Science Services

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

Within the area of Science Services we have identified five areas that are vital for the efficient running of science for both internal and external users of materials and facilities. These are (1) Insectary Support; (2) Bioimaging; (3) Immunological Resources Support; (4) Sequencing and Bioinformatics; (5) Proteomics. These are national capabilities either due to the specialised and costly containment infrastructure required for their running and maintenance or that they have been built up as a result of long-term strategic funding and heavy use by both internal and external users.

The Science Services National Capability has been used to address COVID-19 related challenges from 1 April 2020.

Organisations

Publications

10 25 50
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Baron MD (2018) Recent advances in viral vectors in veterinary vaccinology. in Current opinion in virology

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Ali M (2019) Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015. in Emerging infectious diseases

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Alber A (2021) The bird's immune response to avian pathogenic Escherichia coli. in Avian pathology : journal of the W.V.P.A

 
Title E17 Art Trail - STEAM theme (Jennifer Simpson) 
Description Laboratory of Tiny Things installation which ran in London for three weeks. Open to the general public. 
Type Of Art Image 
Year Produced 2017 
Impact No known impact 
 
Title The Pathologist - Through the Looking Glass (Jennifer Simpson) 
Description Article showcasing a gallery of beautiful images from all walks of laboratory medicine 
Type Of Art Image 
Year Produced 2017 
Impact No impacts known 
 
Description The Science Services strategic grant provides unique resources to scientists both within and external to Pirbright. During the reporting period to date we have 1) Supplied insects to a variety of external users under MTA (ongoing). Outputs have included the analysis of gut microbiota in Culicoides biting midges and studies of their vector competence for arboviruses. In addition, industrial income has been met as estimated within the impact plan and a total of >20 MTA's are extant for midge and mosquito supply. Staffing has also been strengthened towards lab management of the two main insectary facilities in line with requirements of users and areas requiring containment level 3 techniques have also been strengthened by the addition of a dedicated lab manager. 2) Bioimaging facilities for internal users have been maintained with more than 50 registered users and a range of outputs in line with impact plan estimates derived from both microscopy and flow cytometry techniques. Workers in this area have retained direct links to relevant societies and provided a range of materials for outreach activities. In addition, a new strategic collaboration has been established with the Electron Bioimaging Centre at Diamond Light Source and a bid for a new Transmission Electron Microscope has been successful to facilitate this work (2019). 3) Sequencing of hybridoma collections has been initiated (>50 to date) and a committee formed for selection and distribution of resources that includes national and international experts (2017). This is aimed at providing immunological resources that are not commercially viable but nonetheless a limiting factor in studies of host and virus. Outputs include a dedicated website that is accessible to the public and enables searching and ordering of available reagents (2019). 4) In addition to the current MiSeq facility, a HiSeq Illumina sequencer has been installed (2018) and is running in containment and single cell encapsulation technology is in preliminary trials (2019). A total of 14 research groups have accessed these facilities to date (2019). 5) Proteomics support has been provided to at least seven internal groups and has also been assessed across site with a significant increase in demand.
Exploitation Route Facilities within Science Services are provided across the groups at Pirbright and all receive at least some provision of support within the five distinct areas. We have targeted insect supplies and the immunological toolbox as being the most straightforward to provide to external users and both of these areas are progressing in making resources available. Both of these areas rely on centralizing both expertise and resources which would not be normally be supported at a single institution, improving both continuity and critical mass and are within the range of reporting identified within the impact plan. Bioimaging and sequencing in containment operate on a slightly different model of external access due to the constraint of the training required to access facilities, but plans are in place to improve the numbers accessing resources later in the ISPG programmes. The proteomics service is a purely internal service operated in collaboration with the University of Liverpool.
Sectors Agriculture, Food and Drink

 
Description The provision of Science Services has played a major role in underpinning a range of scientific discoveries outlined in the publications produced to date. These impacts would not be achieved without the supporting services described in this ISPG, facilitating a diverse collection of areas. Major areas include the use of DNA/RNA sequencing in containment where samples cannot be outsourced for this service and the production of both insect and animal lines that are unique to Pirbright under the national capability initiative. In addition, the development of bioimaging in containment has led to discussion with other groups active in the field in the UK and the formation of a working group around developing techniques. The production of insect and vertebrate hosts for viruses also forms a major aspect of our aim to carry out studies of virus infection in the natural hosts in addition to providing opportunities for methods to vaccinate or protect from infection.
First Year Of Impact 2017
Sector Agriculture, Food and Drink
Impact Types Societal,Economic,Policy & public services

 
Description BBSRC 18ALERT panel member
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Provision of multi-user equipment to core facilities to enable BBSRC remit science. Part of the remit for this call was to allow shared access from other institutions, widening the impact of BBSRC investment.
 
Description BBSRC ALERT19 panel member (invited)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Panel for ALERT18 multi-user equipment award by BBSRC
 
Description BBSRC Bioimaging Review
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description BBSRC-Newton Fund Agricultural Data Re-use Advisory Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Advice on re-usability of data generated in research projects.
 
Description Bioimaging Steering Group
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
Impact Improving access and efficient organization of Bioimaging for researchers at Pirbright
 
Description Contribution to a POSTnote on 'Reducing UK Antibiotic Use in Animals'
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description IUCN Assessment of Synthetic Biology and Biodiversity Conservation
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL https://www.iucn.org/theme/science-and-economics/our-work/other-work/synthetic-biology-and-biodivers...
 
Description Inter-institute imaging network
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Invited member of RCaH Science Advisory Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact The Research Complex at Harwell is a UKRI funded building with the remit of enabling researchers across many disciplines to take advantage of the national facilities on the Harwell campus. RCaH is going through significant change at the moment and the advisory board has been asked to contribute to defining its future direction.
 
Description Lumpy Skin Disease Control Strategy for Great Britain
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Member of RMS EM Section committee
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact This committee informs the RMS on which areas to invest funds in regarding training, conferences, outreach events. RMS members are international.
 
Description Membership of MPEG-G (standardisation of the compression of genomic information) working group
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Organised seminar series on Sequencing, Virus Evolution and Molecular Biology at Pirbright (with Luca Ferretti and Graham Freimanis)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description POSTnote Report on Climate and vector-diseases in humans in the UK
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Publication policy document for core facilities - EM-UK
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact I am a founder member of the network created for electron microscopists within UK, EM-UK. The annual meeting is highly productive, and training and managing core facilities is regularly discussed. Recognition of these facilities is essential for their continued existence so we produced a generic document hosted on the RMS website which can be adopted by any core facility in any institution, and describes the publication policy which users had to adhere to. This has already raised the profile of core facilities around the country and is a successful outcome from the EM-UK meetings.
 
Description Royal Microscopical Society Microscopy Training Focussed Interest Group
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Royal Microscopical Society Training Focussed Interest Group
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact A review of the microscopy training courses available globally has been undertaken. We are in the process of collating and preparing a gap analysis. This will be used to guide RMS policy on training provided in the UK, both UK and international delegates.
 
Description Scientific Advisory Group for Emergencies Exercise (Royal Society: 11/06/19): Examined simulated emergence of arbovirus in the UK with main decision making bodies and personnel.
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Training MSc students
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Delivered a new training session to MSc students teaching viral quantification assays. This lead to a greater understanding of laboratory techniques and academic research.
 
Description University of Surrey MSc Vet microbiology - teaching (Jennifer Simpson)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Two days of teaching practical microscopy, a useful cross disciplinary skill for many researchers
 
Description (CloudButton) - Serverless Data Analytics Platform
Amount € 4,277,507 (EUR)
Funding ID 825184 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2019 
End 12/2021
 
Description A One Health approach to pan-valent morbillivirus vaccines
Amount £773,237 (GBP)
Funding ID BB/R019843/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 03/2021
 
Description Antigenic characterisation of infectious bursal disease virus to improve vaccination strategies and vaccine design
Amount £450,685 (GBP)
Funding ID BB/S014594/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2019 
End 12/2021
 
Description Assessing the functionality of avian BST2 as a viral restriction factor.
Amount £50,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2021 
End 09/2025
 
Description Assessment of the immunogenicity of bovine herpesvirus 4-based vectors delivering Nipah virus glycoproteins in swine
Amount £41,895 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 02/2019 
End 04/2019
 
Description Aviagen Industry Funding
Amount £422,383 (GBP)
Organisation Aviagen Group 
Sector Private
Country United States
Start 09/2019 
End 12/2020
 
Description BBSRC IAA The Pirbright Institute
Amount £300,000 (GBP)
Funding ID BB/S506680/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2021
 
Description BBSRC Industrial CASE (iCASE) studentship programme Oxford Interdisciplinary Bioscience Doctoral Training Partnership
Amount £80,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 09/2023
 
Description BBSRC business case for sequencing capacity in containment.
Amount £560,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 03/2018
 
Description BBSRC responsive mode grant
Amount £367,000 (GBP)
Funding ID BB/P006841/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 03/2019
 
Description Biotechnology and Biological Sciences Research Council (BBSRC) and University of Oxford joint Doctoral Training Project
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description British Egg Marketing Board PhD studentship
Amount £76,000 (GBP)
Organisation British Egg Marketing Board 
Sector Private
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Broad and effective protection against influenza achieved by viral vectored vaccines
Amount £1,607,691 (GBP)
Funding ID MR/S037160/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2019 
End 04/2022
 
Description Capital Infrastructure - PIrbright
Amount £23,533 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 12/2017
 
Description Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence
Amount £200,000 (GBP)
Funding ID LKCS-2019- 665 
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 10/2022
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti
Amount £1,209,348 (GBP)
Funding ID BB/S001964/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2021
 
Description DARPA PREEMPT
Amount $2,700,000 (USD)
Organisation Defense Advanced Research Projects Agency (DARPA) 
Sector Public
Country United States
Start 10/2018 
End 03/2022
 
Description Defining the circadian clock in chicken cells and its impact upon viral replication
Amount £4,500 (GBP)
Organisation The Houghton Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 11/2020
 
Description Development of next generation vaccine technology inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells
Amount £473,080 (GBP)
Funding ID BB/T013087/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2020 
End 05/2023
 
Description EU VetBioNet Transnational Access Fund: Evaluation of the immunogenicity of a bivalent PRRS-Nipah virus vaccine
Amount £61,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2021 
End 07/2021
 
Description Enhancing protective efficacy of avian influenza vaccines through targeted delivery of protective antigens to chicken immune cells
Amount £98,212 (GBP)
Funding ID BB/R50595X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2017 
End 09/2021
 
Description Genomia Project Grant
Amount £174,052 (GBP)
Organisation Genomia fund 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2019 
End 01/2020
 
Description H2020 work programme topic 9 Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy, work topic SFS-10-2017 Research and approaches for emerging diseases in plants and terrestrial livestock
Amount € 5,986,250 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 05/2018 
End 04/2023
 
Description Identification and evaluation of swine mAbs in pig influenza challenge model
Amount $599,944 (USD)
Funding ID OPP1201470 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2018 
End 10/2019
 
Description In vitro evaluation of peptide-based immune checkpoint inhibitors as potential molecular adjuvants for improved PRRS vaccines
Amount £4,921 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 08/2019 
End 03/2020
 
Description Market research and technical feasibility of a bivalent porcine reproductive and respiratory syndrome / Nipah virus vaccine
Amount £10,880 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 07/2019 
End 03/2020
 
Description NC3Rs Research Project Grant
Amount £436,339 (GBP)
Funding ID NC/R001138/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2017 
End 11/2019
 
Description OIE Twinning: Development of capacity for independent assessment of FMDV vaccines in Africa
Amount $1,466,186 (USD)
Organisation World Organisation for Animal Health 
Sector Public
Country France
Start 04/2019 
End 03/2021
 
Description Oxford DTP - Diamond Light Source/Harwell
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Pirbright Institute Flexible Talent Mobility Account
Amount £180,000 (GBP)
Funding ID BB/S507945/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 03/2021
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 09/2023
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description Recombinant pseudorabies virus as a multivalent vectored vaccine platform for emerging and endemic porcine diseases
Amount £80,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2020 
End 09/2024
 
Description Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field.
Amount £400,000 (GBP)
Funding ID BB/S013792/1 
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 01/2021
 
Description SFS-10-2017 - Research and approaches for emerging diseases and pests in plants and terrestrial livestock: Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND)
Amount € 5,986,250 (EUR)
Funding ID 773701 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 06/2018 
End 05/2023
 
Description Seed Catalyst Award
Amount £25,527 (GBP)
Funding ID ISCF-TFPSA-Pirbright 
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 11/2018 
End 02/2019
 
Description Smart biomimetic nanomaterials for novel treatment and prevention of viral infection
Amount £60,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2019 
End 03/2022
 
Description The Global Challenges Research Fund
Amount £640,473 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2024
 
Description The Pirbright Institute - University of Surrey PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 03/2023
 
Description The Pirbright Livestock Antibody Hub
Amount $5,530,900 (USD)
Funding ID INV-003007 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2019 
End 09/2024
 
Description The Pirbright Livestock Antibody Hub
Amount NU$ 5,500,000 (UYU)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2019 
End 08/2024
 
