Low Containment

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

Low containment experimental facilities support, enhance and extend the range of viruses studied at the Pirbright Institute. The primary infrastructure associated with these facilities is the BBSRC National Centre for Vaccinology, the Jenner Building, which was opened in 2016. This facility houses a wide range of groups working on strategically important endemic and exotic viral pathogens that can be handled under low containment, including Marek’s disease virus, infectious bronchitis virus and low pathogenicity animal influenzas. In addition, the Jenner building also houses groups that study the genetics and genomics of virus hosts, using state of the art technologies. This capability is nationally unique both because it supports studies of viruses not replicated elsewhere in the UK and because of its position in close proximity to High Containment Experimental Facilities in Pirbright.
Our in vivo facilities supporting avian research are housed in a temporary facility. This enables study of internationally important avian viruses within the natural host. During the term of the CCG, new facilities will be constructed on the Pirbright site, enabling expansion of this work. This includes a specified pathogen free (SPF) hatchery and rearing facility due for delivery in early 2018 and refurbishment of current high containment animal facilities to deliver a low containment Poultry Experimental Facility in late 2018.

Publications

10 25 50
 
Description The key development within low containment science at The Pirbright Institute is that of providing facilities that allow handling of non-infectious and low pathogenicity agents within laboratories that are safe for the user and environment and with minimal interruptions to work. Within the first year of reporting, these objectives have been achieved to the standards within the Impact Plan for this project in the following ways: 1) Interruptions to science are within the boundaries set for the facility. 2) Pirbright remains a hub for Avian research as demonstrated by the production of publications and outreach activities. The SPF facility construction project remains on time and on budget and is due to open in 2018. 3) Relationships with the National Avian Research Facility remain open and were reinforced by meetings at both sites. 4) Bioinformatics capabilities have been strengthened significantly with expansion of computing facilities and staff, the latter provisioned from the Science Services CCG component. This has resulted in the publication of a range of papers in this area within the reporting period. 5) Significant progress has been made in opening up the low containment facilities for training and also in provision of outreach activities. 6) Insectary facilities, which have seen a significant rise in demand within the science conducted by Pirbright have been expanded via refurbishment of the IS4L facility. This is a medium term solution and dedicated facilities will be required in the longer term.
Exploitation Route Building of the Avian SPF facility remains a major component of the Pirbright suite of buildings and will be a major focus of research in this field both for internal and external workers. In addition, the interim insectary facilities will enhance workers abilities to carry out research on exotic and in some cases transgenic arthropods which is key future demand for the site. Keeping pace with the health and safety and biosecurity concerns around these studies will also influence the wider community as evidenced by the close relationship with HSE on guidelines for arthropod containment.
Sectors Agriculture, Food and Drink

 
Description Minimal infrastructure downtime enabled by planned preventative maintenance on the BBSRC National Vaccinology Centre (Jenner Building) has enabled our research to be conducted under expected timescales and provided additional space for external workers. In addition, the provision of interim insectary facilities has provided a medium-term solution to a lack of space, without major disruption to work programmes, although a more permanent solution will be required in the long-term.
First Year Of Impact 2017
Sector Agriculture, Food and Drink
Impact Types Societal,Economic,Policy & public services

 
Description Chair of BSI Comparative Veterinary Immunology Group
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Human Infection Challenge Models for Vaccination
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Netherlands Commission on Genetic Modification (COGEM) Project "Gene drives, inventory of previous research and experience"
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
 
Description RCUK Engagement workshop, Cosener's House, 20-21 April 2017
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Training MSc students
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Delivered a new training session to MSc students teaching viral quantification assays. This lead to a greater understanding of laboratory techniques and academic research.
 
Description WHO R&D Blueprint Roadmaps: Consultation on Nipah virus
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Active and passive Immunity induced by aerosols
Amount £100,000 (GBP)
Funding ID BB/R506448/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 08/2021
 
Description BBSRC Newton Fund Swine and Poultry Research Initiative
Amount £865,623 (GBP)
Funding ID BB/R01275X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 06/2021
 
Description British Egg Marketing Board PhD studentship
Amount £76,000 (GBP)
Organisation British Egg Marketing Board 
Sector Private
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Development of novel universal influenza vaccines
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 10/2020
 
Description Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development
Amount £440,000 (GBP)
Funding ID BB/R007896/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description LVIF
Amount $1,500,000 (CAD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 04/2018 
End 09/2020
 
Description NC3Rs Research Project Grant
Amount £436,339 (GBP)
Funding ID NC/R001138/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
Country United Kingdom
Start 12/2017 
End 11/2019
 
Description Pathfinder BB/R012431/1 Grant holder: Dr Mark Fife. Grant title: chIFITM knockdown/knockout technology as a platform technology for increased vaccine yields in SPF Eggs.
Amount £12,500 (GBP)
Funding ID BB/R012431/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 02/2018
 
Description The impact of natural genetic variation on ruminant immune responses
Amount £80,000 (GBP)
Organisation University of Southampton 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description UK-China partnership on Global Food Security: Combating avian tumor diseases for sustainable poultry proudction
Amount £382,000 (GBP)
Funding ID BB/R007632/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2020
 
Title An ex vivo IBDV infection model using a chicken primary B cell culture system 
Description Recently, it has become possible to culture chicken primary B cells in vitro in the presence of a soluble construct of chicken CD40L that was made at The Pirbright Institute. We have demonstrated that these chicken primary B cells can be infected with infectious bursal disease virus (IBDV). This system will be validated and expanded to other B cell tropic viruses in order to replace the use of infected chickens in research, in an NC3Rs funded grant. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2017 
Provided To Others? Yes  
Impact Using this system, we have determined that chicken primary B cells respond to IBDV infection by inducing Type I IFN responses. However, the induction is more pronounced in cells infected with an attenuated strain compared to a very virulent strain. This is consistent with the very virulent strain down-regulating antiviral responses to a greater extent than other strains which may, in part, explain its enhanced virulence. We also observed a reduction in the expression of key genes involved in B cell proliferation and activation following IBDV infection which was only possible by using the primary B cell culture system. 
URL https://www.ncbi.nlm.nih.gov/pubmed/?term=broadbent+dulwich
 
Title CRISPR/Cas9-based gene editing of avian herpesvirus vectors to develop novel recombinant vaccines 
Description Development of recombinant herpesvirus vaccines are usually achieved by classical homologous recombination methods. The advent of new genome editing tools has enabled its application on avian herpesvirus vaccine strains to develop new recombinant vaccines potentially capable of expressing protective antigens from multiple pathogens 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The major impact will be in the generation of novel vaccines that can simultaneously protect against multiple avian diseases 
URL http://www.poultryworld.net/Health/Articles/2016/12/Is-GM-technology-the-future-of-poultry-vaccines-...
 
Title Developed an in vivo infection model to generate highly pathogenic bovine RSV for challenge studies. Developed an accompanying in vitro titration method to calculate yield of virus produced. 
Description Developed an in vivo infection model to generate highly pathogenic bovine RSV for challenge studies. Developed an accompanying in vitro titration method to calculate yield of virus produced. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Will help use and improve the calf challenge model of bovine RSV for vaccine testing. 
 
