Pathogen diversity, host specificity and virulence
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
This project will examine the diversity of pathogen populations and identify factors that contribute to virulence and host tropism, define their mode of action and use this knowledge to develop strategies to detect, treat and prevent infections.
Organisations
- University of Edinburgh, United Kingdom (Lead Research Organisation)
- Fonds de la Recherche Scientifique (Collaboration)
- Zoetis (Collaboration)
- James Hutton Institute (Collaboration)
- Public Health England, United Kingdom (Collaboration)
- Utrecht University (Collaboration)
- Hungarian Academy of Sciences (MTA) (Collaboration)
- AB Vista (Collaboration)
- National Veterinary Institute (Collaboration)
- Animal Health Service (Collaboration)
- Boehringer Ingelheim, Germany (Collaboration)
- Wageningen University, Netherlands (Collaboration)
- Animal and Plant Health Agency (Collaboration)
- National Food Chain Safety Office (Collaboration)
- University of Hokkaido, Japan (Collaboration)
- Animal and Plant Quarantine Agency (Collaboration)
- International Livestock Research Institute (ILRI) (Collaboration)
- Konkuk University (Collaboration)
- Government of Canada (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Chinese Academy of Agricultural Sciences (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- University Libre Bruxelles (Université Libre de Bruxelles ULB) (Collaboration)
- Texas Technical University (Collaboration)
- Charoen Pokphand Group (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- Quadram Institute Bioscience (Collaboration)
- Animal Health Research Institute (Collaboration)
- Erasmus University Medical Center, Netherlands (Collaboration)
- Scotland's Rural College (Collaboration)
- Wellcome Trust, LONDON (Collaboration)
- Experimental Zooprophylactic Institute of the Venezie (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- Biomathematics and Statistics Scotland (BioSS) (Collaboration)
- Moredun Research Institute (Collaboration)
- US Geological Survey (Collaboration)
Publications
Abbas AH
(2018)
The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense.
in Genome biology and evolution
Akram KM
(2018)
An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.
in Mucosal immunology
Alfituri OA
(2019)
Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei.
in Parasite immunology
Amzati GS
(2018)
Mitochondrial phylogeography and population structure of the cattle tick Rhipicephalus appendiculatus in the African Great Lakes region.
in Parasites & vectors
Bacigalupe R
(2017)
Population Genomics of Legionella longbeachae and Hidden Complexities of Infection Source Attribution.
in Emerging infectious diseases
Bett C
(2018)
Both murine host and inoculum modulate expression of experimental variant Creutzfeldt-Jakob disease.
in The Journal of general virology
Bonsaglia ECR
(2018)
Molecular epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) isolated from milk of cows with subclinical mastitis.
in Microbial pathogenesis
Boyle A
(2017)
Strain Typing of Prion Diseases Using In Vivo Mouse Models.
in Methods in molecular biology (Clifton, N.J.)
| Description | 1. Machine learning to predict zoonotic potential and host attribution We have applied a machine learning approach to analyse the gene content of bacterial pathogens that are found in multiple animal hoists including humans. Based on this approach it is possible to score the likely animal or human source of an isolate and its potential to infect and or cause disease in another host, including zoonotic potential in humans. The approach has value for source attribution studies for example defining the source of these bacteria in watercourses or food. It also helps identify the genes that facilitate infection of specific hosts. We can now test the value of the machine learning predictions using experimental approaches such as the highlight described below. 2. A sequence-based method to examine multi-strain infection dynamics in individual animals We have developed a sequence-based approach to study the survival of different Salmonella serovars simultaneously in cattle. Salmonella is a pathogen that infects both cattle and humans. There are over 2600 types or serovars of Salmonella, many of which can survive within the lymphatic system of cattle. Peripheral lymph nodes of cattle contaminated with Salmonella can enter the food chain via ground beef products and improper cooking of these foods can result in infections in humans. It is important to determine whether some Salmonella serovars are better than others at surviving within cattle to determine if some serovars pose a greater threat to human health than others. This will enable researchers to develop appropriate vaccines and interventions to stop the transmission of Salmonella to humans. Some genes of Salmonella vary naturally in their sequence between different serovars and by using variation in these genes as markers, it is possible to identify and quantify serovars present in a mixed-population. Notably, all the different Salmonella serovars tested could be found in the peripheral lymph nodes, indicating that they all compromise food safety and may have equivalent invasive potential in cattle. We aim to apply for funding to test predicted scoring as defined above using this methodology. 3. A roadmap for zoonotic TB The first ever global Zoonotic TB roadmap. A roadmap to combat Zoonotic Tuberculosis was launched in 2017 at the Union World Conference on Lung Health in Mexico. Zoonotic Tuberculosis (TB) is a form of tuberculosis in people caused by Mycobacterium bovis, which is often transmitted to humans through contact with infected animals, mainly cattle, and consumption of infected products. Ending the global TB epidemic is part of the goals set by the United Nations, aiming at inclusive, multidisciplinary approaches to improving health throughout the world by 2030. Dr Adrian Muwonge chairs the Zoonotic TB section at the International Union Against Tuberculosis and Lung Disease (The Union) that has been key to developing the roadmap which defines 10 key priority areas for limiting the impact of this disease on humans and their livestock and calls on stakeholders such as government, donors, academia, non-governmental organisations and private partnerships to action. The roadmap advises stakeholders to prioritise: (1) Mitigation of risk of transmission of zoonotic TB; (2) Strengthening diagnostic capability; (3) Access to timely diagnosis and effective treatment; (4) Fostering inter-sectoral collaboration. 