Low Containment
Lead Research Organisation:
The Pirbright Institute
Department Name: UNLISTED
Abstract
Low containment experimental facilities support, enhance and extend the range of viruses studied at the Pirbright Institute. The primary infrastructure associated with these facilities is the BBSRC National Centre for Vaccinology, the Jenner Building, which was opened in 2016. This facility houses a wide range of groups working on strategically important endemic and exotic viral pathogens that can be handled under low containment, including Marek’s disease virus, infectious bronchitis virus and low pathogenicity animal influenzas. In addition, the Jenner building also houses groups that study the genetics and genomics of virus hosts, using state of the art technologies. This capability is nationally unique both because it supports studies of viruses not replicated elsewhere in the UK and because of its position in close proximity to High Containment Experimental Facilities in Pirbright.
Our in vivo facilities supporting avian research are housed in a temporary facility. This enables study of internationally important avian viruses within the natural host. During the term of the CCG, new facilities will be constructed on the Pirbright site, enabling expansion of this work. This includes a specified pathogen free (SPF) hatchery and rearing facility due for delivery in early 2018 and refurbishment of current high containment animal facilities to deliver a low containment Poultry Experimental Facility in late 2018.
Our in vivo facilities supporting avian research are housed in a temporary facility. This enables study of internationally important avian viruses within the natural host. During the term of the CCG, new facilities will be constructed on the Pirbright site, enabling expansion of this work. This includes a specified pathogen free (SPF) hatchery and rearing facility due for delivery in early 2018 and refurbishment of current high containment animal facilities to deliver a low containment Poultry Experimental Facility in late 2018.
Organisations
- The Pirbright Institute, United Kingdom (Lead Research Organisation)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Malaya, Malaysia (Collaboration)
- University of California Davis, United States (Collaboration)
- University of Nigeria (Collaboration)
- Horizon Discovery Group plc (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- Gift Of Life (Collaboration)
- University of Kent, United Kingdom (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- International Livestock Research Institute (ILRI) (Collaboration)
- Stanford University, United States (Collaboration)
- University of Melbourne, Australia (Collaboration)
- Aerogen (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Chinese Academy of Agricultural Sciences (Collaboration)
- University of Guelph, Canada (Collaboration)
- University of Warwick, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- University of Surrey, United Kingdom (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University of Tartu, Estonia (Collaboration)
- Polytechnic University of Valencia (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
Publications
Abdullah N
(2018)
Structure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic Potential.
in Journal of virology
Ali M
(2019)
Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015.
in Emerging infectious diseases
Altan E
(2019)
Molecular characterization of Peste des petits ruminants viruses in the Marmara Region of Turkey.
in Transboundary and emerging diseases
Ballingall KT
(2018)
Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018.
in Immunogenetics
Barber J
(2018)
Blood-feeding, susceptibility to infection with Schmallenberg virus and phylogenetics of Culicoides (Diptera: Ceratopogonidae) from the United Kingdom.
in Parasites & vectors
Baron MD
(2018)
Recent advances in viral vectors in veterinary vaccinology.
in Current opinion in virology
Baron MD
(2017)
Future research to underpin successful peste des petits ruminants virus (PPRV) eradication.
in The Journal of general virology
Batra A
(2017)
Selection of reference genes for gene expression analysis by real-time qPCR in avian cells infected with infectious bronchitis virus.
in Avian pathology : journal of the W.V.P.A
Bhat S
(2019)
Replicative fitness and transmission of G57 lineage and UDL01 like H9N2 viruses in chickens
in Access Microbiology
| Description | The key development within low containment science at The Pirbright Institute is that of providing facilities that allow handling of non-infectious and low pathogenicity agents within laboratories that are safe for the user and environment and with minimal interruptions to work. Within the first year of reporting, these objectives have been achieved to the standards within the Impact Plan for this project in the following ways: 1) Interruptions to science are within the boundaries set for the facility. 2) Pirbright remains a hub for Avian research as demonstrated by the production of publications and outreach activities. The SPF facility construction project remains on time and on budget and is due to open in 2018. 3) Relationships with the National Avian Research Facility remain open and were reinforced by meetings at both sites. 4) Bioinformatics capabilities have been strengthened significantly with expansion of computing facilities and staff, the latter provisioned from the Science Services CCG component. This has resulted in the publication of a range of papers in this area within the reporting period. 5) Significant progress has been made in opening up the low containment facilities for training and also in provision of outreach activities. 6) Insectary facilities, which have seen a significant rise in demand within the science conducted by Pirbright have been expanded via refurbishment of the IS4L facility. This is a medium term solution and dedicated facilities will be required in the longer term. |
| Exploitation Route | Building of the Avian SPF facility remains a major component of the Pirbright suite of buildings and will be a major focus of research in this field both for internal and external workers. In addition, the interim insectary facilities will enhance workers abilities to carry out research on exotic and in some cases transgenic arthropods which is key future demand for the site. Keeping pace with the health and safety and biosecurity concerns around these studies will also influence the wider community as evidenced by the close relationship with HSE on guidelines for arthropod containment. |
| Sectors | Agriculture, Food and Drink |
| Description | Minimal infrastructure downtime enabled by planned preventative maintenance on the BBSRC National Vaccinology Centre (Jenner Building) has enabled our research to be conducted under expected timescales and provided additional space for external workers. In addition, the provision of interim insectary facilities has provided a medium-term solution to a lack of space, without major disruption to work programmes, although a more permanent solution will be required in the long-term. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal,Economic,Policy & public services |
| Description | Chair of BSI Comparative Veterinary Immunology Group |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Human Infection Challenge Models for Vaccination |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Description | Netherlands Commission on Genetic Modification (COGEM) Project "Gene drives, inventory of previous research and experience" |
| Geographic Reach | Europe |
| Policy Influence Type | Gave evidence to a government review |
| Description | RCUK Engagement workshop, Cosener's House, 20-21 April 2017 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Training MSc students |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Delivered a new training session to MSc students teaching viral quantification assays. This lead to a greater understanding of laboratory techniques and academic research. |
| Description | WHO R&D Blueprint Roadmaps: Consultation on Nipah virus |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Description | Active and passive Immunity induced by aerosols |
| Amount | £100,000 (GBP) |
| Funding ID | BB/R506448/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 08/2021 |
| Description | BBSRC Newton Fund Swine and Poultry Research Initiative |
| Amount | £865,623 (GBP) |
| Funding ID | BB/R01275X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 06/2021 |
| Description | British Egg Marketing Board PhD studentship |
| Amount | £76,000 (GBP) |
| Organisation | British Egg Marketing Board |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Development of novel universal influenza vaccines |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 10/2020 |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £440,000 (GBP) |
| Funding ID | BB/R007896/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | LVIF |
| Amount | $1,500,000 (CAD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 04/2018 |
| End | 09/2020 |
| Description | NC3Rs Research Project Grant |
| Amount | £436,339 (GBP) |
| Funding ID | NC/R001138/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Private |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2019 |
| Description | Pathfinder BB/R012431/1 Grant holder: Dr Mark Fife. Grant title: chIFITM knockdown/knockout technology as a platform technology for increased vaccine yields in SPF Eggs. |
| Amount | £12,500 (GBP) |
| Funding ID | BB/R012431/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 02/2018 |
| Description | The impact of natural genetic variation on ruminant immune responses |
| Amount | £80,000 (GBP) |
| Organisation | University of Southampton |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | UK-China partnership on Global Food Security: Combating avian tumor diseases for sustainable poultry proudction |
| Amount | £382,000 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2020 |
