Mechanistic understanding of virus pathogenesis and resistance
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Endemic and exotic virus diseases pose a major threat to the livestock industry worldwide and in the case of potential zoonoses impinge on wider human welfare. Understanding mechanisms of virus pathogenesis in mammals and birds has major implications for identifying strategies that can translate to the clinic. We will i) exploit Roslin’s expertise in post genomic technologies to identify new viruses of veterinary importance, ii) map the viral genes associated with disruption of the innate immune response (PRRSV, influenza virus), iii) investigate the role of small non-coding RNA in beta- and gamma-herpesvirus infection and iv) explore the epidemiology and aetiology of newly discovered viruses.
Planned Impact
unavailable
Organisations
- University of Edinburgh (Lead Research Organisation)
- Moredun Research Institute (Collaboration)
- Free University of Berlin (Collaboration)
- Government of Canada (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- Zoetis (Collaboration)
- French Agency for Food, Environmental and Occupational Health & Safety (ANSES) (Collaboration)
- Wellcome Trust (Collaboration)
- INDIAN COUNCIL OF AGRICULTURAL RESEARCH (Collaboration)
- Iowa State University (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- Experimental Zooprophylactic Institute of the Venezie (Collaboration)
- ANIMAL AND PLANT HEALTH AGENCY (Collaboration)
- University Libre Bruxelles (Université Libre de Bruxelles ULB) (Collaboration)
- THE PIRBRIGHT INSTITUTE (Collaboration)
- Wageningen University & Research (Collaboration)
- Utrecht University (Collaboration)
- Fonds de la Recherche Scientifique (Collaboration)
- Genus plc (Collaboration)
- Hungarian Academy of Sciences (MTA) (Collaboration)
- International Livestock Research Institute (ILRI) (Collaboration)
- Hokkaido University (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- Animal Health Service (Collaboration)
- US Geological Survey (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Konkuk University (Collaboration)
- Animal Health Research Institute (Collaboration)
- Boehringer Ingelheim (Collaboration)
- National Food Chain Safety Office (Collaboration)
- Virginia Tech (Collaboration)
- Animal and Plant Quarantine Agency (Collaboration)
- National Veterinary Institute (Collaboration)
- Chinese Academy of Agricultural Sciences (Collaboration)
- Erasmus MC (Collaboration)
People |
ORCID iD |
| Paul Digard (Principal Investigator) |
Publications
Akram K
(2018)
Erratum: An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection
in Mucosal Immunology
Akram KM
(2018)
An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.
in Mucosal immunology
Almine JF
(2017)
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.
in Nature communications
Andersen SH
(2017)
Quantification and phenotypic characterisation of peripheral IFN-? producing leucocytes in chickens vaccinated against Newcastle disease.
in Veterinary immunology and immunopathology
Arabi YM
(2017)
Middle East Respiratory Syndrome.
in The New England journal of medicine
| Description | • We have identified and/or shown a role in pathogenicity for three previously unknown influenza A virus (IAV) proteins. This work has been published in Science, PLoS Pathogens and J. Gen. Virol. (PIs Digard, Dutia and Nash). We also explored the interaction of IAV with macrophages in vitro and in vivo with particular emphasis on the role of macrophage phenotype in virus replication and outcome of infection (work published in J. Gen Virol). We showed that alternatively activated macrophages are more readily infected and killed by IAV but produce lower inflammatory responses. In vivo the inability to produce an inflammatory response results in amelioration of infection suggesting novel approaches to control of infection. • Alteration of CpG/UpA dinucleotide frequencies in viral genomes, without changing protein sequences, was found to profoundly affect viral replication leading to papers in PNAS, eLife and Nucleic Acids Research (PIs Simmonds, Digard, Beard and Dutia). This informs the rational design of live-attenuated viral vaccines (as pursued via Sparking Impact funds) and primed a c. £1m Wellcome Trust Senior Investigator Award to Prof. Peter Simmonds. • We investigated the role of small non-coding RNAs in herpesvirus infection. Firstly, we characterised the expression of murine gammaherpesvirus 68 miRNAs in vitro and in vivo. This unique natural model of gammaherpesvirus infection allowed us to identify patterns of infection during acute and latent infection in vivo and, by construction of a deletion mutant, we were able to investigate the roles of a subset of miRNAs in pathogenesis. This award also contributed to studies on the role of gammaherpesvirus encoded chemokine binding proteins in the establishment of latent infection showing that they contribute to the establishment of latency by down regulation of immune responses. Using RISC immunoprecipitation we generated the first systematic analysis of miRNA targets in the context of human cytomegalovirus (HCMV) infection. Multiple targets were validated and the top target, ATP6V0C was shown to be essential for virus replication. Knockdown of this gene resulted in a striking assembly and egress phenotype and suggest that inhibiting the cellular V-ATPase could be an effective therapeutic target for HCMV infection. (PIs Dutia, Grey) • We have developed a number of tools and methods that enable researchers to access, use and manipulate large sequencing datasets. Specifically for this ISP, we published viRome, an R package which looks for signatures of both viRNA and piRNA responses in small RNA datasets (http://www.ark-genomics.org/bioinformatics/virome.). Insects are important vectors of viral diseases of both humans and animals; and the insect immune response to viruses often includes both a small RNA (viRNA) and PIWI-interacting RNA (piRNA) response. Using viRome, we studied the small RNA response in insect vectors to a range of important viruses. We found that the Culicoides midge raises both a viRNA and piRNA response to both bluetongue virus and Schmallenberg virus (published in J. Virol); that knockdown of PIWI proteins results in enhanced Semliki Forest virus production, indicating an anti-viral function (published in J. Gen Virol); we characterized the antiviral RNAi response in tick cells infected with Flaviviruses (published in Nucleic Acids Research); and further characterised the tick response (both Ixodes scapularis and Ixodes ricinus) to tick-borne encephalitis virus; and finally characterised the antiviral RNAi response in vector and non-vector cells against Orthobunyaviruses. (PI Watson). • The ISP funding has supported research into the interactions between poxviruses and their host cell. We carried out a high throughput loss of function screen of Vaccinia virus (VACV) replication using a RNAi library which identified 153 pro- and 149 anti-viral host factors that strongly influenced VACV replication. The most interesting of these hits have been studied in greater detail, with TRAF2 shown to promote VACV entry, RAB1A to facilitate virion morphogenesis, and the retrograde transport pathway to enable the unique double-wrapping step of virion maturation. These articles have contributed to the scant literature on host cell proteins and pathways which influence VACV replication. They represent fundamental research knowledge which will be applied to improve the clinical uses of VACV as a vaccine and an oncolytic therapy. The work was published in J Virol, Virology, PloS ONE and Nature Communications (PIs Beard, Digard). • We have continued our studies of a range of avian oncogenic viruses, including the characterisation of a number of important avian cell types and lines (many transformed by oncogenic viruses). We have discovered and published microRNAs associated with duck-enteritis virus (published in J. gen. Virol); we published (J. Virol) one of the first examples of a retrovirus using canonical processing mechanisms to generate a novel viral microRNA, with possible roles in myeloid leucosis ; we have demonstrated that the oncoprotein encoded by REV-T, v-Rel (an NF-kappa-B orthologue) binds upstream of gga-miR-155 during infection and promotes massive expression of this microRNA, manipulating both the host immune system and the cell cycle (J. Gen. Virol); finally, we have discovered and published genes differentially expressed during spontaneous reactivation of Marek's disease virus (accepted for publication). More generally, we have produced additional datasets that enable us to study gene regulation during transformation of avian cells by oncogenic viruses, including transcription factor binding, methylation patterns and gene expression/RNA-Seq. (PI Watson). • In 2014-2015 there was a large outbreak of highly pathogenic bird flu in Asia, Europe and North America. We, together with other global partners (in The Global Consortium for H5N8 and Related Influenza Viruses) analysed avian influenza sequences collected by all the partners. In particular we led sophisticated phylodynamic analyses on the viral sequence data and were able to show that this was not the usual H5N1 strain, but a new reassortment, H5N8 which was spread by wild long range migrating bird populations (published in Science). Consequently we helped advise the respective governments, including the Scottish Government about the avian influenza incursion risk to domestic flocks from wild birds. |