Title Development of tetramers to study immune responses in pigs 
Description The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume. It is also an important vector in the birds to human infection cycle. A major drawback of the current pig model is the inability to analyze antigen-specific CD8+ T-cell responses, which are critical to respiratory immunity. We addressed this knowledge gap using an established in-bred pig model with a high degree of genetic identity between individuals, including the MHC (Swine Leukocyte Antigen (SLA)) locus. We developed a toolset that included long-term in vitro pig T-cell culture and cloning and identification of novel immunodominant influenza-derived T-cell epitopes. We also generated structures of the two SLA class I molecules found in these animals presenting the immunodominant epitopes. These structures allowed definition of the primary anchor points for epitopes in the SLA binding groove and established SLA binding motifs that were used to successfully predict other influenza-derived peptide sequences capable of stimulating T-cells. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Peptide-SLA tetramers were constructed and used to track influenza-specific T-cells ex vivo in blood, the lungs and draining lymph nodes. Aerosol immunization with attenuated single cycle influenza viruses (S-FLU) induced large numbers of CD8+ T-cells specific for conserved NP peptides in the respiratory tract. Collectively, these data substantially increase the utility of pigs as an effective model for studying protective local cellular immunity against respiratory pathogens. 
 
Title Established a method to immortalize bovine antigen presenting cells 
Description Established protocols to prepare lentiviruses expressing the proto-oncogenes Bmi1 and hTERT. Established protocols to transduce and generate immortal bovine antigen presenting cells derived from peripheral blood monocytes. 
Type Of Material Cell line 
Provided To Others? No  
Impact This is the first successful attempt at generating bovine immortal monocytic cell lines. This method can also be applied to immortalize B cells. This will result in reducing the number of animals used in experimentation and considerably reduce costs. 
 
Title Established human T cell lines expressing bovine WC1 genes for the analysis of WC1 signal transduction pathways. 
Description Established human Jurkat T cells expressing bovine the bovine gammadelta WC1 co-receptor 
Type Of Material Cell line 
Provided To Others? No  
Impact This cell line will help determine the function of the WC1 co-receptor in gammadelta T cell activation and function. 
 
Title Generated a MHC-defined bovine monophagocytic cell line. 
Description Using the method described above, successfully generated one MHC-defined bovine monophagocytic cell line (A18) which expresses and single classical MHC gene (HD6). 
Type Of Material Cell line 
Provided To Others? No  
Impact Will help reduce the number of animals used in experimentation. Will help resolve antigen presentation pathways in bovine cells and using bovine pathogens. Will help understand T cell activation pathways using MHC matched and mis-matched cells. Will help investigate bovine NK cell activation. 
 
Title Generated monophagocytic reporter cell lines to study the NF-kB signaling pathway 
Description Generated human monophagocytic cells expressing alkaline phosphatase reporter gene under a NF-kB promoter sequence. 
Type Of Material Cell line 
Provided To Others? No  
Impact This cell line is helping determine the role of RSV genes in immune modulation of monophagocytic cells in response to RSV infection. 
 
Title IBDV Reverse Genetics System 
Description We have developed a reverse genetics system for IBDV. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact We have used the reverse genetics system to generate recombinant IBDVs and chimeric recombinant IBDVs that contain genes from classical and very virulent strains of IBDV in the background of a cell culture adapted attenuated strain. This will enable us to study the effect of individual virus genes on pathogenicity. 
 
Title Optimisation of chicken kidney cell culture preparation 
Description We have optimised the method of extracting kidneys and preparing chicken kidney (CK) cell cultures from chickens. CK cells are used for in vitro assays to study avian viruses, in particular infectious bronchitis virus. 
Type Of Material Cell line 
Year Produced 2017 
Provided To Others? No  
Impact This has increased the yield of viable cells and the quality of the cell cultures. We can now obtain the number of cells we require using fewer chicken kidneys, therefore requiring fewer chickens to be culled. This is an important development for the 3Rs. We hope to publish this method for others' information. 
 
Title Stable chicken cell lines overexpressing chicken IFITM1,2 and 3 
Description In collaboration with Mark Fife, we have produced chicken stable cell lines overexpressing chicken IFITM1,2, 3 and a mutant chicken IFITM3 lacking palmitoylation sites. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact These cell lines will be used to evaluate the effect of the IFITM proteins on the replication of different viruses, including IBDV. 
 
Title method for identification of lung Tissue resident memory cells in pigs 
Description Recent overwhelming evidence indicates the importance of local tissue-resident memory T cells (TRM) in protective immunity. Most work on TRM has been performed in mice and the TRM defined as inaccessible to intravenously administered anti-T cell antibody. However there are very few data on TRM in large animals. For the first time we have defined TRM in the pig influenza model. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact The identification of TRM and their robust protective capacity in site-specific infection has provided a new paradigm by which to assess T cell-mediated responses and an important new target for vaccine design. Since swine are an economically important species, are used as a large animal model for human infection and play a key role in the emergence of novel and potentially zoonotic influenza viruses, the identification of TRM in pigs will allow us to study their role in immunity to swine influenza.and how best to induce them by immunisation. 
 
Title replication competent recombinant split-GFP infectious bursal disease virus 
Description We have generated a replication competent recombinant split-GFP infectious bursal disease virus (IBDV) where a small GFP11 molecule is tagged to the virus polymerase (VP1) to make IBDV-VP1-GFP11. Infected cells that express the GFP1-10 molecule fluoresce green when the GFP11 tag complements the GFP1-10. The IBDV-VP1-GFP11 colocalises with VP3 and dsRNA and therefore is likely to be present at the sites of virus replication. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact This tool can be used to study IBDV replication complex development in infected cells. 
 
Title E-MTAB-5947- Transcription profiling by array of differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV) 
Description Microarray data submitted to ArrayExpress from chicken primary B cells infected with a very virulent and attenuated strain of IBDV. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact This is the first ever microarray data of chicken primary B cells infected with IBDV and will be of use to other researchers in the area of B cell biology or IBDV virology 
URL https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-5947/
 
Description Aerosol delivery of vaccines and therapeutics 
Organisation Aerogen
Country Ireland 
Sector Private 
PI Contribution Developed the pig influenza model which is a natural host pathogen system
Collaborator Contribution Provided expertise and equipment for aerosol delivery
Impact Successfully delivered vaccines by aerosol
Start Year 2015
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of California, Davis
Department UC Davis College of Biological Sciences
Country United States 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description Bridget Penman 
Organisation University of Warwick
Department School of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We are providing genetic data and diversity measures of MHC and associated receptors to inform the modelling efforts to elucidate which selection pressures are the main drivers for the types of diversity we see in extant species.
Collaborator Contribution They are experts in mathmatical modelling and will provide data to help explain genetic diversity in cattle.
Impact Not yet
Start Year 2017
 
Description Derek Bickhart-USDA 
Organisation U.S. Department of Agriculture USDA
Department Beltsville Agricultural Research Center
Country United States 
Sector Academic/University 
PI Contribution Our group has provided the genomic framework of the cattle NK cell regions and the biological input.
Collaborator Contribution The ARS group has used our data as a framework to map and predict cattle SNPs for variable immune traits using their whole genome data
Impact Research application based on preliminary data to a BBSRC-NIFA call. This collaboration is multi-disciplinary combining molecular biology and computational biology
Start Year 2014
 
