Developing genetic control methods for arthropod vectors
Lead Research Organisation:
THE PIRBRIGHT INSTITUTE
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Arthropod pests transmit or vector viral pathogens causing morbidity, suffering and economic harms to animals and humans. The best known such arthropod vectors may be mosquitoes, but mites and ticks, as well as other insects, are also significant disease vectors. We aim to develop new genetics-based control tools to supplement and complement existing control methods. We can use the natural propensity of the pest arthropod to seek out and mate the opposite sex as the basis for highly specific control methods targeted on the pest arthropod with minimal off-target effects. We focus on two broad approaches, aiming either (i) to reduce the numerical size of the pest population – “population suppression”, also the aim of most conventional approaches such as the use of insecticidal chemicals or (ii) to reduce the ability of the mosquito to transmit a specific pathogen, or set of pathogens. We are also exploring ways to introduce such genes into target pest populations. In each case we take a synthetic biology approach, with systematic laboratory development combined with mathematical modelling.
Planned Impact
unavailable
Publications
Alphey L
(2016)
Can CRISPR-Cas9 gene drives curb malaria?
in Nature biotechnology
Alphey L
(2016)
SIT 2.0: 21(st) Century genetic technology for the screwworm sterile-insect program.
in BMC biology
Concha C
(2016)
A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique.
in BMC biology
Edgington MP
(2017)
Conditions for success of engineered underdominance gene drive systems.
in Journal of theoretical biology
Gregory M
(2016)
Insect transformation with piggyBac: getting the number of injections just right.
in Insect molecular biology
Harvey-Samuel T
(2017)
Towards the genetic control of invasive species.
in Biological invasions
| Description | This award represents one year of a component of an Institute Strategic Programme Grant (ISPG) to The Pirbright Institute. This element relates to the conceptual and laboratory development of genetic pest management methods for mosquitoes and other pest insects, including gene drive methods. This research laid the foundation for further work, both within this ISPG and elsewhere, on locally-acting gene drive systems in mosquitoes and other pest insects. |
| Exploitation Route | Genetic pest management is a rapidly advancing field, and our work in this area is used both to develop technical resources and to inform policy and regulation. Based on this underpinning work we now participate in two international consortia aimed at further development of such systems. |
| Sectors | Agriculture Food and Drink Environment Healthcare Manufacturing including Industrial Biotechology |
| Description | This award represents one year of a component of an Institute Strategic Programme Grant to The Pirbright Institute. This element relates to the conceptual and laboratory development of genetic pest management methods for mosquitoes and other pest insects, including gene drive methods. Our work in this area has contributed to policy development in this relatively new area, stimulated by our work in this area and informed by our research findings. Specific aspects of this include involvement as a Nominated Expert in the Open-ended Online Forum on Synthetic Biology of the Cartagena Protocol on Biodiversity (CBD), and as a Member of the Technical Subgroup on Synthetic Biology and Biodiversity Conservation of the International Union for the Conservation of Nature (IUCN), in various aspects of policy development. We have also helped the Institute's communications group develop a outreach event around gene editing and modified mosquitoes, which has been used at a number of regional and national public events, including GLive (Guildford) and the Royal Institution, to stimulate awareness, understanding and discussion of this type of technology. |
| First Year Of Impact | 2017 |
| Sector | Education,Environment |
| Impact Types | Societal Policy & public services |
| Description | RCUK Engagement workshop, Cosener's House, 20-21 April 2017 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | DARPA PREEMPT |
| Amount | $2,700,000 (USD) |
| Organisation | Defense Advanced Research Projects Agency (DARPA) |
| Sector | Public |
| Country | United States |
| Start | 09/2018 |
| End | 03/2022 |
| Title | Additional file 1: of A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique |
| Description | Female lethality data for C. hominivorax FL11 and FL12 homozygous lines. (XLSX 38 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_A_transgenic_male-only_str... |
| Title | Additional file 1: of A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique |
| Description | Female lethality data for C. hominivorax FL11 and FL12 homozygous lines. (XLSX 38 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_A_transgenic_male-only_str... |
| Title | Additional file 1: of Identification of genes for engineering the male germline of Aedes aegypti and Ceratitis capitata |
| Description | Sequencing and alignment statistics. Table of sequencing and alignment statistics. (XLSX 47Â kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Identification_of_genes_fo... |
| Title | Additional file 1: of Identification of genes for engineering the male germline of Aedes aegypti and Ceratitis capitata |
| Description | Sequencing and alignment statistics. Table of sequencing and alignment statistics. (XLSX 47Â kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Identification_of_genes_fo... |
| Title | Additional file 2: of A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique |
| Description | Female lethality data for C. hominivorax FL11 and FL12 heterozygous lines. (XLSX 36 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_A_transgenic_male-only_str... |
| Title | Additional file 2: of A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique |
| Description | Female lethality data for C. hominivorax FL11 and FL12 heterozygous lines. (XLSX 36 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_A_transgenic_male-only_str... |
| Title | Additional file 2: of Identification of genes for engineering the male germline of Aedes aegypti and Ceratitis capitata |