| Exploitation Route | At the academic level, this section of the Institute Strategic Programme grant has generated a wealth of research data and findings that serve to underpin future research and grant applications, by ourselves and others, as well as leading into numerous interactions with industrial partners. Further specific examples are: We have put IP protection in place for the idea of altering CpG/UpA dinucleotide frequencies as a means of developing safe and effective vaccines and have found an industry partner to develop the technology further The avian influenza phylodynamics work is ongoing - the virus was detected again in 2016, and by autumn/winter 2016 there were new outbreaks across Europe, so again we analysed the viral sequence data for origin and spread, and contributed information to the Scottish Government about the disease incursion risk to domestic flocks from wild birds, ultimately resulting in the domestic bird housing order in place until the end of Feb 2017. |
| Sectors | Agriculture Food and Drink Healthcare Government Democracy and Justice Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | By understanding how important viral diseases interact with their hosts, we can better design intervention strategies such as novel vaccines, drugs and targeted gene drives. This may result in better farm animal production and increased human health via the reduction of the impact of animal and human diseases. BBSRC strategic investment at Roslin via this and other Institute Strategic Programmes has sustained expertise and facilities that have attracted substantial inward investment at the Easter Bush Campus. This has recently included a £15M Gates Foundation funding to establish the Centre for Tropical Livestock Genetics & Health to implement genetic gain and treatments in support of farmers in low- and middle-income farmers, including to control endemic and zoonotic diseases. It has also driven dozens of productive collaborations with industry via contracts and leveraging schemes, leading to a £10M private equity investment to form Roslin Technologies to commercialise our research and construction of a new £32M Innovation Centre adjacent to the Institute to engage and grow businesses. Moreover, the expertise supported by this funding has attracted major investment in Agri-Tech Centres at Easter Bush funded by InnovateUK (Centre for Innovation Excellence in Livestock & Agri-EPI). These Centres will increase national capacity for infectious challenge in farmed animals, gene editing and collection of novel phenotypes and be linked to stakeholders throughout the food supply chain. |
| First Year Of Impact | 2016 |
| Sector | Agriculture, Food and Drink,Healthcare,Government, Democracy and Justice |
| Impact Types | Economic |
| Description | EPIC 2 |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | Epidemiologic projects are providing 'real world' impact, with the EPIC2 consortium project (£9.4M of funding in total, including £700 to the RI) providing expert advice to the Scottish Government and industry stakeholders on exotic (and increasingly endemic) disease risks. Strands of forecasting and 'horizon scanning' work include risk assessments of the introduction of West Nile virus into the South of England and the spread of Schmallenburg virus (SBV) into Scotland. |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://www.oie.int/fileadmin/home/eng/Media_Center/docs/pdf/PortailAI/H5N8_OFFLU_Statement-1.pdf |
| Description | (DELTA-FLU) - Dynamics of avian influenza in a changing world |
| Amount | € 5,497,794 (EUR) |
| Funding ID | 727922 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2017 |
| End | 11/2022 |
| Description | BBSRC Animal Health Research Club |
| Amount | £94,126 (GBP) |
| Funding ID | BB/M502972/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2020 |
| Description | BBSRC Animal Health Research Club |
| Amount | £94,126 (GBP) |
| Funding ID | BB/M502984/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2018 |
| Description | BBSRC responsive mode |
| Amount | £682,857 (GBP) |
| Funding ID | BB/P003966/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2020 |
| Description | BBSRC strategic LOLA |
| Amount | £458,687 (GBP) |
| Funding ID | BB/K002465/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2013 |
| End | 05/2018 |
| Description | BBSRC/India DBT Joint call in farmed animal diseases |
| Amount | £1,300,000 (GBP) |
| Funding ID | BB/L004666/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 10/2017 |
| Description | Boehringer Ingelheim The PCV2 European Research Award |
| Amount | € 25,000 (EUR) |
| Organisation | Boehringer Ingelheim |
| Department | Boehringer Ingelheim |
| Sector | Private |
| Country | Canada |
| Start | 02/2017 |
| End | 04/2018 |
| Description | CALL: INTEGRATING AND OPENING RESEARCH INFRASTRUCTURES OF EUROPEAN INTEREST |
| Amount | € 10,000,000 (EUR) |
| Funding ID | H2020-INFRAIA-2016-1 project number 731014 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2017 |
| End | 03/2022 |
| Description | CASE studentship |
| Amount | £90,000 (GBP) |
| Funding ID | BB/L004666/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 08/2017 |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £312,917 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 05/2022 |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £384,966 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | EPIC: Centre of Expertise on Animal Disease Outbreaks |
| Amount | £10,000,000 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 04/2021 |
| Description | EU H2020 |
| Amount | € 5,500,000 (EUR) |
| Organisation | European Commission |
| Department | Horizon 2020 |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | H2020 |
| Amount | € 5,500,000 (EUR) |
| Funding ID | DELTA-FLU |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 04/2017 |
| End | 04/2022 |
| Description | Houghton Trust small project grants |
| Amount | £5,000 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 01/2017 |
| Description | Identification of interferon stimulated genes that control Toxoplasma in pig macrophages |
| Amount | £470,900 (GBP) |
| Funding ID | BB/W014807/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2025 |
| Description | Identification of interferon stimulated genes that restrict cross-species transmission of influenza A virus. |
| Amount | £614,702 (GBP) |
| Funding ID | BB/S00114X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 09/2023 |
| Description | Interferon-stimulated genes as resilience factors for PRRSV infection |
| Amount | £642,924 (GBP) |
| Funding ID | BB/T015179/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 11/2024 |
| Description | MRC project grant |
| Amount | £674,045 (GBP) |
| Funding ID | MR/M011755/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 01/2018 |
| Description | MRC project grant |
| Amount | £476,066 (GBP) |
| Funding ID | MR/N001796/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2015 |
| End | 12/2018 |
| Description | Mobility grant for staff teaching/training |
| Amount | £804 (GBP) |
| Organisation | Erasmus + |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 03/2017 |
| Description | Principal's Career Development PhD studentship |
| Amount | £72,000 (GBP) |
| Organisation | University of Edinburgh |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 08/2016 |
| Description | Project grant |
| Amount | £873,050 (GBP) |