| Title | An ex vivo IBDV infection model using a chicken primary B cell culture system |
| Description | Recently, it has become possible to culture chicken primary B cells in vitro in the presence of a soluble construct of chicken CD40L that was made at The Pirbright Institute. We have demonstrated that these chicken primary B cells can be infected with infectious bursal disease virus (IBDV). This system will be validated and expanded to other B cell tropic viruses in order to replace the use of infected chickens in research, in an NC3Rs funded grant. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Using this system, we have determined that chicken primary B cells respond to IBDV infection by inducing Type I IFN responses. However, the induction is more pronounced in cells infected with an attenuated strain compared to a very virulent strain. This is consistent with the very virulent strain down-regulating antiviral responses to a greater extent than other strains which may, in part, explain its enhanced virulence. We also observed a reduction in the expression of key genes involved in B cell proliferation and activation following IBDV infection which was only possible by using the primary B cell culture system. |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/?term=broadbent+dulwich |
| Title | CRISPR/Cas9-based gene editing of avian herpesvirus vectors to develop novel recombinant vaccines |
| Description | Development of recombinant herpesvirus vaccines are usually achieved by classical homologous recombination methods. The advent of new genome editing tools has enabled its application on avian herpesvirus vaccine strains to develop new recombinant vaccines potentially capable of expressing protective antigens from multiple pathogens |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The major impact will be in the generation of novel vaccines that can simultaneously protect against multiple avian diseases |
| URL | http://www.poultryworld.net/Health/Articles/2016/12/Is-GM-technology-the-future-of-poultry-vaccines-... |
| Title | Developed an in vivo infection model to generate highly pathogenic bovine RSV for challenge studies. Developed an accompanying in vitro titration method to calculate yield of virus produced. |
| Description | Developed an in vivo infection model to generate highly pathogenic bovine RSV for challenge studies. Developed an accompanying in vitro titration method to calculate yield of virus produced. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Will help use and improve the calf challenge model of bovine RSV for vaccine testing. |
| Title | Development of tetramers to study immune responses in pigs |
| Description | The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume. It is also an important vector in the birds to human infection cycle. A major drawback of the current pig model is the inability to analyze antigen-specific CD8+ T-cell responses, which are critical to respiratory immunity. We addressed this knowledge gap using an established in-bred pig model with a high degree of genetic identity between individuals, including the MHC (Swine Leukocyte Antigen (SLA)) locus. We developed a toolset that included long-term in vitro pig T-cell culture and cloning and identification of novel immunodominant influenza-derived T-cell epitopes. We also generated structures of the two SLA class I molecules found in these animals presenting the immunodominant epitopes. These structures allowed definition of the primary anchor points for epitopes in the SLA binding groove and established SLA binding motifs that were used to successfully predict other influenza-derived peptide sequences capable of stimulating T-cells. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Peptide-SLA tetramers were constructed and used to track influenza-specific T-cells ex vivo in blood, the lungs and draining lymph nodes. Aerosol immunization with attenuated single cycle influenza viruses (S-FLU) induced large numbers of CD8+ T-cells specific for conserved NP peptides in the respiratory tract. Collectively, these data substantially increase the utility of pigs as an effective model for studying protective local cellular immunity against respiratory pathogens. |
| Title | Established a method to immortalize bovine antigen presenting cells |
| Description | Established protocols to prepare lentiviruses expressing the proto-oncogenes Bmi1 and hTERT. Established protocols to transduce and generate immortal bovine antigen presenting cells derived from peripheral blood monocytes. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | This is the first successful attempt at generating bovine immortal monocytic cell lines. This method can also be applied to immortalize B cells. This will result in reducing the number of animals used in experimentation and considerably reduce costs. |
| Title | Established human T cell lines expressing bovine WC1 genes for the analysis of WC1 signal transduction pathways. |
| Description | Established human Jurkat T cells expressing bovine the bovine gammadelta WC1 co-receptor |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | This cell line will help determine the function of the WC1 co-receptor in gammadelta T cell activation and function. |
| Title | Generated a MHC-defined bovine monophagocytic cell line. |
| Description | Using the method described above, successfully generated one MHC-defined bovine monophagocytic cell line (A18) which expresses and single classical MHC gene (HD6). |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | Will help reduce the number of animals used in experimentation. Will help resolve antigen presentation pathways in bovine cells and using bovine pathogens. Will help understand T cell activation pathways using MHC matched and mis-matched cells. Will help investigate bovine NK cell activation. |
| Title | Generated monophagocytic reporter cell lines to study the NF-kB signaling pathway |
| Description | Generated human monophagocytic cells expressing alkaline phosphatase reporter gene under a NF-kB promoter sequence. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | This cell line is helping determine the role of RSV genes in immune modulation of monophagocytic cells in response to RSV infection. |
| Title | IBDV Reverse Genetics System |
| Description | We have developed a reverse genetics system for IBDV. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | We have used the reverse genetics system to generate recombinant IBDVs and chimeric recombinant IBDVs that contain genes from classical and very virulent strains of IBDV in the background of a cell culture adapted attenuated strain. This will enable us to study the effect of individual virus genes on pathogenicity. |
| Title | Optimisation of chicken kidney cell culture preparation |
| Description | We have optimised the method of extracting kidneys and preparing chicken kidney (CK) cell cultures from chickens. CK cells are used for in vitro assays to study avian viruses, in particular infectious bronchitis virus. |
| Type Of Material | Cell line |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This has increased the yield of viable cells and the quality of the cell cultures. We can now obtain the number of cells we require using fewer chicken kidneys, therefore requiring fewer chickens to be culled. This is an important development for the 3Rs. We hope to publish this method for others' information. |
| Title | Stable chicken cell lines overexpressing chicken IFITM1,2 and 3 |
| Description | In collaboration with Mark Fife, we have produced chicken stable cell lines overexpressing chicken IFITM1,2, 3 and a mutant chicken IFITM3 lacking palmitoylation sites. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | These cell lines will be used to evaluate the effect of the IFITM proteins on the replication of different viruses, including IBDV. |
| Title | method for identification of lung Tissue resident memory cells in pigs |
| Description | Recent overwhelming evidence indicates the importance of local tissue-resident memory T cells (TRM) in protective immunity. Most work on TRM has been performed in mice and the TRM defined as inaccessible to intravenously administered anti-T cell antibody. However there are very few data on TRM in large animals. For the first time we have defined TRM in the pig influenza model. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The identification of TRM and their robust protective capacity in site-specific infection has provided a new paradigm by which to assess T cell-mediated responses and an important new target for vaccine design. Since swine are an economically important species, are used as a large animal model for human infection and play a key role in the emergence of novel and potentially zoonotic influenza viruses, the identification of TRM in pigs will allow us to study their role in immunity to swine influenza.and how best to induce them by immunisation. |
| Title | replication competent recombinant split-GFP infectious bursal disease virus |
| Description | We have generated a replication competent recombinant split-GFP infectious bursal disease virus (IBDV) where a small GFP11 molecule is tagged to the virus polymerase (VP1) to make IBDV-VP1-GFP11. Infected cells that express the GFP1-10 molecule fluoresce green when the GFP11 tag complements the GFP1-10. The IBDV-VP1-GFP11 colocalises with VP3 and dsRNA and therefore is likely to be present at the sites of virus replication. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This tool can be used to study IBDV replication complex development in infected cells. |
| Title | E-MTAB-5947- Transcription profiling by array of differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV) |
| Description | Microarray data submitted to ArrayExpress from chicken primary B cells infected with a very virulent and attenuated strain of IBDV. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | This is the first ever microarray data of chicken primary B cells infected with IBDV and will be of use to other researchers in the area of B cell biology or IBDV virology |
