Regulation of Metabolic Homeostasis

Lead Research Organisation: Quadram Institute Bioscience
Department Name: Contracts

Abstract

The overall aim of Theme 4 is to provide a mechanistic understanding for the manner by which non-nutrient food and microbiota-derived food metabolites regulate the metabolism of lipids and carbohydrates and modulate overall energy expenditure to maintain and improve health. We will do that by focusing on the two major metabolic organs: the liver, where the transient influx of high concentrations of these metabolites will be exerting ‘first-pass’ effects on lipid and glucose metabolism following their absorption from the gastrointestinal tract, and the organ-associated and peripheral adipocytes, where bioactive compounds can impact on energy sensing and expenditure.
We will use human cell lines but also appropriate animal models to elucidate the role of nrf2 and sirt1 as the mediators of energy metabolism by food and their metabolites. In particular, we will use novel genome editing techniques by CRISPR/Cas9 in human hepatocytes, as well as sirt1 knockdown and overexpressed mouse models, developed in QIB.
In addition, we will undertake human intervention studies with stably labelled fatty acids to enable quantification of hepatic and whole body fatty acid oxidation and lipid synthesis, in response to different diets developed in Theme 1. By combining the results obtained at the cellular and organ levels, we will gain a clear understanding of how diets regulate systemic metabolic homeostasis.

Publications

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Coode-Bate J (2019) Accumulation of Dietary S-Methyl Cysteine Sulfoxide in Human Prostate Tissue. in Molecular nutrition & food research

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Day P (2019) Inhibitors of DAG metabolism suppress CCR2 signalling in human monocytes. in British journal of pharmacology

 
Title Blog on Plant Based Diets health and risk benefits 
Description Wrote a blog published November 2020 on the health benefits and risk of plant based diets. 
Type Of Art Creative Writing 
Year Produced 2020 
Impact More than 1000 views in three months 
URL https://quadram.ac.uk/what-are-the-risks-and-benefits-of-a-plant-based-diet/?fbclid=IwAR2taU82z9VgCW...
 
Description The food-bioactive sulforaphane has shown beneficial effects in regulating liver metabolism. We are investigating the mechanism underpinning the effects of sulforaphane in liver cell metabolism and the potential role of two key cell metabolic regulators NRF2 and SIRT1 as mediators of the effects of sulforaphane on cell metabolism.
Research funded on this grant is improving our understanding on the metabolic consequences of NRF2 and SIRT1 regulation, the interactions between NRF2 and SIRT1 in response to sulforaphane, and their regulatory crosstalk. To date, we have found that sulforaphane regulates energy metabolism through modulating mitochondrial capacity and using C13 glucose-tracing experiments we are looking into the dynamic changes in central metabolic pathways by sulforaphane.

In addition, we have shown that sulforaphane not only activates NRF2 but also upregulates SIRT1 expression in liver immortalised cells and in primary hepatocytes. Preliminary results suggest that when NRF2 is depleted, SIRT1 expression is reduced, suggesting that NRF2 is likely to act up-stream of SIRT1 in the presence of sulforaphane.

Recently, we have shown that polyunsaturated fatty acids are preferentially partitioned to pathways for oxidation compared to saturated fatty acids, i.e. nutrients, specifically fatty acid composition of a meal/diet, influences dietary fatty acid oxidation.
Exploitation Route The results obtained will contribute to improve our understanding on the mechanisms mediating the effects of sulforaphane in human liver metabolism, which is being investigated in this grant within Objective 4. The results will also likely explain some of the underlying mechanisms for other dietary NRF2 -activators that are less well understood.
Sectors Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Novo Nordisk Postdoctoral Fellowship programme
Amount £213,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Novo Nordisk Radcliffe Department of Medicine Postdoctoral Fellowship
Amount £213,500 (GBP)
Organisation University of Oxford 
Department Novo Nordisk – Oxford Fellowship Programme
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description Project grant_CoI
Amount £167,770 (GBP)
Funding ID PG/19/43/34432 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2019 
End 11/2021
 
Title CRISPR/Cas9 
Description Utilsing genome editing CRISPR/Cas9 to Knockout a protein in liver cells 
Type Of Material Cell line 
Year Produced 2020 
Provided To Others? No  
Impact The transfection has been successful and currently assessing downstream consequences. It is still very early days 
 
