Host responses underlying immunity
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
This project aims to identify host innate and adaptive responses associated with immunity following natural infection or vaccination. Novel strategies will be developed to improve antigen delivery and potentiate vaccine-mediated protection, underpinned by an Immunological Toolbox to study farm animal immunity. Emphasis will be placed on the study of pathogens in their natural farm animal hosts, supported by ongoing collaborations with academia, industry and other Institutes.
Planned Impact
unavailable
Organisations
- University of Edinburgh (Lead Research Organisation)
- International Livestock Research Institute (ILRI) (Collaboration)
- French Agency for Food, Environmental and Occupational Health & Safety (ANSES) (Collaboration)
- Polish Academy of Sciences (Collaboration)
- Keio University (Collaboration)
- CENTRE FOR ENVIRONMENT, FISHERIES AND AQUACULTURE SCIENCE (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Indian Council of Agricultural Research (Collaboration)
- Heriot-Watt University (Collaboration)
- Royal Veterinary College (RVC) (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- THE PIRBRIGHT INSTITUTE (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- AquaGen (Collaboration)
- Semmelweiss University (Collaboration)
- Wageningen University & Research (Collaboration)
- University of Stirling (Collaboration)
- Scottish Aquaculture Innovation Centre (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Norwegian University of Life Sciences (NMBU) (Collaboration)
- Adisseo (Collaboration)
- UNIVERSITY OF EXETER (Collaboration)
- GD Animal Health (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- University of Georgia (Collaboration)
- Moredun Research Institute (Collaboration)
- Complutense University of Madrid (Collaboration)
- Iowa State University (Collaboration)
- University of Padova (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- Hy-line International (Collaboration)
- Proxima Concepts Limited (Collaboration)
- University of Ghent (Collaboration)
- University of Santiago de Compostela (Collaboration)
- University of Barcelona (Collaboration)
- University of Manchester (Collaboration)
- University of Gothenburg (Collaboration)
- Babraham Institute (Collaboration)
- AB Vista (Collaboration)
- Scotland's Rural College (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Technical University of Denmark (Collaboration)
- University of Delaware (Collaboration)
- University of Missouri (Collaboration)
- Hendrix Genetics (Collaboration)
- Boehringer Ingelheim (Collaboration)
- Hellenic Centre for Marine Research (HCMR) (Collaboration)
- Xelect Ltd (Collaboration)
- MSD (United Kingdom) (Collaboration)
Publications
Akram KM
(2018)
An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.
in Mucosal immunology
Al-Hamidhi S
(2021)
A comparative study of single Theileria lestoquardi and mixed infections with Theileria ovis.
in Parasites & vectors
Alber A
(2021)
The bird's immune response to avian pathogenic Escherichia coli.
in Avian pathology : journal of the W.V.P.A
Alber A
(2019)
Dose-dependent differential resistance of inbred chicken lines to avian pathogenic Escherichia coli challenge.
in Avian pathology : journal of the W.V.P.A
Alber A
(2019)
Avian Pathogenic Escherichia coli (APEC) Strain-Dependent Immunomodulation of Respiratory Granulocytes and Mononuclear Phagocytes in CSF1R-Reporter Transgenic Chickens.
in Frontiers in immunology
Alfituri O
(2021)
Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection
in Scientific Reports
Alfituri OA
(2020)
To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host.
in Frontiers in immunology
Alfituri OA
(2021)
Corrigendum: To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host.
in Frontiers in immunology
Alfituri OA
(2019)
Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei.
in Parasite immunology
Alfituri OA
(2020)
Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection.
in Frontiers in immunology
| Title | Additional file 1 of Probiotics mediated gut microbiota diversity shifts are associated with reduction in histopathology and shedding of Lawsonia intracellularis |
| Description | Additional file 1 Number of positive pigs/total pigs per group (group mean ± SEM) for log10 L. intracellularis DNA in rectal swabs at different days post L. intracellularis challenge [24]. Different superscripts (A,B,C) indicate significantly different group means on a certain day. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_1_of_Probiotics_mediated_gut_mic... |
| Title | Additional file 1 of Probiotics mediated gut microbiota diversity shifts are associated with reduction in histopathology and shedding of Lawsonia intracellularis |
| Description | Additional file 1 Number of positive pigs/total pigs per group (group mean ± SEM) for log10 L. intracellularis DNA in rectal swabs at different days post L. intracellularis challenge [24]. Different superscripts (A,B,C) indicate significantly different group means on a certain day. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_1_of_Probiotics_mediated_gut_mic... |
| Title | Additional file 4 of Probiotics mediated gut microbiota diversity shifts are associated with reduction in histopathology and shedding of Lawsonia intracellularis |
| Description | Additional file 4. Taxonomic characteristics of ileal microbiota. OTUs clustered according to their phylogenetic relationship and colored by abundance, also called a heat-tree. The core microbes can be identified by the dark green backbone while the transient/accessory microbes compose the rest of the tree branches and change by treatment groups. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_4_of_Probiotics_mediated_gut_mic... |
| Title | Additional file 4 of Probiotics mediated gut microbiota diversity shifts are associated with reduction in histopathology and shedding of Lawsonia intracellularis |
| Description | Additional file 4. Taxonomic characteristics of ileal microbiota. OTUs clustered according to their phylogenetic relationship and colored by abundance, also called a heat-tree. The core microbes can be identified by the dark green backbone while the transient/accessory microbes compose the rest of the tree branches and change by treatment groups. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_4_of_Probiotics_mediated_gut_mic... |
| Title | MOESM1 of Development of in vitro enteroids derived from bovine small intestinal crypts |
| Description | Additional file 1. Video projection showing Z axis-projection of an enteroid whole-mount stained to detect cell nuclei. Video projection showing Z axis-projection of an enteroid whole-mount stained to detect cell nuclei. DAPI, blue. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Development_of_in_vitro_enteroids_derived_fro... |
| Title | MOESM1 of Development of in vitro enteroids derived from bovine small intestinal crypts |
| Description | Additional file 1. Video projection showing Z axis-projection of an enteroid whole-mount stained to detect cell nuclei. Video projection showing Z axis-projection of an enteroid whole-mount stained to detect cell nuclei. DAPI, blue. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Development_of_in_vitro_enteroids_derived_fro... |
| Title | MOESM1 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 1. Live/Dead staining of PCLS. PCLS (200-300 µm) prepared from PA12 SPF chickens and cultured in DMEM, DMEM/F12 or DMEM/F12/FCS. Representative images showing live (green) and dead (red) cells at day 1 (A), day 3 (B) and day 7 (C) post slice. Images were captured using a Zeiss Axiovert 200 M inverted epifluorescence microscope at ×200 magnification. Scale bars = 200 µm. Dead cells were enumerated in images from 3 to 4 independent PCLS (generated from a minimum of 2 individual birds) per time point and condition. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM1 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 1. Live/Dead staining of PCLS. PCLS (200-300 µm) prepared from PA12 SPF chickens and cultured in DMEM, DMEM/F12 or DMEM/F12/FCS. Representative images showing live (green) and dead (red) cells at day 1 (A), day 3 (B) and day 7 (C) post slice. Images were captured using a Zeiss Axiovert 200 M inverted epifluorescence microscope at ×200 magnification. Scale bars = 200 µm. Dead cells were enumerated in images from 3 to 4 independent PCLS (generated from a minimum of 2 individual birds) per time point and condition. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM2 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 2. Limited effect of ambient temperature on PCLS viability. PCLS (500 µm) were prepared from CSF1R-eGFP transgenic chickens and viability assessed by AlamarBlue assay over 40 days of culture at either 41 °C or 37 °C. Every 24 h the PCLS were incubated for 1 h with AlamarBlue reagent, the supernatants harvested and the fluorescence assessed in the supernatant relative to media incubated with AlamarBlue in the absence of PCLS. n = 6-14 slices prepared from 2 individual birds. Data are represented as the mean ± SD. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM2_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM2 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 2. Limited effect of ambient temperature on PCLS viability. PCLS (500 µm) were prepared from CSF1R-eGFP transgenic chickens and viability assessed by AlamarBlue assay over 40 days of culture at either 41 °C or 37 °C. Every 24 h the PCLS were incubated for 1 h with AlamarBlue reagent, the supernatants harvested and the fluorescence assessed in the supernatant relative to media incubated with AlamarBlue in the absence of PCLS. n = 6-14 slices prepared from 2 individual birds. Data are represented as the mean ± SD. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM2_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM3 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 3. Mononuclear phagocytic cell motility in PCLS at 21 days post slice. eGFP-expressing mononuclear phagocytic cells (green) in PCLS (500 µm) generated from CSF1R-eGFP transgenic chickens were examined by time-lapse imaging using a Zeiss live cell observer with a 20× objective lens. The PCLS was imaging every 30 s for 1 h. The image was cropped to a region of interest demonstrating the motility of CSF1R-eGFP+ cells (green). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM3_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM3 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 3. Mononuclear phagocytic cell motility in PCLS at 21 days post slice. eGFP-expressing mononuclear phagocytic cells (green) in PCLS (500 µm) generated from CSF1R-eGFP transgenic chickens were examined by time-lapse imaging using a Zeiss live cell observer with a 20× objective lens. The PCLS was imaging every 30 s for 1 h. The image was cropped to a region of interest demonstrating the motility of CSF1R-eGFP+ cells (green). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM3_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM4 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 4. Additional controls for ß-tubulin, NP and NS1 immunofluorescent staining of PCLS. Isotype controls for ß-tubulin as shown in Figure 3A. PCLS (200-300 µm) prepared from PA12 SPF chickens were cultured in DMEM/F12/FCS (A, panel i), DMEM/F12 (A, panel ii) or DMEM (A, panel iii), fixed and incubated with purified mouse IgG2a (Thermo Fischer Scientific, USA), the corresponding isotype control for the anti-ß-tubulin antibody, followed by staining with goat anti-mouse IgG (H + L) Alexa Fluor 488 secondary antibody. Images were captured using a Leica TCS P8 confocal microscope at ×200 magnification. Scale bars = 75 µm. Images are representative of 3 independent PCLS per condition. Corresponding controls for PCLS (500 µm or 200-300 µm) infected with LPAI virus strains H7N1 or H1N1, respectively, show in Figure 7B. Immunofluorescent staining is shown for isotype control mouse IgG2a with secondary goat anti-mouse Ig FITC (B, panel i) and goat anti-mouse IgG-FITC secondary antibody alone (B, panel ii), which are the corresponding controls for the viral nucleoprotein (NP) staining of H7N1-infected PCLS. Immunofluorescent staining is shown for PCLS incubated with non-immunized rabbit serum (B, panel iii), the corresponding control for NS1 staining of H1N1-infected PCLS, followed by staining with goat anti-rabbit IgG (H + L) Alexa Fluor 488 secondary antibody. Images were captured using confocal microscopy at ×400 magnification. Scale bars = 10 µm (B, panels i and ii) and 25 µm (B, panel iii). All Images are representative of a minimum of 3 independent PCLS per condition, generated from a minimum of 2 individual birds. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM4_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM4 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 4. Additional controls for ß-tubulin, NP and NS1 immunofluorescent staining of PCLS. Isotype controls for ß-tubulin as shown in Figure 3A. PCLS (200-300 µm) prepared from PA12 SPF chickens were cultured in DMEM/F12/FCS (A, panel i), DMEM/F12 (A, panel ii) or DMEM (A, panel iii), fixed and incubated with purified mouse IgG2a (Thermo Fischer Scientific, USA), the corresponding isotype control for the anti-ß-tubulin antibody, followed by staining with goat anti-mouse IgG (H + L) Alexa Fluor 488 secondary antibody. Images were captured using a Leica TCS P8 confocal microscope at ×200 magnification. Scale bars = 75 µm. Images are representative of 3 independent PCLS per condition. Corresponding controls for PCLS (500 µm or 200-300 µm) infected with LPAI virus strains H7N1 or H1N1, respectively, show in Figure 7B. Immunofluorescent staining is shown for isotype control mouse IgG2a with secondary goat anti-mouse Ig FITC (B, panel i) and goat anti-mouse IgG-FITC secondary antibody alone (B, panel ii), which are the corresponding controls for the viral nucleoprotein (NP) staining of H7N1-infected PCLS. Immunofluorescent staining is shown for PCLS incubated with non-immunized rabbit serum (B, panel iii), the corresponding control for NS1 staining of H1N1-infected PCLS, followed by staining with goat anti-rabbit IgG (H + L) Alexa Fluor 488 secondary antibody. Images were captured using confocal microscopy at ×400 magnification. Scale bars = 10 µm (B, panels i and ii) and 25 µm (B, panel iii). All Images are representative of a minimum of 3 independent PCLS per condition, generated from a minimum of 2 individual birds. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM4_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM5 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 5. Additional controls for Actin, von Willebrand Factor, MCRL1-B and CD45 immunofluorescent staining of PCLS. Staining controls for Actin (A), von Willebrand Factor (B), MCRL1-B (C) and CD45 (D) immunofluorescent staining of PCLS (200-300 µm) as shown in Figure 4. PCLS prepared from SPF PA12 chickens 1 day post slice were fixed and incubated with: unlabelled phalloidin (A) (Abcam, UK), the corresponding control for the Rhodamine Phalloidin cytoskeleton staining; Purified rabbit IgG (Sigma-Aldrich, UK), the corresponding control for the von Willebrand Factor endothelial cells staining (B), followed by staining with goat anti-rabbit IgG (H + L) Alexa Fluor Plus 594 secondary antibody (Thermo Fisher Scientific, USA); Purified mouse IgG1 (Bio-Rad, UK), the corresponding control for the MCRL1-B+ monocytes/macrophages staining (C), followed by staining with goat anti-mouse IgG (H + L) Alexa Fluor 488 secondary antibody (Thermo Fisher Scientific, USA); and Purified mouse IgG2a (Bio-Rad, UK), the corresponding control for the CD45+ leukocytes staining (D), followed by staining with goat anti-mouse IgG (H + L) Alexa Fluor 488 secondary antibody (Thermo Fisher Scientific, USA). Images were captured using a Leica TCS P8 confocal microscope at ×200 magnification. Scale bars = 25 µm. All Images are representative of a minimum of 3 independent PCLS per condition, generated from a minimum of 2 individual birds. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM5_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM5 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 5. Additional controls for Actin, von Willebrand Factor, MCRL1-B and CD45 immunofluorescent staining of PCLS. Staining controls for Actin (A), von Willebrand Factor (B), MCRL1-B (C) and CD45 (D) immunofluorescent staining of PCLS (200-300 µm) as shown in Figure 4. PCLS prepared from SPF PA12 chickens 1 day post slice were fixed and incubated with: unlabelled phalloidin (A) (Abcam, UK), the corresponding control for the Rhodamine Phalloidin cytoskeleton staining; Purified rabbit IgG (Sigma-Aldrich, UK), the corresponding control for the von Willebrand Factor endothelial cells staining (B), followed by staining with goat anti-rabbit IgG (H + L) Alexa Fluor Plus 594 secondary antibody (Thermo Fisher Scientific, USA); Purified mouse IgG1 (Bio-Rad, UK), the corresponding control for the MCRL1-B+ monocytes/macrophages staining (C), followed by staining with goat anti-mouse IgG (H + L) Alexa Fluor 488 secondary antibody (Thermo Fisher Scientific, USA); and Purified mouse IgG2a (Bio-Rad, UK), the corresponding control for the CD45+ leukocytes staining (D), followed by staining with goat anti-mouse IgG (H + L) Alexa Fluor 488 secondary antibody (Thermo Fisher Scientific, USA). Images were captured using a Leica TCS P8 confocal microscope at ×200 magnification. Scale bars = 25 µm. All Images are representative of a minimum of 3 independent PCLS per condition, generated from a minimum of 2 individual birds. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM5_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM6 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 6. Mononuclear phagocytic cell motility within the PCLS at 3 days post slice. PCLS (500 µm) prepared from CSF1R-eGFP transgenic chickens were incubated with fluorescent 1 µm latex beads (red) at 3 days post slice. Cellular motility and interactions were captured by time-lapse imaging using a Zeiss Live cell observer with a ×10 objective lens. The PCLS was imaged every 3 min for 18 h. The image was cropped to a region of interest demonstrating the motility and dynamic interactions of CSF1R-eGFP+ cells (green). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM6_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM6 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 6. Mononuclear phagocytic cell motility within the PCLS at 3 days post slice. PCLS (500 µm) prepared from CSF1R-eGFP transgenic chickens were incubated with fluorescent 1 µm latex beads (red) at 3 days post slice. Cellular motility and interactions were captured by time-lapse imaging using a Zeiss Live cell observer with a ×10 objective lens. The PCLS was imaged every 3 min for 18 h. The image was cropped to a region of interest demonstrating the motility and dynamic interactions of CSF1R-eGFP+ cells (green). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM6_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM7 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 7. Dynamic interaction of mononuclear phagocytes with fluorescent latex beads. PCLS (500 µm) prepared from CSF1R-eGFP transgenic chickens were incubated with 1 µm fluorescent latex beads at 3 days post slice, and were examined by time-lapse imaging using a Zeiss Live cell observer with a ×10 objective lens. The PCLS was imaged every 3 min for 18 h. The image was cropped to a region of interest demonstrating that CSF1R-eGFP+ cells (green) were phagocytosing latex beads (red). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM7_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM7 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 7. Dynamic interaction of mononuclear phagocytes with fluorescent latex beads. PCLS (500 µm) prepared from CSF1R-eGFP transgenic chickens were incubated with 1 µm fluorescent latex beads at 3 days post slice, and were examined by time-lapse imaging using a Zeiss Live cell observer with a ×10 objective lens. The PCLS was imaged every 3 min for 18 h. The image was cropped to a region of interest demonstrating that CSF1R-eGFP+ cells (green) were phagocytosing latex beads (red). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM7_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM8 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 8. Dynamic interactions of mononuclear phagocytes with APEC-eGFP. PCLS (500 µm) prepared from CSF1R-mApple transgenic chickens were imaged at 3 days post slice using a Zeiss Live cell observer with a ×10 objective lens. The PCLS was imaged every 1 min for 1 h. The image was cropped to a region of interest demonstrating that CSF1R-mApple+ cells (red) were interacting with APEC-eGFP (green). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM8_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Title | MOESM8 of Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung |
| Description | Additional file 8. Dynamic interactions of mononuclear phagocytes with APEC-eGFP. PCLS (500 µm) prepared from CSF1R-mApple transgenic chickens were imaged at 3 days post slice using a Zeiss Live cell observer with a ×10 objective lens. The PCLS was imaged every 1 min for 1 h. The image was cropped to a region of interest demonstrating that CSF1R-mApple+ cells (red) were interacting with APEC-eGFP (green). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://springernature.figshare.com/articles/MOESM8_of_Precision_cut_lung_slices_a_novel_versatile_t... |
| Description | Mechanisms of innate immunity and clearance of primary infection Immune priming in avian species differs greatly from mammals and a need exists to dissect antigen presentation to more effectively induce and enhance immunity. To this end, we have used transgenic chickens expressing fluorescent protein under the control of the CSF1R promoter to identify functionally discrete populations of myeloid cells; study infections in vivo, including avian pathogenic E. coli in the lung and Salmonella in the bursa and intestines; and to characterise antigen-sampling epithelial cells in avian follicle-associated epithelium that we propose to be the functional equivalent of mammalian M cells. We have also produced a gene edited XCR1 knockout line of chickens which will enable the role of conventional dendritic cells in resistance to specific pathogens to be determined. We have linked natural variation in the dendritic cell (DC) marker FLT3 in our inbred chicken lines to differences in their resistance to infection, priming uplift funding to examine the role of FLT3 via genome editing. The long pentraxin PTX3 was found to be a key acute phase protein in the response of chickens to E. coli infection, and may prove useful as a blood marker of inflammatory status. Linked to ISP1, we have generated transcript and epigenomic atlases (RNA-Seq, ATAC-Seq & methylation data) for seven bovine immune cell subsets (CD4+, CD8+ & gamma delta?TCR+ T cells, natural killer (NK) cells, B cells, monocytes & neutrophils) from European and African cattle breeds to underpin research on resistance to Theileria and other diseases. Single cell RNA-seq was used to show that CD16- monocytes are key regulators of the transcriptional response to Toxoplasma gondii in human macrophages and this can be compared with the response of bovine macrophages to T. gondii infection. Single cell liver responses at a transcriptional level have now been investigated in response to Aeromonas infection in Atlantic salmon. In relation to prion pathogenesis, we observed that CD44 is a marker of reactive astrocytes associated with early stages of disease and found that astrocyte activation was correlated with reduced survival of mice co-infected with a gut helminth. Prion disease after intravenous inoculation was found to be unaffected by temporary absence of marginal zone B cells. Mechanisms of vaccine-induced protective immunity. In collaboration with Pirbright, we have found that recombinant infectious bronchitis viruses (IBV) expressing chimeric spike glycoproteins induce partial protective immunity despite limited replication, and identified IBV antibody epitopes that are prone to mutate under immune pressure. This led to a bioinformatics pipeline to predict biologically constrained epitopes of IBV and IAV for inclusion in vaccines. Work on novel bTB and Johne's Disease vaccines revealed a hitherto unappreciated role for NK cells in induction of bovine immune responses through interactions of DCs. We have developed assays for interactions between antigen-presenting cells (APCs) and populations of unconventional T cells (gamma delta?TCR+ T-cells or NKp46+CD3+ cells), or NK cells in the context of M. bovis infection or BCG vaccination. Our lymphatic cannulation model has allowed identification of phenotypically distinct subpopulations of NK cells draining the skin, and the isolation of single cells for transcriptomic analysis pre- and post-vaccination with novel adjuvants and antigens to identify correlates of protection. We have achieved a very high success rate with calf cannulations with lymph being collected from 17/20 calves cannulated since 01/20. Previous reported success rate was ~50%, and with refinements to the technique this is now above 80%. This significantly increases our capability to examine the responses of cells draining vaccine sites. We have generated single cell transcriptomic data alongside functional analyses of cells present in skin draining lymph in both