| Description | Candidate genes tested experimentally. Tables of candidate Ae. aegypti and C. capitata testis-specifically expressed and testis-specifically spliced genes tested experimentally. (XLSX 42Â kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Identification_of_genes_fo... |
| Title | Additional file 2: of Identification of genes for engineering the male germline of Aedes aegypti and Ceratitis capitata |
| Description | Candidate genes tested experimentally. Tables of candidate Ae. aegypti and C. capitata testis-specifically expressed and testis-specifically spliced genes tested experimentally. (XLSX 42Â kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Identification_of_genes_fo... |
| Description | Outreach Network for Gene Drive Research |
| Organisation | Outreach Network for Gene Drive Research |
| Sector | Charity/Non Profit |
| PI Contribution | Input to policy discussions |
| Collaborator Contribution | Network is engaged in briefing national and international entities, e.g. EU/EC, European Parliament, IUCN, Convention on Biological Diversity, on issues related to gene drive. Outreach also relates to general public (directly and via media) as well as policymakers, regulators and practitioners. The Pirbright Institute is now a member of the Network |
| Impact | Briefing and media comment regarding gene drives and gene drive research to multiple agencies e.g. EU/EC, European Parliament, IUCN, Convention on Biological Diversity, on issues related to gene drive. |
| Start Year | 2019 |
| Description | Ash Manor GCSE Mentoring 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC Today programme 24/01/2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview on BBC Today programme regarding potential development and use of gene drives in mice |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/sounds/play/m00025bt |
| Description | BBSRC talk 20-02-2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Gave lunchtime seminar at BBSRC, Swindon, primarily for BBSRC staff. On genetic control of GM mosquitoes and moving technology from idea to lab to field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | BIotech YES 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a talk at the BBSRC Biotechnology Young Entrepreneurs' Scheme event at Syngenta (Jealott's Hill) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Big Bang Fair South East - RC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science festival/event - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Biotech YES, Syngenta Jealott's Hill, 05 Oct 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Teams of postgraduate students from a number of universities and institutes attended talk as part of Biotech YES (Young Entrepreneurs' Scheme). Follow-up discussion influenced several aspects of their approach to entrepreneurship both within the competition and more generally |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
| Description | CBD Open-ended online forum on synbio 06-10/2017 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | UN Convention on Biodiversity. Policy- discussion on synthetic biology: nominated participant in the Open Ended Online Forum on Synthetic biology as established in decision XII/24 of the Conference of the Parties to the Convention on Biological Diversity (COP) and extended in COP decision XIII/17 which ran from June to Oct 2017 (approx.) |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://bch.cbd.int/synbio/open-ended/discussion/ |
| Description | CNN interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with CNN journalist. Journalist later followed up asking me to check and clarify some issues. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Camberley Library Fun Palace 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Speak and participate in panel discussion on potential use of GM insects |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cheltenham Science Festival 2018 - JA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major national science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - RC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - SV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Display at major science festival: changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018-DP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major national science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | DARPA visit April 2017 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Hosted visit by US funding agency programme manager to The Pirbright Institute |
| Year(s) Of Engagement Activity | 2017 |
| Description | Diego Friere Pesquisa Fapesp |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with journalist leading to article regarding release of transgenic mosquitoes into the environment to control dengue and other diseases |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://revistapesquisa.fapesp.br/en/2020/02/05/jacobina-controversy/ |
| Description | Discuss gene drives with NZ Parliamentary Commissioner |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Met NZ Parliamentary Commissioner to provide background information on, and discuss, gene drive systems. New Zealand is considering genetic and other control methods for invasive pests. |
| Year(s) Of Engagement Activity | 2018 |
| Description | EPO TalkInnovation Facebook live event and podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | EPO TalkInnovation Facebook live event and podcast discussing use of genetic methods to control mosquitoes and mosquito-borne disease |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.facebook.com/europeanpatentoffice/videos/a-minute-change-that-makes-a-massive-difference... |
| Description | Edinburgh Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and panel event at Edinburgh Science Festival "The Buzz about GM Insects". Sparked questions and discussions afterwards including some career questions. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gene Drive Resarch Sponsors and Supporter's Forum meeting Montreal Sept 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Forum met to discuss the state of the art and future considerations for gene drive research. Ongoing deliberations including specific follow-up meetings. |
| Year(s) Of Engagement Activity | 2018 |
