Science Services
Lead Research Organisation:
The Pirbright Institute
Department Name: UNLISTED
Abstract
Within the area of Science Services we have identified five areas that are vital for the efficient running of science for both internal and external users of materials and facilities. These are (1) Insectary Support; (2) Bioimaging; (3) Immunological Resources Support; (4) Sequencing and Bioinformatics; (5) Proteomics. These are national capabilities either due to the specialised and costly containment infrastructure required for their running and maintenance or that they have been built up as a result of long-term strategic funding and heavy use by both internal and external users.
Organisations
- The Pirbright Institute, United Kingdom (Lead Research Organisation)
- Institute of Zoology (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Huvepharma (Collaboration)
- Charles University, Czech Republic (Collaboration)
- AIMM Therapeutics (Collaboration)
- University of Dundee, United Kingdom (Collaboration)
- Bauchi State University (Collaboration)
- Animal and Plant Health Agency (Collaboration)
- Helmholtz Association of German Research Centres (Collaboration)
- University of St Andrews, United Kingdom (Collaboration)
- Harvard University (Collaboration)
- Liverpool John Moores University, United Kingdom (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- University of Pennsylvania, United States (Collaboration)
- National Center for Genetic Engineering and Biotechnology (BIOTEC) (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- Sisaf Ltd, QUEENS ROAD (Collaboration)
- National Taiwan University, Taiwan, Province of China (Collaboration)
- University of Minnesota, United States (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Chinese Academy of Agricultural Sciences (Collaboration)
- VUC Aarhus (Collaboration)
- APS Biocontrol (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- London Sch of Hygiene and Trop Medicine, United Kingdom (Collaboration)
- Government of Thailand (Collaboration)
- Thermo Fisher Scientific (Collaboration)
- Technical University of Denmark (Collaboration)
- National Health Research Institutes (NHRI) Taiwan (Collaboration)
- University of Greenwich, United Kingdom (Collaboration)
- National Cheng Kung University, Taiwan, Province of China (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- The Pirbright Institute, WOKING (Collaboration)
- National Institute of Genetics (Collaboration)
- Texas A&M University-Central Texas (Collaboration)
- Polytechnic University of Valencia (Collaboration)
- Washington State University, United States (Collaboration)
- Biomathematics and Statistics Scotland (BioSS) (Collaboration)
- Lancaster University (Collaboration)
- Syngenta International AG (Collaboration)
- Swedish University of Agricultural Sci, Sweden (Collaboration)
- Kansas State University, United States (Collaboration)
- University of Lleida, Spain (Collaboration)
- Rothamsted Research, United Kingdom (Collaboration)
- Centre for Genomic Regulation (CRG) (Collaboration)
- Enesi Pharma (Collaboration)
- University of Veterinary Medicine Hanover (Collaboration)
- University of Lyon (Collaboration)
- University of Parma, Italy (Collaboration)
- Wageningen University & Research (Collaboration)
- Unlisted (Collaboration)
- University of Kent, United Kingdom (Collaboration)
- Aviagen Group (Collaboration)
- Swiss Federal Institute of Technology (ETH), Zurich (Collaboration)
- Sanofi (Collaboration)
- Bern University of Applied Sciences (Collaboration)
- Zoological Soc London Inst of Zoology, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Queen's University of Belfast, United Kingdom (Collaboration)
- State Central Veterinary Laboratory (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- University of York, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University of Surrey, United Kingdom (Collaboration)
- University of Veterinary Medicine Vienna (Collaboration)
- Royal Veterinary College, United Kingdom (Collaboration)
- Leidos (Collaboration)
Publications
Peacock S
(2017)
Annual report of the Chief Medical Officer 2016: generation genome
Dalby A
(2017)
Rapid lineage assignment for the influenza A internal genes
Dalby A
(2017)
Rapid lineage assignment for the influenza A internal genes
| Title | E17 Art Trail - STEAM theme (Jennifer Simpson) |
| Description | Laboratory of Tiny Things installation which ran in London for three weeks. Open to the general public. |
| Type Of Art | Image |
| Year Produced | 2017 |
| Impact | No known impact |
| Title | The Pathologist - Through the Looking Glass (Jennifer Simpson) |
| Description | Article showcasing a gallery of beautiful images from all walks of laboratory medicine |
| Type Of Art | Image |
| Year Produced | 2017 |
| Impact | No impacts known |
| Description | The Science Services strategic grant provides unique resources to scientists both within and external to Pirbright. During the reporting period to date we have 1) Supplied insects to a variety of external users under MTA (ongoing). Outputs have included the analysis of gut microbiota in Culicoides biting midges and studies of their vector competence for arboviruses. Staffing has also been strengthened towards lab management of the two main insectary facilities in line with requirements of users. In addition, industrial income has been met as estimated within the impact plan and a total of >20 MTA's are extant for midge and mosquito supply. 2) Bioimaging facilities for internal users have been maintained with more than 50 registered users and a range of outputs in line with impact plan estimates derived from both microscopy and flow cytometry techniques. Workers in this area have retained direct links to relevant societies and provided a range of materials for outreach activities. In addition, a new strategic collaboration has been established with the Electron Bioimaging Centre at Diamond Light Source and a bid for a new Transmission Electron Microscope has been successful to facilitate this work (2019). 3) Sequencing of hybridoma collections has been initiated (>50 to date) and a committee formed for selection and distribution of resources that includes national and international experts (2017). This is aimed at providing immunological resources that are not commercially viable but nonetheless a limiting factor in studies of host and virus. Outputs include a dedicated website that is accessible to the public and enables searching and ordering of available reagents (2019). 4) In addition to the current MiSeq facility, a HiSeq Illumina sequencer has been installed (2018) and is running in containment and single cell encapsulation technology is in preliminary trials (2019). A total of 14 research groups have accessed these facilities to date (2019). 5) Proteomics support has been provided to at least seven internal groups and has also been assessed across site with a significant increase in demand. |
| Exploitation Route | Facilities within Science Services are provided across the groups at Pirbright and all receive at least some provision of support within the five distinct areas. We have targeted insect supplies and the immunological toolbox as being the most straightforward to provide to external users and both of these areas are progressing in making resources available. Both of these areas rely on centralizing both expertise and resources which would not be normally be supported at a single institution, improving both continuity and critical mass and are within the range of reporting identified within the impact plan. Bioimaging and sequencing in containment operate on a slightly different model of external access due to the constraint of the training required to access facilities, but plans are in place to improve the numbers accessing resources later in the ISPG programmes. The proteomics service is a purely internal service operated in collaboration with the University of Liverpool. |