| URL | https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-5947/ |
| Description | Aerosol delivery of vaccines and therapeutics |
| Organisation | Aerogen |
| Country | Ireland |
| Sector | Private |
| PI Contribution | Developed the pig influenza model which is a natural host pathogen system |
| Collaborator Contribution | Provided expertise and equipment for aerosol delivery |
| Impact | Successfully delivered vaccines by aerosol |
| Start Year | 2015 |
| Description | BBSRC-UC Davis workshop, 16-18 October |
| Organisation | University of California, Davis |
| Department | UC Davis College of Biological Sciences |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities. |
| Collaborator Contribution | Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities. |
| Impact | Discussion of potential joint publications and grant applications; no tangible impacts yet. |
| Start Year | 2017 |
| Description | BBSRC-UC Davis workshop, 16-18 October |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities. |
| Collaborator Contribution | Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities. |
| Impact | Discussion of potential joint publications and grant applications; no tangible impacts yet. |
| Start Year | 2017 |
| Description | Bridget Penman |
| Organisation | University of Warwick |
| Department | School of Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are providing genetic data and diversity measures of MHC and associated receptors to inform the modelling efforts to elucidate which selection pressures are the main drivers for the types of diversity we see in extant species. |
| Collaborator Contribution | They are experts in mathmatical modelling and will provide data to help explain genetic diversity in cattle. |
| Impact | Not yet |
| Start Year | 2017 |
| Description | Derek Bickhart-USDA |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Beltsville Agricultural Research Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our group has provided the genomic framework of the cattle NK cell regions and the biological input. |
| Collaborator Contribution | The ARS group has used our data as a framework to map and predict cattle SNPs for variable immune traits using their whole genome data |
| Impact | Research application based on preliminary data to a BBSRC-NIFA call. This collaboration is multi-disciplinary combining molecular biology and computational biology |
| Start Year | 2014 |
| Description | Development of tetramers in the Babraham pig model |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developed the aerosol delivery method of vaccine and provided material (spleen, BAL and blood) from inbred animals (Babraham pigs) following immunisation with the candidate universal vaccine, S-FLU. |
| Collaborator Contribution | Developed porcine influenza specific class I tetramers and provided the epitope map of Babrahams S-Flu responses to NP, M1, M2, PB1 and PB2 that could be presented by SLA-1 or SLA-2 Grew pig T cell clones for the first time in 30 years. |
| Impact | Multidisciplinary - immunology, virology, protein chemistry. Paper not yet published |
| Start Year | 2014 |
| Description | Dr Michael Skinner, Imperial College London |
| Organisation | Imperial College London |
| Department | Department of Primary Care and Public Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We aim to compare the host transcriptional response of primary chicken B cells infected with different strains of IBDV of varying virulence. We have the specialist reagents and expertise in house that are required to culture primary chicken B cells, and we have access to different strains of IBDV. |
| Collaborator Contribution | Dr Michael Skinner and his team at Imperial College London have the expertise and facilities to generate and analyse RNA-Seq data in order to determine host transcriptional responses. This is required in order to complete the aim of the project. |
| Impact | Further funding: PhD studentship (£102,800) - Dr Andrew Broadbent at The Pirbright Institute and Dr Michael Skinner at Imperial College London are joint supervisors for a PhD student working on this project. Further Funding: Houghton Trust (£8,000)- Dr Andrew Broadbent was awarded a Houghton Trust Small Research Grant to contribute to this project. |
| Start Year | 2014 |
| Description | Efficacy of a candidate universal influenza vaccine, S-FLU. |
| Organisation | University of Oxford |
| Department | Radcliffe Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Tested the immunogenicity and efficacy of a candidate universal influenza vaccine, S-FLU, in pigs. For the first time we demonstrated that S-FLU when administered by aerosol can reduce viral load in nasal swabs and lung in pigs after influenza virus challenge. We have shown that the most efficient way to administer this vaccine is by aerosol. |
| Collaborator Contribution | Professor Alain Townsend has developed the S-FLU vaccine. |
| Impact | The most efficient way to induce immune response in the lung is after aerosol delivery of LAIV vaccines in pigs. The most efficient way to induce cross-protective immunity is by aerosol delivery of S-FLU to the lungs of pigs |
| Start Year | 2014 |
| Description | Engineering mosquitoes for reduced vector competence for chikungunya virus |
| Organisation | University of Malaya |
| Department | Department of Medical Microbiology |
| PI Contribution | Developed joint research programme, led successful application for funding, coordinate programme. |
| Collaborator Contribution | Various specific strands of research, and group discussions about results, conclusions, research progress and future activities. |
| Impact | reported under funding |
| Start Year | 2016 |
| Description | Engineering mosquitoes for reduced vector competence for chikungunya virus |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Developed joint research programme, led successful application for funding, coordinate programme. |
| Collaborator Contribution | Various specific strands of research, and group discussions about results, conclusions, research progress and future activities. |
| Impact | reported under funding |
| Start Year | 2016 |
| Description | Engineering mosquitoes for reduced vector competence for chikungunya virus |
| Organisation | University of Tartu |
| Department | Institute of Technology |
| PI Contribution | Developed joint research programme, led successful application for funding, coordinate programme. |
| Collaborator Contribution | Various specific strands of research, and group discussions about results, conclusions, research progress and future activities. |
| Impact | reported under funding |
| Start Year | 2016 |
| Description | Generation of immortalised bovine antigen presenting cells |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Using a lentivirus vector expressing proto-oncogenic genes, we generated MHC-defined immortal bovine antigen presenting cells that can be used in antigen presentation studies or virus-host interaction studies in the future. |
| Collaborator Contribution | The University of Surrey provided several lenvirus vectors and preparation for immortalization studies. |
| Impact | A publication in progress titled "Generation of immortal bovine antigen presenting cells" and the generation of a library of MHC-defined bovine cell lines. |
| Start Year | 2017 |
| Description | Horizon Discovery Ltd Cambridge Research Park, United Kingdom |
| Organisation | Horizon Discovery Group plc |
| PI Contribution | Verify IFITM knock-out cell by qPCR and immuno-blotting. Verification of further knock-out cell lines by DNA sequencing, immuno-blotting and qPCR Cell infection with Avian Influenza Viruses Assess the viral titre of cells infected with Influenza Viruses in K/O and wildtype cells. Quantitative analysis of viral infection in IFITM K/O cells Demonstrate increased AIV viral titres at lab scale and estimation of what this may equate to with respect to vaccine dose yields. Analysis of IFITM K/O cell lines permissivity to a range of additional animal viruses (Relevant to the LVIF). Milestone 7: Demonstrate permissivity increased and viral titres for a range of LVIF relevant viruses in the edited cell lines. |
| Collaborator Contribution | Develop a CRISPR/cas9 gene editing system to specifically target the chIFITM locus in avian cell culture |
| Impact | Grant funding |
| Start Year | 2017 |
| Description | ILRI Research Collaboration (Kenya, March 2017) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Exchange of ideas and samples for indigenous breeds of livestock |
| Collaborator Contribution | Contributed samples for analysis. |
| Impact | Analysis of indigenous breed genomic sequences for Immune function genes. |
| Start Year | 2017 |
| Description | Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Collaborator Contribution | My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Impact | Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017. |
| Start Year | 2017 |
| Description | Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. |
| Organisation | University of Kent |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Collaborator Contribution | My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Impact | Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017. |
| Start Year | 2017 |
| Description | Identification of human orthologues of bovine Workshop Cluster 1 genes |
| Organisation | University of Oxford |
| Department | Nuffield Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The Workshop Cluster 1 (WC1) gene family encodes a group of proteins thought to be involved in immune recognition. These genes are exclusively expressed on T cells expressing the gamma and delta T cell receptor and are well characterized in the bovine system. We have began investigating the presence and expression of WC1 on human cells using co-immunoprecipitation and mass spectrometry analysis of putatitve human WC1 genes. |