| Funding ID | MR/M011747/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 05/2018 |
| Description | Sir Henry Dale Fellowship - Eleanor Gaunt - The role of CpG dinucleotides in regulating virus replication kinetics |
| Amount | £1,025,674 (GBP) |
| Funding ID | 211222/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2023 |
| Description | Tools and Resources Development Fund |
| Amount | £144,529 (GBP) |
| Funding ID | BB/N021738/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 09/2017 |
| Title | CDCD pig model |
| Description | We improved a caesarean-derived, colostrum deprived pig model to ensure that animal welfare and survivability of pigs increases. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2014 |
| Provided To Others? | No |
| Impact | Survivability of pigs increased from 50% to 90-100% |
| Title | ELispot for PCV2 |
| Description | The assay is able to detect a cellular immune response to PCV2. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Improvement of vaccine efficacy assessment. |
| Title | In silico generation of genome wide guide sequences for pig and chicken |
| Description | One of the aims of the project is to design CRISPR guide sequences against each of the annotated genes for pig and chicken using the most advanced algorithms available. this has now been achieved and selected guide sequences are being test in pig and chicken cell lines to determine efficacy. Once the full libraries have been validated the guide sequences will be made publicly available through dedicated pig and chicken genome websites. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Once publicly available, any researcher will be able to search for guide sequences to their gene of interest, allowing rapid generation of guide sequences to generate knockout libraries. |
| Title | In vitro infection model for Porcine Reproductive and Respiratory Syndrome |
| Description | Peripheral blood monocytes (PBMC) are isolated from blood and either cryopreserved or used immediately. PBMC are cultured in vitro in the presence of CSF1 for 5 days.Growth in the presence of CSF1 facilitates the differentiation of PBMC into macrophages. These in vitro differentiated macrophages are subsequently infected with Porcine Reproductive and Respiratory Syndrome Virus, |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | The in vitro PRRS infection model facilitates studies of genetic variation in both host (pigs) and pathogen (e.g. PRRSV) simultaneously. Unlike for the laboratory mouse there is an absence of inbred strains or lines of pigs. The PBMC resource allows the same pig to be infected separately with multiple different pathogens or genetic variants of a pathogen. The PBMC resource and in vitro PRRS infection model also facilitates genetics studies that require population or sample sizes of hundreds to thousands that are not feasible through animal challenge experiments. Thus, the in vitro infection model also contributes to the 3Rs agenda. |
| Title | PDCoV-ELISA |
| Description | A test to develop antibodies to PDCoV IgA and IgG antibodies for early detection of infection was developed. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | The test is used for early detection of infection of a pig herd with PDCoV. |
| Title | PEDV assay |
| Description | An ELISA for detection of IgG and IgA PEDV antibodies was developed. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Test is used to determine if pig herds are free of PEDV |
| Title | Cool tools - a biologist friendly parameterized model of an influenza A virus infected cell |
| Description | There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour. We presented a new, freely available modelling framework that includes a biologist-friendly pathway modelling language (mEPN), a simple but sophisticated method to support model parameterisation using available biological information; a stochastic flow algorithm that simulates the dynamics of pathway activity; and a 3-D visualisation engine that aids understanding of the complexities of a system's dynamics in a publication in the journal PloS Biology. We presented example pathway models that illustrate of the power of approach to depict a diverse range of systems, including a parameterized model of an influenza A virus infected cell. For more details on the assembly and parameterisation of this pathway and to download the pathway itself, see S2 Text, S2 Graphml, S2 Fig and S3 GraphML in: http://dx.doi.org/10.1371/journal.pbio.1002530.g005 |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Too early to say, but the publication has been viewed nearly 8000 times in the 7 months since it was published. |
| Title | Loss of function RNAi screen of Vaccinia virus replication in HeLa cells |
| Description | A functional high throughput small interfering RNA (siRNA) screen targeting 6719 druggable cellular genes was undertaken to identify host factors (HF) influencing the replication and spread of VACV. The results of the screen were made available at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098431#pone.0098431.s001 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | This was one of the first RNAi screens undertaken for poxvirus replication and has been used by many groups to identify host proteins or pathways to target to modulate poxvirus disease. |
| URL | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098431#pone.0098431.s001 |
| Title | MOESM1 of Effects of mutations in the effector domain of influenza A virus NS1 protein |
| Description | Additional file 1: Table S1. Mascot search results from LC-MS analysis of the novel polypeptide band in lane 8 of Fig. 2c. The data include a summary of protein IDs followed by details on the individual peptide hits. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Effects_of_mutations_in_the_effector_domain_o... |
| Title | MOESM1 of Effects of mutations in the effector domain of influenza A virus NS1 protein |
| Description | Additional file 1: Table S1. Mascot search results from LC-MS analysis of the novel polypeptide band in lane 8 of Fig. 2c. The data include a summary of protein IDs followed by details on the individual peptide hits. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Effects_of_mutations_in_the_effector_domain_o... |
| Title | Modulation of host cell miRNAs by Vaccinia virus |
| Description | Vaccinia virus causes dramatic alterations to many cellular pathways including microRNA biogenesis. The virus encodes a poly(A) polymerase which adds poly(A) tails to the 3' end of cellular miRNAs, resulting in their degradation by 24 hours post infection (hpi). Here we used small RNA sequencing to quantify the impact of VACV infection on cellular miRNAs in human cells at both early (6 h) and late (24 h) times post infection. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | This work led to a PhD studentship which is investigating the alterations of miRNAs by African Swine Fever virus, a virus closely related to Vaccinia virus, in order to see if manipulation of miRNAs can be used as a novel control mechanism for this pig disease. Sequencing data was deposited in GEO database (GSE54235) |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE54235 |
| Title | PRJEB14979 |
| Description | Marek's Disease Virus (MDV) is a widespread alphaherpesvirus of poultry that causes Marek's disease (MD) characterised by fatal visceral CD4+ TCRaß+ T cell tumours at high incidence in susceptible hosts. As is the case with many virus-induced tumours, immortal cell lines harbouring viral genome have been generated from ex vivo cultures of MD tumours. As readily-available sources of large numbers of cells of a uniform type, MDV-transformed lymphoblastoid cell lines (LCL) have proved extremely valuable in studying virus-host interaction. While the viral genome is held in a latent state in most of the cells, a minor population of cells display spontaneous reactivation identifiable by the expression of lytic viral genes such as pp38. The process of spontaneous reactivation in these cell populations offers the opportunity for investigating the biological processes involved in the reactivation events. For this, we used two lymphoblastoid cell lines derived from lymphomas induced by pRB1B-UL47eGFP, a recombinant MDV engineered to express EGFP fused with the UL47. We used Fluorescence-activated cell sorting (FACS) to purify the rare EGFP-positive cell population with spontaneously activating viral genome from the majority EGFP-negative cells and analysed their gene expression profiles by RNA-sequencing using Illumina HiSeq2500. The reads generated were mapped using TopHat and gene expression levels were analysed by edgeR. Ingenuity pathway analysis software on more than 2000 differentially-expressed genes between the lytically infected (EGFP-positive) and latently infected (EGFP-negative) cell populations was used identify major biological pathways involved in the reactivation. These studies revealed that amongst others, transcripts directly involved in T activation such as CD3 complex, CD28, ICOS, phospholipase C, CD3 complex were down-regulated following reactivation of the virus in the LCL. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | These data detail the gene expression changes during spontaneous activation of MDV and will be useful to researchers investigating the mechanism of action of this important virus, as well as in vaccine design |