Description Development of tetramers in the Babraham pig model 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed the aerosol delivery method of vaccine and provided material (spleen, BAL and blood) from inbred animals (Babraham pigs) following immunisation with the candidate universal vaccine, S-FLU.
Collaborator Contribution Developed porcine influenza specific class I tetramers and provided the epitope map of Babrahams S-Flu responses to NP, M1, M2, PB1 and PB2 that could be presented by SLA-1 or SLA-2 Grew pig T cell clones for the first time in 30 years.
Impact Multidisciplinary - immunology, virology, protein chemistry. Paper not yet published
Start Year 2014
 
Description Dr Michael Skinner, Imperial College London 
Organisation Imperial College London
Department Department of Primary Care and Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We aim to compare the host transcriptional response of primary chicken B cells infected with different strains of IBDV of varying virulence. We have the specialist reagents and expertise in house that are required to culture primary chicken B cells, and we have access to different strains of IBDV.
Collaborator Contribution Dr Michael Skinner and his team at Imperial College London have the expertise and facilities to generate and analyse RNA-Seq data in order to determine host transcriptional responses. This is required in order to complete the aim of the project.
Impact Further funding: PhD studentship (£102,800) - Dr Andrew Broadbent at The Pirbright Institute and Dr Michael Skinner at Imperial College London are joint supervisors for a PhD student working on this project. Further Funding: Houghton Trust (£8,000)- Dr Andrew Broadbent was awarded a Houghton Trust Small Research Grant to contribute to this project.
Start Year 2014
 
Description Efficacy of a candidate universal influenza vaccine, S-FLU. 
Organisation University of Oxford
Department Radcliffe Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Tested the immunogenicity and efficacy of a candidate universal influenza vaccine, S-FLU, in pigs. For the first time we demonstrated that S-FLU when administered by aerosol can reduce viral load in nasal swabs and lung in pigs after influenza virus challenge. We have shown that the most efficient way to administer this vaccine is by aerosol.
Collaborator Contribution Professor Alain Townsend has developed the S-FLU vaccine.
Impact The most efficient way to induce immune response in the lung is after aerosol delivery of LAIV vaccines in pigs. The most efficient way to induce cross-protective immunity is by aerosol delivery of S-FLU to the lungs of pigs
Start Year 2014
 
Description Engineering mosquitoes for reduced vector competence for chikungunya virus 
Organisation University of Malaya
Department Department of Medical Microbiology
PI Contribution Developed joint research programme, led successful application for funding, coordinate programme.
Collaborator Contribution Various specific strands of research, and group discussions about results, conclusions, research progress and future activities.
Impact reported under funding
Start Year 2016
 
Description Engineering mosquitoes for reduced vector competence for chikungunya virus 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution Developed joint research programme, led successful application for funding, coordinate programme.
Collaborator Contribution Various specific strands of research, and group discussions about results, conclusions, research progress and future activities.
Impact reported under funding
Start Year 2016
 
Description Engineering mosquitoes for reduced vector competence for chikungunya virus 
Organisation University of Tartu
Department Institute of Technology
PI Contribution Developed joint research programme, led successful application for funding, coordinate programme.
Collaborator Contribution Various specific strands of research, and group discussions about results, conclusions, research progress and future activities.
Impact reported under funding
Start Year 2016
 
Description Generation of immortalised bovine antigen presenting cells 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Using a lentivirus vector expressing proto-oncogenic genes, we generated MHC-defined immortal bovine antigen presenting cells that can be used in antigen presentation studies or virus-host interaction studies in the future.
Collaborator Contribution The University of Surrey provided several lenvirus vectors and preparation for immortalization studies.
Impact A publication in progress titled "Generation of immortal bovine antigen presenting cells" and the generation of a library of MHC-defined bovine cell lines.
Start Year 2017
 
Description Horizon Discovery Ltd Cambridge Research Park, United Kingdom 
Organisation Horizon Discovery Group plc
PI Contribution Verify IFITM knock-out cell by qPCR and immuno-blotting. Verification of further knock-out cell lines by DNA sequencing, immuno-blotting and qPCR Cell infection with Avian Influenza Viruses Assess the viral titre of cells infected with Influenza Viruses in K/O and wildtype cells. Quantitative analysis of viral infection in IFITM K/O cells Demonstrate increased AIV viral titres at lab scale and estimation of what this may equate to with respect to vaccine dose yields. Analysis of IFITM K/O cell lines permissivity to a range of additional animal viruses (Relevant to the LVIF). Milestone 7: Demonstrate permissivity increased and viral titres for a range of LVIF relevant viruses in the edited cell lines.
Collaborator Contribution Develop a CRISPR/cas9 gene editing system to specifically target the chIFITM locus in avian cell culture
Impact Grant funding
Start Year 2017
 
Description ILRI Research Collaboration (Kenya, March 2017) 
Organisation International Livestock Research Institute (ILRI)
Country Kenya 
Sector Charity/Non Profit 
PI Contribution Exchange of ideas and samples for indigenous breeds of livestock
Collaborator Contribution Contributed samples for analysis.
Impact Analysis of indigenous breed genomic sequences for Immune function genes.
Start Year 2017
 
Description Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Collaborator Contribution My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Impact Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017.
Start Year 2017
 
Description Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. 
Organisation University of Kent
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Collaborator Contribution My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Impact Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017.
Start Year 2017
 
Description Identification of human orthologues of bovine Workshop Cluster 1 genes 
Organisation University of Oxford
Department Nuffield Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution The Workshop Cluster 1 (WC1) gene family encodes a group of proteins thought to be involved in immune recognition. These genes are exclusively expressed on T cells expressing the gamma and delta T cell receptor and are well characterized in the bovine system. We have began investigating the presence and expression of WC1 on human cells using co-immunoprecipitation and mass spectrometry analysis of putatitve human WC1 genes.
Collaborator Contribution The Univ. of Oxford has developed a pipeline to identify protein fragments using mass spectrometry and bioinformatics from putative proteins from which little or no information is currently known. This pipeline has been applied to identify putative human WC1 proteins obtained from co-immunoprecipitation/mass spectrometry studies.
Impact The identification of one human WC1 gene/protein. A publication in progress titled "Identification of the human orthologue of a Workshop Cluster 1 gene expressed on gammadelta T cells"
Start Year 2017
 
Description Imperial 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint supervision of PhD student
Collaborator Contribution Joint supervision of PhD student
Impact One successful completed PhD student. Papers published or in preparation. Another PhD student in progress.
Start Year 2010
 
Description Investigating the role of the SH protein of RSV in the duration of immunity 
Organisation Imperial College London
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided initial data supporting the hypothesis that the small hydrophobic protein of bovine respiratory syncytial virus regulates the host's immune response by modulating the transcription factors NF-kB and STAT1 in bovine cells
Collaborator Contribution Based on our results, Imperial has began investigating the role of the small hydrophobic protein of human respiratory syncytial virus on human cells.
Impact Publication in progress titled "Regulation of the B cell activating factor BAFF by the small hydrophobic protein of respiratory syncytial virus".
Start Year 2017
 
Description Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 
Organisation Chinese Academy of Agricultural Sciences
Department Shanghai Veterinary Research Institute
PI Contribution Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector
Collaborator Contribution Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/).
Impact organised joint meeting in China and the UK to discuss on challenges and opportunities
Start Year 2017
 