| Collaborator Contribution | The Univ. of Oxford has developed a pipeline to identify protein fragments using mass spectrometry and bioinformatics from putative proteins from which little or no information is currently known. This pipeline has been applied to identify putative human WC1 proteins obtained from co-immunoprecipitation/mass spectrometry studies. |
| Impact | The identification of one human WC1 gene/protein. A publication in progress titled "Identification of the human orthologue of a Workshop Cluster 1 gene expressed on gammadelta T cells" |
| Start Year | 2017 |
| Description | Imperial |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint supervision of PhD student |
| Collaborator Contribution | Joint supervision of PhD student |
| Impact | One successful completed PhD student. Papers published or in preparation. Another PhD student in progress. |
| Start Year | 2010 |
| Description | Investigating the role of the SH protein of RSV in the duration of immunity |
| Organisation | Imperial College London |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided initial data supporting the hypothesis that the small hydrophobic protein of bovine respiratory syncytial virus regulates the host's immune response by modulating the transcription factors NF-kB and STAT1 in bovine cells |
| Collaborator Contribution | Based on our results, Imperial has began investigating the role of the small hydrophobic protein of human respiratory syncytial virus on human cells. |
| Impact | Publication in progress titled "Regulation of the B cell activating factor BAFF by the small hydrophobic protein of respiratory syncytial virus". |
| Start Year | 2017 |
| Description | Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Shanghai Veterinary Research Institute |
| PI Contribution | Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector |
| Collaborator Contribution | Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/). |
| Impact | organised joint meeting in China and the UK to discuss on challenges and opportunities |
| Start Year | 2017 |
| Description | JN - Preparation of capped mesoporpus silica nanoparticles |
| Organisation | Polytechnic University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments |
| Collaborator Contribution | Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments. |
| Impact | Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples |
| Start Year | 2016 |
| Description | JS - Production of monoclonal antibodies that recognise FMDV VP4 from mouse spleens |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | VLPs displaying the N-terminal 15 amino acids of FMDV were designed and produced at The Pirbright Institute and then mice were immunised with them. The spleens of the immunised mice were harvested and splenocytes stored. The response to the VP4 sequence was checked by ELISA and the mouse with the best response was selected to send the splenocytes for monoclonal production. |
| Collaborator Contribution | The collaborators took the splenocytes obtained from the mouse experiments and carried out the fusions. They then screened the supernatants for positive wells that detected the VP4 sequence. |
| Impact | Positive wells have been identified indicating some monoclonals that are specific for VP4 have been generated. These will be further screened for ability to recognise virus and to neutralise infection. |
| Start Year | 2017 |
| Description | Leeds FBS |
| Organisation | University of Leeds |
| Department | Leeds Institute of Molecular Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research |
| Collaborator Contribution | Research and student supervision |
| Impact | Research |
| Start Year | 2009 |
| Description | Mosquito Interest Group |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques. |
| Collaborator Contribution | Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques. |
| Impact | Exchange of practical techniques, for instance in tracking oviposition of individual mosquitoes. Brainstorming for projects and papers, resulting in a GCRF VBD network proposal (which passed the first review but was not funded in the second) and an informal collaboration (which was intended for submission to UK-Thai call in 2017 but Thai partner was not eligible). Exchanges of colony strains of insects planned this month. |
| Start Year | 2016 |
| Description | Mucosally Associated Invariant T cells (MAIT) in pig influenza model |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identified MAIT cells in pig Influenza model. Provide samples from infected and immunised protected animals |
| Collaborator Contribution | Provide expertise in characterising MAIT: development of tetramer; Zell scanner technology allowing high resolution studies of cell phenotype and functions |
| Impact | Joint PhD studentship with Paul Klenerman, University of Oxford |
| Start Year | 2016 |
| Description | Nicolas Locker - Investigation of translation regulation by infectious bronchitis virus |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team provide experience in molecular virology and cellular interactions of infectious bronchitis virus including previous experience of IBV accessory proteins regulating cellular translation. A PhD student works jointly between our labs. |
| Collaborator Contribution | Dr Locker's team provide expertise in viral regulation of cellular translation and stress granule signalling. Dr Locker is also providing protocols, advice and training for techniques including ribopuromycylation and ribosome profiling. A PhD studentworks jointly between our labs. |
| Impact | PhD student funding (studentship commenced Oct 2017) - Control of host cell translation by infectious bronchitis virus |
| Start Year | 2016 |
| Description | Oxford |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Collaborator Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Impact | Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging |
| Start Year | 2008 |
| Description | Oxford University Collaborations |
| Organisation | University of Oxford |
| Department | Big Data Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific discussion, collaboration and manuscript preparation |
| Collaborator Contribution | Scientific discussion, collaboration and manuscript preparation |
| Impact | Manuscript in preparation |
| Start Year | 2017 |
| Description | Parham Lab at Stanford |
| Organisation | Stanford University |
| Department | School of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our group designed the experiments and generated a majority of the data. We also led the analysis of the data and writing of the manuscripts |
| Collaborator Contribution | The Parham lab is the leading group worldwide in the evolutionary study of NK cell receptors and MHC class I. This group generated part of the data and helped in the analysis, interpretation and manuscript preparation |
| Impact | Definition of the Cattle Killer Cell Igndash like Receptor Gene Family: Comparison with Aurochs and Human Counterparts Nicholas D. Sanderson, Paul J. Norman, Lisbeth A. Guethlein, Shirley Ellis, Christina Williams, Matthew Breen, Steven D. E. Park, David A. Magee, Farbod Babrzadeh, Andrew Warry, Mick Watson, Daniel G. Bradley, David E. MacHugh, Peter Parham, and John A. Hammond. Journal of Immunology, Dec 15, 2014; 193 (12) This collaboration is not multi-didciplinary |
| Start Year | 2009 |
| Description | Professor Sahyan Sharif, University of Guelph, Canada |
| Organisation | University of Guelph |
| Department | Department of Pathobiology |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Collaboration between my team and Professor Sharif lead to new finding in Avian immunology, specifically in understanding the effects of nutrients on antigen presenting cells and T cells of chicken. We took the lead in studying the effects of some nutrients (Vitamin D) on the function of chicken T cells, performed most of the experiments in our laboratory. Meanwhile, we participated in studying the effects of Vitamin D on antigen presenting cells of chicken by performing some key experiments because we had access to some specific reagents (monoclonal antibodies) recognizing molecules expressed on chicken antigen presenting cells. |
| Collaborator Contribution | Professor Sharif team took the lead in studying the effects of Vitamin D on antigen presenting cells of chicken, and contributed to experimental plan for studying the effects on chicken T cells. |
| Impact | Two publications in 2015 and 2016: 1. Nitish Boodhoo, Shayan Sharif, Shahriar Behboudi. 1a,25(OH)2 Vitamin D3 Modulates Avian T Lymphocyte Functions without Inducing CTL Unresponsiveness. PLoS One. 2016 Feb 24;11(2):e0150134 2. Bahram Shojadoost, Shahriar Behboudi, Villanueva AI, Jennifer Brisbin, Ali Ashkar, Shayan Sharif. Vitamin D3 modulates the function of chicken macrophages. Res. Vet. Sci. 2015 June, 100: 45-51 |
| Start Year | 2014 |
| Description | Research Collaboration with Nigeria (23rd - 28th January 2017) |
| Organisation | University of Nigeria |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | Analysis of rare breed indigenous chicken in Nigeria. |
| Collaborator Contribution | Helped with sampling and background information of the breed. |
| Impact | Analysis is ongoing. |
| Start Year | 2017 |
| Description | Swine haplotyping |
| Organisation | Gift Of Life |
| PI Contribution | Prepared and shipped samples |
| Collaborator Contribution | Sample analysis |
| Impact | Data generation. Not multi-disciplinary |
| Start Year | 2016 |
| Description | The Roslin Institute |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have been working with several groups using our molecular and genetic data to help understand cattle cellular immunology. We have also hosted a visiting scientist to provide training in molecular techniques and data analysis, This has continued and now includes members of the Centre for Tropical Livestock Health and Genetics where we are engaged in sample sharing and maximising the value of genetic data by linking different sources as much as possible. |