Description Towards a novel multivalent poultry vaccine: Development of a recombinant infectious bursal disease vectored vaccine encoding conserved B- and T- cell epitopes from infectious bronchitis virus
Amount £5,000 (GBP)
Organisation The Houghton Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 11/2020
 
Description Workpackage within a Horzion 20:20 grant
Amount € 6,000,000 (EUR)
Funding ID EU project 727393 Horizon 20:20 PALE-Blue 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 06/2017 
End 11/2020
 
Description [YY-EEID US-UK XXXX] Evaluating how immunosuppression influences influenza A virus transmission and evolution in wild and domestic birds
Amount £606,360 (GBP)
Funding ID BB/T008806/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2023
 
Description iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 09/2023
 
Title A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system 
Description we developed an easy and efficient ligation and restriction enzyme independent (LREI) cloning method for cloning influenza gene segments into pHW2000 vector. The method involves amplification of megaprimers followed by PCR amplification of megaprimers using a bait plasmid, DpnI digestion and transformation. ligation and restriction enzyme independent (LREI) cloning method represents an alternative strategy for cloning influenza gene segments that have internal restriction sites for the enzymes used in reverse genetics. Further, the problem of genetic instability in bacteria can be alleviated by growing recombinant bacterial cultures at a lower temperature. This technique can be applied to clone any influenza gene segment using universal primers, which would help in the rapid generation of influenza viruses and facilitate influenza research and vaccine development. 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact The method will help in the rapid generation of reverse genetic base influenza viruses and facilitate influenza research and vaccine development. 
URL https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01358-2
 
Title A male-specific cell line from a mosquito Anopheles gambiae 
Description A new male-specific cell line from a mosquito Anopheles gambiae has been isolated from sexed neonate larvae. To our knowledge this is the only cell line derived exclusively from male mosquitoes. 
Type Of Material Cell line 
Year Produced 2019 
Provided To Others? No  
Impact The cell line will greatly facilitate studies on components of the sex determination pathway and of dosage compensation machinery in mosquitoes. There are only several cell lines derived from Anopheles gambiae available and these are female-like. Over-expression of genes involved in male sex determination or dosage compensation is detrimental to female cells, hence use of male-derived cells is necessary for such studies. The cell line will become available upon acceptance of a manuscript describing characterization of that cell line. 
 
Title An ex vivo IBDV infection model using a chicken primary B cell culture system 
Description Recently, it has become possible to culture chicken primary B cells in vitro in the presence of a soluble construct of chicken CD40L that was made at The Pirbright Institute. We have demonstrated that these chicken primary B cells can be infected with infectious bursal disease virus (IBDV). This system will be validated and expanded to other B cell tropic viruses in order to replace the use of infected chickens in research, in an NC3Rs funded grant. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2017 
Provided To Others? Yes  
Impact Using this system, we have determined that chicken primary B cells respond to IBDV infection by inducing Type I IFN responses. However, the induction is more pronounced in cells infected with an attenuated strain compared to a very virulent strain. This is consistent with the very virulent strain down-regulating antiviral responses to a greater extent than other strains which may, in part, explain its enhanced virulence. We also observed a reduction in the expression of key genes involved in B cell proliferation and activation following IBDV infection which was only possible by using the primary B cell culture system. 
URL https://www.ncbi.nlm.nih.gov/pubmed/?term=broadbent+dulwich
 
Title Appropriate FMD vaccine strains for East Africa and South East Asia and new adjuvants for FMD vaccines that provide longer duration immunity 
Description We have identifies appropriate Vaccine strains for Serotyoe O and A for East Africa and for South east Asia which are published now. Additionally we have identified potent and safe adjuvants which has been tested in cattle and provides longer duration immunity. 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Governments of East Africa and Regional OIE centre at South East Asia and vaccine producers are aware about the strains and adjuvants. 
 
Title CRISPR/Cas9-based gene editing of avian herpesvirus vectors to develop novel recombinant vaccines 
Description Development of recombinant herpesvirus vaccines are usually achieved by classical homologous recombination methods. The advent of new genome editing tools has enabled its application on avian herpesvirus vaccine strains to develop new recombinant vaccines potentially capable of expressing protective antigens from multiple pathogens 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The major impact will be in the generation of novel vaccines that can simultaneously protect against multiple avian diseases 
URL http://www.poultryworld.net/Health/Articles/2016/12/Is-GM-technology-the-future-of-poultry-vaccines-...
 
Title Cattle MHC genotyping 
Description Using the sequence data generated through the targeted pull down of MHC, we developed a full gene and more targeted PCR approach to genotype cattle for the MHC class I region. This has been applied to many hundreds of samples to enable us to select individuals for breeding as well as survey genetic diversity in beef and diary herds. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact After publication which we anticipate in 2019, we will appy this method to targeted herds and are already attracting industry interest. 
 
Title Deep sequencing to identify RNA packaging signals 
Description A novel and simple approach to identify predicted RNA secondary structures involved in genome packaging in positive sense RNA viruses (e.g. the picornavirus foot-and-mouth disease virus [FMDV]). By interrogating deep sequencing data generated from both packaged and unpackaged populations of RNA, we have determined multiple regions of the genome with constrained variation in the packaged population. Predicted secondary structures of these regions revealed stem-loops with conservation of structure and a common motif at the loop. Disruption of these features resulted in attenuation of virus growth in cell culture due to a reduction in assembly of mature virions. This study provides evidence for the involvement of predicted RNA structures in picornavirus packaging and offers a readily transferable methodology for identifying packaging requirements in many other viruses. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact Impact so far is fundamental knowledge but with several potential avenues for future impact in for example improved vaccines. 
 
Title Detection of HA antigens of avian influenza viruses 
Description Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. 
 
Title Development of SARS-CoV-2 pseudotypes 
Description Method to allow assessment of SARS-CoV-2 entry, which can be used in various experiments including VNTs to assess humoral immune response (in convalescent or vaccinated individuals) 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact Application in the establishment of the SARS-CoV-2 international reference standard by NIBSC 
 
Title Development of assays for quantifying fusion inhibitory antibodies in sera (mFIT assay) 
Description We have developed a micro-fusion inhibition test (mFIT) assay to identify and quantify antibody responses (to vaccines etc.) which are capable of inhibiting viral induced cell-cell fusion. This test has been developed for various negative strand viruses (Nipah and RSV) as well as SARS-CoV-2 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact This assay was used to aide development of the NIBSC WHO international standard for SARS-CoV-2 
 
Title Development of high-throughput assay for examining paramyxovirus fusion 
Description We have developed and optimised high-throughput assays (96 well plate format) to examine paramyxovirus fusion, using an adapted Bi-FC approach. We are using this to identify inhibitors of paramyxovirus, e.g. measles and RSV, fusion and attachment proteins. This has been integrated with next-generation platforms such as the Incucyte real-time imaging system available at The Pirbright Institute. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact We are using this assay to examine the innate immune restriction of paramyxovirus replication. 
 
Title Fluorescence Recovery after Photobleaching (FRAP) of infectious bursal disease virus (IBDV) replication factories 
Description Fluorescence Recovery after Photobleaching (FRAP) of infectious bursal disease virus (IBDV) replication factories. 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? No  
Impact We have used this technology to determine that IBDV replication factories display qualities of liquid-liquid phase separation 
 
Title IBDV Reverse Genetics System 
Description We have developed a reverse genetics system for IBDV. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact We have used the reverse genetics system to generate recombinant IBDVs and chimeric recombinant IBDVs that contain genes from classical and very virulent strains of IBDV in the background of a cell culture adapted attenuated strain. This will enable us to study the effect of individual virus genes on pathogenicity. 
 
Title Method for sequencing of ASFV (African Swine Fever Virus) based on long reads 
Description The ASFV genome is repetitive, due to the presence of families of genes that are present in multiple copies (>10). As a result, sequencing based on short reads only would not be able to reconstruct the genome in its entirety. In addition, good quality full genome sequencing of ASFV is complicated by persistence contamination with fragments of host DNA. We are developing a novel protocol that will allow the sequencing of the virus using long-read technologies (PacBio or Oxford Nanopore). Probe-capture libraries have been designed to mitigate the problem of host contamination by selectively purifying viral DNA from a wide range of different ASFV genotypes. Protocols are being developed to prepare high quality high molecular weight viral DNA from different sample types suitable for generating sequencing libraries for long-read sequencing. 
Type Of Material Technology assay or reagent 
Year Produced 2019 
Provided To Others? No  
Impact More than 100 samples from 18 different LMIC countries have been identified and collated for sequencing with the new protocol. They will be added to the web-portal for transboundary pathogens which is currently being developed thanks to BBSRC funding. 
 
Title Method to evenly load flowcells with multiple samples 
Description Pirbright has an Illumina NextSeq sequencing machine installed in containment. Given the large amount of sequencing reads produced by each run, multiple samples are usually multiplexed on the same flowcell. However, determining the correct concentrations needed to obtain the same amount of reads for each sample is a hard problem, and usually requires a number of expensive and material-consuming kits to be run prior to sequencing. We have developed a method that allows samples to be evenly multiplexed based only on Bioanalyzer data (we routinely run Bioanalyser on the samples anyway as a form of quality control). The method works well, and reliably across a wide range of sample concentrations and sequenced organisms. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact The method greatly increased the quality of our output, and drastically simplified our workflow by eliminating the external quantification steps that were previously required. 
 
Title Optimisation of chicken kidney cell culture preparation 
Description We have optimised the method of extracting kidneys and preparing chicken kidney (CK) cell cultures from chickens. CK cells are used for in vitro assays to study avian viruses, in particular infectious bronchitis virus. 
Type Of Material Cell line 
Year Produced 2017 
Provided To Others? No  
Impact This has increased the yield of viable cells and the quality of the cell cultures. We can now obtain the number of cells we require using fewer chicken kidneys, therefore requiring fewer chickens to be culled. This is an important development for the 3Rs. We hope to publish this method for others' information. 
 
Title Panel of ACE2 proteins for screening SARS-CoV-2 host range 
Description A biological library of ACE2 expression constructs representing receptors from 22 different human and animal species. 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact Establishment of surveillance tools to examine the potential reverse zoonotic spillover of SARS-CoV-2 into anima species 
 
Title Stable chicken cell lines overexpressing chicken IFITM1,2 and 3 
Description In collaboration with Mark Fife, we have produced chicken stable cell lines overexpressing chicken IFITM1,2, 3 and a mutant chicken IFITM3 lacking palmitoylation sites. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact These cell lines will be used to evaluate the effect of the IFITM proteins on the replication of different viruses, including IBDV. 
 
Title UniMMap- a pipeline for mapping RNAseq data over repetitive immune complexes. 
Description To exploit the abundance of available short read sequencing data we have developed a pipeline that uses mappability to accurately measure transcription over repetitive gene complexes. This methods uses known haplotypes to examine regions of uniqueness, and then the RNAseq data from the individual to train the method to be species or individual specific. This is particularly important over gene complexes that contain genes involved in the immune system, that are often highly similar in sequence but can have profoundly different functions. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact the immediate impact will be adding fine resolution data to livestock gene expression atlas projects lead by the FAANG consortium. Further impact will be arising as this method is published and we apply it to numerous existing datasets the are publically avaialable as well as generated at Pirbright and by our collaborators. 
 
Title Use of reverse genetics to develop PPR DIVA vaccines 
Description Reverse genetics technique has been established for PPR virus in our laboratory. As PPR vaccine is a live attenuated virus, it is not possible to differentiate between vaccinated and infected animals (DIVA) in existing antibody assays. However using reverse genetics technique we have manipulated/mutated residues in the full-length cDNA of virus and rescued the live attenuated vaccine strain which worked as a DIVA vaccine. Using this technique a GFP ( Green fluorescent protein) has been introduced into the virulent PPR virus that helped to follow the virus in the infected goats. Similarly using this technique we have modified the existing live attenuated viruses ( Nigeria 75/1) and Sungri 96/1) in to recombinant marker vaccines that enables to differentiate between infection and vaccination ( DIVA). So we have demonstrated that reverse genetics tool can be used to study the pathogenesis and to develop the marker vaccines. This technique can be adapted for other negative strand viruses to design the DIVA vaccines. 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact PPR DIVA vaccine developed that can differentiate between vaccinated and infected animals. This will be helpful to know the efficacy of vaccine by knowing the presence antibodies in animal is due to vaccination or infection. This will reduce the eradication time and will facilitate to declare freedom of diseases as soon as Possible without long waiting period. 
 
Title chimeric IBDVs 
Description Andrew Broadbent has engineered chimeric IBDVs expressing individual genes from a very virulent strain in the backbone of an attenuated strain. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact These chimeric strains can be used to define viral determinants of virulence. 
 