4. The epidemiology of bovine tuberculosis in Cameroon Based on abattoir sampling of 2346 cattle in 4 Regional abattoirs in Cameroon we have identified 255 M. bovis isolates in 97 unique genotypes, 19 of which have not previously been described. This represents the most diverse M. bovis population reported in Africa to date. The patterns of diversity are also different between regions possibly reflecting livestock movement networks and cross-border trade introducing a large number of new genotypes. This correlates with a separate analysis of the livestock trade network which shows a large interconnected network of trade in Northern Cameroon compared to a much more isolated trade network in the NW Region. The work is generating a better understanding of how this disease is transmitted between hosts in order to develop guidelines for stakeholders that should help reduce such transmission. 5. Progress on understanding the pathogenesis of Lawsonia intracellularis (LI) Advances have recently been made in 3 areas: pathogen diversity, host pathogenesis and evaluation of vaccine efficacy. Through the efforts of a BBSRC-funded PhD student (BB/L01680X/1) we have acquired a further 30 LI genome sequences from faecal and ileum samples from clinically infected pigs in the UK, Europe, South America and Korea as well as from horse isolates and historical isolates. Further to these we have also acquired the data for 18 microbiomes that are associated with different severity of PPE clinical signs. This work has allowed us i) to generate novel diagnostic PCR assays to distinguish the vaccine strain from field strains, ii) to generate novel diagnostics including lateral flow assays and ELISA test and iii) establish the tools to test for associations between LI genotype and clinical signs in field samples. With the establishment of an in vitro culture system for LI in epithelial cells we have now identified how LI may alter the regulation of NFKB and autophagy early during infection. In particular this work exploits cells lines edited in specific signalling components. This work will pave the way towards a better understanding how this intracellular pathogen is able to manipulate a key innate immune signalling component for its replication and survival. To further enhance molecular and cell lineage investigations a novel LI infection model in intestinal organoid has been also developed. Finally, in line with the expertise we have acquired on the intestinal integrity during LI infection we have contributed to evaluation of the efficacy of novel LI vaccine. Our work on Lawsonia is with commercial companies. |
| Exploitation Route | XX |
| Sectors | Agriculture, Food and Drink,Education,Healthcare |
| Description | It is an early stage in this programme but the zoonotic TB roadmap lays down priority areas that impact on a broad range of stakeholders in terms of this important disease in affected countries. There is also considerable interest from the commercial sector in our work on specific pathogens for development of new diagnostic tests and vaccines. We are also in discussion with two companies about the application of machine learning methods to interrogate complex genomic data for prediction. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink,Healthcare |
| Impact Types | Cultural,Economic,Policy & public services |
| Description | Alberta Prion Research Institute's Explorations Program Round VI |
| Amount | $493,700 (CAD) |
| Funding ID | PEX17009 |
| Organisation | Alberta Prion Research Institute |
| Start | 07/2017 |
| End | 06/2020 |
| Description | BBSRC Future Leader Fellowship |
| Amount | £304,886 (GBP) |
| Funding ID | BB/P007767/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 03/2019 |
| Description | BBSRC-A strategic approach to identifying and combating porcine reproductive and respiratory syndrome virus outbreaks and other porcine viral diseases |
| Amount | £983,771 (GBP) |
| Funding ID | BB/R013187/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | BBSRC-SFI-Tackling a multi-host pathogen problem - phylodynamic analyses of the epidemiology of M. bovis in Britain and Ireland |
| Amount | £448,073 (GBP) |
| Funding ID | BB/P010598/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2020 |
| Description | BBSRC_Understanding the CD163 - PRRS virus interaction to improve genetic engineering for resistance |
| Amount | £674,353 (GBP) |
| Funding ID | BB/R004463/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2020 |
| Description | Boehringer Ingelheim The PCV2 European Research Award |
| Amount | € 25,000 (EUR) |
| Organisation | Boehringer Ingelheim |
| Department | Boehringer Ingelheim |
| Sector | Private |
| Country | Canada |
| Start | 02/2017 |
| End | 04/2018 |
| Description | Carnegie Research Incentive Grant |
| Amount | £9,886 (GBP) |
| Organisation | Carnegie Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 07/2018 |
| Description | Carnegie Trust Research Incentive Grant |
| Amount | £9,740 (GBP) |
| Organisation | Carnegie Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2019 |
| Description | Center for Tropical Livestock Health and Genetics |
| Amount | £15,000,000 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 02/2017 |
| End | 03/2020 |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £384,966 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | EU-Dynamics of avian influenza in a changing world |
| Amount | £403,373 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 08/2017 |