| Collaborator Contribution | Our partners have provided data and reagents as well as intellectual input to help us translate genetic diversity into functional diversity |
| Impact | This collaboration is multi-disciplinary, although largely immunology and associated genetics is also involves bioinformatics |
| Start Year | 2011 |
| Description | The effect of the microbiota on immunity to swine infleunza |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We wish to establish the gut and nasal microbiome in normal healthy pigs and how this is affected by influenza infection. We have collected gut samples from pigs at different stages of infection, as well as nasal swabs which we will provide to our collaborators in Surrey. |
| Collaborator Contribution | Our collaborators in Surrey will perform the sequencing and bioinformatics analysis to determine the microbial communities present in the samples. |
| Impact | No outcomes yet - we are in the process of analysing the samples. |
| Start Year | 2017 |
| Description | University of Glasgow collaborations |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific discussion and reagent sharing contributing to grant applications and active research projects |
| Collaborator Contribution | Scientific discussion and reagent sharing contributing to grant applications and active research projects |
| Impact | Successful MRC grant application |
| Start Year | 2015 |
| Title | Developed a "Vaccine PacMan" game on Scratch |
| Description | Developed a "Vaccine PacMan" game on Scratch to teach school children and the general public about long-term and short-term immunity work. Based on the classical PacMan game, Vaccine PacMan was designed to demonstrate duration of immunity when PacMan eats one of 4 defined "super pills". When PacMan eats a super pill, he becomes immune to the ghosts for a defined number of seconds. The four pills (vaccines) confer PacMan different lengths of immunity against the ghosts. The objective of the game is to find which pill gives the longest duration of immunity and use it to finish the game. This tool can be used to demonstrate the concepts of vaccination and duration of immunity. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2016 |
| Impact | Educational apps and electronic games have acquired a prominent role in teaching basic skills and concepts. When used as a complement to traditional methods of learning, these educational tools can improve children's classroom performance. It is often a challenge to make learning fun for children and sometimes traditional methods of learning aren't always engaging therefore it is important to try and capture their attention with creative tech-based methods of learning such as science games which can make learning more fun. Creating a PacMan-type game which is associated with such an iconic and popular game can engage children which in turn improves classroom performance, enhances technical skills and provides exposure to alternative methods of learning. |
| Description | 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.labanimaltour.org/pirbright |
| Description | A talk at Surrey University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Under- and postgraduate students attended a talk I gave at the Department of Biological Sciences in Surrey. There was a lively discussion afterwards and as a result I have established a new collaboration. |
| Year(s) Of Engagement Activity | 2018 |
| Description | A talk at a symposium entitled: Using the 3Rs to support good science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk at a Symposium held at The Pirbright Institute entitled: "Using the 3Rs to support good science". The talk was entitled: "A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry" |
| Year(s) Of Engagement Activity | 2017 |
| Description | A talk at the British Poultry Diseases Group meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The Poultry Diseases Group meet quarterly and is comprised of representatives from private veterinary practices, vaccine and pharmaceutical industries, and the Animal and Plant Health Agency (APHA). I gave a talk at one of the meetings outlining my research to date and future directions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Amy Lewis, The Scientist, 15/08/2017 re gene drive and Predator Free NZ 2050 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided information and quotes for article on potential use of gene drives as part of New Zealand effort to eradicate invasive predators |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.the-scientist.com/?articles.view/articleNo/50180/title/Driving-Down-Pests/ |
| Description | BBSRC website article: Halloween |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on BBSRC website: Halloween Creepy Crawlies |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bbsrc.ac.uk/news/fundamental-bioscience/2017/171031-f-uk-creepiest-creepy-crawlies/ |
| Description | Biotech YES, Syngenta Jealott's Hill, 05 Oct 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Teams of postgraduate students from a number of universities and institutes attended talk as part of Biotech YES (Young Entrepreneurs' Scheme). Follow-up discussion influenced several aspects of their approach to entrepreneurship both within the competition and more generally |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
| Description | CBD Open-ended online forum on synbio 06-10/2017 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | UN Convention on Biodiversity. Policy- discussion on synthetic biology: nominated participant in the Open Ended Online Forum on Synthetic biology as established in decision XII/24 of the Conference of the Parties to the Convention on Biological Diversity (COP) and extended in COP decision XIII/17 which ran from June to Oct 2017 (approx.) |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://bch.cbd.int/synbio/open-ended/discussion/ |
| Description | Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cafe Scientifique, Reading: "How insects spread viruses" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions. |
| Year(s) Of Engagement Activity | 2007,2017 |
| Description | Caroline Seydel Genetic Literacy Project re GM mosquitoes/gene drive/Zika |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided background material and quotes for article on GM mosquitoes and control of Zika virus. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://geneticliteracyproject.org/2018/01/29/waging-war-mosquito-split-gene-drive-hinder-spread-zik... |
| Description | Centre of excellence for research on avian diseases (CERAD) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I was invited to present my work at the UK-China Centre of excellence for research on avian diseases (CERAD) meeting attended by researchers from UK, China and Thailand. There was lots of discussion about the research and future directions, including potential collaborations. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines. Presented at as PI of the ZELS project at ZELS grant holders and Stakeholders meeting in Hanoi, Vietnam 23th-24th January 2017. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engagement and dissemination of research outcome to representatives of research funding bodies such as Department for International Development (DFID), Medical Research Council (MRC) and the researchers working on different research projects funded by BBSRC under Zoonoses and Emerging Livestock Systems (ZELS). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Conference session organiser at MMC2017 - Host Pathogen Interactions |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities. |
| Year(s) Of Engagement Activity | 2012,2014,2015,2017 |
| Description | DARPA visit April 2017 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Hosted visit by US funding agency programme manager to The Pirbright Institute |
| Year(s) Of Engagement Activity | 2017 |
| Description | Diamond open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Over 300 people visited our stand at the open day, in which we described the importance of our work for food security and public health. Children from all ages were involved and learned about viruses and played with the huge virus particle that we had produced. One of the major impact was that we described to several people why we work on some viruses that we do not have them in the UK, and the importance of the work for the UK and UK economy and public health was explained. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.diamond.ac.uk/Public/VisitUs.html |
| Description | EM-UK: A national network for electron microscopists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Founder and Chair of EM-UK, a national network (with international participants) for electron microscopists. Includes a one or two day meeting with invited speakers, and email discussion list for questions, comments, advertising courses, advertising jobs. It has proved very popular with over 200 people registering for the discussion list, and 90+ delegates at each meeting. Administration is handled by the Royal Microscopical Society. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | Ewen Callaway Nature 08/01/2018 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided expert background information for article in Nature regarding engineering species barriers, described by journalist as "very helpful" in followup email. |
| Year(s) Of Engagement Activity | 2018 |
| Description | FAO/IAEA Coordinated Research Programme on methods of sex separation in mosquitoes; Research coordination meeting Bangkok 19-23 February 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FAO/IAEA Coordinated Research Programme on exploring genetic, molecular, mechanical, and behavioral methods of sex separation in mosquitoes; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field. |