Description JN - Preparation of capped mesoporpus silica nanoparticles 
Organisation Polytechnic University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments
Collaborator Contribution Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments.
Impact Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples
Start Year 2016
 
Description JS - Production of monoclonal antibodies that recognise FMDV VP4 from mouse spleens 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution VLPs displaying the N-terminal 15 amino acids of FMDV were designed and produced at The Pirbright Institute and then mice were immunised with them. The spleens of the immunised mice were harvested and splenocytes stored. The response to the VP4 sequence was checked by ELISA and the mouse with the best response was selected to send the splenocytes for monoclonal production.
Collaborator Contribution The collaborators took the splenocytes obtained from the mouse experiments and carried out the fusions. They then screened the supernatants for positive wells that detected the VP4 sequence.
Impact Positive wells have been identified indicating some monoclonals that are specific for VP4 have been generated. These will be further screened for ability to recognise virus and to neutralise infection.
Start Year 2017
 
Description Leeds FBS 
Organisation University of Leeds
Department Leeds Institute of Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution Research and student supervision
Impact Research
Start Year 2009
 
Description Mosquito Interest Group 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques.
Collaborator Contribution Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques.
Impact Exchange of practical techniques, for instance in tracking oviposition of individual mosquitoes. Brainstorming for projects and papers, resulting in a GCRF VBD network proposal (which passed the first review but was not funded in the second) and an informal collaboration (which was intended for submission to UK-Thai call in 2017 but Thai partner was not eligible). Exchanges of colony strains of insects planned this month.
Start Year 2016
 
Description Mucosally Associated Invariant T cells (MAIT) in pig influenza model 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Identified MAIT cells in pig Influenza model. Provide samples from infected and immunised protected animals
Collaborator Contribution Provide expertise in characterising MAIT: development of tetramer; Zell scanner technology allowing high resolution studies of cell phenotype and functions
Impact Joint PhD studentship with Paul Klenerman, University of Oxford
Start Year 2016
 
Description Nicolas Locker - Investigation of translation regulation by infectious bronchitis virus 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution My team provide experience in molecular virology and cellular interactions of infectious bronchitis virus including previous experience of IBV accessory proteins regulating cellular translation. A PhD student works jointly between our labs.
Collaborator Contribution Dr Locker's team provide expertise in viral regulation of cellular translation and stress granule signalling. Dr Locker is also providing protocols, advice and training for techniques including ribopuromycylation and ribosome profiling. A PhD studentworks jointly between our labs.
Impact PhD student funding (studentship commenced Oct 2017) - Control of host cell translation by infectious bronchitis virus
Start Year 2016
 
Description Oxford 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on virus structural biology and joint PhD studentship
Collaborator Contribution Collaboration on virus structural biology and joint PhD studentship
Impact Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging
Start Year 2008
 
Description Oxford University Collaborations 
Organisation University of Oxford
Department Big Data Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific discussion, collaboration and manuscript preparation
Collaborator Contribution Scientific discussion, collaboration and manuscript preparation
Impact Manuscript in preparation
Start Year 2017
 
Description Parham Lab at Stanford 
Organisation Stanford University
Department School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Our group designed the experiments and generated a majority of the data. We also led the analysis of the data and writing of the manuscripts
Collaborator Contribution The Parham lab is the leading group worldwide in the evolutionary study of NK cell receptors and MHC class I. This group generated part of the data and helped in the analysis, interpretation and manuscript preparation
Impact Definition of the Cattle Killer Cell Igndash like Receptor Gene Family: Comparison with Aurochs and Human Counterparts Nicholas D. Sanderson, Paul J. Norman, Lisbeth A. Guethlein, Shirley Ellis, Christina Williams, Matthew Breen, Steven D. E. Park, David A. Magee, Farbod Babrzadeh, Andrew Warry, Mick Watson, Daniel G. Bradley, David E. MacHugh, Peter Parham, and John A. Hammond. Journal of Immunology, Dec 15, 2014; 193 (12) This collaboration is not multi-didciplinary
Start Year 2009
 
Description Professor Sahyan Sharif, University of Guelph, Canada 
Organisation University of Guelph
Department Department of Pathobiology
Country Canada 
Sector Academic/University 
PI Contribution Collaboration between my team and Professor Sharif lead to new finding in Avian immunology, specifically in understanding the effects of nutrients on antigen presenting cells and T cells of chicken. We took the lead in studying the effects of some nutrients (Vitamin D) on the function of chicken T cells, performed most of the experiments in our laboratory. Meanwhile, we participated in studying the effects of Vitamin D on antigen presenting cells of chicken by performing some key experiments because we had access to some specific reagents (monoclonal antibodies) recognizing molecules expressed on chicken antigen presenting cells.
Collaborator Contribution Professor Sharif team took the lead in studying the effects of Vitamin D on antigen presenting cells of chicken, and contributed to experimental plan for studying the effects on chicken T cells.
Impact Two publications in 2015 and 2016: 1. Nitish Boodhoo, Shayan Sharif, Shahriar Behboudi. 1a,25(OH)2 Vitamin D3 Modulates Avian T Lymphocyte Functions without Inducing CTL Unresponsiveness. PLoS One. 2016 Feb 24;11(2):e0150134 2. Bahram Shojadoost, Shahriar Behboudi, Villanueva AI, Jennifer Brisbin, Ali Ashkar, Shayan Sharif. Vitamin D3 modulates the function of chicken macrophages. Res. Vet. Sci. 2015 June, 100: 45-51
Start Year 2014
 
Description Research Collaboration with Nigeria (23rd - 28th January 2017) 
Organisation University of Nigeria
Country Nigeria 
Sector Academic/University 
PI Contribution Analysis of rare breed indigenous chicken in Nigeria.
Collaborator Contribution Helped with sampling and background information of the breed.
Impact Analysis is ongoing.
Start Year 2017
 
Description Swine haplotyping 
Organisation Gift Of Life
PI Contribution Prepared and shipped samples
Collaborator Contribution Sample analysis
Impact Data generation. Not multi-disciplinary
Start Year 2016
 
Description The Roslin Institute 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We have been working with several groups using our molecular and genetic data to help understand cattle cellular immunology. We have also hosted a visiting scientist to provide training in molecular techniques and data analysis, This has continued and now includes members of the Centre for Tropical Livestock Health and Genetics where we are engaged in sample sharing and maximising the value of genetic data by linking different sources as much as possible.
Collaborator Contribution Our partners have provided data and reagents as well as intellectual input to help us translate genetic diversity into functional diversity
Impact This collaboration is multi-disciplinary, although largely immunology and associated genetics is also involves bioinformatics
Start Year 2011
 
Description The effect of the microbiota on immunity to swine infleunza 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution We wish to establish the gut and nasal microbiome in normal healthy pigs and how this is affected by influenza infection. We have collected gut samples from pigs at different stages of infection, as well as nasal swabs which we will provide to our collaborators in Surrey.
Collaborator Contribution Our collaborators in Surrey will perform the sequencing and bioinformatics analysis to determine the microbial communities present in the samples.
Impact No outcomes yet - we are in the process of analysing the samples.
Start Year 2017
 