| End | 09/2021 |
| Description | Food Standards Scotland Open Tender |
| Amount | £120,000 (GBP) |
| Funding ID | CRF:MRI/104/17 |
| Organisation | Government of Scotland |
| Department | Food Standards Agency (FSA), Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 06/2019 |
| Description | Machine-learning to predict and understand the zoonotic threat of E. coli O157 isolates |
| Amount | £421,490 (GBP) |
| Funding ID | BB/P02095X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2020 |
| Description | Wellcome Trust Collaborative Award |
| Amount | £2,021,766 (GBP) |
| Funding ID | 206815/Z/17/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2022 |
| Description | Wellcome Trust Pathfinder Award |
| Amount | £129,709 (GBP) |
| Funding ID | 204521/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 11/2018 |
| Description | he role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken. |
| Amount | £1,144,442 (GBP) |
| Funding ID | BB/P022049/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 12/2020 |
| Title | ELispot for PCV2 |
| Description | The assay is able to detect a cellular immune response to PCV2. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Improvement of vaccine efficacy assessment. |
| Title | Strategy for quantifying individual bacterial strains during mixed infections |
| Description | We devised a novel strategy to follow the fate of individual bacterial strains during mixed infections. Specifically, we wished to follow the fate of multiple Salmonella enterica serovars during colonisation of the bovine host. These are indistinguishable by culture, and while they can be specifically detected by serology, quantification of numbers of each serovar during mixed infection would involve analysis of many hundreds or thousands of individual colonies. We devised a method based on massively-parallel sequencing of a polymorphic allele (rpoB), whereby sequence reads can be used to identify the strain present (based on single nucleotide polymorphisms specific to each strain) and the number of sequence reads can be taken as a measure of the abundance of the cognate strain. Using this method we were able to simultaneously define the fate of 12 different S. enterica strains during infection of cattle, including as they colonised the gut over time and spread from the gut to the lymphatic system and other tissues. This 3R approach should allow phenotypes to be derived with reduced use of animals in experiments and could, for example, be used to see if vaccine-induced responses are effective in control of all the different members of a bacterial population present - in this case toward a pan-serovar cross-protective vaccine. A manuscript reporting these findings was published in late 2017 (Vohra et al). Though a direct output of BBSRC responsive-mode funding, the project was underpinned by core-strategic grants from 2012 and 2017 (e.g. via the involvement of core-funded staff in animal studies) and a BBSRC US-UK partnering award, where the ideas for following serovars based on massively-parallel sequencing of rpoB and ileS were jointly developed. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Too early to say, but the method has the potential to reduce animal use in evaluating the cross-protective efficacy of vaccines or treatments as it enables many strains to be tested at once in a single animal rather than in separate groups that each receive a single strain. |
| Title | Avianbase: a community resource for bird genomics |
| Description | The Avianbase Project is an initiative led by the Roslin Institute in collaboration with the Avian Phylogenomics Consortium and Ensembl to make the initial sequence and annotation available for 48 bird species within the Ensembl framework. The Avianbase Project is using the Ensembl infrastructure to share data brought together by the Avian Phylogenomics Consortium (as part of the Avian Genome Consortium) for 48 birds. Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released by the Avian Phylogenomics Consortium. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | The Avianbase project was overviewed in the paper of 2015 (Lél Eöry, M Thomas P Gilbert, Cai Li, Bo Li, Alan Archibald, Bronwen L Aken, Guojie Zhang, Erich Jarvis, Paul Flicek and David W Burt (2015) Avianbase: a community resource for bird genomics. Genome Biology 16:21) which has been sited by over 18 times. It provides a valuable one-stop-shop to access a wealth of Avian genomic information to allow easy interrogation of genotype across species. |
| URL | http://avianbase.narf.ac.uk/index.html |
| Title | Comparative ribosome profiling uncovers a dominant role for translational control in Toxoplasma gondii |
| Description | We deposited in ToxoDB, which is a database of Apicomplexan parasite genome and genomic data (such as RNA-seq, DNA-seq, proteomics, etc), whole genome ribosome profiling and RNA-sequencing data of intracellular and extracellular parasites to facilitate the identification of parasite genes that are essential for intercellular transmission. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | This is the first genome-wide ribosome profiling data on any strain of Toxoplasma and is helping research understand the role of translational regulation in the parasites's lifecycle. IT has informed current ongoing research in various aspects of Toxoplasma biology in many labs. |
| Description | Bovine Tuberculosis sequencing and modelling collaboration |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Help with analysis of bovine tuberculois sequences with Phylodynamics computational techniques |
| Collaborator Contribution | Lead of Tb project, collection of bovine Tb sequences and other modelling expertise |
