Organisation AstraZeneca
Department Research and Development AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution We are the host lab for an Astra Zeneca CTP student
Collaborator Contribution Collaboration on project and 3 month student hosting
Impact None yet
Start Year 2021
 
Description Birgitte Regenberg for eccDNA paper 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution This was a collaborative project to study the accumulation of circular DNA in ageing yeast cells. We provided the aged yeast cells and contributed to the interpretation of the data.
Collaborator Contribution The Regenberg lab performed circular DNA specific sequencing on the aged yeast samples, and generated a bioinformatic pipeline for accurately calling circular DNA from short read data.
Impact Manuscript on BioRxiv "Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae"
Start Year 2015
 
Description CEGX 
Organisation Cambridge Epigenetix
Country United Kingdom 
Sector Private 
PI Contribution Data generated by CASE PhD student as preliminary/pilot data for target validation of epigenetic changes in disease.
Collaborator Contribution Industrial CASE PhD studentship partner Cambridge Epigenetix (CEGX) provided help and advice in novel, proprietary technique and enabled student to perform this new method of epigenetic target validation during the placement period.
Impact PhD studentship in progress. Manuscript(s) will be generated from this work, possibly even targets for follow-on work and potential commercialisation as epigenetic biomarkers.
Start Year 2016
 
Description Christian Wolfrum - transgenerational epigenetic inheritance 
Organisation ETH Zurich
Department Institute of Food, Nutrition and Health
Country Switzerland 
Sector Academic/University 
PI Contribution Carried out transcriptome and methylome analysis of transgenerational epigenetic models
Collaborator Contribution Provided transgenerational epigenetic mouse models of high fat diet and cold shock
Impact Behavioural studies, nutrition, epigenetics, epigenomics, transcription
Start Year 2016
 
Description Deciduoma 
Organisation National Institute of Environmental Health Sciences
Department Reproductive and Developmental Biology Laboratory
Country United States 
Sector Public 
PI Contribution Characterisation of reproductive defects in older females
Collaborator Contribution Decidualisation model to assess the effect in the absence of an implanting embryo
Impact Collaborative publication (PMID: 28874785)
Start Year 2016
 
Description Development of computational methods for the quantification of biological variability 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of an algorithm based on Bayesian statistics that quantifies variability in steady state levels of mRNA from nanofluidics-based PCR.
Collaborator Contribution Development of an algorithm based on Bayesian statistics that quantifies variability in steady state levels of mRNA from nanofluidics-based PCR.
Impact It is a multi-disciplinary collaboration involving high end PCR technology and statistical modelling.
Start Year 2015
 
Description Rakyan for mouse rDNA 
Organisation Queen Mary University of London
Department Blizard Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of mouse rDNA CNV assay
Collaborator Contribution Mouse models and project lead
Impact None yet...
Start Year 2016
 
Description Role of Np95 in epigenetic reprogramming 
Organisation RIKEN
Country Japan 
Sector Public 
PI Contribution We are analysing the effects of Np95 deletion in zygotes and early embryos
Collaborator Contribution Contribution of unpublished conditional knockout in the key epigenetic regulator Np95
Impact The first results have been obtained and look quite interesting
Start Year 2008
 
Description Romain Barres 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Single cell multi-omics
Collaborator Contribution Human sperm from obese and control subjects
Impact Several datasets. Multi-disciplinary between epigenetics, multi-omics, human cohorts.
Start Year 2016
 
Description Uterine pathologies and maternal age 
Organisation University of Edinburgh
Department MRC Centre for Reproductive Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Molecular assessment of changes occurring in older females
Collaborator Contribution Pathological characterisation and assessment of uterine pathologies that become more frequent with age
Impact Collaboration established. Application for future funding in progress.
Start Year 2017
 
Description single cell TSCs 
Organisation University of Cambridge
Department Department of Obstetrics & Gynaecology
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration with Prof Steve Charnock Jones to form core of Centre of Trophoblast Research single cell transcriptomics profiles of mouse (and human) trophoblast stem cells under various conditions, as well as of placentas. Provided cells and tissues and culture media components to collaborator.
Collaborator Contribution Set up Drop-seq and optimising technique for nuclear RNA sequencing, required for syncytia. Performed sc-RNA-seq.
Impact Manuscript in preparation.
Start Year 2017
 