the steady state and post-vaccination. This works links to identification of biomarkers for cattle infected with bTB as well as immunised animals and will facilitate studies to identify new adjuvants or targets for vaccine delivery. We have also characterised novel mycobacterial lipopeptides as target epitopes for T cells and, with uplift funding with the University of Oxford and Pirbright, are examining the role of mucosa-associated invariant T cells in bacterial infections in cattle. ISP-funded staff also supported the evaluation of novel vaccines for pigs, including a live genogroup 1b vaccine for control of porcine epidemic diarrhoea, and M2e-based vaccines for swine influenza. We have demonstrated protection with a virus-vectored multivalent vaccine against PRRSV, PCV type 2 and swine influenza. Roslin Technologies Ltd have licenced our technology around an E. coli O157 cattle vaccine developed by an Edinburgh consortium. This has led to the manufacture of the vaccine in the USA and testing of efficacy on a commercial feedlot in collaboration with ARS-USDA. Novel strategies to potentiate immunity. Toward improved adjuvants, we demonstrated that recombinant FLT3 ligand has the potential to target fused antigens to chicken DCs and, with ISP1, we are analysing the transcriptome of avian and bovine M cells with a view to predicting surface proteins that can be used for antigen targeting. We partnered with industry to evaluate novel adjuvant formulations, including cobalt nanoparticles for M. bovis Ag85 in cattle (Benchmark) and oil-based formulations in chickens for IAV and recombinant proteins of Eimeria (Proxima Concepts). With scientists at the University of Manchester, we found that antigen-presenting type 3 innate lymphoid cells regulate T cell-dependent IgA responses to gut bacteria. Work in the programme has shown that microbial stimulation can overturn age-related decline in M-cells that are key to fighting infection. Specifically, a related decline in M-cells can be reversed by exposure of the epithelium in older animals/humans to flagellin or particular bacteria-related probiotics. We also showed that B cells can acquire antigens sampled from the gut lumen by M-cells in the subepithelial dome of Peyer's patches independently of DCs. Targeting this pathway, and using microbiota to enhance M-cell function, may offer novel strategies to potentiate mucosal immunity. Modelling interventions. With uplift funding from USDA and in collaboration with the USDA ADOL poultry research facilities, we conducted a study involving large scale Marek's disease virus transmission experiments in chicken to demonstrate that that even partial vaccination with a leaky vaccine can have unforeseen positive consequences in reducing pathogen spread and disease prevalence also in unvaccinated infected animals. We have also developed a novel mathematical modelling framework that allows assessment of the effectiveness of vaccines for preventing, mitigating or eliminating infectious diseases in livestock. Applying the framework to PRRS in pigs, we found that even imperfect vaccines can prevent, eliminate or largely reduce the spread of the PRRS virus in pig populations. A wiki-website containing a user-friendly interactive modelling app was developed to illustrate how different types of vaccine and vaccination strategies may together influence disease spread. Complementary to the theoretical models, and with uplift funding from the EU H2020 project Saphir, we led the design and analysis of a PRRS transmission experiments to assess the effectiveness of a novel PRRS vaccine candidate on PRRS virus transmission. The study confirmed the theoretical model results that even a vaccine that does not block virus transmission, or only elicits serological response on a proportion of vaccinated animals, can substantially reduce the overall transmission potential of the virus, represented by the reproductive ratio R. The mathematical modelling and experimental results combined provide practical implications for the development and evaluation of vaccines and vaccination strategies in heterogeneous populations. Tools and resources for veterinary vaccinology. We have a joint 'Toolbox' initiative with Pirbright to address the paucity of reagents for immunology in farmed animals. The work links to ISP1 (Blueprints for healthy animals) where editing and transgenic technologies are used to study the location and function of immune cells in situ, as with fluorescent reporters for myeloid lineages and null mutants (e.g. in FLT3 and IL-10, and an iCaspase9-based system for inducible ablation of specific cells under development). At Roslin, we have produced monoclonal antibodies (mAbs) to detect macrophage markers in pigs (ADGRE1 and CSF1R) and chickens (CSF1R). We also have produced recombinant avian and porcine CSF1, and avian FLT3 (which binds to conventional dendritic cells; cDCs), and are exploring the ability of these to potentiate immunity to fused antigens via uplift funding and an Impact Accelerator award. We also produced a mAb to bovine CD107a to assess T cell function and generated recombinant bovine CX3CL1 to detect expression of CX3CR1 across ruminant species. The Roslin arm of the Toolbox is currently producing a mAb for avian IL-10 in support of ongoing research that has implicated IL-10 in resistance to Eimeria; generating reagents to bovine CD138 to dissect B-cell function; validating antibodies to the bovine NK receptor CD244; generating mAbs to CD161 enabling studies of invariant T cell subsets in pigs and cattle; producing molecular probes to enable identification of porcine Tfh cells; and generating recombinant avian RANKL and OPG to enable in vitro differentiation of M cells, alongside mAbs to M cell surface proteins toward the targeting of antigens for mucosal vaccination. mAbs arising from the Toolbox are commercialised by Bio-Rad. In collaboration with Pirbright, we launched a website and database of reagents to act as a repository of information on the location, supply and applicability of veterinary immune reagents and associated methods. In addition to recombinant proteins, mAbs and immunological assays, we have devised and validated a high-throughput MiSeq-based strategy for comprehensive genotyping of bovine MHCI and MHCII, enabling associations with disease resistance or vaccine responses to be dissected. Our cattle herd at Langhill has now been fully MHC typed, providing a valuable resource to examine innate and adaptive responses. Our collaborative research has used MHC peptide elution to define the peptide binding motifs of a variety of bovine MHCI molecules, which we are extrapolating to MHCII. Sequence-based MHCI typing has been extended to sheep, goats, water buffalo and pig, and via CTLGH we are analysing MHC diversity to understand why responses to pathogens and vaccines differ between individuals, breeds and geographical locations. ISP-funded staff are also supporting the development of sequenced-based assays for T cell receptor repertoires. ISP funding, with uplift from the Gates Foundation, has also generated a pipeline for isolating and characterising bovine antigen-specific B cells. Of particular interest are bovine long-CDR3 domain antibodies that are hypothesised to penetrate surface glycoprotein coats on parasite surfaces that sterically hinder access of conventional antibodies to underlying invariant epitopes. Using this pipeline, we have isolated and cultured 4,500 single antigen-specific B cells and obtained paired heavy and light chain sequences toward vaccines for African trypanosomiasis. SARS-CoV2 related research. |
| Exploitation Route | A separate knowledge exchange and communication report is produced for the Roslin ISPs. This theme of the control of infectious diseases of livestock programme is focused on the immune response in farmed animal species. The majority of the research in this space works towards both improved or new diagnostics of infections by using the immune response or working with approaches, such as vaccines, to prime the animal to resist infection when it does see the pathogen. We have made significant progress in these areas for infections that impact the welfare and productivity of farmed poultry, pigs, cattle and fish. We have numerous commercial partners for this research and these partnerships are an important route to 'use by others'. The international veterinary vaccinology network and knowledge exchange with our Centre for Tropical Livestock Genetics & Health (CTLGH) targets impact in low- and middle-income countries (LMICs). We continue to develop new immunological reagents through our 'toolbox' and these are made generally available for use by others in academic and industrial settings. We are developing animal models and expertise in vulnerable skills as well as culture methods to reduce animal use and provide better models of infection and immune responses. |
| Sectors | Agriculture Food and Drink Education Pharmaceuticals and Medical Biotechnology |
| URL | https://www.ed.ac.uk/roslin/research/isp |
| Description | The proposed outputs of this theme of the programme are: correlates of natural immunity and vaccine-mediated protection for vaccine design, potency tests and 3R assays; novel immuno-modulatory substances and delivery systems to potentiate beneficial responses; toolboxes, animal models and expertise for application in veterinary vaccinology; mathematical models of the impact of natural or vaccine-induced immunity on disease prevalence and transmission of zoonoses at population scale; training in vulnerable skills, especially in vivo research in relevant hosts. Specific examples of this research include; (1) an association Proxima Concepts/Vaxcine UK to target M-cells during vaccination of poultry; (2) an agreement with Roslin Technologies to trial a trivalent vaccine to restrict E. coli O157 excretion form cattle on a feedlot; (3) Partnership with Neiker (Spain) in development of bTB and MAP vaccines; (4) Partnering with Benchmark to test cobalt nanoparticles as an adjuvant with an bTb subunit vaccine that is in development. The other major area is the generation of livestock species immunological reagents. Under the toolbox section we continue to generate specific reagents, mainly monoclonals, to livestock species surface markers that have value in the commercial and academic sectors. Several PIs Connelley and Hope have contributed to development of the BBSRC Veterinary Vaccinology Strategy for 2021-2026 and advise the BactiVac Network with 1,192 members in 75 countries aiming to develop bacterial vaccines. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink,Education,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | Academy of Medical Sciences's "Preparing for a challenging winter 2020/21" report |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.gov.uk/government/publications/covid-19-preparing-for-a-challenging-winter-202021-7-july... |
| Description | Member of Defra's Science Advisory Council |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | As a member of Defra's Science Advisory Council, I provide comments on a wide variety of Defra science-related policies and draw upon both my personal research experience, but also the broader research community at the Roslin Institute |
| URL | https://www.gov.uk/government/organisations/science-advisory-council/about/our-governance#members |
| Description | Member of SAC-ED HPAI |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | A UK underpinning platform to study immunology and immunopathology of COVID-19: The UK Coronavirus Immunology Consortium (UK-CIC) |
| Amount | £633,154 (GBP) |
| Funding ID | 1257927 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 08/2021 |
| Description | A data-driven single cell sequencing approach to support innovation in Atlantic salmon aquaculture |
| Amount | £49,944 (GBP) |
| Organisation | Government of Scotland |
| Department | Scottish Funding Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 07/2021 |
| Description | AquaLeap: Innovation in Genetics and Breeding to Advance UK Aquaculture Production |
| Amount | £237,484 (GBP) |
| Funding ID | BB/S004181/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2022 |
| Description | BBSRC - BBR call 2017, GCRF highlight call |
| Amount | £75,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 06/2018 |
| Description | BBSRC Responsive Mode |
| Amount | £644,177 (GBP) |
| Funding ID | BB/R008272/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | BBSRC-iCASE-Chicken Intestinal Organoids: A Novel In Vitro System To Study Mucosal Vaccine Targeting |
| Amount | £95,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 09/2021 |
| Description | Bioinformatics and Biological Resources Fund - Andy Law - Facilitating application of NGS to analysis of livestock T-cell receptor repertoires |
| Amount | £71,870 (GBP) |
| Funding ID | BB/P024629/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 06/2018 |
| Description | COOLFISH: Improving Atlantic salmon health and welfare by metabolic programming |
| Amount | kr 12,491,000 (NOK) |
| Funding ID | 325571 |
| Organisation | Research Council of Norway |
| Sector | Public |
| Country | Norway |
| Start | 01/2022 |
| End | 06/2026 |
| Description | Center for Tropical Livestock Health and Genetics |
| Amount | £15,000,000 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 02/2017 |
| End | 03/2020 |
| Description | Chicken enteroids: exploring their potential as mucosal immunological model |
| Amount | £13,275 (GBP) |
| Funding ID | FTMA Panel- Email-10/12/19 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 03/2020 |
| Description | Combined influence of imperfect vaccines, host genetics, and non-genetic drivers on virus transmission and virulence evolution |
| Amount | £1,837,983 (GBP) |
| Funding ID | BB/V017411/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 12/2023 |
| Description | Defining early entry mechanisms of Mycobacterium avium paratuberculosis into the host |
| Amount | £552,222 (GBP) |
| Funding ID | BB/T007354/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2022 |
| Description | Defining mechani1sms of CD8+ T-cell mediated immunity - using an integrated longitudinal model to achieve an elusive goal. |
| Amount | £532,434 (GBP) |
| Funding ID | BB/S017151/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 07/2024 |
| Description | Dendritic cell targeting to enhance vaccination efficacy in immunologically naïve chicks |
| Amount | £9,544 (GBP) |
| Funding ID | BBSRC IAA PIII-016 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 08/2019 |
| Description | Development of a PCR assay for the direct detection of Mycobacterium bovis DNA to improve the diagnosis of Bovine Tuberculosis |
| Amount | £4,567 (GBP) |
| Funding ID | Roslin2352 |
| Organisation | MV Diagnostics Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 05/2019 |
| Description | Development of a cost-effective protocol for MHC genotyping in red deer |
| Amount | £9,990 (GBP) |
| Funding ID | RES2019SPE |
| Organisation | British Deer Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2021 |
| Description | Development of an alternative live vaccine against Theileria parva using cultured cells |
| Amount | £126,629 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 02/2019 |
| End | 01/2020 |
| Description | Development of bovine abomasal enteroids as a tool to study host-pathogen interactions in Ostertagia ostertagi infections |
| Amount | £11,525 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2021 |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £312,917 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 05/2022 |
| Description | Edinburgh Clinical Academic Track - Consortium funding - Kenny Baillie for RI - ECAT-Plus: The role of CD97 in the host response to infection with influenza A virus |
| Amount | £268,182 (GBP) |
| Funding ID | 203913/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 07/2020 |
| Description | Effect of natural microbiota treatment on the chicken microbiota, immune system and induction of vaccine responses |
| Amount | £4,971 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2020 |
| Description | Exploiting ultra-long bovine antibodies to target African Animal Trypanosomiasis |
| Amount | £57,576 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2018 |
| End | 12/2019 |
| Description | FTMA 3: The role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken |
| Amount | £18,106 (GBP) |
| Funding ID | 11824433 BB/W510944/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2021 |
| End | 03/2022 |
| Description | FTMA 3: Transciptomic investigations into two important infectious diseasesof cattle: towards a better understanding of host responses to infection and vaccination |
| Amount | £5,000 (GBP) |
| Funding ID | 11891868 BB/W510944/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 03/2022 |
| Description | Flexible Talent Mobility Account - 4 |
| Amount | £75,000 (GBP) |
| Funding ID | BB/X017613/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 03/2023 |
| Description | GCRF Global Challenges Research Fund - Tim Connelley - International Veterinary Vaccinology Network |
| Amount | £2,113,339 (GBP) |
| Funding ID | MR/R005958/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 06/2021 |
| Description | GCRF Impact Accelerator |
| Amount | £300,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 03/2018 |
| Description | GCRF Impact Accelerator |
| Amount | £300,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 03/2018 |
| Description | General Scheme - Lonneke Vervelde - Chicken Intestinal Organoids: A Novel In Vitro System To Study Mucosal Vaccine Targeting |
| Amount | £24,000 (GBP) |
| Funding ID | WT 5906748 |
| Organisation | Intervet International B.V. |
| Sector | Private |
| Country | Netherlands |
| Start | 08/2017 |
| End | 08/2021 |
| Description | General Scheme - Tanja Oppriesnig - Characterizing and contrasting the humoral responses against PCV2a and PCV2d |
| Amount | £20,652 (GBP) |
| Funding ID | 338EMD R40759 |
| Organisation | Boehringer Ingelheim |
| Sector | Private |
| Country | Germany |
| Start | 01/2017 |
| End | 06/2018 |
| Description | GutMIVir - Understanding the contribution of the gut microbiota to mucosal immunity and antiviral defences in the chicken |
| Amount | £89,508 (GBP) |
| Funding ID | C12025 |
| Organisation | Adisseo |
| Sector | Private |
| Country | France |
| Start | 11/2022 |
| End | 10/2025 |
| Description | H2020 |
| Amount | € 5,500,000 (EUR) |
| Funding ID | DELTA-FLU |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 04/2017 |
| End | 04/2022 |
| Description | H2020-SFS-2018-2 "AQUA-FAANG - Advancing European Aquaculture by Genome Functional Annotation" |
| Amount | € 6,000,000 (EUR) |
| Funding ID | 817923 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 04/2019 |
| End | 04/2022 |
| Description | Hatching and raising IL10-Exon1 knockout chickens in the conventional (non-SPF) Greenwood Facility |
| Amount | £16,431 (GBP) |
| Organisation | Cobb Vantress |
| Sector | Private |
| Country | United States |
| Start | 11/2022 |
| End | 11/2023 |
| Description | High throughput qPCR analysis Cobb samples |
| Amount | £42,546 (GBP) |
| Organisation | Cobb Vantress |
| Sector | Private |
| Country | United States |
| Start | 03/2021 |
| End | 05/2021 |
| Description | High-Resolution Ion Mobility enabled DART/LC-MS for metabolomics applications |
| Amount | £715,056 (GBP) |
| Funding ID | BB/X019608/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2023 |
| End | 07/2024 |
| Description | Horizon 2020 - Research Infrastructures - Mark Stevens - REVeterinary biocontained facility network for excellence in animal infectiology research and experimentation |
| Amount | £282,513 (GBP) |
| Funding ID | 731014 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2017 |
| End | 02/2022 |
| Description | Horizon H2020 - Fast Track to Innovation - Lonneke Vervelde - Dynamics of avian influenza in a changing world |
| Amount | £403,373 (GBP) |
| Funding ID | 727922 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2017 |
| End | 05/2022 |
| Description | Horserace betting levy board research call 2017 |
| Amount | £5,800 (GBP) |
| Organisation | Horserace Betting Levy Board |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 02/2019 |
| Description | Identification of interferon stimulated genes that control Toxoplasma in pig macrophages |
| Amount | £588,626 (GBP) |
| Funding ID | BB/W014807/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 06/2025 |
| Description | Identification of interferon stimulated genes that restrict cross-species transmission of influenza A virus. |
| Amount | £614,702 (GBP) |
| Funding ID | BB/S00114X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 09/2023 |
| Description | Immune cell dynamics predictive of vaccine protection in Atlantic salmon |
| Amount | £500,839 (GBP) |
| Funding ID | BB/W005859/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 03/2025 |
| Description | Immune cell dynamics predictive of vaccine protection in Atlantic salmon |
| Amount | £626,049 (GBP) |
| Funding ID | BB/W005859/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 04/2025 |
| Description | Impact accelerator award |
| Amount | £30,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 02/2018 |
| Description | Inflammation in COVID-19 - Exploration of Critical Aspects of Pathogenesis - The ICECAP COVID-19 post-mortem study |
| Amount | £19,938 (GBP) |
| Funding ID | CVG-1722-2020 |
| Organisation | Medical Research Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 11/2020 |
| Description | Interferon-stimulated genes as resilience factors for PRRSV infection |
| Amount | £642,924 (GBP) |
| Funding ID | BB/T015179/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 11/2024 |
| Description | International Travel Award Scheme |
| Amount | £2,500 (GBP) |
| Funding ID | BB/R012377/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| Description | International Veterinary Vaccinology Network |
| Amount | £600,000 (GBP) |
| Funding ID | MC_PC_17219 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | Investigation of proven vaccine breakthrough by SARS-CoV-2 variants in established UK healthcare worker cohorts: SIREN consortium & PITCH Plus Pathway |
| Amount | £1,585,765 (GBP) |
| Funding ID | MR/W02067X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 08/2023 |
| Description | Japan Partnering Award: Defining the factors that regulate M cell-development in the intestines of livestock |
| Amount | £42,125 (GBP) |
| Funding ID | BB/S019294/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 06/2023 |
| Description | Large memory HPC infrastructure to underpin world-class biological research |
| Amount | £600,000 (GBP) |
| Funding ID | BB/S019367/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2020 |
| Description | MRC IAA Engagement Award: Support industrial engagement activity scoping for co-development opportunities on a multi-biomarker bovine TB diagnostic |
| Amount | £1,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 03/2023 |
| Description | National Institute of Food and Agriculture Default Scheme - Tim Connelley - Role of the T cell receptor in interacting with WC1 for bovine gamma delta T cell activation |
| Amount | £75,612 (GBP) |
| Funding ID | Subaward no 17 009922 A 00 |
| Organisation | U.S. Department of Agriculture USDA |
| Department | National Institute for Food and Agriculture |
| Sector | Public |
| Country | United States |
| Start | 05/2017 |
| End | 05/2020 |
| Description | Newton fund - Christine Tait-Burkard - A strategic approach to identifying and combating porcine reproductive and respiratory syndrome virus outbreaks and other porcine viral diseases |
| Amount | £983,771 (GBP) |
| Funding ID | BB/R013187/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | Novel approaches to the development of veterinary vaccines to control bacterial infections |
| Amount | £10,081 (GBP) |
| Funding ID | BB/X018547/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 12/2023 |
| Description | One Health Models of Disease: Science, Ethics and Society |
| Amount | £5,328,962 (GBP) |
| Funding ID | 218471/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2028 |
| Description | One Health Models of Disease: Science, Ethics and Society |
| Amount | £5,328,962 (GBP) |
| Funding ID | 218471/Z/19/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2028 |
| Description | Outbreak Data Analysis Platform |
| Amount | £1,198,705 (GBP) |
| Funding ID | HDR UK 2021.0125 |
| Organisation | Health Data Research UK |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2022 |
| Description | Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes (PHOSP-COVID) |
| Amount | £1,101,992 (GBP) |
| Funding ID | MR/V027859/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2020 |
| End | 08/2022 |
| Description | Regulatory approval and antigen production towards testing an experimental vaccine in a feedlot trial in the USA to limit E. coli O157 excretion from cattle. |
| Amount | £20,000 (GBP) |
| Funding ID | IAA PIII043 subaward of R45393 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 09/2020 |
| Description | Research Grant - Christine Tait-Burkard - Nanobodies as antiviral PRRSV agents |
| Amount | £59,802 (GBP) |
| Funding ID | Roslin Contracts Ref 2191 |
| Organisation | Eco Animal Health Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | Research Grant - Lonneke Vervelde - Development of in vitro chicken enterocyte and organoid cultures |
| Amount | £136,852 (GBP) |