Title Isotope Tracers 
Description All living organisms utilises sugars such as glucose and amino acids as energy source to produce energy and replicate, in order to survive. Cancer cells in particular are known for there rapid proliferation rates and ability to consume large amount of nutrients. Therefore using isotopic tracers of glucose and amino acids such as Glutamine, along with Gas Chromatography coupled to Mass Spectrometer it is possible to assess and understand how cell lines metabolises these substrates (glucose and amino acids) to get a snapshot of a particular metabolic pathway, when challenged to a compound of interest 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact Using the fully labelled glucose tracer, it has been identified a potential new mechanism on how Sulforaphane a broccoli bioactive may impact cancer development in an in vitro hepatocellular carcinoma cell line 
 
Title RNAsequencin of ESCAPE volunteers 
Description RNAseq of prostate biopsy tissue from prostate cancer patients on active surveillance over 12 months on different diets (ESCAPE trial) 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact This is a n RNAseq dataset of 98 prostate biopsy samples of men that received a dietary intervention. Outcomes were published in Traka et al. AJCN (2019) . The dataset is freely available in ArrayExpress with Accession Number E-MTAB-6525 
URL https://www.ebi.ac.uk/arrayexpress/
 
Description Collaboration with Professor Michael Wormstone from the University of East Anglia 
Organisation University of East Anglia
Department School of Biological Sciences UEA
Country United Kingdom 
Sector Academic/University 
PI Contribution I was provided with samples (cell lysates of lens cells) from a final year PhD student from the University of East Anglia. These lens cells were treated with high doses of Sulforaphane a dietary bioactive found in Broccoli. The aim of the project is to assess whether high does of these Sulforaphane can induce cell death thereby finding potential new treatment for cataracts.
Collaborator Contribution Helped with the analysis. Loading the samples on the Liquid Chromatography Mass Spectrometry Instrument Triple Quad 6490, to identify specific metabolites of interest induced by Sulforaphane. I also then helped to analyse the data
Impact Manuscript is currently being written. Hopefully it will be published the end of 2021
Start Year 2020
 
Description Collboration with Prof Karsten Hiller from Technical University of Braunschweig 
Organisation Braunschweig University of Technology
Department Helmholtz-Zentrum für Infektionsforschung
Country Germany 
Sector Academic/University 
PI Contribution Spent 6 weeks in Germany to utilise methods and instruments that are not available at the Quadram Institute, using labelled isotopes of certain molecules such as glucose and glutamine to understand how the cells metabolize them.
Collaborator Contribution Data Analysis
Impact Brought back from Germany skills on how to conduct this type of assement
Start Year 2019
 
Description Influence of diet on human IBD and the microbiome (Brazil) 
Organisation State University of Campinas
Country Brazil 
Sector Academic/University 
PI Contribution We will provide expertise on the analysis of the microbiome to the study led by our partners.
Collaborator Contribution Our partners have received funding to support the stay of a postdoctoral researcher at the Quadram Institute to develop this research.
Impact no outputs yet
Start Year 2020
 
Description Metabolic Flux analysis in response to dietary sulforaphane 
Organisation Braunschweig University of Technology
Country Germany 
Sector Academic/University 
PI Contribution We have formed this collaboration in order to extend our capabilities in assessing metabolic flexibility of the diet. We have formed a mechanistic hypothesis for the redirection of glucose in liver in response to diet. We are providing the source of the the dietary bioactive, sulforaphane, that will be used to undertake the in vitro experiments to profile metabolites of key metabolic pathways. We also contribute the expertise in dietary modulation of metabolic pathways for the interepretation of the results.
Collaborator Contribution Professor Hiller is the director of the department of Bioinformatics and Biochemistry and will undertake assessment of glucose and glutamine metabolism in repsonse to dietary sulforaphane in hepatocytes. His team will contribute stable-isotope (13C glucose and 13C glutamine) assisted metabolomics by GC-MS to assess metabolic fluxes.
Impact No outputs yet
Start Year 2019
 