| Sectors | Agriculture, Food and Drink |
| Description | The provision of Science Services has played a major role in underpinning a range of scientific discoveries outlined in the publications produced to date. These impacts would not be achieved without the supporting services described in this ISPG, facilitating a diverse collection of areas. Major areas include the use of DNA/RNA sequencing in containment where samples cannot be outsourced for this service and the production of both insect and animal lines that are unique to Pirbright under the national capability initiative. In addition, the development of bioimaging in containment has led to discussion with other groups active in the field in the UK and the formation of a working group around developing techniques. The production of insect and vertebrate hosts for viruses also forms a major aspect of our aim to carry out studies of virus infection in the natural hosts in addition to providing opportunities for methods to vaccinate or protect from infection. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal,Economic,Policy & public services |
| Description | BBSRC 18ALERT panel member |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Provision of multi-user equipment to core facilities to enable BBSRC remit science. Part of the remit for this call was to allow shared access from other institutions, widening the impact of BBSRC investment. |
| Description | BBSRC ALERT18 panel member (invited) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Panel for ALERT18 multi-user equipment award by BBSRC |
| Description | BBSRC Bioimaging Review |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | BBSRC-Newton Fund Agricultural Data Re-use Advisory Group |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Advice on re-usability of data generated in research projects. |
| Description | Bioimaging Steering Group |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Improving access and efficient organization of Bioimaging for researchers at Pirbright |
| Description | Contribution to a POSTnote on 'Reducing UK Antibiotic Use in Animals' |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | IUCN Assessment of Synthetic Biology and Biodiversity Conservation |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| URL | https://www.iucn.org/theme/science-and-economics/our-work/other-work/synthetic-biology-and-biodivers... |
| Description | Inter-institute imaging network |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | Invited member of RCaH Science Advisory Board |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | The Research Complex at Harwell is a UKRI funded building with the remit of enabling researchers across many disciplines to take advantage of the national facilities on the Harwell campus. RCaH is going through significant change at the moment and the advisory board has been asked to contribute to defining its future direction. |
| Description | Lumpy Skin Disease Control Strategy for Great Britain |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | Member of RMS EM Section committee |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | This committee informs the RMS on which areas to invest funds in regarding training, conferences, outreach events. RMS members are international. |
| Description | Membership of MPEG-G (standardisation of the compression of genomic information) working group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | Organised seminar series on Sequencing, Virus Evolution and Molecular Biology at Pirbright (with Luca Ferretti and Graham Freimanis) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | POSTnote Report on Climate and vector-diseases in humans in the UK |
| Geographic Reach | National |
| Policy Influence Type | Gave evidence to a government review |
| Description | Publication policy document for core facilities - EM-UK |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | I am a founder member of the network created for electron microscopists within UK, EM-UK. The annual meeting is highly productive, and training and managing core facilities is regularly discussed. Recognition of these facilities is essential for their continued existence so we produced a generic document hosted on the RMS website which can be adopted by any core facility in any institution, and describes the publication policy which users had to adhere to. This has already raised the profile of core facilities around the country and is a successful outcome from the EM-UK meetings. |
| Description | Royal Microscopical Society Microscopy Training Focussed Interest Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Royal Microscopical Society Training Focussed Interest Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | A review of the microscopy training courses available globally has been undertaken. We are in the process of collating and preparing a gap analysis. This will be used to guide RMS policy on training provided in the UK, both UK and international delegates. |
| Description | Scientific Advisory Group for Emergencies Exercise (Royal Society: 11/06/19): Examined simulated emergence of arbovirus in the UK with main decision making bodies and personnel. |
| Geographic Reach | National |
| Policy Influence Type | Gave evidence to a government review |
| Description | Training MSc students |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Delivered a new training session to MSc students teaching viral quantification assays. This lead to a greater understanding of laboratory techniques and academic research. |
| Description | University of Surrey MSc Vet microbiology - teaching (Jennifer Simpson) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Two days of teaching practical microscopy, a useful cross disciplinary skill for many researchers |
| Description | (CloudButton) - Serverless Data Analytics Platform |
| Amount | € 4,277,507 (EUR) |
| Funding ID | 825184 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2019 |
| End | 12/2021 |
| Description | A One Health approach to pan-valent morbillivirus vaccines |
| Amount | £773,237 (GBP) |
| Funding ID | BB/R019843/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 03/2021 |
| Description | Antigenic characterisation of infectious bursal disease virus to improve vaccination strategies and vaccine design |
| Amount | £450,685 (GBP) |
| Funding ID | BB/S014594/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 12/2021 |
| Description | Assessment of the immunogenicity of bovine herpesvirus 4-based vectors delivering Nipah virus glycoproteins in swine |
| Amount | £41,895 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2019 |
| End | 04/2019 |
| Description | Aviagen Industry Funding |
| Amount | £422,383 (GBP) |
| Organisation | Aviagen Group |
| Sector | Private |
| Country | United States |
| Start | 09/2019 |
| End | 12/2020 |
| Description | BBSRC IAA The Pirbright Institute |
| Amount | £300,000 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | BBSRC Industrial CASE (iCASE) studentship programme Oxford Interdisciplinary Bioscience Doctoral Training Partnership |
| Amount | £80,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Description | BBSRC business case for sequencing capacity in containment. |
| Amount | £560,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 03/2018 |
| Description | BBSRC responsive mode grant |
| Amount | £367,000 (GBP) |
| Funding ID | BB/P006841/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 03/2019 |
| Description | Biotechnology and Biological Sciences Research Council (BBSRC) and University of Oxford joint Doctoral Training Project |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 08/2022 |