Title replication competent recombinant split-GFP infectious bursal disease virus 
Description We have generated a replication competent recombinant split-GFP infectious bursal disease virus (IBDV) where a small GFP11 molecule is tagged to the virus polymerase (VP1) to make IBDV-VP1-GFP11. Infected cells that express the GFP1-10 molecule fluoresce green when the GFP11 tag complements the GFP1-10. The IBDV-VP1-GFP11 colocalises with VP3 and dsRNA and therefore is likely to be present at the sites of virus replication. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact This tool can be used to study IBDV replication complex development in infected cells. 
 
Title tetracysteine-tagged IBDV 
Description Andrew Broadbent has engineered a tetracysteine (TC)-tagged IBDV that can be used in live cell imaging and co-infection studies with the split-GFP IBDV. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact This tool, combined with the split-GFP IBDV, will enable us to study co-infection, super-infection exclusion, and the intracellular requirements for viral reassortment. 
 
Title Analysis of paramyxovirus replication using Incucyte real-time imager 
Description We have optimised a data analysis pipeline for the Incucyte real-time imager to allow us to track viral replication in a high-throughput fashion (up to 6 x 96-well plates). This is based on simultaneous analysis of phase, as well as green and red fluorescence. 
Type Of Material Data analysis technique 
Year Produced 2018 
Provided To Others? No  
Impact Only preliminary data to date. 
 
Title Boosting the FM-index on the GPU 
Description The FM-index is a data structure that lies at the core of most modern short-read aligners. Our work describes what is perhaps the first implementation of the FM-index on the GPU able to take full advantage of the high hardware parallelism (large number of computing cores) offered by modern Graphical Processing Units. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? No  
Impact Short-read aligners are instrumental to the analysis of high-throughput sequencing experiments. As alignment is central to most analysis pipelines, speeding it up is essential to improve the performance of many bioinformatics tools. Thanks to our new algorithm FM-index based searches can be sped up by a large factor on all computers where a suitable GPU is present. 
 
Title Full length cattle MHC genes 
Description Using our method for full length MHC gene amplification, the largest reference set ever produced from common haplotypes has been sequenced and deposited in the publicly available data IPD-MHC with associated research tools. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? No  
Impact None yet, but it will allow far greater resolution when analysing MHC polymorphism and evolution in cattle populations. 
URL https://www.ebi.ac.uk/ipd/mhc/group/BoLA/
 
Title Method to detect the expression of repetitive genes 
Description Reconstructing expression levels of genes having a high repeat content is difficult, due to the impossibility of assigning RNA-sequencing that have multiple mappings to their correct originating location. In collaboration with the Immunogenetics group, the Integrative Biology and Bioinformatics groups are developing a data analysis method to circumvent the problem.The method has already been shown to be effective on some KIR genes in cattle. An essential component of the immune system, their family is rich in repeated members and repetitive regions, making the technique essential if one wants to study them. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact Being able to resolve the expression of repetitive genes, which are plentiful in most mammalian genomes, would be essential to the high-precision study of many important gene families, including most of the genes of the immune system. The technique has already proven itself effective on a real-life problem, and holds the potential to be extended to many more biological systems 
 
Title Supporting data for "De novo assembly of the cattle reference genome with single-molecule sequencing" 
Description Major advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10-12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated technologies and suffers from a variety of deficiencies and inaccuracies. We present the new reference genome for cattle, ARS-UCD1.2, based on the same animal as the original to facilitate transfer and interpretation of results obtained from the earlier version, but applying a combination of modern technologies in a de novo assembly to increase continuity, accuracy, and completeness. The assembly includes 2.7 Gb, and is >250x more continuous than the original assembly, with contig N50 >25 Mb and L50 of 32. We also greatly expanded supporting RNA-based data for annotation that identifies 30,396 total genes (21,039 protein coding). The new reference assembly is accessible in annotated form for public use. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
URL http://gigadb.org/dataset/100669
 
Title Viral assembly pipeline 
Description The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust viral assemblies out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, assembling of viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; uneven coverage due to low-quality material or the genomic material of the virus being RNA; the viral nucleic acid being almost lost in the background of nucleic acid of the host. Our pipeline overcomes most of those problems, and is even able to detect different viral strains being present together in the same sample. It can also be used on metagenomic environmental samples. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. 
 
Title Viral variant calling pipeline 
Description The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust variant calling for viral sequences out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, calling variant for viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; very high genome coverage, which slows down most existing variant callers; the presence of a potentially very high number of different haplotypes for RNA viruses, which is an unusual scenario in variant calling. Our fast and sensitive Bayesian pipeline overcomes most of those problems. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. 
 
Description ASFV Structure 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution We have prepared samples for analysis
Collaborator Contribution Electron tomographic analysis of the samples we provided.
Impact None as yet.
Start Year 2019
 
Description Anihwa Call 1 
Organisation Friedrich Loeffler Institute
Country Germany 
Sector Academic/University 
PI Contribution 1. Conducted challenge experiments in goats to study pathogenicity. 2. Developed NGS technology to sequence PPR whole genome.
Collaborator Contribution FLI has conducted transmission study between different species ( Goats, pig, camel). For the first time they showed that pigs are clinically infected by PPR virus.
Impact Joint Publications
Start Year 2013
 
Description Assembly of CHIKV in host cells/JEOL TEM training 
Organisation National Cheng Kung University
Country Taiwan, Province of China 
Sector Academic/University 
PI Contribution Visit to Tainan in May 2017, provided training in cellular imaging of virally infected cells. Gave a seminar entitled Bioimaging at The Pirbright Institute. Hosted two visitors for two weeks in Bioimaging at Pirbright, provided training in EM sample preparation and data interpretation.
Collaborator Contribution Professor Shang-Rung Wu hosted me for one week in Taiwan. During the visit to Pirbright, the Taiwanese researchers provided training on JEOL 2100F TEM to Pirbright researchers. Professor Wu provided prepared samples for imaging at a later date.
Impact No outputs yet
Start Year 2017
 
Description BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production.
Collaborator Contribution The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses.
Impact This project started in January 2020.
Start Year 2020
 
Description Belsham 
Organisation Technical University of Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Joint PhD studentship and ongoing collaboration on capsid assembly
Collaborator Contribution Joint PhD studentship and ongoing collaboration on capsid assembly
Impact Joint PhD studentship Further funding
Start Year 2016
 
Description Belsham 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Joint PhD studentship and ongoing collaboration on capsid assembly
Collaborator Contribution Joint PhD studentship and ongoing collaboration on capsid assembly
Impact Joint PhD studentship Further funding
Start Year 2016
 
Description Chicken Microbiome - Robert La Ragione - University of Surrey 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing sequencing data of gut microbiome from chickens infected with avian influenza viruses.
Collaborator Contribution Sharing expertise in the analysis of microbiome data
Impact Joint manuscripts and funding opportunities are being explored
Start Year 2019
 
Description Collaboration on replication of mumps virus in cells 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes
Collaborator Contribution Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM.
Impact No outcomes yet
Start Year 2018
 
Description Collaboration on the development of intranasal live-attenuated vaccine against SARS-CoV-2 
Organisation Lancaster University
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributed reagents to tests the immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2 in preclinical animal models including mice and hamster.
Collaborator Contribution The partners undertook most of the work to complete the study detailed in the publication entitled "Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2 in preclinical animal models". https://www.biorxiv.org/content/10.1101/2021.01.08.425974v1 Abstract of publication. The global deployment of an effective and safe vaccine is currently a public health priority to curtail the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a Newcastle disease virus (NDV)-based intranasal vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy in challenge studies with SARS-CoV-2. The recombinant (r)NDV-S vaccine expressing spike (S) protein of SARS-CoV-2 administrated via intranasal route in mice induced high levels of SARS-CoV-2-specific neutralizing immunoglobulin A (IgA) and IgG2a antibodies and T cell-mediated immunity. Hamsters vaccinated with two doses of vaccine showed complete protection from clinical disease including lung infection, inflammation, and pathological lesions after SARS-CoV-2 challenge. Importantly, a single or double dose of intranasal rNDV-S vaccine completely blocked SARS-CoV-2 shedding in nasal turbinate and lungs within 4 days of vaccine administration in hamsters. Taken together, intranasal administration of rNDV-S has the potential to control infection at the site of inoculation, which should prevent both the clinical disease and transmission to halt the spread of the COVID-19 pandemic.
Impact The partnership resulted in a joint publication. "Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2 in preclinical animal models". https://www.biorxiv.org/content/10.1101/2021.01.08.425974v1 Abstract of publication. The global deployment of an effective and safe vaccine is currently a public health priority to curtail the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a Newcastle disease virus (NDV)-based intranasal vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy in challenge studies with SARS-CoV-2. The recombinant (r)NDV-S vaccine expressing spike (S) protein of SARS-CoV-2 administrated via intranasal route in mice induced high levels of SARS-CoV-2-specific neutralizing immunoglobulin A (IgA) and IgG2a antibodies and T cell-mediated immunity. Hamsters vaccinated with two doses of vaccine showed complete protection from clinical disease including lung infection, inflammation, and pathological lesions after the SARS-CoV-2 challenge. Importantly, a single or double dose of intranasal rNDV-S vaccine completely blocked SARS-CoV-2 shedding in nasal turbinate and lungs within 4 days of vaccine administration in hamsters. Taken together, intranasal administration of rNDV-S has the potential to control infection at the site of inoculation, which should prevent both the clinical disease and transmission to halt the spread of the COVID-19 pandemic.
Start Year 2020
 
Description Collaboration with Bauchi State Veterinary Services, Nigeria 
Organisation Bauchi State University
Country Nigeria 
Sector Academic/University 
PI Contribution We have provided expertise on sheeppox, goatpox and lumpy skin disease virus diagnosis and epidemiology
Collaborator Contribution Our collaborators in Bauchi State have provided virus samples and epidemiological data
Impact Preliminary data was used to support successful funding via a BBSRC Impact Accelerator Award, and a Pathways to Impact project in BBSRC project BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines"
Start Year 2016
 
Description Collaboration with Keith Chappell on virus neutralisation 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution Assessment of neutralisation to a range of viral immunogens by VNT using pseudotyping technology
Collaborator Contribution Provision of sera from vaccination studies
Impact None yet, publications in preparation
Start Year 2020
 
Description Collaboration with Prof. Jane McKeating on SARS-CoV-2 virology 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Assessment of SARS-CoV-2 cell-cell fusion under various conditions, and with chemical inhibitors
Collaborator Contribution Provision of inhibitors and other reagents
Impact None yet, paper under review
Start Year 2020
 
Description Collaboration with State Central Veterinary Laboratory, Mongolia 
Organisation State Central Veterinary Laboratory
Country Mongolia 
Sector Public 
PI Contribution We provided tools, techniques and expertise on sheeppox and goatpox
Collaborator Contribution Our colleagues provided data and field samples
Impact A workshop was held in Pirbright in March 2017, and a return workshop in Ulaanbaatar in July 2017. Preliminary data supported successful grant applications for an Impact Accelerator Award, and a Pathways to Impact project in BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines".
Start Year 2016
 
Description Collaboration with University of Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed in vitro experiments with infectious bronchitis virus, contributed to data analysis, preparation of manuscripts and discussed further funding opportunities.
Collaborator Contribution Our partners have analysed viral transcription and translation, and host gene expression after infection of host cells with infectious bronchitis virus, prepared manuscripts and discussed further funding opportunities.
Impact Dinan, A., Keep, S., Bickerton, E., Britton, P., Firth, A. and Brierley, I. (2019) Comparative analysis of gene expression in virulent and attenuated strains of infectious bronchitis virus at sub-codon resolution. J. Virol. 93(18) e00714-19.
Start Year 2012
 
Description Collaboration with University of Copenhagen CFIM on cell biology of virus-host interactions 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Intellectual input into virus projects which come in to the microscopy core facility at the University. Limited practical work and training given to researchers there. Includes lecturing/organisation of MSc and PhD courses at Copenhagen. PH awarded Visiting Professorship.
Collaborator Contribution Research projects are presented to the core facility, I advise on the best route for achieving the data required and those researchers complete preliminary data following my advice. Collaborators are then able to produce the best possible samples for further advanced microscopy as necessary.
Impact No tangible outcomes yet as we are in early stages. This is multi-disciplinary as projects can come from several University departments (medical, pathology, cell biology, veterinary, food), and other Universities in Denmark (DTU). University awarded Visiting Professorship
Start Year 2018
 
Description Collaborative PhD student project on virus-bacteria-host-vector interaction 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a collaborative PhD studentship funded by The Pirbright Institute between Pirbright and the Roslin Institute. The student is investigating how bacteria or bacterial compounds will effect bluetongue virus replication in mammalian host cells with a specific emphasis on skin derived migratory cells. While mainly based at Pirbright the student will visit the Roslin Institute and spend some time in the lab of Prof. Jane Hope.
Collaborator Contribution The student will carry out the main laboratory work at Pirbright including infection studies of ruminant primary host target cells in the presence/ absence of bacterial compounds. There will be regular meetings between the students and supervisors at Pirbright and at Roslin (at least monthly by skype) and the student will visit the Roslin group for specific work aspects such as flow cytometry of skin derived pseudo-afferent lymph cells. Roslin will also make cattle pseudo-afferent lymph cells available to the student and Pirbright for ex vivo BTV infection studies.
Impact bacteriology, virology, immunology, virus-host interaction
Start Year 2019
 
