Virus-host interactions of peste des petits ruminants virus (PPRV)

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

Peste des petits ruminants virus (PPRV) causes a significant disease in sheep and goats, the mainstay of subsistence farming in the developing world. PPRV has spread rapidly in the last twenty years and is now found from Morocco to China and from Turkey to Ethiopia. Its continued presence in the developing world and its devastating impact on the poorest farmers has strengthened the calls for a concerted eradication campaign. However little is still known about this virus highlighting the need for continued and focused investigation. The aim of the PPRV research fellowship at the IAH is to develop a fundamental understanding of the interactions that take place between this pathogen and its host during infection. Using techniques such as affinity tag purification to identify cellular factors and complexes involved in viral replication will provide detailed information about this economically significant disease of sheep and goats. In addition developing a better molecular understanding of PPRV will provide important and relevant information about pathogenesis, viral tropism and methods of rational attenuation. We are also developing the tools to undertake more wide-scale systems biology based analysis of PPRV infection.

Publications

10 25 50
 
Description Identification of host cell receptors for PPRV. This knowledge helps us to understand why PPRV only causes disease in goats and sheep, by showing that this is not a preference for the goat/sheep receptor, and therefore other areas must be researched.
Exploitation Route This is not clear. PPRV is primarily an are for applied virology, rather than basic molecular biology/proteomics.
Sectors Agriculture, Food and Drink

 
Description No significant industrial or public policy impact.