Description Polyphenols and energy metabolism in normal and cancer cells 
Organisation Federal University of Rio de Janeiro
Country Brazil 
Sector Academic/University 
PI Contribution The QIB group helped develop high sensitivity LC-MS methods for quantifying anthocyanins and their gut microbiota metabolites in cells and in isolated mitochondria, and through a CAPES-funded postgraduate student placement at QIB, involving one of Dr El Bacha's PhD students, we have shown that absorption and metabolism if polyphenols differs between cancerous and non-cancerous cells, in keeping with differences in effects on energy metabolism. Future developments of this collaboration will involve QIB assessing effects on energy metabolism using the Seahorse platform in order to gain a deeper understanding of the effects on metabolic pathways.
Collaborator Contribution The group of Tatiana El Bacha in the Federal University of Rio have generated data that shows that a particular flavonoid can significantly affect energy metabolism in cancerous cells, but with no effects on non-cancerous cells derived from the same organ. They also obtained funding to support student exchanges/placements and PI travel/subsistence for research visits and workshops in the UK as follows: 1-Programa Jovem Cientista do Nosso Estado grant number E-26/201.571/2014 funded by Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)-Brazil; 2- Newton Advanced Fellowship grant number RG80003 funded by Academy of Medical Sciences-UK; 3- Programa de Doutorado Sanduíche no Exterior (PDSE) process number 88881.134471/2016-01, funded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Impact 1. Postgraduate student placement funded under the Brazilian CAPES scheme. 2. Method for quantifying flavonoids/microbiota-derived metabolites in isolated mitochondria samples. 3. Workshop report from 1st Workshop in Rio de Janeiro, Brazil.
Start Year 2016
 
Title ADAPT study 
Description The study was pilot study assessing what impact would a high dose of Sulphur compound from Broccoli (Sulforaphane) and one in Garlic (Alliin) have on prostate cancer progression. Men with prostate cancer were recruited and split into four groups: two placebo which acted as the respective control, the group that received Sulphur compound in Broccoli and the other group received the Sulphur compound in Garlic. Prostate tissues was then extracted and samples were sent for RNAsequencing. Analysis is still currently taking place. 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2020
Development Status Under active development/distribution
Impact Data is still being currently analysed. It is hoped that the data will be written in a manuscript and will be published. 
 
Title BOBs clinical trial 
Description A food product that deliver physiological active concentrations of the bioactive sulforaphane to the systemic circulation 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2016
Development Status Actively seeking support
Clinical Trial? Yes
Impact A food products that has been shown to deliver physiological active levels of the bioactive compound sulforaphane to the systemic circulation 
URL https://clinicaltrials.gov/show/NCT023300324
 
Title ESCAPE clinical trial 
Description A novel food products that delivers high levels of the bioactive compound glucoraphanin in a food matrix that inhibits changes in gene expression in prostate tissue that are associated with cancer progression 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2018
Development Status Actively seeking support
Clinical Trial? Yes
Impact The products is being developed through a spin out company 
URL https://clinicaltrials.gov/show/NCT01950143
 
Title FAMOUS clinical trial 
Description A clinical trial is being planned to assess the effect of sulforaphane on fatty acid beta oxidation. Volunteers will consume sulforaphane/placebo supplements for three weeks and then consume 13C labelled fatty acid. 13C CO2 will be quantified in their breath as a marker of fatty acid oxidation 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Initial development
Year Development Stage Completed 2019
Development Status Under active development/distribution
Impact N/A 
 
Title SAP clinical trial 
Description A food product that delivers high levels of the bioactive compound S-methylcysteine sulfoxide which accumulates in prostate tissue of men with organ confined prostate cancer 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2018
Development Status Actively seeking support
Clinical Trial? Yes
Impact A food product that delivers S-methyl cysteine sulfoxide that accumulates in prostate tissue and may reduce risk of aggressive prostate cancer. A patent has been filed. 
URL https://clinicaltrials.gov/show/NCT02821728
 
Company Name THE SMARTER FOOD COMPANY LIMITED 
Description This is a spin out company from based upon intellectual property from the Food and Health ISP and the Food Innovation and Health ISP. 
Year Established 2018 
Impact The company has recently been established. It has received investment from private equity funds an a grant from Innovate UK. It s currently engaged with developing food products that will enter clinical trials towards end of 2019
 
Description Engagement with PepsiCo: Modification of carbohydrate quality in cereals and its consequences for digestion and metabolism 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Functional foods characterisation and development: Mechanical processes controlling digestion of food structures and subsequent nutrient release
Year(s) Of Engagement Activity 2020
 