| URL | https://www.ebi.ac.uk/ena/data/view/PRJEB14979 |
| Description | BIVI Collaboration |
| Organisation | Boehringer Ingelheim |
| Country | Germany |
| Sector | Private |
| PI Contribution | Analysis of samples and consulting on tests and treatment options |
| Collaborator Contribution | Test kits and samples. |
| Impact | Confidentials |
| Start Year | 2013 |
| Description | Biochemical interaction of CD163 with PRRSV glycoproteins GP2, GP3, and GP4 |
| Organisation | Free University of Berlin |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We are providing purified, tagged CD163 protein variations for the assessment of biochemical and biophysical interactions of the protein with the PRRSV glycoproteins GP2, GP3, and GP4 and glycoprotein complex GP2/3/4. |
| Collaborator Contribution | Our collaboration partners area analysing the biochemical and biophysical interactions of CD163 variants with the PRRSV glycoproteins GP2, GP3, and GP4 and glycoprotein complex GP2/3/4 using their established baculoviral expression system. |
| Impact | So far we are in the early stages of this collaboration and many protocols are still being optimised. |
| Start Year | 2018 |
| Description | Collaboration ANSES |
| Organisation | French Agency for Food, Environmental and Occupational Health & Safety (ANSES) |
| Country | France |
| Sector | Public |
| PI Contribution | My research team will work in the ANSES laboratories to set up organotypic avian cultures (intestinal organoids) of chicken, turkey and Guinea fowl which will be a unique opportunity. The organoids will then be infected with a variety of coronaviruses and avian influenza viruses (low and high pathogenic) and the viral replication will be analysed at different time points post infection. The RNA will be isolated and transported back to the UK to investigate the species specific immune responses using a high throughput qPCR array. The Roslin team will train the scientist at ANSES how to culture organoids whereas the team at ANSES will train the ECRs in virological techniques and working in a high containment laboratory. |
| Collaborator Contribution | The team at ANSES will contribute a lot of staff time, the animals, and will do the infection experiment in their high containment laboratory. In addition they will analyse the virus replication (RT-qPCR, egg titration and plaque assays) and we will write a joined publication describing the outcomes of this collaborative project. The data will feed in to many other projects related to avian corona and avian influenza viruses that are ongoing in the Vervelde group. |
| Impact | A collaborative project with ANSES, Ploufragan laboratory (reference lab for avian influenza), was initiated and funded by the BBSRC mitigation fund. This is a multidisciplinary collaboration in which the Roslin ECRs and PI will contribute their expertise in organotypic avian cultures (organoids) and the team at ANSES will contribute their virological expertise, the capacity to work with highly pathogenic avian influenza and their access to poultry species that we do not have in the U.K. (including guinea fowl, SPF turkeys and SPF ducks). The output of this collaboration will be joined peer reviewed publications on on host specific viral entry and immune responses (avian corona viruses and avian influenza viruses), preliminary data for follow on funding and future access to a wealth of virus strains and high containment laboratory and animal facilities. |
| Start Year | 2022 |
| Description | David Griffiths, Moredun |
| Organisation | Moredun Research Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We have been working with David Griffiths at The Moredun Research Institute since 2011 in the study of ovine pulmonary adenocarcinoma |
| Collaborator Contribution | David Griffiths is an expert in the study of ovine pulmondary adenocarcinoma, how the virus functions and how we might design intervention strategies such as vaccines. My group is expert in the use of genomics and bioinformatics and together we are using sequencing to understand how the virus interacts with its host |
| Impact | NA |
| Start Year | 2011 |
| Description | ISU collaboration |
| Organisation | Iowa State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Providing knowhow and imput |
| Collaborator Contribution | Providing laboratory and animal space |
| Impact | Several publications |
| Start Year | 2013 |
| Description | In vivo challenge of genome edited deltaSRCR5 pigs with PRRSV-1 |
| Organisation | Genus plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Following the successful generation of pigs lacking domain 5 (SRCR5) of the CD163 and the promising in vitro results, showing primary cells of these pigs to be resistant against PRRSV infection we obtained further funding from Genus plc. to conduct an in vivo study. 4 delta SRCR5 pigs and 4 wild type pigs were challenged with PRRSV-1. We conducted the study and analysed the outcomes. |
| Collaborator Contribution | Genus plc contributed funding to conduct the in vivo study to assess infectability of delta SRCR5 pigs with PRRSV-1 |
| Impact | We published the results of this study in a scientific publication, disseminated the results in a press release package, as well as presented the work at various scientific conferences and public engagement events. |
| Start Year | 2016 |
| Description | Maintenance of delta SRCR5 pigs |
| Organisation | Genus plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Breeding and maintenance of the genome edited delta SRCR5 pig line from the end of "Engineering resistance to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)" (BB/L004143/1) and the beginning of "Understanding the CD163 - PRRS virus interaction to improve genetic engineering for resistance" (BB/R004463/1). |
| Collaborator Contribution | Genus plc provided the funds for breeding and maintenance of the delta SRCR5 pigs. |
| Impact | The outcomes of this project are directly interlinked with the outcomes of the grants mentioned above. |
| Start Year | 2017 |
| Description | Pirbright Institute |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | As BBSRC Institutes within the National Institutes of Bioscience umbrella we collaborate on a variety of virology projects, pooling expertise, facilities and data. |
| Collaborator Contribution | Please see the specific publications involving joint authors |
| Impact | Toward the aim of defining the basis of resistance of poultry to viral diseases (DO1.2), we analysed the early immune response of Brown Leghorn and inbred line 61 chickens housed by the National Avian Research Facility to infection by Infectious Bursal Disease Virus, in collaboration with The Pirbright Institute. This identified candidate genes and pathways associated with resistance (DOI: 10.1128/JVI.02828-14). Uplift funding totalling >£800k linking Pirbright and Roslin Institute researchers will use epitope fingerprinting to investigate the genetic plasticity of infectious bronchitis virus strains to develop improved cross-protective vaccines (BB/M012069/1). Toward making disease-resistant animals, research linking ISPG2 and ISPG4 aims to define the contribution of RelA polymorphism to resistance to African Swine Fever Virus in pigs. Challenge experiments at The Pirbright Institute are ongoing at the time of writing. We currently have two joint PhD students shared between the Institutes - one (Miss Anabel Clements, supervised by Professor Paul Digard [RI] and Drs Munir Iqbal and Holley Shelton [PI]) is working on virulence determinants of avian influenza virus, while the other (Miss Laura Dunn, supervised by Dr Pip Beard [RI] and Dr Linda Dixon [PI]) is studying miRNA modification by African swine fever virus. Dr Beard, a senior virologist and pathologist has been appointed to a joint Roslin / Pirbright position, starting 1st May, 2016. |