| Description | British Egg Marketing Board PhD studentship |
| Amount | £76,000 (GBP) |
| Organisation | British Egg Marketing Board |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Broad and effective protection against influenza achieved by viral vectored vaccines |
| Amount | £1,607,691 (GBP) |
| Funding ID | MR/S037160/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 04/2022 |
| Description | Capital Infrastructure - PIrbright |
| Amount | £23,533 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 12/2017 |
| Description | Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence |
| Amount | £200,000 (GBP) |
| Funding ID | LKCS-2019- 665 |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 10/2022 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Amount | £1,209,348 (GBP) |
| Funding ID | BB/S001964/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2021 |
| Description | DARPA PREEMPT |
| Amount | $2,700,000 (USD) |
| Organisation | Defense Advanced Research Projects Agency (DARPA) |
| Sector | Public |
| Country | United States |
| Start | 10/2018 |
| End | 03/2022 |
| Description | Defining the circadian clock in chicken cells and its impact upon viral replication |
| Amount | £4,500 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 11/2020 |
| Description | Enhancing protective efficacy of avian influenza vaccines through targeted delivery of protective antigens to chicken immune cells |
| Amount | £98,212 (GBP) |
| Funding ID | BB/R50595X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2021 |
| Description | Genomia Project Grant |
| Amount | £174,052 (GBP) |
| Organisation | Genomia fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2020 |
| Description | H2020 work programme topic 9 Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy, work topic SFS-10-2017 Research and approaches for emerging diseases in plants and terrestrial livestock |
| Amount | € 5,986,250 (EUR) |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 05/2018 |
| End | 04/2023 |
| Description | Identification and evaluation of swine mAbs in pig influenza challenge model |
| Amount | $599,944 (USD) |
| Funding ID | OPP1201470 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 10/2018 |
| End | 10/2019 |
| Description | In vitro evaluation of peptide-based immune checkpoint inhibitors as potential molecular adjuvants for improved PRRS vaccines |
| Amount | £4,921 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 03/2020 |
| Description | Market research and technical feasibility of a bivalent porcine reproductive and respiratory syndrome / Nipah virus vaccine |
| Amount | £10,880 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 03/2020 |
| Description | NC3Rs Research Project Grant |
| Amount | £436,339 (GBP) |
| Funding ID | NC/R001138/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2019 |
| Description | OIE Twinning: Development of capacity for independent assessment of FMDV vaccines in Africa |
| Amount | $1,466,186 (USD) |
| Organisation | World Organisation for Animal Health |
| Sector | Public |
| Country | France |
| Start | 04/2019 |
| End | 03/2021 |
| Description | Oxford DTP - Diamond Light Source/Harwell |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Pirbright Institute Flexible Talent Mobility Account |
| Amount | £180,000 (GBP) |
| Funding ID | BB/S507945/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 03/2021 |
| Description | Pirbright Institute PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 08/2022 |
| Description | Pirbright Institute PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Pirbright Institute PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Description | Recombinant pseudorabies virus as a multivalent vectored vaccine platform for emerging and endemic porcine diseases |
| Amount | £80,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 09/2024 |
| Description | Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field. |
| Amount | £400,000 (GBP) |
| Funding ID | BB/S013792/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2021 |
| Description | SFS-10-2017 - Research and approaches for emerging diseases and pests in plants and terrestrial livestock: Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND) |
| Amount | € 5,986,250 (EUR) |
| Funding ID | 773701 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 06/2018 |
| End | 05/2023 |
| Description | Seed Catalyst Award |
| Amount | £25,527 (GBP) |
| Funding ID | ISCF-TFPSA-Pirbright |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 02/2019 |
| Description | Smart biomimetic nanomaterials for novel treatment and prevention of viral infection |
| Amount | £60,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2019 |
| End | 03/2022 |
| Description | The Global Challenges Research Fund |
| Amount | £640,473 (GBP) |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2024 |
| Description | The Pirbright Institute - University of Surrey PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 03/2023 |
| Description | The Pirbright Livestock Antibody Hub |
| Amount | $5,530,900 (USD) |
| Funding ID | INV-003007 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 10/2019 |
| End | 09/2024 |
| Description | The Pirbright Livestock Antibody Hub |
| Amount | NU$ 5,500,000 (UYU) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 09/2019 |
| End | 08/2024 |
| Description | Towards a novel multivalent poultry vaccine: Development of a recombinant infectious bursal disease vectored vaccine encoding conserved B- and T- cell epitopes from infectious bronchitis virus |
| Amount | £5,000 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 11/2020 |
| Description | Workpackage within a Horzion 20:20 grant |
| Amount | € 6,000,000 (EUR) |
| Funding ID | EU project 727393 Horizon 20:20 PALE-Blue |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2017 |
| End | 11/2020 |
| Description | [YY-EEID US-UK XXXX] Evaluating how immunosuppression influences influenza A virus transmission and evolution in wild and domestic birds |
| Amount | £606,360 (GBP) |
| Funding ID | BB/T008806/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2023 |
| Description | iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Title | A male-specific cell line from a mosquito Anopheles gambiae |
| Description | A new male-specific cell line from a mosquito Anopheles gambiae has been isolated from sexed neonate larvae. To our knowledge this is the only cell line derived exclusively from male mosquitoes. |
| Type Of Material | Cell line |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The cell line will greatly facilitate studies on components of the sex determination pathway and of dosage compensation machinery in mosquitoes. There are only several cell lines derived from Anopheles gambiae available and these are female-like. Over-expression of genes involved in male sex determination or dosage compensation is detrimental to female cells, hence use of male-derived cells is necessary for such studies. The cell line will become available upon acceptance of a manuscript describing characterization of that cell line. |
| Title | An ex vivo IBDV infection model using a chicken primary B cell culture system |
| Description | Recently, it has become possible to culture chicken primary B cells in vitro in the presence of a soluble construct of chicken CD40L that was made at The Pirbright Institute. We have demonstrated that these chicken primary B cells can be infected with infectious bursal disease virus (IBDV). This system will be validated and expanded to other B cell tropic viruses in order to replace the use of infected chickens in research, in an NC3Rs funded grant. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Using this system, we have determined that chicken primary B cells respond to IBDV infection by inducing Type I IFN responses. However, the induction is more pronounced in cells infected with an attenuated strain compared to a very virulent strain. This is consistent with the very virulent strain down-regulating antiviral responses to a greater extent than other strains which may, in part, explain its enhanced virulence. We also observed a reduction in the expression of key genes involved in B cell proliferation and activation following IBDV infection which was only possible by using the primary B cell culture system. |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/?term=broadbent+dulwich |