Title Consortium agreement 
Description Consortium agreement between the Babraham Institute and the Max Delbrück Centre on LifeTime EU 
IP Reference  
Protection Protection not required
Year Protection Granted 2019
Licensed No
Impact The LifeTime consortium is now up and running as a Coordination and Support Action supported by the EU
 
Description 15th International Curie Course on Epigenetics - Paris 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description 2019 Keystone Symposia on Single Cell Biology - Colorado 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description 3rd Revolutionizing Next-Generation Sequencing Conference - Belgium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description Article on JH lab research on WIRED website and in Quanta magazine 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on JH lab research following in-depth interview
Year(s) Of Engagement Activity 2017
URL https://www.wired.com/story/bacteria-may-rig-their-dna-to-speed-up-evolution/
 
Description Babraham Schools day 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Experiments on epigenetics for local 6th form schools
Year(s) Of Engagement Activity 2018
 
Description Biology of Aging Gordon Research Conference - Maine, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description British Yeast Group meeting 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk to scientists in this and other areas focused on yeast research
Year(s) Of Engagement Activity 2017
URL https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2017-british-yeast...
 
Description Cambridge Reproduction SRI, online workshop: "Interdisciplinary reflections on inheritance, development and environment" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact An online seminar that launched the research theme "Inheritance, Development and Environment" within the Cambridge Reproduction Strategic Research Initiative. Speakers from a range of departments across the University, encompassing molecular genetics, evolution theory and social science gave short presentations, followed by discussion.
Year(s) Of Engagement Activity 2020
URL https://www.repro.cam.ac.uk/events/interdisciplinary-reflections-inheritance-development-and-environ...
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Babraham Institute exhibit on the Epigenetic Ageing Clock presented at the Cambridge Science Festival, involving activities and question/answer interactions with members of the public
Year(s) Of Engagement Activity 2018
 
Description Cardiff Sixth Form Careers Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Online careers talk given to sixth form students. Covered careers in bioscience and personal career route as well as epigenetics broadly and specific research interests
Year(s) Of Engagement Activity 2021
 
Description Cold Spring Harbor Laboratory meeting: Stem Cell Biology, New York (USA) (VPG, CS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Participation in confenrence, poster presentation by both post-doctoral reserachers involved in this activity (VPG and CS) and engagement in discussions and broadening of scientific horizon
Year(s) Of Engagement Activity 2017
 
Description Comment to journal article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Wolf Reik spoke to journalist Kate Pasola about biological age and epigenetics as part of an article in Cosmopolitan titled 'I hacked my DNA in attempt to clear my acne - here's why I regret it'.
Year(s) Of Engagement Activity 2021
URL https://www.cosmopolitan.com/uk/beauty-hair/celebrity-hair-makeup/a35911493/dna-custom-skincare
 
Description Commnet to journal article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Wolf Reik, Michelle Linterman and Simon Walker spoke to Andy Martin, The Independent, about their work for a long read article "Who wants to live forever?". The article explores the biological processes that cause ageing, the effect on our immune system, and 'transient reprogramming'.
Year(s) Of Engagement Activity 2021
URL https://www.independent.co.uk/independentpremium/long-reads/anti-ageing-stay-young-science-b1859541....
 
Description Distinguished Lecture Speaker - University of Pennsylvania 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description EMBL Conference: Chromatin and Epigenetics - Heidelberg 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description EMBL Mammalian Genetics and Genomics Conference (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker at AMBL Conference Mammalian genetic and Genomic, Heidelberg, Germany
Year(s) Of Engagement Activity 2017
 
Description EU-Life meeting Principles of Homeostasis, Berlin (Germany) (VPG) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Participation and poster presentation at EU LIfe meeting "Principles of Homeostasis" held in Berlin, Germany (2017)
Year(s) Of Engagement Activity 2017
 
Description Epigenetics Escape Room Camb Fest Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Online escape room style engagement resource. Developed by researchers with puzzles linking to real life research. Event was run as part of Cambridge Festival with public audiences taking part and learning more about the Insitute and our epigenetics research
Year(s) Of Engagement Activity 2021
URL https://escape.babraham.ac.uk/
 