| Funding ID | WT 6571120 |
| Organisation | Novozymes |
| Sector | Public |
| Country | Denmark |
| Start | 12/2018 |
| End | 11/2019 |
| Description | Research Grant - Lonneke Vervelde - Towards edible vaccines for chickens |
| Amount | £99,656 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 12/2019 |
| Description | Responsive Mode - Adam Balic - Exploitation of new technologies to advance understanding of avian dendritic cell biology |
| Amount | £589,932 (GBP) |
| Funding ID | BB/R003653/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2020 |
| Description | Responsive Mode - Jayne Hope - SAVE: Single-Administration Vaccine Enhancement |
| Amount | £114,896 (GBP) |
| Funding ID | BB/R008272/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 06/2021 |
| Description | Responsive Mode - Kellie Watson - The role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken. |
| Amount | £801,119 (GBP) |
| Funding ID | BB/P022049/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2020 |
| Description | Role of distinct mononuclear phagocyte subsets in oral prion disease pathogenesis |
| Amount | £550,023 (GBP) |
| Funding ID | BB/S005471/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 04/2022 |
| Description | Services work II - running of fluidigm arrays |
| Amount | £36,300 (GBP) |
| Organisation | Cobb Vantress |
| Sector | Private |
| Country | United States |
| Start | 01/2023 |
| End | 08/2023 |
| Description | Short term support for Dr Sam Sives |
| Amount | £8,692 (GBP) |
| Funding ID | BB-R506564-1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 03/2021 |
| Description | Single cell transcriptomics as a disruptive tool for aquaculture research: a cellular atlas of the liver response to infection in Atlantic salmon |
| Amount | £10,000 (GBP) |
| Organisation | Scottish Universities Life Sciences Alliance |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 07/2020 |
| Description | Sub-award from BBSRC Flexible Talent Mobility Award (BB/R506564/1). Professor Lonneke Vervelde & Dr Sam Ellis. 'Identification of protective epitopes for control of avian influenza virus'. |
| Amount | £14,138 (GBP) |
| Funding ID | BB/R506564/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 03/2019 |
| Description | Sub-award from BBSRC Flexible Talent Mobility Award (BB/R506564/1). Professor Lonneke Vervelde, Dr Kate Sutton & Proxima Concepts Ltd. 'Evaluation of a novel adjuvant for mucosal immunistion of poultry'. |
| Amount | £12,830 (GBP) |
| Funding ID | BB/R506564/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 03/2019 |
| Description | Sub-award from BBSRC Impact Acceleration Account (BB/S506722/1). Dr Adam Balic 'Dendritic cell targeting to enhance vaccination efficacy in immunologically naïve chicks' |
| Amount | £9,544 (GBP) |
| Funding ID | BB/S506722/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | Sub-award from BBSRC Impact Accelerator Account (BB/S506722/1). Professor Lonneke Vervelde 'Broad spectrum avian influenza vaccine based on epitopes of low variability' |
| Amount | £20,000 (GBP) |
| Funding ID | BB/S506722/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | T-cell receptor rearrangements as a potential diagnostic tool in feline infectious peritonitis |
| Amount | £9,848 (GBP) |
| Funding ID | s22-1157-1196 |
| Organisation | Petplan Charitable Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2024 |
| Description | The Pirbright Institute Flexible Talent Mobility Account Innovation Fellowship |
| Amount | £19,636 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 10/2020 |
| Description | The impact of gut microbiome on the innate immune response against enteric coronaviruses |
| Amount | £406,514 (GBP) |
| Funding ID | BB/W009870/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 06/2025 |
| Description | The role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken. |
| Amount | £640,895 (GBP) |
| Funding ID | BB/P022049/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2021 |
| Description | UK International coronavirus network (UK-ICN) |
| Amount | £510,207 (GBP) |
| Funding ID | BB/W003287/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | Veterinary vaccine fellowships for female post-docs in developing countries |
| Amount | £157,467 (GBP) |
| Organisation | International Development Research Centre |
| Sector | Public |
| Country | Canada |
| Start | 12/2019 |
| End | 12/2021 |
| Description | Veterinary vaccine fellowships for female post-docs in developing countries |
| Amount | £157,467 (GBP) |
| Organisation | International Development Research Centre |
| Sector | Public |
| Country | Canada |
| Start | 12/2019 |
| End | 12/2021 |
| Description | chicken synthetic microbiota (chisyn) |
| Amount | £77,801 (GBP) |
| Organisation | Technical University of Munich |
| Sector | Academic/University |
| Country | Germany |
| Start | 09/2023 |
| End | 05/2025 |
| Description | enhancing the efficacy and ease of application of existing endemic livestock disease vaccines via novel adjuvants and delivery systems |
| Amount | £8,843 (GBP) |
| Funding ID | BB/W02053X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2022 |
| End | 05/2023 |
| Description | flu trailmap (transmission and risk of avian influenza: learning more to advance preparedness) |
| Amount | £864,340 (GBP) |
| Funding ID | BB/Y007352/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 11/2025 |
| Description | international veterinary vaccinology network |
| Amount | £457,370 (GBP) |
| Funding ID | MR/R005958/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 09/2023 |
| Description | international veterinary vaccinology network (ivvn) |
| Amount | £1,306,006 (GBP) |
| Funding ID | MR/Y033744/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 11/2025 |
| Description | zoetis studentship |
| Amount | £15,000 (GBP) |
| Funding ID | R-3381 |
| Organisation | Zoetis |
| Sector | Private |
| Country | United States |
| Start | 01/2022 |
| End | 08/2026 |
| Title | Bovine MHC genotyping using MiSeq |
| Description | A complete platform for enabling the characterising MHC diversity in bovine. It describes the whole process including PCR amplification, sequence analysis and bioinformatics pipeline required to perform high resolution, high throughput analysis of bovine MHC |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Application of this tool is enabling us to perform a global scale analysis of bovine MHC which had previously been technically non-feasible. Based on this technique we are now analysing several thousand samples collected from countries around the world including Pakistan, Kenya, Uganda, Cameroon, Zambia, Brazil, UK and Italy. We have already hosted researchers from Kenya and Zambia who wanted to learn how to use and apply the method. |
| Title | ELISpot for PRRSV |
| Description | An ELISpot for PRRSV was developed to investigate cellular immune responses in vaccine development studies. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The tool is essential to do vaccine efficacy studies. |
| Title | In vitro culture of bovine intestinal enteroids |
| Description | We have developed the methodology for generating and culturing bovine intestinal enteroids - stem cell-derived 3-dimensional structures, including a lumen and crypts, and with all cell types represented. Importantly these are able to be continuously passaged, and can be cryopreserved. Therefore, they are (i) a more physiologically relevant in vitro model for the bovine intestine, (ii) represent a viable route to replacing animal use in the study of the bovine intestine - for example, in host-pathogen studies of important bovine enteric pathogens (potentially including drug screening). |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | While it is too early to assess impact of our research tool, we have already had multiple enquiries for collaboration and requests for advice on use of the technique, both within Roslin Institute and from external institutions. We predict that this will lead to a reduction in animal use as the use of enteroids becomes more wiodespread. |
| Title | India flu - in vitro assays |
| Description | Development of in vitro assays for assessment of candidate gene function in response to flu infection |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Provided To Others? | No |
| Impact | These assays allow us to verify the effects of candidate genes upon flu infection, without using whole animal experiments |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523026/ |
| Title | Label free shotgun proteomic method for measuring fish blood plasma proteins after immunization - coupled to repeated sampling of blood from same individual |
| Description | This tool involves the tryptic digestion of a protein sample, before the resultant peptides are injected into and separated by liquid chromatography (we used an UltiMate 3000 RSLCnano system; Dionex/Thermo Scientific) coupled to a Q Exactive Plus quadrupole-equipped orbitrap mass spectrometer (Thermo Scientific). Following mass spectrometry scans, the raw data was analysed using the MaxQuant program (Cox and Mann, 2008; Nat. Biotechnol. 26, 1367-1372), using a label-free quantification method (Cox et al., 2014; Mol. Cell. Proteomics 13, 2513-2526). Identification of proteins was done against the latest rainbow trout reference assembly (GCA_002163495.1). Development of this tool during the award is making a broad positive impact to ongoing research within the groups of the award holders (PI: Macqueen, Former PI: Dooley, Co-I: Stead). The label-free shotgun proteomics approach developed within the project is being used routinely in several projects led by Macqueen to dissect the basis of physiological traits relevant to salmonid aquaculture, and it now a routine method in an armoury of omics tools used by his group. The same approach is being used in a BBSRC PhD studentship (BB/M010996/1) co-supervised with Dooley and Stead. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | No |
| Impact | A major objective of BB/M026345/1 was to reduce the number of fish used in vaccine testing and immune research. We have successfully developed an approach that combines the use of repeated blood sampling of the same individual during an immune response, with high power proteomics that can measure a large number of proteins simultaneously. This advance allows the generation of more in-depth data regarding the immune response but using far fewer fish. It also gives us direct empirical insights into individual variation in immunological traits missed by more typical experimental designs (i.e. where data is pooled from a large number of animals). Such information will facilitate the identification of variables that separate vaccine-responsive and non-responsive animals, and help inform the design of new and/or more protective, aquaculture vaccines. |
| Title | Multiplexed quantitative PCR-based platform for evaluation of chicken immune responses |
| Description | To address the need for sensitive high-throughput assays to analyse avian innate and adaptive immune responses, we developed and validated a highly multiplexed qPCR 96.96 Fluidigm Dynamic Array to analyse the transcription of chicken immune-related genes. This microfluidic system permits the simultaneous analysis of expression of 96 transcripts in 96 samples in 6 nanolitre reactions and the 9,216 reactions are ready for interpretation immediately. A panel of 89 genes was selected from an RNA-seq analysis of the transcriptional response of chicken macrophages, dendritic cells and heterophils to agonists of innate immunity and from our own and from published transcriptome data. Recently we designed a second panel of 89 genes that partly overlaps with the published gene panel but ~a third of the genes are typically regulated during infections of chickens with viruses. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The tool supported obtaining further funding (EU VetBioNet to develop the viral gene set), FTMA, ICRAD. |
| Title | Single cell sequencing |
| Description | Highly reliable single cell or nucleus sequencing using 10X Genomics or Parse Biosciences Platform, available to researchers at the University of Edinburgh and externally through a Genomics Facility established at the Roslin Institute. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Since we established the Genomics Facility at the Roslin Institute, we have enabled approximately 20 different research groups to uptake transformative single cell sequencing technologies in their research, including a range of model and non model species (to date: human, mouse, pig, chicken, sheep, cattle, Atlantic salmon, oyster, shrimp, dog, zebrafish, medaka, among others). |
| URL | https://www.ed.ac.uk/roslin/facilities-resources/genomics-platform |
| Title | Technology assay or reagent - Parallel reaction monitoring for measuring fish target blood plasma proteins after immunization - coupled to repeated sampling of blood from same individual |
| Description | A targeted proteomics parallel reaction monitoring (PRM) approach has been developed during the project, with the work led by Co-I Stead, lead Proteomics Technologist within the University of Aberdeen core Proteomics unit. The approach involves the use of heavy-labelled versions of the tryptic peptides targeted by PRM, which are spiked into the sample mix. Fisher Thermo Scientific software PinPoint is used to determine quantitative levels of target proteins. This work is being further developed in a BBSRC PhD studentship, but a publication reporting the findings of the award should be published within 2018. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Knowledge gained during the award is opening-up a new branch of PRM tools that the Aberdeen core proteomics facility can offer to researchers in the future. A major objective of BB/M026345/1 was to reduce the number of fish used in vaccine testing and immune research. We have successfully developed an approach that combines the use of repeated blood sampling of the same individual during an immune response, with high power proteomics that can measure a large number of proteins simultaneously. This advance allows the generation of more in-depth data regarding the immune response but using far fewer fish. It also gives us direct empirical insights into individual variation in immunological traits missed by more typical experimental designs (i.e. where data is pooled from a large number of animals). Such information will facilitate the identification of variables that separate vaccine-responsive and non-responsive animals, and help inform the design of new and/or more protective, aquaculture vaccines. |
| Title | avian 2D intestinal organoids |
| Description | After successfully developing avian 3D enteroid technology the next step was to develop a 2D model that can be applied on transwell insert. Although the 3D model is extremely versatile and relatively cheap, they can not be employed in combination with transwell inserts to allow to study for example transepithelial resistance. To expand our toolbox of in vitro avian tissue models we then developed 2D enteroids. The preparation and culture method are highly similar to the mammalian 2D enteroids and could therefore not be patented as done for the 3D enteroids. The chicken 2D enteroid model recapitulates all major differentiated cell lineages and self-organises into an epithelial and mesenchymal sub-layer. Functional studies demonstrated they formed a tight cell layer with minimal paracellular flux and a robust epithelial integrity. The chicken 2D enteroids provide a useful ex vivo model to study intestinal cell biology and innate immune function, and have potential uses in screening of nutritional supplements, pharmaceuticals, and bioactive compounds. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | This novel chicken tissue model was funded by an industrial partner and supported by BBSRC ISP. After successfully establishing the chicken 2D model the company then went on to fund the next project to set up a similar bovine 2D enteroid model. |
| URL | https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-021-01010-z |
| Title | avian 3D intestinal organoids |
| Description | We have developed complex multilobulated 3D chicken enteroids from intestinal embryonic villi and adult crypts. These avian enteroids develop optimally in suspension without the structural support required to produce mammalian enteroids, resulting in an inside-out enteroid conformation with media-facing apical brush borders. Histological and transcriptional analyses show these enteroids comprise of differentiated intestinal epithelial cells bound by cell-cell junctions, and notably, include intr |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | The development of this tools has led to follow up funding: BB/V019899/1 in which the technology is employed to study determinants of virulence or emerging virulent non-notifiable avian influenza viruses. The technology may be developed as diagnostic tool to rapidly asses virulence of viruses and thereby may reduce the number of animals used for IVPI scores. BB/V011286/1 in which the technology is employed to study the effect of innate immune pressure and host jumps on evolution of newly emerg |
| URL | https://www.nature.com/articles/s42003-021-01901-z |
| Title | bovine 2D intestinal organoids |
| Description | After successfully developing avian 2D enteroid technology we developed a bovine 2D enteroid model that can be applied on transwell inserts. The bovine 2D enteroid model is derived from 3D enteroids that are dissociated into single cells. Confluent monolayers are established that recapitulate all major differentiated cell lineages. Functional studies demonstrated they formed a tight cell layer with a robust epithelial integrity. The bovine 2D enteroids provide a useful ex vivo model to study intestinal cell biology and innate immune function, host pathogen interactions and have potential uses in screening of nutritional supplements, pharmaceuticals, and bioactive compounds. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | The outcomes of this work will be published in 2022. |
| Title | Avianbase: a community resource for bird genomics |
| Description | The Avianbase Project is an initiative led by the Roslin Institute in collaboration with the Avian Phylogenomics Consortium and Ensembl to make the initial sequence and annotation available for 48 bird species within the Ensembl framework. The Avianbase Project is using the Ensembl infrastructure to share data brought together by the Avian Phylogenomics Consortium (as part of the Avian Genome Consortium) for 48 birds. Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released by the Avian Phylogenomics Consortium. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | The Avianbase project was overviewed in the paper of 2015 (Lél Eöry, M Thomas P Gilbert, Cai Li, Bo Li, Alan Archibald, Bronwen L Aken, Guojie Zhang, Erich Jarvis, Paul Flicek and David W Burt (2015) Avianbase: a community resource for bird genomics. Genome Biology 16:21) which has been sited by over 18 times. It provides a valuable one-stop-shop to access a wealth of Avian genomic information to allow easy interrogation of genotype across species. |
| URL | http://avianbase.narf.ac.uk/index.html |
| Title | Bacterial 16S rRNA gene metabarcoding of faecal samples from young mice, aged mice and aged mice given young bedding |
| Description | Project: PRJEB36358 The effects of ageing on M cells and the faecal and caecal microbiota composition in mice The intestinal microbiota helps to maintain the maturation and functioning of the mucosal immune system with its dysbiosis causing detrimental effects. Ageing is known to have a significant impact on the composition of the gut microbiota. Although relatively stable for much of adulthood, ageing induces significant shifts in the intestinal microbiota. Therefore, restoring a "healthy" gut microbiota may have beneficial effects on mucosal immunity. In this study, we studied further the effects of ageing on M-cell status and gut microbiota composition. Faecal samples were collected from aged mice before and at 4 and 6 wk after passive microbiota transfer and from young donor mice. DNA was extracted and prepared for 16S rRNA gene sequencing, targeting the V3 hypervariable region. The sequence files generated with the primers removed are publicly available through the European Nucleotide Archive (ENA) under the project accession number PRJEB36358 https://www.ebi.ac.uk/ena/browser/view/PRJEB36358 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | These data were included in the following manuscripts: Submitted to Cell Reports (Feb, 2020) Donaldson DS, Pollock J, Vohra P, Stevens MP & Mabbott NA. (2020) Microbial stimulation reverses the age-related decline in M cells in aged mice. Submitted to Cell Reports 17/2/20. Submitted to bioRxiv (Feb, 2020) Donaldson DS, Pollock J, Vohra P, Stevens MP & Mabbott NA. (2020) Microbial stimulation reverses the age-related decline in M cells in aged mice. bioRxiv doi: https://doi.org/10.1101/2020.02.17.943514 |
| URL | https://www.ebi.ac.uk/ena/data/view/PRJEB36358 |
| Title | India flu - chicken transcriptome |
| Description | Transcriptomes from brain, lung and ileum tissue from chicken in response to high and low path avian flu |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Identification of genes involved in resistance/susceptibility to avian flu |
| Title | India flu - crow transcriptome |
| Description | Transcriptomes from brain, lung and ileum tissue from crow in response to high and low path avian flu |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Identification of genes involved in resistance/susceptibility to avian flu |
| Title | India flu - duck transcriptome |
| Description | Transcriptomes from brain, lung and ileum tissue from duck in response to high and low path avian flu |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Identification of genes involved in resistance/susceptibility to avian flu |
| Title | India flu - goose transcriptome |
| Description | Transcriptomes from brain, lung and ileum tissue from goose in response to high and low path avian flu |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Identification of genes involved in resistance/susceptibility to avian flu |
| Title | India flu - pigeon transcriptome |
| Description | Transcriptomes from brain, lung and ileum tissue from pigeon in response to high and low path avian flu |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Identification of genes involved in resistance/susceptibility to avian flu |
| Title | India flu - turkey transcriptome |
| Description | Transcriptomes from brain, lung and ileum tissue from turkey in response to high and low path avian flu |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Identification of genes involved in resistance/susceptibility to avian flu |
| Title | MOESM2 of Development of in vitro enteroids derived from bovine small intestinal crypts |
| Description | Additional file 2. Details of the genes found in each co-expression cluster derived from the mRNA-seq analysis data. Table providing details of the genes found in each co-expression cluster in the network graph derived from the mRNA-seq analysis data. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM2_of_Development_of_in_vitro_enteroids_derived_fro... |
| Title | MOESM2 of Development of in vitro enteroids derived from bovine small intestinal crypts |
| Description | Additional file 2. Details of the genes found in each co-expression cluster derived from the mRNA-seq analysis data. Table providing details of the genes found in each co-expression cluster in the network graph derived from the mRNA-seq analysis data. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM2_of_Development_of_in_vitro_enteroids_derived_fro... |
| Title | MOESM4 of Development of in vitro enteroids derived from bovine small intestinal crypts |
| Description | Additional file 4. Representative GO term enrichment annotations for the genes in the largest 50 co-expression clusters. Table listing the representative GO term enrichment annotations for the genes in the largest 50 co-expression clusters derived from the network graph. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM4_of_Development_of_in_vitro_enteroids_derived_fro... |
| Title | MOESM4 of Development of in vitro enteroids derived from bovine small intestinal crypts |
| Description | Additional file 4. Representative GO term enrichment annotations for the genes in the largest 50 co-expression clusters. Table listing the representative GO term enrichment annotations for the genes in the largest 50 co-expression clusters derived from the network graph. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM4_of_Development_of_in_vitro_enteroids_derived_fro... |
| Title | Mathematical model for predicting vaccine effectiveness with accompanied R Shiny app |
| Description | A mathematical model with an interactive R Shiny app was created to model the epidemiological consequences of vaccination with imperfect vaccines of various types, administered using different strategies to animal herds with different replacement rates and heterogeneity in vaccine responsiveness. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | no impact yet |
| URL | https://www.wiki.ed.ac.uk/display/saphir/ |
| Title | Mechanistic model for within host PRRS virus infection dynamics |