| Title | Appropriate FMD vaccine strains for East Africa and South East Asia and new adjuvants for FMD vaccines that provide longer duration immunity |
| Description | We have identifies appropriate Vaccine strains for Serotyoe O and A for East Africa and for South east Asia which are published now. Additionally we have identified potent and safe adjuvants which has been tested in cattle and provides longer duration immunity. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Governments of East Africa and Regional OIE centre at South East Asia and vaccine producers are aware about the strains and adjuvants. |
| Title | CRISPR/Cas9-based gene editing of avian herpesvirus vectors to develop novel recombinant vaccines |
| Description | Development of recombinant herpesvirus vaccines are usually achieved by classical homologous recombination methods. The advent of new genome editing tools has enabled its application on avian herpesvirus vaccine strains to develop new recombinant vaccines potentially capable of expressing protective antigens from multiple pathogens |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The major impact will be in the generation of novel vaccines that can simultaneously protect against multiple avian diseases |
| URL | http://www.poultryworld.net/Health/Articles/2016/12/Is-GM-technology-the-future-of-poultry-vaccines-... |
| Title | Cattle MHC genotyping |
| Description | Using the sequence data generated through the targeted pull down of MHC, we developed a full gene and more targeted PCR approach to genotype cattle for the MHC class I region. This has been applied to many hundreds of samples to enable us to select individuals for breeding as well as survey genetic diversity in beef and diary herds. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | After publication which we anticipate in 2019, we will appy this method to targeted herds and are already attracting industry interest. |
| Title | Deep sequencing to identify RNA packaging signals |
| Description | A novel and simple approach to identify predicted RNA secondary structures involved in genome packaging in positive sense RNA viruses (e.g. the picornavirus foot-and-mouth disease virus [FMDV]). By interrogating deep sequencing data generated from both packaged and unpackaged populations of RNA, we have determined multiple regions of the genome with constrained variation in the packaged population. Predicted secondary structures of these regions revealed stem-loops with conservation of structure and a common motif at the loop. Disruption of these features resulted in attenuation of virus growth in cell culture due to a reduction in assembly of mature virions. This study provides evidence for the involvement of predicted RNA structures in picornavirus packaging and offers a readily transferable methodology for identifying packaging requirements in many other viruses. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Impact so far is fundamental knowledge but with several potential avenues for future impact in for example improved vaccines. |
| Title | Detection of HA antigens of avian influenza viruses |
| Description | Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. |
| Title | Development of high-throughput assay for examining paramyxovirus fusion |
| Description | We have developed and optimised high-throughput assays (96 well plate format) to examine paramyxovirus fusion, using an adapted Bi-FC approach. We are using this to identify inhibitors of paramyxovirus, e.g. measles and RSV, fusion and attachment proteins. This has been integrated with next-generation platforms such as the Incucyte real-time imaging system available at The Pirbright Institute. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | We are using this assay to examine the innate immune restriction of paramyxovirus replication. |
| Title | IBDV Reverse Genetics System |
| Description | We have developed a reverse genetics system for IBDV. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | We have used the reverse genetics system to generate recombinant IBDVs and chimeric recombinant IBDVs that contain genes from classical and very virulent strains of IBDV in the background of a cell culture adapted attenuated strain. This will enable us to study the effect of individual virus genes on pathogenicity. |
| Title | Method for sequencing of ASFV (African Swine Fever Virus) based on long reads |
| Description | The ASFV genome is repetitive, due to the presence of families of genes that are present in multiple copies (>10). As a result, sequencing based on short reads only would not be able to reconstruct the genome in its entirety. In addition, good quality full genome sequencing of ASFV is complicated by persistence contamination with fragments of host DNA. We are developing a novel protocol that will allow the sequencing of the virus using long-read technologies (PacBio or Oxford Nanopore). Probe-capture libraries have been designed to mitigate the problem of host contamination by selectively purifying viral DNA from a wide range of different ASFV genotypes. Protocols are being developed to prepare high quality high molecular weight viral DNA from different sample types suitable for generating sequencing libraries for long-read sequencing. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | More than 100 samples from 18 different LMIC countries have been identified and collated for sequencing with the new protocol. They will be added to the web-portal for transboundary pathogens which is currently being developed thanks to BBSRC funding. |
| Title | Method to evenly load flowcells with multiple samples |
| Description | Pirbright has an Illumina NextSeq sequencing machine installed in containment. Given the large amount of sequencing reads produced by each run, multiple samples are usually multiplexed on the same flowcell. However, determining the correct concentrations needed to obtain the same amount of reads for each sample is a hard problem, and usually requires a number of expensive and material-consuming kits to be run prior to sequencing. We have developed a method that allows samples to be evenly multiplexed based only on Bioanalyzer data (we routinely run Bioanalyser on the samples anyway as a form of quality control). The method works well, and reliably across a wide range of sample concentrations and sequenced organisms. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The method greatly increased the quality of our output, and drastically simplified our workflow by eliminating the external quantification steps that were previously required. |
| Title | Optimisation of chicken kidney cell culture preparation |
| Description | We have optimised the method of extracting kidneys and preparing chicken kidney (CK) cell cultures from chickens. CK cells are used for in vitro assays to study avian viruses, in particular infectious bronchitis virus. |
| Type Of Material | Cell line |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This has increased the yield of viable cells and the quality of the cell cultures. We can now obtain the number of cells we require using fewer chicken kidneys, therefore requiring fewer chickens to be culled. This is an important development for the 3Rs. We hope to publish this method for others' information. |