Description Collaborative network with Ed Wright, Nigel Temperton and Giada Mattiuzzo on SARS-CoV-2 pseudotyping 
Organisation National Institute for Biological Standards and Control (NIBSC)
Country United Kingdom 
Sector Public 
PI Contribution Development and establishment of SARS-CoV-2 research tools, including pseudotypes and cell-cell fusion assays
Collaborator Contribution Provision of reagents, protocols and technical guidance
Impact We aided in NIBSC's development of WHO international standard for SARS-CoV-2
Start Year 2020
 
Description Collaborative network with Ed Wright, Nigel Temperton and Giada Mattiuzzo on SARS-CoV-2 pseudotyping 
Organisation University of Kent
Country United Kingdom 
Sector Academic/University 
PI Contribution Development and establishment of SARS-CoV-2 research tools, including pseudotypes and cell-cell fusion assays
Collaborator Contribution Provision of reagents, protocols and technical guidance
Impact We aided in NIBSC's development of WHO international standard for SARS-CoV-2
Start Year 2020
 
Description Collaborative network with Ed Wright, Nigel Temperton and Giada Mattiuzzo on SARS-CoV-2 pseudotyping 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Development and establishment of SARS-CoV-2 research tools, including pseudotypes and cell-cell fusion assays
Collaborator Contribution Provision of reagents, protocols and technical guidance
Impact We aided in NIBSC's development of WHO international standard for SARS-CoV-2
Start Year 2020
 
Description Collaborative project between The Pirbright Institute, UK and Miyazaki University, Japan 
Organisation University of Miyazaki
Country Japan 
Sector Academic/University 
PI Contribution Provision of expertise in foot-and-mouth virus research; use of high containment facilities to perform experiments
Collaborator Contribution Expertise in tetramer production, analysis and provided financially towards a travel bursary.
Impact The protection afforded by most foot-and-mouth disease (FMD) vaccines depends to a large extent on humoral immunity, dictating the need to characterise the underlying mechanisms that mediate antibody production. To address this, we have developed novel major histocompatibility complex (pMHC) class II tetramers to identify antigen specific CD4+ T-cells that are present following vaccination against FMD. To date, we have used a MHC II tetramer (MHC serotype: A18) and peripheral blood mononuclear cells (PBMCs) from MHC-matched cattle vaccinated against FMD (O serotype). Importantly, we have identified CD4+ T-cells that recognise 15 epitopes (identified from 137 peptides) in the FMDV structural proteins; one in VP1, five in VP2, six in VP3 and three in VP4. This work will further our understanding of the repertoire of capsid epitopes recognised by the host's immune response following FMD vaccination and facilitate the identification of new correlates of protection. A first manuscript is in the final stages of preparation and will be submitted shortly.
Start Year 2017
 
Description Collaborative studentship PPRV 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Practical laboratory work and in vivo animal studies carried out
Collaborator Contribution Intellectual input in scientific remit of studentship, training of student, use of facilities and lab
Impact DOI: 10.1128/JVI.01471-18 Thesis: The immune response to live, attenuated peste des petits ruminants virus vaccines
Start Year 2014
 
Description Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution I develop a research project proposal in which we are investigating how evolutionary changes in the H9N2 avian influenza virus modulate virus fitness and virulence in chickens. This PhD studentship project was funded by Commonwealth scholarship commission for 3 years.
Collaborator Contribution The collaborating Partner Dr Nicola Lewis at Royal Veterinary College is a co-supervisor of the PhD student Thusitha Karunarathna. she provide necessary guidance to achieve prescribed objectives of this project.
Impact The project is at its initial stage.
Start Year 2019
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti 
Organisation National Health Research Institutes (NHRI) Taiwan
Department Institute of Molecular and Genomic Medicine
Country Taiwan, Province of China 
Sector Charity/Non Profit 
PI Contribution Developed joined research project and lead successful application for funding
Collaborator Contribution Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress.
Impact No impact yet.
Start Year 2018
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti 
Organisation National Institute of Genetics
Department NIG-FLY, Mishima (Drosophila RNAi resources)
Country Japan 
Sector Academic/University 
PI Contribution Developed joined research project and lead successful application for funding
Collaborator Contribution Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress.
Impact No impact yet.
Start Year 2018
 
Description Development of a bivalent PRRS/Nipah virus vaccine 
Organisation National Center for Genetic Engineering and Biotechnology (BIOTEC)
Country Thailand 
Sector Public 
PI Contribution Expertise in PRRSV and Nipah virus vaccine research
Collaborator Contribution Expertise in genetically engineering PRRSV
Impact Too early.
Start Year 2020
 
Description Dr Carol Cardona, University of Minnesota- avian influenza virus challenge of IBDV or mock-infected chickens 
Organisation University of Minnesota
Country United States 
Sector Academic/University 
PI Contribution We will challenge birds that have been exposed to IBDV, or mock exposed, with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens.
Collaborator Contribution Dr Cardona's group will challenge birds that have been exposed to IBDV, or mock exposed, with low pathogenic avian influenza (LPAI) strains to determine how IBDV-mediated immunosuppression impacts upon LPAI infection in chickens.
Impact we have been successful in obtaining funding (Grant Ref: BB/T008806/1)
Start Year 2019
 
Description Dr Holly Shelton, The Pirbright Institute- avian influenza virus challenge of IBDV or mock-infected chickens 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We will expose birds to IBDV, compared to mock controls
Collaborator Contribution Holly will train my group in conducting studies with avian influenza viruses and, together, we will challenge birds with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens.
Impact we have been successful in obtaining funding (Grant Ref: BB/T008806/1)
Start Year 2019
 
Description Dr Liam Morrison 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis is single cattle B cell antibody sequences
Collaborator Contribution Single cattle B cell antibody sequences
Impact None as yet
Start Year 2019
 
Description Dr Lyndsay Fry 
Organisation Washington State University
Department Washington State University Spokane
Country United States 
Sector Academic/University 
PI Contribution Single B cell sorting and antibody sequencing, developing a new methods for Theileria sp.
Collaborator Contribution Providing funding and the samples from immunised animals. We have also engineered an antibody to aid in the sorting of cattle B cells
Impact None as yet
Start Year 2019
 
Description Dr Michael Skinner, Imperial College London 
Organisation Imperial College London
Department Department of Primary Care and Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We aim to compare the host transcriptional response of primary chicken B cells infected with different strains of IBDV of varying virulence. We have the specialist reagents and expertise in house that are required to culture primary chicken B cells, and we have access to different strains of IBDV.
Collaborator Contribution Dr Michael Skinner and his team at Imperial College London have the expertise and facilities to generate and analyse RNA-Seq data in order to determine host transcriptional responses. This is required in order to complete the aim of the project.
Impact Further funding: PhD studentship (£102,800) - Dr Andrew Broadbent at The Pirbright Institute and Dr Michael Skinner at Imperial College London are joint supervisors for a PhD student working on this project. Further Funding: Houghton Trust (£8,000)- Dr Andrew Broadbent was awarded a Houghton Trust Small Research Grant to contribute to this project. Further funding: NC3Rs (Grant Ref: NC/R001138/1)
Start Year 2014
 
Description Dundee 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-INvestigator on BBSRC sLoLa award
Collaborator Contribution Co-INvestigator on BBSRC sLoLa award
Impact BBSRC sLoLa award ongoing
Start Year 2012
 
Description Edinburgh - Haas 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-Investigator on BBSRC sLoLa award Co-Investigator on BBSRC project grant Collaboration in virus-host interactions
Collaborator Contribution Co-Investigator on BBSRC sLoLa award Co-Investigator on BBSRC project grant Collaboration in virus-host interactions
Impact BBSRC sLoLa award BBSRC project grant
Start Year 2012
 
Description Evaluation of COVID-19 vaccine candidate immunogenicity in pigs 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in evaluating vaccine immunogenicity in pigs
Collaborator Contribution Provided COVID-19 vaccine candidates
Impact Joint publication on the evaluation of ChAdOx1 nCoV-19 (AZD1222) (https://doi.org/10.1038/s41541-020-00221-3). Data included in in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application.
Start Year 2020
 
Description Evaluation of COVID-19 vaccine candidate immunogenicity in pigs 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in evaluating vaccine immunogenicity in pigs
Collaborator Contribution Provided COVID-19 vaccine candidates
Impact Joint publication on the evaluation of ChAdOx1 nCoV-19 (AZD1222) (https://doi.org/10.1038/s41541-020-00221-3). Data included in in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application.
Start Year 2020
 
Description Evaluation of a PRRSV-vectored Nipah virus vaccine 
Organisation National Center for Genetic Engineering and Biotechnology (BIOTEC)
Country Thailand 
Sector Public 
PI Contribution Expertise in porcine immunology/vaccinology, inc. PRRSV and Nipah
Collaborator Contribution Expertise in PRRSV reverse genetics
Impact None as yet
Start Year 2019
 
Description Evaluation of bovine herpesvirus-4 as a vaccine vector for pigs 
Organisation University of Parma
Country Italy 
Sector Academic/University 
PI Contribution Expertise in porcine vaccinology/immunology
Collaborator Contribution Expertise in the generation of recombinant bovine herpesvirus-4 (BoHV-4) vectors expressing heterologous antigens
Impact We demonstrated that immunisation of pigs with recombinant BoHV-4 vectors expressing Nipah virus glycoproteins are highly immunogenic in pigs. Most promising and as hypothesised, were the potent CD4 and CD8 T cell responses which were an order of greater than those induced by other viral vaccine vectors. These data have led to the external funding of projects by two companies to evaluate BoHV-4 vectors in the context of other porcine diseases.
Start Year 2018
 
Description Evaluation of immune checkpoint inhibitors as molecular adjuvants for improved PRRSV vaccines 
Organisation Leidos
Country United States 
Sector Private 
PI Contribution Expertise in PRRSV immunology
Collaborator Contribution Patented immune checkpoint inhibitors
Impact No yet
Start Year 2019
 
Description Evaluation of mRNA vectored vaccines in pigs 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution Expertise in porcine immunology/vaccinology
Collaborator Contribution Expertise in mRNA vaccines
Impact We evaluated in pigs the immunogenicity an mRNA vector encoding a Nipah virus glycoprotein. This vaccine formulation induced high virus neutralising antibody titres (comparable with protein subunit in adjuvant) and T cell responses (comparable with viral vectors). We also utilised mRNA immunised pigs to isolate Nipah virus neutralising monoclonal antibodies.
Start Year 2018
 
Description Evaluation of solid dose vaccines for livestock 
Organisation Enesi Pharma
Country United Kingdom 
Sector Private 
PI Contribution Expertise in PRRSV and vaccine evaluation
Collaborator Contribution Expertise in vaccine formulation
Impact Multidisciplinary collaboration between formulation scientist and viral immunologists.
Start Year 2019
 
Description Genetic analysis orbiviruses 
Organisation University of Surrey
Department Faculty of Health and Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Virus sequences provided for analysis. Meeting and discussion for analysis by virologist employed on this project and biomathematican at the University of Surrey
Collaborator Contribution Analysis of data, training of the virologist and computational and mathematical methodology, discussion about analysis strategies
Impact The collaboration is multi-disciplinary - between mathematical modelling and virology. Data analysis is still ongoing but is envisaged as preliminary data for future funding applications
Start Year 2017
 
Description HMS 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Collaboration
Collaborator Contribution Collaboration
Impact Collaborative research
 
Description High containment microscopy with Thermo Fisher 
Organisation Thermo Fisher Scientific
Country United States 
Sector Private 
PI Contribution Provide advice on decontamination protocols
Collaborator Contribution Development/optimisation of microscope decontamination procedures
Impact No outputs yet, very early stages of collaboration
Start Year 2019
 
Description Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Collaborator Contribution My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Impact Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017.
Start Year 2017
 
Description Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. 
Organisation University of Kent
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Collaborator Contribution My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments.
Impact Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017.
Start Year 2017
 
Description Identification of sows with antibodies broadly neutralising PRRSV 
Organisation University of Lleida
Country Spain 
Sector Academic/University 
PI Contribution Expertise in PRRSV immunology
Collaborator Contribution Access to large numbers of sows routinely vaccinated and exposed to PRRSV
Impact Not yet
Start Year 2019
 
Description Imperial 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint supervision of PhD student
Collaborator Contribution Joint supervision of PhD student
Impact One successful completed PhD student. Papers published or in preparation. Another PhD student in progress.
Start Year 2010
 
Description Industrial partnership-Aviagen 2018 
Organisation Aviagen Group
Country United States 
Sector Private 
PI Contribution We have established a significant industrial partnership with Aviagen group Ltd. The nature of this work remains confidential.
Collaborator Contribution The nature of this work remains confidential.
Impact The nature of this work remains confidential.
Start Year 2018
 
Description Interferon stimulated genes 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Hosted meetings and carried out preliminary experiments
Collaborator Contribution Contributed reagents and expertise
Impact Preliminary data was used to support an MSc project. This has since led to a publication and a PhD project.
Start Year 2016
 
