Designing oilseeds for nutrition and health
Lead Research Organisation:
Rothamsted Research
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The primary objective of this project is to increase the nutritional composition of oilseeds by genetic modification. This will involve iterative metabolic engineering, underpinned by a dedicated lipidomics platform. Efficacy will be determined through collaborations with external partners, using animal feeding studies.
The objectives of this research are:
1. The accumulation of 15% EPA and/or 10% DHA in transgenic Camelina sativa, validated by ACRE-approved field trials
2. To identify new enzyme activities which contribute to enhanced accumulation of non-native fatty acids in transgenic plants
3. To establish a dedicated and specific lipidomic platform for the systematic analysis of our transgenic plants, and use these datasets to populate metabolic models
4. To define the role of endogenous very long chain fatty acids in plant development
5. To identify genetic factors that significantly impact on the oil composition and content of oilseeds.
6. To incorporate information on lipid catabolism into systems analyses of lipid metabolism
The objectives of this research are:
1. The accumulation of 15% EPA and/or 10% DHA in transgenic Camelina sativa, validated by ACRE-approved field trials
2. To identify new enzyme activities which contribute to enhanced accumulation of non-native fatty acids in transgenic plants
3. To establish a dedicated and specific lipidomic platform for the systematic analysis of our transgenic plants, and use these datasets to populate metabolic models
4. To define the role of endogenous very long chain fatty acids in plant development
5. To identify genetic factors that significantly impact on the oil composition and content of oilseeds.
6. To incorporate information on lipid catabolism into systems analyses of lipid metabolism
Planned Impact
unavailable
Organisations
People |
ORCID iD |
| Johnathan Napier (Principal Investigator) |
Publications
Arnold T
(2015)
Iron and zinc isotope fractionation during uptake and translocation in rice (Oryza sativa) grown in oxic and anoxic soils
in Comptes Rendus. Géoscience
Baker A
(2015)
Peroxisomal ABC transporters: functions and mechanism.
in Biochemical Society transactions
Bryant FM
(2016)
ACYL-ACYL CARRIER PROTEIN DESATURASE2 and 3 Are Responsible for Making Omega-7 Fatty Acids in the Arabidopsis Aleurone.
in Plant physiology
Chen GQ
(2016)
Expression of Castor LPAT2 Enhances Ricinoleic Acid Content at the sn-2 Position of Triacylglycerols in Lesquerella Seed.
in International journal of molecular sciences
Chueasiri C
(2014)
Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development.
in PloS one
Craddock CP
(2015)
Regulation of endomembrane biogenesis in arabidopsis by phospatidic acid hydrolase.
in Plant signaling & behavior
Craddock CP
(2017)
Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity.
in The Plant journal : for cell and molecular biology
| Description | Better and more nutritious food from seeds |
| Exploitation Route | Research is on going.... |
| Sectors | Agriculture Food and Drink |
| Description | First UK GM field trial of a novel nutritional oil trait (2014- ), demonstrating the feasibility of the conceptual approach outlined in the proposal |
| First Year Of Impact | 2014 |
| Sector | Agriculture, Food and Drink,Other |
| Impact Types | Societal Economic |
| Description | GCRF-IAA Award |
| Amount | £34,469 (GBP) |
| Funding ID | BB/GCRF-IAA/18 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 02/2017 |
| Title | PRODUCTION OF OMEGA-3 LONG CHAIN POLYUNSATURATED FATTY ACIDS |
| Description | A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences. |
| IP Reference | CA2869738 |
| Protection | Patent application published |
| Year Protection Granted | 2013 |
| Licensed | Commercial In Confidence |
| Impact | Establishment of a IP-protected business proposition based around GM camelina making omega-3 fish oils |