| Impact | Papers resulting: Trewby et al (2016) "Use of bacterial whole-genome sequencing to investigate local persistence and spread in bovine tuberculosis" Epidemics, Vol 14 March 2016, Pages 26-35 Crispbell (2017) "Using whole genome sequencing to investigate transmission in a multi-host system: bovine tuberculosis in New Zealand" BMC Genomics 2017 Feb 16;18(1):180 Successful grant application due to start April 2017: Bilateral BBSRC-SFI: Tackling a multi-host pathogen problem - phylodynamic analyses of the epidemiology of M. bovis in Britain and Ireland PI: Professor Rowland Kao:University of Glasgow BB/P010598/1 |
| Start Year | 2014 |
| Description | Centre for Tropical Livestock Genetics and Health (CTLGH) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Research contribution to the CTLGH result framework. |
| Collaborator Contribution | Research links and collaboration with its member partners in the UK and Africa. |
| Impact | No output to report yet. |
| Start Year | 2017 |
| Description | Centre for tropical livestock genetics and health (CTLGH) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Mick Watson is co-leading programme 5 (informatics and bioresources) programme of CTLGH which aims to collect data on genotype and phenotype into a central database which can subsequently be mined for useful associations. So far we have ensured that scientists have access to the latest high performance computing environment for research, we have analysed and continue to analyse hundreds of farm animal genomes from LMIC countries, and we have built the data portal (http://data.ctlgh.org) |
| Collaborator Contribution | The partners are involved in all programmes, which include:Program 1: Harnessing genetic variability among indigenous and exotic breeds of cattle (as well as their crosses) to develop genetic and genomic tools that will be used to improve productivity under harsh tropical conditions and to mitigate the impact of cattle on climate change. Program 2: Harnessing genetic variability in tropical productivity and adaptation among various breeds of Chickens. Program 3: Development and application of precision breeding (through novel reproductive and germplasm technologies) to achieve step changes in livestock genetic improvement. Program 4: Understanding the genetic and molecular mechanisms underlying the tolerance of certain cattle and poultry breeds to tropical diseases and pests. Program 5: A shared global data and biological sample resource to support continued research and development on tropical livestock genetics and health. |
| Impact | The data portal so far: http://data.ctlgh.org The collaboration is multi-disciplinary, bringing together geneticists, parasitologists, virologists, epidemiologists and data scientists together. |
| Start Year | 2016 |
| Description | Centre for tropical livestock genetics and health (CTLGH) |
| Organisation | Scotland's Rural College |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Mick Watson is co-leading programme 5 (informatics and bioresources) programme of CTLGH which aims to collect data on genotype and phenotype into a central database which can subsequently be mined for useful associations. So far we have ensured that scientists have access to the latest high performance computing environment for research, we have analysed and continue to analyse hundreds of farm animal genomes from LMIC countries, and we have built the data portal (http://data.ctlgh.org) |
| Collaborator Contribution | The partners are involved in all programmes, which include:Program 1: Harnessing genetic variability among indigenous and exotic breeds of cattle (as well as their crosses) to develop genetic and genomic tools that will be used to improve productivity under harsh tropical conditions and to mitigate the impact of cattle on climate change. Program 2: Harnessing genetic variability in tropical productivity and adaptation among various breeds of Chickens. Program 3: Development and application of precision breeding (through novel reproductive and germplasm technologies) to achieve step changes in livestock genetic improvement. Program 4: Understanding the genetic and molecular mechanisms underlying the tolerance of certain cattle and poultry breeds to tropical diseases and pests. Program 5: A shared global data and biological sample resource to support continued research and development on tropical livestock genetics and health. |
| Impact | The data portal so far: http://data.ctlgh.org The collaboration is multi-disciplinary, bringing together geneticists, parasitologists, virologists, epidemiologists and data scientists together. |
| Start Year | 2016 |
| Description | Charoen Pokphand (CP) group |
| Organisation | Charoen Pokphand Group |
| PI Contribution | Charoen Pokphand (CP) group are a large Asian conglomerate with an interest in farming, food production and feed additives. They have placed one of their staff members with me for PhD training, fully funded by them. We are training the staff member in laboratory and bioinformatics techniques related to microbiome research in chickens. |
| Collaborator Contribution | CP provide access to large chicken flocks both in at their farms and in their production facility. This enables us to study chicken breeds in the actual environments in which they live throughout Asia. |
| Impact | This is a multi-disciplinary project involving both laboratory and computational techniques. The major outcome so far include a review paper (http://aem.asm.org/content/early/2018/01/29/AEM.02627-17.abstract) and the technology transfer from our group into the commercial partner. |
| Start Year | 2017 |
| Description | Collaboration with AB Vista |
| Organisation | AB Vista |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We are researching the activity of ovodefensins, naturally-occurring egg peptides with antimicrobial properties. With BBSRC LINK funding we are exploring the activity of diverse ovodefensins from multiple avian species, dissecting their structure and mode of action, and exploring their capacity to act as growth promoters and novel therapeutics. |
| Collaborator Contribution | AB Vista have made a substantial cash contribution to the LINK project (c. £460k) and also provide access to natural populations of broilers for feed trials using diets supplemented (or not) with Trichoderma-expressed ovodefensins. They also support analysis of the impact of such diets on intestinal microbiota and metabolites. |