Description Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses 
Organisation Royal Veterinary College (RVC)
Department Veterinary Basic Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy.
Collaborator Contribution provided intellectual input for achieving prescribed objectives of this work.
Impact Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019.
Start Year 2019
 
Description Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses. 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution We developed research programme to characterise diversity of antigenic epitopes induce protective immunity in chickens against H5 subtypes of avian influenza viruses.
Collaborator Contribution Collaborating partner Dr Nicola Lewis at Royal Veterinary College provide advise to on cartography programme to visualize the antigenic similarity or difference among different strains of influenza viruses.
Impact The work under this collaborative determined the antigenic differences among different clades of H5 avian influenza viruses circulating in birds. This project is multi-disciplinary. our laboratory mainly work on virology and immunology part of the project and we seek help on computer modeling part from the collaborating partner Dr Nicola Lewis.
Start Year 2019
 
Description Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 
Organisation Chinese Academy of Agricultural Sciences
Department Shanghai Veterinary Research Institute
Country China 
Sector Public 
PI Contribution Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector
Collaborator Contribution Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/).
Impact organised joint meeting in China and the UK to discuss on challenges and opportunities
Start Year 2017
 
Description JN - Preparation of capped mesoporpus silica nanoparticles 
Organisation Polytechnic University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments
Collaborator Contribution Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments.
Impact Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples
Start Year 2016
 
Description JS - Production of monoclonal antibodies that recognise FMDV VP4 from mouse spleens 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution VLPs displaying the N-terminal 15 amino acids of FMDV were designed and produced at The Pirbright Institute and then mice were immunised with them. The spleens of the immunised mice were harvested and splenocytes stored. The response to the VP4 sequence was checked by ELISA and the mouse with the best response was selected to send the splenocytes for monoclonal production.
Collaborator Contribution The collaborators took the splenocytes obtained from the mouse experiments and carried out the fusions. They then screened the supernatants for positive wells that detected the VP4 sequence.
Impact Positive wells have been identified indicating some monoclonals that are specific for VP4 have been generated. These will be further screened for ability to recognise virus and to neutralise infection.
Start Year 2017
 
Description LMB 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration
Collaborator Contribution Collaboration
Impact Collaborative research
Start Year 2016
 
Description Leeds FBS 
Organisation University of Leeds
Department Leeds Institute of Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Research
Collaborator Contribution Research and student supervision
Impact Research
Start Year 2009
 
Description Linking sex determination and dosage compensation in a mosquito Anopheles gambiae 
Organisation University of Zurich
Department Institute of Molecular Life Sciences
Country Switzerland 
Sector Academic/University 
PI Contribution Developed a new research program.
Collaborator Contribution Provided intellectual input, contributed to drafting a joined grant proposal.
Impact No output yet.
Start Year 2019
 
Description Merial 
Organisation Sanofi
Department Merial Plc
Country Global 
Sector Private 
PI Contribution BBSRC Link award
Collaborator Contribution BBSRC Link award
Impact BBSRC Link award in progress
Start Year 2016
 
Description Next-generation PRRSV vaccines 
Organisation Eco Animal Health Ltd
Country United Kingdom 
Sector Private 
PI Contribution Know how in terms of genetically manipulating PRRSV and evaluating PRRSV vaccines.
Collaborator Contribution Financial contribution and know how in terms of developing a commercial vaccine.
Impact Too early.
Start Year 2020
 
Description Next-generation PRRSV vaccines 
Organisation Huvepharma
Country Bulgaria 
Sector Private 
PI Contribution Expertise in PRRSV virology and immunology
Collaborator Contribution Funding
Impact Too early, project ongoing.
Start Year 2019
 
Description Nicolas Locker - Investigation of translation regulation by infectious bronchitis virus 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution My team provide experience in molecular virology and cellular interactions of infectious bronchitis virus including previous experience of IBV accessory proteins regulating cellular translation. A PhD student works jointly between our labs.
Collaborator Contribution Dr Locker's team provide expertise in viral regulation of cellular translation and stress granule signalling. Dr Locker is also providing protocols, advice and training for techniques including ribopuromycylation and ribosome profiling. A PhD studentworks jointly between our labs.
Impact PhD student funding (studentship commenced Oct 2017) - Control of host cell translation by infectious bronchitis virus
Start Year 2016
 
Description Novel PRRS and swine influenza vaccines 
Organisation National Center for Genetic Engineering and Biotechnology (BIOTEC)
Country Thailand 
Sector Public 
PI Contribution Expertise in PRRS immunology and vaccine evaluation.
Collaborator Contribution Novel vaccine strains and SE Asian field strains
Impact Collaborative grant proposal funded under the BBSRC Newton Fund UK-China-Philippines-Thailand Swine and Poultry Research Initiative
Start Year 2017
 
Description Oxford - Strubi 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on virus structural biology and joint PhD studentship
Collaborator Contribution Collaboration on virus structural biology and joint PhD studentship
Impact Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging
Start Year 2008
 
Description PRRS and Influenza co-nfection studies 
Organisation Government of Thailand
Department National Science and Technology Development Agency (NSTDA)
Country Thailand 
Sector Public 
PI Contribution The Pirbright team of 4 scientists with expertise in immunology and animal care visited Thailand in July 2018 to train Thai colleagues to perform animal experiments (Chiang Mai) and analyse immune responses by ELISPOT and Flow cytometry (Bangkok). This provided Thailand with trained personnel and expertise in testing vaccines in pigs. As a result of the joint work, the Chiang Mai animal facility is currently being renovated. Development of such an animal facility will promote the production and testing of more vaccines by Thai scientists.
Collaborator Contribution Our Thai colleagues provided us with local Thai PRRS and Influenza virus strains which we use in our co-infection studies.
Impact None yet
Start Year 2018
 
Description Partnering with National Taiwan University 
Organisation National Taiwan University
Country Taiwan, Province of China 
Sector Academic/University 
PI Contribution We have prepared and submitted an application for a BBSRC-Taiwan Partnering Award to study "Assembly of Recombinant Infectious Bronchitis Virus and Determination of Antigenic Sites that Confer Hemagglutination Activity".
Collaborator Contribution The partners conceived the project and got in contact about submitting an application for funding together.
Impact An application has been made for a BBSRC-Taiwan Partnering Award in November 2018.
Start Year 2018
 
Description Prof. Subrayal Reddy 
Organisation Lancaster University
Country United Kingdom 
Sector Academic/University 
PI Contribution Electron microscopy of nano particles
Collaborator Contribution Provided the nano particles
Impact Papers have been published
Start Year 2019
 
Description Professor Helen Sang,The Roslin Institute - GFP1-10 expressing transgenic chickens 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We have developed IBDV tagged to GFP11
Collaborator Contribution Helen Sang's group at the Roslin Institute have developed transcgenic chicken lines that constitutively express GFP1-10 in every cell.
Impact we have been successful in obtaining funding (Grant Ref: BB/S014594/1)
Start Year 2019
 
Description Protein Production UK (Formerly the Oxford Protein Production Facility) 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution We are providing the sequences of antibodies from various species to add into the vectors at Oxford to produce species specific antibodies. We are also providing and devloping assays to measure recombinant antibody confirmation and binding.
Collaborator Contribution PPUK is providing access to all their facilities as well as expertise. They are alaso providing there vector backbone as the template for antibody production
Impact None as yet
Start Year 2018
 
Description RMS Training Focussed Interest Group 
Organisation The Royal Microscopical Society
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Expertise towards shaping the standards of UK microscopy training.
Collaborator Contribution Reviewing and maintaining microscopy training across the UK.
Impact Maintaining and improving training standards across the UK for microscopy.
Start Year 2015
 
Description Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies.
Collaborator Contribution this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains.
Impact The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health.
Start Year 2018
 
Description Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies.
Collaborator Contribution this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains.
Impact The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health.
Start Year 2018
 
Description Reannotation of the Anopheles gambiae genome 
Organisation Biomathematics and Statistics Scotland (BioSS)
Country United Kingdom 
Sector Public 
PI Contribution Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development.
Collaborator Contribution Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data.
Impact No outputs yet
Start Year 2017
 
Description Reannotation of the Anopheles gambiae genome 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development.
Collaborator Contribution Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data.
Impact No outputs yet
Start Year 2017
 
Description Reannotation of the Anopheles gambiae genome 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development.
Collaborator Contribution Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data.
Impact No outputs yet
Start Year 2017
 
Description Reporter PRRS viruses 
Organisation Kansas State University
Country United States 
Sector Academic/University 
PI Contribution A new application for recombinant reporter PRRS viruses i.e. to use them as a high throughput screen for neutralizing (monoclonal) antibodies. Use as tools to assess the tropism of PRRSV for dendritic cell subsets and the functional consequences.
Collaborator Contribution Provision of plasmids encoding GFP-expressing PRRSV-1 and -2.
Impact Not yet
Start Year 2016
 
Description Retroviral-mediated genetic programming of porcine memory B cells 
Organisation AIMM Therapeutics
Country Netherlands 
Sector Private 
PI Contribution Provided a novel 'model' system to test their technology to isolate novel monoclonal antibodies
Collaborator Contribution To provide their patented platform technology to genetically program porcine memory B cells to enable the isolation of memory B cells
Impact Not yet
Start Year 2016
 
Description SiSaf Ltd, FMDV + carriers 
Organisation SiSaf Ltd
Country United Kingdom 
Sector Private 
PI Contribution Advice on experimental design, provision of FMDV empty capsids (Alison Burman). Will do practical work in the future.
Collaborator Contribution Preparation of carrier formulations
Impact No outputs. Company did not respond to proposed experimental plan.
Start Year 2019
 
Description St Andrews 
Organisation University of St Andrews
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-investigator on BBSRC sLoLa
Collaborator Contribution Lead-investigator on BBSRC sLoLa
Impact BBSRC sLoLa ongoing
Start Year 2012
 
Description Supply of Arthropods to External Partners 
Organisation APS Biocontrol
Country United Kingdom 
Sector Private 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Animal and Plant Health Agency
Country United Kingdom 
Sector Public 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Animal and Plant Health Agency
Country United Kingdom 
Sector Public 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Bern University of Applied Sciences
Country Switzerland 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Charles University
Country Czech Republic 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation ETH Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Friedrich Loeffler Institute
Country Germany 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Helmholtz Association of German Research Centres
Department Helmholtz Centre for Environmental Research - UFZ
Country Germany 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Lancaster University
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Lancaster University
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Liverpool John Moores University
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Queen's University Belfast
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Rothamsted Research
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Swedish University of Agricultural Sciences
Country Sweden 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Texas A&M University-Central Texas
Country United States 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Greenwich
Department Natural Resources Institute Greenwich
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Greenwich
Department Natural Resources Institute Greenwich
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation University of Liverpool
Department School of Veterinary Science Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Lyon
Country France 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Reading
Department School of Biological Sciences Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation University of Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of St Andrews
Country United Kingdom 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Veterinary Medicine Hanover
Country Germany 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation University of Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation VUC Aarhus
Country Denmark 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Wageningen University & Research
Country Netherlands 
Sector Academic/University 
PI Contribution A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department.
Collaborator Contribution A range of scientific studies around biting midges and mosquitoes. For outputs see publications.
Impact Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations.
Start Year 2011
 
Description Supply of Arthropods to External Partners 
Organisation Wageningen University & Research
Country Netherlands 
Sector Academic/University 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Supply of Arthropods to External Partners 
Organisation Zoological Society of London
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany).
Collaborator Contribution Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies.
Impact Products are still in development.
Start Year 2017
 
Description Syngenta UK 
Organisation Syngenta International AG
Department Syngenta Ltd (Bracknell)
Country United Kingdom 
Sector Private 
PI Contribution This collaboration aims to identify functional relationships between insecticide resistances in mosquitoes and competence of vector mosquitoes for arboviruses. Further, this collaboration aims at the generation of transgenic mosquitoes overexpressing proteins involved in certain insecticide resistances as tools to study the mechanism for such resistances. We have selected candidate proteins and overexpressed them in cell culture and in mosquitoes for vector competence studies as well as functional studies (insecticide uptake bioassays).
Collaborator Contribution Syngenta UK has provided intellectual input into our study design and expertise in the field of insecticide resistance mechanisms.
Impact No outputs yet. Collaboration between The Pirbright Institute and agrochemical industry.
Start Year 2019
 
Description The GCRF One Health Poultry Hub 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia.
Collaborator Contribution Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use.
Impact Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production.
Start Year 2018
 
Description The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV).
Collaborator Contribution This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world.
Impact Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020).
Start Year 2020
 
Description Thomas Bowden - STRUBI - University of Oxford - Glycoprotein structure collaboration 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of data and advice about the biological properties of viral glycoproteins, e.g. their fusion capacity with various receptors, their role in determining host-range
Collaborator Contribution Advice and technical support at the structural level supporting future project development and design
Impact No outcomes as yet
Start Year 2018
 
Description Trevor Sweeney - University of Cambridge PhD Studentship 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of PhD studentship project in collaboration with Dr. Sweeney's lab at Cambridge and application at Pirbright.
Collaborator Contribution Development of PhD studentship project and application at Cambridge.
Impact The PhD studentship has been funded and is currently been advertised.
Start Year 2018
 
Description University of Liverpool Proteomics Collaboration 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Generation of samples to analyse the membranous proteome of cells infected with paramyxoviruses.
Collaborator Contribution Proteomic analysis of samples and technical support. Access to previous data-sets and expertise.
Impact Preliminary data sets only to date.
Start Year 2018
 
Description Use of fluorescent virions to isolate PRRSV-specific porcine B cells 
Organisation University of Minnesota
Country United States 
Sector Academic/University 
PI Contribution Deployment of a novel technology to facilitate isolation of PRRSV neutralizing monoclonal antibodies
Collaborator Contribution Provision of a method to fluorescently tag purified virions to label PRRSV-specific B cells
Impact None to report to date
Start Year 2016
 
Description Wilhelm Gerner 
Organisation University of Veterinary Medicine Vienna
Country Austria 
Sector Academic/University 
PI Contribution Our lab hosted Dr Gerner who brought samples for RNA-seq. My lab planned and executed the sequencing and is contributing to the analysis.
Collaborator Contribution Dr Gerner did all the animal work and cell sorting to produce the samples reading for RNA-seq
Impact None as yet, analysis is ongoing
Start Year 2019
 
Description York 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration
Collaborator Contribution Collaboration
Impact Collaboration
Start Year 2015
 
Title Chicken IFITMs 
Description The present invention provides an avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3). 
IP Reference WO2014195692 
Protection Patent granted
Year Protection Granted 2018
Licensed Commercial In Confidence
Impact The present invention provides an avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3). This patent has enabled us to leverage funding for continued work.
 