| Description | A mechanistic model was developed to assess candidate immune mechanisms responsible for viremia rebound. The model was fitted to viremia data from a large scale PRRS virus infection experiment. The model is published in Go N. et al. 2019. How to prevent viremia rebound: evidence from a PRRSv data-supported model of immune response. BMC Systems Biol. https://doi.org/10.1186/s12918-018-0666-7 |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Now collaborative research grant applications |
| Title | PRJEB14552 |
| Description | The MHC region contains many genes that are key regulators of both innate and adaptive immunity including the polymorphic MHCI and MHCII genes. Consequently, the characterisation of the repertoire of MHC genes is critical to understanding the variation that determines the nature of immune responses. Currently our knowledge of the bovine MHCI repertoire is limited with only the Holstein-Friesian breed having been studied in any depth. Traditional methods of MHCI genotyping are of low resolution and laborious and this has been a major impediment to a more comprehensive analysis of the MHCI repertoire of other cattle breeds. Next-generation sequencing (NGS) technologies have been used to enable high throughput and much higher resolution MHCI typing in a number of species. In this study we have developed a MiSeq platform approach and requisite bioinformatics pipeline to facilitate typing of bovine MHCI repertoires. The method was validated initially on a cohort of Holstein-Friesian animals and then demonstrated to enable characterisation of MHCI repertoires in African cattle breeds, for which there was limited or no available data. During the course of these studies we identified >140 novel classical MHCI genes and defined 62 novel MHCI haplotypes, dramatically expanding the known bovine MHCI repertoire. Construction protocol: Total RNAs were extracted from white blood cell pellets prepared form blood obtained by venepuncture using Tri-reagent (Sigma-Aldrich, Dorset) and cDNA prepared using the Reverse Transcription Kit (Promega, WI); both according to the manufacturer's protocols. PCR amplification was performed with the Phusion HF PCR kit (NEB, Herts.) using bovine MHCI primers that included Illumina sequencing primer annealing sites, multiple sample identifier tags (D501-508 and D701-712) and Illumina ligation adaptors. PCR products from ~96 animals were pooled to form a library which was then sequenced on the Illumina Miseq platform. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | These data represent a reference dataset of novel MHC alleles in cattle and may underpin research into cattle immunogenetic diversity for many years in the future |
| URL | https://www.ebi.ac.uk/ena/data/view/PRJEB14552 |
| Title | PRJEB14979 |
| Description | Marek's Disease Virus (MDV) is a widespread alphaherpesvirus of poultry that causes Marek's disease (MD) characterised by fatal visceral CD4+ TCRaß+ T cell tumours at high incidence in susceptible hosts. As is the case with many virus-induced tumours, immortal cell lines harbouring viral genome have been generated from ex vivo cultures of MD tumours. As readily-available sources of large numbers of cells of a uniform type, MDV-transformed lymphoblastoid cell lines (LCL) have proved extremely valuable in studying virus-host interaction. While the viral genome is held in a latent state in most of the cells, a minor population of cells display spontaneous reactivation identifiable by the expression of lytic viral genes such as pp38. The process of spontaneous reactivation in these cell populations offers the opportunity for investigating the biological processes involved in the reactivation events. For this, we used two lymphoblastoid cell lines derived from lymphomas induced by pRB1B-UL47eGFP, a recombinant MDV engineered to express EGFP fused with the UL47. We used Fluorescence-activated cell sorting (FACS) to purify the rare EGFP-positive cell population with spontaneously activating viral genome from the majority EGFP-negative cells and analysed their gene expression profiles by RNA-sequencing using Illumina HiSeq2500. The reads generated were mapped using TopHat and gene expression levels were analysed by edgeR. Ingenuity pathway analysis software on more than 2000 differentially-expressed genes between the lytically infected (EGFP-positive) and latently infected (EGFP-negative) cell populations was used identify major biological pathways involved in the reactivation. These studies revealed that amongst others, transcripts directly involved in T activation such as CD3 complex, CD28, ICOS, phospholipase C, CD3 complex were down-regulated following reactivation of the virus in the LCL. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | These data detail the gene expression changes during spontaneous activation of MDV and will be useful to researchers investigating the mechanism of action of this important virus, as well as in vaccine design |
| URL | https://www.ebi.ac.uk/ena/data/view/PRJEB14979 |
| Title | Transcriptomic analysis of the follicle associated epithelium of Peyer's Patches, intestinal villous epithelium and ileum from young and aged mice |
| Description | mRNA profiles of follicle associated epithelium of Peyer's Patches (n=3 mice), intestinal villous epithelium (n=4-6 mice) and ileum (n=4 mice) from young and aged mice. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Data published in the following manuscript Donaldson DS, Shih BB, Mabbott NA. Aging-Related Impairments to M Cells in Peyer's Patches Coincide With Disturbances to Paneth Cells. Front Immunol 2021;12:761949. PMID: 34938288 |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE182252 |
| Title | WGS - Hyline flu -2 |
| Description | Whole genome sequences (30x) of ~197 chickens (survivors of highly pathogenic avian flu and controls) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | These data have allowed for GWAS analysis that has identified significant genomic regions for avian flu survival. Candidate genes/SNPs have subsequently been identified. Understanding the genetic basis of resistance to avian flu has huge potential implications for both the poultry industry and human health |
| Title | mRNA-seq analysis data derived from in vitro bovine ileum enteroid cultures |
| Description | In vitro 3D enteroid, or "mini gut", cultures were prepared from bovine small intestinal (ileal) crypts. mRNA was isolated from bovine small intestinal crypts, freshly prepared enteroids (P0) and enteroids after multiple serial passages (P1-5). Global gene expression was compared in these samples by mRNA-seq. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Significant interest from many other researchers was generated from these data |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112674 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | AquaGen |
| Country | Norway |
| Sector | Private |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | Hellenic Centre for Marine Research (HCMR) |
| Country | Greece |
| Sector | Private |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | Norwegian University of Life Sciences (NMBU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | Polish Academy of Sciences |
| Country | Poland |
| Sector | Public |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | University of Aberdeen |
| Department | Paediatrics Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | University of Padova |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | University of Santiago de Compostela |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | AQUA-FAANG: Advancing European aquaculture by genome functional annotation |
| Organisation | Xelect Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Deputy coordinator of the project/collaboration. Work package leader. Co-led proposal writing. |
| Collaborator Contribution | Diverse academic contributions to complex project |
| Impact | $6 million funding. Established key links for aquaculture species within the broader FAANG community and links to BovReg and GeneSwitch project funded in the same call |
| Start Year | 2017 |
| Description | Adisseo consortium |
| Organisation | Adisseo |
| Country | France |
| Sector | Private |
| PI Contribution | Obtained a Adisseo Research grant |
| Collaborator Contribution | We will bring in our avian organoids technology to study the effect of microbiome on immune development of the gut and resilience to avian influenza. |
| Impact | Due to long start up time to set up a consortium agreement the project did not start in 20212 but end 2022, no out put yet. Collaboartive project with INRAE France and LMU Germany funded by Adisseo |
| Start Year | 2022 |
| Description | AquaLeap consortium |
| Organisation | Centre For Environment, Fisheries And Aquaculture Science |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | Hendrix Genetics |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | Scottish Aquaculture Innovation Centre |
| Country | United Kingdom |
| Sector | Multiple |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | University of Aberdeen |
| Department | Institute of Biological and Environmental Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | University of Exeter |
| Department | College of Life and Environmental Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | University of Stirling |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | AquaLeap consortium |
| Organisation | Xelect Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Co-principal investigator on grant supporting collaboration. Took over as overall consortium coordinator in Spring 2022, when Prof. Ross Houston moved into industry. Leading on research to assemble the flat oyster genome and investigating novel methods for capturing structural variation in Atlantic salmon genetics investigations. |
| Collaborator Contribution | Prof. Ross Houston (Roslin) leading consortium until Spring 2022. SAIC provided cash funding to support collaboration. Hendrix providing key samples to investigate structural variation. Exeter and Stirling collaborating on genome assembly of aquaculture species. |
| Impact | The AquaLeap consortium has published 18 peer reviewed articles to date, 8 of which are assigned to this award. We have developed novel genetic resources and tools for four species of great importance of potential for UK aquaculture. |
| Start Year | 2019 |
| Description | Cellular basis of viral vaccine protection in Atlantic salmon |
| Organisation | MSD Animal Health |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | This is a new BBSRC responsive mode funded project with MSD Animal Health as the main industry partner, and the University of Aberdeen as the main academic partner. At this stage, my major contribution has been to lead the successful bid for BBSRC responsive mode funding (£500,839 to Roslin as PI; £387,403 to Aberdeen as Co-PI) and to coordinate the grant agreement. The project starts from May 1st 2022. Below is the summary of the project: Our aim is to create a large up-step in understanding of how vaccination against a major problem viral disease (called pancreas disease) leads to immune protection through dynamic changes in immune cells. We will apply single cell transcriptomics to samples taken from a carefully designed vaccination experiment, designed to link early changes in immune cell expression to immune protection generated over months. The first major aim is to describe the full diversity of different cell types in the major tissues of the salmon immune system, including how these cells respond to viral vaccination. We will compare two registered pancreas disease vaccines with very different formulations to understand cellular mechanisms leading to differences in disease protection. The second major aim is to identify immune cell types, and specific marker genes for these cells, correlated with vaccine protection. A final objective is to use the results to develop a cost-effective platform that can be used to accurately predict disease protection early post-vaccination. In addition to creating major knowledge advancement on the cellular basis of protective immune responses in fish, the results will have applications in vaccine research and development, opening up strategies to assess vaccine efficacy using faster more cost-effective strategies and fewer animals. This may lead to improvements in vaccine design and testing that can positively impact the sustainability of salmon aquaculture while promoting fish welfare. |
| Collaborator Contribution | MSD Animal Health co-designed the experiments proposed to BBSRC and supported writing of the proposal. They are now working on the collaboration agreement, and from Q3 of 2022 will coordinate fish experiments from Norway necessary to achieve the project. |
| Impact | So far, BBSRC responsive mode grant funded. |
| Start Year | 2022 |
| Description | Centre for Tropical Livestock Genetics and Health (CTLGH) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Research contribution to the CTLGH result framework. |
| Collaborator Contribution | Research links and collaboration with its member partners in the UK and Africa. |
| Impact | No output to report yet. |
| Start Year | 2017 |
| Description | Centre for tropical livestock genetics and health (CTLGH) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Mick Watson is co-leading programme 5 (informatics and bioresources) programme of CTLGH which aims to collect data on genotype and phenotype into a central database which can subsequently be mined for useful associations. So far we have ensured that scientists have access to the latest high performance computing environment for research, we have analysed and continue to analyse hundreds of farm animal genomes from LMIC countries, and we have built the data portal (http://data.ctlgh.org) |
| Collaborator Contribution | The partners are involved in all programmes, which include:Program 1: Harnessing genetic variability among indigenous and exotic breeds of cattle (as well as their crosses) to develop genetic and genomic tools that will be used to improve productivity under harsh tropical conditions and to mitigate the impact of cattle on climate change. Program 2: Harnessing genetic variability in tropical productivity and adaptation among various breeds of Chickens. Program 3: Development and application of precision breeding (through novel reproductive and germplasm technologies) to achieve step changes in livestock genetic improvement. Program 4: Understanding the genetic and molecular mechanisms underlying the tolerance of certain cattle and poultry breeds to tropical diseases and pests. Program 5: A shared global data and biological sample resource to support continued research and development on tropical livestock genetics and health. |
| Impact | The data portal so far: http://data.ctlgh.org The collaboration is multi-disciplinary, bringing together geneticists, parasitologists, virologists, epidemiologists and data scientists together. |
| Start Year | 2016 |
| Description | Centre for tropical livestock genetics and health (CTLGH) |
| Organisation | Scotland's Rural College |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Mick Watson is co-leading programme 5 (informatics and bioresources) programme of CTLGH which aims to collect data on genotype and phenotype into a central database which can subsequently be mined for useful associations. So far we have ensured that scientists have access to the latest high performance computing environment for research, we have analysed and continue to analyse hundreds of farm animal genomes from LMIC countries, and we have built the data portal (http://data.ctlgh.org) |
| Collaborator Contribution | The partners are involved in all programmes, which include:Program 1: Harnessing genetic variability among indigenous and exotic breeds of cattle (as well as their crosses) to develop genetic and genomic tools that will be used to improve productivity under harsh tropical conditions and to mitigate the impact of cattle on climate change. Program 2: Harnessing genetic variability in tropical productivity and adaptation among various breeds of Chickens. Program 3: Development and application of precision breeding (through novel reproductive and germplasm technologies) to achieve step changes in livestock genetic improvement. Program 4: Understanding the genetic and molecular mechanisms underlying the tolerance of certain cattle and poultry breeds to tropical diseases and pests. Program 5: A shared global data and biological sample resource to support continued research and development on tropical livestock genetics and health. |
| Impact | The data portal so far: http://data.ctlgh.org The collaboration is multi-disciplinary, bringing together geneticists, parasitologists, virologists, epidemiologists and data scientists together. |
| Start Year | 2016 |
| Description | Collaboration ANSES |
| Organisation | French Agency for Food, Environmental and Occupational Health & Safety (ANSES) |
| Country | France |
| Sector | Public |
| PI Contribution | My research team will work in the ANSES laboratories to set up organotypic avian cultures (intestinal organoids) of chicken, turkey and Guinea fowl which will be a unique opportunity. The organoids will then be infected with a variety of coronaviruses and avian influenza viruses (low and high pathogenic) and the viral replication will be analysed at different time points post infection. The RNA will be isolated and transported back to the UK to investigate the species specific immune responses using a high throughput qPCR array. The Roslin team will train the scientist at ANSES how to culture organoids whereas the team at ANSES will train the ECRs in virological techniques and working in a high containment laboratory. |
| Collaborator Contribution | The team at ANSES will contribute a lot of staff time, the animals, and will do the infection experiment in their high containment laboratory. In addition they will analyse the virus replication (RT-qPCR, egg titration and plaque assays) and we will write a joined publication describing the outcomes of this collaborative project. The data will feed in to many other projects related to avian corona and avian influenza viruses that are ongoing in the Vervelde group. |
| Impact | A collaborative project with ANSES, Ploufragan laboratory (reference lab for avian influenza), was initiated and funded by the BBSRC mitigation fund. This is a multidisciplinary collaboration in which the Roslin ECRs and PI will contribute their expertise in organotypic avian cultures (organoids) and the team at ANSES will contribute their virological expertise, the capacity to work with highly pathogenic avian influenza and their access to poultry species that we do not have in the U.K. (including guinea fowl, SPF turkeys and SPF ducks). The output of this collaboration will be joined peer reviewed publications on on host specific viral entry and immune responses (avian corona viruses and avian influenza viruses), preliminary data for follow on funding and future access to a wealth of virus strains and high containment laboratory and animal facilities. |
| Start Year | 2022 |
| Description | Collaboration with AB Vista |
| Organisation | AB Vista |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We are researching the activity of ovodefensins, naturally-occurring egg peptides with antimicrobial properties. With BBSRC LINK funding we are exploring the activity of diverse ovodefensins from multiple avian species, dissecting their structure and mode of action, and exploring their capacity to act as growth promoters and novel therapeutics. |
| Collaborator Contribution | AB Vista have made a substantial cash contribution to the LINK project (c. £460k) and also provide access to natural populations of broilers for feed trials using diets supplemented (or not) with Trichoderma-expressed ovodefensins. They also support analysis of the impact of such diets on intestinal microbiota and metabolites. |
| Impact | Commercially sensitive and to be disclosed following scrutiny for Intellectual Property. |
| Start Year | 2012 |
| Description | Collaboration with Boehringer Ingelheim |
| Organisation | Boehringer Ingelheim |
| Country | Germany |
| Sector | Private |
| PI Contribution | The collaboration is to advance diagnostics in relation to specific bacterial infections in pigs. We are carrying out basic science investigating antigens and immune responses |
| Collaborator Contribution | The company is providing reagents and expertise in this subject area |
| Impact | Part-funded PhD studentship |
| Start Year | 2017 |
| Description | Collaboration with Moredun Research Institute |
| Organisation | Moredun Research Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | The grant has two partners, Roslin and Moredun Institutes. The major contribution from Roslin is to develop mouse models and in vitro bovine organoid models to study the entry mechanisms of Mycobacterium avium paratuberculosis into the host. Roslin will also develop a library of mutant strains of the bacteria. The information gained at Roslin will be compared with outputs from in vivo calf studies and parallel in vitro analyses at Moredun. This will allow optimisation of models to study bacterial entry mechanisms and enable comparisons of how well the in vitro models mimic in vivo events. |
| Collaborator Contribution | At the Moredun research Institute, complementary studies of the entry mechanisms of Mycobacterium avium paratuberculosis into the bovine host are being undertaken. These involve studies of the natural host, the calf and comprise in vivo studies. Alongside this, efforts to develop alternative in vitro methods and to compare these to the in vivo studies will complement those at Roslin. Taken together the work at Moredun will provide essential in vivo and in vitro data allowing us to compare models and to define mechanisms for bacterial entry into the host, that could form the basis for vaccines or therapeutics in the future. |
| Impact | None yet. |
| Start Year | 2019 |
| Description | Collaboration with Wes Warren |
| Organisation | University of Missouri |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Analysis of genomic data and also single cell transcriptomic data |
| Collaborator Contribution | Access to chicken genome/transcriptomic data |
| Impact | Warren et al. Multiple chicken (Gallus gallus) genome references to advance genetic variation studies. In the 'Fourth Report on Chicken Genes and Chromosomes 2022'. Cytogenetic and Genome Research (2023) doi: 10.1159/000529376 Prof Warren will also visit Roslin for 3 months during June-Aug 2023 |
| Start Year | 2022 |
| Description | Collaborative research with Public Health England |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We provide samples and analysis of bacteria that are present in livestock that are the potential source of infections in humans |
| Collaborator Contribution | PHE analyse bacterial infections in humans and so by working in partnership we can improve our capacity to determine the source of particular infections in humans and hopefully prevent or limit these to improve public health |
| Impact | Outputs are publications as defined elsewhere as well as improved value to PHE surveillance |
| Start Year | 2015 |
| Description | Collaborator for grant BB/M003094/1 |
| Organisation | Semmelweiss University |
| Department | Faculty of Medicine |
| Country | Hungary |
| Sector | Academic/University |
| PI Contribution | Exchange of biological samples and reagents |
| Collaborator Contribution | Exchange of biological samples and reagents |
| Impact | exchange of antibodies to detect avian cellular markers |
| Start Year | 2015 |
| Description | Collaborators on grant BB/M012069 |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Performed joined animal experiment related to the grant objective 1. |
| Collaborator Contribution | Performed joined animal experiment related to the grant objective 1. |
| Impact | No output yet, project started recently. |
| Start Year | 2015 |
| Description | Collaborators on grant BB/M028208 |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Beltsville Agricultural Research Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We have performed a pilot study to investigate the susceptibility of different chicken lines to APEC. |
| Collaborator Contribution | They have performed a large scale APEC trial that informed us on how to set up the pilot trial. |
| Impact | This project only recently started, no outcomes yet. |
| Start Year | 2015 |
| Description | Daniel Perez, University of Georgia |
| Organisation | University of Georgia |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | This grant is a joint programme with the USA component directly funded by the USDA, with money going to colleagues (Dr Daniel Perez) at the University of Georgia and The USDA SEPRL lab (Dr Darrell Kapcyznski). |
| Collaborator Contribution | Dr Perez primarily contributes to the animal challenge and viral evolution experiments |
| Impact | None yet |
| Start Year | 2021 |
| Description | Designing new vaccine delivery systems for cattle |
| Organisation | Heriot-Watt University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration between Jayne Hope and Vicki Stone/Ferry Melchels at Heriot Watt University aims to develop implantable devices that will be engineered to release vaccine components under the skin of cattle at defined time points. This will enable prime-boost vaccination to be delivered in a single shot. The team at Heriot-Watt provide expertise in development of the device including materials expertise and 3D printing, whereas the team at Roslin provide in vitro and in vivo expertise to assess vaccine release, and immunogenicity. |
