High Containment

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

The Pirbright Institute is a front-line national capability in the response to incursions of exotic viral pathogens in the UK and is a key player in worldwide research of methods to predict, detect and control outbreaks of disease. To achieve this vital role there is a requirement to provide infrastructure and highly specialised expertise across a variety of disciplines, underpinning the science outlined in the institute’s new BBSRC Institute Strategic Programme Grants (ISPG). The primary high containment facilities at The Pirbright Institute are the Animal Isolation units, which enable studies of viral infection in natural ruminant hosts (cattle, sheep, pigs, goats) and the Plowright building, a state of the art laboratory facility housing opened in 2015. These facilities enable studies to be carried out on the most infectious viral diseases of animals known, including foot and mouth disease virus and African swine fever virus. In addition, the Plowright Laboratory is also increasingly used in the study of zoonotic viruses and those that are transmitted between humans by insect vectors. This broadening of research scope is a key aspect to strategic planning and reflects an increasing integration between medical and veterinary research at the site.

Organisations

Publications

10 25 50
 
Title E17 Art Trail - STEAM theme (Jennifer Simpson) 
Description Laboratory of Tiny Things installation which ran in London for three weeks. Open to the general public. 
Type Of Art Image 
Year Produced 2017 
Impact No known impact 
 
Title The Pathologist - Through the Looking Glass (Jennifer Simpson) 
Description Article showcasing a gallery of beautiful images from all walks of laboratory medicine 
Type Of Art Image 
Year Produced 2017 
Impact No impacts known 
 
Description The key development within high containment science at The Pirbright Institute is that of cutting edge containment facilities that allow handling of viruses with in a safe manner for the user and environment and with minimal interruptions to work. In the three years since the project was initiated, downtime for science has been limited to planned preventative maintenance only in the BBSRC National Virology Centre (Plowright Building) and this has resulted in the production of >100 peer-reviewed publications by our scientists. Our scientists have also delivered over 270 engagement activities, increasing the profile of these studies and providing evidence for their importance within a wider funding context. In year two there was an interruption to use of the contained animal facilities, but this had minimal impact on users through planned rescheduling of engineering maintenance and did not affect strategic programme grant targets. We have worked closely with HSE and remain in full compliance with our SAPO license and other health and safety law. Within the current reporting period we have initiated studies at Containment Level 3 (CL3) on insect vectors, expanding our portfolio of viruses worked on and several new facilities are in the later stages of development (including a new animal isolation unit that will enable CL3 studies in the natural hosts). Meetings with both the Home Office and NC3Rs were recorded within the reporting period. In the first year of the High Containment grant, more than 50 workers received biosecurity training alongside a range of international activities that included membership of BSL4Znet, a network of high containment laboratories and specific partnerships with Ethiopia, Tanzania and Argentina. This ranged from advice on infrastructure planning through to formal processes to maintain a high level of health and safety and biosecurity. Discussions on access and collaboration have been held with a range of partners including University of Surrey, LSHTM, Glasgow University and the Roslin Institute. There was also an on-demand response to ongoing outbreaks of African swine fever virus and bluetongue virus, both of which currently threaten the UK and horizon scanning for foot and mouth disease virus enabled by the high containment infrastructure and our retention of UK reference laboratories that operate at ISO/EC 17025 quality requirements. The Institute website has also been revised to improve the public understanding of how containment facilities work, and a range of outreach exercises have taken place that describe both our science and the role of infrastructure in enabling research. Dedicated videos have also been produced by our communications department with interviews from all the senior members of the CCG group. Infrastructure projects aimed at increasing flexibility in the use of contained animal facilities and in poultry research are continuing.
Exploitation Route Development of high containment infrastructure at Pirbright includes refurbishment of the virus isolation units for livestock which is in response to changing needs at the site. All of our main science programmes rely on both these and the Plowright building for their continuation and are an integral part of our response to virus incursion via reference laboratory functions. Hence, we will continue to learn and improve methods to minimise interruptions to science through advance planning of maintenance and to operate to the highest levels of health and safety and biosecurity. Through this process we will gain knowledge that will be disseminated to other infrastructure laboratories around the world through networking of senior CCG staff and site visits, complemented by outreach activities aimed at key stakeholder groups including the general public. This is a vital aspect of justifying what is a major investment for the UK.
Sectors Agriculture, Food and Drink

 
Description Minimal infrastructure downtime enabled by planned preventative maintenance on the BBSRC National Virology Centre (Plowright Building) and Virus Isolation Units for livestock has enabled both our research to be conducted under expected timescales and our response to potential incursions of foot and mouth disease virus (FMDV), bluetongue virus and African Swine fever virus to be planned with a high degree of reliability. Within the reporting year this has enabled a wide array of scientific outputs and the retention of the world reference laboratory for FMDV. These studies have also been enabled by the adoption of a health and safety and biosecurity approach which is commensurate with risk and which we will continue to modify according to our experience in running the facility.
First Year Of Impact 2017
Sector Agriculture, Food and Drink
Impact Types Societal,Economic,Policy & public services

 
Description BBSRC 18ALERT panel member
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Provision of multi-user equipment to core facilities to enable BBSRC remit science. Part of the remit for this call was to allow shared access from other institutions, widening the impact of BBSRC investment.
 
Description BBSRC ALERT18 panel member (invited)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Panel for ALERT18 multi-user equipment award by BBSRC
 
Description BBSRC Bioimaging Review
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Bioimaging Steering Group
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
Impact Improving access and efficient organization of Bioimaging for researchers at Pirbright
 
Description Contribution to a POSTnote on 'Reducing UK Antibiotic Use in Animals'
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Development and Evaluation of PPR DIVA vaccines
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Peste des petits ruminants (PPR) is a highly contagious disease, severely affects small ruminants in almost 70 countries in Africa, the Middle East and parts of Asia. It causes USD 1.5 to 2 billion in losses each year in regions that are home to over 80% of the world's sheep and goats and to more than 330 million of the world's poorest people, many of whom depend on them for their livelihoods. The estimated current expenditure on PPR vaccination ranges between USD 270 and 380 million. The annual impact of PPR alone may be valued at between USD 1.45 and 2.1 billion per year. Approximately a third of the global financial burden of PPR is borne by Africa, with a further quarter borne by South Asia. This burden will be removed with the successful eradication of PPR. The undiscounted costs for a fifteen-year Global control Strategy of FAO and OIE are between USD 7.6 and 9.1 billion, with the first five years costing between USD 2.5 and 3.1 billion. (http://www.fao.org/3/a-i4460e.pdf). PPR is currently controlled by vaccination using mainly two live attenuated PPRV vaccines (Nigeria 75/1 and Sungri 96). However, the current vaccines and serological tests are unable to enable Differentiation between naturally Infected and Vaccinated Animals (DIVA). This factor precludes meaningful assessment of vaccine coverage and epidemiological surveillance based on serology, in turn reducing the efficiency of control programmes. Therefore, it is almost impossible to assess the quality and efficacy of existing PPR vaccines without knowing whether positive animals are vaccinated or naturally infected. Unlike rinderpest, where cattle and buffalo were primary hosts, in PPR, new crops (about 30-40%) of lambs and kids are produced every year and are the most susceptible population to bring back new PPR outbreaks6&7. Therefore, it is likely that the cycle of vaccinations and PPR outbreaks will continue until and unless we reach the stage of 80-90% herd immunity. Therefore, development of a marker vaccine and associated DIVA diagnostics will enable the assessment of vaccine efficacy which is essential for any successful vaccination campaign. https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-peste-des-petits-ruminant The availability of a recombinant PPRV vaccine with a proven functionality is a prerequisite for the development of novel vaccines that may enable the development of DIVA tools for PPRV diagnostics. In the DBT-BBSRC FADH BB/L004801/1 grant we have rescued Sungri 96 and Nigeria 75/1 vaccine strains. Both the vaccine strains were rescued from respective synthetic c-DNA clones with mutations in the variable part of C terminus of the nucleocapsid (N) gene similar to Dolphin Morbillivirus (DMV) to enable negative marker DIVA vaccines. These two DIVA vaccines along with parental vaccines have been recently tested in a pilot studies in goats. Both the DIVA and parent vaccines provided safety, stability and protection for vaccinated goats whereas the control animals were clinically infected. Patent applications have been made to protect these DIVA vaccines. Agreements are being done with vaccine industries for the licensing and commercialisation.
URL https://www.pirbright.ac.uk/press-releases/2018/09/pirbright-collaboration-provides-tools-peste-des-...
 
Description Drafted resolution that was endorsed by the World Assembly of Delegates (for the World Oganisation of Animal Health - OIE)
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact This policy document relates to one of the FMDV serotypes (called serotype C) which has disappeared for >10 years from the surveillance activities of the global OIE/FAO FMD Reference Laboratories (led by the Pirbright Institute). These laboratories now consider that the production of FMDV serotype C vaccines and their use in vaccine challenge experiments represent a risk of virus escape. Based on this evidence and concerns, this resolution urges that OIE Member Countries and vaccine manufacturers to stop the use of FMDV serotype C in vaccine challenge experiments and to consider halting the production of FMDV serotype C vaccines and inclusion in multivalent FMD vaccines except for holding in vaccine banks.
URL http://www.oie.int/fileadmin/Home/eng/About_us/docs/pdf/Session/2017/A_RESO_2017_Public.pdf
 
Description EFSA working group on Rift Valley fever
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Analysis of data on Rift Valley fever; assessment of risk of introduction to European Union; advice to European Commission on control measures
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact The models developed to describe the spread of lumpy skin disease virus (LSDV) within and between farms have been used to inform disease control policy following incursion of LSDV to south-eastern Europe. Specifically, the models were used to assess the impact of vaccination on disease spread. They were also used to investigate the duration of a vaccination campaign to prevent re-emergence of LSDV and to help design surveillance programmes to detect the re-emergence of the virus or its re-introduction from neighbouring countries. The results have been communicated to the European Commission and to affected countries via the European Food Safety Authority.
URL https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5452
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Report to the European Commission on the spread and control of lumpy skin disease in the Balkans
URL http://www.efsa.europa.eu/en/efsajournal/pub/5176
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Collation of data on lumpy skin disease outbreaks in Europe and neighbouring regions; provision of advice to European Commission and to affected countries on control and surveillance
URL https://www.efsa.europa.eu/en/efsajournal/pub/6010
 
Description I provided images of the gross pathology of lumpy skin disease (LSD) to Defra and to the Swiss veterinary authorities for the purpose of educating veterinarians and promoting rapid diagnosis of LSD should it emerge in Switzerland or the UK
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Inter-institute imaging network
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Invited member of RCaH Science Advisory Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact The Research Complex at Harwell is a UKRI funded building with the remit of enabling researchers across many disciplines to take advantage of the national facilities on the Harwell campus. RCaH is going through significant change at the moment and the advisory board has been asked to contribute to defining its future direction.
 
Description Invited participant, UK SAGE exercise on a zoonotic outbreak
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Participation in a simulated outbreak of Rift Valley fever to UK to identify gaps in response, including detection, implementation of control measures (for livestock and humans) and communication.
 
Description Livestock Viral Diseases Pathology Slide Set. A set of histology slides of tissues from livestock affected by notifiable viral diseases, provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland.
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Lumpy Skin Disease Control Strategy for Great Britain
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Member of RMS EM Section committee
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact This committee informs the RMS on which areas to invest funds in regarding training, conferences, outreach events. RMS members are international.
 
Description POSTnote Report on Climate and vector-diseases in humans in the UK
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description PPR DIVA Vaccine development . FAO/OIE in the meeting proceedings in December, 2018 recorded the future use of DIVA vaccine in the ongoing PPR eradication programme. This will be useful at least at the end phase of eradication to differentiate between vaccination and infection.As such few industries have contacted us to have the DIVA vaccine strains for commercialisation. Also some of the endemic countries are keen to have the strain for testing the DIVA vaccines in endemic settings.
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description PPR Global Research and Expertise Network (PPR GREN) membership (OIE/FAO)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Publication policy document for core facilities - EM-UK
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact I am a founder member of the network created for electron microscopists within UK, EM-UK. The annual meeting is highly productive, and training and managing core facilities is regularly discussed. Recognition of these facilities is essential for their continued existence so we produced a generic document hosted on the RMS website which can be adopted by any core facility in any institution, and describes the publication policy which users had to adhere to. This has already raised the profile of core facilities around the country and is a successful outcome from the EM-UK meetings.
 
Description Royal Microscopical Society Microscopy Training Focussed Interest Group
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Royal Microscopical Society Training Focussed Interest Group
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact A review of the microscopy training courses available globally has been undertaken. We are in the process of collating and preparing a gap analysis. This will be used to guide RMS policy on training provided in the UK, both UK and international delegates.
 