| Description | Roslin-Genus Cooperative Partnership Addendum 16 |
| Organisation | Genus plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Roslin Institute team conceived and executed the research project to test the hypothesis that gene-editing the pig CD163 gene would confer resistance to infection with PRRSV. |
| Collaborator Contribution | The Genus team contributed to the project design and management. |
| Impact | Paper published: Burkard et al. 2017. PLOS Pathogens 1392): e1006206 |
| Start Year | 2010 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal Health Research Institute |
| Country | Taiwan, Province of China |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal Health Service |
| Country | Netherlands |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal and Plant Quarantine Agency |
| Country | Korea, Republic of |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Harbin Veterinary Research Institute (HVRI) |
| Country | China |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Erasmus MC |
| Department | Department of Viroscience |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Experimental Zooprophylactic Institute of the Venezie |
| Country | Italy |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Fonds de la Recherche Scientifique |
| Country | Belgium |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hokkaido University |
| Department | Graduate School of Veterinary Medicine |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hokkaido University |
| Department | Research Center for Zoonosis Control |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hungarian Academy of Sciences (MTA) |
| Country | Hungary |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Konkuk University |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | National Food Chain Safety Office |
| Department | Veterinary Diagnostic Directorate |
| Country | Hungary |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | National Veterinary Institute |
| Country | Sweden |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Department | National Wildlife Research Center |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Southeast Poultry Research Laboratory |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | US Geological Survey |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University Libre Bruxelles (Université Libre de Bruxelles ULB) |
| Department | Spatial Epidemiology Laboratory |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Oxford |
| Department | Centre for Tropical Medicine and Global Health |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Oxford |
| Department | Department of Zoology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Utrecht University |
| Department | Department of Farm Animal Health |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Major Overseas Programme in Ho Chi Minh City Vietnam |
| Country | Viet Nam |
| Sector | Charity/Non Profit |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The National Institute of High Security Animal Diseases (NIHSAD), Bhopal India |
| Organisation | Indian Council of Agricultural Research |
| Department | National Institute of High Security Animal Diseases |
| Country | India |
| Sector | Public |
| PI Contribution | This collaboration is directly funded by a joint grant from the BBSRC and Indian DBT (see further funding awards). The Roslin side brings expertise in avian genomics and influenza A virus molecular biology |
| Collaborator Contribution | Our partners at NIHSAD bring expertise in highly pathogenic influenza A virus pathogenicity studies carried out under high biosafety containment. The overall aim is to investigate the determinant that set resistance or susceptibility to avian influenza amongst diverse birds species including chickens, ducks, pigeons and crows. |
| Impact | See publication: PMID 25592823 |
| Start Year | 2013 |
| Description | VT collaboration |
| Organisation | Virginia Tech |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Developing of a pig model and testing viruses. |
| Collaborator Contribution | Developing vaccines |
| Impact | Several publications |
| Start Year | 2014 |
| Description | Venu Nair, The Pirbright Institute |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have been working with Venu Nair at The Pirbright Institute for over 10 years, broadly in the area of avian oncogenic viruses such as Marek's disease and ALV. |
| Collaborator Contribution | Venu's group are expert in virology and virus research whereas my group is expert in genomics and bioinformatics. Together we use genomics to explore virus-host interactions. |
| Impact | 28113043 24155381 23967013 22492913 19403687 19297609 18256158 |
| Start Year | 2006 |
| Description | Zoetis - emerging pathogens of farmed and companion animals |
| Organisation | Zoetis |
| Country | United States |
| Sector | Private |
| PI Contribution | Work in theme 2 on detection and characterisation of emerging or novel viruses in animals and humans led to the publication of 24 papers. £75k uplift funding was obtained for such research and Zoetis agreed to support a European hub at RI for detection of emerging pathogens of farmed and companion animals. |
| Collaborator Contribution | See above. |
| Impact | Work is ongoing |
| Start Year | 2014 |
| Title | DOMAIN 5 OF CD163 FOR USE IN ANTIVIRAL COMPOSITIONS AGAINST PRRS, AND TRANSGENIC ANIMALS |
| Description | The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD163 in vivo. |
| IP Reference | WO2015011483 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | Steps along the way to converting this intellectual property into socio-economic impact including establishing regulatory approval, if necessary, for products from gene edited pigs to enter the food chain generally or in this specific example and agreeing licensing terms with appropriate players in the agri-food chain. |
| Title | viRome: an R package for the visualization and analysis of viral small RNA sequence datasets. |
| Description | SUMMARY: RNA interference (RNAi) is known to play an important part in defence against viruses in a range of species. Second-generation sequencing technologies allow us to assay these systems and the small RNAs that play a key role with unprecedented depth. However, scientists need access to tools that can condense, analyse and display the resulting data. Here, we present viRome, a package for R that takes aligned sequence data and produces a range of essential plots and reports. AVAILABILITY AND IMPLEMENTATION: viRome is released under the BSD license as a package for R available for both Windows and Linux http://virome.sf.net. Additional information and a tutorial is available on the ARK-Genomics website: http://www.ark-genomics.org/bioinformatics/virome. |
| Type Of Technology | Software |
| Year Produced | 2013 |
| Open Source License? | Yes |
| Impact | NA |
| URL | http://www.ark-genomics.org/bioinformatics/virome |