| Collaborator Contribution | This collaboration between Jayne Hope and Vicki Stone/Ferry Melchels at Heriot Watt University aims to develop implantable devices that will be engineered to release vaccine components under the skin of cattle at defined time points. This will enable prime-boost vaccination to be delivered in a single shot. The team at Heriot-Watt provide expertise in development of the device including materials expertise and 3D printing, whereas the team at Roslin provide in vitro and in vivo expertise to assess vaccine release, and immunogenicity. |
| Impact | This collaboration has led to a BBSRC grant funded in 2018 (BB/R008272/1). We appointed the first member of staff in September 2018 and a second member of staff will join the team in July 2019. |
| Start Year | 2017 |
| Description | Funding from Hy-Line |
| Organisation | Hy-line International |
| Country | United States |
| Sector | Private |
| PI Contribution | Provision of funding for sequencing DNA from chickens exposed to avian influenza (survivors and controls). Analysis of genomic sequence data to identify candidate genes for resistance. In vitro validation of candidate genes. |
| Collaborator Contribution | Provision of DNA samples from commercial chickens exposed to avian influenza (survivors and controls) Funding to carry out sequencing of samples. |
| Impact | Identification of significant candidate genes for resistance to avian influenza |
| Start Year | 2017 |
| Description | GD animal health Deventer, collaborators on grant BB/M01206911 |
| Organisation | GD Animal Health |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | GD Animal Health has performed VN assays for our project In 2021 his longstanding collaboration has resulted in the ICRAD FluNuance consortium, co funded by the BBSRC. |
| Collaborator Contribution | provided us with antisera, protocols and virus |
| Impact | https://www.icrad.eu/wp-content/uploads/2020/11/54_abstract_FluNuance.pdf Joined ICRAD consortium BB/V019899/1 |
| Start Year | 2015 |
| Description | INRAE, Collaborators on grant BB/M028305 |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Performed a pilot study to investigate susceptibility of chicken lines to APEC. The APEC project led at INRAE by Dr C Schouler has finished but the collaborations continued with Dr S Trapp both within a H2020 consortium VetBioNet as well as a joined project funded by Adisseo (2021). This project is also in collaboration with LMU Germany Prof B Kaspers. |
| Collaborator Contribution | Analysed APEC virulence |
| Impact | Project resulted in joined peer reviewed manuscripts. |
| Start Year | 2015 |
| Description | Identification of interferon stimulated genes that control Neospora caninum in bovine cells. |
| Organisation | Complutense University of Madrid |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Using the tools from the project, specifically ISG screening protocol using fluorescent parasites, we are currently collaborating with Prof. Luis Ortega at University of Madrid to develop and bovine ISG library to screen for genes that control Neospora in bovine cells. |
| Collaborator Contribution | Prof. Luis leads the veterinary apicomplexan research at University of Madrid. He's evidence variable pathogenicity of different Neospora isolates in bovine cells and developed both fluorescent and transgenic parasites and cellular phenotypes that we can use to screen for both host and parasite genes controlling Neosporosis. |
| Impact | The collaboration has yet to produce an output. However, there's active research going on with a PhD student from Madrid visiting Roslin Institute and we will soon have a publication - currently under preparation. |
| Start Year | 2023 |
| Description | India DBT collaboration |
| Organisation | Indian Council of Agricultural Research |
| Department | National Institute of High Security Animal Diseases |
| Country | India |
| Sector | Public |
| PI Contribution | Using the tissues collected in Bhopal, we have sequenced and analysed the avian transcriptomic response to avian influenza challenge in 6 bird species (chicken, turkey, crow, goose, pigeon, duck). |
| Collaborator Contribution | All influenza challenge experiments were carried out by the team in Bhopal, tissues collected and sent over to the UK for processing and analysis |
| Impact | Identification of candidate genes for resistance to avian flu. |
| Start Year | 2014 |
| Description | LMU Prof B Kaspers Collaborators on grant BB/M028305 |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Performed pilot study to investigate susceptibility of chicken lines to APEC. |
| Collaborator Contribution | Developed histological tools. |
| Impact | The APEC project resulted in multiple joined peer reviewed manuscripts. In addition to joined papers we also applied with INRA for Adisseo funding and were awarded with a €500k project in 2021. |
| Start Year | 2015 |
| Description | Oxford University, Evolutionary ecology of infectious diseases |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on broad spectrum vaccines in which we provide the veterinary input (materials). Postdoc in my group obtain BBSRC impact accelerator award. |
| Collaborator Contribution | Collaboration on broad spectrum vaccines in which they provide bio-informatics pipeline and screening technology. |
| Impact | BBSRC IAA |
| Start Year | 2017 |
| Description | PRRS Host Genetics Consortium |
| Organisation | Iowa State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Genetic analysis of infectious disease data and mathematical modelling of PRRS infection dynamics; Contribution to experimental design of PRRS challenge and field experiments and sampling; |
| Collaborator Contribution | Access to data; access to statistical models; scientific advice for model assumptions |
| Impact | Joint manuscripts and publications: 1. Go N., Islam Z., Lunney J., Belloc C., Touzeau S.& Doeschl-Wilson A.B., 2017. Neutralizing antibodies prevent PRRS viremia rebound: evidence from a data-supported model of the immune response. PloS Comp. Biol. Under review 2. Lough G., Hess A., Dekkers JCM, Hess M., Kyriazakis I., Mulder H., Lunney J, Rowland BB, Doeschl-Wilson A.B. 2017. Harnessing longitudinal information to identify genetic variation in tolerance of pigs to Porcine Reproductive and Respiratory Syndrome virus. Genetics Selection Evolution. Under review 3. Lough G., Rashidi H., Kyriazakis I., Dekkers JCM, Hess AS, Hess MK, Deeb N, Kause A., Lunney J, Rowland BB, Mulder H and Doeschl-Wilson A.B. 2017. Use of multi-trait and random regression models to identify genetic variation in tolerance to Porcine Reproductive and Respiratory Syndrome virus. Genetics Selection Evolution, 49(1)37. 3. 4. Hess, A.S., Islam, Z., Hess, M.K., Rowland, R.R., Lunney, J.K., Doeschl-Wilson, A., Plastow, G.S. and Dekkers, J.C., 2016. Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus. Genetics Selection Evolution, 48(1), p.1.18. 5. Islam Z.U., Bishop S.C., Savill N.J. , Rowland R.R.R., Lunney J.K., Trible B and Doeschl-Wilson A.B. 2013. Quantitative analysis of Porcine Reproductive and Respiratory Syndrome (PRRS) viremia profiles from experimental infection: a statistical modelling approach. PLoS One, DOI: 10.1371/journal.pone.0083567. ( |
| Start Year | 2012 |
| Description | Proxima |
| Organisation | Proxima Concepts Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Generated preliminary data to apply for funding which was successful. |
| Collaborator Contribution | Supplied material to test in in vivo experiments to apply for funding. |
| Impact | Obtained multiple joined small and large research grants |
| Start Year | 2018 |
| Description | RVC |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We generated preliminary data for funding applications, next step will be to use their parasites in the awarded projects. |
| Collaborator Contribution | Supply of material and large scale animal trials. |
| Impact | Applied for joint grants |
| Start Year | 2014 |
| Description | Role of M cells in the sampling of mucosal antigens by B cells in Peyer's patches |
| Organisation | University of Gothenburg |
| Department | Microbiology and Immunology UGOT |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | We provided our expertise in M cell immunobiology and use of unique in vivo systems to study M cells |
| Collaborator Contribution | Prof. Nils Lycke is an expert in mucosal immunology and provided his unique systems in which to study the generation of antigen-specific IgA responses in the intestine. |
| Impact | A manuscript was published in Nature Communications (2019) describing how activated Peyer´s patch B cells sample antigen directly from M cells in the subepithelial dome to maintain gut germinal center responses Komban RJ, Stromberg A, Biram A, Cervin J, Lebrero-Fernandez C, Mabbott N, Yrlid U, Shulman Z, Bemark M & Lycke N. (2019) Activated Peyer's patch B cells sample antigen from M cells in the subepithelial dome to maintain gut germinal centre responses. Nature Communications 10:2423. |
| Start Year | 2018 |
| Description | Saphir - Horizon2020 |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | I am leader of workpackage 16: Modelling vaccine efficacy |
| Collaborator Contribution | INRA is project leader |
| Impact | -Scientific Publication: Go N., Islam Z., Lunney J., Belloc C., Touzeau S.& Doeschl-Wilson A.B., 2019. How to prevent viremia rebound: evidence from a PRRSv data-supported model of immune response. BMC Systems Biol. https://doi.org/10.1186/s12918-018-0666-7 -Popular article "How to prevent viremia rebound in virus infections? Evidence from a data-driven mathematical model for PRRS". Doeschl-Wilson A., Go N., Touzeau S. SAPHIR newsletter Nov 2017 - Issue 4. Project coordinator statement "A very innovative approach for modelling the immune response has been designed and validated." -Interactive Wiki-website: Vaccine effectiveness in the field. https://www.wiki.ed.ac.uk/display/saphir/ -Conference talks: International Vaccinology Meeting in Edinburgh, May 2018; Annual Meeting for the Society for Mathematical Biology, Sydney Australia, July 2018 and the Conference for Research Workers in Animal Disease, Chicago December 2018 |
| Start Year | 2016 |
| Description | Saphir - Horizon2020 |
| Organisation | University of Ghent |
| Department | Faculty of Veterinary Medicine |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | I am leader of workpackage 16: Modelling vaccine efficacy |
| Collaborator Contribution | INRA is project leader |
| Impact | -Scientific Publication: Go N., Islam Z., Lunney J., Belloc C., Touzeau S.& Doeschl-Wilson A.B., 2019. How to prevent viremia rebound: evidence from a PRRSv data-supported model of immune response. BMC Systems Biol. https://doi.org/10.1186/s12918-018-0666-7 -Popular article "How to prevent viremia rebound in virus infections? Evidence from a data-driven mathematical model for PRRS". Doeschl-Wilson A., Go N., Touzeau S. SAPHIR newsletter Nov 2017 - Issue 4. Project coordinator statement "A very innovative approach for modelling the immune response has been designed and validated." -Interactive Wiki-website: Vaccine effectiveness in the field. https://www.wiki.ed.ac.uk/display/saphir/ -Conference talks: International Vaccinology Meeting in Edinburgh, May 2018; Annual Meeting for the Society for Mathematical Biology, Sydney Australia, July 2018 and the Conference for Research Workers in Animal Disease, Chicago December 2018 |
| Start Year | 2016 |
| Description | Study of role of genes and transcription factors in M-cell development |
| Organisation | Keio University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | This collaboration aims to determine the role of genes and transcription factors in M-cell development in large animal species. Prof. Mabbott obtained a BBSRC travel award in 2017 to enable him to visit the Japanese partner Prof. Koji Hase in Tokyo, Japan, to discuss a potential collaboration. Prof. Mabbott through obtaining the travel award initiated this collaboration and provided the means to explore potential collaborations. |
| Collaborator Contribution | Prof. Koji Hase, the Japanese partner, has provided his extensive expertise in the role of genes and transcription factors in M cell development. During my visit his institution also provided in-kind support for our meetings and small workshop. Since this visit our discussions have continued and a BBSRC Japan partnering award was submitted in November 2018 to provide further pump priming support. |
| Impact | A BBSRC Japan partnering award was submitted in November 2018 |
| Start Year | 2017 |
| Description | Study of role of genes and transcription factors in M-cell development |
| Organisation | Keio University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | This collaboration aims to determine the role of genes and transcription factors in M-cell development in large animal species. Prof. Mabbott obtained a BBSRC travel award in 2017 to enable him to visit the Japanese partner Prof. Koji Hase in Tokyo, Japan, to discuss a potential collaboration. Prof. Mabbott through obtaining the travel award initiated this collaboration and provided the means to explore potential collaborations. |
| Collaborator Contribution | Prof. Koji Hase, the Japanese partner, has provided his extensive expertise in the role of genes and transcription factors in M cell development. During my visit his institution also provided in-kind support for our meetings and small workshop. Since this visit our discussions have continued and a BBSRC Japan partnering award was submitted in November 2018 to provide further pump priming support. |
| Impact | A BBSRC Japan partnering award was submitted in November 2018 |
| Start Year | 2017 |
| Description | Study of the role of Cxcr5 in ectopic germinal centre formation in the lung |
| Organisation | Babraham Institute |
| Department | Lymphocyte Signalling |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Our major contribution was the provision of our unique Cxcr5-floxed mice to this project. These mice were originally created on BBSRC grant BB/F019726/1. |
| Collaborator Contribution | Our lead partner, Dr. Michelle Linterman at the Babraham Institute used these mice to study the role of Cxcr5 in ectopic germinal centre formation in the lung. |
| Impact | Paper published in the Journal of Experimental Medicine in 2019 "Type I interferon induces CXCL13 to support ectopic germinal center formation" JEM 03-04-2019 issue, vol. 216 no. 3. http://doi.org/10.1084/jem.20181216 |
| Start Year | 2016 |
| Description | Study role of CXCR5 expression in ILC3 cells |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided the unique CXCR5-floxed mice created in this project to Dr. Matthew Hepworth at the University of Manchester. |
| Collaborator Contribution | The CXCR5-floxed mice were crossed to ID2 ER2 Cre - ROSA-RFP mice to enable the study of effects of CXCR5-deficiency in ILC3 cells. |
| Impact | Manuscript published in the Journal of Experimental Medicine in February 2019. PMID:30814299 "Antigen presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria" by Felipe Melo-Gonzalez, Hana Kammoun, Elza Evren, Emma Dutton, Markella Papadopoulou, Barry Bradford, Ceylan Tanes, Fahmina Fardus-Reid, Jonathan Swann, Kyle Bittinger, Neil Mabbott, Bruce Vallance, Tim Willinger, David Withers, and Matthew Hepworth |
| Start Year | 2017 |
| Description | USDA-SEPRL |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Agricultural Research Service |
| Country | United States |
| Sector | Public |
| PI Contribution | This partnership started with a joint grant from the USDA and the BBSRC to our collaborators and ourselves and continues through a second such joint award. |
| Collaborator Contribution | As above, the USDA contributes direct funding to the partner laboratory (PIs Dr Darrell Kapcyzinski and Mary Pantin-Jackwood). Their laboratory also benefits from core funding that provides further in kind benefits to the project. |
| Impact | Major outputs are: a patent awarded, and further funding. US Patent No. 11,214,799 B2 (Jan 4th 2022) entitled 'HA-specific influenza virus attenuated vaccine comprising mutations in segment 7 and uses therefor'; D.R. Kapczynski, , P. Digard, L. Vervelde and D. Suarez. BBSRC US-UK-China Collaborative grant: Predictive phylogenetics for evolutionary and transmission dynamics of newly emerging avian influenza viruses (BB/V011286/1). |
| Start Year | 2015 |
| Description | University of Delaware partnering in Jefo project |
| Organisation | University of Delaware |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Dr Ryan Arsenault is a partner in a project funded by Jefo Nutrition Inc which was awarded to L Vervelde |
| Collaborator Contribution | We have performed proof of concept experiments testing Jefo's feed additives in a chicken intestinal organoid model and samples have been sent to Dr Arsenault for further analysis on a kinase array he developed. |
| Impact | Proof of concept was successful and will be published as collaborative study in peer reviewed journal. |
| Start Year | 2022 |
| Description | Use of MHC elution to define functional parameters of bovine MHC haplotypes |
| Organisation | Technical University of Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We provide the biological context for the studies, prepare laboratory materials for analysis and subsequent in vitro validation of the data generated by our collaborators |
| Collaborator Contribution | The Jenner Institute perform the tandem nPLC-mass spectrometry and preliminary peptide identification. The Technical University of Denmark performs subsequent bioinformatics analysis. |
| Impact | Publication - PMID: 29115832. Novel information on the peptide-binding motifs of bovine MHCI molecules. Preliminary data for granny submission. Collaboration to support a post-graduate Brazilian student to undertake a 9 month FAPESP-funded scholarship at the collaborating laboratories. |
| Start Year | 2015 |
| Description | Use of MHC elution to define functional parameters of bovine MHC haplotypes |
| Organisation | University of Oxford |
| Department | Jenner Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide the biological context for the studies, prepare laboratory materials for analysis and subsequent in vitro validation of the data generated by our collaborators |
| Collaborator Contribution | The Jenner Institute perform the tandem nPLC-mass spectrometry and preliminary peptide identification. The Technical University of Denmark performs subsequent bioinformatics analysis. |
| Impact | Publication - PMID: 29115832. Novel information on the peptide-binding motifs of bovine MHCI molecules. Preliminary data for granny submission. Collaboration to support a post-graduate Brazilian student to undertake a 9 month FAPESP-funded scholarship at the collaborating laboratories. |
| Start Year | 2015 |
| Title | HA-specific influenza virus attenuated vaccine comprising mutations in segment 7, and uses thereof |
| Description | The disclosure relates to mutant recombinant influenza virus gene segment 7 with at least one mutation that modulates expression of M2 and M42 polypeptide. Also disclosed are recombinant influenza viruses comprising the mutant influenza virus gene segment 7, compositions comprising the mutant recombinant influenza virus gene segment 7, use of such mutant recombinant influenza virus gene segment 7 and mutant recombinant influenza viruses. We developed and characterized of a non-transmissible H5N2 live attenuated avian influenza virus vaccine based on altered viral M2/M42 ion channel expression that protects against highly pathogenic virus challenge. |
| IP Reference | |
| Protection | Patent granted |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | This collaboration led to further joined funding by the BBSRC and NSF [BB/V011286/1]. |
| Title | IMMUNOGENIC OMPOSITIONS CONTAINING ESCHERICHIA COLI H7 FLAGELLA AND METHODS OF USE THEREOF |
| Description | Immunogenic compositions containing Escherichia coli O157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli O157:H7 to cells within the animal. |
| IP Reference | WO2009050474 |
| Protection | Patent granted |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | A commercial partner (Roslin Technologies Ltd) has now licensed the patents associated with this potential cattle vaccine and the wider possibilities for the mucosal adjutancy of H7 flagella. They are currently supporting manufacture of the antigens as well as some safety and efficacy testing towards a trial of the vaccine in a commercial feedlot. |
| Title | Vaccine effectiveness in the field - an interactive R shiny modelling app |
| Description | This is an interactive R Shiny app for the model dynamics in the prophylactic vaccination under different replacement rates and different vaccine properties. Further details of the model and the interactive app can be found at this link, which is situated at the University of Edinburgh wiki-server, and outlines the components underlying vaccine effectiveness in the field, and their individual and interactive effects (https://doi.org/10.1371/journal.pone.0220738.s001). For a detail description of the procedure please see this article (DOI: https://doi.org/10.1371/journal.pone.0220738). |
| Type Of Technology | Webtool/Application |
| Year Produced | 2019 |
| Open Source License? | Yes |
| Impact | Used internally as teaching tool |
| URL | https://zenodo.org/record/3696667#.XmFF26j7Sbg |
| Description | 'Science Insights 2022' - Research presentation |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Science Insights is a work placement programme for high school pupils about to enter S6 (final year at high school). Backgrounds and insights around animal biotechnology were presented to the pupils and inspired engaging discussions. |
| Year(s) Of Engagement Activity | 2022 |
| Description | 'Science Insights' "Host responses underlying immunity" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Developed and run through EBSOC at Easter Bush Campus, Science Insights is on-going work experience programme designed to give 5th year high school pupils a real insight into the work and life of research scientists. Science taster sessions delivered under "Host responses underlying immunity" included "The Use of flow cytometry to characterise macrophage subsets in mouse tissue" "Mouse model of inflammatory bowel disease" "Parasite burden in alapacas - faecal worm counts" |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ed.ac.uk/medicine-vet-medicine/outreach/science-insights |
| Description | Activity at Roslin Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Heather Mathie in my research group designed an activity relating to the immune response and vaccines. This was to explain the value of vaccines for animals, and the studies we are undertaking to understand what comprises a protective immune response and how we might design new vaccines using this information. |
| Year(s) Of Engagement Activity | 2018 |
| Description | American Society for Virology Meeting - Presenation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation at the Amercian Society for Virology Meeting on "RNAi screening of RSV combined with meta-analysis reveals common roles for ADAM family proteins in virus replication" |
| Year(s) Of Engagement Activity | 2022 |
| Description | American Society for Virology Meeting - Presenation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation at the American Society for Virology Meeting on "Direct lysis RT-qPCR-based RNAi screen of SARS-CoV-2 production reveals host genes involved in the entire replication cycle". |
| Year(s) Of Engagement Activity | 2022 |