| Impact | Commercially sensitive and to be disclosed following scrutiny for Intellectual Property. |
| Start Year | 2012 |
| Description | Collaboration with Boehringer Ingelheim |
| Organisation | Boehringer Ingelheim |
| Country | Germany |
| Sector | Private |
| PI Contribution | The collaboration is to advance diagnostics in relation to specific bacterial infections in pigs. We are carrying out basic science investigating antigens and immune responses |
| Collaborator Contribution | The company is providing reagents and expertise in this subject area |
| Impact | Part-funded PhD studentship |
| Start Year | 2017 |
| Description | Collaboration with Public Health England |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provision of animal and human STEC for sequencing, working with PHE to analyse strain phylogeny and epidemiology. We have contributed through further analysis of long read strain sequences to understand changes in strains that occur during outbreaks. We have co-upervised 2 PhD students on STEC bioinformatics projects. |
| Collaborator Contribution | Reduced rate sequencing of STEC, analysis of data, provision of metadata. Co-publication |
| Impact | Publications as in main list |
| Start Year | 2013 |
| Description | Collaboration with Texas Tech University |
| Organisation | Texas Tech University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Partner in this BBSRC US-UK Partnering Award related to Salmonella and E. coli infections in food-producing animals. |
| Collaborator Contribution | We hosted a visiting postdoctoral research fellow (Marie Bugarel from TTU) in 2015 and provided training in methods to study the basis of Salmonella virulence (inc. mutagenesis, cell-based assays & in vivo models). Drs Bugarel and Loneragan were co-authors on our manuscript describing the use of massively-parallel sequencing of polymorphic alleles to track the fate of Salmonella enterica serovars following inoculation of cattle. |
| Impact | A manuscript relating to a novel method to follow the fate of Salmonella enterica serovars during mixed infections was published in Applied and Environmental Microbiology in late 2017. This arose, in part, from the collaboration funded by a BBSRC US-UK partnering award (see tools), with resources from BBSRC- and Zoetis-funded project (BB/K015524/1) and core strategic grants to the Roslin Institute awarded in 2012 and 2017. |
| Start Year | 2014 |
| Description | Collaboration with USDA Nebraska |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | Exchange of STEC sequence information. Analysis of PacBio long read sequencing of human and cattle isolates |
| Collaborator Contribution | Exchange of STEC sequence information. Carrying out of PacBio sequencing. Discussion of feedlot trials for E. coli O157 vaccine |
| Impact | Publications are provided in main list |
| Start Year | 2014 |
| Description | Collaboration with the Quadram Institute |
| Organisation | Quadram Institute Bioscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a joint project with the Quadram Institute, where the lead Principal Investigator is Dr Rob Kingsley. The BBSRC contribution to our component of the project is £123,594. It is envisaged that we will evaluate the virulence of variants of Salmonella enterica serovar Typhimurium in porcine models, both to quantify the magnitude and duration of intestinal colonisation in orally challenged pigs and the ability of strains to induce secretory and inflammatory responses in a porcine surgical model. |
| Collaborator Contribution | The Quadram Institute will select Salmonella strains for testing in vivo, based on analysis of their genome sequences, transcriptomes and the phenotypes of the strains in cell-based assays. |
| Impact | None at this stage. We await strains for testing. |
| Start Year | 2015 |
| Description | EPIC Consortium |
| Organisation | Biomathematics and Statistics Scotland (BioSS) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Roslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur). |
| Collaborator Contribution | The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC. |
| Impact | Multi-institution, multi-disciplinary collaboration |
| Start Year | 2016 |
| Description | EPIC Consortium |
| Organisation | James Hutton Institute |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Roslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur). |
| Collaborator Contribution | The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC. |
| Impact | Multi-institution, multi-disciplinary collaboration |
| Start Year | 2016 |
| Description | EPIC Consortium |
| Organisation | Moredun Research Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Roslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur). |
| Collaborator Contribution | The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC. |
| Impact | Multi-institution, multi-disciplinary collaboration |
| Start Year | 2016 |
| Description | EPIC Consortium |
| Organisation | Scotland's Rural College |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Roslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur). |
| Collaborator Contribution | The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC. |
| Impact | Multi-institution, multi-disciplinary collaboration |
| Start Year | 2016 |
| Description | EPIC Consortium |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Roslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur). |
| Collaborator Contribution | The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC. |
| Impact | Multi-institution, multi-disciplinary collaboration |
| Start Year | 2016 |
| Description | Industrial partnership with Zoetis Animal Health |
| Organisation | Zoetis |
| Country | United States |
| Sector | Private |
| PI Contribution | Identification of conserved antigens expressed during infection which represent candidate vaccine components |