| Year(s) Of Engagement Activity | 2013,2015,2016,2018 |
| Description | Facebook Live: Infectious Disease Portrayals in Pop Culture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture |
| Description | Food security and the control of infectious disease in livestock |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A workshop was organized by myself at St Catherine's College Oxford for the duration of three days. Representative from industry, funding agencies and media (publishers) attended this workshop. Over 20 delegates from Egypt and 20 delegates from the UK attended this meeting. The purpose of this workshop/ meeting was to promote international collaborations, provide training for undergraduate students, promote the importance of managing and controlling infectious disease in livestock and public health. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Gnatwork Website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | New website established to act as focalpoint of project. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.gnatwork.ac.uk/ |
| Description | Holly Kernot, Veterinary Times, 13/06/2017 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussed potential of manipulating mosquito sex determination genes as tools for novel mosquito genetic control approaches. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.vettimes.co.uk/news/study-to-be-transformational-in-mosquito-control-strategies/ |
| Description | Human Infection Challenge Models Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | HIC-Vac is an international network of researchers who are developing human infection challenge (HIC) studies to accelerate the development of vaccines against pathogens of high global impact. The goal is to foster an engaged and interactive community of international researchers to promote open sharing of knowledge and expertise, generate new ideas, support and share best practice, and form new cross-discipline collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | InFocus article (Jennifer Simpson) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | InFocus review article for EM-UK meeting (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guildford |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at Innovate Guildford science festival. Visitors to stand able to discuss issues related to animal diseases and their control (with a particular focus on influenza and on use of genetic modification technologies) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guilford |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Broadbent gave a talk at 'Innovate Guilford' Festival outlining the work we are doing with Avian Virus Vaccines, including those against IBDV. The aim was to raise public awareness on different avian viruses, and genetically modified vaccines. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Insect Festival 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies). |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/ |
| Description | Invitation to give keynote talk on 'Control of avian diseases: Challenges and opportunities' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave the Keynote talk on 'Control of avian diseases: Challenges and opportunities' at this International Symposium organized with an aim to gather international virology experts from both human and veterinary fields to share research experience, update findings and contribute their expertise through presentation and interactive discussion. The topics will cover a wide range of virology research common in both human and animal aspects. In addition, technological platforms such as vaccine development, and novel assays will be emphasized and addressed. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.biotec.or.th/virus-symposium2018/index.php |
| Description | Invited Seminar University College London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at UCL to describe my ongoing research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited participant, Improving the Use of Evidence in Policymaking in the UK Government (Parliamentary Office of Science and Technology) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited to attend meeting to launch POST report "Improving the Use of Evidence in Policymaking in the UK Government" as a result of previous collaboration. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.sciencecampaign.org.uk/resource/casereportimprovingtheuseofevidence2017.html |
| Description | Invited seminar at UC Riverside 05/05/2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at University of California, Riverside |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited seminar at the National Health Research Institutes, Taiwan. 27 Feb 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation describing research in my group on mosquito developmental biology and its potential uses for mosquito control; attended by primarily by members of the National Mosquito-Borne Diseases Control Research Center. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at the University of Nottingham seminar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited seminar entitled: "Arbovirus encephalitis: from tissue culture, to mosquitoes to mice" was delivered. Discussions for potential collaborations followed. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited seminar in Public Health England- Porton Down |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar entitled: "Innate immune responses and pathogenesis of alphavirus infections". Numerous questions were asked and requests for collaborations were made. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at 9th Neuroinfections Conference, Bialowieza - Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited presentation entitled: "Using small RNAs to fight encephalitic arboviruses" was delivered. The presentation generated a lot of interest and questions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at 9th Neuroinfections Conference, Bialowieza - Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited talk entitled: "Using small RNAs to fight encephalitic arboviruses" was delivered. Numerous questions were asked. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at South Wilts Virus Group (SWVG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled: "The role of small RNAs in arbovirus infections". Multiple questions were asked and potential for collaborations was identified. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at a workshop on arboviruses and their vectors in University of Malaya - Malaysia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled: " The role of small RNAs in arbovirus infections" was delivered. Multiple questions and requests for collaborations followed the presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited to talk at the International Conference on Building Human and Animal Health Capacities organised by the Jordan University of Science and Technology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated in the discussion and talked on 'The recent advances in vaccination-based control of poultry diseases'. The need for increased awareness of the pathogen diversity in the design of vaccines and the opportunities from advances in vaccine technologies were discussed |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.just.edu.jo/conferences/bhahc/Pages/default.aspx |
| Description | Keynote talk at the World Veterinary Poultry Association meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give the keynote talk on 'Avian tumour viruses: their contribution to our understanding of cancer' at the World Veterinary Poultry Association XXth Congress in Edinburgh |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.wvpac2017.com/ |
| Description | Lecture given to University of Surrey MSc Veterinary Microbiology students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lecture of dynamics of vector-borne diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at Univerity of Cambridge |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012 |
| Description | Lecture on dynamics of infectious diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture as part of MSc in Veterinary Microbiology at University of Surrey |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016 |
| Description | MMC2017 Learning Zone seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented a seminar on preparation of samples for electron microscopy to 24 MMC2017 delegates. Questions followed asking for advice on specific examples, also advice on interpretation of data and how to improve results. |
| Year(s) Of Engagement Activity | 2012,2015,2017 |
| Description | MSc student visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I hosted ten MSc students from University of Surrey, discussed avian research with them and demonstrated some laboratory techniques. The students gained an understanding of academic research and laboratory work. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Malaysia workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organised and participated in workshop on genetic control of mosquitoes, primarily focusing on refractory methods. Included a set of open lectures from international speakers at University of Malaysia and more focus workshop-style meetings. Several reported changes to research activities and also opinions, also follow-up meeting organized in Glasgow later in 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Medical and Veterinary Virus Research Symposium (MVVR) Kenya |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at international conference on One Health research in Kenya |
| Year(s) Of Engagement Activity | 2017 |