| Description | Annual Roslin Institute Open Doors Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual Roslin Institute Open Doors day was held on 14 October 2017 and was attended by 491 people. It involved 81 members of staff and students and showcased a wide range of research arising from BBSRC strategic investment, including (but not limited to), food safety, influenza, genetic improvement, DNA, imaging and the ethical treatment of animals in research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Annual Roslin Institute Open Doors Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual Roslin Institute Open Doors day was held on 14 October 2017 and was attended by 491 people. It involved 81 members of staff and students and showcased a wide range of research arising from BBSRC strategic investment, including (but not limited to), food safety, influenza, genetic improvement, DNA, imaging and the ethical treatment of animals in research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Avian Pathogenesis Meeting, Shanghai Veterinary Research Institute. "Generation of genome wide CRISPR Cas9 libraries for pig and chicken" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Avian Pathogenesis Meeting was organised to provide an opportunity for interaction and collaboration with veterinary scientists from China. I presented our work on genome-wide CRISPR/cas9 libraries for pig and chicken and ISG libraries for pig and chicken. We highlighted our new capability to perform high throughput systematic functional screens in livestock species. Potential collaborations and sharing of resources were discussed and are currently being acted on. |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC Countryfile film related to the work of the Centre for Tropical Livestock Genetics & Health at Roslin |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Bill Gates was interviewed by BBC Countryfile on 26 January 2018 in relation to work funded by the Gates Foundation involving Roslin Institute scientists towards the genetic improvement of farmed animals in low- and middle-income countries. The programme aired on 11 February 2018 and reached an estimated audience in excess of 5 million. The interview took place on the same day as the launch of the Global Academy of Agriculture & Food Security, which was attended by the Secretary of State for the Department for International Development the Rt Hon Penny Mordaunt (see separate activity) and generated significant press interest, featuring on BBC Scotland news. Particular emphasis was placed on the work of Roslin scientists to understand the genetic make-up of African diary cattle and chickens and to understand how this relates to performance traits in order to guide breeding decisions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC One Scotland COVID Update |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 10 appearances. |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | BBC Radio Scotland - Debate night extra |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 10 appearances |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | BBC Radio Scotland - Mornings Programme |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 20 appearances. |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | BBC Radio Scotland Lunchtime Live |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 15 appearances |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | BBC Radio Wales |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. 3 appearances |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | BBC Three Counties Radio |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 5 engagements. |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | BBSRC workshop & briefing at Science Media Centre plus associated news coverage |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | BBSRC workshop & briefing at Science Media Centre plus associated news coverage in The Guardian, Sky, The Telegraph, Hereford Times, Yahoo, Daily Mail, The Sun, Mail on Sunday, The Times, Aol, BT, Sky News, The Irish Sun, Scotsman Food and Drink, The Herald, The National, Breaking News.ie, The Irish News, Irish Examiner, Classic FM, Eagle Radio, Spirit FM, Capital FM, Heart, Gazette and Herald, Farm Week, Gazette, Evening Express, Border Telegraph, Times and Star, TalkTalk, Wales Farmer, Evening Telegraph, South West Farmer |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/livestock-research-focus-at-international-event |
| Description | BBSRC-DBT Livestock Health and Disease workshop (2012), Delhi, India in Feb 2012 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | BBSRC-DBT Livestock Health and Disease workshop (2012), Delhi, India in Feb 2012 no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2012 |
| Description | British society for Immunology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation at the British Society for Immunology, Dec 2017. Poster entitled: Precision cut lung slices: A platform for examining host-pathogen interactions in an avian model. Authors on the posters: Bryson K, Esposito M., Lamont S., Stevens M., McLaughlan G. and Vervelde L. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Campus Open Day- Midlothian Science Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Roslin Institute and Easter Bush Campus Open Day was an event undertaken within the Midlothian Science Festivals. Hands on public activities lead by scientists under "Host responses underlying immunity" included Science is for Everyone |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre |
| Description | Cattle immune cells could help treat disease |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | report around 'Cattle immune cells could help treat disease' appearing in Agriland, The Financial |
| Year(s) Of Engagement Activity | 2021 |
| Description | Changing World Conversations - The future of food. Live online panel session plus prerecorded researcher interviews. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Changing World Conversations - The future of food. Live online panel session plus prerecorded researcher interviews. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Cited in print or broadcasting media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / News on COVID-19 pandemic. Total number of article citations from Dec 2020 - 11/03/22: 1,145 Total reach: 16,973,830,000 Online news mentions: 891 Broadcast news mentions: 145 Print mentions: 105 Blogs: 4 Breakdown by location: UK: 1,039 US: 31 New Zealand: 8 Ireland: 7 Canada: 6 |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | Conference talk on PRRS infection dynamics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A. Wilson presented the talk "Is PRRSV viremia rebound preventable? Evidence from a data-supported mechanistic model of the immune response" at the Conference for research workers in Animal Diseases (CRWAD) in Chicago 2018. The talk sparked intense discussions about the occurrence and role of viremia rebound in infectious diseases. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://crwad.org/2018-crwad-conference/ |
| Description | Coordinated meeting of the international 'Functional Annotation of All Salmonid Genomes' initiative |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This meeting was attended by 30 salmonid biologists linked to the international FAASG initiative (https://www.faasg.org/). Key discussions were held on the future of the initiative, its links to UK infrastructure (EMBL-EBI) and future funding priorities, influencing funders in attendence (Norwegian Research Council and Genome Canada) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://icisb.org/faasg-meeting/ |
| Description | DNA Profiling: The Great Escape |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A full day workshop to develop pupils' practical lab skills and knowledge through working in our laboratory. They will prepare the solutions and agarose gels needed to carry out gel electrophoresis, supported by scientists and technicians working at the University. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | EBSOC Led Engagement Activities- Talks/Discussions |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The Easter Bush Science Outreach Centre (EBSOC) which opened in January 2018 is the first of its kind in Scotland. EBSOC is a unique, purpose-built laboratory space where visitors, including primary and secondary pupils and their teachers, engage with real-life science. Supported by scientists from "Host responses underlying immunity", EBSOC's schools workshops enable pupils to meet scientists from The Roslin Institute. As well as supporting scientist-lead workshops both to National and International audiences, scientists undertaking research within "Host responses underlying immunity" undertake discussions and talks within these activities on research undertaken within this theme the control of diseases between humans and animals. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre |
| Description | EBSOC Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Regular communications from EBSOC about our resources, activities and workshops are communicated to all contacts. These contacts are working in or closely with Scottish education settings. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | EBSOC Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Regular communications from EBSOC about our resources, activities and workshops are communicated to all contacts. These contacts are working in or closely with Scottish education settings. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Edinburgh India Institute, Inaugural conference on 15-16 May 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Gave a short talk about avian influenza BBSRC-DBT project and how it came about, joint talk with our India collaborators. Edinburgh India Institute, Inaugural conference on 15-16 May 2014. John McIntyre Conference Centre, Edinburgh. Conference theme: Innovative Engagement for Sustainable Development: the Edinburgh-India Story. |
| Year(s) Of Engagement Activity | 2014 |
| Description | FarmingUK - MDV |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Media article in FarmingUK led to increased awareness of publication on resistance to Marek's Disease Virus |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.farminguk.com/news/gene-findings-could-help-treat-costly-poultry-virus_56725.html |
| Description | Feedstuffs - MDV |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Media article in Feedstuffs led to increased awareness of publication on resistance to Marek's Disease Virus |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.feedstuffs.com/nutrition-health/gene-findings-suggest-mareks-disease-treatment-targets |
| Description | Flu talk - journalists |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Presentation of our work on avian flu to a selection of Indian and Japanese journalists. Government representatives were also present. Interest in future Scottish/Indian proposals was shown. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Food and Farming - MDV |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Media article in Food and Farming led to increased awareness of publication on resistance to Marek's Disease Virus |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.foodandfarmingfutures.co.uk/Library/content/Detail.aspx?ctID=ZWVhNzBlY2QtZWJjNi00YWZiLWE... |
| Description | Gel Electrophoresis Wall Tank |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A classroom resource developed by EBSOC to support teachers to explore how gel electrophoresis works with their pupils. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Gel Electrophoresis Wall Tank |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A classroom resource developed by EBSOC to support teachers to explore how gel electrophoresis works with their pupils. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Gel Electrophoresis in Action |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This video has been designed to support Higher Biology and Higher Human Biology learners to develop their knowledge and understanding of gel electrophoresis. |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre/teacher-zone/home-classroom-educatio... |
| Description | Genomics of fishes from aquaculture to evolution - Presentation at Launch Event for "Genomics at Edinburgh" network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited talk at University of Edinburgh launch event for 'Genomics at Edinburgh'. This was an online event, with ~200 individuals in attendance representing the broad base of genomics researchers within the University. There were several follow up questions, and the talk achieved knowledge exchange on aquaculture genomics research at the Roslin Institute, and there were several follow up questions and additional off-line discussions. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Great Science Share (online) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In 2018 the Easter Bush Science Outreach Centre became the Great Science Share's Edinburgh Satellite and in 2020 the Roslin Institute's Education & Engagement Officer (Jayne Quoiani) became Regional Champion for Scotland. Supported by scientists and technicians from The Roslin Institute we offered Edinburgh and Midlothian participating schools our Big Balloon Blow Up Investigation kits, which included all the experimental materials, teacher CPD session, classroom resources and the creation of a celebration video for the pupils doing their investigations in school which was shared on the day in June 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Great Science Share for Schools in Scotland Webinar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In partnership with the Scottish Schools Research Center (SSERC) we will run a national information session for Scottish primary school practioners on the 2022 Great Science Share for Schools Campaign. Our Education & Engagement Officer is a Regional Champion of this global programme. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Great Science Share | Penicuik Beeslack Cluster Project |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In 2018 the Easter Bush Science Outreach Centre became the Great Science Share's Edinburgh Satellite and in 2020 the Roslin Institute's Education & Engagement Officer (Jayne Quoiani) became Regional Champion for Scotland. Supported by scientists and technicians from The Roslin Institute we offerred our local participating schools to use our Science @Home Investigation packs and submit photos and vides of their pupils at home doing the investigations (first lockdown) so that we could create a video to be shared on the Great Science Share day in June 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre/teacher-zone/great-science-share-202... |
| Description | Host and convenor of the joint SAPHIR and VET-VAC workshop, Roslin, UK, May 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The Roslin Institute hosted the 2nd International Veterinary Vaccinology workshop with the goal to provide scientists and practicioners integrated and up-to-date knowledge on the challenges facing the development of effective veterinary vaccines |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.vetvaccnet.ac.uk/events/european-veterinary-vaccinology-workshop-2018 |
| Description | How gene editing can contribute to the future of food production, Future of Food and Agriculture, New Scientist Live |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A panel discussion and interaction through questions of the public on the future of genome-edited animals in the food sector and in the worldwide development of agriculture. |
| Year(s) Of Engagement Activity | 2020 |
| Description | ISAG talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk title: Mapping QTLs affecting Marek's disease by selective DNA pooling in eight lines across 15 generations |
| Year(s) Of Engagement Activity | 2017 |
| Description | ITV Borders - News Pieces on COVID-19 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 15 appearances |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | Immunology expertise request for Independent newspaper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Provide response to media requests for scientific expertise/opinion on study describing effects of COVID-19 on the gut microbiome. This was picked up by several publishers. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.independent.co.uk/news/health/gut-bacteria-covid-19-severity-study-b1785870.html |
| Description | Instagram Live: Covid-19 Vaccine Q&As |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 15 minute online Q&A on Covid-19 vaccines with Neil Mabbott, available online via Instagram stories |
| Year(s) Of Engagement Activity | 2020 |
| Description | Institute of Animal Pathogology, University of Bern. "Bringing high throughput approaches to livestock species". Invited talk. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Was invited to Bern to present on our work on developing CRISPR/Cas9 and ISG libraries for pig and chicken. Collaborations and sharing of resources were discussed and are being put into action. Additionally the visit was organised to increase links with an institute with aligned scientific interests. |
| Year(s) Of Engagement Activity | 2018 |
| Description | International PRRSV symposium - South Korea |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 60-100 practitioners met to learn about advances in PRRSV including control and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Interview for National news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Request from The National newspaper to give immunology expert opinion on success of Pfizer COVID-19 vaccine |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thenational.scot/news/18915786.pfizer-covid-vaccine-triumph-science---concrete-way-crisi... |
| Description | Interview for the i newspaper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Provided immunology expertise on study suggesting that men are twice as likely to die of COVID-19 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://inews.co.uk/news/uk/covid-deaths-working-age-twice-likely-die-coronavirus-data-experts-warni... |
| Description | Interview for the i newspaper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Provided immunology expertise to describe why vaccination can cause minor side effects. Used to help dispel rumours that COVID-19 vaccination causes serious side-effects |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://inews.co.uk/news/health/covid-vaccine-side-effects-coronavirus-jab-minor-reactions-symptoms-... |
| Description | Introduction to the Research of the Roslin Institute - Royal Society of Biology Scottish Branch Annual Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Stevens provided an overview of the research of The Roslin Institute to members of the public and the Royal Society of Biology, who convened for the annual symposium of the RSB Scottish Branch on 14 October 2017 at Roslin. The event coincided with the annual Roslin 'Open Doors' day and featured BBSRC-funded research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Departmental Seminar: "All things fish: genomic perspectives from food security to evolution". |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Departmental Seminar: Trinity College Dublin (Smurfit Institute of Genetics). 12th Jan 2024. Hosted by Prof. Aoife McLysaght |
| Year(s) Of Engagement Activity | 2024 |
| Description | Invited Lecture: Functional annotation of fish genomes: towards precision aquaculture breeding founded on biological understanding |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited online lecture -'Functional annotation of fish genomes: towards precision aquaculture breeding founded on biological understanding' at the 1st aquaculture seed industry professional forum. 30th China Beijing seed Industry Conference. 11th Sept 2023. Provided audience with overview of latest status of genomic technologies for aquaculture breeding. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited Speaker - 33rd ENGL Plenary Meeting - European Commission |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation on novel breeding technologies in animals and how advances can help us face global challenges. Attendees from the European Commission, Ministries from European member states, researchers and the overall audience showed a keen interest in the advances recently made in the animal biotechnology sectors. There is a clear interest in regulating and thereby opening the pathway to integration of novel breeding technologies from member states. The discussion was very engaged and has since lead to more specific interactions with the ministries of individual member states. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Webinar: 'Harnessing single cell transcriptomics to understand and improve salmon performance and health'. Webinar: Understanding and improving salmon performance. Blue Economy Cooperative Research Centre. 21st June 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited webinar: 'Harnessing single cell transcriptomics to understand and improve salmon performance and health'. Webinar: Understanding and improving salmon performance. Blue Economy Cooperative Research Centre. 21st June 2023. Provided an overview of the transformative potential of single cell transcriptomic technologies to understanding and improve the welfare, health and performance of farmed salmon. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://blueeconomycrc.com.au/webinar-understanding-and-improving-salmon-performance/ |
| Description | Invited lecture at Boehringer Ingelheim Animal Health Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | PI Prof Vervelde gave an invited lecture at BI-AH in Hannover Germany. BI colleagues from other offices all over the EU and USA participated thorugh WebEx connection. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited lecture at MSD-Animal Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited lecture at MSD-Animal Health in Boxmeer the Netherlands, with WebEx connection to all other location o MSD -AH around the world. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited lecture at the annual BSI meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave an invited lecture in the session Immune surveillance and lymphoid tissue architecture at the annual BSI congress in Liverpool. It sparked questions and request fo further info and collaboration. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bsicongress.com/sessionspeakers |
| Description | Invited participation - 2nd Albrecht Mueller ARRIGE Seminar |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Important discussion around the Social and Ethical Implications of Genome Editing in Animals. Particularly impactful in the context of the Genetic Technology (Precision Breeding) bill in the UK and linked responses from interested parties. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.arrige.org/portfolio/2nd-albrecht-muller-arrige-seminar/ |
| Description | Invited presentation - 4th International Workshop on Regulatory Approaches for Agricultural Applications of Animal Biotechnologies |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Workshop discussions on international trade and regulation of novel breeding technologies in animal biotechnology. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited speaker - Avian Genetics and Immunity Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research on Avian Genetics and Immunity (RAGI) has been established to strengthen global partnerships and links between academic researchers, students and the poultry professionals working on the genetics of avian immunity. The purpose of the symposium was to provide a forum for discussion and exchange of ideas around the single theme of exploiting available opportunities in ultimately dealing emerging and existing infectious avian diseases in poultry production systems and to safeguard food supplies and human health. The purpose of KW talk was to overview the current situation in industry for breeding for disease resistance and introduce the NARF. The overview of NARF included a review of facilities, lines available and current work being carried out using NARF avian lines. The presentation stimulated significant discussion. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://geneticsandimmunity.com/ |
| Description | Invited speaker at the In vitro host-pathogen workshop 2018, Moredun Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the In vitro host-pathogen workshop 2018, Moredun Institute. Talk focused on 3Rs solutions to study host pathogen interaction in poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited talk European Veterinary Vaccinology Workshop 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on career opportunities in academia for young scientists |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=hTujbImUCcI |
| Description | Invited talk at International Veterinary Immunology Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited presentation at the International Veterinary Immunology Symposium on natural killer cells and vaccine responses. Audience of professional colleagues, postgraduate students and industry representatives |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at International workshop Functional annotation of the Atlantic salmon genome, translation to improved health and performance in aquaculture. 'Advancing aquaculture by genome functional annotation: Memorial University, Canada. Aug 26-27th 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Gave an invited talk at International workshop Functional annotation of the Atlantic salmon genome, translation to improved health and performance in aquaculture. 'Advancing aquaculture by genome functional annotation: Memorial University, Canada. Aug 26-27th 2019. The outcomes were an increased mutual understanding of research and collaborative activity with international collaborating scientists. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | North American PRRS symposium. Chicago, USA, Dec 2017. Novel insights about host response to PRRS from data driven mathematical models. Invited talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited talk at the Swiss Virology Meeting 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk presenting an overview or our research activities from genome editing, primary cell models (including organoids, iPSCs, primary cells, complex cell models) with a primary focus on genome editing. |
| Year(s) Of Engagement Activity | 2023 |
| URL | http://swissvirology.ch/ |
| Description | Invited talk: "AQUA-FAANG: decoding genome function to enhance genotype-to-phenotype prediction in farmed finfish" EAAP Session - EuroFAANG: Genotype-to-phenotype research across Europe and beyond. 31.08.2023, Lyon, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited talk: "AQUA-FAANG: decoding genome function to enhance genotype-to-phenotype prediction in farmed finfish" EAAP Session - EuroFAANG: Genotype-to-phenotype research across Europe and beyond. 31.08.2023, Lyon, France. Part of a session that included an industry panel session -"How European animal breeding sector can use EuroFAANG Research Infrastructure and knowledge developed so far" Opportunities and barriers for uptaking the results, with 4 panellists coming from industry. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.gene-switch.eu/uploads/1/2/6/6/126678735/agenda_-_eurofaang_eaap_2025.pdf |