Description Scientific Advisory Group for Emergencies Exercise (Royal Society: 11/06/19): Examined simulated emergence of arbovirus in the UK with main decision making bodies and personnel.
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description University of Surrey MSc Vet microbiology - teaching (Jennifer Simpson)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Two days of teaching practical microscopy, a useful cross disciplinary skill for many researchers
 
Description A One Health approach to pan-valent morbillivirus vaccines
Amount £773,237 (GBP)
Funding ID BB/R019843/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 03/2021
 
Description Active and passive Immunity induced by aerosols
Amount £100,000 (GBP)
Funding ID BB/R506448/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 08/2021
 
Description BBSRC IAA'
Amount £30,000 (GBP)
Funding ID BB/S506680/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 04/2020
 
Description BBSRC Industrial CASE (iCASE) studentship programme Oxford Interdisciplinary Bioscience Doctoral Training Partnership
Amount £80,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 09/2023
 
Description BBSRC Newton Fund Swine and Poultry Research Initiative
Amount £865,623 (GBP)
Funding ID BB/R01275X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 06/2021
 
Description BBSRC responsive mode funding
Amount £356,484 (GBP)
Funding ID BB/T005173/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2020 
End 12/2021
 
Description BBSRC responsive mode grant
Amount £367,000 (GBP)
Funding ID BB/P006841/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 03/2019
 
Description BBSRC-funded Oxford Doctoral Training Partnership in vivo skills award
Amount £15,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2020 
End 06/2021
 
Description Biotechnology and Biological Sciences Research Council (BBSRC) and University of Oxford joint Doctoral Training Project
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description Broad and effective protection against influenza achieved by viral vectored vaccines
Amount £1,607,691 (GBP)
Funding ID MR/S037160/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2019 
End 04/2022
 
Description Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence
Amount £200,000 (GBP)
Funding ID LKCS-2019- 665 
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 10/2022
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti
Amount £1,209,348 (GBP)
Funding ID BB/S001964/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2021
 
Description DARPA PREEMPT
Amount $2,700,000 (USD)
Organisation Defense Advanced Research Projects Agency (DARPA) 
Sector Public
Country United States
Start 10/2018 
End 03/2022
 
Description Development of novel universal influenza vaccines
Amount £120,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 10/2020
 
Description Evaluation of CD4+ T-cell responses to vaccination with next generation FMD vaccines using Tetramer-guided epitope mapping of foot-and-mouth disease virus capsid
Amount £18,000 (GBP)
Funding ID IEVI808400 
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 07/2019
 
Description FLI- TPI joint PhD studentships Avian influenza immunology markers.
Amount £100,000 (GBP)
Organisation Friedrich Loeffler Institute 
Sector Academic/University
Country Germany
Start 07/2018 
End 06/2022
 
Description Genomia Project Grant
Amount £174,052 (GBP)
Organisation Genomia fund 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2019 
End 01/2020
 
Description H2020 work programme topic 9 Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy, work topic SFS-10-2017 Research and approaches for emerging diseases in plants and terrestrial livestock
Amount € 5,986,250 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 05/2018 
End 04/2023
 
Description International Workshops
Amount £10,000 (GBP)
Funding ID BB/R021198/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 05/2019
 
Description Market research and technical feasibility of a bivalent porcine reproductive and respiratory syndrome / Nipah virus vaccine
Amount £10,880 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 07/2019 
End 03/2020
 
Description Newton Fund: The Researcher Links Travel Grants from British Council
Amount £35,400 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 05/2017
 
Description Newton Fund: UK-China-Philippines-Thailand Swine and Poultry Research Initiative
Amount £841,995 (GBP)
Funding ID BB/R012679/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2020
 
Description Novel Mucosal T cells in immunity to swine influenza
Amount £120,000 (GBP)
Funding ID Novel Mucosal T cells in immunity to swine influenza 
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 10/2020
 
Description OIE Twinning: Development of capacity for independent assessment of FMDV vaccines in Africa
Amount $1,466,186 (USD)
Organisation World Organisation for Animal Health 
Sector Public
Country France
Start 04/2019 
End 03/2021
 
Description Oxford DTP - Diamond Light Source/Harwell
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Passive and active immunity in the porcine influenza model
Amount £120,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 01/2021
 
Description Pirbright Institute Flexible Talent Mobility Account
Amount £180,000 (GBP)
Funding ID BB/S507945/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 03/2021
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 09/2023
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Quadrivalent foot-and-mouth disease virus vaccine technology
Amount $1,474,103 (USD)
Funding ID INV-003628 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 08/2019 
End 02/2022
 
Description Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field.
Amount £400,000 (GBP)
Funding ID BB/S013792/1 
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 01/2021
 
Description SFS-10-2017 - Research and approaches for emerging diseases and pests in plants and terrestrial livestock: Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND)
Amount € 5,986,250 (EUR)
Funding ID 773701 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 06/2018 
End 05/2023
 
Description The Global Challenges Research Fund
Amount £640,473 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2024
 
Description The Pirbright Institute Flexible Talent Mobility Account Innovation Fellowship
Amount £19,636 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2020 
End 10/2020
 
Description The Pirbright Livestock Antibody Hub
Amount $5,530,900 (USD)
Funding ID INV-003007 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2019 
End 09/2024
 
Description The Pirbright Livestock Antibody Hub
Amount $5,500,000 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2019 
End 11/2024
 
Description The Pirbright Livestock Antibody Hub
Amount NU$ 5,500,000 (UYU)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2019 
End 08/2024
 
Description The genetic and functional analysis of variation in innate immune genes associated with restriction of influenza virus for chicken lines
Amount £422,383 (GBP)
Organisation Aviagen Group 
Sector Private
Country United States
Start 01/2020 
End 03/2021
 
Description Use of FMDV sequence data to trace outbreaks and monitor disease incursion risks to the UK
Amount £1,326,558 (GBP)
Funding ID SE2944 
Organisation Department For Environment, Food And Rural Affairs (DEFRA) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2022
 
Description Workpackage within a Horzion 20:20 grant
Amount € 6,000,000 (EUR)
Funding ID EU project 727393 Horizon 20:20 PALE-Blue 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 06/2017 
End 11/2020
 
Description [YY-EEID US-UK XXXX] Evaluating how immunosuppression influences influenza A virus transmission and evolution in wild and domestic birds
Amount £606,360 (GBP)
Funding ID BB/T008806/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2023
 
Description iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 09/2023
 
Title A male-specific cell line from a mosquito Anopheles gambiae 
Description A new male-specific cell line from a mosquito Anopheles gambiae has been isolated from sexed neonate larvae. To our knowledge this is the only cell line derived exclusively from male mosquitoes. 
Type Of Material Cell line 
Year Produced 2019 
Provided To Others? No  
Impact The cell line will greatly facilitate studies on components of the sex determination pathway and of dosage compensation machinery in mosquitoes. There are only several cell lines derived from Anopheles gambiae available and these are female-like. Over-expression of genes involved in male sex determination or dosage compensation is detrimental to female cells, hence use of male-derived cells is necessary for such studies. The cell line will become available upon acceptance of a manuscript describing characterization of that cell line. 
 
Title Correlative Light and Electron Microscopy (CLEM) on IBDV-infected cells 
Description Jenny Simpson and Pippa Hawes have developed the technique of Correlative Light and Electron Microscopy (CLEM). This technique has been used to visualise Virus Factories of IBDV. 
Type Of Material Technology assay or reagent 
Year Produced 2019 
Provided To Others? No  
Impact The Virus Factories (VFs) of IBDV were thought to be paracrystalline arrays of virions in the cytoplasm. However, combining our GFP11-tagged IBDV with CLEM technology revealed that the VFs are actually proteinaceous accumulations in the cytoplasm. This has opened up a new avenue of research in terms of the ultrastructure, formation and function of the VFs. 
 
Title Detection of HA antigens of avian influenza viruses 
Description Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. 
 
Title Development of CLEM techniques for RSV 
Description We have developed the technical expertise to perform correlative light electron microscopy on respiratory syncytial virus infected cells. This allows us to directly compare immunofluorescent images with transmission EM of the same cell. 
Type Of Material Technology assay or reagent 
Year Produced 2019 
Provided To Others? No  
Impact We have recently submitted a paper and grant building on this expertise, as well as forging new collaborations with Diamond light source. 
 
Title Development of tetramers to study immune responses in pigs 
Description The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume. It is also an important vector in the birds to human infection cycle. A major drawback of the current pig model is the inability to analyze antigen-specific CD8+ T-cell responses, which are critical to respiratory immunity. We addressed this knowledge gap using an established in-bred pig model with a high degree of genetic identity between individuals, including the MHC (Swine Leukocyte Antigen (SLA)) locus. We developed a toolset that included long-term in vitro pig T-cell culture and cloning and identification of novel immunodominant influenza-derived T-cell epitopes. We also generated structures of the two SLA class I molecules found in these animals presenting the immunodominant epitopes. These structures allowed definition of the primary anchor points for epitopes in the SLA binding groove and established SLA binding motifs that were used to successfully predict other influenza-derived peptide sequences capable of stimulating T-cells. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Peptide-SLA tetramers were constructed and used to track influenza-specific T-cells ex vivo in blood, the lungs and draining lymph nodes. Aerosol immunization with attenuated single cycle influenza viruses (S-FLU) induced large numbers of CD8+ T-cells specific for conserved NP peptides in the respiratory tract. Collectively, these data substantially increase the utility of pigs as an effective model for studying protective local cellular immunity against respiratory pathogens. 
 
Title Ex vivo skin model 
Description An in vitro model of bovine skin has been developed, designed to allow feeding of dipteran species. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2019 
Provided To Others? No  
Impact This has already reduced the number of procedures carried out on cattle in our studies by providing an alternative to insects feeding on cattle. 
 
Title Generation of monocyte-derived dendritic cells and analyses of their infection by foot-and-mouth disease virus 
Description CD14+ cells were selected. Day 4 monocyte-derived dendritic cells (moDC) were generated by positive selection using CD14 magnetic beads and LS columns, followed by differentiation by culturing in the presence of IL-4 and GM-CSF. Both non-cell culture adapted and cell culture adapted FMDV were used in this study. Immuno-fluorescence microscopy (IFM) was used to investigate internalisation of FMDV and immune complexed (IC) FMDV at 1-6 hours post infection (hpi) and also to investigate the uptake pathways utilised by non-cell culture and cell culture adapted FMDV in the presence of different pharmacological inhibitors. Western blot, IFM and quantitative RT-PCR was used to analyse viral replication at 0-6, 8, 16 and 24 hpi. Plaque assays were used to investigate the yields of live virus produced in moDC at 0, 4, 8 and 24 hpi. Flow cytometry was used to investigate the changes in IL-12 and IL-10 secretion following FMDV infection at 2, 4 and 6 hpi. MxCAT ELISA was used to investigate the secretion of IFN at different times post infection. 
Type Of Material Cell line 
Year Produced 2019 
Provided To Others? No  
Impact These methods were used to generate MODC and characterise their interaction with FMDV. They are currently being incorporated into a manuscript for peer review and provide a workflow to analyse FMDV infections of other dendritic cell types. 
 
Title Method to evenly load flowcells with multiple samples 
Description Pirbright has an Illumina NextSeq sequencing machine installed in containment. Given the large amount of sequencing reads produced by each run, multiple samples are usually multiplexed on the same flowcell. However, determining the correct concentrations needed to obtain the same amount of reads for each sample is a hard problem, and usually requires a number of expensive and material-consuming kits to be run prior to sequencing. We have developed a method that allows samples to be evenly multiplexed based only on Bioanalyzer data (we routinely run Bioanalyser on the samples anyway as a form of quality control). The method works well, and reliably across a wide range of sample concentrations and sequenced organisms. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact The method greatly increased the quality of our output, and drastically simplified our workflow by eliminating the external quantification steps that were previously required. 
 
Title Microbiopsy method 
Description We have optimised a technique for cutaneous skin biopsy of cattle. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2019 
Provided To Others? No  
Impact The microbiopsy technique is less invasive and less painful than the traditional biopsy technique 
 
Title NGS for PPR virus whole genome sequencing 
Description We have finalised a protocol to sequence the whole genome of PPR virus 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The method has been described and shard with project partners and a draft has been written for publishing the methods 
 
Title method for identification of lung Tissue resident memory cells in pigs 
Description Recent overwhelming evidence indicates the importance of local tissue-resident memory T cells (TRM) in protective immunity. Most work on TRM has been performed in mice and the TRM defined as inaccessible to intravenously administered anti-T cell antibody. However there are very few data on TRM in large animals. For the first time we have defined TRM in the pig influenza model. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact The identification of TRM and their robust protective capacity in site-specific infection has provided a new paradigm by which to assess T cell-mediated responses and an important new target for vaccine design. Since swine are an economically important species, are used as a large animal model for human infection and play a key role in the emergence of novel and potentially zoonotic influenza viruses, the identification of TRM in pigs will allow us to study their role in immunity to swine influenza.and how best to induce them by immunisation. 
 
Description Aerosol delivery of vaccines and therapeutics 
Organisation Aerogen
Country Ireland 
Sector Private 
PI Contribution Developed the pig influenza model which is a natural host pathogen system
Collaborator Contribution Provided expertise and equipment for aerosol delivery
Impact Successfully delivered vaccines by aerosol
Start Year 2015
 
Description Anihwa Call 1 
Organisation Friedrich Loeffler Institute
Country Germany 
Sector Academic/University 
PI Contribution 1. Conducted challenge experiments in goats to study pathogenicity. 2. Developed NGS technology to sequence PPR whole genome.
Collaborator Contribution FLI has conducted transmission study between different species ( Goats, pig, camel). For the first time they showed that pigs are clinically infected by PPR virus.
Impact Joint Publications
Start Year 2013
 
Description Assembly of CHIKV in host cells/JEOL TEM training 
Organisation National Cheng Kung University
Country Taiwan, Province of China 
Sector Academic/University 
PI Contribution Visit to Tainan in May 2017, provided training in cellular imaging of virally infected cells. Gave a seminar entitled Bioimaging at The Pirbright Institute. Hosted two visitors for two weeks in Bioimaging at Pirbright, provided training in EM sample preparation and data interpretation.
Collaborator Contribution Professor Shang-Rung Wu hosted me for one week in Taiwan. During the visit to Pirbright, the Taiwanese researchers provided training on JEOL 2100F TEM to Pirbright researchers. Professor Wu provided prepared samples for imaging at a later date.
Impact No outputs yet
Start Year 2017
 
Description Assembly of DNA virus (tegumentation of HSV) 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Use of advanced microscopes to investigate tegumentation of HSV
Collaborator Contribution Molecular biology skills and reagents for investigating tegumentation of HSV
Impact Joint Pirbright-Surrey PhD studentship
Start Year 2018
 
Description BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production.
Collaborator Contribution The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses.
Impact This project started in January 2020.
Start Year 2020
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of California, Davis
Department UC Davis College of Biological Sciences
Country United States 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description Bioimaging collaboration with Dr. Daniel Clare, Dr. James Gilchrist, Dr. Pippa Hawes - cryo-electron tomography Diamond Light Source 
Organisation Diamond Light Source
Country United Kingdom 
Sector Private 
PI Contribution Development of preliminary data on inclusion body structure to support higher resolution approaches.
Collaborator Contribution Discussion of project and experimental design, technological approaches and limitations.
Impact No outputs to date. Multi-disciplinary team of virologists and structural biologists
Start Year 2020
 
Description Chicken Microbiome - Robert La Ragione - University of Surrey 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing sequencing data of gut microbiome from chickens infected with avian influenza viruses.
Collaborator Contribution Sharing expertise in the analysis of microbiome data
Impact Joint manuscripts and funding opportunities are being explored
Start Year 2019
 
Description Collaboration on replication of mumps virus in cells 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes
Collaborator Contribution Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM.
Impact No outcomes yet
Start Year 2018
 