| Title | Stable chicken cell lines overexpressing chicken IFITM1,2 and 3 |
| Description | In collaboration with Mark Fife, we have produced chicken stable cell lines overexpressing chicken IFITM1,2, 3 and a mutant chicken IFITM3 lacking palmitoylation sites. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | These cell lines will be used to evaluate the effect of the IFITM proteins on the replication of different viruses, including IBDV. |
| Title | UniMMap- a pipeline for mapping RNAseq data over repetitive immune complexes. |
| Description | To exploit the abundance of available short read sequencing data we have developed a pipeline that uses mappability to accurately measure transcription over repetitive gene complexes. This methods uses known haplotypes to examine regions of uniqueness, and then the RNAseq data from the individual to train the method to be species or individual specific. This is particularly important over gene complexes that contain genes involved in the immune system, that are often highly similar in sequence but can have profoundly different functions. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | the immediate impact will be adding fine resolution data to livestock gene expression atlas projects lead by the FAANG consortium. Further impact will be arising as this method is published and we apply it to numerous existing datasets the are publically avaialable as well as generated at Pirbright and by our collaborators. |
| Title | Use of reverse genetics to develop PPR DIVA vaccines |
| Description | Reverse genetics technique has been established for PPR virus in our laboratory. As PPR vaccine is a live attenuated virus, it is not possible to differentiate between vaccinated and infected animals (DIVA) in existing antibody assays. However using reverse genetics technique we have manipulated/mutated residues in the full-length cDNA of virus and rescued the live attenuated vaccine strain which worked as a DIVA vaccine. Using this technique a GFP ( Green fluorescent protein) has been introduced into the virulent PPR virus that helped to follow the virus in the infected goats. Similarly using this technique we have modified the existing live attenuated viruses ( Nigeria 75/1) and Sungri 96/1) in to recombinant marker vaccines that enables to differentiate between infection and vaccination ( DIVA). So we have demonstrated that reverse genetics tool can be used to study the pathogenesis and to develop the marker vaccines. This technique can be adapted for other negative strand viruses to design the DIVA vaccines. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | PPR DIVA vaccine developed that can differentiate between vaccinated and infected animals. This will be helpful to know the efficacy of vaccine by knowing the presence antibodies in animal is due to vaccination or infection. This will reduce the eradication time and will facilitate to declare freedom of diseases as soon as Possible without long waiting period. |
| Title | chimeric IBDVs |
| Description | Andrew Broadbent has engineered chimeric IBDVs expressing individual genes from a very virulent strain in the backbone of an attenuated strain. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | These chimeric strains can be used to define viral determinants of virulence. |
| Title | replication competent recombinant split-GFP infectious bursal disease virus |
| Description | We have generated a replication competent recombinant split-GFP infectious bursal disease virus (IBDV) where a small GFP11 molecule is tagged to the virus polymerase (VP1) to make IBDV-VP1-GFP11. Infected cells that express the GFP1-10 molecule fluoresce green when the GFP11 tag complements the GFP1-10. The IBDV-VP1-GFP11 colocalises with VP3 and dsRNA and therefore is likely to be present at the sites of virus replication. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This tool can be used to study IBDV replication complex development in infected cells. |
| Title | tetracysteine-tagged IBDV |
| Description | Andrew Broadbent has engineered a tetracysteine (TC)-tagged IBDV that can be used in live cell imaging and co-infection studies with the split-GFP IBDV. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | This tool, combined with the split-GFP IBDV, will enable us to study co-infection, super-infection exclusion, and the intracellular requirements for viral reassortment. |
| Title | Analysis of paramyxovirus replication using Incucyte real-time imager |
| Description | We have optimised a data analysis pipeline for the Incucyte real-time imager to allow us to track viral replication in a high-throughput fashion (up to 6 x 96-well plates). This is based on simultaneous analysis of phase, as well as green and red fluorescence. |
| Type Of Material | Data analysis technique |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Only preliminary data to date. |
| Title | Boosting the FM-index on the GPU |
| Description | The FM-index is a data structure that lies at the core of most modern short-read aligners. Our work describes what is perhaps the first implementation of the FM-index on the GPU able to take full advantage of the high hardware parallelism (large number of computing cores) offered by modern Graphical Processing Units. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2016 |
| Provided To Others? | No |
| Impact | Short-read aligners are instrumental to the analysis of high-throughput sequencing experiments. As alignment is central to most analysis pipelines, speeding it up is essential to improve the performance of many bioinformatics tools. Thanks to our new algorithm FM-index based searches can be sped up by a large factor on all computers where a suitable GPU is present. |
| Title | Full length cattle MHC genes |
| Description | Using our method for full length MHC gene amplification, the largest reference set ever produced from common haplotypes has been sequenced and deposited in the publicly available data IPD-MHC with associated research tools. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | None yet, but it will allow far greater resolution when analysing MHC polymorphism and evolution in cattle populations. |
| URL | https://www.ebi.ac.uk/ipd/mhc/group/BoLA/ |
| Title | Method to detect the expression of repetitive genes |
| Description | Reconstructing expression levels of genes having a high repeat content is difficult, due to the impossibility of assigning RNA-sequencing that have multiple mappings to their correct originating location. In collaboration with the Immunogenetics group, the Integrative Biology and Bioinformatics groups are developing a data analysis method to circumvent the problem.The method has already been shown to be effective on some KIR genes in cattle. An essential component of the immune system, their family is rich in repeated members and repetitive regions, making the technique essential if one wants to study them. |
| Type Of Material | Data analysis technique |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Being able to resolve the expression of repetitive genes, which are plentiful in most mammalian genomes, would be essential to the high-precision study of many important gene families, including most of the genes of the immune system. The technique has already proven itself effective on a real-life problem, and holds the potential to be extended to many more biological systems |
| Title | Viral assembly pipeline |
| Description | The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust viral assemblies out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, assembling of viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; uneven coverage due to low-quality material or the genomic material of the virus being RNA; the viral nucleic acid being almost lost in the background of nucleic acid of the host. Our pipeline overcomes most of those problems, and is even able to detect different viral strains being present together in the same sample. It can also be used on metagenomic environmental samples. |