| Description | 'Science Insights 2022' - Research presentation |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Science Insights is a work placement programme for high school pupils about to enter S6 (final year at high school). Backgrounds and insights around animal biotechnology were presented to the pupils and inspired engaging discussions. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Animal Genetics and Diseases Conference Wellcome Genome Campus, Hinxton, Cambridge, UK : Genome wide CRISPR knockout screen identifies host factors involved in Bovine Herpes Virus Type 1 infection. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at an international conference on Animal genetics and diseases. Reported the use of CRIPSRi screens in cattle, raising awareness of the feasibility of using this approach in the study of host:pathogen interactions in livestock. Feed back from participants was positive and generated discussion. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Annual Roslin Institute Open Doors Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual Roslin Institute Open Doors day was held on 14 October 2017 and was attended by 491 people. It involved 81 members of staff and students and showcased a wide range of research arising from BBSRC strategic investment, including (but not limited to), food safety, influenza, genetic improvement, DNA, imaging and the ethical treatment of animals in research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Avian Pathogenesis Meeting, Shanghai Veterinary Research Institute. "Generation of genome wide CRISPR Cas9 libraries for pig and chicken" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Avian Pathogenesis Meeting was organised to provide an opportunity for interaction and collaboration with veterinary scientists from China. I presented our work on genome-wide CRISPR/cas9 libraries for pig and chicken and ISG libraries for pig and chicken. We highlighted our new capability to perform high throughput systematic functional screens in livestock species. Potential collaborations and sharing of resources were discussed and are currently being acted on. |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBSRC Animal Health Research Club Fourth Dissemination Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | A retrospective report on the BBSRC Animal Health Research Club project on "Engineering resistance to Porcine Respiratory Syndrome virus (PRRSV)" was presented including the ongoing research in the BBSRC project " Understanding the CD163 - PRRS virus interaction to improve genetic engineering for resistanc" (BB/R004463/1) and outreach activities. This was followed by questions and discussions from/with scientists engaged in other BBSRC Animal Health Research Club and with representatives from the industrial co-funders of the BBSRC Animal Health Research Club. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Bike riding and science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | "Science in the Saddle". The Midlothian Ranger Service and scientists from The Roslin Institute combined to provide a grand day out on the bike for the general public in Midlothian's countryside. It was a gently paced cycle with frequent stops to hear scientific talks. I spoke about post mortem examinations and how they help scientists in 2013, and smallpox and its relevance to us today in 2014. The major advantage of this method of public engagement is after you give your talk to the group you continue riding through the countryside with the group of cyclists and have a chance to chat informally about your information. |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | CPD event for High School Biology teachers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | SSERC CPD Summer School for 22 high school teachers. A lecture on the principles and application of genome editing and delivery of parts of a workshop we were developing on "Cows, Coughs and CRISPR". The participants reported an increased understanding of the topic and their feedback on the workshop allowed us identify an appropriate level of content and to further tailor it to the needs of the school curriculum. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Come Dine With The Future |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | What will we be eating in 50 years time? H Sang and 4 other presenters described what will be on their dinner menu, considering advances in technology and challenges of sustainability |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.youtube.com/watch?v=Bkta-s7z9DY |
| Description | Communicating Science to budding scientists at Abbotsleigh School for Girls in Sydney |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Pip Beard and Megan Davey from The Roslin Institute held a video conference with year 9 science students (14 year olds) and discussed their work. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Easter Bush Campus annual open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual Roslin Institute Open Doors day was held on 13 October 2018 and was attended by over 600 people. It showcased a wide range of research arising from BBSRC strategic investment, including (but not limited to), gene editing food safety, influenza, genetic improvement, DNA, imaging and the ethical treatment of animals in research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Edinburgh Science Festival, Flu Fighters |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participated in Flu Fighters during the Edinburgh Science Festival 2015. We showcased the exhibit 'Flu Fighters' at the festival. The 'Flu Fighters' exhibit focuses on influenza viruses and the science behind the varied approaches to combating flu being developed at Roslin and Pirbright. It showcases current research including GM animals, novel approaches to vaccines and diagnostic tests and host/virus genetics. The exhibit also demonstrates how flu transmits from animals to humans and highlight the challenges of preventing large-scale outbreaks.The 'Flu Fighters' exhibit provides an opportunity for visitors to run diagnostic tests on a chicken, design their own flu virus and discuss the pros and cons of genetic modification of animals. Over 100 people attended the morning and the activities sparked questions from both children and parents/carers. A better understanding of the problem for the poultry industry, eco system (wild birds) and human health was reported back. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Flu Fighters public exhibition stand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 4. With £10k BBSRC funding, ISPG4-funded researchers jointly developed 'Flu-Fighters', an interactive exhibit suitable for children and adults highlighting our research to create influenza-resistant farm animals, develop improved vaccines and diagnostic tests, and understand the role of viral and host factors in the outcome of infection. This was run over three days in November 2014 at the Great British Bioscience Festival (visited by over 6500 people) as part of BBSRC's 20th anniversary programme. ISPG4 scientists were involved in running it again at the Royal Society's 2015 Summer Science Exhibition in London. |
| Year(s) Of Engagement Activity | 2014,2015,2016 |
| Description | Genome Wide CRISPR Knockout Screen Identifies Host Factors Important for Bovine Herpes Virus Type 1 Replication. Plant and Animal Genomics PAG 2020 San Diego, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | PAG is the major international conference on plant and animal genetics. Reported the use of CRIPSRi screens in cattle, raising awareness of the feasibility of using this approach in livestock to study genetic basis of susceptibility or resistance to pathogens. Feed back from participants was positive and generated discussion. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Genome Wide CRISPR Knockout Screen Identifies Host Factors Involved in Bovine Herpes Virus Type 1 Infection. Genome Science Edinburgh, UK Invited speaker ( Dr W. Tan) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at an international genetics conference. Reported the use of CRIPSRi screens in cattle, raising awareness of the feasibility of using this approach in the study of host:pathogen interactions in livestock. Feed back from participants was positive and generated discussion. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gorebridge Girl Guides visit to Roslin |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | The Gorebridge Girl Guides visit the Roslin Institute for a day to see what being a scientist involves. Gorebridge is a deprived area of Edinburgh with high unemployment and low tertiary education levels. The girls who attended reported surprise at seeing female scientists, and agreed the day had changed their perception of what a research scientist was. |
| Year(s) Of Engagement Activity | 2011 |
| Description | H5N8 bird flu press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about H5N8 bird flu study; also covered by BBC news http://www.bbc.co.uk/news/science-environment-37643894 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.roslin.ed.ac.uk/news/2016/10/14/migration-routes-hold-key-to-bird-flu-spread-global-study... |