Description Epigenetics Escape Room Cambridge Science Festival event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Online escape room style engagement resource. Developed by researchers with puzzles linking to real life research. Event was run as part of Cambridge Science Festival with public audiences taking part and learning more about the Institute and our epigenetics research
Year(s) Of Engagement Activity 2021
URL https://escape.babraham.ac.uk/
 
Description Epigenetics Escape Room Swavesay Village College 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Online escape room style engagement resource. Developed by researchers with puzzles linking to real life research. Event was run as a facilitated session with students taking part in activites whilst also including careers and mini research talks to allow two-way engagement with students
Year(s) Of Engagement Activity 2021
 
Description Featured in DNA circles article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Online article discussing DNA circles (extrachromosomal DNA) featuring Jon Houseley (possible based on a press release sharing related work in this area issued in 2019)
Year(s) Of Engagement Activity 2020
URL https://cen.acs.org/pharmaceuticals/oncology/curious-DNA-circles-make-treating/98/i40
 
Description Form the Future School Careers Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 180 sixth form aged students attended this event (hosted at St Bedes School, Cambridge) where staff discussed and answered questions about what a bioscience career is like as well as discussing research interests. Teachers reported that students had increased their knowledge of such careers and especially highlighted the breadth of different roles the event highlighted to them.
Year(s) Of Engagement Activity 2021
 
Description GENIE network of C elegans researchers 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Joining this pan european network has allowed us to attend conferences, network with other C elegans labs across Europe and obtaining funding to organise a workshop on C elegans metabolic reconstruction.
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description GENiE workshop "Extending the consensus representation of C. elegans metabolism" 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact https://www.helmholtz-muenchen.de/genie-workshop-2017/program/index.html
Year(s) Of Engagement Activity 2018
URL https://www.helmholtz-muenchen.de/genie-workshop-2017/program/index.html
 
Description Genetics Society and BSDB Spring Meeting, Warwick, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker at annual spring meeting of the Genetics Society and British Society for Developmental Biology (BSDB) in Warwick, UK (2017)
Year(s) Of Engagement Activity 2017
 
Description Genetics Society annual autumn meeting - poster presentation RS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presentation of a poster with the newest data on this work. Meeting held in London, UK (2017).
Year(s) Of Engagement Activity 2017
 
Description Genome editing workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Workshop about Crispr genome editing at the Cambridge Science Festival
Year(s) Of Engagement Activity 2019
 
Description I'm a scientist 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Took part in online discussion forum events where students ask questions around careers in bioscience and research interests. Discussed career route, academic research landscape and epigenetic research. Was voted by students to win the 'zone'.
Year(s) Of Engagement Activity 2021
 
Description IFPA Meeting, Manchester, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at IFPA Meeting held in Manchester, UK (2017)
Year(s) Of Engagement Activity 2017
 
Description IMP Research Institute of Molecular Pathology - Vienna 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description INvited seminar at University of Copenhagen (Ecology and Evolution) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited seminar to University department in Copenhagen.
Year(s) Of Engagement Activity 2020
 
Description ISSHP Meeting, Berlin, Germany (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at ISSHP Meeting held in Berlin, Germany (2017)
Year(s) Of Engagement Activity 2017
 
Description Invited Seminar at Artios Pharma 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Invited seminar
Year(s) Of Engagement Activity 2018
 
Description Invited seminar at CRUK Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited seminar at CRUK Manchester.
Year(s) Of Engagement Activity 2020
 
Description Invited seminar at Ecole Normale Supérieure de Lyon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Seminar to University department in Lyon
Year(s) Of Engagement Activity 2021
 
Description Invited speaker at SciLifeLab, Stockholm 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecture
Year(s) Of Engagement Activity 2019
 
Description Invited speaker invitation - Grand Rapids, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description Invited talk at Cambridge Innovation Forum - "Challenging Ageing" event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact One of 4 invited speakers at the Cambridge Innovation Forum - "Challenging Ageing" event. Involved a talk and then a panel discussion with audience Q&A on ageing.
Year(s) Of Engagement Activity 2019
URL https://cambridge.inno-forum.org/event/challenging-ageing/
 
Description Invited talk at Stem Cells UK meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture to Stem Cells UK meeting.
Year(s) Of Engagement Activity 2020
 
Description Keynote speaker, CTR Anniversary Meeting, Cambridge, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Keynote lecture at 10th Anniversary Meeting of the Centre for Trophoblast Research, University of Cambridge (2017)
Year(s) Of Engagement Activity 2017
 