Title PPR DIVA vaccine 
Description We ahve developed two PPR live attenuated DIVA vaccines that can differentiate between vaccinated and infected animals. 
IP Reference PCT/GB2019/053641,WO2020128496 
Protection Patent application published
Year Protection Granted 2020
Licensed Commercial In Confidence
Impact Till date there is no PPR vaccine avalable that can differentiate between vaccination and infection. This causes a huge issue on eradication of the didease and declare freedom from the disease. Therefore our newly develped chimeric live attenauted PPR vaccine and DIVA tests can differentiate between vaccination and infection which is a great achievement for ongoing PPR eradication. Please see detail from the below web. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020128496
 
Title CARGO: effective format-free compressed storage of genomic information 
Description CARGO is a compressor compiler. Given a high-level description of a file format (such as FASTQ or SAM) and compression methods for each field, it automatically generates optimized (de)compressors for such a format. Random access and range queries are provided for sorted datasets. Arbitrary sets of CARGO-compressed files can be stored together in a CARGO container. 
Type Of Technology Software 
Year Produced 2016 
Impact Technical solutions derived from CARGO are being discussed for incorporation into the upcoming MPEG (Moving Picture Experts Group) standard for the compression of genomic information 
 
Description Poster presentation: International Pig Veterinary Symposium and International PRRS Symposium, Chongqing, PR China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Luke Johnson (PhD student) gave a poster presentation on his studies on the interaction of macrophages and dendritic cells with PRRSV of differing virulence.
Year(s) Of Engagement Activity 2018
 
Description Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference discussed improving prevention and control of viral diseases of poultry.
Year(s) Of Engagement Activity 2018
 
Description "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference discussed prevention and control of infectious diseases affecting poultry production.
Year(s) Of Engagement Activity 2018
 
Description "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections.
Year(s) Of Engagement Activity 2018
 
Description 1st Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on "Generic approach for the development of genetic sexing strains for SIT applications" Vienna, 7-11 October 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FAO/IAEA Coordinated Research Project on exploring genetic and molecular methods of sex separation in insect pests; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field.
Year(s) Of Engagement Activity 2019
 
Description 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry.
Year(s) Of Engagement Activity 2018
 
Description 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities.
Year(s) Of Engagement Activity 2017
URL http://www.labanimaltour.org/pirbright
 
Description A talk at a symposium entitled: Using the 3Rs to support good science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I gave a talk at a Symposium held at The Pirbright Institute entitled: "Using the 3Rs to support good science". The talk was entitled: "A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry"
Year(s) Of Engagement Activity 2017
 
Description A talk at the British Poultry Diseases Group meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The Poultry Diseases Group meet quarterly and is comprised of representatives from private veterinary practices, vaccine and pharmaceutical industries, and the Animal and Plant Health Agency (APHA). I gave a talk at one of the meetings outlining my research to date and future directions.
Year(s) Of Engagement Activity 2017
 
Description AHSV talk on transmission for OIE (Thailand online) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on transmission of AHSV to interested parties following outbreak in 2020. Talk given on 9/6/20 to approx 150.
Year(s) Of Engagement Activity 2020
 
Description AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock.
Year(s) Of Engagement Activity 2020
URL https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro...
 
Description Amin Asfor presented the findigs of the project at the Microbiology Society Annual meeting, 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Amin Asfor presented the findigs of the project at the Microbiology Society Annual meeting, 2019. Title: in vivo and ex vivo models of Infectious Bursal Disease Virus (IBDV) in inbred chicken lines differing in their resistance to the disease.
Year(s) Of Engagement Activity 2019
 
Description Amin Asfor presented the work at the NC3Rs Fellows Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Amin Asfor presented a poster at the NC3Rs Fellows Day entitled: Chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry
Year(s) Of Engagement Activity 2019
 
Description Ash Manor GCSE Mentoring 2018 - BA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Avian influenza viruses can combine two techniques to evade vaccine immunity 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A study by researchers at The Pirbright Institute reveals more clues about how avian influenza viruses can evade vaccine immunity, aiding their spread in the field. The findings are published in Emerging Microbes and Infections.

Influenza viruses are able to mutate, which can enable them to evade immunity generated by natural infection or vaccination. Influenza viruses have four main ways of duping the immune system so that they can continue to infect and spread between birds. Pirbright scientists investigated two of these to further understand how the H9N2 avian influenza virus can change its genetic makeup to overcome poultry vaccines.

One of the methods the virus can use is to alter one of its surface proteins, haemagglutinin (HA), which enables the virus to enter the cell and replicate. HA is also a common target for the immune system's antibodies, which block the virus from binding to cell receptors. By changing just one or two protein components, HA can latch on far more tightly to the cell, preventing antibodies from stopping the virus. However, this can come at a cost, as particularly strong binding can prevent effective replication.

The other method scientists investigated is how H9N2 viruses disguise themselves by adding sugar chains to the surface of their HA proteins. This can block antibodies from binding, but also has varying fitness outcomes for the influenza virus. The researchers found that the location of the sugar chain on HA could determine how effectively the virus replicated.

They also demonstrated that the two evasive techniques could either compliment or act against each other - if an influenza virus had gained mutations that enable it to bind more strongly to cells, a sugar chain in the right position could restore its ability to replicate effectively. In contrast, weakly binding influenza viruses do not benefit from HA sugar additions, which instead reduce the virus's ability to replicate.

Professor Munir Iqbal, head of the Avian Influenza Group at Pirbright said, "We can use this knowledge to develop new vaccines that will help antibodies to recognise how the flu virus can change. This will provide protection to birds even as the virus evolves. We can also use this information to understand how viruses survive in poultry despite vaccination and monitor new adaptions that may appear in the field."

This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI) and the British Council with support from the Newton Fund.

Article: Sealy, J. E., Peacock, T. P., Sadeyen, J. R., Chang, P., Everest, H. J., Bhat, S., Iqbal, M. (2020). Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness. Emerging Microbes & Infections, advance online publication, 12 November 2020, doi: 10.1080/22221751.2020.1850180

[SOURCE: The Pirbright Institute]
Year(s) Of Engagement Activity 2020
URL https://www.star-idaz.net/2020/12/avian-influenza-viruses-can-combine-two-techniques-to-evade-vaccin...
 
Description BBC Today programme 24/01/2019 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview on BBC Today programme regarding potential development and use of gene drives in mice
Year(s) Of Engagement Activity 2019
URL https://www.bbc.co.uk/sounds/play/m00025bt
 
Description BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities.
Year(s) Of Engagement Activity 2019
 
Description BSI webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I presented a webinar hosted by the British Society for Immunology entitled "BSI Coronavirus webinar: What can we learn from the animal coronaviruses?", which sparked questions and discussions afterwards. I have since been contacted to establish new collaborations with people in the audience.
Year(s) Of Engagement Activity 2020
 
Description Big Band Science Event- AH, ER, LVC, MdP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Big Bang Fair South East - RC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Regional science festival/event - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Big Bang SE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Participation (HB and MA) in Big Bang SE
Year(s) Of Engagement Activity 2019
URL https://www.thebigbangfair.co.uk/
 
Description Big Bang UK- Jennifer Simpson 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Big Bang UK is a science competition. JS acted as moderator for final projects submitted by students from across the UK.
Year(s) Of Engagement Activity Pre-2006,2019
 
Description Blenheim High School Fair - DB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Team members attended sessions at a local high school with secondary school children and those in the 6th form to talk about paths into scientific careers, sharing their experiences of working at The Pirbright Institute. Approximately 300 students attended and it stimulated increased interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Policymakers reported greater interest in deer-associated diseases including EHDV and BTV
Year(s) Of Engagement Activity 2018
 
Description Brownies-AH 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talking to the Brownies about science and their careers
Year(s) Of Engagement Activity 2019
 
Description Bull/Intel press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The Integrative Biology and Bioinformatics group at Pirbright has acquired a bespoke computer cluster for genomics from Atos/Bull. Paolo Ribeca and Bryan Charleston were asked by Atos/Bull and Intel to contribute to a case study that illustrates the usefulness of high-performance computing in combating animal diseases and improving livestock welfare.
Year(s) Of Engagement Activity 2017
URL http://globenewswire.com/news-release/2017/01/10/904852/0/en/The-Pirbright-Institute-chooses-an-Atos...
 
Description CC Careers Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact MA participated in a careers fair at Collingwood College
Year(s) Of Engagement Activity 2019
 
Description CNN interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with CNN journalist. Journalist later followed up asking me to check and clarify some issues.
Year(s) Of Engagement Activity 2019
 
Description Camberley Library Fun Palace 2018 - JM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Centre of excellence for research on avian diseases (CERAD) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I was invited to present my work at the UK-China Centre of excellence for research on avian diseases (CERAD) meeting attended by researchers from UK, China and Thailand. There was lots of discussion about the research and future directions, including potential collaborations.
Year(s) Of Engagement Activity 2017
 
Description Chair - Royal Entomological Society Session on Insect Vectors 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chaired session on Insect Vectors including selecting speakers and managing session.
Year(s) Of Engagement Activity 2019
URL https://www.royensoc.co.uk/sites/default/files/RES%20Ento%20'19%20Reg.%20Leaflet_web.pdf
 
Description Chair and Co-Organiser for UK Vector-borne Diseases Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact UK Vector-borne Diseases meeting held bi-Annually. Half day sessions on 2nd, 9th, 16th, 23rd November 2020. Chaired session on 9th November 2020. Meeting was held online with invited and selected presentations and a poster session. Also included funders from Defra and BBSRC.
Year(s) Of Engagement Activity 2020
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Cheltenham Science Festival 2018 - JA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - JM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - JP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major national science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - RC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - SV 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Display at major science festival: changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018-DP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major national science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival- AH, ER, JC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Present at the Pirbright stand to discuss science with the public
Year(s) Of Engagement Activity 2019
 
Description Cheltenham Science festival - LB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact National science festival which Team members attended to demonstrate to the public how scientists at The Pirbright Institute can work to contain and control viral outbreaks. Over 500 people accessed the information and this stimulated increased interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Cheltenhan Science Festival - Dana Perry 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact DP helped to run a stand at the festival, questions from the general public stimulated increased interest in science and research and increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Commentary on AHSV outbreak in Thailand in Science Magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 'Thailand scrambles to contain major outbreak of horse-killing virus' - Article in Science Mag April 2020
Year(s) Of Engagement Activity 2020
URL https://www.sciencemag.org/news/2020/04/thailand-scrambles-contain-major-outbreak-horse-killing-viru...
 