Description University of Glasgow collaborations 
Organisation University of Glasgow
Department MRC - University of Glasgow Centre for Virus Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Scientific discussion and reagent sharing contributing to grant applications and active research projects
Collaborator Contribution Scientific discussion and reagent sharing contributing to grant applications and active research projects
Impact Successful MRC grant application
Start Year 2015
 
Title Developed a "Vaccine PacMan" game on Scratch 
Description Developed a "Vaccine PacMan" game on Scratch to teach school children and the general public about long-term and short-term immunity work. Based on the classical PacMan game, Vaccine PacMan was designed to demonstrate duration of immunity when PacMan eats one of 4 defined "super pills". When PacMan eats a super pill, he becomes immune to the ghosts for a defined number of seconds. The four pills (vaccines) confer PacMan different lengths of immunity against the ghosts. The objective of the game is to find which pill gives the longest duration of immunity and use it to finish the game. This tool can be used to demonstrate the concepts of vaccination and duration of immunity. 
Type Of Technology Webtool/Application 
Year Produced 2016 
Impact Educational apps and electronic games have acquired a prominent role in teaching basic skills and concepts. When used as a complement to traditional methods of learning, these educational tools can improve children's classroom performance. It is often a challenge to make learning fun for children and sometimes traditional methods of learning aren't always engaging therefore it is important to try and capture their attention with creative tech-based methods of learning such as science games which can make learning more fun. Creating a PacMan-type game which is associated with such an iconic and popular game can engage children which in turn improves classroom performance, enhances technical skills and provides exposure to alternative methods of learning. 
 
Description 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities.
Year(s) Of Engagement Activity 2017
URL http://www.labanimaltour.org/pirbright
 
Description A talk at Surrey University 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Under- and postgraduate students attended a talk I gave at the Department of Biological Sciences in Surrey. There was a lively discussion afterwards and as a result I have established a new collaboration.
Year(s) Of Engagement Activity 2018
 
Description A talk at a symposium entitled: Using the 3Rs to support good science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I gave a talk at a Symposium held at The Pirbright Institute entitled: "Using the 3Rs to support good science". The talk was entitled: "A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry"
Year(s) Of Engagement Activity 2017
 
Description A talk at the British Poultry Diseases Group meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The Poultry Diseases Group meet quarterly and is comprised of representatives from private veterinary practices, vaccine and pharmaceutical industries, and the Animal and Plant Health Agency (APHA). I gave a talk at one of the meetings outlining my research to date and future directions.
Year(s) Of Engagement Activity 2017
 
Description Amy Lewis, The Scientist, 15/08/2017 re gene drive and Predator Free NZ 2050 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided information and quotes for article on potential use of gene drives as part of New Zealand effort to eradicate invasive predators
Year(s) Of Engagement Activity 2017
URL https://www.the-scientist.com/?articles.view/articleNo/50180/title/Driving-Down-Pests/
 
Description BBSRC website article: Halloween 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on BBSRC website: Halloween Creepy Crawlies
Year(s) Of Engagement Activity 2017
URL http://www.bbsrc.ac.uk/news/fundamental-bioscience/2017/171031-f-uk-creepiest-creepy-crawlies/
 
Description Biotech YES, Syngenta Jealott's Hill, 05 Oct 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Teams of postgraduate students from a number of universities and institutes attended talk as part of Biotech YES (Young Entrepreneurs' Scheme). Follow-up discussion influenced several aspects of their approach to entrepreneurship both within the competition and more generally
Year(s) Of Engagement Activity 2014,2015,2016,2017
 
Description CBD Open-ended online forum on synbio 06-10/2017 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact UN Convention on Biodiversity. Policy- discussion on synthetic biology: nominated participant in the Open Ended Online Forum on Synthetic biology as established in decision XII/24 of the Conference of the Parties to the Convention on Biological Diversity (COP) and extended in COP decision XIII/17 which ran from June to Oct 2017 (approx.)
Year(s) Of Engagement Activity 2017
URL http://bch.cbd.int/synbio/open-ended/discussion/
 
Description Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2017
 
Description Cafe Scientifique, Reading: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2007,2017
 
Description Caroline Seydel Genetic Literacy Project re GM mosquitoes/gene drive/Zika 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided background material and quotes for article on GM mosquitoes and control of Zika virus.
Year(s) Of Engagement Activity 2017
URL https://geneticliteracyproject.org/2018/01/29/waging-war-mosquito-split-gene-drive-hinder-spread-zik...
 
Description Centre of excellence for research on avian diseases (CERAD) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I was invited to present my work at the UK-China Centre of excellence for research on avian diseases (CERAD) meeting attended by researchers from UK, China and Thailand. There was lots of discussion about the research and future directions, including potential collaborations.
Year(s) Of Engagement Activity 2017
 
Description Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines. Presented at as PI of the ZELS project at ZELS grant holders and Stakeholders meeting in Hanoi, Vietnam 23th-24th January 2017. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Engagement and dissemination of research outcome to representatives of research funding bodies such as Department for International Development (DFID), Medical Research Council (MRC) and the researchers working on different research projects funded by BBSRC under Zoonoses and Emerging Livestock Systems (ZELS).
Year(s) Of Engagement Activity 2018
 
Description Conference session organiser at MMC2017 - Host Pathogen Interactions 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities.
Year(s) Of Engagement Activity 2012,2014,2015,2017
 
Description DARPA visit April 2017 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Hosted visit by US funding agency programme manager to The Pirbright Institute
Year(s) Of Engagement Activity 2017
 
Description Diamond open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Over 300 people visited our stand at the open day, in which we described the importance of our work for food security and public health. Children from all ages were involved and learned about viruses and played with the huge virus particle that we had produced. One of the major impact was that we described to several people why we work on some viruses that we do not have them in the UK, and the importance of the work for the UK and UK economy and public health was explained.
Year(s) Of Engagement Activity 2017
URL http://www.diamond.ac.uk/Public/VisitUs.html
 
Description EM-UK: A national network for electron microscopists 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Founder and Chair of EM-UK, a national network (with international participants) for electron microscopists. Includes a one or two day meeting with invited speakers, and email discussion list for questions, comments, advertising courses, advertising jobs. It has proved very popular with over 200 people registering for the discussion list, and 90+ delegates at each meeting. Administration is handled by the Royal Microscopical Society.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Ewen Callaway Nature 08/01/2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided expert background information for article in Nature regarding engineering species barriers, described by journalist as "very helpful" in followup email.
Year(s) Of Engagement Activity 2018
 
Description FAO/IAEA Coordinated Research Programme on methods of sex separation in mosquitoes; Research coordination meeting Bangkok 19-23 February 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FAO/IAEA Coordinated Research Programme on exploring genetic, molecular, mechanical, and behavioral methods of sex separation in mosquitoes; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field.
Year(s) Of Engagement Activity 2013,2015,2016,2018
 
Description Facebook Live: Infectious Disease Portrayals in Pop Culture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page.
Year(s) Of Engagement Activity 2017
URL https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture
 
Description Food security and the control of infectious disease in livestock 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A workshop was organized by myself at St Catherine's College Oxford for the duration of three days. Representative from industry, funding agencies and media (publishers) attended this workshop. Over 20 delegates from Egypt and 20 delegates from the UK attended this meeting. The purpose of this workshop/ meeting was to promote international collaborations, provide training for undergraduate students, promote the importance of managing and controlling infectious disease in livestock and public health.
Year(s) Of Engagement Activity 2016
 