| Type Of Material | Data analysis technique |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. |
| Title | Viral variant calling pipeline |
| Description | The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust variant calling for viral sequences out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, calling variant for viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; very high genome coverage, which slows down most existing variant callers; the presence of a potentially very high number of different haplotypes for RNA viruses, which is an unusual scenario in variant calling. Our fast and sensitive Bayesian pipeline overcomes most of those problems. |
| Type Of Material | Data analysis technique |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. |
| Description | Anihwa Call 1 |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | 1. Conducted challenge experiments in goats to study pathogenicity. 2. Developed NGS technology to sequence PPR whole genome. |
| Collaborator Contribution | FLI has conducted transmission study between different species ( Goats, pig, camel). For the first time they showed that pigs are clinically infected by PPR virus. |
| Impact | Joint Publications |
| Start Year | 2013 |
| Description | Assembly of CHIKV in host cells/JEOL TEM training |
| Organisation | National Cheng Kung University |
| Country | Taiwan, Province of China |
| Sector | Academic/University |
| PI Contribution | Visit to Tainan in May 2017, provided training in cellular imaging of virally infected cells. Gave a seminar entitled Bioimaging at The Pirbright Institute. Hosted two visitors for two weeks in Bioimaging at Pirbright, provided training in EM sample preparation and data interpretation. |
| Collaborator Contribution | Professor Shang-Rung Wu hosted me for one week in Taiwan. During the visit to Pirbright, the Taiwanese researchers provided training on JEOL 2100F TEM to Pirbright researchers. Professor Wu provided prepared samples for imaging at a later date. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production. |
| Collaborator Contribution | The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses. |
| Impact | This project started in January 2020. |
| Start Year | 2020 |
| Description | Chicken Microbiome - Robert La Ragione - University of Surrey |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing sequencing data of gut microbiome from chickens infected with avian influenza viruses. |
| Collaborator Contribution | Sharing expertise in the analysis of microbiome data |
| Impact | Joint manuscripts and funding opportunities are being explored |
| Start Year | 2019 |
| Description | Collaboration on replication of mumps virus in cells |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes |
| Collaborator Contribution | Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM. |
| Impact | No outcomes yet |
| Start Year | 2018 |
| Description | Collaboration with Bauchi State Veterinary Services, Nigeria |
| Organisation | Bauchi State University |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | We have provided expertise on sheeppox, goatpox and lumpy skin disease virus diagnosis and epidemiology |
| Collaborator Contribution | Our collaborators in Bauchi State have provided virus samples and epidemiological data |
| Impact | Preliminary data was used to support successful funding via a BBSRC Impact Accelerator Award, and a Pathways to Impact project in BBSRC project BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines" |
| Start Year | 2016 |
| Description | Collaboration with State Central Veterinary Laboratory, Mongolia |
| Organisation | State Central Veterinary Laboratory |
| Country | Mongolia |
| Sector | Public |
| PI Contribution | We provided tools, techniques and expertise on sheeppox and goatpox |
| Collaborator Contribution | Our colleagues provided data and field samples |
| Impact | A workshop was held in Pirbright in March 2017, and a return workshop in Ulaanbaatar in July 2017. Preliminary data supported successful grant applications for an Impact Accelerator Award, and a Pathways to Impact project in BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines". |
| Start Year | 2016 |
| Description | Collaboration with University of Copenhagen CFIM on cell biology of virus-host interactions |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input into virus projects which come in to the microscopy core facility at the University. Limited practical work and training given to researchers there. Includes lecturing/organisation of MSc and PhD courses at Copenhagen. PH awarded Visiting Professorship. |
| Collaborator Contribution | Research projects are presented to the core facility, I advise on the best route for achieving the data required and those researchers complete preliminary data following my advice. Collaborators are then able to produce the best possible samples for further advanced microscopy as necessary. |
| Impact | No tangible outcomes yet as we are in early stages. This is multi-disciplinary as projects can come from several University departments (medical, pathology, cell biology, veterinary, food), and other Universities in Denmark (DTU). University awarded Visiting Professorship |
| Start Year | 2018 |
| Description | Collaborative PhD student project on virus-bacteria-host-vector interaction |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a collaborative PhD studentship funded by The Pirbright Institute between Pirbright and the Roslin Institute. The student is investigating how bacteria or bacterial compounds will effect bluetongue virus replication in mammalian host cells with a specific emphasis on skin derived migratory cells. While mainly based at Pirbright the student will visit the Roslin Institute and spend some time in the lab of Prof. Jane Hope. |
| Collaborator Contribution | The student will carry out the main laboratory work at Pirbright including infection studies of ruminant primary host target cells in the presence/ absence of bacterial compounds. There will be regular meetings between the students and supervisors at Pirbright and at Roslin (at least monthly by skype) and the student will visit the Roslin group for specific work aspects such as flow cytometry of skin derived pseudo-afferent lymph cells. Roslin will also make cattle pseudo-afferent lymph cells available to the student and Pirbright for ex vivo BTV infection studies. |
| Impact | bacteriology, virology, immunology, virus-host interaction |
| Start Year | 2019 |
| Description | Collaborative studentship PPRV |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Practical laboratory work and in vivo animal studies carried out |
| Collaborator Contribution | Intellectual input in scientific remit of studentship, training of student, use of facilities and lab |
| Impact | DOI: 10.1128/JVI.01471-18 Thesis: The immune response to live, attenuated peste des petits ruminants virus vaccines |
| Start Year | 2014 |
| Description | Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I develop a research project proposal in which we are investigating how evolutionary changes in the H9N2 avian influenza virus modulate virus fitness and virulence in chickens. This PhD studentship project was funded by Commonwealth scholarship commission for 3 years. |
| Collaborator Contribution | The collaborating Partner Dr Nicola Lewis at Royal Veterinary College is a co-supervisor of the PhD student Thusitha Karunarathna. she provide necessary guidance to achieve prescribed objectives of this project. |