| Collaborator Contribution | Cash funding and challenge experiments in dairy cows |
| Impact | Subject to confidentiality agreement |
| Start Year | 2013 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal Health Research Institute |
| Country | Taiwan, Province of China |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal Health Service |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal and Plant Quarantine Agency |
| Country | Korea, Republic of |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Harbin Veterinary Research Institute (HVRI) |
| Country | China |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Erasmus University Medical Center |
| Department | Department of Viroscience |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Experimental Zooprophylactic Institute of the Venezie |
| Country | Italy |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Fonds de la Recherche Scientifique |
| Country | Belgium |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hokkaido University |
| Department | Graduate School of Veterinary Medicine |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hokkaido University |
| Department | Research Center for Zoonosis Control |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hungarian Academy of Sciences (MTA) |
| Country | Hungary |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Konkuk University |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | National Food Chain Safety Office |
| Department | Veterinary Diagnostic Directorate |
| Country | Hungary |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | National Veterinary Institute |
| Country | Sweden |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Department | National Wildlife Research Center |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Southeast Poultry Research Laboratory |
| Country | Georgia |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | US Geological Survey |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University Libre Bruxelles (Université Libre de Bruxelles ULB) |
| Department | Spatial Epidemiology Laboratory |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Oxford |
| Department | Centre for Tropical Medicine and Global Health |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Oxford |
| Department | Department of Zoology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Wageningen |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Utrecht University |
| Department | Department of Farm Animal Health |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Major Overseas Programme in Ho Chi Minh City Vietnam |
| Country | Viet Nam |
| Sector | Charity/Non Profit |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the recent 2016/2017 outbreaks. |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | Annual Roslin Institute Open Doors Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual Roslin Institute Open Doors day was held on 14 October 2017 and was attended by 491 people. It involved 81 members of staff and students and showcased a wide range of research arising from BBSRC strategic investment, including (but not limited to), food safety, influenza, genetic improvement, DNA, imaging and the ethical treatment of animals in research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Annual Roslin Institute Open Doors Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual Roslin Institute Open Doors day was held on 14 October 2017 and was attended by 491 people. It involved 81 members of staff and students and showcased a wide range of research arising from BBSRC strategic investment, including (but not limited to), food safety, influenza, genetic improvement, DNA, imaging and the ethical treatment of animals in research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Aviagen / CP workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I presented our work on functional microbiome analysis during a one-day workshop which I set up and organised at The Roslin Institute. In attendance were employees of CP (a large Asian conglomerate) and Aviagen (one of the world's largest chicken breeding companies). The focus of the workshop was animal genetics and microbiome. |
| Year(s) Of Engagement Activity | 2010,2017 |
| Description | BBC Countryfile film related to the work of the Centre for Tropical Livestock Genetics & Health at Roslin |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Bill Gates was interviewed by BBC Countryfile on 26 January 2018 in relation to work funded by the Gates Foundation involving Roslin Institute scientists towards the genetic improvement of farmed animals in low- and middle-income countries. The programme aired on 11 February 2018 and reached an estimated audience in excess of 5 million. The interview took place on the same day as the launch of the Global Academy of Agriculture & Food Security, which was attended by the Secretary of State for the Department for International Development the Rt Hon Penny Mordaunt (see separate activity) and generated significant press interest, featuring on BBC Scotland news. Particular emphasis was placed on the work of Roslin scientists to understand the genetic make-up of African diary cattle and chickens and to understand how this relates to performance traits in order to guide breeding decisions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Careers event for S4 secondary pupils |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Opportunity for S4 pupils to interact with professionals across a range of areas including STEM. Aim was to give pupils information on careers in biological research prior to choosing final year subjects and University degrees. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| Description | International workshop on Shiga toxin-producing Escherichia coli at The Roslin Institute |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A two-day international workshop was held at The Roslin Institute on Shiga toxin-producing Escherichia coli (STEC), funded partly by this award (for travel of US collaborators) and partly by the Food Standards Agency of Scotland via a £2m award for collaborative research by a consortium led by Professor Gally. The workshop attracted leading academics working on E. coli O157 and other STEC from the US (Jim Bono, Guy Loneragan, Tom Edrington), Canada (Tim McAllister, Kim Stanford), Germany (Christian Menge), Belgium (Eric Cox), Sweden (Erik Eriksson, Lena-Mari Tamminen, Robert Soderlund) and the United Kingdom (Claire Jenkins, Tim Dallman, Dominic Mellor, Norval Strachan [Chief Scientific Advisor for FSA Scotland]). The workshop shared the latest advances in understanding of the biology of E. coli O157 and other STEC, including epidemiology, genomics, virulence, super-shedding and control strategies. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Introduction to the Research of the Roslin Institute - Royal Society of Biology Scottish Branch Annual Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Stevens provided an overview of the research of The Roslin Institute to members of the public and the Royal Society of Biology, who convened for the annual symposium of the RSB Scottish Branch on 14 October 2017 at Roslin. The event coincided with the annual Roslin 'Open Doors' day and featured BBSRC-funded research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker - Avian Genetics and Immunity Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research on Avian Genetics and Immunity (RAGI) has been established to strengthen global partnerships and links between academic researchers, students and the poultry professionals working on the genetics of avian immunity. The purpose of the symposium was to provide a forum for discussion and exchange of ideas around the single theme of exploiting available opportunities in ultimately dealing emerging and existing infectious avian diseases in poultry production systems and to safeguard food supplies and human health. The purpose of KW talk was to overview the current situation in industry for breeding for disease resistance and introduce the NARF. The overview of NARF included a review of facilities, lines available and current work being carried out using NARF avian lines. The presentation stimulated significant discussion. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://geneticsandimmunity.com/ |
| Description | Newspaper article on infection threat from unpasteurised milk products |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The article was written by myself and Dr Deborah Hoyle in response to an outbreak of E.coli O157 for which the epidemiology strongly pointed to the source being an unpasteurised soft cheese from a local producer, the outbreak resulted in the death of a three year old girl. The causative organism was not found in the company's product and the article discussed key issues around unpasteurised and minimally processed food, especially with an increase in artisan food producers, what are the risks and how should they be controlled, or not? |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.heraldscotland.com/news/health/15565022.Health_warnings_on_unpasteurised_cheese__should_b... |
| Description | Open lecture on African trypanosomes in cattle to Royal Society of Biology Scottish Branch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Liam provided an overview of his research on African trypanosomes in cattle to members of the public and the Royal Society of Biology, who convened for the annual symposium of the RSB Scottish Branch on 14 October 2017 at Roslin. The event coincided with the annual Roslin 'Open Doors' day and featured BBSRC-funded research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Press release on the development of a method to simultanoeusly analyse multiple Salmonella strains in animals |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release on work arising from this US-UK collaboration to understand the risk to food safety and animal welfare posed by Salmonella enterica serovars in cattle. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/novel-sequencing-study-salmonella-cattle |
| Description | Public lecture - Inaugural Lecture of Professor Tanja Opriessnig |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Professor Opriessnig delivered her Inaugual Lecture on 'From 'circus virus' to mostly commonly used swine vaccine on 24 April 2017, relating to her BBSRC-funded research on porcine viral diseases and strategies to detect and control them. The event was attended by children from local schools, members of the public and students of the University of Edinburgh. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public lecture entitled Confronting the Microbial Menace in Our Food'. Professor Mark Stevens |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The inaugural lecture of Professor Mark Stevens was held on 30 October 2017 on his BBSRC-funded research to identify bacterial and host factors influencing the ability of Salmonella, Campylobacter and E. coli to colonise farm animals and cause disease. It was attended by children from local schools, members of the public, students at The Roslin Institute and wider University of Edinburgh and posted online. |
| Year(s) Of Engagement Activity | 2017,2018 |
| URL | https://media.ed.ac.uk/media/Inaugural+lectureA+Confronting+the+microbial+menace+in+our+food/1_x5k5e... |