Description Gnatwork Website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact New website established to act as focalpoint of project.
Year(s) Of Engagement Activity 2018
URL http://www.gnatwork.ac.uk/
 
Description Holly Kernot, Veterinary Times, 13/06/2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Discussed potential of manipulating mosquito sex determination genes as tools for novel mosquito genetic control approaches.
Year(s) Of Engagement Activity 2017
URL https://www.vettimes.co.uk/news/study-to-be-transformational-in-mosquito-control-strategies/
 
Description Human Infection Challenge Models Network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact HIC-Vac is an international network of researchers who are developing human infection challenge (HIC) studies to accelerate the development of vaccines against pathogens of high global impact. The goal is to foster an engaged and interactive community of international researchers to promote open sharing of knowledge and expertise, generate new ideas, support and share best practice, and form new cross-discipline collaborations.
Year(s) Of Engagement Activity 2018
 
Description InFocus article (Jennifer Simpson) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact InFocus review article for EM-UK meeting (2017)
Year(s) Of Engagement Activity 2017
 
Description Innovate Guildford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Institute stand at Innovate Guildford science festival. Visitors to stand able to discuss issues related to animal diseases and their control (with a particular focus on influenza and on use of genetic modification technologies)
Year(s) Of Engagement Activity 2017
 
Description Innovate Guilford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Dr Broadbent gave a talk at 'Innovate Guilford' Festival outlining the work we are doing with Avian Virus Vaccines, including those against IBDV. The aim was to raise public awareness on different avian viruses, and genetically modified vaccines.
Year(s) Of Engagement Activity 2017
 
Description Insect Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies).
Year(s) Of Engagement Activity 2017
URL https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/
 
Description Invitation to give keynote talk on 'Control of avian diseases: Challenges and opportunities' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave the Keynote talk on 'Control of avian diseases: Challenges and opportunities' at this International Symposium organized with an aim to gather international virology experts from both human and veterinary fields to share research experience, update findings and contribute their expertise through presentation and interactive discussion. The topics will cover a wide range of virology research common in both human and animal aspects. In addition, technological platforms such as vaccine development, and novel assays will be emphasized and addressed.
Year(s) Of Engagement Activity 2018
URL http://www.biotec.or.th/virus-symposium2018/index.php
 
Description Invited Seminar University College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited seminar at UCL to describe my ongoing research
Year(s) Of Engagement Activity 2018
 
Description Invited participant, Improving the Use of Evidence in Policymaking in the UK Government (Parliamentary Office of Science and Technology) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Invited to attend meeting to launch POST report "Improving the Use of Evidence in Policymaking in the UK Government" as a result of previous collaboration.
Year(s) Of Engagement Activity 2017
URL http://www.sciencecampaign.org.uk/resource/casereportimprovingtheuseofevidence2017.html
 
Description Invited seminar at UC Riverside 05/05/2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited seminar at University of California, Riverside
Year(s) Of Engagement Activity 2017
 
Description Invited seminar at the National Health Research Institutes, Taiwan. 27 Feb 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation describing research in my group on mosquito developmental biology and its potential uses for mosquito control; attended by primarily by members of the National Mosquito-Borne Diseases Control Research Center.
Year(s) Of Engagement Activity 2018
 
Description Invited seminar at the University of Nottingham seminar series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact An invited seminar entitled: "Arbovirus encephalitis: from tissue culture, to mosquitoes to mice" was delivered. Discussions for potential collaborations followed.
Year(s) Of Engagement Activity 2017
 
Description Invited seminar in Public Health England- Porton Down 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited seminar entitled: "Innate immune responses and pathogenesis of alphavirus infections". Numerous questions were asked and requests for collaborations were made.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at 9th Neuroinfections Conference, Bialowieza - Poland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An invited presentation entitled: "Using small RNAs to fight encephalitic arboviruses" was delivered. The presentation generated a lot of interest and questions.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at 9th Neuroinfections Conference, Bialowieza - Poland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An invited talk entitled: "Using small RNAs to fight encephalitic arboviruses" was delivered. Numerous questions were asked.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at South Wilts Virus Group (SWVG) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A talk entitled: "The role of small RNAs in arbovirus infections". Multiple questions were asked and potential for collaborations was identified.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at a workshop on arboviruses and their vectors in University of Malaya - Malaysia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk entitled: " The role of small RNAs in arbovirus infections" was delivered. Multiple questions and requests for collaborations followed the presentation.
Year(s) Of Engagement Activity 2017
 
Description Invited to talk at the International Conference on Building Human and Animal Health Capacities organised by the Jordan University of Science and Technology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated in the discussion and talked on 'The recent advances in vaccination-based control of poultry diseases'. The need for increased awareness of the pathogen diversity in the design of vaccines and the opportunities from advances in vaccine technologies were discussed
Year(s) Of Engagement Activity 2017
URL http://www.just.edu.jo/conferences/bhahc/Pages/default.aspx
 
Description Keynote talk at the World Veterinary Poultry Association meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to give the keynote talk on 'Avian tumour viruses: their contribution to our understanding of cancer' at the World Veterinary Poultry Association XXth Congress in Edinburgh
Year(s) Of Engagement Activity 2017
URL http://www.wvpac2017.com/
 
Description Lecture given to University of Surrey MSc Veterinary Microbiology students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup)
Year(s) Of Engagement Activity 2017
 
Description Lecture of dynamics of vector-borne diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at Univerity of Cambridge
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
 
Description Lecture on dynamics of infectious diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture as part of MSc in Veterinary Microbiology at University of Surrey
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016
 
Description MMC2017 Learning Zone seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Presented a seminar on preparation of samples for electron microscopy to 24 MMC2017 delegates. Questions followed asking for advice on specific examples, also advice on interpretation of data and how to improve results.
Year(s) Of Engagement Activity 2012,2015,2017
 
Description MSc student visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I hosted ten MSc students from University of Surrey, discussed avian research with them and demonstrated some laboratory techniques. The students gained an understanding of academic research and laboratory work.
Year(s) Of Engagement Activity 2018
 
Description Malaysia workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Organised and participated in workshop on genetic control of mosquitoes, primarily focusing on refractory methods. Included a set of open lectures from international speakers at University of Malaysia and more focus workshop-style meetings. Several reported changes to research activities and also opinions, also follow-up meeting organized in Glasgow later in 2017
Year(s) Of Engagement Activity 2017
 
Description Medical and Veterinary Virus Research Symposium (MVVR) Kenya 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk at international conference on One Health research in Kenya
Year(s) Of Engagement Activity 2017
 
Description Microbiology Today article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018).
Year(s) Of Engagement Activity 2018
 
Description Networking presentation-INRA, Paris, France 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation at INRA describing the role of the SH protein of BRSV in modulating immune responses in calves. This presentation resulted in a heated debate on the role of viral proteins in immune evasion and their activities in attenuated vaccines.
Year(s) Of Engagement Activity 2017
 