| Impact | The project is at its initial stage. |
| Start Year | 2019 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Organisation | National Health Research Institutes (NHRI) Taiwan |
| Department | Institute of Molecular and Genomic Medicine |
| Country | Taiwan, Province of China |
| Sector | Charity/Non Profit |
| PI Contribution | Developed joined research project and lead successful application for funding |
| Collaborator Contribution | Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress. |
| Impact | No impact yet. |
| Start Year | 2018 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Organisation | National Institute of Genetics |
| Department | NIG-FLY, Mishima (Drosophila RNAi resources) |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Developed joined research project and lead successful application for funding |
| Collaborator Contribution | Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress. |
| Impact | No impact yet. |
| Start Year | 2018 |
| Description | DTU |
| Organisation | Technical University of Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Joint PhD studentship |
| Collaborator Contribution | Joint PhD studentship |
| Impact | Joint PhD studentship in progress |
| Start Year | 2016 |
| Description | Dr Carol Cardona, University of Minnesota- avian influenza virus challenge of IBDV or mock-infected chickens |
| Organisation | University of Minnesota |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We will challenge birds that have been exposed to IBDV, or mock exposed, with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens. |
| Collaborator Contribution | Dr Cardona's group will challenge birds that have been exposed to IBDV, or mock exposed, with low pathogenic avian influenza (LPAI) strains to determine how IBDV-mediated immunosuppression impacts upon LPAI infection in chickens. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/T008806/1) |
| Start Year | 2019 |
| Description | Dr Holly Shelton, The Pirbright Institute- avian influenza virus challenge of IBDV or mock-infected chickens |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will expose birds to IBDV, compared to mock controls |
| Collaborator Contribution | Holly will train my group in conducting studies with avian influenza viruses and, together, we will challenge birds with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/T008806/1) |
| Start Year | 2019 |
| Description | Dr Liam Morrison |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis is single cattle B cell antibody sequences |
| Collaborator Contribution | Single cattle B cell antibody sequences |
| Impact | None as yet |
| Start Year | 2019 |
| Description | Dr Lyndsay Fry |
| Organisation | Washington State University |
| Department | Washington State University Spokane |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Single B cell sorting and antibody sequencing, developing a new methods for Theileria sp. |
| Collaborator Contribution | Providing funding and the samples from immunised animals. We have also engineered an antibody to aid in the sorting of cattle B cells |
| Impact | None as yet |
| Start Year | 2019 |
| Description | Dr Michael Skinner, Imperial College London |
| Organisation | Imperial College London |
| Department | Department of Primary Care and Public Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We aim to compare the host transcriptional response of primary chicken B cells infected with different strains of IBDV of varying virulence. We have the specialist reagents and expertise in house that are required to culture primary chicken B cells, and we have access to different strains of IBDV. |
| Collaborator Contribution | Dr Michael Skinner and his team at Imperial College London have the expertise and facilities to generate and analyse RNA-Seq data in order to determine host transcriptional responses. This is required in order to complete the aim of the project. |
| Impact | Further funding: PhD studentship (£102,800) - Dr Andrew Broadbent at The Pirbright Institute and Dr Michael Skinner at Imperial College London are joint supervisors for a PhD student working on this project. Further Funding: Houghton Trust (£8,000)- Dr Andrew Broadbent was awarded a Houghton Trust Small Research Grant to contribute to this project. Further funding: NC3Rs (Grant Ref: NC/R001138/1) |
| Start Year | 2014 |
| Description | Dundee |
| Organisation | University of Dundee |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-INvestigator on BBSRC sLoLa award |
| Collaborator Contribution | Co-INvestigator on BBSRC sLoLa award |
| Impact | BBSRC sLoLa award ongoing |
| Start Year | 2012 |
| Description | Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-INvestigator on BBSRC sLoLa award |
| Collaborator Contribution | Co-INvestigator on BBSRC sLoLa award |
| Impact | BBSRC sLoLa award ongoing |
| Start Year | 2012 |
| Description | Evaluation of a PRRSV-vectored Nipah virus vaccine |
| Organisation | National Center for Genetic Engineering and Biotechnology (BIOTEC) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | Expertise in porcine immunology/vaccinology, inc. PRRSV and Nipah |
| Collaborator Contribution | Expertise in PRRSV reverse genetics |
| Impact | None as yet |
| Start Year | 2019 |
| Description | Evaluation of bovine herpesvirus-4 as a vaccine vector for pigs |
| Organisation | University of Parma |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Expertise in porcine vaccinology/immunology |
| Collaborator Contribution | Expertise in the generation of recombinant bovine herpesvirus-4 (BoHV-4) vectors expressing heterologous antigens |
| Impact | We demonstrated that immunisation of pigs with recombinant BoHV-4 vectors expressing Nipah virus glycoproteins are highly immunogenic in pigs. Most promising and as hypothesised, were the potent CD4 and CD8 T cell responses which were an order of greater than those induced by other viral vaccine vectors. These data have led to the external funding of projects by two companies to evaluate BoHV-4 vectors in the context of other porcine diseases. |
| Start Year | 2018 |
| Description | Evaluation of immune checkpoint inhibitors as molecular adjuvants for improved PRRSV vaccines |
| Organisation | Leidos |
| Country | United States |
| Sector | Private |
| PI Contribution | Expertise in PRRSV immunology |
| Collaborator Contribution | Patented immune checkpoint inhibitors |
| Impact | No yet |
| Start Year | 2019 |
| Description | Evaluation of mRNA vectored vaccines in pigs |
| Organisation | University of Pennsylvania |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Expertise in porcine immunology/vaccinology |
| Collaborator Contribution | Expertise in mRNA vaccines |
| Impact | We evaluated in pigs the immunogenicity an mRNA vector encoding a Nipah virus glycoprotein. This vaccine formulation induced high virus neutralising antibody titres (comparable with protein subunit in adjuvant) and T cell responses (comparable with viral vectors). We also utilised mRNA immunised pigs to isolate Nipah virus neutralising monoclonal antibodies. |
| Start Year | 2018 |
| Description | Evaluation of solid dose vaccines for livestock |
| Organisation | Enesi Pharma |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in PRRSV and vaccine evaluation |
| Collaborator Contribution | Expertise in vaccine formulation |
| Impact | Multidisciplinary collaboration between formulation scientist and viral immunologists. |
| Start Year | 2019 |
| Description | Genetic analysis orbiviruses |
| Organisation | University of Surrey |
| Department | Faculty of Health and Medical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Virus sequences provided for analysis. Meeting and discussion for analysis by virologist employed on this project and biomathematican at the University of Surrey |