Description 'Heroes of Food Research' Public Engagement activity 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The purpose of the set of activities was to engage in a dialogue with members of the public in the region where we recruit participants to partake in dietary intervention studies. The activities included two sessions in Norwich's Forum Library public space where visitors could read about the types of studies that were going on, discuss what was involved when volunteering to participate in a study, ask questions of study PIs and study managers, taste intervention foods, complete a short questionnaire, and sign up for future activities which included an evening session with audience participation and voting and a workshop to gather feedback from potential volunteers. As a result of the activities and the significant feedback from the general public and those who had previously participated in human studies, we completely revamped our institute's Human Studies internet pages, recorded feedback and subsequently changed various features of our adverts that invited people to participate in specific studies, and recruited a significant number of new people to our database of interested volunteers.
Year(s) Of Engagement Activity 2015,2016
URL https://quadram.ac.uk/volunteer/
 
Description A talk in workshop on utilising stable-isotope methodologies to assess human metabolism 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact 50 researchers attended a nutrition society workshop on the utilisation and application of stable-isotope tracers tin human nutrition research which reaised a lot of interesting discussion
Year(s) Of Engagement Activity 2020
URL https://www.nutritionsociety.org/events/application-stable-isotope-techniques-human-nutrition-resear...
 
Description Bioavailability 2018 International Conference, 'Understanding the bioavailability of micronutrients and bioactive compounds for improved public health', the 8th in the series of Bioavailability conferences. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Bioavailability 2018 International Conference, 'Understanding the bioavailability of micronutrients and bioactive compounds for improved public health', the 8th in the series of Bioavailability conferences.
Year(s) Of Engagement Activity 2018
 
Description Blog on Polyphenols and cardiovacsular health 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Describing beneficial effects of polyphenols on cardiovascular health
Year(s) Of Engagement Activity 2021
URL https://quadram.ac.uk/blogs/polyphenols-chocolate-apples/
 
Description CCG representatives visit to discuss collaborative opportunities for food and health research 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact CCG representatives visit to discuss collaborative opportunities for food and health research
Year(s) Of Engagement Activity 2019
 
Description Colonic transformation of anthocyanins is partly spontaneous and partly driven by the gut microbiota 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact PhD Student Emad presented a poster
Year(s) Of Engagement Activity 2021
 
Description Cool Food Facts - primary school BIO outreach event in Lowestoft 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Lowestoft primary school requested the activity for the science day to the School of Biology, UEA (contact - Carl Harrington). The session ran 4 times for Yr2 to Yr6, with approximately 30 students in each session.
Year(s) Of Engagement Activity 2018
 
Description Deciphering the extent to which choline and carnitine are partitioned between the gut microbiota and the host using an in-vitro human colon model 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presented at the Cambridge metabolic networking workshop (Oral)
Year(s) Of Engagement Activity 2019
 
Description Engagement with government 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Understanding how research and policy interact and identify gaps in the diabetes research that need to be addressed. Understanding NHS long term and short programme for diabetes prevention and care Discussing funding opportunities for diabetes research
Year(s) Of Engagement Activity 2019
 
Description Engagement with other research organisations and HEIs 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Business Development
Year(s) Of Engagement Activity 2020
 
Description Evidence on the front of pack nutrition labelling: Provided expert consultation to The Physiological Society 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Provided in support of The Physiological Society's response to the Government's consultation on the multiple traffic system for front-of-package labelling.
Year(s) Of Engagement Activity 2020
 
Description Exploring food and health 2 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Q&A panel to discuss with the girls (various schools aged 15/16) about her role and the career pathway to it
Year(s) Of Engagement Activity 2020
URL https://youtu.be/1iXE85g03RQ
 
Description FDNC & FIH School Activity - Clever Food Trail session with primary school children 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Visited Hethersett Primary School to speak and provide a number of activities on the clever food trail.
Year(s) Of Engagement Activity 2020
 
Description Hosted a Visit to Quadram Institute of SR, Director of Scientific Programmes at the Physiological Society 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Formal discussion on the incorporation of the microbes in Physiology as a research theme and future interaction between the QIB and the Physiological Society.
Year(s) Of Engagement Activity 2020
URL https://www.physoc.org/events/physiology-2021/#tab-02
 
Description In2Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a talk and had a discussion about careers in science
Year(s) Of Engagement Activity 2018
 