Description Collaboration with Bauchi State Veterinary Services, Nigeria 
Organisation Bauchi State University
Country Nigeria 
Sector Academic/University 
PI Contribution We have provided expertise on sheeppox, goatpox and lumpy skin disease virus diagnosis and epidemiology
Collaborator Contribution Our collaborators in Bauchi State have provided virus samples and epidemiological data
Impact Preliminary data was used to support successful funding via a BBSRC Impact Accelerator Award, and a Pathways to Impact project in BBSRC project BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines"
Start Year 2016
 
Description Collaboration with State Central Veterinary Laboratory, Mongolia 
Organisation State Central Veterinary Laboratory
Country Mongolia 
Sector Public 
PI Contribution We provided tools, techniques and expertise on sheeppox and goatpox
Collaborator Contribution Our colleagues provided data and field samples
Impact A workshop was held in Pirbright in March 2017, and a return workshop in Ulaanbaatar in July 2017. Preliminary data supported successful grant applications for an Impact Accelerator Award, and a Pathways to Impact project in BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines".
Start Year 2016
 
Description Collaboration with University of Copenhagen CFIM on cell biology of virus-host interactions 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Intellectual input into virus projects which come in to the microscopy core facility at the University. Limited practical work and training given to researchers there. Includes lecturing/organisation of MSc and PhD courses at Copenhagen. PH awarded Visiting Professorship.
Collaborator Contribution Research projects are presented to the core facility, I advise on the best route for achieving the data required and those researchers complete preliminary data following my advice. Collaborators are then able to produce the best possible samples for further advanced microscopy as necessary.
Impact No tangible outcomes yet as we are in early stages. This is multi-disciplinary as projects can come from several University departments (medical, pathology, cell biology, veterinary, food), and other Universities in Denmark (DTU). University awarded Visiting Professorship
Start Year 2018
 
Description Collaborative PhD student project on virus-bacteria-host-vector interaction 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a collaborative PhD studentship funded by The Pirbright Institute between Pirbright and the Roslin Institute. The student is investigating how bacteria or bacterial compounds will effect bluetongue virus replication in mammalian host cells with a specific emphasis on skin derived migratory cells. While mainly based at Pirbright the student will visit the Roslin Institute and spend some time in the lab of Prof. Jane Hope.
Collaborator Contribution The student will carry out the main laboratory work at Pirbright including infection studies of ruminant primary host target cells in the presence/ absence of bacterial compounds. There will be regular meetings between the students and supervisors at Pirbright and at Roslin (at least monthly by skype) and the student will visit the Roslin group for specific work aspects such as flow cytometry of skin derived pseudo-afferent lymph cells. Roslin will also make cattle pseudo-afferent lymph cells available to the student and Pirbright for ex vivo BTV infection studies.
Impact bacteriology, virology, immunology, virus-host interaction
Start Year 2019
 
Description Collaborative doctoral project on BTV variant selection by the Culicoides insect vector 
Organisation Friedrich Loeffler Institute
Department Institute of Infectology
Country Germany 
Sector Academic/University 
PI Contribution This is a shared doctoral project funded by the German partner where the student will spend one year in our lab from May 2019-2020. The student has so far carried out her first year at FLI in Germany and came for a 2 weeks visit to our lab where we provided training on Culicoides biting midge biology, virus titration and handling, virus infection of insects and molecular diagnostics. We also have monthly Skype meetings to discuss data and advice on research plans
Collaborator Contribution The doctoral candidate will spend at least 2 years practical work within the labs at Germany, the entire project (student salary, consumables, travel) is funded by the German partner. We will share data obtained at either side and publish results together accordingly
Impact This partnership is still ongoing. Each partner contributes their unique expertise (Virology, insect biology, next-generation sequencing and bioinformatics), the student will start placement at The Pirbright Institute for 1 year in May 2019
Start Year 2017
 
Description Collaborative project between The Pirbright Institute, UK and Kasetsart University, Thailand 
Organisation Kasetsart University
Country Thailand 
Sector Academic/University 
PI Contribution Hosting student from Kasetsart university for 6 months and providing expertise in recombinant FMDV technology and high containment SAPO4 facilities
Collaborator Contribution Financial support for student and co-authorship on future publication.
Impact The project involves the use of reverse genetics to generate recombinant foot-and-mouth disease viruses with improved cell culture adaptation properties.
Start Year 2019
 
Description Collaborative project between The Pirbright Institute, UK and Miyazaki University, Japan 
Organisation University of Miyazaki
Country Japan 
Sector Academic/University 
PI Contribution Provision of expertise in foot-and-mouth virus research; use of high containment facilities to perform experiments
Collaborator Contribution Expertise in tetramer production and analysis
Impact The protection afforded by most foot-and-mouth disease (FMD) vaccines depends to a large extent on humoral immunity, dictating the need to characterise the underlying mechanisms that mediate antibody production. To address this, we have developed novel major histocompatibility complex (pMHC) class II tetramers to identify antigen specific CD4+ T-cells that are present following vaccination against FMD. To date, we have used a MHC II tetramer (MHC serotype: A18) and peripheral blood mononuclear cells (PBMCs) from MHC-matched cattle vaccinated against FMD (O serotype). Importantly, we have identified CD4+ T-cells that recognise 15 epitopes (identified from 137 peptides) in the FMDV structural proteins; one in VP1, five in VP2, six in VP3 and three in VP4. This work will further our understanding of the repertoire of capsid epitopes recognised by the host's immune response following FMD vaccination and facilitate the identification of new correlates of protection.
Start Year 2017
 
Description Collaborative studentship PPRV 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Practical laboratory work and in vivo animal studies carried out
Collaborator Contribution Intellectual input in scientific remit of studentship, training of student, use of facilities and lab
Impact DOI: 10.1128/JVI.01471-18 Thesis: The immune response to live, attenuated peste des petits ruminants virus vaccines
Start Year 2014
 
Description Collaborative studentship between The Pirbright Institute and Friedrich Loeffler Institute 
Organisation Friedrich Loeffler Institute
Country Germany 
Sector Academic/University 
PI Contribution The 3.5 year studentship is based at The Pirbright Institute with a 6-12 month period of research at FLI.
Collaborator Contribution FLI will provide access to their extensive collection of mammalian cell lines.
Impact Title: Functional characterisation of foot-and-mouth virus replication in mammalian cell lines. The project will investigate FMDV infection in different wild type and gene-edited mammalian cell lines, and will determine the effects that host proteins such as type1 IFN have on virus replication.
Start Year 2018
 
Description Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution I develop a research project proposal in which we are investigating how evolutionary changes in the H9N2 avian influenza virus modulate virus fitness and virulence in chickens. This PhD studentship project was funded by Commonwealth scholarship commission for 3 years.
Collaborator Contribution The collaborating Partner Dr Nicola Lewis at Royal Veterinary College is a co-supervisor of the PhD student Thusitha Karunarathna. she provide necessary guidance to achieve prescribed objectives of this project.
Impact The project is at its initial stage.
Start Year 2019
 
Description DSTL collaboration with Steve Lever and Diane Williamson 
Organisation Defence Science & Technology Laboratory (DSTL)
Country United Kingdom 
Sector Public 
PI Contribution Discussion of experimental design for Nipah virus animal model establishment at DSTL
Collaborator Contribution Discussion of experimental design for Nipah virus animal model establishment at DSTL
Impact No outputs to date
Start Year 2019
 
Description DTU 
Organisation Technical University of Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Joint PhD studentship
Collaborator Contribution Joint PhD studentship
Impact Joint PhD studentship in progress
Start Year 2016
 
Description Development of tetramers in the Babraham pig model 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed the aerosol delivery method of vaccine and provided material (spleen, BAL and blood) from inbred animals (Babraham pigs) following immunisation with the candidate universal vaccine, S-FLU.
Collaborator Contribution Developed porcine influenza specific class I tetramers and provided the epitope map of Babrahams S-Flu responses to NP, M1, M2, PB1 and PB2 that could be presented by SLA-1 or SLA-2 Grew pig T cell clones for the first time in 30 years.
Impact Multidisciplinary - immunology, virology, protein chemistry. Paper not yet published
Start Year 2014
 
Description Dr Carol Cardona, University of Minnesota- avian influenza virus challenge of IBDV or mock-infected chickens 
Organisation University of Minnesota
Country United States 
Sector Academic/University 
PI Contribution We will challenge birds that have been exposed to IBDV, or mock exposed, with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens.
Collaborator Contribution Dr Cardona's group will challenge birds that have been exposed to IBDV, or mock exposed, with low pathogenic avian influenza (LPAI) strains to determine how IBDV-mediated immunosuppression impacts upon LPAI infection in chickens.
Impact we have been successful in obtaining funding (Grant Ref: BB/T008806/1)
Start Year 2019
 
Description Dr Holly Shelton, The Pirbright Institute- avian influenza virus challenge of IBDV or mock-infected chickens 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We will expose birds to IBDV, compared to mock controls
Collaborator Contribution Holly will train my group in conducting studies with avian influenza viruses and, together, we will challenge birds with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens.
Impact we have been successful in obtaining funding (Grant Ref: BB/T008806/1)
Start Year 2019
 
Description Dundee 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-INvestigator on BBSRC sLoLa award
Collaborator Contribution Co-INvestigator on BBSRC sLoLa award
Impact BBSRC sLoLa award ongoing
Start Year 2012
 
Description Edinburgh 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-INvestigator on BBSRC sLoLa award
Collaborator Contribution Co-INvestigator on BBSRC sLoLa award
Impact BBSRC sLoLa award ongoing
Start Year 2012
 
Description Efficacy of a candidate universal influenza vaccine, S-FLU. 
Organisation University of Oxford
Department Radcliffe Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Tested the immunogenicity and efficacy of a candidate universal influenza vaccine, S-FLU, in pigs. For the first time we demonstrated that S-FLU when administered by aerosol can reduce viral load in nasal swabs and lung in pigs after influenza virus challenge. We have shown that the most efficient way to administer this vaccine is by aerosol.
Collaborator Contribution Professor Alain Townsend has developed the S-FLU vaccine.
Impact The most efficient way to induce immune response in the lung is after aerosol delivery of LAIV vaccines in pigs. The most efficient way to induce cross-protective immunity is by aerosol delivery of S-FLU to the lungs of pigs
Start Year 2014
 
Description Evaluation of a PRRSV-vectored Nipah virus vaccine 
Organisation National Center for Genetic Engineering and Biotechnology (BIOTEC)
Country Thailand 
Sector Public 
PI Contribution Expertise in porcine immunology/vaccinology, inc. PRRSV and Nipah
Collaborator Contribution Expertise in PRRSV reverse genetics
Impact None as yet
Start Year 2019
 
Description Genetic analysis orbiviruses 
Organisation University of Surrey
Department Faculty of Health and Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Virus sequences provided for analysis. Meeting and discussion for analysis by virologist employed on this project and biomathematican at the University of Surrey
Collaborator Contribution Analysis of data, training of the virologist and computational and mathematical methodology, discussion about analysis strategies
Impact The collaboration is multi-disciplinary - between mathematical modelling and virology. Data analysis is still ongoing but is envisaged as preliminary data for future funding applications
Start Year 2017
 
Description High containment microscopy with Thermo Fisher 
Organisation Thermo Fisher Scientific
Country United States 
Sector Private 
PI Contribution Provide advice on decontamination protocols
Collaborator Contribution Development/optimisation of microscope decontamination procedures
Impact No outputs yet, very early stages of collaboration
Start Year 2019
 
Description Imperial 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint supervision of PhD student
Collaborator Contribution Joint supervision of PhD student
Impact One successful completed PhD student. Papers published or in preparation. Another PhD student in progress.
Start Year 2010
 
Description Interferon stimulated genes 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Hosted meetings and carried out preliminary experiments
Collaborator Contribution Contributed reagents and expertise
Impact Preliminary data was used to support an MSc project. This has since led to a publication and a PhD project.
Start Year 2016
 
Description Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses 
Organisation Royal Veterinary College (RVC)
Department Veterinary Basic Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy.
Collaborator Contribution provided intellectual input for achieving prescribed objectives of this work.
Impact Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019.
Start Year 2019
 
Description JN - Preparation of capped mesoporpus silica nanoparticles 
Organisation Polytechnic University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments
Collaborator Contribution Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments.
Impact Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples
Start Year 2016
 
Description LMB 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration
Collaborator Contribution Collaboration
Impact Collaborative research
Start Year 2016
 
Description Leeds FBS 
Organisation University of Leeds
Department Leeds Institute of Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution Research and student supervision
Impact Research
Start Year 2009
 
Description Livestock Viral Diseases Pathology Slide Set 
Organisation Scotland's Rural College
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Pip Beard (The Pirbright Institute) and Dr Sandra Scholes (Scotland's Rural College) designed a set of histology slides of tissues from livestock affected by notifiable viral diseases. The Livestock Viral Diseases Pathology Slide Set contains examples of lumpy skin disease, African swine fever, bluetongue, rift valley fever, and peste des petits ruminant. The slide set has been provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland. This activity was included in the Pathways to Impact of BB/R002606.
Collaborator Contribution Dr Pip Beard (The Pirbright Institute) and Dr Sandra Scholes (Scotland's Rural College) designed a set of histology slides of tissues from livestock affected by notifiable viral diseases. The Livestock Viral Diseases Pathology Slide Set contains examples of lumpy skin disease, African swine fever, bluetongue, rift valley fever, and peste des petits ruminant. The slide set has been provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland.
Impact None yet
Start Year 2018
 
Description Mapping ligand binding domain on African swine fever virus CD2v protein 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Testing of mutant versions of CD2v extracellular domain for ability to bind to red blood cells
Collaborator Contribution Produced predicted model of CD2v extracellular domain and selected mutations to be made
Impact Preliminary results for publication and future funding application
Start Year 2018
 
Description Merial 
Organisation Sanofi
Department Merial Plc
Country Global 
Sector Private 
PI Contribution BBSRC Link award
Collaborator Contribution BBSRC Link award
Impact BBSRC Link award in progress
Start Year 2016
 
Description Miles Carroll PHE collaboration on pseudotyping 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Provision of reagents to perform pseudotyping of Ebola G protein
Collaborator Contribution Discussion of preliminary data
Impact None to date, publications in preparation.
Start Year 2019
 
Description Mosquito Interest Group 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques.
Collaborator Contribution Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques.
Impact Exchange of practical techniques, for instance in tracking oviposition of individual mosquitoes. Brainstorming for projects and papers, resulting in a GCRF VBD network proposal (which passed the first review but was not funded in the second) and an informal collaboration (which was intended for submission to UK-Thai call in 2017 but Thai partner was not eligible). Exchanges of colony strains of insects planned this month.
Start Year 2016
 