Description Conference session organiser at MMC2017 - Host Pathogen Interactions 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities.
Year(s) Of Engagement Activity 2012,2014,2015,2017
 
Description Coronavirus lecture MSc students (Surrey) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact A lecture was presented on the replication, cellular interactions and pathogenesis of coronaviruses to 15-20 MSc students from University of Surrey. The students were engaged and interested, answering and asking questions during the session.
Year(s) Of Engagement Activity 2016,2018
 
Description DARPA visit April 2017 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Hosted visit by US funding agency programme manager to The Pirbright Institute
Year(s) Of Engagement Activity 2017
 
Description Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans.
Year(s) Of Engagement Activity 2019
 
Description Demonstrating Mathematics (Angita Shrestha) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Angita Shrestha (PhD student within Avian Influenza group) provided help in a Maths session to the new Oxford Doctoral Training Porgramme (DTP) cohort.
Year(s) Of Engagement Activity 2018
 
Description Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Diamond Light Source Open day - HJM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A public open day for Diamond Light Source, which Pirbright attended as a user of the facility to showcase research being performed at Pirbgith in collaboration with Diamond. There was a lot of interest in the fundamental research and sicussion about future plans and how it fit with the facility at Diamond.
Year(s) Of Engagement Activity 2019
 
Description Diego Friere Pesquisa Fapesp 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with journalist leading to article regarding release of transgenic mosquitoes into the environment to control dengue and other diseases
Year(s) Of Engagement Activity 2019
URL https://revistapesquisa.fapesp.br/en/2020/02/05/jacobina-controversy/
 
Description Discuss gene drives with NZ Parliamentary Commissioner 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Met NZ Parliamentary Commissioner to provide background information on, and discuss, gene drive systems. New Zealand is considering genetic and other control methods for invasive pests.
Year(s) Of Engagement Activity 2018
 
Description EM-UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact EM-UK scientific organiser
Year(s) Of Engagement Activity 2020
 
Description EM-UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Co-organiser and speaker for UKRI supported network for electron microscopists in the UK. I was one (or two) of the founder members. Meeting has been running for 5 years. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2020
 
Description EM-UK: A national network for electron microscopists 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Founder and Chair of EM-UK, a national network (with international participants) for electron microscopists. Includes a one or two day meeting with invited speakers, and email discussion list for questions, comments, advertising courses, advertising jobs. It has proved very popular with over 200 people registering for the discussion list, and 90+ delegates at each meeting. Administration is handled by the Royal Microscopical Society.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description EMBO Workshop: Molecular and population biology of mosquitoes and other disease vectors: vector and disease control 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Sex determination pathway in Anopheles gambiae as a target for mosquito control" given during the meeting held on 22 - 26 July 2019 in Kolymbari, Greece. Following a presentation a request was made to give an informal seminar at the Department of Life Sciences, Imperial College, London.
Year(s) Of Engagement Activity 2019
URL https://meetings.embo.org/event/19-mosquitoes
 
Description Encouraging women into science and engineering STEM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact MH Visited Warwick School, Redhill to talk to secondary students about careers in STEM. A very positive outcome and well received.
Year(s) Of Engagement Activity 2018
 
Description Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza. Presented by Deimante Lukosaityte at Influenza Update meeting 4th - 15th December 2020: The University of Liverpool (online meeting) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The talk describes a technique for the development of immunotherapy to protect poultry from Infectious diseases such as avian influenza viruses. The talk provided evidence that recombinant antibodies can provide passive immunity to protect chickens from avian influenza. Several mAbs generated from mice hybridomas targeting hemagglutinin (HA) of H9N2 virus were converted into single-chain variable fragment (scFv) antibodies. Recombinant scFvs were purified from insect cell culture supernatants and showed it could retain neutralization capacity against H9N2 virus in vitro. To test therapeutic scFv efficacy in vivo we selected two of the recombinantly produced scFv antibodies for prophylaxis and treatment of chickens infected with H9N2 UDL-01 virus. Intranasally treated birds showed reduced disease manifestation and virus shedding. These results indicate that antibody therapy could be beneficial for the provision of rapid treatment for reducing disease impacts in poultry.
Year(s) Of Engagement Activity 2020
URL https://www.gla.ac.uk/researchinstitutes/iii/cvr/events/influenza/
 
Description Epizone participation by team member 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Postdocteral scientist attended poster session at EPIZONE, "Breaking walls" Berlin 2019
Year(s) Of Engagement Activity 2019
 
Description European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork.
Year(s) Of Engagement Activity 2018
URL http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi...
 
Description Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry.
Year(s) Of Engagement Activity 2019
URL https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn...
 
Description Farnborough Sixth Form College Careers Fair - Chris Chiu 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact CC engaged at a careers day, and answered questions presented by sixth form students about working in science. Increased the visibility of The Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Farnborough futures careers event - HJM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The careers event aimed to introduce the range of careers available at Pirbright. In addition I discussed my own career progression and highlighted the range of possible careers that I could have entered. Finally, I discussed some details of the research with interested students. The students had a wide range of backgrounds and career aims but were interested to hear about the Institute and the sort of work opportunities available. Several of them planned to follow up by investigating future job opportunities at Pirbright.
Year(s) Of Engagement Activity 2019
 
Description Gene Drive Resarch Sponsors and Supporter's Forum meeting Montreal Sept 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Forum met to discuss the state of the art and future considerations for gene drive research. Ongoing deliberations including specific follow-up meetings.
Year(s) Of Engagement Activity 2018
 
Description Genetic engineering speeds up poultry vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Researchers report the rapid generation of a bivalent vaccine against Marek's disease and avian influenza

Scientists at The Pirbright Institute have used genetic engineering to develop a vaccine that protects birds against both Marek's disease and avian influenza. They say the process is faster and more efficient compared to previous methods, which will allow poultry vaccine producers to rapidly update vaccine strains in order to keep up with virus evolution.

In a study published in the journal Vaccines, the team used the gene editing tool CRISPR/Cas9 to insert an avian influenza gene into the turkey herpesvirus (HVT) that is used in Marek's disease vaccines. The gene codes for haemagglutinin (HA), an influenza protein that is key for virus entry into host cells and is therefore an important target of the host immune response to block infection.

"HVT is already widely used in vaccines against Marek's disease and can be administered to eggs, enabling automated delivery and providing birds with protection from the day they hatch. The additional HA gene we have incorporated will be expressed by HVT when it replicates in host cells, meaning that a single dose of vaccine induces immunity against both viruses", explained Professor Munir Iqbal, Head of the Avian Influenza group at Pirbright.

"The genetic engineering process we have developed using CRISPR/Cas9 is far quicker and more efficient than previous technologies, as well as being very consistent and accurate. These attributes are essential for providing fast and reliable vaccine production to protect poultry", Prof Iqbal added.

Mutations can occur with high frequency in HA proteins, enabling influenza viruses to evade immunity generated by vaccines. Using CRISPR/Cas9 to create new vaccines will help tackle evolving viruses by reducing the time it takes manufacturing companies to adapt their vaccine strains to match these mutations, allowing faster responses to outbreaks and providing better protection.

Although this gene editing method is very reliable, a small number of HVT viruses fail to incorporate the HA gene into their own genome effectively. To ensure HA is being expressed in the vaccine, the team exploited the HA protein's ability to bind to molecules on the surface of red blood cells.

Chicken cells infected with the successfully modified HVT virus express HA on their surface which red blood cells attach to, forming a clump that can be visualised using microscopy. This simple test improves the speed at which suitable vaccine candidates can be identified and has a much broader application as it can also be used for other viruses that incorporate proteins which interact with red blood cells.

"Improving how we make vaccines is critical for preventing avian influenza outbreaks. Our work could help reduce the spread of disease between birds and reduce the risk of infection for people who work closely with poultry", Prof Iqbal said. "Now that we have developed a rapid method for generating this modified vaccine, our next steps will be to study the vaccine's effectiveness in field trials."
Year(s) Of Engagement Activity 2020
URL https://www.cabi.org/vetmedresource/news/66612
 
Description Gordon's schools careers Fair-AH 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Provoking interest in a range of science career paths
Year(s) Of Engagement Activity 2020
 
Description Guest lecturer MSc Imaging course at University of Copenhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects.
Year(s) Of Engagement Activity 2018
 
Description Guest lecturer for PhD course in EM, University of Copenhagen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. Increase visibility of The Pirbright Institute
Year(s) Of Engagement Activity 2019
 
Description H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans.
- Avian influenza virus evolution and efficacy.
-
Year(s) Of Engagement Activity 2018
 
Description H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Focus of the conference was to improve control against infectious diseases affecting poultry and livestock.
Year(s) Of Engagement Activity 2018
 
Description High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. Presented via Webinar, organized by Boehringer Ingelheim, 3rd July 2020. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk entitled; High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. talk was organized by Boehringer Ingelheim, 3rd July 2020 and presented via Webinar.
Year(s) Of Engagement Activity 2020
 
Description Holt School Surrey. Bee meadow & A-level outreach Talk. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I discussed the importance of pollinators for biodiversity and food security with the younger students. I also discussed careers in science with A-Level students. There was good interaction and many questions surrounding both topics.
Year(s) Of Engagement Activity 2018
 
Description IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation (meeting 12-15 April and report) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Participated as member in Technical Subgroup on Synthetic Biology and Biodiversity Conservation of International Union for Conservation of Nature (IUCN). Meetings, online discussion and ultimately a report to Task Force and will ultimately go to IUCN General Assembly.
Year(s) Of Engagement Activity 2018,2019
 
Description Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Imagineering Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talked to the general public about Pirbright science and Beekeeping
Year(s) Of Engagement Activity 2019
 
Description Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dissemination of research outputs. Improvement of vaccines and diagnostics.
Year(s) Of Engagement Activity 2018
 
Description Improving vaccines and diagnostics for Avian influenza viruses affecting poultry. Presented at the International Poultry Expo "Poultry Science Conference", Lahore, Pakistan, 13-15 September 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description InFocus article (Jennifer Simpson) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact InFocus review article for EM-UK meeting (2017)
Year(s) Of Engagement Activity 2017
 
Description Influenza update meeting (Pengxiang Chang) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact presented work entitled: Antigenic characterization of avian influenza H7N9 virus by in vitro immune escape mutant selection method.
Year(s) Of Engagement Activity 2018
 
Description InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures.
Year(s) Of Engagement Activity 2018
URL https://www.alphavisa.com/isessah-innovsur/2018/
 
Description Innovate Guildford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Institute stand at Innovate Guildford science festival. Visitors to stand able to discuss issues related to animal diseases and their control (with a particular focus on influenza and on use of genetic modification technologies)
Year(s) Of Engagement Activity 2017
 
Description Innovate Guildford (Angita Shrestha): 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact GENERAL SCIENCE
Year(s) Of Engagement Activity 2019
 
Description Innovate Guildford - DB & KC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Public science event where team members participated on a Pirbright Institute stand which contained activities to help the public understand how scientists can help to contain and control viral outbreaks. Over 500 members of the general public attended which stimulated increased interest in science and research and led to requests for more information.
Year(s) Of Engagement Activity 2019
 
Description Innovate Guildford 17 March 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk and exhibit at Innovate Guildford - >100 for talk, probably >500 for exhibit. Both sparked questions and discussion afterwards.
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically.
Year(s) Of Engagement Activity 2018
URL https://www.guildford.gov.uk/IG18
 
Description Innovate Guildford 2018 - SB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Regional science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford 2018 - SV 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Display at regional science/innovation festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford, ND 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presented at the Pirbright Institute stand discussing science performed by the Institute with the general public. The stand focussed on an exhibit on avian influenza virus but more general virology topics were also discussed including our research.
Year(s) Of Engagement Activity 2017
 
Description Innovate Guilford-AH, AA, ER, EL 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact General science festival engaging the public in the research undertaken at Pirbright
Year(s) Of Engagement Activity 2019
 
Description Institute stand at Surrey Vet School open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Interactions between receptor-binding, immune evasion and glycan shielding. Presented by Joshua Sealy at Biophysics and evolution: improving models to predict influenza vaccine effectiveness) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Influenza viruses have an error-prone polymerase complex that facilitates a mutagenic environment. Antigenic mutants swiftly arise from this environment with the capacity to persist in both humans and economically important livestock even in the face of vaccination. Furthermore, influenza viruses can adjust the antigenicity of the haemagglutinin (HA) protein, the primary influenza immunogen, using one of four molecular mechanisms. Two prominent mechanisms are: (1) enhancing binding avidity of HA toward cellular receptors to outcompete antibody binding and (2) amino acid substitutions that introduce an N-linked glycan on HA that sterically block antibody binding. In this paper, we investigate the impact that adsorptive mutation and N-linked glycosylation have on receptor-binding phenotype, virus replicative fitness and antigenicity. We show that in the context of adsorptive mutation that N-linked glycosylation can mitigate virus attenuation. We show that in the absence of adsorptive mutation, N-linked glycosylation can attenuate virus this indicating a cooperative role between adsorptive mutation and N-linked glycosylation.
Year(s) Of Engagement Activity 2021
URL https://www.physicsoflife.org.uk/biophysics-and-evolution.html
 
Description International Avian Respiratory Disease Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Michael presented his research at the 2018 International Avian Respiratory Disease Conference in the US to an audience of avian researchers and representatives form the poultry veterinary vaccine industry. This sparked discussion and potential future collaborations
Year(s) Of Engagement Activity 2018
 
Description International Day of Women and Girls in Science 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I gave a quote as a STEM ambassador about why I think it is important to make sure women and girls have the same opportunities in STEM. This was shared on social media to celebrate International Day of Women and Girls in Science, a UN-led initiative.
Year(s) Of Engagement Activity 2019
 
Description Interview with Associated Press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with a journalist from Associated Press about coronavirus research at The Pirbright Institute.
Year(s) Of Engagement Activity 2020
 