Description International Clinical Trial Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact International Clinical Trial Day
Year(s) Of Engagement Activity 2019
 
Description Membership of a Panel or Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Member of the assessment panel scoring proposals submitted to the BBSCR GCRF 'Combined Food Systems Approach to Scaling-up Interventions to Address the Double Burden of Malnutrition (DBM)'.
Year(s) Of Engagement Activity 2021
 
Description North West Science Network Launch Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact I was the keynote speaker at the launch of the North West Science Network for 2018 - I gave a presentation about my career, my science and there was a discussion about careers in science.
Year(s) Of Engagement Activity 2018
 
Description Norwich Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact QIB activity tables and art exhibition
Year(s) Of Engagement Activity 2019
 
Description Norwich Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Norwich Science Festival
Year(s) Of Engagement Activity 2018
 
Description Norwich Science Festival - QIB activity tables and art exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Links to media articles and NSF summaries Hands on activities, games and crafts at the NRP day of the NSF 2019.
Year(s) Of Engagement Activity 2019
 
Description Norwich Science Festival: Clever Food Stall 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Welcome posters, Research posters, EatWell Guide Poster, Clever Food Trail, Recipe cards, Certificates, Landyards, Stickers, Smelling jars
Year(s) Of Engagement Activity 2019
 
Description On the 2nd of July the Quadram Institute of Biosciences (Norwich UK) hosted the event organised from the IFST, by streaming the lecture given by Professor Michael Gibney, Emeritus Professor of Food and Health from University College Dublin 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The event was organised from Federico Bernuzzi and Dr Anabel Mulet Cabero from the Quadram Institute of Biosciences (QIB), in partnership with the IFST Eastern Branch. 25 people attended the lecture, mainly staff from the QIB but also several additional employers across the Norwich Research Park and additional companies across Norfolk. Prior to the lecturer Dr Jennifer Ahn-Jarvis a Research Scientist from the QIB, gave a 30-minute lecture on her Post-Doctoral Followership work at Ohio State University. The event ended with a 1hour networking session, were cold food and drinks was provided. This year's event had the largest number of attendees, compared to previous years and the feedback that was provided was that it was very well organised, and both talks were well received
Federico Bernuzzi got in touch with Dr Patricia Hart to ask whether the Quadram could host the event. He then organised the speaker. Dr Mulet Cabero instead sorted out the advertisement, by publishing information on the Quadram news and was in charge of the catering
Year(s) Of Engagement Activity 2019
 
Description Polyphenol enriched tomatoes protect against atherosclerotic plaque development in ApoE-/- mice by modifying cholesterol efflux and inflammation Future Physiology (The Physiological Society) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Presented a poster at the Future Physiology Conference
Year(s) Of Engagement Activity 2020
 
Description Public Engagement at the Royal Norfolk Showground on the 26th of June 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Teaching the public the health benefits of dark chocolate, blueberries and broccoli. For the kids an activity was given them to do. Three different pots that had dark chocolate, broccoli and blueberries and the kids had to smell and guess the compounds
Year(s) Of Engagement Activity 2019
 
Description Reepham Food Festival - Fun Food Science Activity 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Reepham Food Festival - Fun Food Science Activity
Year(s) Of Engagement Activity 2018
 
Description Regulation of mitochondrial bioenergetics by the food-derived bioactive sulforaphane through activation of NRF2 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Selected oral presentation for the Nutrition and Genomic (NuGO) Annual Conference
Year(s) Of Engagement Activity 2018
URL http://www.nugo.org/
 
Description Royal Norfolk Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal Norfolk Show
Year(s) Of Engagement Activity 2019
 
Description School Visit (Hethersett Primary School) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Attended a morning at a local primary school in Hethersett Norwich. 60 pupils were split into five different groups. Five different stations were set up and each station represented different food nutrients such as carbohydrates, protein,fats. The aim of the activity was to teach the children which foods had those particular nutrients whether health choices could be chosen to ultimately improve their health style.
Year(s) Of Engagement Activity 2020
 