| Description | IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation (meeting 12-15 April and report) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Participated as member in Technical Subgroup on Synthetic Biology and Biodiversity Conservation of International Union for Conservation of Nature (IUCN). Meetings, online discussion and ultimately a report to Task Force and will ultimately go to IUCN General Assembly. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Innovate Guildford 17 March 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and exhibit at Innovate Guildford - >100 for talk, probably >500 for exhibit. Both sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave open talk at Innovate Guildford; 50-60 audience with wide age range, many questions and lively debate |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science/innovation event - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 - SB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 - SV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Display at regional science/innovation festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at UC Riverside 05/05/2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at University of California, Riverside |
| Year(s) Of Engagement Activity | 2017 |
| Description | Katherine Coe, press4kids, 2016 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Helped journalist develop article delivered by phone app for schools/school-age children explaining mosquitoes, mosquito-borne disease and the possibility of controlling these by use of modified mosquitoes |
| Year(s) Of Engagement Activity | 2016 |
| Description | NIAID PPC/TPP meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | NIAID workshop on Preferred Product Profile / Target Product Profile definitions and use for genetic vector management products |
| Year(s) Of Engagement Activity | 2020 |
| Description | Nick Rufford, Sunday Time Mag, published 27/08/2017 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided information and quotes for Sunday TImes Magazine article on GM mosquitoes and Zika |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.thetimes.co.uk/article/how-genetically-engineered-mosquitoes-will-save-lives-kwc8nmwh5 |
| Description | Princess Anne opening Jenner |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Princess Anne, entourage, local politicians and dignitaries visited to open new research building. I was one of small number asked to present/demonstrate/describe our research work, which is on genetic modification of mosquitoes to provide new tools with which to help control mosquito-borne viral diseases. |
| Year(s) Of Engagement Activity | 2017 |
| Description | RSB Animal Science Group Sept 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated in RSB Animal Science special-interest group discussion on development of gene drives. |
| Year(s) Of Engagement Activity | 2018 |
| Description | RSB Genetic Tech Governance Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Workshop hosted by the Royal Society of Biology (RSB) on the use of genetic technologies and the governance and regulation of organisms developed by genetic modification, genome editing and other breeding methods |
| Year(s) Of Engagement Activity | 2019 |
| Description | Respond to SMC enquiry re gene drives in mice |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Responded to Science Media Centre request for expert comment on a scientific paper regarding gene drives in mice. Quoted in The Independent |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.independent.co.uk/news/science/gene-editing-dna-technology-mice-pests-drives-invasive-sp... |
| Description | Respond to SMC request re Vosshall paper 08 Feb 2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Respond to SMC request re scientific paper describing behaviour-altering drugs in mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Institution Christmas Lectures Family Day - LA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Six Pirbright staff/students ran an all-day exhibit on gene editing and mosquitoes at the Royal Institution About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Institution Christmas Lectures Family Day - SB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Society of Biology Biology week talk, Winchester, 10/10/2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk organized by Royal Society of Biology as part of Biology Week. This one in Winchester, audience was general public with strong representation of school-age. Questions and discussion during and after formal talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | STEM Day - Speed interviews and Careers Day 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk to clinicians at Hospital for Tropical Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to clinicians at Hospital for Tropical Diseases, London, regardingcurrent and future methods for controlling mosquito-borne disease based on mosquito genetics |
| Year(s) Of Engagement Activity | 2020 |
| Description | Tillingbourne Bug Hunt |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Local entomology event for general public - changes in public attitudes and stimulating increased interest in insects/entomology and research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Tillingbourne Year 3 Science Day 2018 - EL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Wired interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media interview regarding use of gene drive systems in mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.wired.co.uk/article/genetically-modified-mosquitoes-gene-drive |
| Description | email interview with journalist (Sukanya Charuchandra, The Wire) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Email interview for journalist for "The Wire" - an online technology-focused media outlet. Helped provide context and impact for the resulting piece. https://thewire.in/the-sciences/scientists-identify-protein-that-mosquitoes-need-to-lay-viable-eggs |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://thewire.in/the-sciences/scientists-identify-protein-that-mosquitoes-need-to-lay-viable-eggs |
| Description | international workshop on "Self-Propagation of Artificial Genetic Elements: Gene Drives, Risks & Tipping Points Bremen 19-20 June 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Workshop considering regulatory, social and technical environment for gene drive systems in insects, primarily for German and other EU regulatory and political entities. |
| Year(s) Of Engagement Activity | 2018 |