Description Life2019 Conference - Netherlands 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description Media comment on research related to ageing and rejuvenation 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Contribution of a comment on research reprogramming cells from an 114 year old individual in Newsweek article: Scientists Have Reset Cells From a Supercentenarian, Giving Clues to Their Extreme Longevity,
Year(s) Of Engagement Activity 2020
URL https://www.newsweek.com/supercentenarian-cells-reset-aging-longevity-1494497
 
Description Meeting organiser, Reproduction and Development, Cambridge 2018 (MH) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Co-organisation of meeting, Reproduction and Development, held in Cambridge, UK (2018).
Year(s) Of Engagement Activity 2018
 
Description Organisation of C.elegans Cambridge local area meetings 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact An audience of about 10-15 science labs from around the Cambridge area attend these events, including many PhD students and postdocs. The aim of these meetings is dissemination of techniques and science as well as networking.
Year(s) Of Engagement Activity 2015,2017,2018
 
Description Panel discussion for NCCPE Engage Conference 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was a panel member for the session: "Public dialogues: A valuable tool for Higher Education Institutes?" at the NCCPE Engage Conference 2020.
Year(s) Of Engagement Activity 2020
URL https://babraham.ac.uk/blog/2021/01/public-dialogue-spur-genome-editing-engagement
 
Description Partcipation in The Future of Ageing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A representative of the Casanueva lab attended a debate on the future of gein at London School of Economics geared towards general public.
Year(s) Of Engagement Activity 2018
 
Description Podcast with Dr Kat Arney on the impact of placentation and maternal age on reproductive outcome 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Podcast as descibed above
Year(s) Of Engagement Activity 2017
 
Description Postgraduate course Epigenetics in Reproductive Biology, University of Murcia, Spain (VPG) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited talk and workshop participation as part of postgraduate course on reproductive epigenetics
Year(s) Of Engagement Activity 2016,2017
 
Description Press article on JH lab research in Quanta and WIRED 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I was interviewed about the research in my lab, particularly the work in PLOS Biology (PMID 28654659), and this was written up into an article for Quanta magazine. This was then picked up and re-distributed to a much wider audience by WIRED.
Year(s) Of Engagement Activity 2018
URL https://www.wired.com/story/bacteria-may-rig-their-dna-to-speed-up-evolution/
 
Description Protein Challenge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Students are given the opportiunity to become immersed in a hands-on research project where they carry out practical experiments involving protein assaying. They then produce a scientific poster based on their results and present these. The porgramme takes place over a number of sessions with support for the students to develop their wider research skills and understanding of research ethics.
Year(s) Of Engagement Activity 2021
 
Description Radio interview DeutschlandFunk 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio Interview for DeutschlandFunk on the impact of maternal age on pregnancy success, irrespective of the increased risk of defects in the egg
Year(s) Of Engagement Activity 2017
URL http://www.deutschlandfunk.de/alter-des-uterus-entscheidend-junges-glueck-in-jungen.676.de.html?dram...
 
Description Royal Society Summer Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Babraham Institute exhibit on the Epigenetic Ageing Clock as invited entry presented at the Royal Society Summer Exhibition, involving activities and question/answer interactions with members of the public, fellows of the Royal Society, policymakers
Year(s) Of Engagement Activity 2018
 
Description Savile Club epigenetics talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation about epigenetics at the London Savile Club
Year(s) Of Engagement Activity 2018
 
Description Sophianum School collaboration - Technasium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact The Babraham Institute is continuing to coordinate activities supporting its commitment as a signatory of the Concordat on Openness on Animal Research. Institute staff, including animal unit managers, have been working closely with a school in the Netherlands to prepare and launch the Institute's contribution to the national 'Technasium' education programme, which aims to draw together students and industry.

Two projects, developed in collaboration with the Institute's Public Engagement team and teachers from the Sophianum School in Gulpen, will challenge students to research and design systems to improve the efficiency and safety of animal care systems. A third project will require the students to research how legislation regulating the use of animals in science, as well as public opinion, can vary throughout Europe and the world.