Description School Visit (Hethersett, Norwich) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We designed an activity for Year 4 students, called 'the Smell Test', in order for the students to learn about the different phytochemicals within fruits and vegetables that are associated with helath benefits and have a strong odour. We linked the activity with the curriculum of Year 4 students at the time, which was on 'teeth and digestion' and introduced the students to basic concepts of digestion. We captured impact by asking students to report what they learned at the end of the session, which indicated an overwhelmingly positive response and acquisition of new knowledge around diet and health.
We were also asked to undertake further activities from the school.
Year(s) Of Engagement Activity 2018
 
Description Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Provided a talk about my career in science and also about my research to school students thinking of coming to university.
Year(s) Of Engagement Activity 2018
 
Description Talk to stakeholders in WSRO 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Provided an update on the current literature and science around sugar and health
Year(s) Of Engagement Activity 2018
 
Description The interplay between plant, human and microbial sulphur metabolism in the prevention of aggressive prostate cancer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation - The interplay between plant, human and microbial sulphur metabolism in the prevention of aggressive prostate cancer
Year(s) Of Engagement Activity 2018
 
Description The role of 3,4-dihydroxyphenyl-y-valerolactone, the gut microbiota metabolite of (-)-epicatechin, in reducing insulin resistance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Kobe, Japan. 27th Nov - 2nd Dec. International conference on polyphenols and health
Year(s) Of Engagement Activity 2020
 
Description Tomatoes expressing specific polyphenols reduce atherosclerotic plaque size in ApoE mice via the modification of inflammation and reverse cholesterol transport 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Norwich Institute for Healthy Ageing (NIHA) Initial Partner Symposium
Year(s) Of Engagement Activity 2020
 
Description Transcriptional changes in prostate of men on active surveillance following a 12-month glucoraphanin-rich broccoli intervention - results from the ESCAPE study 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact PRESENTATION - Transcriptional changes in prostate of men on active surveillance following a 12-month glucoraphanin-rich broccoli intervention - results from the ESCAPE study
Year(s) Of Engagement Activity 2018
 
Description UEA Co-creation Sandpit Event - Innovation, Health and Well-being 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact There were 70 participants and several teams developed and pitched ideas. Each team involved participants from different background, with a good balance between industry, policy makers, healthcare workers, social scientists, nutritionists etc. Project development and further applications for funding are encouraged. A linked in page has been set up for further networking https://www.linkedin.com/groups/8991208/
Year(s) Of Engagement Activity 2020
URL https://www.linkedin.com/groups/8991208
 
Description Unilever visit 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Unilever visit - a series of talks were presented to Unilever on a health microbiome, personalised nutrition and individual differences in the microbiome and gut brain axis. Unilever then met with group leads from QIB in one to one sessions.
Year(s) Of Engagement Activity 2020
 
Description Visit by Waitrose. 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact To present the research of QIB to representatives of the Waitrose Nutrition and Technology elements.
Year(s) Of Engagement Activity 2019
 
Description We attended a speed networking event for pupils in year 12 at Wymondham Sixth Form College. This involved talking about our career trajectories, what we do as scientists on a day to day basis and importantly the important work being carried out here at the Quadram Institute. Students were keen to hear more about the interaction of food and the gut microbiota and their influence to health. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Speed networking event for pupils in year 12 at Wymondham Sixth Form College
Year(s) Of Engagement Activity 2019
 
Description What are the risk and benefits of a plant based diet? 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact PhD Student Federico Bernuzzi wrote the blog to explore the "risks and benefits" that should be considered by anyone considering a move to a diet containing less or no meat.
Year(s) Of Engagement Activity 2020
URL https://quadram.ac.uk/what-are-the-risks-and-benefits-of-a-plant-based-diet/
 
Description Whodunnit? Teasing apart the effects of ingested polyphenols versus their gut microbiota metabolites 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 9th International Conference on Polyphenols and Health
Year(s) Of Engagement Activity 2019
 
Description Women of the future online Panel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Career advice to women of the future in science
Year(s) Of Engagement Activity 2020
 
Description Year 10 UEA Summer School Protein Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This session enabled students to understand the concept of protein biochemistry and basic bioinformatics by use of online free available software.
Year(s) Of Engagement Activity 2019
 
Description speed networking event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We attended a speed networking event for pupils in year 12 at Wymondham Sixth Form College. This involved talking about our career trajectories, what we do as scientists on a day to day basis and importantly the important work being carried out here at the Quadram Institute. Students were keen to hear more about the interaction of food and the gut microbiota and their influence to health.
Year(s) Of Engagement Activity 2019