| Description | Microbiology Today article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Networking presentation-INRA, Paris, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation at INRA describing the role of the SH protein of BRSV in modulating immune responses in calves. This presentation resulted in a heated debate on the role of viral proteins in immune evasion and their activities in attenuated vaccines. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Nick Rufford, Sunday Time Mag, published 27/08/2017 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided information and quotes for Sunday TImes Magazine article on GM mosquitoes and Zika |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.thetimes.co.uk/article/how-genetically-engineered-mosquitoes-will-save-lives-kwc8nmwh5 |
| Description | Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I presented my work at the Nidovirus Symposium, which is held every three years and brings together researchers from industry and academia from many different countries. I had some interesting discussions with other researchers and built my network. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Oral presentation at the Microbiology Society annual meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An oral presentation on Inhibition of Semliki Forest Virus Replication Through Disruption of Lipid Homeostasis was delivered. The audience showed high interest and a good discussion and exchange of ideas followed the presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Oral presentation to Large Animal Research Network 24th May 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Talk about work understanding PB1-F2 function in avian hosts highlighting how the animal work carried out was undertaken and monitored. this was delivered to an audience of researchers, funders and industry interested in animal model systems for research and the 3Rs commitment surrounding this work. Discussions with interested parties about our chicken work at the Institute and the diverse way that the birds are entertained whilst being housed (e.g. live food, vegetables, perches, dust baths etc). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Organisation of UK-India Bioinformatics Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The meeting discussed the challenges and opportunities and have decided to come up with a strategy document on working together between UK and India on data-driven biology |
| Year(s) Of Engagement Activity | 2018 |
| Description | Organised the 3rd UK-China CERAD meeting in Guildford, UK in July 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The 3rd UK-China CERAD meeting helped to bring together professional from both countries to identify challenges and exploit the opportunities for improved control of poultry diseases and increasing food security. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uk-china-cerad.org/ |
| Description | Organising and giving Keynote talk at the GARAD meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Global Alliance of Poultry industry professional and academia to discuss about the advances in control strategies of diseases |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://Garad.org |
| Description | Outreach at TeenTech Events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | TeenTech runs lively initiatives with a supporting Award scheme to help young teenagers see the wide range of career possibilities in Science, Engineering and Technology. They work collaboratively with companies, Universities, business organisations and education business partnerships to build sustainable and imaginative programmes focussing on regions of greater social need in the UK and Europe. This outreach actvity involved primarily school children aged 12/13. Several hundred attended and our attendees (Laura Tugwell) spoke with about 30-40 children/teachers. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.teentech.com/ |
| Description | Oxford DTP students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Participant in IDEAS arboviruses workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018). |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://ideas.princeton.edu/workshop-for-2017/ |
| Description | Participation in student day at the Pirbright Institute |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Student open day was participated by postgraduate students registered at several Universities, and scientists from Pirbright institute. Students were given a chance to discuss their research activities and future plans with senior scientists. Due to high interest from the students, the institute has decided to organize another open day. |
| Year(s) Of Engagement Activity | 2016 |
| Description | PhD course in Electron Microscopy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Intensive workshop containing lectures and practicals in the use of electron microscopy in life sciences. This takes place every year at the University of Copenhagen, I am a course organizer and invited speaker. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016 |
| Description | Pirbright Pride day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Set up a stand at the described our research, engaged with policymakers, industry and participants from other organizations and distributed leaflets. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Population Biology of Vector-Borne Diseases Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Poster presentation in the IMAV focused meeting on Arboviruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A poster on Inhibition of Semliki Forest Virus Replication Through Disruption of Lipid Homeostasis was presented at the IMAV meeting. The poster generated a lot of discussion and interest. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Poultry Health course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry Health Course is run as a residential and online course to transfer recent advances in avian disease research from the laboratory to the field. |
| Year(s) Of Engagement Activity | Pre-2006 |
| URL | http://www.poultryhealthcourse.com/ |
| Description | Practical training given to LSHTM MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Two-hour practical teaching session given to 12 MSc students at the London School of Hygiene and Tropical Medicine (LSHTM) on 17th November 2017 (Lara Harrup). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation and sicussion with members of the CLA group visiting Pirbright Institute |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a visit to the Pirbrigtht Institute and I presented on Bluetongue virus epidemiology, transmission and risk to the UK agriculture followed by a general discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at Global Alliance for Research on Avian Diseases Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of my research at the Global Alliance for Research on Avian Diseases Conference in Vietnam to approximately 80 conference participants resulted in discussions about future research directions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at RIVR meetings |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of my research at Recently Independent Virology Researchers (RIVR) meetings in 2016, 2017 and 2018. I discussed my work and future collaborations with other virology researchers working in the UK. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | Presentation at the Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Cheltenham Science Festival is one of the UK's leading science festivals. Founded in 2002, the Cheltenham Science Festival has united some of the greatest scientists, writers and thinkers to explore the wonders of the natural world, the complexities of the human mind and the mysteries of science and space. It was an opportunity for inquisitive minds of all ages to find out more about the world of science. The audience included Key Stage 1-3 students on the start of their education which in turn could lead to future careers in science. The main purpose was to engage with various stakeholders from different backgrounds to inform and educate the general public on BBSRC-funded science which is carried out at the Pirbright Institute. During the talk I was able to demonstrate that basic science can have practical implications. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cheltenhamfestivals.com/science |
| Description | Presentation by ND at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The post-doctoral researcher presented our data at the 14th international Nidovirus symposium. She discussed data and potential collaboration with other scientisits from the field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation by RH at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | PhD student presented our data at the 14th international Nidovirus symposium. He discussed results and potential for future collaboration with other scientists in the field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation: BSI AGM: Immune regulation by the SH protein of BRSV |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the BSI's AGM to describe the data generated regarding the role of the SH protein of BRSV in regulating immune responses after natural infections. Initiated a debate about the role of the SH protein of human RSV in immune regulation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Princess Anne opening Jenner |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Princess Anne, entourage, local politicians and dignitaries visited to open new research building. I was one of small number asked to present/demonstrate/describe our research work, which is on genetic modification of mosquitoes to provide new tools with which to help control mosquito-borne viral diseases. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public Health Entomology Group (LSHTM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture on 4th April 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public engagement organized at Oxford |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Set up a stand at the event, a museum at Oxford, and discussed and described research activities within the Institute with public. Set up demonstrations from some biological specimens and distributed leaflets and questionnaire. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Reddit AMA (Ask Me Anything) on vector-borne diseases |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/ |