| Description | Institute of Animal Pathogology, University of Bern. "Bringing high throughput approaches to livestock species". Invited talk. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Was invited to Bern to present on our work on developing CRISPR/Cas9 and ISG libraries for pig and chicken. Collaborations and sharing of resources were discussed and are being put into action. Additionally the visit was organised to increase links with an institute with aligned scientific interests. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited Speaker - 33rd ENGL Plenary Meeting - European Commission |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation on novel breeding technologies in animals and how advances can help us face global challenges. Attendees from the European Commission, Ministries from European member states, researchers and the overall audience showed a keen interest in the advances recently made in the animal biotechnology sectors. There is a clear interest in regulating and thereby opening the pathway to integration of novel breeding technologies from member states. The discussion was very engaged and has since lead to more specific interactions with the ministries of individual member states. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Talk at the Wellcome Animal Genetics and Diseases conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | As part of the Wellcome Animal Genetics and Diseases conference I presented our and other peoples work on genome editing for disease resistance and production traits in livestock. The audience was a conglomerate of national and international scientists at all career stages and highly engaged in debating both scientific as well as policy questions surrounding genome editing technology. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited lecture at MSD-Animal Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited lecture at MSD-Animal Health in Boxmeer the Netherlands, with WebEx connection to all other location o MSD -AH around the world. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited participation - 2nd Albrecht Mueller ARRIGE Seminar |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Important discussion around the Social and Ethical Implications of Genome Editing in Animals. Particularly impactful in the context of the Genetic Technology (Precision Breeding) bill in the UK and linked responses from interested parties. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.arrige.org/portfolio/2nd-albrecht-muller-arrige-seminar/ |
| Description | Invited presentation - 4th International Workshop on Regulatory Approaches for Agricultural Applications of Animal Biotechnologies |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Workshop discussions on international trade and regulation of novel breeding technologies in animal biotechnology. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited talk European Veterinary Vaccinology Workshop 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on career opportunities in academia for young scientists |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=hTujbImUCcI |
| Description | Invited talk at the Swiss Virology Meeting 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk presenting an overview or our research activities from genome editing, primary cell models (including organoids, iPSCs, primary cells, complex cell models) with a primary focus on genome editing. |
| Year(s) Of Engagement Activity | 2023 |
| URL | http://swissvirology.ch/ |
| Description | Lothian Agricultural Discussion Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Visit by the Lothian Agricultural Discussion group to the Large Animal Research and Imaging Facility. Primarily from a farming or veterinarian background the audience was engaged in listening to the talks and asking further questions around biotechnology and animal research. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Media attention after launch project initiated by Prof L Vervelde |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Press release after launch project received a lot of attention https://www.thepoultrysite.com/articles/bird-influenza-tests-being-research-that-can-assess-emerging-strains https://www.farminguk.com/news/new-bird-flu-tests-to-assess-emerging-strains_57986.html https://www.poultrynews.co.uk/news/researchers-target-mutating-avian-influenza-strains-in-new-study.html https://www.pressandjournal.co.uk/fp/business/farming/3050836/scots-scientists-to-develop-new-tissue-tests-to-detect-bird-flu/ https://mrcvs.co.uk/en/news/20367/Scientists-seek-avian-flu-tests-to-assess-emerging-strains https://www.thepoultrysite.com/news/2021/04/researchers-begin-developing-tissue-tests-to-detect-emerging-bird-flu-strains |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.thepoultrysite.com/news/2021/04/researchers-begin-developing-tissue-tests-to-detect-emer... |
| Description | One Health Models of Infectious Disease. University of Edinburgh. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting our work on generation of genome wide CRISPR Cas9 libraries for pig and chicken. The meeting was aimed at establishing a Wellcome Trust studentship program at the Roslin Institute. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation by Dr S. Sives at Edinburgh Infectious Diseases Early Career Symposium (online) , 28th October 2021. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A flash oral presentation was given at an online event specifically for early career researchers, the inaugural Edinburgh Infectious Diseases Early Career Research Symposium, October 28th 2021. Early career researchers actively involved in infectious disease research presented a diverse range of research. The audience consisted of postgraduate, post-doctoral and principal scientists from across the University of Edinburgh. The event was designed to enhance collaboration and networking opportunities across diverse research groups and engage with other attendees allowing discussions around future research plans. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ed.ac.uk/edinburgh-infectious-diseases/news/upcoming-events/eid-ecr-symposium |
| Description | Peebles Brownies Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 80 brownies attended a hands on workshop aimed at educating girls in the career opportunity's available in science |
| Year(s) Of Engagement Activity | 2015 |
| Description | Poster Presentation by Dr S Sives at the 7th European Veterinary Immunology Group Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A poster presentation was given at the 7th European Veterinary Immunology workshop, held on-line between 29th - 31st August 2021, this meeting is designed to enhance collaboration and network opportunities between worldwide veterinary immunologists. The audience included post-graduate students, peers and experts within the wider field of veterinary immunology and were actively involved in discussions about the project. It was an excellent opportunity to network with colleagues outside the avian immunology field. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://7theviw.org/index.php?r=site/programme |
| Description | Poster presentation by Dr S. Sives at British Society for Immunology Congress, 28th November - 1st December 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A poster presentation was given in-person at the British Society for Immunology Congress 2021 in Edinburgh. This annual event is the UK's premier immunology congress, attracting over 1000 attendees with cutting-edge research from leading UK and international researchers. The event was designed to enhance collaboration and networking opportunities across research groups working across the breath of immunology. During the poster session there was a lot of engagement with attendees. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/titem.csp?pageID=5087&eventID=8 |