Description Interview with BBC Radio Surrey 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Interview with journalists from BBC Radio Surrey on the breakfast show about coronavirus research at The Pirbright Institute.
Year(s) Of Engagement Activity 2020
 
Description Interview with BuzzFeed News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with a journalist from BuzzFeed News about coronavirus research at The Pirbright Institute.
Year(s) Of Engagement Activity 2020
 
Description Interviews to discuss COVID vaccine results 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Radio interviews (BBC Radio Surrey and Oxford), television interview (BBC South Today) and interviews with press to discuss results from our studies evaluating COVID-19 vaccine candidates in pigs.
Year(s) Of Engagement Activity 2020,2021
 
Description Invited Chair at European Congress of Entomology (Naples,July) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges.
Year(s) Of Engagement Activity 2018
URL http://www.ece2018.com/scientific-programme/day-1-monday-2-july/
 
Description Invited Lecture - Public Health Interest Group (London School Hygiene and Tropical Medicine) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk presented and discussion session particiation (09/04/19)
Year(s) Of Engagement Activity 2019
 
Description Invited Lecture - Wageningen University and Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk title: Culicoides-borne arboviruses in Europe - Invited lecture
Year(s) Of Engagement Activity 2019
 
Description Invited Presentation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presentations at the European PRRS Research Award ceremonies
Year(s) Of Engagement Activity 2016,2017
 
Description Invited lecturer for MSc Biological Electron Microscopy, University of Copenhagen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects.
Year(s) Of Engagement Activity 2019
 
Description Invited member of the Program Committee of AlCoB (Algorithms for Computational Biology) 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I was invited to join the Program Committee of the Algorithms for Computational Biology conference 2016
Year(s) Of Engagement Activity 2016
URL http://grammars.grlmc.com/AlCoB2016/pc.php
 
Description Invited member of the Program Committee of AlCoB (Algorithms for Computational Biology) 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I was invited to join the Program Committee of the Algorithms for Computational Biology conference 2018
Year(s) Of Engagement Activity 2018
URL http://grammars.grlmc.com/AlCoB2018/pc.php
 
Description Invited member of the Program Committee of ECCB (European Conference on Computational Biology) 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I was invited to join the Program Committee of the European Conference on Computational Biology 2016
Year(s) Of Engagement Activity 2016
URL https://www.ebi.ac.uk/eccb/2016/home/committees-2/index.html
 
Description Invited oral presentation at 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited oral presentation: 'Trying to hit a moving target: Novel approaches to porcine reproductive and respiratory syndrome virus vaccine development', 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China
Year(s) Of Engagement Activity 2018
 
Description Invited presentation at the Friedrich Loeffler Institute (January; Riems) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings
Year(s) Of Engagement Activity 2019
 
Description Invited presentation: 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Invited by the British Society for Immunology to give a presentation on vaccine research at the 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens, Berkeley, UK.
Year(s) Of Engagement Activity 2018
 
Description Invited seminar at INRAE, France 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited seminar to present our recent and ongoing PRRSV research
Year(s) Of Engagement Activity 2019
 
Description Invited speaker - Moredun 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on Bioimaging capabilities at Pirbright to Moredun Institute. Attended by Head of Bioimaging at Roslin too, increased links between these institutes.
Year(s) Of Engagement Activity 2016,2018
 
Description Invited speaker - PHE Colindale 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on high containment microscopy, asking for my advice prior to the design of a new high containment microscopy facility at PHE. This sparked a discussion at the end of the meeting, and several key points of advice that I put forward for them to consider during this process. I made it clear that I am available for other discussions at a later date if needed.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker - RMS EM School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to lecture on certain aspects of electron microscopy. I provided advice on individuals difficulties they had with sample preparation. Delegates had the opportunity to ask me any questions then had relating to any sample type.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "The Host-vector-pathogen Interface of Culicoides-borne Bluetongue Virus" at the VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 4th-5th December 2018
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at APHA surveillance meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at Imperial College 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Gave a talk on our recent research in swine influenza. Discussions with PIs at Imperial after the talk. Established collaborations.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at the British VeterinaryPoultry Association 2018 meeting at Boehringer Ingelheim 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact I was invited to present my research findings at the British Veterinary Poultry Association 2018 meeting, held at Boehringer Ingelheim.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker, Vienna Veterinary School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gave a guest lecture at the Veterinary school in Vienna. There were a lot of questions and discussion after the talk. As a result established collaboration with Gerner Wilhelm's group.
Year(s) Of Engagement Activity 2019
URL https://www.vetmeduni.ac.at/de/graduate-school-pig-and-poultry-medicine/
 
Description Invited talk at Nipah Virus International Conference, Singapore 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on our ongoing work to develop a Nipah virus vaccine for pigs.
Year(s) Of Engagement Activity 2019
 
Description Invited talk at World Vaccine Congress, Washington DC, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussed the potential for structural vaccinology to advance livestock vaccine development including examples of FMDV, bRSV and PRRSV
Year(s) Of Engagement Activity 2019
 
Description Invited talk on 28th September 2020 on ''Challenges and opportunities for control of infectious animal diseases including zoonosis' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact International Webinar of 'Epistemological approaches to animal disease control programmes with special reference to rabies'
Year(s) Of Engagement Activity 2020
 
Description Invited to attend and present at the RSPCA Lay members Forum, Royal Society London 10th of December 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Invited to attend to the RSPCA Lay members Forum, Royal Society London 10th of December 2018 and present on the ethical review process of animal research
Year(s) Of Engagement Activity 2018
URL https://science.rspca.org.uk/sciencegroup/researchanimals/ethicalreview/differentsystems/uk/events
 
Description Isabelle Dietrich - Bishop David Brown School Careers Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact >100 students attended careers fair. Informed students about The Pirbright Institute's work and career opportunities.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Collingwood College Careers Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact >100 students attended careers fair. Informed students about The Pirbright Institute's work and career opportunities.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Talk at "Symposium on New Emerging Mosquito-Borne Diseases and Vectors", Taiwan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference presentation, followed by questions and discussions and establishment of new collaborations.
Judged poster competition. Visited collaborators' institutes to introduce The Pirbright Institute's work in general and our group's work in particular.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Talk at RIVR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Conference presentation, followed by questions and discussions.
Year(s) Of Engagement Activity 2020
 
Description Jennifer Simpson - Big Bang Competition judge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact The Big Bang Competition recognises and rewards young people's achievements in all areas of science, technology, engineering and maths (STEM), whilst providing them with the opportunity to build their skills and confidence in project-based work. The Competition is open to all UK residents in full-time education or training.
Year(s) Of Engagement Activity 2017,2018
 
Description Jennifer Simpson - Careers Fair at Woking High School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Pirbright Institute stand at the careers fair. Speak to students interested in a career in science. Sparked questions and discussions.
Year(s) Of Engagement Activity 2018
 
Description Jennifer Simpson - Girls into STEM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Outreach activity for girls in local schools to demonstrated the variety of careers available within the STEM sector.
Year(s) Of Engagement Activity 2018
 
Description Jennifer Simpson - InFocus article on Bioimaging in high containment 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Magazine article describing the facilities for imaging in high containment at Pirbright.
Year(s) Of Engagement Activity 2018
 
Description Jennifer Simpson - Surrey MSc students visit to Pirbright 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Jenny organized a practical session where the students prepared their own samples for the confocal microscope, then they were able to image these samples using our instrument. The activities provoked questions and discussion. This session is always very warmly received by the students.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description Katy Moffat - Surrey MSc student visit to Pirbright 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Katy ran a small workshop for the students which enabled them to see the whole flow cytometry workflow. These activities provoke questions and discussions, and are always very warmly received.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description Keynote speaker - 89th IUVSTA Workshop, Poland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote seminar to 'high vacuum' community, including life scientists and physical scientists, with experience in microscopy or other high end analystical techniques. increased visibility of the Pirbright Institute.
Year(s) Of Engagement Activity 2019
 
Description Keynote speaker - Danish Virology Society Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was personally invited to be keynote speaker at the annual meeting of the Danish Virology Society, to talk about high containment microscopy of cell biology of host-virus interactions. The meeting was held at the State Serum Institute in Copenhagen, followed by a social evening which enabled me to add new contacts into my network. This invitation came direct from the Danish Virology Society, independent of the work I already do with the University of Copenhagen.
Year(s) Of Engagement Activity 2018
 
Description Kingdown School Warminster Wiltshire talk to 6th form students about career in science. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I presented my career path to the students to engage them on STEM careers. I had a good level of discussion and many questions.
Year(s) Of Engagement Activity 2018
 
Description LEAF open farm Sunday- JH, GM, WM, AH, KR, JS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The annual open farm day attended by businesses in the working in the farming industry in the Guilford area
Year(s) Of Engagement Activity 2019
 
Description Laboratory Science Animal association (LASA) meeting in Birmingham, Invited speaker 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Gave a presentation on the tolls we have developed to study swine influenza
Year(s) Of Engagement Activity 2018
URL http://www.lasa.co.uk/meetings/
 
Description Lecture of dynamics of vector-borne diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Two-hour lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at University of Cambridge
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021
 
Description Lecture on dynamics of infectious diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture as part of MSc in Veterinary Microbiology at University of Surrey
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016,2017
 
Description Lecture on entereic coronaviruses to MSc Students (Surrey) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact A lecture was presented on the pathology, diagnosis and detection of enteric coronaviruses, including virus replication and interaction with the host. The students were engaged and asked/answered question throughout the session. We were invited to repeat the lecture for the subsequent student intakes.
Year(s) Of Engagement Activity 2015,2016,2018
 
Description Lorin Adams (Gordon's School Careers Fair) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Lumpy Skin Disease D2R2 profile 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Provided expert opinion to the assessment (D2R2) of the risk of lumpy skin disease virus (LSDV) to the UK.
Year(s) Of Engagement Activity 2017,2018
 
Description MMC Learning Zone - invited speaker 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Microscience Microscopy Conference, speaker at the Learning Zone - specimen preparation for life sciences. Increase the visibility of Pirbright Institute
Year(s) Of Engagement Activity 2019
 
Description MMC2017 Learning Zone seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Presented a seminar on preparation of samples for electron microscopy to 24 MMC2017 delegates. Questions followed asking for advice on specific examples, also advice on interpretation of data and how to improve results.
Year(s) Of Engagement Activity 2012,2015,2017
 
Description MPEG-G working group at Pirbright 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact From 27 to 29 September 2017 Paolo Ribeca organised and hosted at Pirbright an ad-hoc meeting of the MPEG working group on genome compression (MPEG-G). The meeting focused on writing and improving technical documents needed to establish the upcoming standard. Many aspects of generation, use, storage and retrieval of genomic information were discussed during the meeting, as well as technical details of compression algorithms suitable for high-throughput sequencing data.
Year(s) Of Engagement Activity 2017
 
Description MSc student visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact I hosted several MSc students from University of Surrey, discussed avian research with them and demonstrated some laboratory techniques. The students gained an understanding of academic research and laboratory work.
Year(s) Of Engagement Activity 2018,2019
 
Description Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics
Year(s) Of Engagement Activity 2018
 
Description Microbiology Society Annual conference (UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Poster or oral presentation at Microbiology Society annual conference, a major international event. The participants included researchers from many different areas of science. This provides a platform to promote research to a wider audience as well as discuss the key findings with experts in my own field.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014,2015,2016,2017,2018,2019
 
Description Microbiology Society Annual conferences- invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Scientific talk on successful cross-species transmission of vector-borne viruses
Year(s) Of Engagement Activity 2019
 
Description Microbiology Society Avian Focus Meeting (UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact I gave a 15 minute oral presentation to an audience of around 80 people in 2016 and 2018. The audience consisted of researchers from many different scientific institutions from different areas of avian research. This was a great opportunity to present to experts in this field and gain novel insights into the project and the possible applications of my work.
Year(s) Of Engagement Activity 2016,2018
 
Description Microbiology Today article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018).
Year(s) Of Engagement Activity 2018
 
Description Microsoc 2018 "Structure-guided identification of a pathogen with pandemic potential" poster 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented a poster on our research at the MicroSoc annual meeting
Year(s) Of Engagement Activity 2018
 
Description Mock Interview Programme Cove School- Ai, AA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Molecular determinants modulating avian influenza H7N9 virus antigenicity. Presented at The Microbiology Society Annual Conference 2019, 8-11 April ICC Belfast, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Munir Iqbal: Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Negative Strand Virus 2018 Meeting "Structure-guided identification of morbilliviruses with zoonotic potential" Poster 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presented a poster on the Structure-guided identification of morbilliviruses with zoonotic potential at the international negative strand virus (NSV) meeting in Verona, Italy.
Year(s) Of Engagement Activity 2018
 
Description New Scientist interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with New Scientist regarding genetic control of mosquitoes
Year(s) Of Engagement Activity 2019
URL https://www.newscientist.com/article/2210190-parasite-brings-down-mosquito-numbers-in-parts-of-guang...
 
Description Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019