| Description | Joint organiser of the Gordon Lawson Memorial Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We organised the first International conference on Lawsonia intracellularis in association with Boehringer Ingelheim. The conference was in memory of Dr Gordon Lawson to honour his pioneering work on the important pig pathogen that bears his name. ~100 people attended, mainly veterinary practitioners dealing with the disease and companies trying to detect and prevent it. The symposium was held over two days at the Roslin Institute and RDSVS |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/scientific-events/archive/gordon-lawson-memorial-symposium |
| Description | LAB CAMP - Proteins & Antibodies | ELISA Masterclass: Flu Fighters |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | A full day, hands-on polymerase chain reaction (PCR) masterclass for Advanced Higher Biology pupils (school or college). Using your own DNA, you will use cutting-edge equipment to carry out the modern laboratory techniques of DNA extraction, PCR, restriction enzyme digestion and DNA gel electrophoresis |
| Year(s) Of Engagement Activity | 2022 |
| Description | Lab Techniques: Gel Electrophoresis in Action |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This video has been designed to support Higher Biology and Higher Human Biology learners to develop their knowledge and understanding of PCR. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Lab Techniques: Gel Electrophoresis in Action |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This video has been designed to support Higher Biology and Higher Human Biology learners to develop their knowledge and understanding of PCR. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Lab Techniques: PCR in Action |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This video has been designed to support Higher Biology and Higher Human Biology learners to develop their knowledge and understanding of gel electrophoresis. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Lab Techniques: PCR in Action |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This video has been designed to support Higher Biology and Higher Human Biology learners to develop their knowledge and understanding of gel electrophoresis. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Lead Organiser of the BBSRC Cross Institute workshop on "The Future Role of Livestock in Food Production |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | In this 2 day workshop, funded by the BBSRC, scientists and industry experts examined the need and scope for change in the livestock sector in response to increasing societal and environmental challenges. The outcome of the workshop resulted in a recommendation document sent to BBSRC that outlined the status quo and research and funding needs for future livestock research. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/future-of-livestock-production-in-the-spotlight |
| Description | Lead coordinator of the fourth International Conference on the Integrative Biology of Salmonids (https://icisb.org/). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The fourth International Conference on Integrative Salmonid Biology (ICISB 2019), followed on from previous meetings in 2012 (Oslo, Norway), 2014 (Vancouver, Canada) and 2016 (Puerto Varas, Chile). The ICISB meetings have been core funded and organized by the International Cooperation to Sequence the Atlantic Salmon Genome (ICSASG), a trilateral effort between Canada, Chile and Norway. The theme of ICISB 2019 was'Beyond the genome: taking leaps forward in salmonid biology' to reflect the recent staggering progress in genomic resource development and exploitation since the Atlantic salmon reference genome was published in 2016. There was an audience of ~200, which represented a mixture of researchers from Professors leading in the field, to undergraduate students. Many international collaborations and opportunities for further research, funding and meetings were explored with a range of stakeholders, including funders, media and industry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://icisb.org/ |
| Description | Lothian Agricultural Discussion Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Visit by the Lothian Agricultural Discussion group to the Large Animal Research and Imaging Facility. Primarily from a farming or veterinarian background the audience was engaged in listening to the talks and asking further questions around biotechnology and animal research. |
| Year(s) Of Engagement Activity | 2023 |
| Description | MRCVS - MDV |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Media article in MRCVS led to increased awareness of publication on resistance to Marek's Disease Virus |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://mrcvs.co.uk/en/news/19721/DNA-discovery-could-help-treat-Marek's-disease |
| Description | Media attention after 3D chicken gut model publication initiated by Prof L Vervelde |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release after publication of the novel chicken 3D gut model https://www.poultryworld.net/health-nutrition/3d-gut-models-from-stem-cells-to-support-studies/ https://www.farminguk.com/news/-inside-out-mini-guts-aid-studies-into-poultry-health_57927.html https://vetcommunity.com/vc/newsitem/?story=20327 https://www.thepoultrysite.com/articles/poultry-scientists-develop-inside-out-approach-to-health-and-disease-research https://www.wattagnet.com/articles/42652-mini-gut-model-aids-chicken-infection-immunity-research?v=preview |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.wattagnet.com/articles/42652-mini-gut-model-aids-chicken-infection-immunity-research?v=p... |
| Description | Media interest in flu transcriptomics paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media article in MRCVS regarding transcriptomic study of host response to avian flu in different bird species (doi.org/10.3389/fcimb.2023.1067993) |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://mrcvs.co.uk/en/news/22354/Study-finds-clues-to-avian-flu-resistance |
| Description | Media interest in flu transcriptomics paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Media article in vn online regarding transcriptomic study of host response to avian flu in different bird species (doi.org/10.3389/fcimb.2023.1067993) |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://vnonline.co.uk/vn/news/22354/Study-finds-clues-to-avian-flu-resistance |
| Description | Media interview for Understanding Animal Research |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the beneficial use of our mouse experiments from our study describing the effects of aging and the microbiota on Paneth cells and M cells to the blog Understanding Animal Research |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.understandinganimalresearch.org.uk/index.php?cID=1977 |
| Description | Meet a Roslin Scientist |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | In response to the global pandemic, the Roslin PE team created an online schools engagement programme to replace the hands-on sesssions normally delivered at EBSOC. Meet a Roslin Scientist is an online, interactive event for school pupils and FE college students to get the opportunity to learn about Roslin research and meet with one of our researchers or technical staff. These sessions give young learners a unique opportunity to learn about some current science happening here in Scotland, hear about different career paths and give them the opportunity to ask their own questions. Sessions like this can increase pupils´ curiosity in STEM, help raise awareness of STEM careers and support pupils to reflect on their own science-related skills. So far sessions have involved postdocs, core scientists and technical staff from across the Institute. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Meet a Roslin Scientist - various scientists over 2021 and early 2022 (online) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | In response to the global pandemic, the Roslin PE team created an online schools engagement programme to replace the hands-on sesssions normally delivered at EBSOC. Meet a Roslin Scientist is an online, interactive event for school pupils and FE college students to get the opportunity to learn about Roslin research and meet with one of our researchers or technical staff. These sessions give young learners a unique opportunity to learn about some current science happening here in Scotland, hear about different career paths and give them the opportunity to ask their own questions. Sessions like this can increase pupils´ curiosity in STEM, help raise awareness of STEM careers and support pupils to reflect on their own science-related skills. In the 2021/22 reporting period we ran 11 sessions which involved postdocs, core scientists and technical staff from across the Institute. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Membership of a guidance committee on PCV2 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Expert Group on PCV2 for DISCONTOOLS FP 7 project, funded by DG Research |
| Year(s) Of Engagement Activity | 2006,2008,2009,2011,2013,2015,2017,2019 |
| Description | Mercks Digital Journal |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online publication: De Castro AMMG, Opriessnig T. PCV2 genotypes and cross protection. Mercks digital magazine. 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Midlothian Science Festival Schools Programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In response to the global pandemic the Roslin PE team created an online Midlothian Science Festival Schools Programme. In addition to coordinating the overall programme with partners from across the University of Edinburgh and wider STEM organisations, we also ran "Meet our Scientists" sessions for pupils aged 10 to 14 years old. These online, interactive events for Midlothian school pupils gave them the opportunity to learn about Roslin research and meet with one of our researchers or technical staff. These sessions give young learners a unique opportunity to learn about some current science happening here in Scotland, hear about different career paths and give them the opportunity to ask their own questions. Sessions like this can increase pupils´ curiosity in STEM, help raise awareness of STEM careers and support pupils to reflect on their own science-related skills. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre/teacher-zone/msf-schools-programme-2... |
| Description | Midlothian Science Festival Schools Programme(online) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In response to the global pandemic the Roslin PE team created an online Midlothian Science Festival Schools Programme. In addition to coordinating the overall programme with partners from across the University of Edinburgh and wider STEM organisations, we also ran "Meet our Scientists" sessions for pupils aged 10 to 14 years old. These online, interactive events for Midlothian school pupils gave them the opportunity to learn about Roslin research and meet with one of our researchers or technical staff. These sessions give young learners a unique opportunity to learn about some current science happening here in Scotland, hear about different career paths and give them the opportunity to ask their own questions. Sessions like this can increase pupils´ curiosity in STEM, help raise awareness of STEM careers and support pupils to reflect on their own science-related skills. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Munster flu meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 5th international influenza meeting. IFITM talk. Munster, Germany. Sep 2016 |
| Year(s) Of Engagement Activity | 2016 |
| Description | Nuffield Research Placement | Nicholson Institute - online |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Nuffield Research Placement | Nicholson Institute - online |
| Year(s) Of Engagement Activity | 2021 |
| Description | One Health Poultry Hub programme of interdisciplinary learning; An introduction to avian immunology and vaccinology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The audience for this webinar series is drawn from the Poultry Hub network and includes vets, bioscientists and infectious disease experts (and PhD students) and also social scientists and economists. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.onehealthpoultry.org/ |
| Description | Online Workshop: Single cell transcriptomics: unlocking innovation in aquaculture research - Friday 18th June 2021, 1000-1300 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | This was an online workshop organized by my lab at the Roslin Institute. There were approximately 100 in the audience, largely representing aquaculture researchers, mainly from academic and research organizations from Europe, but also some multi-national companies. The workshop included multiple talks from experts in single cell transcriptomics and sessions about how this transformative technology can be uptaken for impact in aquaculture research and innovation. There was extensive discussion at the workshop and offline afterwards with several international groups. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://genetics.org.uk/events/single-cell-transcriptomics-unlocking-innovation-in-aquaculture-resea... |
| Description | Online talks for Penicuik and District U3A group on the gut microbiome and immunity; and alternatives to antibiotics |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Online talks for Penicuik and District U3A group on the gut microbiome and immunity; and alternatives to antibiotics |
| Year(s) Of Engagement Activity | 2021 |
| Description | Open lecture on African trypanosomes in cattle to Royal Society of Biology Scottish Branch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Liam provided an overview of his research on African trypanosomes in cattle to members of the public and the Royal Society of Biology, who convened for the annual symposium of the RSB Scottish Branch on 14 October 2017 at Roslin. The event coincided with the annual Roslin 'Open Doors' day and featured BBSRC-funded research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Opening a Can of Worms - CLPL (Career Long Professional Learning) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Getting Hands-on in your Classroom with the Scientific Method | Primary Teacher CLPL Workshop |
| Year(s) Of Engagement Activity | 2022 |
| Description | Opinion article for The Conversation |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to write an opinion article on the whether young people should be offered COVID-19 booster vaccines |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://theconversation.com/five-reasons-why-young-people-should-get-a-covid-booster-vaccine-189411 |
| Description | Opinion article for The Conversation |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to write an opinion article on the effectiveness of bivalent COVID-19 vaccines |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://theconversation.com/bivalent-covid-vaccines-have-now-been-in-use-for-a-few-months-heres-how-... |
| Description | Opinion article for The Conversation |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to write an opinion article of the effectiveness of annual COVID-19 vaccine boosters |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://theconversation.com/covid-vaccines-an-annual-booster-like-the-flu-shot-could-be-the-way-forw... |
| Description | Oral presentation at the XVIth Avian Immunology Research Group at the university of Delaware, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Oral presentation by ECR Dr Kate Sutton at the AIRG, entitled Differential Innate Immune Responses of Chicken 3D and 2D Enteroids to Salmonella Typhimurium Infection |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ud-pcs.idloom.events/2022-airg-conference |
| Description | Oral presentation by Dr S Sives at the International Symposium on Avian Viral Respiratory Diseases 2022, Leusden The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | An oral presentation was given to a relevant group of academic researchers and industry representatives from the research field. Following on from the presentations it lead to discussions with peers and industry partners on the significance and suggestions to drive the future direction of this research as well as discussion regarding technology available at Roslin Institute available for collaborations. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://avrdsymposium.com/ |
| Description | Oral presentation by Dr S. Sives at Edinburgh Infectious Diseases Early Career Symposium (online) , 28th October 2021. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A flash oral presentation was given at an online event specifically for early career researchers, the inaugural Edinburgh Infectious Diseases Early Career Research Symposium, October 28th 2021. Early career researchers actively involved in infectious disease research presented a diverse range of research. The audience consisted of postgraduate, post-doctoral and principal scientists from across the University of Edinburgh. The event was designed to enhance collaboration and networking opportunities across diverse research groups and engage with other attendees allowing discussions around future research plans. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ed.ac.uk/edinburgh-infectious-diseases/news/upcoming-events/eid-ecr-symposium |
| Description | Organisation of Workshop on "Genome engineering and wider applications" at the WVPA 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organised a preconference workshop on "Genome engineering and wider applications" for the World Veterinary Poultry Association with talks on "Editing techniques and biobanking", "The transgenic hen bioreactor", "Ethics and consumer acceptance, and "Use of transgenic chickens in disease and vaccine studies". Number of WVPA participants was ~2300. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.wvpa.net/congress.php |
| Description | PAG 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Plant and Animal Genome conference 2018 (San Diego, USA) 'Avian flu: the winners and the losers' - Jan 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | PCR Refresher Secondary Teacher CLPL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | This full day, hands-on CLPL workshop, for secondary school science teachers, will be a technique refresher focused on PCR and gel electrophoresis. |
| Year(s) Of Engagement Activity | 2022 |
| Description | PCR in Action |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | This video has been designed to support Higher Biology and Higher Human Biology learners to develop their knowledge and understanding of PCR. |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre/teacher-zone/home-classroom-educatio... |
| Description | Participated as one of 4 panellists in the Science Media briefing event Can We Have Our Meat and Eat It? - The Future of Meat Production" Science Media Centre London 2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The briefing resulted in a wide media coverage in many regional and national newspapers, including the Guardian, The Sun, The Times etc.: Guardian https://www.theguardian.com/environment/2019/nov/28/gm-could-help-cut-livestock-methane-emissions-say-scientists PA via Hereford Times https://www.herefordtimes.com/news/national/18063917.breeding-help-cattle-become-environmentally-friendly-scientists-say/ Telegraph https://www.telegraph.co.uk/science/2019/11/27/meat-crucial-feeding-planet-going-vegan-not-green-say-scientists/ PA via iNews Clips Sky News https://news.sky.com/story/cattle-may-be-bred-to-grow-faster-and-eat-less-and-could-cut-methane-emissions-by-a-third-11871988 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pipetting Pointillism |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Developed and run through EBSOC at Easter Bush Campus and in local schools. Micropipetting is one of the most common techniques in a biological science laboratory, allowing us to transfer small and precise volumes of liquid. Older participants learned to use laboratory micropipettes by practicing with different volumes, the then used their new skill to create a pointillism style picture with paint. Younger participants used fixed volume pipettes to create their own pointillism picture. While participants are pipetting researchers undertaking research within "The regulation an function of genes and cellular pheotypes in animal systems" had the opportunity to discuss and talk research undertaken within this theme. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Pippetting Pointilism |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Developed and run through EBSOC at Easter Bush Campus and in local schools. Micropipetting is one of the most common techniques in a biological science laboratory, allowing us to transfer small and precise volumes of liquid. Older participants learned to use laboratory micropipettes by practicing with different volumes, the then used their new skill to create a pointillism style picture with paint. Younger participants used fixed volume pipettes to create their own pointillism picture. While participants are pipetting researchers undertaking research within "The regulation an function of genes and cellular pheotypes in animal systems" had the opportunity to discuss and talk research undertaken within this theme. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Plenary talk at BSI Congress 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary talk at British Society for Immunology Congress. Title 'Large Animal Models for Host-Pathogen Interaction Studies and Vaccinology' |
| Year(s) Of Engagement Activity | 2020 |
| Description | Poster Presentation by Dr S Sives at the 7th European Veterinary Immunology Group Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A poster presentation was given at the 7th European Veterinary Immunology workshop, held on-line between 29th - 31st August 2021, this meeting is designed to enhance collaboration and network opportunities between worldwide veterinary immunologists. The audience included post-graduate students, peers and experts within the wider field of veterinary immunology and were actively involved in discussions about the project. It was an excellent opportunity to network with colleagues outside the avian immunology field. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://7theviw.org/index.php?r=site/programme |
| Description | Poster Presentation by K Sutton at the British Society for Immunology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation by ECR Dr Kate Sutton at the BSI in Liverpool presenting a poster entitled: Differential Innate Immune Responses of Chicken 3D and 2D Enteroids to Salmonella Typhimurium Infection. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/thome.csp?pageID=7351&eventID=10&CSPCHD=0000010000001vS... |
| Description | Poster Presentation by K Sutton at the Edinburgh Infectious Diseases Early Career Researcher Symposium 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Over 100 early career scientist and PhD students and group leaders from the University of Edinburgh were in attendance at this online event. The event enhance the networking between immunologist, bacteriologist, and virologist across diverse groups working within the University of Edinburgh. My presentation received a lot of engagement in the form of questions and discussions with attendees. Colleagues at the Roslin Institute also enquired about the work in verbal communications. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ed.ac.uk/edinburgh-infectious-diseases/news/upcoming-events/eid-ecr-symposium |
| Description | Poster Presentation by T Nash at the 7th European Veterinary Immunology Group Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The 7th European Veterinary Immunology Group Meeting was attended online by over 250 veterinary immunologists and representatives of the veterinary industry from around the world. The poster received a lot of engagement from fellow researchers in the form of Q&As |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://7theviw.org/index.php?r=site/programme |
| Description | Poster presentation at Large Animal Research Imaging Facility open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented a poster to groups of individuals who attended an open session/tour of the LARIF facilty at Roslin Institute. This highlighted the work we are doing assessing cellular responses to vaccines. This sparked interest in undergraduate and postgraduate students who were interested in the techniques being used (surgical models and single cell sequencing). |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presentation by Dr S. Sives at British Society for Immunology Congress, 28th November - 1st December 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A poster presentation was given in-person at the British Society for Immunology Congress 2021 in Edinburgh. This annual event is the UK's premier immunology congress, attracting over 1000 attendees with cutting-edge research from leading UK and international researchers. The event was designed to enhance collaboration and networking opportunities across research groups working across the breath of immunology. During the poster session there was a lot of engagement with attendees. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/titem.csp?pageID=5087&eventID=8 |