| Description | Reverse genetics seminar to MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A seminar was presented describing reverse genetics of viruses, including infectious bronchitis virus and the application of reverse genetics in research. The students were interested and engaged, participating in activities and asking questions. We were invited to present the seminar in subsequent years for new student intakes. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016,2018 |
| Description | Royal Society of Biology Biology week talk, Winchester, 10/10/2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk organized by Royal Society of Biology as part of Biology Week. This one in Winchester, audience was general public with strong representation of school-age. Questions and discussion during and after formal talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | SGM Meeting 2017 Presentation: Regulation of the transcription factor NF=kB by the SH protein of BRSV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at a workshop of the Society for General Microbiology on the role of the SH protein of BRSV in regulating the transcription factor NF-kB in bovine antigen presenting cells. Many questions about protein-protein interactions were generated. Good feedback on our work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Scheduled Twitter session with University of Nottingham students on professional skills for biosciences |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://twitter.com/search?q=%23biosciprofskills |
| Description | School visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed different aspects of scientists' work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Met and discussed A level students in small groups (3 students at the time) and discussed different aspects of my work as a scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Scientific Presentation: SOVE lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Society of Vector Ecology Presentation 'The Gnatwork'. 6th October 2017 over 150 attendance. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uibcongres.org/sove2017/ |
| Description | Site tour with Department of Trade and Industry |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Tour/site visit with Department of Trade and Industry (25 people attending) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Site tour with UK Science Partnership for Animal and Plant Health, BBSRC (Chris Jacobs, Julie Fitzpatrick) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 'Fact-finding' visit from Chris Jacobs (Head of Secretariat, UK Science Partnership for Animal and Plant Health) & Julie Fitzpatrick (Chair of the Partnership) to organisations involved in the areas of animal and plant health science capabilities, to gain a better understanding of who the key players are, what they're working on, and any particular issues the Partnership may be able to address. |
| Year(s) Of Engagement Activity | 2017 |
| Description | St Andrew's Catholic School visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | College students visited the Institute to learn about lab designs. They were given talks about the equipment and labs and then toured around the labs at Pirbright. Students were highly interested about our facilities and the work we are conducting at The Institute. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Surrey County Show (Guildford) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stall at Surrey County show attended by Jo Stoner (Research Technician). Gave commentary on the threat of viruses to UK livestock species. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://surreycountyshow.co.uk/ |
| Description | Surrey Open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Described the research activity of the Pirbright Institute for students from school, graduate and postgraduate students, and provided information on research facilities in the institute. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.surrey.ac.uk/opendays/vet |
| Description | Talk at the Merseyside BSI Affinity group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | I described the methods we used to identifyTissue resident memory cells in pigs, which sparked a lively discussion and interest in the technique. As a result I have established two collaborations with colleagues from Liverpool. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk to Agrifood and Biosciences Institute, Northern Ireland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Formal presentation on Culicoides-borne arboviruses with discussion of impact in Northern Ireland |
| Year(s) Of Engagement Activity | 2017 |
| Description | Teaching- lecturing, small group classroom teaching and laboratory practical teaching |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | I have been actively engaged with teaching activities at the University of Surrey, giving lectures, small group classes and laboratory practical classes to vet students and MSc students. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| Description | Toolbox workshop at IVVN Stirling 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A second workshop held as a sattelite meeting to the International Veterinary Vaccinology Conference in Stirling to decide on community priorities for future immunological tools to promote veterinary vaccine development. |
| Year(s) Of Engagement Activity | 2012,2018 |
| Description | Tour of Philip Mellor Insectary (BBSRC) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | BBSRC tour of Philip Mellor Insectary on 4th December 2017 (Jo Stoner). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Tour of Philip Mellor Insectary (Country Land and Business Association) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Tour of Philip Mellor Insectary with Country Land and Business Association (20 people) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Tour of Pirbright Research facilities for CLA group |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a tour of the Jenner building facilities at The Pirbright Institute. I led a tour of our building for the group and described the work undertaken by the avian research programme here. |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of California Davis School of Veterinary Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | External Meeting at University of California Davis School of Veterinary Medicine, 16-18th October 2017. Talk given (Lara Harrup) on 'Tools and Resources for Arbovirus Epidemiology in the Genomic Era'. Meeting organised as part of the University of Liverpool BBSRC US Partnering Award: Vector-borne diseases in the UK & US: common threats and shared solutions (BB/N021916/1). |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Surrey Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I represented The Pirbright Institute at the University of Surrey Vet School open day, talking about my research and what it is like to be a research scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | VetVac toolbox kick off meeting, Pirbright |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Organsised a workshop part sponsored by the BBSRC Veterinary Vaccinology Network that bought key international leaders in veterinary immune reagents together to discuss lessons from the past and how we should progress in the future, reaching as wide an audience as possible. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Veterinary Research Club |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of the data generated and its importance in understanding immune responses to vaccination and natural infections. About 50 veterinarians and researchers working in veterinary sciences attended the one-day meeting, which initiated discussions about the possibility of generating new vaccines against BRSV. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Virtual video tour of the animal facilities in Pirbright |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Contributed to public understanding of animal research by being interviewed on the virtual video tour of the animal facilities in Pirbright - one of only four such initiatives in the UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Volunteered at a school open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I represented The Pirbright Institute talking at a school about my research and what it is like to be a research scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | a talk at the Recently Independent Virology Investigators meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talks outlining my current research and future plans. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| Description | organised workshops at Microbiology Society annual conferences 2014 - 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I co-organised virology division workshops on viral evolution and diversity and RNA viruses with colleagues from the virology division. The workshops were held at the annual Microbiology Society conferences in spring each year. Organisation involved selecting abstracts for oral or poster presentation, ordering the presentations and chairing the sessions. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
| Description | talk to the U3A |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a talk to the University of the 3rd Age (U3A)- a group of the general public above the age of 65. |
| Year(s) Of Engagement Activity | 2016 |