Description Mucosally Associated Invariant T cells (MAIT) in pig influenza model 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Identified MAIT cells in pig Influenza model. Provide samples from infected and immunised protected animals
Collaborator Contribution Provide expertise in characterising MAIT: development of tetramer; Zell scanner technology allowing high resolution studies of cell phenotype and functions
Impact Joint PhD studentship with Paul Klenerman, University of Oxford
Start Year 2016
 
Description Novel PRRS and swine influenza vaccines 
Organisation National Center for Genetic Engineering and Biotechnology (BIOTEC)
Country Thailand 
Sector Public 
PI Contribution Expertise in PRRS immunology and vaccine evaluation.
Collaborator Contribution Novel vaccine strains and SE Asian field strains
Impact Collaborative grant proposal funded under the BBSRC Newton Fund UK-China-Philippines-Thailand Swine and Poultry Research Initiative
Start Year 2017
 
Description Oxford - Strubi 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on virus structural biology and joint PhD studentship
Collaborator Contribution Collaboration on virus structural biology and joint PhD studentship
Impact Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging
Start Year 2008
 
Description PRRS and Influenza co-nfection studies 
Organisation Government of Thailand
Department National Science and Technology Development Agency (NSTDA)
Country Thailand 
Sector Public 
PI Contribution The Pirbright team of 4 scientists with expertise in immunology and animal care visited Thailand in July 2018 to train Thai colleagues to perform animal experiments (Chiang Mai) and analyse immune responses by ELISPOT and Flow cytometry (Bangkok). This provided Thailand with trained personnel and expertise in testing vaccines in pigs. As a result of the joint work, the Chiang Mai animal facility is currently being renovated. Development of such an animal facility will promote the production and testing of more vaccines by Thai scientists.
Collaborator Contribution Our Thai colleagues provided us with local Thai PRRS and Influenza virus strains which we use in our co-infection studies.
Impact None yet
Start Year 2018
 
Description Pathology of BTV in T cell depleted sheep 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Carrying out animal studies, taking samples for histopathology and sending material
Collaborator Contribution Certified pathologist will attend selected necropsies, sample processing and pathological analysis
Impact Protocols and sample sending established - first clinical trial to start in March 2018
Start Year 2017
 
Description Pathology of bovine skin post Culicoides midge blood-feeding 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Collection of skin samples from cattle responding with local inflammation to Culicoides biting midges blood feeding, sending of materials
Collaborator Contribution Processing of samples, histopathological analysis, sharing of results
Impact Further identification of cellular and histological local changes in ruminant skin to Culicoides blood-feeing which will inform pathogenesis of co-transmitted arboviruses such as BTV
Start Year 2017
 
Description Paul Digard & Reidun Twarock - Packaging signals 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets".
Collaborator Contribution University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student.
Impact Studentship commenced in October 2019
Start Year 2019
 
Description Paul Digard & Reidun Twarock - Packaging signals 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets".
Collaborator Contribution University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student.
Impact Studentship commenced in October 2019
Start Year 2019
 
Description Paul Verkade - Electron tomography and CLEM 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Nicole Doyle has performed electron tomography to analyse the three dimensional structure of membrane rearrangements induced by the expression of IBV non-structural proteins 4 or 3 and 4 in the absence of other viral components. Sample set up was performed at Pirbright and analysis was subsequently performed at University of Bristol followed by additional analysis at Pirbright.
Collaborator Contribution Paul has assisted with electron tomography data generation providing access to electron microscopes in Bristol as well as training for Nicole Doyle in performing experiments and analysing and modelling data. He is also advising Nicole while establishing correlative light electron microscopy at Pirbright.
Impact doi: 10.3390/v10090477
Start Year 2018
 
Description Pirbright-Diamond collaboration 
Organisation Diamond Light Source
Country United Kingdom 
Sector Private 
PI Contribution 50% of my time is now based at Diamond, I am considered in-house staff and can apply to use the instrumentation. I feed projects to eBIC for collaboration using advanced electron microscopy, centered around cell biology of host-pathogen interactions using advanced electron microscopy, plus potential use of Xray microscopy (on application).
Collaborator Contribution Instrument time on cryo-FIB-SEM and screening TEM (two days per month). Diamond have loaned us a plunge freezing device.
Impact No outputs yet
Start Year 2019
 
Description Professor Benedikt Kaufer 
Organisation Free University of Berlin
Country Germany 
Sector Academic/University 
PI Contribution Providing knowledge and methodologies.
Collaborator Contribution Providing reagents and methodologies to perform experiments.
Impact Two publications from this collaboration: Gurung A, Kamble N, Kaufer BB, Pathan A, Shahriar Behboudi. Association of Marek's Disease induced immunosuppression with activation of a novel regulatory T cells in chickens, PLoS Pathogens, 2017, 13 (12), e1006745. Boodhoo N, Kamble N, Kaufer BB, Shahriar Behboudi. Replication of Marek's disease virus is dependent on de novo synthesis of fatty acid and Prostaglandin E2. J Virol. 2019 Apr 10
Start Year 2019
 
Description Professor Shayan Sharif, University of Guelph, Canada 
Organisation University of Guelph
Department Department of Pathobiology
Country Canada 
Sector Academic/University 
PI Contribution Collaboration between my team and Professor Sharif lead to new finding in Avian immunology, specifically in understanding the effects of nutrients on antigen presenting cells and T cells of chicken. We took the lead in studying the effects of some nutrients (Vitamin D) on the function of chicken T cells, performed most of the experiments in our laboratory. Meanwhile, we participated in studying the effects of Vitamin D on antigen presenting cells of chicken by performing some key experiments because we had access to some specific reagents (monoclonal antibodies) recognizing molecules expressed on chicken antigen presenting cells.
Collaborator Contribution Professor Sharif team took the lead in studying the effects of Vitamin D on antigen presenting cells of chicken, and contributed to experimental plan for studying the effects on chicken T cells.
Impact Two publications in 2015 and 2016: 1. Nitish Boodhoo, Shayan Sharif, Shahriar Behboudi. 1a,25(OH)2 Vitamin D3 Modulates Avian T Lymphocyte Functions without Inducing CTL Unresponsiveness. PLoS One. 2016 Feb 24;11(2):e0150134 2. Bahram Shojadoost, Shahriar Behboudi, Villanueva AI, Jennifer Brisbin, Ali Ashkar, Shayan Sharif. Vitamin D3 modulates the function of chicken macrophages. Res. Vet. Sci. 2015 June, 100: 45-51
Start Year 2019
 
Description Provision of PRRSV field strains 
Organisation Animal and Plant Health Agency
Country United Kingdom 
Sector Public 
PI Contribution Experimental heterologous PRRSV challenge model to assess the induction of broadly neutralizing antibodies. Model to assess dendritic cell tropism of PRRS viruses
Collaborator Contribution Provision of PRRSV-1 and -2 field strains
Impact Not yet
Start Year 2016
 
Description Provision of PRRSV field strains 
Organisation Kansas State University
Country United States 
Sector Academic/University 
PI Contribution Experimental heterologous PRRSV challenge model to assess the induction of broadly neutralizing antibodies. Model to assess dendritic cell tropism of PRRS viruses
Collaborator Contribution Provision of PRRSV-1 and -2 field strains
Impact Not yet
Start Year 2016
 
Description Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies.
Collaborator Contribution this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains.
Impact The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health.
Start Year 2018
 
Description Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies.
Collaborator Contribution this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains.
Impact The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health.
Start Year 2018
 
Description Reporter PRRS viruses 
Organisation Kansas State University
Country United States 
Sector Academic/University 
PI Contribution A new application for recombinant reporter PRRS viruses i.e. to use them as a high throughput screen for neutralizing (monoclonal) antibodies. Use as tools to assess the tropism of PRRSV for dendritic cell subsets and the functional consequences.
Collaborator Contribution Provision of plasmids encoding GFP-expressing PRRSV-1 and -2.
Impact Not yet
Start Year 2016
 
Description Retroviral-mediated genetic programming of porcine memory B cells 
Organisation AIMM Therapeutics
Country Netherlands 
Sector Private 
PI Contribution Provided a novel 'model' system to test their technology to isolate novel monoclonal antibodies
Collaborator Contribution To provide their patented platform technology to genetically program porcine memory B cells to enable the isolation of memory B cells
Impact Not yet
Start Year 2016
 
Description Semiochemical-based detection of arboviral infection 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Preliminary data collection on the influence of arboviral infection on semiochemical output from sheep. These studies are being conducted as part of an unrelated animal experiment within the isolation units at Pirbright. We are carrying out the animal-based studies and collecting air entrainments from animals both pre- and post-infection. These are then decontaminated for movement to LSHTM.
Collaborator Contribution LSHTM are carrying out analysis of air entrainments using GC-MS. They will assess differences in profiles of infected vs uninfected animals and report their findings to us.
Impact Still ongoing.
Start Year 2018
 
Description SiSaf Ltd, FMDV + carriers 
Organisation SiSaf Ltd
Country United Kingdom 
Sector Private 
PI Contribution Advice on experimental design, provision of FMDV empty capsids (Alison Burman). Will do practical work in the future.
Collaborator Contribution Preparation of carrier formulations
Impact No outputs. Company did not respond to proposed experimental plan.
Start Year 2019
 
Description St Andrews 
Organisation University of St Andrews
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-investigator on BBSRC sLoLa
Collaborator Contribution Lead-investigator on BBSRC sLoLa
Impact BBSRC sLoLa ongoing
Start Year 2012
 
Description Stephen Graham collaboration on structural biology with University of Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data and sharing of experimental ideas regarding viral host range and techniques for simulating virus evolution
Collaborator Contribution Structural analysis of mutants to viral glycoproteins
Impact Journal of Virology paper on potential PPRV emergence in human populations (Abdullah et al, 2018), other papers in preparation.
Start Year 2018
 
Description Structural analysis of ASFV-host protein interactions 
Organisation La Trobe University
Country Australia 
Sector Academic/University 
PI Contribution Mutations were introduced into ASFV autophagy modulators and the effects of these were tested in cell based microscopy assays.
Collaborator Contribution Structural analysis of virus-host interactions identified residues important for binding between virus and host proteins. These residues were the residues that chosen for mutation and subsequent analysis at Pirbright
Impact One peer-reviewed paper (https://www.ncbi.nlm.nih.gov/pubmed/31461953) This is multi-disciplinary. Pirbright has expertise in virology and cell based assays. La Trobe have expertise in structural biology.
Start Year 2017
 
Description Swine haplotyping 
Organisation Gift Of Life
Country United States 
Sector Charity/Non Profit 
PI Contribution Prepared and shipped samples
Collaborator Contribution Sample analysis
Impact Data generation. Not multi-disciplinary
Start Year 2016
 
Description The GCRF One Health Poultry Hub 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia.
Collaborator Contribution Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use.
Impact Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production.
Start Year 2018
 
Description The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV).
Collaborator Contribution This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world.
Impact Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020).
Start Year 2020
 
Description The effect of the microbiota on immunity to swine infleunza 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution We wish to establish the gut and nasal microbiome in normal healthy pigs and how this is affected by influenza infection. We have collected gut samples from pigs at different stages of infection, as well as nasal swabs which we will provide to our collaborators in Surrey.
Collaborator Contribution Our collaborators in Surrey will perform the sequencing and bioinformatics analysis to determine the microbial communities present in the samples.
Impact No outcomes yet - we are in the process of analysing the samples.
Start Year 2017
 
Description Thomas Bowden - STRUBI - University of Oxford - Glycoprotein structure collaboration 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data and advice about the biological properties of viral glycoproteins, e.g. their fusion capacity with various receptors, their role in determining host-range
Collaborator Contribution Advice and technical support at the structural level supporting future project development and design
Impact No outcomes as yet
Start Year 2018
 
Description Use of fluorescent virions to isolate PRRSV-specific porcine B cells 
Organisation University of Minnesota
Country United States 
Sector Academic/University 
PI Contribution Deployment of a novel technology to facilitate isolation of PRRSV neutralizing monoclonal antibodies
Collaborator Contribution Provision of a method to fluorescently tag purified virions to label PRRSV-specific B cells
Impact None to report to date
Start Year 2016
 
Description Wilhelm Gerner 
Organisation University of Veterinary Medicine Vienna
Country Austria 
Sector Academic/University 
PI Contribution Our lab hosted Dr Gerner who brought samples for RNA-seq. My lab planned and executed the sequencing and is contributing to the analysis.
Collaborator Contribution Dr Gerner did all the animal work and cell sorting to produce the samples reading for RNA-seq
Impact None as yet, analysis is ongoing
Start Year 2019
 
Description York 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration
Collaborator Contribution Collaboration
Impact Collaboration
Start Year 2015
 
Description Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference discussed improving prevention and control of viral diseases of poultry.
Year(s) Of Engagement Activity 2018
 
Description "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference discussed prevention and control of infectious diseases affecting poultry production.
Year(s) Of Engagement Activity 2018
 
Description "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections.
Year(s) Of Engagement Activity 2018
 
Description 1st Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on "Generic approach for the development of genetic sexing strains for SIT applications" Vienna, 7-11 October 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FAO/IAEA Coordinated Research Project on exploring genetic and molecular methods of sex separation in insect pests; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field.
Year(s) Of Engagement Activity 2019
 
Description 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry.
Year(s) Of Engagement Activity 2018
 
Description 2019 Culture of Care Meeting Pirbright 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The fourth annual Culture of Care and 3Rs meeting was hosted at The Pirbright Institute on 16 October 2019. Dr Beatriz Sanz-Bernardo presented the advancements made in applying the 3Rs to lumpy skin disease research. These include refining biopsy procedures to minimise animal suffering and replacing laboratory experiments with simulations modelling host-vector interactions.
Year(s) Of Engagement Activity 2019
URL https://www.pirbright.ac.uk/news/2019/10/pirbright%E2%80%99s-2019-culture-care-meeting-focuses-anima...
 
Description 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities.
Year(s) Of Engagement Activity 2017
URL http://www.labanimaltour.org/pirbright
 
Description Animal Technician talk at Woking College 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact External talk at Woking Sixth Form College
Year(s) Of Engagement Activity 2017
 
Description Article in The Scientist Magazine following interview with Katya Zimmer (June 2019) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Journalist with The Scientist Magazine for a News Article concerning Race to Build ASFV vaccine in response to outbreaks in China/Asia
Year(s) Of Engagement Activity 2019
URL https://www.the-scientist.com/news-opinion/scientists-race-to-build-vaccine-for-african-swine-fever-...
 