| Description | Public lecture on microbes and antimicorbial resistance by Professor David Gally, U3A event Centre for Life, Newcastle |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor David Gally delivered a public lecture at the Centre for Life, Newcastle, organised by the University of the Third Age for their Microbes and Antibiotics Day on 9 October 2017. BBSRC-funded research at the Roslin Institute featured in his presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Publish or Perish: Ethical Issues Facing Researchers. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | The workshop addressed ethical issues from study design to publication and was aimed at postgraduate students and early career researchers. This sparked debate over ethical issues in research and the questions over the practicalities of the issues involved. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Science Insights work experience for S5 school pupils |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We ran our Science Insights work experience programme for local school pupils on 24-28 July 2017. 38 S5 pupils attended, 20 of whom worked in the Roslin Institute for 2 days alongside BBSRC-supported researchers from this ISP, including our core-funded staff scientists. All 38 students also had a tour of the Langhill farm and attended a presentation and debate about the use of animals in research. Students also had the opportunity to discuss career paths and what it is like to work as a research scientist. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ed.ac.uk/roslin/working/opportunities/young-people/science-insights |
| Description | Stand at the Royal Highland Show, including the BBSRC-funded Flu Fighters exhibit. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Roslin Institute stand at the Royal Highland Show 22-25 June 2017. Approximately 25 Roslin Institute staff and students were involved. Exhibits of relevance to this ISP include the BBSRC-funded Flu Fighters exhibit, highlighting the problem of influenza and our research to combat it. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Swine Practitioner workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Practitioner meeting in France to inform them on new insights on vaccination protocols. |
| Year(s) Of Engagement Activity | 2017 |
| Description | TEDx Talk by Professor Helen Sang on 'Why do we need GM chickens?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Helen Sang delivered a Tedx Talk in Glasgow on 2 June 2017 on 'Why do we need GM chickens?'. The event was attended by approximately 1700 people and has been shared online with over 900 views. It highlighted the challenge of achieving global food security and the potential of BBSRC-funded research to improve poultry, including via genetic alteration. Examples for ongoing research using GM poultry in this programme were shared. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.youtube.com/watch?v=DUbqrh5otWs |
| Description | The Human Body activities at a BBC-sponsored Edinburgh Festival event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Researchers from The Roslin Institute joined colleagues from across the University's College of Medicine and Veterinary Medicine in the grounds of George Heriot's School in central Edinburgh to deliver family-friendly activities about 'The Human Body' on 15 August 2017. The event was part of a series of science-themed activities hosted by the BBC at the Edinburgh Festivals to support BBC Learning's 'Terrific Scientific' campaign, which aims to inspire children and young people to engage with science. Our staff and Ph.D students ran interactive activities about their research on lungs and skin, including inflating and examining real pig lungs, comparing healthy and diseased organs, and a chance for visitors to use their craft skills to make a model of their skin. Other activities at the event included anatomy face and body painting and a chance to see dissections of animal brains and hearts close-up. An estimated 1,400 family visitors were engaged, with great questions about our research and what it's like to work as a scientist. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ed.ac.uk/roslin/community-engagement/public-events/events-archive/the-human-body-bbc-at-... |
| Description | Visit by Bill Gates and the Secretary of State for the Department of International Development |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Bill Gates and the Secretary of State for the Department of International Development (DfID; Rt Hon Penny Mordaunt) visited The Roslin Institute on 26 January 2018. This involved separate sessions with the Gates Foundation and DfID to learn about the research undertaken by the Centre for Tropical Livestock Genetics & Health (CTLGH), in which the Roslin Institute is a major partner and researchers in the Institute Strategic Programmes are heavily involved. DfID announced £4m of funding for the CTLGH, adding to £10m already received from the Gates Foundation. In the presence of the Principal of the University of Edinburgh, Bill Gates and the Rt Hon Penny Mordaunt formally opened the Global Academy for Agriculture & Food Security which will provide undergraduate and postgraduate training in sustainable agriculture. The event took place in the new Campus Innovation Building (which received BBSRC strategic funding). The University of Edinburgh press office tracked the following activity related to the visit, in which many participants in the ISPs were involved: • 109 individual articles and broadcast pieces that mentioned the University with regards to the visit, with an estimated potential reach of more than 7 million people. • Of these, more than half of the coverage mentioned one of more of the Global Academy of Agriculture & Food Security, the Centre for Tropical Livestock Genetics & Health, SEBI, the Royal (Dick) School of Veterinary Studies, Roslin or the Easter Bush Campus in addition to name checking the University. • In addition to the UK, we also attracted press coverage in the USA, France, New Zealand, China, Zimbabwe, South Africa, Botswana, Taiwan and Egypt. • Across social media, we reached more than 1.4 million people with 14k+ engagements (likes, shares, retweets etc). Of these, 99.8% were positive. • The Facebook Live streaming alone reached more than 100k people. More than 18k people have watched the video. • Our news videos have garnered more than 35k views across platforms. • We tracked a spike in traffic to the Global Academy website on the day of the visit - 1405 visits (11 times the average for the previous month). |
| Year(s) Of Engagement Activity | 2018 |