Description Nick Rufford, Sunday Time Mag, published 27/08/2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Provided information and quotes for Sunday TImes Magazine article on GM mosquitoes and Zika
Year(s) Of Engagement Activity 2017
URL https://www.thetimes.co.uk/article/how-genetically-engineered-mosquitoes-will-save-lives-kwc8nmwh5
 
Description Nidovirus symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I presented my work at the Nidovirus Symposium, which is held every three years and brings together researchers from industry and academia from many different countries. I had some interesting discussions with other researchers and built my network.
Year(s) Of Engagement Activity 2017
 
Description Oral presentation at the Microbiology Society annual meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An oral presentation on Inhibition of Semliki Forest Virus Replication Through Disruption of Lipid Homeostasis was delivered. The audience showed high interest and a good discussion and exchange of ideas followed the presentation.
Year(s) Of Engagement Activity 2017
 
Description Oral presentation to Large Animal Research Network 24th May 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Talk about work understanding PB1-F2 function in avian hosts highlighting how the animal work carried out was undertaken and monitored. this was delivered to an audience of researchers, funders and industry interested in animal model systems for research and the 3Rs commitment surrounding this work. Discussions with interested parties about our chicken work at the Institute and the diverse way that the birds are entertained whilst being housed (e.g. live food, vegetables, perches, dust baths etc).
Year(s) Of Engagement Activity 2017
 
Description Organisation of UK-India Bioinformatics Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The meeting discussed the challenges and opportunities and have decided to come up with a strategy document on working together between UK and India on data-driven biology
Year(s) Of Engagement Activity 2018
 
Description Organised the 3rd UK-China CERAD meeting in Guildford, UK in July 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The 3rd UK-China CERAD meeting helped to bring together professional from both countries to identify challenges and exploit the opportunities for improved control of poultry diseases and increasing food security.
Year(s) Of Engagement Activity 2017
URL http://www.uk-china-cerad.org/
 
Description Organising and giving Keynote talk at the GARAD meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Global Alliance of Poultry industry professional and academia to discuss about the advances in control strategies of diseases
Year(s) Of Engagement Activity 2018
URL http://Garad.org
 
Description Outreach at TeenTech Events 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact TeenTech runs lively initiatives with a supporting Award scheme to help young teenagers see the wide range of career possibilities in Science, Engineering and Technology. They work collaboratively with companies, Universities, business organisations and education business partnerships to build sustainable and imaginative programmes focussing on regions of greater social need in the UK and Europe. This outreach actvity involved primarily school children aged 12/13. Several hundred attended and our attendees (Laura Tugwell) spoke with about 30-40 children/teachers.
Year(s) Of Engagement Activity 2017
URL http://www.teentech.com/
 
Description Oxford DTP students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017).
Year(s) Of Engagement Activity 2017
 
Description Participant in IDEAS arboviruses workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018).
Year(s) Of Engagement Activity 2017
URL http://ideas.princeton.edu/workshop-for-2017/
 
Description Participation in student day at the Pirbright Institute 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Student open day was participated by postgraduate students registered at several Universities, and scientists from Pirbright institute. Students were given a chance to discuss their research activities and future plans with senior scientists. Due to high interest from the students, the institute has decided to organize another open day.
Year(s) Of Engagement Activity 2016
 
Description PhD course in Electron Microscopy 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Intensive workshop containing lectures and practicals in the use of electron microscopy in life sciences. This takes place every year at the University of Copenhagen, I am a course organizer and invited speaker.
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016
 
Description Pirbright Pride day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Set up a stand at the described our research, engaged with policymakers, industry and participants from other organizations and distributed leaflets.
Year(s) Of Engagement Activity 2015
 
Description Population Biology of Vector-Borne Diseases Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018
Year(s) Of Engagement Activity 2018
 
Description Poster presentation in the IMAV focused meeting on Arboviruses 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A poster on Inhibition of Semliki Forest Virus Replication Through Disruption of Lipid Homeostasis was presented at the IMAV meeting. The poster generated a lot of discussion and interest.
Year(s) Of Engagement Activity 2017
 
Description Poultry Health course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poultry Health Course is run as a residential and online course to transfer recent advances in avian disease research from the laboratory to the field.
Year(s) Of Engagement Activity Pre-2006
URL http://www.poultryhealthcourse.com/
 
Description Practical training given to LSHTM MSc students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Two-hour practical teaching session given to 12 MSc students at the London School of Hygiene and Tropical Medicine (LSHTM) on 17th November 2017 (Lara Harrup).
Year(s) Of Engagement Activity 2017
 
Description Presentation and sicussion with members of the CLA group visiting Pirbright Institute 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a visit to the Pirbrigtht Institute and I presented on Bluetongue virus epidemiology, transmission and risk to the UK agriculture followed by a general discussion
Year(s) Of Engagement Activity 2017
 
Description Presentation at Global Alliance for Research on Avian Diseases Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation of my research at the Global Alliance for Research on Avian Diseases Conference in Vietnam to approximately 80 conference participants resulted in discussions about future research directions.
Year(s) Of Engagement Activity 2018
 
Description Presentation at RIVR meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Presentation of my research at Recently Independent Virology Researchers (RIVR) meetings in 2016, 2017 and 2018. I discussed my work and future collaborations with other virology researchers working in the UK.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Presentation at the Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Cheltenham Science Festival is one of the UK's leading science festivals. Founded in 2002, the Cheltenham Science Festival has united some of the greatest scientists, writers and thinkers to explore the wonders of the natural world, the complexities of the human mind and the mysteries of science and space. It was an opportunity for inquisitive minds of all ages to find out more about the world of science. The audience included Key Stage 1-3 students on the start of their education which in turn could lead to future careers in science. The main purpose was to engage with various stakeholders from different backgrounds to inform and educate the general public on BBSRC-funded science which is carried out at the Pirbright Institute. During the talk I was able to demonstrate that basic science can have practical implications.
Year(s) Of Engagement Activity 2016
URL http://www.cheltenhamfestivals.com/science
 
Description Presentation by ND at Nidovirus symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The post-doctoral researcher presented our data at the 14th international Nidovirus symposium. She discussed data and potential collaboration with other scientisits from the field.
Year(s) Of Engagement Activity 2017
 
Description Presentation by RH at Nidovirus symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact PhD student presented our data at the 14th international Nidovirus symposium. He discussed results and potential for future collaboration with other scientists in the field.
Year(s) Of Engagement Activity 2017
 
Description Presentation: BSI AGM: Immune regulation by the SH protein of BRSV 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at the BSI's AGM to describe the data generated regarding the role of the SH protein of BRSV in regulating immune responses after natural infections. Initiated a debate about the role of the SH protein of human RSV in immune regulation.
Year(s) Of Engagement Activity 2017
 
Description Princess Anne opening Jenner 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Princess Anne, entourage, local politicians and dignitaries visited to open new research building. I was one of small number asked to present/demonstrate/describe our research work, which is on genetic modification of mosquitoes to provide new tools with which to help control mosquito-borne viral diseases.
Year(s) Of Engagement Activity 2017
 
Description Public Health Entomology Group (LSHTM) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture on 4th April 2017.
Year(s) Of Engagement Activity 2017
 
Description Public engagement organized at Oxford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Set up a stand at the event, a museum at Oxford, and discussed and described research activities within the Institute with public. Set up demonstrations from some biological specimens and distributed leaflets and questionnaire.
Year(s) Of Engagement Activity 2015
 