Description Ash Manor GCSE Mentoring 2018 - BA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Ash Manor school challenge week science workshops 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Provide information on research activity at The Pirbright Institute and informing on pathogens infecting farmed animals.
Year(s) Of Engagement Activity 2019
 
Description BBC News story - Rinderpest virus destruction 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Pirbright Institute as one of five Rinderpest virus (RPV) holding facilities destroyed its final stocks of rinderpest virus and in doing so is leading the way for other countries to follow suit. RPV is one of only two viruses that has been eradicated and therefore is of interest to a very wide audience. The story was broadcasted on the BBC 6 O' clock news after a days filming within the high containment facility at Pirbright.
Year(s) Of Engagement Activity 2019
 
Description BBC World Service Science Programme "Science in Action" Broadcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was an broadcast with BBC World Service Science in Action Programme to inform the public about the current African swine fever situation and provide information on pathogenesis mechanisms of transmission and our research on vaccine development
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/programmes/p002vsn
 
Description BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities.
Year(s) Of Engagement Activity 2019
 
Description Big Band Science Event- AH, ER, LVC, MdP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Big Bang Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The Big Bang Near Me is a programme of regional and local Big Bang Fairs that take place all across the UK. Together with The Big Bang UK Young Scientists & Engineers Fair and The Big Bang Competition, it forms part of the wider Big Bang programme, bringing science, technology, engineering and maths (STEM) to life for young people
Year(s) Of Engagement Activity 2019
URL https://nearme.thebigbangfair.co.uk/about/
 
Description Big Bang SE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Big Bang SE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Participation (HB and MA) in Big Bang SE
Year(s) Of Engagement Activity 2019
URL https://www.thebigbangfair.co.uk/
 
Description Big Bang UK- Jennifer Simpson 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Big Bang UK is a science competition. JS acted as moderator for final projects submitted by students from across the UK.
Year(s) Of Engagement Activity Pre-2006,2019
 
Description Blenheim High School Fair - DB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Team members attended sessions at a local high school with secondary school children and those in the 6th form to talk about paths into scientific careers, sharing their experiences of working at The Pirbright Institute. Approximately 300 students attended and it stimulated increased interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Policymakers reported greater interest in deer-associated diseases including EHDV and BTV
Year(s) Of Engagement Activity 2018
 
Description Broadcast on African swine fever on BBC wolrd service "The Food Chain" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with BBC World Service "The Food Chain" on African swine fever virus.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/programmes/p05xhflj
 
Description CABI_Research activity of Avian Immunology Group at The Pirbright Institute 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Release of research activity within Avian Immunology group at The Pirbright Institute
Year(s) Of Engagement Activity 2018
 
Description CC Careers Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact MA participated in a careers fair at Collingwood College
Year(s) Of Engagement Activity 2019
 
Description Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2017
 
Description Cafe Scientifique, Reading: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2007,2017
 
Description Chair - Royal Entomological Society Session on Insect Vectors 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chaired session on Insect Vectors including selecting speakers and managing session.
Year(s) Of Engagement Activity 2019
URL https://www.royensoc.co.uk/sites/default/files/RES%20Ento%20'19%20Reg.%20Leaflet_web.pdf
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Panel discussion at the Cheltenham Science Festival in 2018
One of the biggest threats to our food security is disease of our livestock and crops. Disease affects our economy and the availability of food in our shops. Don King, Head of the World Reference Lab for Foot-and-Mouth Disease, chemical ecologist John Pickett and food systems researcher John Ingram join climate scientist Tamsin Edwards to explore the risks to the UK's food supply and how preventing and controlling these diseases keeps our store cupboards well-stocked.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science/whats-on/2018/how-safe-is-our-food-supply/
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Cheltenham Science Festival 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Attended the Cheltenham Science Festival and presented "Pandemic Live" an interactive debate on the spread of viruses in livestock. The audience were guided through the decision making processes that accompany an outbreak of an exotic livestock disease outbreak.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival- AH, ER, JC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Present at the Pirbright stand to discuss science with the public
Year(s) Of Engagement Activity 2019
 
Description Cheltenham Science festival - LB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact National science festival which Team members attended to demonstrate to the public how scientists at The Pirbright Institute can work to contain and control viral outbreaks. Over 500 people accessed the information and this stimulated increased interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Cheltenhan Science Festival - Dana Perry 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact DP helped to run a stand at the festival, questions from the general public stimulated increased interest in science and research and increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Conference session organiser at MMC2017 - Host Pathogen Interactions 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities.
Year(s) Of Engagement Activity 2012,2014,2015,2017
 
Description Coronavirus lecture MSc students (Surrey) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact A lecture was presented on the replication, cellular interactions and pathogenesis of coronaviruses to 15-20 MSc students from University of Surrey. The students were engaged and interested, answering and asking questions during the session.
Year(s) Of Engagement Activity 2016,2018
 
Description Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans.
Year(s) Of Engagement Activity 2019
 
Description Demonstrating Mathematics (Angita Shrestha) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Angita Shrestha (PhD student within Avian Influenza group) provided help in a Maths session to the new Oxford Doctoral Training Porgramme (DTP) cohort.
Year(s) Of Engagement Activity 2018
 
Description Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Development programme public consultation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Public consultation on the Pirbright development programme hosted at the Pirbright Village Hall.
Year(s) Of Engagement Activity 2017
 
Description Diamond (TT) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Diamond Light Source Open Day - explaining to general public the importance of structural biology and microscopy for understanding viruses and designing improved vaccines.
Year(s) Of Engagement Activity 2019
 
Description Diamond Light Source Open day - HJM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A public open day for Diamond Light Source, which Pirbright attended as a user of the facility to showcase research being performed at Pirbgith in collaboration with Diamond. There was a lot of interest in the fundamental research and sicussion about future plans and how it fit with the facility at Diamond.
Year(s) Of Engagement Activity 2019
 
Description Diamond open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Over 300 people visited our stand at the open day, in which we described the importance of our work for food security and public health. Children from all ages were involved and learned about viruses and played with the huge virus particle that we had produced. One of the major impact was that we described to several people why we work on some viruses that we do not have them in the UK, and the importance of the work for the UK and UK economy and public health was explained.
Year(s) Of Engagement Activity 2017
URL http://www.diamond.ac.uk/Public/VisitUs.html
 
Description EM-UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Co-organiser and speaker for UKRI supported network for electron microscopists in the UK. I was one (or two) of the founder members. Meeting has been running for 5 years. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2020
 
Description EMBO Workshop: Molecular and population biology of mosquitoes and other disease vectors: vector and disease control 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Sex determination pathway in Anopheles gambiae as a target for mosquito control" given during the meeting held on 22 - 26 July 2019 in Kolymbari, Greece. Following a presentation a request was made to give an informal seminar at the Department of Life Sciences, Imperial College, London.
Year(s) Of Engagement Activity 2019
URL https://meetings.embo.org/event/19-mosquitoes
 
Description Elle Campbell Presented her data at the 2019 Microbiology Society Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Elle Campbell gave an oral presentation at the 2019 Microbiology Society Annual Meeting on the work we were doing with fluorescently tagged IBDVs and virus factory movement.
Year(s) Of Engagement Activity 2019
 
Description Encouraging women into science and engineering STEM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact MH Visited Warwick School, Redhill to talk to secondary students about careers in STEM. A very positive outcome and well received.
Year(s) Of Engagement Activity 2018
 
Description EpiRisk Workshop, IZS Teramo, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on work done as part of EFSA lumpy skin disease working groups to inform risk modellers/epidemiologists about possible approaches
Year(s) Of Engagement Activity 2019
 
Description Epizone participation by team member 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Postdocteral scientist attended poster session at EPIZONE, "Breaking walls" Berlin 2019
Year(s) Of Engagement Activity 2019
 
Description European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork.
Year(s) Of Engagement Activity 2018
URL http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi...
 
Description Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry.
Year(s) Of Engagement Activity 2019
URL https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn...
 
Description FLI - presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Presentation of current research to the FLI - Germany to build collaborations 19/20 November 2018
Year(s) Of Engagement Activity 2018
 
Description Facebook Live: Infectious Disease Portrayals in Pop Culture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page.
Year(s) Of Engagement Activity 2017
URL https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture
 
Description Farnborough Sixth Form College Careers Fair - Chris Chiu 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact CC engaged at a careers day, and answered questions presented by sixth form students about working in science. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Farnborough futures careers event - HJM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The careers event aimed to introduce the range of careers available at Pirbright. In addition I discussed my own career progression and highlighted the range of possible careers that I could have entered. Finally, I discussed some details of the research with interested students. The students had a wide range of backgrounds and career aims but were interested to hear about the Institute and the sort of work opportunities available. Several of them planned to follow up by investigating future job opportunities at Pirbright.
Year(s) Of Engagement Activity 2019
 
Description Food security and the control of infectious disease in livestock 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A workshop was organized by myself at St Catherine's College Oxford for the duration of three days. Representative from industry, funding agencies and media (publishers) attended this workshop. Over 20 delegates from Egypt and 20 delegates from the UK attended this meeting. The purpose of this workshop/ meeting was to promote international collaborations, provide training for undergraduate students, promote the importance of managing and controlling infectious disease in livestock and public health.
Year(s) Of Engagement Activity 2016
 
Description Fox Corner Community Wildlife Committee 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Pirbright Institute representative on the Fox Corner Community Wildlife Committee - locally held meetings, every 2 months.
Year(s) Of Engagement Activity 2017
 
Description GFRA (TT) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Global Foot-and-mouth disease Research Alliance (GFRA) meeting, presentation on virus packaging and implications for vaccine production, initiated collaboration discussions between international academic and industry partners.
Year(s) Of Engagement Activity 2019
 
Description GFRA scientific meeting, Thailand 29-31/10/2019 Poster presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster title: EVALUATION OF CD4+ T-CELL RESPONSES TO VACCINATION WITH NEXT GENERATION FMD VACCINES USING TETRAMER-GUIDED EPITOPE MAPPING OF FOOT-AND-MOUTH DISEASE VIRUS CAPSID
Year(s) Of Engagement Activity 2019
 
Description Guest lecturer MSc Imaging course at University of Copenhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects.
Year(s) Of Engagement Activity 2018
 
Description Guest lecturer for PhD course in EM, University of Copenhagen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. Increase visibility of The Pirbright Institute
Year(s) Of Engagement Activity 2019
 
Description H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Focus of the conference was to improve control against infectious diseases affecting poultry and livestock.
Year(s) Of Engagement Activity 2018
 
Description H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans.
- Avian influenza virus evolution and efficacy.
-
Year(s) Of Engagement Activity 2018
 
Description Holt School Surrey. Bee meadow & A-level outreach Talk. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I discussed the importance of pollinators for biodiversity and food security with the younger students. I also discussed careers in science with A-Level students. There was good interaction and many questions surrounding both topics.
Year(s) Of Engagement Activity 2018
 
Description Host training day for APHA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact 4 users from APHA visited for training on our confocal, which is the same make and model as theirs.
Year(s) Of Engagement Activity 2019
 
Description Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Imagineering Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talked to the general public about Pirbright science and Beekeeping
Year(s) Of Engagement Activity 2019
 
Description Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dissemination of research outputs. Improvement of vaccines and diagnostics.
Year(s) Of Engagement Activity 2018
 
Description Improving vaccines and diagnostics for Avian influenza viruses affecting poultry. Presented at the International Poultry Expo "Poultry Science Conference", Lahore, Pakistan, 13-15 September 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Influenza update 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Approx. 70 scientists attended a Influenza update meeting at which our group presented an oral presentation and poster presentation on our work. These actions resulted in establishment of new collaborations for ongoing work and the initiation of a joint grant writing exercise.
Year(s) Of Engagement Activity 2018
 
Description Influenza update meeting (Pengxiang Chang) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact presented work entitled: Antigenic characterization of avian influenza H7N9 virus by in vitro immune escape mutant selection method.
Year(s) Of Engagement Activity 2018
 
Description Initiation of a mass vaccination campain ( 2018) in TamilNadu, India 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Scientists from The Pirbright Institute's Vaccine Differentiation group have recently returned from Chennai in India, where they conducted a mass peste des petits ruminants (PPR) vaccination campaign and awareness programme. They joined scientists from four specialist organisations; Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Indian Veterinary Research Institute (IVRI), National Institute of Animal Biotechnology (NIAB) and National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI).
Peste des petits ruminants (PPR), also known as goat plague, is highly contagious and infects small ruminants such as sheep and goats, causing up to 90% mortality. The disease is prevalent across large parts of Africa, the Middle East, India and China and is estimated to cost between US$1.4 billion and US$2.1 billion globally each year. In 2017, the Food and Agricultural Organization (FAO) and the World Organisation for Animal Health (OIE) introduced a global eradication programme to reduce the devastating impact PPR has on the economy and food security of affected countries.
"Over 40 vets joined our vaccination campaign in the Tanir Kulum village of Tiruvallur District, TaminNadu (close to Chennai), where we administered vaccines to over 400 sheep and goats in a single day. We also ran an awareness camp where we provided farmers and vets alike with expert guidance on diagnosing clinical signs of PPR and what measures they could take to reduce its spread", said Professor Satya Parida from Pirbright, who led the collaborative effort with Dr Dhinakar Raj from TANUVAS.
Year(s) Of Engagement Activity 2018
URL https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes...
 
Description InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures.
Year(s) Of Engagement Activity 2018
URL https://www.alphavisa.com/isessah-innovsur/2018/
 
Description Innovate Guildford (Angita Shrestha): 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact GENERAL SCIENCE
Year(s) Of Engagement Activity 2019
 
Description Innovate Guildford - DB & KC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Public science event where team members participated on a Pirbright Institute stand which contained activities to help the public understand how scientists can help to contain and control viral outbreaks. Over 500 members of the general public attended which stimulated increased interest in science and research and led to requests for more information.
Year(s) Of Engagement Activity 2019
 
Description Innovate Guildford 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically.
Year(s) Of Engagement Activity 2018
URL https://www.guildford.gov.uk/IG18
 
Description Innovate Guildford, ND 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presented at the Pirbright Institute stand discussing science performed by the Institute with the general public. The stand focussed on an exhibit on avian influenza virus but more general virology topics were also discussed including our research.
Year(s) Of Engagement Activity 2017
 
Description Innovate Guilford-AH, AA, ER, EL 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact General science festival engaging the public in the research undertaken at Pirbright
Year(s) Of Engagement Activity 2019
 
Description Inreview with Daily Telegraph about African swine fever 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with reporter from Daily Telegraph about African swine fever virus and risks to UK farmers
Year(s) Of Engagement Activity 2018
URL https://www.telegraph.co.uk/news/2018/12/12/uk-farmers-warned-alert-african-swine-fever-virus-hits-e...
 
