Generation of molecules, tools and reagents for pathogen recognition, antigen presentation and effector responses in avians
Lead Research Organisation:
The Pirbright Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
A detailed understanding of how avians respond to pathogens and vaccines is limited by incomplete knowledge of the molecular, cellular and anatomical components of an immune system that differs between birds and widely-studied biomedical species. The aim of this proposal is to generate tools, reagents and assays and use them to elucidate aspects of the immune system that will give a fuller understanding of basic processes and the ability to elicit more rapid, efficacious and sustainable immunity to pathogen challenge.
Planned Impact
unavailable
People |
ORCID iD |
| Venugopal Nair (Principal Investigator) |
Publications
Biggs P
(2012)
The long view: 40 years of Marek's disease research and Avian Pathology
in Avian Pathology
Chappell P
(2015)
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.
in eLife
Ciccone NA
(2014)
A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels.
in Veterinary research
Mullarkey C
(2013)
Improved adjuvanting of seasonal influenza vaccines: Preclinical studies of MVA-NP+M 1 coadministration with inactivated influenza vaccine
in European Journal of Immunology
Parker A
(2012)
Chicken class II DMA and DMB are similar to mammals, but a second DMB gene differs in expression level, regulation and structural features
in Molecular Immunology
Payne LN
(2012)
The long view: 40 years of avian leukosis research.
in Avian pathology : journal of the W.V.P.A
Salomonsen J
(2014)
Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.
in PLoS genetics
Staines K
(2014)
Evolution of an expanded mannose receptor gene family.
in PloS one
| Description | We have developed tools for understanding specific immune responses and the cells that generate them. These include the development of reagents against the chicken immune checkpoint regulatory molecules chPD-1 and chPD-L1. This unique set of reagents are valuable tools for the development of potential tools for treatment of chronic diseases including neoplastic diseases such as Marek's diseases. |
| Exploitation Route | These tools will be of value in the design of new vaccines and the testing of their effectiveness. |
| Sectors | Agriculture Food and Drink Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Findings have been used in the trial of new vaccines. |
| First Year Of Impact | 2013 |
| Sector | Agriculture, Food and Drink |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £440,000 (GBP) |
| Funding ID | BB/R007896/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | Innovations in control of avian infectious diseases for sustainable growth and food security in low and middle income countries |
| Amount | £355,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 11/2021 |
| Description | Recombinant MDV vaccine expressing gRNA targeting REV using CRISPR/Cas9 system to prevent MDV and REV infection |
| Amount | ¥120,000 (CNY) |
| Funding ID | SKLVBF201605 |
| Organisation | State Key Laboratory of Veterinary Biotechnology |
| Sector | Public |
| Country | China |
| Start | 01/2016 |
| End | 12/2017 |
| Title | CRISPR/Cas9-based gene editing pipeline for generation of recombinant herpesvirus vaccines or targeted editing |
| Description | CRISPR/Cas9-based gene editing pipe line was established for rapid generation of recombinant herpesvirus vaccines, which involves the use of stable Cas-9 expressing cell lines or through transient Cas9 expression |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The major impact of this will be enabling advanced research in developing new innovative vaccines for successful and effective control of avian diseases for enhancing global food security |
| URL | https://www.jove.com/video/58193/generating-recombinant-avian-herpesvirus-vectors-with-crisprcas9-ge... |
| Description | Avian Vaccines Malaysian Researchers |
| Organisation | Putra Malaysia University |
| Department | Department of Pathology |
| Country | Malaysia |
| Sector | Hospitals |
| PI Contribution | We have successfully organized a British Council funded workshop on Emerging and Next Generation Vaccine Technologies Against Veterinary Viruses at Institute of Bioscience (IBS), Universiti Putra Malaysia from 01 to 04 August 2016. |
| Collaborator Contribution | Through this partnership, we have applied two research grants to work together in tackling infections in poultry. |
| Impact | Two Funding Applied One Publication Online |
| Start Year | 2016 |
| Description | Global Alliance for Research on Avian Diseases |
| Organisation | Global Alliance for Research on Avian Diseases |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | This alliance led by Pirbright has participation from over 40 countries and comprises of academics and industry professionals. This forum helps in working together, identifies the challenges and opportunities for improved control of avian diseases |
| Collaborator Contribution | Two successful international meetings were organised as part of this alliance, one in London in 2015 and most recent one in Hanoi, Vietnam in January 2018 |
| Impact | Organisation of two successful international meetings and development of significant collaborations |
| Start Year | 2015 |
| Description | AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro... |
| Description | Avian Genetics and Immunity (University of Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The Symposium on Avian Genetics and Immunity is being to engage international audience with interests on avian genetics and immunity |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://geneticsandimmunity.com |
| Description | Chaired the Poultry Disease group meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry Disease group is a forum of veterinary practitioners to discuss the advances in poultry diseases that could be translated from research labs to the farms |
| Year(s) Of Engagement Activity | 2017 |
| Description | Interview for CGTN on the importance of poultry disease control in China and the significance of collaboration |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | It was an interview by the editor for CGTN on the contribution of Pirbright and the Chinese collaborations on controlling poultry diseases and improving avian health |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://newseu.cgtn.com/news/2020-01-28/British-and-Chinese-scientists-join-forces-to-fight-avian-di... |
| Description | Poultry Health Course (Pirbright) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The course is organised for participants from Brazil to understand the current advances in poultry diseases. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.poultryhealthcourse.com/ |
| Description | UK-Malaysia Vaccinology Workshop (Malaysia) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop aimed to build long-term and sustainable links between scientists in the UK and Malaysia working on/have interests in veterinary vaccines. This workshop has encouraged early career researchers from veterinary, biological and social sciences to understand the ever-increasing threats to global food security from infectious animal diseases and their control using next generation vaccine strategies. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://ukmalaysiaworkshop.co.uk/ |