Description Reddit AMA (Ask Me Anything) on vector-borne diseases 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+.
Year(s) Of Engagement Activity 2017
URL https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/
 
Description Reverse genetics seminar to MSc students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A seminar was presented describing reverse genetics of viruses, including infectious bronchitis virus and the application of reverse genetics in research. The students were interested and engaged, participating in activities and asking questions. We were invited to present the seminar in subsequent years for new student intakes.
Year(s) Of Engagement Activity 2013,2014,2015,2016,2018
 
Description Royal Society of Biology Biology week talk, Winchester, 10/10/2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk organized by Royal Society of Biology as part of Biology Week. This one in Winchester, audience was general public with strong representation of school-age. Questions and discussion during and after formal talk.
Year(s) Of Engagement Activity 2017
 
Description SGM Meeting 2017 Presentation: Regulation of the transcription factor NF=kB by the SH protein of BRSV 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at a workshop of the Society for General Microbiology on the role of the SH protein of BRSV in regulating the transcription factor NF-kB in bovine antigen presenting cells. Many questions about protein-protein interactions were generated. Good feedback on our work.
Year(s) Of Engagement Activity 2017
 
Description Scheduled Twitter session with University of Nottingham students on professional skills for biosciences 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/search?q=%23biosciprofskills
 
Description School visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed different aspects of scientists' work.
Year(s) Of Engagement Activity 2017
 
Description School visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Met and discussed A level students in small groups (3 students at the time) and discussed different aspects of my work as a scientist.
Year(s) Of Engagement Activity 2015
 
Description Scientific Presentation: SOVE lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Society of Vector Ecology Presentation 'The Gnatwork'. 6th October 2017 over 150 attendance.
Year(s) Of Engagement Activity 2017
URL http://www.uibcongres.org/sove2017/
 
Description Site tour with Department of Trade and Industry 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Tour/site visit with Department of Trade and Industry (25 people attending)
Year(s) Of Engagement Activity 2017
 
Description Site tour with UK Science Partnership for Animal and Plant Health, BBSRC (Chris Jacobs, Julie Fitzpatrick) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact 'Fact-finding' visit from Chris Jacobs (Head of Secretariat, UK Science Partnership for Animal and Plant Health) & Julie Fitzpatrick (Chair of the Partnership) to organisations involved in the areas of animal and plant health science capabilities, to gain a better understanding of who the key players are, what they're working on, and any particular issues the Partnership may be able to address.
Year(s) Of Engagement Activity 2017
 
Description St Andrew's Catholic School visit to Pirbright 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact College students visited the Institute to learn about lab designs. They were given talks about the equipment and labs and then toured around the labs at Pirbright. Students were highly interested about our facilities and the work we are conducting at The Institute.
Year(s) Of Engagement Activity 2016
 
Description Surrey County Show (Guildford) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Stall at Surrey County show attended by Jo Stoner (Research Technician). Gave commentary on the threat of viruses to UK livestock species.
Year(s) Of Engagement Activity 2017
URL http://surreycountyshow.co.uk/
 
Description Surrey Open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Described the research activity of the Pirbright Institute for students from school, graduate and postgraduate students, and provided information on research facilities in the institute.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/opendays/vet
 
Description Talk at the Merseyside BSI Affinity group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact I described the methods we used to identifyTissue resident memory cells in pigs, which sparked a lively discussion and interest in the technique. As a result I have established two collaborations with colleagues from Liverpool.
Year(s) Of Engagement Activity 2018
 
Description Talk to Agrifood and Biosciences Institute, Northern Ireland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Formal presentation on Culicoides-borne arboviruses with discussion of impact in Northern Ireland
Year(s) Of Engagement Activity 2017
 
Description Teaching- lecturing, small group classroom teaching and laboratory practical teaching 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact I have been actively engaged with teaching activities at the University of Surrey, giving lectures, small group classes and laboratory practical classes to vet students and MSc students.
Year(s) Of Engagement Activity 2015,2016,2017
 
Description Toolbox workshop at IVVN Stirling 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact A second workshop held as a sattelite meeting to the International Veterinary Vaccinology Conference in Stirling to decide on community priorities for future immunological tools to promote veterinary vaccine development.
Year(s) Of Engagement Activity 2012,2018
 
Description Tour of Philip Mellor Insectary (BBSRC) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact BBSRC tour of Philip Mellor Insectary on 4th December 2017 (Jo Stoner).
Year(s) Of Engagement Activity 2017
 
Description Tour of Philip Mellor Insectary (Country Land and Business Association) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Tour of Philip Mellor Insectary with Country Land and Business Association (20 people)
Year(s) Of Engagement Activity 2017
 
Description Tour of Pirbright Research facilities for CLA group 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a tour of the Jenner building facilities at The Pirbright Institute. I led a tour of our building for the group and described the work undertaken by the avian research programme here.
Year(s) Of Engagement Activity 2017
 
Description University of California Davis School of Veterinary Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact External Meeting at University of California Davis School of Veterinary Medicine, 16-18th October 2017. Talk given (Lara Harrup) on 'Tools and Resources for Arbovirus Epidemiology in the Genomic Era'. Meeting organised as part of the University of Liverpool BBSRC US Partnering Award: Vector-borne diseases in the UK & US: common threats and shared solutions (BB/N021916/1).
Year(s) Of Engagement Activity 2017
 
Description University of Surrey Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I represented The Pirbright Institute at the University of Surrey Vet School open day, talking about my research and what it is like to be a research scientist.
Year(s) Of Engagement Activity 2015
 
Description VetVac toolbox kick off meeting, Pirbright 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Organsised a workshop part sponsored by the BBSRC Veterinary Vaccinology Network that bought key international leaders in veterinary immune reagents together to discuss lessons from the past and how we should progress in the future, reaching as wide an audience as possible.
Year(s) Of Engagement Activity 2017
 
Description Veterinary Research Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation of the data generated and its importance in understanding immune responses to vaccination and natural infections. About 50 veterinarians and researchers working in veterinary sciences attended the one-day meeting, which initiated discussions about the possibility of generating new vaccines against BRSV.
Year(s) Of Engagement Activity 2017
 
Description Virtual video tour of the animal facilities in Pirbright 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Contributed to public understanding of animal research by being interviewed on the virtual video tour of the animal facilities in Pirbright - one of only four such initiatives in the UK.
Year(s) Of Engagement Activity 2017
 
Description Volunteered at a school open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I represented The Pirbright Institute talking at a school about my research and what it is like to be a research scientist.
Year(s) Of Engagement Activity 2015
 
Description a talk at the Recently Independent Virology Investigators meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I gave a talks outlining my current research and future plans.
Year(s) Of Engagement Activity 2015,2016,2017
 
Description organised workshops at Microbiology Society annual conferences 2014 - 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I co-organised virology division workshops on viral evolution and diversity and RNA viruses with colleagues from the virology division. The workshops were held at the annual Microbiology Society conferences in spring each year. Organisation involved selecting abstracts for oral or poster presentation, ordering the presentations and chairing the sessions.
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description talk to the U3A 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I gave a talk to the University of the 3rd Age (U3A)- a group of the general public above the age of 65.
Year(s) Of Engagement Activity 2016