Description Insect Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies).
Year(s) Of Engagement Activity 2017
URL https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/
 
Description Institute stand at Surrey Vet School open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Discussion with pupils interested in veterinary medicine (and their parents) about the Institute, its role and livestock disease in general.
Year(s) Of Engagement Activity 2013,2015,2016
 
Description Institute stand at Surrey Vet School open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description International Avian Respiratory Disease Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Michael presented his research at the 2018 International Avian Respiratory Disease Conference in the US to an audience of avian researchers and representatives form the poultry veterinary vaccine industry. This sparked discussion and potential future collaborations
Year(s) Of Engagement Activity 2018
 
Description International Congress of Entomology (Florida) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session and gave presentation on progress in Culicoides research. Largest ever meeting involving the Culicoides community with 100+ attendees.
Year(s) Of Engagement Activity 2016
URL http://ice2016orlando.org/
 
Description International Day of Women and Girls in Science 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I gave a quote as a STEM ambassador about why I think it is important to make sure women and girls have the same opportunities in STEM. This was shared on social media to celebrate International Day of Women and Girls in Science, a UN-led initiative.
Year(s) Of Engagement Activity 2019
 
Description Interview with Associated Press on ASFV vaccines 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Associated Press
Year(s) Of Engagement Activity 2019
URL https://apnews.com/32f84f66ce77415b96c4e90915cce6ee
 
Description Interview with Australian Broadcasting Corporation on African swine fever virus impact and vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Australian Broadcasting Corporation about ASFV impact and vaccines
Year(s) Of Engagement Activity 2019
URL https://www.abc.net.au/news/rural/2019-11-01/african-swine-fever-vaccine-development/11645366
 
Description Interview with BBC Radio 4 Inside Science 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact An interview with BBC Radio 4 Inside Science producers to inform them about African swine fever virus and our research on vaccine development
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/programmes/p05v91jq
 
Description Interview with BBC journalist for article on viral emergence in new species 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I was interviewed by Jonathon Ball who was writing an article for the BBC on the emergence of morbilliviruses in new hosts and the importance of vaccination. I helped him to contextualise the story and put him in touch with my collaborators.
Year(s) Of Engagement Activity 2020
URL https://www.bbc.co.uk/news/science-environment-50839868
 
Description Interview with CNN on African swine fever virus 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Nina Avramova from CNN International about African swine fever virus generally including transmission mechanisms and control strategies
Year(s) Of Engagement Activity 2018
URL https://edition.cnn.com/2018/10/02/health/african-swine-fever-europe-china-spread-intl/index.html
 
Description Interview with Health for Animals about African swine fever vrius vaccine development and current situation 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Interview with journalists from Health for Animals about African swine fever vaccine research published in a newsletter sent to 200 people.
Year(s) Of Engagement Activity 2018
URL https://healthforanimals.org/resources-and-events/newsletter-repository/17-disease-outbreaks.html?q=...
 
Description Interview with IEG Policay about ASFV vaccines 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Interview with Peter Rixon of IEG policy about the prospects for development of vaccines for African swine fever vrius
Year(s) Of Engagement Activity 2018
URL https://iegvu.agribusinessintelligence.informa.com/CO221819/ASF-outbreak-in-Belgium-highlights-lack-...
 
Description Interview with Journalist with The Scientist Magazine concerning ASFV vaccines and our research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Katya Zimmer Science Journalist with The Scientist Magazine published in July. This lead to follow up interviews for an in depth article on ASFV vaccines for the Scientist Magazine. In addition The Scientist published 4 Infographics images associated with the article
Year(s) Of Engagement Activity 2019
URL https://www.the-scientist.com/features/can-a-vaccine-save-the-worlds-pigs-from-african-swine-fever
 
Description Interview with New Scientist Magazine about African swine fever virus spread and vaccines 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview for an article in New Scientist about impact of African swine fever in Asia
Year(s) Of Engagement Activity 2019
URL https://www.newscientist.com/article/2222501-a-quarter-of-all-pigs-have-died-this-year-due-to-africa...
 
Description Interview with United Press about ASFV vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with United Press International on Development of ASFV vaccines
Year(s) Of Engagement Activity 2019
URL https://www.upi.com/Top_News/US/2019/07/12/World-races-to-develop-African-swine-fever-vaccine/671156...
 
Description Invited Chair at European Congress of Entomology (Naples,July) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges.
Year(s) Of Engagement Activity 2018
URL http://www.ece2018.com/scientific-programme/day-1-monday-2-july/
 
Description Invited Keynote Presentation on African swine fever and vaccine development 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Keynote presentation at China Animal Breeding and Genetics conference December Guangzhou, attended by more than 2000 delegate.
Year(s) Of Engagement Activity 2019
 
Description Invited Lecture - Antivec Network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation give on 'The Gnatwork'. 21/06/19.
Year(s) Of Engagement Activity 2019
URL https://www.gla.ac.uk/research/az/antivec/
 
Description Invited Lecture - Public Health Interest Group (London School Hygiene and Tropical Medicine) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk presented and discussion session particiation (09/04/19)
Year(s) Of Engagement Activity 2019
 
Description Invited Lecture - Wageningen University and Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk title: Culicoides-borne arboviruses in Europe - Invited lecture
Year(s) Of Engagement Activity 2019
 
Description Invited Presentation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presentations at the European PRRS Research Award ceremonies
Year(s) Of Engagement Activity 2016,2017
 
Description Invited Speaker: 33rd World Veterinary Congress, South Korea 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Provided two invited keynote presentations at the 33rd World Veterinary Congress, Incheon, South Korea, August 2017:
[1] Foot-and-mouth disease: recent outbreaks and patterns of virus spread
[2] New tools for the detection and characterisation of transboundary diseases
Year(s) Of Engagement Activity 2017
URL http://www.worldvet.org/congress.php?year=2017
 
Description Invited Talk: 8th International Veterinary Congress, Moscow, Russia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DK was invited to give a talk entitled "Global surveillance for foot-and-mouth disease: new tools and approaches to predict risks and help control outbreaks" at the 8th International Veterinary Congress, in Moscow, Russia, April 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited Talk: Indian Veterinary Institute, Bareilly, India 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact SP delivered a talk at faculty on FMD vaccine strain selection in South East Asia including India
Year(s) Of Engagement Activity 2018
 
Description Invited lecturer for MSc Biological Electron Microscopy, University of Copenhagen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects.
Year(s) Of Engagement Activity 2019
 
Description Invited oral presentation at 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited oral presentation: 'Trying to hit a moving target: Novel approaches to porcine reproductive and respiratory syndrome virus vaccine development', 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China
Year(s) Of Engagement Activity 2018
 
Description Invited presentation at the Friedrich Loeffler Institute (January; Riems) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings
Year(s) Of Engagement Activity 2019
 
Description Invited presentation: 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Invited by the British Society for Immunology to give a presentation on vaccine research at the 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens, Berkeley, UK.
Year(s) Of Engagement Activity 2018
 
Description Invited seminar at INRAE, France 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited seminar to present our recent and ongoing PRRSV research
Year(s) Of Engagement Activity 2019
 
Description Invited speaker - Moredun 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on Bioimaging capabilities at Pirbright to Moredun Institute. Attended by Head of Bioimaging at Roslin too, increased links between these institutes.
Year(s) Of Engagement Activity 2016,2018
 
Description Invited speaker - PHE Colindale 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on high containment microscopy, asking for my advice prior to the design of a new high containment microscopy facility at PHE. This sparked a discussion at the end of the meeting, and several key points of advice that I put forward for them to consider during this process. I made it clear that I am available for other discussions at a later date if needed.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker - RMS EM School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to lecture on certain aspects of electron microscopy. I provided advice on individuals difficulties they had with sample preparation. Delegates had the opportunity to ask me any questions then had relating to any sample type.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "Bluetongue virus and Schmallenberg virus - recognising the continued threat of Culicoides-borne viruses of ruminants" British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology
School of Veterinary Medicine, University of Surrey, 29th of September 2018,
Year(s) Of Engagement Activity 2018
URL https://www.bsvp.org/event/applied-ruminant-pathology-disease-investigation-diagnosis-and-surveillan...
 
Description Invited speaker VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "The Host-vector-pathogen Interface of Culicoides-borne Bluetongue Virus" at the VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 4th-5th December 2018
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at APHA surveillance meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at Imperial College 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Gave a talk on our recent research in swine influenza. Discussions with PIs at Imperial after the talk. Established collaborations.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker, Merseyside BSI Affinity group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact I described the methods we used to identifyTissue resident memory cells in pigs, which sparked a lively discussion and interest in the technique. As a result I have established two collaborations with colleagues from Liverpool.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker, Surrey University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Under- and postgraduate students attended a talk I gave at the Department of Biological Sciences in Surrey. There was a lively discussion afterwards and as a result I have established a new collaboration.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker, Vienna Veterinary School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gave a guest lecture at the Veterinary school in Vienna. There were a lot of questions and discussion after the talk. As a result established collaboration with Gerner Wilhelm's group.
Year(s) Of Engagement Activity 2019
URL https://www.vetmeduni.ac.at/de/graduate-school-pig-and-poultry-medicine/
 
Description Invited talk at Agricultural Science congress at New Delhi, India, February-2019- Use of reverse genetics to study the early pathogenesis and to develop marker vaccines for PPR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 1. In a DBT-BBSRC FADH grant, The Pirbright Institute in collaboration with four Indian partners (TANUVAS, IVRI, NIAB and NIVEDI) has developed a PPR vaccine, which will be the first to differentiate between infected and vaccinated animals (DIVA), for which a patent application has been filed. Scientists have manipulated in the genome of PPR full length cDNA and rescued the DIVA vaccine virus using reverse genetic technique. Further this vaccine has been tested in goats providing full safety and potency upon virulent virus challenge. In contrast to current vaccine, this new DIVA vaccine can differentiate between naturally infected and vaccinated animals, therefore will help in meaningful assessment of vaccine coverage and epidemiological surveillance based on serology, in turn increasing the efficiency of control programmes.
2. Little is known about the early events in the development of peste des petits ruminants (PPR) virus (PPRV) infection. The current dogma is that similar to RPV, PPRV replicates primarily in the epithelium of the respiratory tract before disseminating throughout the host. However, our investigations, using intranasal inoculation of PPRV containing GFP (Green Fluorescent Protein) to mimic natural infection, indicate this is not the case and that immune cells in the pharyngeal tonsil is the primary target. This is a ground breaking discovery which changes the PPR pathogenesis. This infectious GFP virus is made from a synthetic cDNA of field virus (PPRV/Mor-08) using reverse genetics technique under FADH grant.
The presentation sparked questions and discussions after the talk. Two PPR DIVA vaccines developed and the mechanism of PPR virus pathogenesis explained.
Year(s) Of Engagement Activity 2019
 
Description Invited talk at World Vaccine Congress, Washington DC, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussed the potential for structural vaccinology to advance livestock vaccine development including examples of FMDV, bRSV and PRRSV
Year(s) Of Engagement Activity 2019
 
Description Invited to attend and present at the RSPCA Lay members Forum, Royal Society London 10th of December 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Invited to attend to the RSPCA Lay members Forum, Royal Society London 10th of December 2018 and present on the ethical review process of animal research
Year(s) Of Engagement Activity 2018
URL https://science.rspca.org.uk/sciencegroup/researchanimals/ethicalreview/differentsystems/uk/events
 
Description JN - Woking school 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Careers Fair at a local school encouraging children to consider science as a career and representing the institute in the local community.
Year(s) Of Engagement Activity 2008
 
Description Jennifer Simpson - Big Bang Competition judge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact The Big Bang Competition recognises and rewards young people's achievements in all areas of science, technology, engineering and maths (STEM), whilst providing them with the opportunity to build their skills and confidence in project-based work. The Competition is open to all UK residents in full-time education or training.
Year(s) Of Engagement Activity 2017,2018
 
Description Jennifer Simpson - Careers Fair at Woking High School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Pirbright Institute stand at the careers fair. Speak to students interested in a career in science. Sparked questions and discussions.
Year(s) Of Engagement Activity 2018
 
Description Jennifer Simpson - Girls into STEM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Outreach activity for girls in local schools to demonstrated the variety of careers available within the STEM sector.
Year(s) Of Engagement Activity 2018
 
Description Jennifer Simpson - InFocus article on Bioimaging in high containment 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Magazine article describing the facilities for imaging in high containment at Pirbright.
Year(s) Of Engagement Activity 2018
 
Description Jennifer Simpson - Surrey MSc students visit to Pirbright 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Jenny organized a practical session where the students prepared their own samples for the confocal microscope, then they were able to image these samples using our instrument. The activities provoked questions and discussion. This session is always very warmly received by the students.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description Katy Moffat - Surrey MSc student visit to Pirbright 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Katy ran a small workshop for the students which enabled them to see the whole flow cytometry workflow. These activities provoke questions and discussions, and are always very warmly received.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description Keynote Presentation China Swine Society Conference 2019 Qingdao China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Keynote presentation at China Swine Society Conference 2019 Qingdao attended by ~1300 scientist and practitioners
Year(s) Of Engagement Activity 2019
 
Description Keynote Presentation: 6ème Journée Scientifique sur les Maladies Animales Transfrontalières, Tunisia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Provided invited keynote presentation entitled "Épidémiologie de la Fièvre Aphteuse en Afrique du Nord" at the 6ème Journée Scientifique sur les Maladies Animales Transfrontalières, Gammarth, Tunisia, November 2018.
Year(s) Of Engagement Activity 2018
 
Description Keynote Presentation: EuFMD Open session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote Presentation entitled "Global status report for foot-and-mouth disease: tracking the emergence and spread of new viral lineages" at the Open Session of the Standing Technical and Research Committee of the European Commission for the control of Foot-and-Mouth Disease, Borgo Egnazia, Puglia, Italy, October 2018.
Year(s) Of Engagement Activity 2018
URL https://intvetvaccnet.wordpress.com/2018/12/18/eufmd-open-session-2018-global-vaccine-security-borgo...
 