| Description | Poster presentation by E Armstrong at the British Society for Immunology Congress 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Poster presentation by PhD student Emma Armstrong at the annual BSI meeting in Liverpool, entitled The immunological mechanisms of in ovo vaccination. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.immunology.org/events/british-society-immunology-congress-2022 |
| Description | Poster presentation by K Sutton at the British Society for Immunology Congress 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Over 1000 early career scientists, group leaders and industrial representatives from Great Britain were in attendance at this in-person event. The event enhance the networking between immunologists working across diverse group's undertaking research in the UK. My poster received a lot of engagement in the form of questions and discussions with attendees. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/titem.csp?pageID=5087&eventID=8 |
| Description | Poultry Breeders Roundtable |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • Invited speaker at National poultry breeders roundtable meeting (St Louis, USA) - JS May 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation to Edinburgh Farm Animal Vet Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | I was invited to give a presentation on my research to a group of undergraduate students with an interest in bovine diseases. This was to highlight the importance of research in influencing the future of veterinary vaccines and diagnostics, as well as to enthuse them and encourage the students to consider scientific research careers. The talk was well attended, the students asked lots of good questions and some were planning to look for placements within labs for the summer research component of their course. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to the Slovenian ministries of agriculture, economy, and higher education on genome editing in animals |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | An presentation on the use of new breeding technologies in animals to tackle global challenges. Engaged discussion with the participants on how these technologies can be regulated and integrated in international livestock production. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press release on publication describing effects of ageing on human immune system |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A press statement was released describing our study published in the Journal of Allergy and Clinical Immunology on the effects of a drug, losmapimod, in improving immunity in the skin of elderly humans. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/improving-vaccines-elderly-inflammation |
| Description | Press releases JV IBV vaccine |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Press release was written after our publication in Journal of Virology on novel IBV vaccines. The press release was picked up and published by multiple magazines in the veterinary and agriculture field including: front page with photo; Vet Times - https://www.vettimes.co.uk/news/vaccine-shows-promise-against-chicken-disease/ Farming UK - https://www.farminguk.com/news/New-vaccine-could-help-fight-against-major-poultry-disease_50541.html Agriland - https://www.agriland.co.uk/farming-news/vaccine-shows-promise-against-costly-poultry-disease/ Stackyard - http://www.stackyard.com/news/2018/10/vet/06_edinburgh_vaccine.html Global Meat News - https://www.globalmeatnews.com/Article/2018/10/23/Chicken-disease-vaccine-progress Technology Networks - https://www.technologynetworks.com/tn/news/vaccine-shows-promise-against-chicken-disease-310951 Farming Sector - https://www.farmingsector.co.uk/latest-news/livestock/new-vaccine-could-protect-poultry-from-serious-disease/ Medical Xpress- https://medicalxpress.com/news/2018-10-vaccine-widespread-chicken-disease.html News Medical - https://www.news-medical.net/news/20181023/New-vaccine-strategy-shows-promise-to-protect-chickens-against-serious-respiratory-disease.aspx Feed stuff - https://www.feedstuffs.com/nutrition-health/vaccine-shows-promise-against-ibv Science Daily - https://www.sciencedaily.com/releases/2018/10/181023110540.htm Genetic Literacy Project - https://geneticliteracyproject.org/2018/10/25/bronchitis-in-chickens-can-cut-egg-production-70-new-vaccine-may-stem-outbreaks/ |
| Year(s) Of Engagement Activity | 2018 |
| Description | Press reports on PRRSV-resistant pigs |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In connection with the publication of our research paper "Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection" (doi: 10.1128/JVI.00415-18) we published a press package and answered interview request from many broadcasting and media agencies. As a result the following print and broadcast pieces were released: International Broadcast: BBC Scotland, BBC News at Six, BBC News at Ten, BBC World, BBC Sunday Morning Live, BBC Radio 4 Farming Today, BBC Radio Five Live, BBC Radio 4, BBC Radio Scotland, BBC World Service, Guardian Podcast, BBC Radio Shetland, Swiss Radio & TV (SRF), Country Today (Victoria, Australia, Radio), Fiji Broadcasting Corporation, France 24 Print UK: The Daily Telegraph, The Times, The Guardian, Scottish Daily Mail, The i, Scottish Daily Express, The Sun, Scottish Sun, Daily Mirror, Daily Star, Metro, The Herald, Scotsman, Daily Record, Dundee Courier, Edinburgh Evening News, Aberdeen Evening Express, The Week, Press & Journal, Yorkshire Post Online UK BBC Online, Daily Telegraph, Daily Mail, The Times, The Guardian, Daily Mirror, Daily Express, Scotsman, Irish News, Irish Examiner, Shropshire Star, Express & Star, Hastings Observer, Scarborough News, Eastbourne Herald, Shoreham Herald, West Sussex County Times, Yorkshire Evening Post, Glasgow South & Eastwood Extra, Rye & Battle Observer, Crawley Observer, Bognor Regis Observer, Mid Sussex Times, Worthing Herald, Littlehampton Gazette, Bexhill-on-Sea Observer, Portsmouth News, Chichester Observer, Midhurst & Petworth Observer, Dundee Evening Telegraph, Aberdeen Evening Express, Independent Recorder, TDNews, BT.com, BreakingNews.ie, The London Economic, The Weekly Observer, The Scientist, The London Economic, Science Magazine, Earth.Com, Independent Recorder, BT.com, Breakingnews.IE, I4U News, Press & Journal, Livekindly.co, Tech Times, IFLScience, Technology Networks Online / Print International: NTN24 (CST Science, Health & Technology Magazine, Latin Americas), Infosurhoy, The Economic Times (India), First Post (India), Eurasia Review, HealthEuropa, Jstor Daily, Times Of India, St Lucia News Online, Times Now (India), Business Standard (India), CanIndia.com (India), Green Report (Italy), New Kerala.com, Fanpage.It (Italy), Le Monde Veterinaire (France) Veterinary / Science-related press: Agri-Pulse, Veterinary Times, Vet Record, Pig World, Feedstuffs, Laboratory Equipment, GlobalMeatNews.com, Animal Pharm, Ag Daily, Agribusiness Intelligence, Laboratory Equipment, Pig Progress, Pig World, Labiotech.EU, MRCVS, Farmweek, National Hog Farmer, Farming UK, Frontline Genomics, Farmers Weekly, Food Weekly News |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/gene-edited-pigs-resistant-billion-dollar-virus |
| Description | Public lecture - Inaugural Lecture of Professor Tanja Opriessnig |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Professor Opriessnig delivered her Inaugual Lecture on 'From 'circus virus' to mostly commonly used swine vaccine on 24 April 2017, relating to her BBSRC-funded research on porcine viral diseases and strategies to detect and control them. The event was attended by children from local schools, members of the public and students of the University of Edinburgh. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public lecture entitled Confronting the Microbial Menace in Our Food'. Professor Mark Stevens |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The inaugural lecture of Professor Mark Stevens was held on 30 October 2017 on his BBSRC-funded research to identify bacterial and host factors influencing the ability of Salmonella, Campylobacter and E. coli to colonise farm animals and cause disease. It was attended by children from local schools, members of the public, students at The Roslin Institute and wider University of Edinburgh and posted online. |
| Year(s) Of Engagement Activity | 2017,2018 |
| URL | https://media.ed.ac.uk/media/Inaugural+lectureA+Confronting+the+microbial+menace+in+our+food/1_x5k5e... |
| Description | Research Insights: Science after Dolly |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Research Insights podcast on Science after Dolly. Interdisciplinary presentation on genome editing (for PRRSV resistance) and the ethics around it. Sparking a good discussion on regulation, dysregulation, and ethics. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ed.ac.uk/medicine-vet-medicine/news-events/college-events/research-insights/winter-21-22... |
| Description | Roslin flu meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 'Avian flu: the winners and the losers' at Annual influenza meeting, Roslin Nov 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | STV - News pieces |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 20 appearances |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | STV - Scotland Tonight |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview / comments on COVID-19 Pandemic and situation in Scotland, UK and globally. Roughly 15-20 appearances |
| Year(s) Of Engagement Activity | 2020,2021,2022 |
| Description | School Workshop- DNA Profiling: The Great Escape |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | This workshop was developed and run at the Easter Bush Science Outreach Centre where pupils aged 13-18 took part in this hands-on, researcher-supported workshop linking the techniques of DNA extraction and gel electrophoresis to research on animal behaviour. Participants gained an insight into real-life research and a chance to meet scientists as part of the session and reported an increased interest in science after the session. |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre |
| Description | School Workshop- ELISA- Flu Fighters |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | This workshop was run three times at the Easter Bush Science Outreach Centre to pupils studying Advanced Higher Biology attended this hands-on, researcher-supported workshop, which is based around an ELISA as well as other laboratory techniques from the curriculum, with a research-linked storyline about flu infection in wild birds and chickens. Pupils and teachers reported an improved understanding of the techniques used, after taking part in the workshop as well as an increased interest in immunology and infectious diseases after meeting researchers working in these areas. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ed.ac.uk/easter-bush-campus/science-outreach-centre |
| Description | School outreach visit for International Women and Girls in Science Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | School outreach visit for International Women and Girls in Science Day |
| Year(s) Of Engagement Activity | 2022 |
| Description | Science @Home- Marvellous Mixtures |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This Science @Home investigation (designed for families to use with young learners aged 9-14) is used to explore the question "Can I separate my leafy mixture?". The investigation builds confidence in using the scientific method and reveals Roslin's research using chromatography to analyse metabolites (Proteomics & Metabolomics facility, Kurian/Wishart) |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Science @Home- Marvellous Mixtures |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This Science @Home investigation (designed for families to use with young learners aged 9-14) is used to explore the question "Can I separate my leafy mixture?". The investigation builds confidence in using the scientific method and reveals Roslin's research using chromatography to analyse metabolites (Proteomics & Metabolomics facility, Kurian/Wishart). For significant outcome/impact, in addition to plans made for future related activity, the audience also reported a change in view, opinions and behaviours |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Science @Home- Wonder with Worms |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This Science @Home investigation (designed for families to use with young learners aged 9-14) is used to explore the question"Do worms prefer wet or dry places?". The investigation builds confidence in using the scientific method and reveals Roslin's research on animal welfare and the application of the 3Rs (Meddle/Lawrence). For significant outcomes/impact, in addition to plans being made for future related activity, the audience reported a change in views, opinions or behaviours. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Science Insights 2021: Webinar 1: Where Biology can take you |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Science Insights 2021: Webinar 1: Where Biology can take you |
| Year(s) Of Engagement Activity | 2021 |
| Description | Science Insights 2021: Webinar 2: Covid-19 research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Science Insights 2021: Webinar 2: Covid-19 research |
| Year(s) Of Engagement Activity | 2021 |
| Description | Science Insights Information sessions |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Science insights information sessions around Animals in Research, Research Taster Sessions, Research, Meet the Students and a tour of our Large Animal Research and Imaging Facility |
| Year(s) Of Engagement Activity | 2022 |
| Description | Science Insights Online work experience programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | A week-long online work experience programme for 60 penultimate year high school pupils, exploring research and work in biological, biomedical and animal sciences, with contributions from research staff and students from the Roslin Institute and across the College of Medicine and Veterinary Medicine. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Science Insights Programme for S5 school pupils |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We ran our Science Insights work experience programme for local school pupils on 24-28 July 2017. 38 S5 pupils attended, 20 of whom worked in the Roslin Institute for 2 days alongside BBSRC-supported researchers from this ISP, including our core-funded staff scientists. All 38 students also had a tour of the Langhill farm and attended a presentation and debate about the use of animals in research. Students also had the opportunity to discuss career paths and what it is like to work as a research scientist. Specifically Jayne Hope and Carly Hamilton presented a short talk and activity related to our work on Cryptosporidium parvum infection in calves. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Science Insights work experience for S5 school pupils |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We ran our Science Insights work experience programme for local school pupils on 24-28 July 2017. 38 S5 pupils attended, 20 of whom worked in the Roslin Institute for 2 days alongside BBSRC-supported researchers from this ISP, including our core-funded staff scientists. All 38 students also had a tour of the Langhill farm and attended a presentation and debate about the use of animals in research. Students also had the opportunity to discuss career paths and what it is like to work as a research scientist. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ed.ac.uk/roslin/working/opportunities/young-people/science-insights |
| Description | Scotsman - Coronavirus myths debunked |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Coronavirus myths debunked: Article interview on popular facebook myths on COVID-19. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.scotsman.com/health/coronavirus/coronavirus-myths-debunked-popular-covid-19-conspiracies... |
| Description | Speaker at an International Conference on One Health Antimicrobial Resistance - Leiden |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented a talk on 'alternative approaches to tackling antimicrobial resistance'. A number of scientists at RI have now contributed to a review in this area to be published in 2020. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.icohar2019.org/icohar2019/organization.html |
| Description | Stand at the Royal Highland Show, including the BBSRC-funded Flu Fighters exhibit. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Roslin Institute stand at the Royal Highland Show 22-25 June 2017. Approximately 25 Roslin Institute staff and students were involved. Exhibits of relevance to this ISP include the BBSRC-funded Flu Fighters exhibit, highlighting the problem of influenza and our research to combat it. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Summer course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Armidale Animal Breeding Summer Course 2018: Mathematical modeling of infection dynamics in genetically diverse livestock populations Teachers: Andrea Doeschl-Wilson and Osvaldo Anacleto Dates: Monday 5 February 2018 (9am) - Thursday 8 February 2018 (4pm) Venue: University of New England, Armidale, NSW Australia; ~40 post-graduate students, academics and industrial researcher attended the workshop in modelling. Based on the positive course evaluation, the course sparked new research in the important field of mathematical modelling of infection dynamics and genetics |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://jvanderw.une.edu.au/aabc2018.htm |
| Description | Swine Practitioner workshop - China |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Practitioners met to learn about advances in PCV2 research including control and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Swine Practitioner workshop - France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Key opinion leaders from Asia were invited to discuss advances in PCV2 research including control and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Swine Practitioner workshop - Germany |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | 3--40 veterinarians/industry representatives discussed other approached to diagnose and treat infectious disease in pigs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Swine Practitioner workshop - Korea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We discussed novel approaches to diagnose and treat infectious disease in pigs. We also discussed to make a workshop in China which will occur in November 2020 |
| Year(s) Of Engagement Activity | 2019 |
| Description | TEDx Talk by Professor Helen Sang on 'Why do we need GM chickens?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Helen Sang delivered a Tedx Talk in Glasgow on 2 June 2017 on 'Why do we need GM chickens?'. The event was attended by approximately 1700 people and has been shared online with over 900 views. It highlighted the challenge of achieving global food security and the potential of BBSRC-funded research to improve poultry, including via genetic alteration. Examples for ongoing research using GM poultry in this programme were shared. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.youtube.com/watch?v=DUbqrh5otWs |
| Description | Talk at Royal Highland Show, R(D)SVS stand |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk at Royal Highland Show, Royal (Dick) School of Veterinary Studies stand |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk at the American Society for Virology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation on "Using precision editing tools and novel pig stem cell technology to generate PRRSV-resistant pigs". Attended primarily by international researchers, but also media, industry, and third sector organisations. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk on genome editing at Newcastle University Animal Science Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Talk on genome editing at the Newcastle University Animal Science Conference 2021. Fantastic discussion on regulation and great interaction with students on the subject. Great feedback and interest in the area. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk to undergraduate veterinary students as part of Wellcome funded INSPIRE scheme |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | A short talk was given on my career, choice of research path in order to enthuse undergraduate veterinary sciences students and encourage them to consider a career in science. This was part of a Wellcome Trust funded initiative called INSPIRE. This was well attended, and the students asked a lot of questions related to careers for vets that could combine science as well as veterinary medicine. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk: Genome functional annotation of the six major European farmed fish species - 38th International Society for Animal Genetics Virtual Conference (2021) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | This was an online talk at the Domestic Animal Sequencing and Annotation Workshop of ISAG 2021. There was an international audience including other academics working on FAANG projects, as well as industry researchers working in animal breeding. The main impact was knowledge exchange about the AQUA-FAANG project and its impacts. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=LHnTqwawZXg&t=751s |
| Description | The Human Body activities at a BBC-sponsored Edinburgh Festival event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Researchers from The Roslin Institute joined colleagues from across the University's College of Medicine and Veterinary Medicine in the grounds of George Heriot's School in central Edinburgh to deliver family-friendly activities about 'The Human Body' on 15 August 2017. The event was part of a series of science-themed activities hosted by the BBC at the Edinburgh Festivals to support BBC Learning's 'Terrific Scientific' campaign, which aims to inspire children and young people to engage with science. Our staff and Ph.D students ran interactive activities about their research on lungs and skin, including inflating and examining real pig lungs, comparing healthy and diseased organs, and a chance for visitors to use their craft skills to make a model of their skin. Other activities at the event included anatomy face and body painting and a chance to see dissections of animal brains and hearts close-up. An estimated 1,400 family visitors were engaged, with great questions about our research and what it's like to work as a scientist. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ed.ac.uk/roslin/community-engagement/public-events/events-archive/the-human-body-bbc-at-... |
| Description | The Lab Skills Teacher Information Session (online) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | We have selected eight Scottish high schools in our target demographics of pupils living in rural isolation and/or socioeconomic deprivation, and we will work with nine Nat 5 Lab Skills classes between March and June 2022. Around 120 pupils will take part in the full programme, each receiving at least six hours interaction time with Roslin Institute staff, plus our support for class teachers to supervise pupil investigations and reports. We have also offered free EBSOC Lab Skills workshop sessions to classes from 17 additional schools, who expressed an interest in the programme but could not be accommodated, increasing our potential for impact. |
| Year(s) Of Engagement Activity | 2022 |
| Description | The Poultry Site - MDV |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Media article on The Poultry Site led to increased awareness of publication on resistance to Marek's Disease Virus |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thepoultrysite.com/news/2020/10/genetics-breakthrough-could-help-treat-mareks-disease |
| Description | The Scotsman Data Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Debate on genome editing, use of data in agriculture and breeding. |
| Year(s) Of Engagement Activity | 2021 |
| Description | The Skills Lab 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | We have worked with 8 schools and their pupils studying the National 5 Skills for Work: Laboratory Science AKA Nat 5 Lab Skills, to pilot this new project from the Easter Bush Science Outreach Centre here at the University of Edinburgh. The Skills Lab aims to build confidence in science skills and increase aspiration around careers in STEM for learners from low science capital backgrounds, with a focus on laboratory skills and technical careers; and to remove barriers (both financial and attitudinal) that prevent some learners attending sessions at the Easter Bush Science Outreach Centre (EBSOC). As such we prioritised working with classes of pupils who are not on a Higher/Advanced Higher science track, and are instead taking the Nat 5 Lab Skills course as an alternative science qualification. |
| Year(s) Of Engagement Activity | 2022 |
| Description | |