| Description | Presentation to the BBSRC executive committee "Bringing high throughput approaches to livestock species" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The BBSRC executive were visiting Roslin Institute to review on going research programs as part of the ISP funding. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to the Slovenian ministries of agriculture, economy, and higher education on genome editing in animals |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | An presentation on the use of new breeding technologies in animals to tackle global challenges. Engaged discussion with the participants on how these technologies can be regulated and integrated in international livestock production. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press reports on PRRSV-resistant pigs |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In connection with the publication of our research paper "Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection" (doi: 10.1128/JVI.00415-18) we published a press package and answered interview request from many broadcasting and media agencies. As a result the following print and broadcast pieces were released: International Broadcast: BBC Scotland, BBC News at Six, BBC News at Ten, BBC World, BBC Sunday Morning Live, BBC Radio 4 Farming Today, BBC Radio Five Live, BBC Radio 4, BBC Radio Scotland, BBC World Service, Guardian Podcast, BBC Radio Shetland, Swiss Radio & TV (SRF), Country Today (Victoria, Australia, Radio), Fiji Broadcasting Corporation, France 24 Print UK: The Daily Telegraph, The Times, The Guardian, Scottish Daily Mail, The i, Scottish Daily Express, The Sun, Scottish Sun, Daily Mirror, Daily Star, Metro, The Herald, Scotsman, Daily Record, Dundee Courier, Edinburgh Evening News, Aberdeen Evening Express, The Week, Press & Journal, Yorkshire Post Online UK BBC Online, Daily Telegraph, Daily Mail, The Times, The Guardian, Daily Mirror, Daily Express, Scotsman, Irish News, Irish Examiner, Shropshire Star, Express & Star, Hastings Observer, Scarborough News, Eastbourne Herald, Shoreham Herald, West Sussex County Times, Yorkshire Evening Post, Glasgow South & Eastwood Extra, Rye & Battle Observer, Crawley Observer, Bognor Regis Observer, Mid Sussex Times, Worthing Herald, Littlehampton Gazette, Bexhill-on-Sea Observer, Portsmouth News, Chichester Observer, Midhurst & Petworth Observer, Dundee Evening Telegraph, Aberdeen Evening Express, Independent Recorder, TDNews, BT.com, BreakingNews.ie, The London Economic, The Weekly Observer, The Scientist, The London Economic, Science Magazine, Earth.Com, Independent Recorder, BT.com, Breakingnews.IE, I4U News, Press & Journal, Livekindly.co, Tech Times, IFLScience, Technology Networks Online / Print International: NTN24 (CST Science, Health & Technology Magazine, Latin Americas), Infosurhoy, The Economic Times (India), First Post (India), Eurasia Review, HealthEuropa, Jstor Daily, Times Of India, St Lucia News Online, Times Now (India), Business Standard (India), CanIndia.com (India), Green Report (Italy), New Kerala.com, Fanpage.It (Italy), Le Monde Veterinaire (France) Veterinary / Science-related press: Agri-Pulse, Veterinary Times, Vet Record, Pig World, Feedstuffs, Laboratory Equipment, GlobalMeatNews.com, Animal Pharm, Ag Daily, Agribusiness Intelligence, Laboratory Equipment, Pig Progress, Pig World, Labiotech.EU, MRCVS, Farmweek, National Hog Farmer, Farming UK, Frontline Genomics, Farmers Weekly, Food Weekly News |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/gene-edited-pigs-resistant-billion-dollar-virus |
| Description | Regulation of splicing by the host ubiquitin segregase, VCP/p97, is essential for human cytomegalovirus replication |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | invited seminar at Glasgow Virology Workshop, University of Glasgow . |
| Year(s) Of Engagement Activity | 2016 |
| Description | Research Insights: Science after Dolly |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Research Insights podcast on Science after Dolly. Interdisciplinary presentation on genome editing (for PRRSV resistance) and the ethics around it. Sparking a good discussion on regulation, dysregulation, and ethics. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ed.ac.uk/medicine-vet-medicine/news-events/college-events/research-insights/winter-21-22... |
| Description | Roslin Institute and R(D)SVS stand at Royal Highland Show, Edinburgh, Scotland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stand at the Royal Highland Show with exhibits covering different aspects of research including avian influenza, animal breeding and sheep transcriptomics. |
| Year(s) Of Engagement Activity | 2013,2014,2016,2017 |
| Description | Royal Society Summer Exhibition Flu Fighters exhibit. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participated in Flu Fighters during the Edinburgh Science Festival 2015. We showcased the exhibit 'Flu Fighters' at the festival. The 'Flu Fighters' exhibit focuses on influenza viruses and the science behind the varied approaches to combating flu being developed at Roslin and Pirbright. It showcases current research including GM animals, novel approaches to vaccines and diagnostic tests and host/virus genetics. The exhibit also demonstrates how flu transmits from animals to humans and highlight the challenges of preventing large-scale outbreaks.The 'Flu Fighters' exhibit provides an opportunity for visitors to run diagnostic tests on a chicken, design their own flu virus and discuss the pros and cons of genetic modification of animals. Over 100 people attended the morning and the activities sparked questions from both children and parents/carers. A better understanding of the problem for the poultry industry, eco system (wild birds) and human health was reported back. |
| Year(s) Of Engagement Activity | 2015 |
| Description | School workshop at The Roslin Institute |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | "Cows, coughs and CRISPRs" full day practical workshop introducing 15 pupils from High Schools on the Scottish Mobility Foundation list to the concepts of genome editing and practical aspects molecular biology. The pupils reported not only that they had learned from, and enjoyed the session but that they had also gained an insight into the possibilities open to them in Higher education. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Insights - Outbreak Investigations using Sequence Data |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | For the whole Science Insights programme around 40 pupils intending to apply for university attend Roslin/Easter Bush for 2 days in July. I do an influenza and other viruses sequence analysis workshop for 2-3 hours (once in 2015 and twice in 2016) for 3-4 people per session. |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | Swine Practitioner workshop - France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Key opinion leaders from Asia were invited to discuss advances in PCV2 research including control and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Swine Practitioner workshop - France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Practitioners discussed the pro and cons of control of swine diseases in France. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Swine Practitioner workshop - Italy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | 50-60 practitioners discussed other approached to diagnose and treat infectious disease in pigs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Swine Practitioner workshop - Korea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We discussed novel approaches to diagnose and treat infectious disease in pigs. We also discussed to make a workshop in China which will occur in November 2020 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk at the American Society for Virology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation on "Using precision editing tools and novel pig stem cell technology to generate PRRSV-resistant pigs". Attended primarily by international researchers, but also media, industry, and third sector organisations. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk on genome editing at Newcastle University Animal Science Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Talk on genome editing at the Newcastle University Animal Science Conference 2021. Fantastic discussion on regulation and great interaction with students on the subject. Great feedback and interest in the area. |
| Year(s) Of Engagement Activity | 2021 |
| Description | VGTI, Portland Oregon. ""Discovering novel host-pathogen interactions using systematic approaches" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Was invited to give a presentation at Portland VGTI on our work on Human cytomegalovirus. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit by a group of Co-operative managers from Switzerland |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A group of local area managers from the fenaco group, one of the biggest feed producers and distributers in Switzerland, were visiting the institute to learn about genome editing. Being faced with new breeding technologies they wanted to learn about the advances, the impact, and the future of these technologies in plants and livestock. |
| Year(s) Of Engagement Activity | 2022 |
| Description | dissecting the interferon response to human cytomegalovirus |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar to the Edinburgh infectious disease symposium. |
| Year(s) Of Engagement Activity | 2018 |