Description Keynote speaker - 89th IUVSTA Workshop, Poland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote seminar to 'high vacuum' community, including life scientists and physical scientists, with experience in microscopy or other high end analystical techniques. increased visibility of the Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Keynote speaker - Danish Virology Society Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was personally invited to be keynote speaker at the annual meeting of the Danish Virology Society, to talk about high containment microscopy of cell biology of host-virus interactions. The meeting was held at the State Serum Institute in Copenhagen, followed by a social evening which enabled me to add new contacts into my network. This invitation came direct from the Danish Virology Society, independent of the work I already do with the University of Copenhagen.
Year(s) Of Engagement Activity 2018
 
Description Keynote speaker - Society for Electron Microscopy annual meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented a seminar about working with microscopes in high containment. This sparked questions and discussion. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Kingdown School Warminster Wiltshire talk to 6th form students about career in science. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I presented my career path to the students to engage them on STEM careers. I had a good level of discussion and many questions.
Year(s) Of Engagement Activity 2018
 
Description LEAF open farm Sunday- JH, GM, WM, AH, KR, JS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The annual open farm day attended by businesses in the working in the farming industry in the Guilford area
Year(s) Of Engagement Activity 2019
 
Description LSD Epizone 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Oral presentation at 13th annual epizone meeting, Berlin 2019. "Risk of transmission of LSDV from experimentally infected cattle to insect vectors". Beatriz Sanz Bernardo.
Year(s) Of Engagement Activity 2019
 
Description Laboratory Science Animal association (LASA) meeting in Birmingham, Invited speaker 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Gave a presentation on the tolls we have developed to study swine influenza
Year(s) Of Engagement Activity 2018
URL http://www.lasa.co.uk/meetings/
 
Description Launch of first industry guidance on safe working with arthropods and GM insects 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Around 50 biosafety professionals and regulators including representatives from HSE attended the formal launch of the first industry guidance on working safely with arthropods and genetically modified insects on 21st April at Pirbright. This initiative originated with Sharon Webster, Chair of ISTR's Biosafety Steering Group, and was developed based on consultation with myself and members of my group with practical experience of working with arthropods in containment.
Year(s) Of Engagement Activity 2017
URL https://www.pirbright.ac.uk/news/2017/04/first-industry-guidance-safe-working-arthropods-and-gm-inse...
 
Description Laura Dunn - Female role models 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Careers day for secondary school students, with the focus on careers for women in science
Year(s) Of Engagement Activity 2018
 
Description Laura Dunn - Surrey Vet School Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Providing information about a career in research to prospective veterinary students
Year(s) Of Engagement Activity 2018
 
Description Lecture given to University of Surrey MSc Veterinary Microbiology students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup)
Year(s) Of Engagement Activity 2017
 
Description Lecture of dynamics of vector-borne diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at Univerity of Cambridge
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020
 
Description Lecture on dynamics of infectious diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture as part of MSc in Veterinary Microbiology at University of Surrey
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016,2017
 
Description Lecture on entereic coronaviruses to MSc Students (Surrey) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact A lecture was presented on the pathology, diagnosis and detection of enteric coronaviruses, including virus replication and interaction with the host. The students were engaged and asked/answered question throughout the session. We were invited to repeat the lecture for the subsequent student intakes.
Year(s) Of Engagement Activity 2015,2016,2018
 
Description Livestock Viral Diseases Pathology Slide Set 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Pip Beard (The Pirbright Institute) and Dr Sandra Scholes (Scotland's Rural College) designed a set of histology slides of tissues from livestock affected by notifiable viral diseases. The Livestock Viral Diseases Pathology Slide Set contains examples of lumpy skin disease, African swine fever, bluetongue, rift valley fever, and peste des petits ruminant. The slide set has been provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland. The aim of the slide set is to improve the ability of veterinary pathologists to diagnose exotic and notifiable livestock diseases of high consequence to the UK. The slides are also likely to be used in undergraduate veterinary training to increase the awareness of veterinary practioners of these diseases.
Year(s) Of Engagement Activity 2019
 
Description Lorin Adams (Gordon's School Careers Fair) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Lumpy Skin Disease D2R2 profile 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Provided expert opinion to the assessment (D2R2) of the risk of lumpy skin disease virus (LSDV) to the UK.
Year(s) Of Engagement Activity 2017,2018
 
Description MBPAV -presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Molecular Biology and Pathogenesis of avian viruses conference - Oxford 3-4th September 2018. Oral presentation given on drug resistant influenza viruses to approximately 50 scientist. Increased collaborative approaches following presentation.
Year(s) Of Engagement Activity 2018
URL https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2018-molecular-bio...
 
Description MMC Learning Zone - invited speaker 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Microscience Microscopy Conference, speaker at the Learning Zone - specimen preparation for life sciences. Increase the visibility of Pirbright Institute
Year(s) Of Engagement Activity 2019
 
Description Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics
Year(s) Of Engagement Activity 2018
 
Description Microbiology Society Annual Meeting, Belfast, 8-11 April 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk describing research to date - the molecular mechanism by which the Npro protein of classical swine fever virus inhibits dsRNA-induced apoptosis in infected host cells.
Year(s) Of Engagement Activity 2019
 
Description Microbiology Society Annual Meeting, Belfast, 8-11 April 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk to present project results to date - describing the interaction of foot-and-mouth disease virus (FMDV) with monocyte-derived dendritic cells (moDC).

Stimulating increased interest in science and research at The Pirbright Institute
Year(s) Of Engagement Activity 2019
 
Description Microbiology Society Annual conferences- invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Scientific talk on successful cross-species transmission of vector-borne viruses
Year(s) Of Engagement Activity 2019
 
Description Microbiology Society talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Oral presentation at Microbiology Society Annual Conference 2019
Year(s) Of Engagement Activity 2019
 
Description Microbiology Today article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018).
Year(s) Of Engagement Activity 2018
 
Description Microbiology society- 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Poster presentation of research at annual microbiology society conference. Increased interest in collaborations.
Year(s) Of Engagement Activity 2018
 
Description Miyazaki University Symposium - Oral presentation 03/12/2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation title: The N-terminal autoprotease of classical swine fever virus.

Stimulating increased interest in science and research at The Pirbright Institute
Year(s) Of Engagement Activity 2019
 
Description Mock Interview Programme Cove School- Ai, AA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Molecular determinants modulating avian influenza H7N9 virus antigenicity. Presented at The Microbiology Society Annual Conference 2019, 8-11 April ICC Belfast, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Munir Iqbal: Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description NA PRRS Symposium & Conference of Research Workers in Animal Disease - Oral and poster presentations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation title: Identification of host proteins that interact with non-structural proteins-1a and -1ß of PRRSV-1
Year(s) Of Engagement Activity 2019
 
Description Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The primary aim of this workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. The workshop provided information on emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry.
Year(s) Of Engagement Activity 2019
URL https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn...
 
Description One Health Science event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Dr Carrie Batten, Dr Don King and Dr Simon Graham, attended this event hosted by the UK CVO at the ambassadors residence in Paris, representing the Pirbright Institute. The event was to showcase the UKs capabilities in the One Health space. CVOs and other relevant stakeholders were in attendance.
Year(s) Of Engagement Activity 2019
 
Description Oral and poster presentation at European Society of veterinary Virology and EPIZONE (ESVV/EPIZONE) at Vienna, Austria 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation has been made on early events of PPR virus pathogenesis. The presentation reveled that PPR virus first taken up by the immune cells to the Pharyngeal tonsil and then to other lymph nodes before generalisation of the disease. Secondary replication happens in epithelial cells. This alters the existing believe that virus primarily replicate in the epithelial cells.
Similarly a poster presentation has been done to show the detection of nucleic acid of PPR virus during PPR eradication programme, nasal sample has been shown as the best sample for viral genome detection.
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at International Pig Veterinary Symposium and International PRRS Symposium, Chongqing, China. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation on our PRRS research at the International Pig Veterinary Symposium and International PRRS Symposium, Chongqing, China.
Year(s) Of Engagement Activity 2018
 
Description Organiser of the Animal Genetics and Diseases conference 08 - 10 May 2019 Wellcome Genome Campus, UK. Highlighting recent advances in animal genetics and genomic technologies. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I am on the organising committee for this conference. The second conference in this series will highlight recent advances in animal genetics and genomic technologies. It will bring together specialists working on the interface of genomics, genetic engineering and infectious disease with the aims of improving animal and human health and welfare.

Novel genomic technologies, mathematical modelling and quantitative genetics approaches, applied to host animals, as well as their pathogens, have transformed the understanding of animal diseases, host-pathogen interactions and epidemiology and their effects on productivity of farmed animal species and food supply chains.

This year's conference will not only put the spotlight on the immune response of host animals and epidemiology but also cover the genetics and genomics of pathogens and the impact of animal-human relationships.

We encourage registrations from researchers, breeders and technical specialists interested in learning and disseminating the latest cutting-edge techniques and methodologies across model species, wildlife, farmed animals and companion animals.
Year(s) Of Engagement Activity 2019
URL https://coursesandconferences.wellcomegenomecampus.org/our-events/animal-genetics-diseases-2019/?dm_...
 
Description Organiser/invited speaker - PhD course in EM, University of Copenhagen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects.
Year(s) Of Engagement Activity 2018
 
Description Outreach video for BTV clinical signs and transmission 2016 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Video by Simon Carpenter and Karin Darpel intended to increase awareness regarding the potential for bluetongue virus re-emergence in the UK. Circa 2000 hits to date.
Year(s) Of Engagement Activity 2016
URL https://www.youtube.com/watch?v=fwJ8zAxiLOE
 
Description Oxford DTP students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017).
Year(s) Of Engagement Activity 2017
 
Description PDRA in my group Stacey Human attending Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description PPR-Global Research and Expertise Network talk "Examining the zoonotic potential of PPRV" Vienna 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Gave a talk to the inaugural meeting of the PPR Global Research and Expertise Network (PPR GREN) at IAEA headquarters in Vienna, Austria. Participants included policy makers from the FAO and OIE.
Year(s) Of Engagement Activity 2018
 
Description Pandemic Live (Cheltenham Science Festival) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Approximately 250 attendees at a 1 hour discussion around a simulated virus outbreak scenario (Speakers Fry; Carpenter; Beard; Hatchett). Followed by question and answer session.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science/whats-on/2018/pandemic-live/
 
Description Participant in IDEAS arboviruses workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018).
Year(s) Of Engagement Activity 2017
URL http://ideas.princeton.edu/workshop-for-2017/
 
Description Participation in Understanding Animal Research Video 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interviewed and filmed by Understanding Animal Research as part of their 360 degree tour of UK animal facilities (http://www.labanimaltour.org/)
Year(s) Of Engagement Activity 2017
URL http://www.labanimaltour.org/
 
Description Participation in a meeting regarding sex determination, Duesseldorf, Germany 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation entitled "Sex determination pathway in Anopheles gambiae as a target for mosquito control" during the Nothiger meeting on sex determination in insects, Duesseldorf, 11-13 March 2019.
Year(s) Of Engagement Activity 2019
 
Description Participation in student day at the Pirbright Institute 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Student open day was participated by postgraduate students registered at several Universities, and scientists from Pirbright institute. Students were given a chance to discuss their research activities and future plans with senior scientists. Due to high interest from the students, the institute has decided to organize another open day.
Year(s) Of Engagement Activity 2016
 
Description Pengxiang Chang: Talk presentation:The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines at Microbiology Society conference, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of vaccines to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
URL https://microbiologysociety.org/event/annual-conference/annual-conference.html
 
Description Pengxiang Chang: UK-China Newton Fund (Poultry and swine) workshop at The Pirbright Institute.Oral presentation:Avian Influenza H7N9 Antigenic markers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Pengxiang Chang:Influenza update meeting. The application of CRISPR/Cas9 in the development of vaccines against avian influenza virus 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Described techniques to improve and produce new effective vaccines against viral diseases of animals and humans.
Year(s) Of Engagement Activity 2019
 
Description Pig and Poultry Fair 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Discussed Institute research with pig and poultry farmers, related industry and the general public. Received requests for more information related to research, business and studentships.
Year(s) Of Engagement Activity 2018
URL https://www.pigandpoultry.org.uk/
 
Description Pirbright Dragon Fair - MZ 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Team members attended the locally held Dragon fair where the Pirbright Institute had a stand explaining the types of research that are conducted at the Institute, making our high containment science activities transparent to the local community. Approximately 60 people engaged with the stall to learn about the science happening on their doorstep. This stimulated interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Pirbright Institute stall at LEAF Open Farm Sunday 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Hosting a Pirbright Institute stall at the LEAF Open Farm Sunday, held at the Leckford Estate, The Waitrose Farm, at Stockbridge in Hampshire on Sunday 11 June 2017.

Open Farm Sunday is a day when farms across the country open their doors to the public to show them what it means to be a farmer and for the public to see firsthand how their food is produced.