A two-day visit on 19th & 20th May will kick-start a 10-week programme for the 15-year old students, who will work in teams and compete to design the best solutions to the challenges. The Institute's animal technicians will monitor student progress by commenting on YouTube videos posted fortnightly by the teams. Regular video calls into the animal unit and the Institute's laboratories will allow live discussion between the students, the animal technicians and the scientists who use animals as part of their research.

The challenge projects will finish in July, with the winning Sophianum team coming to the Babraham Institute as part of their prize. The students will visit Institute animal facilities and will get a chance to see the award-winning camera system which displays live feeds from the facility - allowing groups to appreciate first-hand both the animal care environment and the nature of working within an animal research unit.

This pilot project will also involve sixth-form students at the school who will learn about the Institute's research and take part in workshops to discuss the ethics of the use of animals in science. The Institute has been running ethics workshops for secondary and sixth form students since 2005, with contributions from Understanding Animal Research, the European Animal Research Association and the Institute of Animal Technology.

The success of the Technasium project will be evaluated by both the Institute and Sophianum School, with a view to developing future challenges.
Year(s) Of Engagement Activity 2017,2018
 
Description Sophianum poster workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact A scientific poster workshop for the Sophianum school in the Netherlands
Year(s) Of Engagement Activity 2019
 
Description Sophianum sixth form project judging 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Sixth form students wrote scientific projects which were then judged
Year(s) Of Engagement Activity 2019
 
Description Sophianum visit to BI 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact School visit by dutch school classes
Year(s) Of Engagement Activity 2019
 
Description St Catharines Society Visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A presentation and discussion at the St Catherine's society
Year(s) Of Engagement Activity 2019
 
Description Talk at 2021 Sino-British Young Leaders Innovation Forum 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The forum was attended by 50 participants and featured 9 talks from academic scholars and business experts from both China and UK. It was followed by discussions on open science, measures to publicise existing collaborations between the two countries and identify areas of complementarity, importance of cooperation on science and technology in the post-pandemic era and funding opportunities for young scientists in both countries to aid collaborative research
Year(s) Of Engagement Activity 2021
 
Description Talk at British Yeast Group by Lab member Ryan Hull 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Conference presentation at the British Yeast Group meeting
Year(s) Of Engagement Activity 2018
 
Description Talk at CNRS meeting "Genome instability: when RNA meets chromatin" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk at conference "Genome instability: when RNA meets chromatin"
Year(s) Of Engagement Activity 2019
URL https://www.insb.cnrs.fr/fr/genome-instability-when-rna-meets-chromatin
 
Description Talk at Cambourne Library 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 15 general audience attended an Epigenetics presentation and discussion
Year(s) Of Engagement Activity 2018
 
Description Talk at DNA Replication as a Source of DNA Damage Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk to other members of research community.
Year(s) Of Engagement Activity 2017
URL https://www.fusion-conferences.com/conference67.php
 
Description Talk at EMBO Evolution and Ecology meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk and poster presentation at EMBO meeting
Year(s) Of Engagement Activity 2018
URL https://www.embl.de/training/events/2018/EAE18-01/
 
Description Talk at EpiChrom 2019 by lab member Ryan Hull 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk at EpiChrom 2019 meeting
Year(s) Of Engagement Activity 2019
URL https://www.scilifelab.se/epichrom-2019/
 
Description The Ageing Cell Conference, Cambridge, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited talk at The Ageing Cell Conference held in Cambridge, UK (2017)
Year(s) Of Engagement Activity 2017
 
Description UKRI launch 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact UKRI launch event 2018
Year(s) Of Engagement Activity 2018
 
Description Undergraduate Work Placement Programme 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Undergraduate students completed a 4 week online work experience placement in our laboratories with a programme of talks about life as a researcher and careers in science.
Year(s) Of Engagement Activity 2020
 
Description Weert College ethics workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact This was a scientific ethics workshop for a school in the Netherlands
Year(s) Of Engagement Activity 2019
 
Description Weert College presentation judging 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Students were making scientific presentations which were then judged
Year(s) Of Engagement Activity 2019
 
Description Wellcome Trust Workshop on NEURONAL MATURATION: London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk
Year(s) Of Engagement Activity 2019
 
Description Whittlewomen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation to local women's group
Year(s) Of Engagement Activity 2019
 
Description Women's Institute visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Visit by members of the Women's Institute for a discussion and workshop on Epigenetics
Year(s) Of Engagement Activity 2019