The Pirbright Institute was part of the "Science on the Farm" stand, together with BBSRC and other bioscience institutes to tell people about the work carried out and how this helps support farmers and protect the UK's food supply and the wider economy.
Year(s) Of Engagement Activity 2017
 
Description Pirbright Pride day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Set up a stand at the described our research, engaged with policymakers, industry and participants from other organizations and distributed leaflets.
Year(s) Of Engagement Activity 2015
 
Description Plenary speaker - Electron Microscopy Cryo-techniques as Tools for Elucidating Biological Processes, University of Minas Gerais, Brazil 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was personally invited to talk about imaging the cell biology of host-virus interactions. I was available throughout the associated workshop to provide advice on delegates projects relating to microscopy. These talks sparked discussions and more questions. I was able to increase my network of connections further during this visit to Brazil.
Year(s) Of Engagement Activity 2018
 
Description Population Biology of Vector-Borne Diseases Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018
Year(s) Of Engagement Activity 2018
 
Description Postdocteral scientist - oral presentation at the 12th Annual meeting of Epizone (joint with 11th International Congress for Veterinary Virology, ESVV 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Postdoctoral scientists abstract submission was selected for oral presentation. Project results obtained at the time were presented to a highly interested and engaging audience of more than 250 scientists, veterinarians, students and policymakers.
Year(s) Of Engagement Activity 2018
URL https://www.epizone-eu.net/en/Home/News/show/Abstract-book-EPIZONEESVV-meeting-now-online-.htm
 
Description Poster at IMAV 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Poster presentation at IMAV 2019: INTERNATIONAL MEETING ON ARBOVIRUSES AND THEIR VECTORS
05 - 06 September 2019
"Lumpy skin disease virus: transmission to dipteran vectors using animal and ex-vivo models" Beatriz Sanz-Bernardo
Year(s) Of Engagement Activity 2019
 
Description Poster presenation at Nipah @20 conference in Singapore 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attendance at a conference on Nipah virus, commemorating 20 years since its emergence in Malaysia and Singapore. The RA in my group presented a poster on our work developing new assays to screen the humoral response to this virus.
Year(s) Of Engagement Activity 2019
URL https://www.nipah2019.com/
 
Description Poster presentation: European Veterinary Immunology Workshop, Utrecht, The Netherlands 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact David Goldeck (post-doctoral scientist) gave a poster presentation on our studies to isolate PRRSV-neutralising monoclonal antibodies from immune pigs.
Year(s) Of Engagement Activity 2018
 
Description Poultry Stakeholders meeting hosted by Almarai, 15 October 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Engagement with Almarai Poultry. The focus of the meeting with Almarai Poultry disease control team was to share knowledge on improved vaccination and diagnostic techniques against avian influenza viruses affecting poultry production.
Year(s) Of Engagement Activity 2019
 
Description Poultry Stakeholders meeting in Kuwait city 16 October 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prevention and control of avian influenza outbreaks in poultry.
Described new vaccination and diagnostic technologies that provide more robust cross-protective immunity in emerging antigenic divergent strains of avian influenza viruses.
Year(s) Of Engagement Activity 2019
 
Description Preclinical detection of foot-and-mouth disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Interview with Veterinary Times about work on preclinical detection of foot-and-mouth disease and its potential impact on future control strategies
Year(s) Of Engagement Activity 2017
URL https://www.vettimes.co.uk/news/pre-clinical-method-a-step-closer-in-fmdv-prevention/
 
Description Predicting Pandemics (Panel discussion at Cheltenham Science Festival) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Preparation of presentation on African swine fever clinical signs and pathogenesis 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prepared a presentation on African swine fever clinical signs and pathogenesis aimed at making farmers and veterinary practitioners aware. Presentation made available publically on the APHA, DEFRA and Pirbright websites. A follow up video was made by APHA and training for APHA veterinary services is planned
Year(s) Of Engagement Activity 2018
URL http://apha.defra.gov.uk/documents/surveillance/diseases/african-swine-fever-images.pdf
 
Description Presentation at Avian viruses focussed meeting - Sept 2018 ND 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation of data as an offered paper at the molecular biology and pathogenesis of avian viruses meeting, Oxford Sept 2018.
Year(s) Of Engagement Activity 2018
 
Description Presentation at Inter-institute Bioimaging networking meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact An event was held to enable improved collaboration opportunities between scientists working with bioimaging techniques at the different research institutes within the UK. I presented data from the last 10 years describing our work characterising replication organelles induced by IBV, describing the different techniques and approaches we have used and the outlook for the future. The talk aimed to showcase the bioimaging facilities at Pirbright to encourage new collaborations.
Year(s) Of Engagement Activity 2018
 
Description Presentation at RIVR meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Oral presentation of my work to other researchers at the Recently Independent Virology Researchers meeting. I discussed my data with other researchers and potential for future collaboration.
Year(s) Of Engagement Activity 2016,2017,2019,2020
 
Description Presentation of data at Microbiology Society Annual conference 2019 - ND 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Presentation of data to scientists at the annual Microbiology Society Conference, Belfast. Following the presentation there were questions and discussion with other scientists.
Year(s) Of Engagement Activity 2019
 
Description Presentation to BBSRC Executive Board 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact I presented our research to the BBSRC Executive Board when they visited The Pirbright Institute in September 2018 and discussed the impacts of our work..
Year(s) Of Engagement Activity 2018
 
Description Presentation to The Pig Veterinary Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation to make pig veterinarians aware of African swine fever
Year(s) Of Engagement Activity 2017
URL http://www.pigvetsoc.org.uk/
 
Description Presentation: Culicoides as vectors of arboviruses 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Keynote lecture given to veterinary scientists and farmers. Performed as part of the World Buiatrics Conference 2016 and video of presentation available to members.
Year(s) Of Engagement Activity 2016
URL http://www.wbc2016.com/
 
Description Project close meeting at TANUVAS, Chennai July 2018- Delivering talk on outcome of the project 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The project team held their final workshop at TANUVAS, which concluded a four year Farmed Animal Disease and Health (FADH) grant joint funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Indian Government's Department of Biotechnology (DBT). "This grant has enabled us to collaborate with four organisations across India, and ensured that our research can be applied in the field to aid the campaign for PPR global eradication", said Professor Parida.The project covered many areas of research which are essential for understanding PPR and creating tools to help control and prevent the disease. The team have now filed a patent application for their newly developed PPR vaccine, which is the first to differentiate between vaccinated and infected animals (DIVA) - a quality that enables livestock owners to protect their animals whilst continuing to trade.
The team have also investigated how the PPR virus (PPRV) infects sheep and goats and how their immune systems respond. By inserting green fluorescent protein into virulent PPRV and administering the modified virus to goats, they demonstrated that PPRV primarily infects the tonsils, challenging the earlier belief that the virus first replicates in the respiratory tract epithelial cells. The collaborative project has also generated better diagnostic tests for use in the field and laboratory, and preliminary research has identified why some Indian breeds of goats and sheep are resistant to the disease, which could help scientists to create PPRV resistant breeds in the future.
Project partners, scientists from the University and 40 field veterinarians have joined the meeting. An awareness training has been conducted on PPR disease and eradication for these field veterinarians.
Year(s) Of Engagement Activity 2018
URL https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes...
 
Description Protecting poultry from avian influenza through passive immunisation. Presented at Foreign Experts Seminar "New strategies and new tools for the prevention and control of major poultry diseases. Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 20-22 September 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Provided information to Podcast This week in Virology about African swine fever virus spread in wild boar 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact E-mail correspondence providing advice to presenters of TWIV This week in Virology Podcast.
Year(s) Of Engagement Activity 2019
URL http://www.microbe.tv/twiv/twiv-532/
 
Description Public engagement organized at Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Set up a stand at the event, a museum at Oxford, and discussed and described research activities within the Institute with public. Set up demonstrations from some biological specimens and distributed leaflets and questionnaire.
Year(s) Of Engagement Activity 2015
 
Description Q&A statement on coronaviruses provided to Science Media Centre - HJM 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A Q&A statement on coronaviruses was provided to the science media centre, who distributed it to media outlets. Excerpt have been used in 1420 articles incuding the Daily Mail and syndicate articles. The Q&A was also used in a Pirbright Institute media statment.
Year(s) Of Engagement Activity 2020
 
Description RMS EM school - invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Royal Microscopical Society Electron Microscopy School, lecture in biological sample preparation for transmission electron microscopy. Lots of questions from delegates. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Rebecca Daines: Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza. Presented at Systems Immunology Workshop: Adaptive immune repertoires and beyond. 16th-17th January 2020. University of Surrey, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk entitled "Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza" was presented at the workshop exploring new technical advances for analysis and production of antibodies for prophylaxes and treatment of animal and humans diseases. Both academics and staff linked with animal and public health industry attended this workshop.
Year(s) Of Engagement Activity 2020
 
Description Reddit AMA (Ask Me Anything) on vector-borne diseases 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+.
Year(s) Of Engagement Activity 2017
URL https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/
 
Description Reverse genetics seminar to MSc students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A seminar was presented describing reverse genetics of viruses, including infectious bronchitis virus and the application of reverse genetics in research. The students were interested and engaged, participating in activities and asking questions. We were invited to present the seminar in subsequent years for new student intakes.
Year(s) Of Engagement Activity 2013,2014,2015,2016,2018,2019
 
Description Royal Institution Christmas Lectures Family Day - LA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Six Pirbright staff/students ran an all-day exhibit on gene editing and mosquitoes at the Royal Institution About 270 participants visited our stand; wide range of comments, questions, discussion and feedback
Year(s) Of Engagement Activity 2019
 
Description STEAMfest - HJM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact A large open day event at hosted at University of Surrey for students from a number of schools in the region to explore different scientific questions and areas of work.
Year(s) Of Engagement Activity 2019
 
Description STEAMfest - HS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Team members attended the event where a flu fighters stand was displayed demonstrating how scientists are working to rapidly detect and control avian influenza in the filed to protect food security, animal welfare and human health. Approximately 200 secondary school students engaged with the stall and this stimulated increased interest in science and research,
Year(s) Of Engagement Activity 2019
 
Description STEM Day - Speed interviews and Careers Day 2018 - BA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Scheduled Twitter session with University of Nottingham students on professional skills for biosciences 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/search?q=%23biosciprofskills
 
Description School Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Participated (AES) in Workshop at local school
Year(s) Of Engagement Activity 2019
 
Description School visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Met and discussed A level students in small groups (3 students at the time) and discussed different aspects of my work as a scientist.
Year(s) Of Engagement Activity 2015
 
Description School visit (Farnborough) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed various aspects of scientists' work.
Year(s) Of Engagement Activity 2018
 
Description Schools "Moving-on" Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Participated (AG) in schools "moving on" day
Year(s) Of Engagement Activity 2019
 
Description Science Enrichment Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact HH participated in Science enrichment day in a local school
Year(s) Of Engagement Activity 2019
 
Description Science Enrichment day at Park Mead School - ND 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact An engagment event at a local school teachin year 5 and 6 students about mosquitos and some of the work done at Pirbright.
Year(s) Of Engagement Activity 2019
 
Description Science Update to BBSRC executives 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visit from the BBSRC to discuss science highlights
Year(s) Of Engagement Activity 2019
 
Description SinoPic TT 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 'SinoPic': Structural Biology of Picornaviruses meeting in China. Generating interest and collaborations in virus structural biology within China.
Year(s) Of Engagement Activity 2018
 
Description Sir John Kingman (UKRI) visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visit to highlight Pirbright science to UKRI
Year(s) Of Engagement Activity 2019
 
Description Site tour with Department of Trade and Industry 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Tour/site visit with Department of Trade and Industry (25 people attending)
Year(s) Of Engagement Activity 2017
 
Description St Andrew's Catholic School visit to Pirbright 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact College students visited the Institute to learn about lab designs. They were given talks about the equipment and labs and then toured around the labs at Pirbright. Students were highly interested about our facilities and the work we are conducting at The Institute.
Year(s) Of Engagement Activity 2016
 
Description Surrey County Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Stall at Surrey County Show, engage with the public where they can ask any questions they have about the work we do. This sparks discussions, and an increase in knowledge of the general public. I invited the Lord Lieutenant of Surrey to our stand, with whom I have built a solid relationship. This has lead to engagement of his office with the Institute, for example the visit of HRH Princess Anne to Pirbright in 2017.
Year(s) Of Engagement Activity 2018
 
Description Surrey County Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Surrey County Show is an agricultural show in Guildford that is visited by the general public. The Pirbright Institute had a stand with various activities for visitors to take part in and explain our science to a wide audience. Giulia spent a day working on the stand and spoke with many children and adults about her work at Pirbright to change public attitudes and stimulate increased interest in research.
Year(s) Of Engagement Activity 2018
 
Description Surrey County Show - Dana Perry 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact DP helped run the stand located at the Surrey County Show, and fielded questions regarding our science from the general public, which stimulated discussion. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Surrey Open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Described the research activity of the Pirbright Institute for students from school, graduate and postgraduate students, and provided information on research facilities in the institute.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/opendays/vet
 
Description Surrey Vet School Open Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact PH helped to run a stand representing The Pirbright institute. Fielded questions from potential vet students at Surrey, and their parents/families. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Surrey Veterinary School Open Day- AA, WM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Stimulating interest in different science career paths
Year(s) Of Engagement Activity 2019
 
Description Surrey vet school open day - MJB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The event was an open day for prospective students for the University of Surrey vet school. The course includes a research placement, which can be conducted at Pirbright. Therefore there was a stand from Pirbright to describe the research we perform generally as well as a discussion of our specific research. The audience were generally interested and the information helped inform them when selecting a university course.
Year(s) Of Engagement Activity 2018
 
Description Sushant Bhat:Pirbright Dragon Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Sutton College Lecture (Enjoy your retirement) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk to group on virus outbreaks (Enjoy your retirement) - 16 people & class coordinator. Included simulation of a virus outbreak.
Year(s) Of Engagement Activity 2019
 
Description Symposium for WRLFMD 60th Anniversary 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact During November, the Pirbright Institute hosted a two-day symposium attended by over 100 FMD scientists to celebrate the 60-year anniversary of the establishment of the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD).

The meeting was opened by Christine Middlemiss (UK, Chief Veterinary Officer), Matthew Stone (Deputy Director General of the OIE) and Keith Sumption (from FAO/EuFMD). Subsequent scientific sessions reviewed the current activities of the WRLFMD (and OIE/FAO FMD Laboratory Network: https://www.foot-and-mouth.org), and discussed new opportunities to monitor, diagnose and control FMD by applying knowledge from fundamental research projects that aim to understand the pathogenesis, host responses and epidemiology of the disease.

Talks from invited speakers and WRLFMD staff were within four themes of (i) Risks & Threats, (ii) Diagnostic Innovation, (iii) Pathogenesis & Immunity and (iv) FMD Control with a Focus on Vaccination. These presentations showcased the synergy between fundamental/basic science and the on-going global surveillance activities undertaken by FMD Reference Laboratories.

In the evening, the meeting delegates (including past and present members of the WRLFMD) were royally entertained at a local hotel by after-dinner "trips down memory lane" talks from Nick Knowles and Dave Rowlands that highlighted key events and personalities that have shaped the history of work at Pirbright.
Year(s) Of Engagement Activity 2018
URL https://www.wrlfmd.org/60th-anniversary
 
Description Taiwan -UK Partnering Award: Surveillance of influenza viruses 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attended the International Flu Virus Symposium for Celebrating IPM 47th Anniversary" in Tri-Service General Hospital in Taipei, Taiwan.

Tri-Service General Hospital address:
No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan (R.O.C.)

Invited speaker for medical staff and research scientists.
Year(s) Of Engagement Activity 2019
URL https://www.cdc.gov.tw/rwd/english
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