| Collaborator Contribution | Analysis of data, training of the virologist and computational and mathematical methodology, discussion about analysis strategies |
| Impact | The collaboration is multi-disciplinary - between mathematical modelling and virology. Data analysis is still ongoing but is envisaged as preliminary data for future funding applications |
| Start Year | 2017 |
| Description | HMS |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaboration |
| Collaborator Contribution | Collaboration |
| Impact | Collaborative research |
| Description | High containment microscopy with Thermo Fisher |
| Organisation | Thermo Fisher Scientific |
| Country | United States |
| Sector | Private |
| PI Contribution | Provide advice on decontamination protocols |
| Collaborator Contribution | Development/optimisation of microscope decontamination procedures |
| Impact | No outputs yet, very early stages of collaboration |
| Start Year | 2019 |
| Description | Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Collaborator Contribution | My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Impact | Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017. |
| Start Year | 2017 |
| Description | Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. |
| Organisation | University of Kent |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Collaborator Contribution | My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Impact | Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017. |
| Start Year | 2017 |
| Description | Identification of sows with antibodies broadly neutralising PRRSV |
| Organisation | University of Lleida |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Expertise in PRRSV immunology |
| Collaborator Contribution | Access to large numbers of sows routinely vaccinated and exposed to PRRSV |
| Impact | Not yet |
| Start Year | 2019 |
| Description | Imperial |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint supervision of PhD student |
| Collaborator Contribution | Joint supervision of PhD student |
| Impact | One successful completed PhD student. Papers published or in preparation. Another PhD student in progress. |
| Start Year | 2010 |
| Description | Industrial partnership-Aviagen 2018 |
| Organisation | Aviagen Group |
| Country | United States |
| Sector | Private |
| PI Contribution | We have established a significant industrial partnership with Aviagen group Ltd. The nature of this work remains confidential. |
| Collaborator Contribution | The nature of this work remains confidential. |
| Impact | The nature of this work remains confidential. |
| Start Year | 2018 |
| Description | Interferon stimulated genes |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosted meetings and carried out preliminary experiments |
| Collaborator Contribution | Contributed reagents and expertise |
| Impact | Preliminary data was used to support an MSc project. This has since led to a publication and a PhD project. |
| Start Year | 2016 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses |
| Organisation | Royal Veterinary College (RVC) |
| Department | Veterinary Basic Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy. |
| Collaborator Contribution | provided intellectual input for achieving prescribed objectives of this work. |
| Impact | Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019. |
| Start Year | 2019 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses. |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We developed research programme to characterise diversity of antigenic epitopes induce protective immunity in chickens against H5 subtypes of avian influenza viruses. |
| Collaborator Contribution | Collaborating partner Dr Nicola Lewis at Royal Veterinary College provide advise to on cartography programme to visualize the antigenic similarity or difference among different strains of influenza viruses. |
| Impact | The work under this collaborative determined the antigenic differences among different clades of H5 avian influenza viruses circulating in birds. This project is multi-disciplinary. our laboratory mainly work on virology and immunology part of the project and we seek help on computer modeling part from the collaborating partner Dr Nicola Lewis. |
| Start Year | 2019 |
| Description | Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Shanghai Veterinary Research Institute |
| Country | China |
| Sector | Public |
| PI Contribution | Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector |
| Collaborator Contribution | Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/). |
| Impact | organised joint meeting in China and the UK to discuss on challenges and opportunities |
| Start Year | 2017 |
| Description | JN - Preparation of capped mesoporpus silica nanoparticles |
| Organisation | Polytechnic University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments |
| Collaborator Contribution | Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments. |
| Impact | Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples |
| Start Year | 2016 |
| Description | JS - Production of monoclonal antibodies that recognise FMDV VP4 from mouse spleens |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | VLPs displaying the N-terminal 15 amino acids of FMDV were designed and produced at The Pirbright Institute and then mice were immunised with them. The spleens of the immunised mice were harvested and splenocytes stored. The response to the VP4 sequence was checked by ELISA and the mouse with the best response was selected to send the splenocytes for monoclonal production. |
| Collaborator Contribution | The collaborators took the splenocytes obtained from the mouse experiments and carried out the fusions. They then screened the supernatants for positive wells that detected the VP4 sequence. |
| Impact | Positive wells have been identified indicating some monoclonals that are specific for VP4 have been generated. These will be further screened for ability to recognise virus and to neutralise infection. |
| Start Year | 2017 |
| Description | LMB |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration |
| Collaborator Contribution | Collaboration |
| Impact | Collaborative research |
| Start Year | 2016 |
| Description | Leeds FBS |
| Organisation | University of Leeds |
| Department | Leeds Institute of Molecular Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research |
| Collaborator Contribution | Research and student supervision |
| Impact | Research |
| Start Year | 2009 |
| Description | Linking sex determination and dosage compensation in a mosquito Anopheles gambiae |
| Organisation | University of Zurich |
| Department | Institute of Molecular Life Sciences |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Developed a new research program. |
| Collaborator Contribution | Provided intellectual input, contributed to drafting a joined grant proposal. |
| Impact | No output yet. |
| Start Year | 2019 |
| Description | Merial |
| Organisation | Sanofi |
| Department | Merial Plc |
| Country | Global |
| Sector | Private |
| PI Contribution | BBSRC Link award |
| Collaborator Contribution | BBSRC Link award |
| Impact | BBSRC Link award in progress |
| Start Year | 2016 |
| Description | Next-generation PRRSV vaccines |
| Organisation | Huvepharma |
| Country | Bulgaria |
| Sector | Private |
| PI Contribution | Expertise in PRRSV virology and immunology |
| Collaborator Contribution | Funding |
| Impact | Too early, project ongoing. |
| Start Year | 2019 |
| Description | Nicolas Locker - Investigation of translation regulation by infectious bronchitis virus |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team provide experience in molecular virology and cellular interactions of infectious bronchitis virus including previous experience of IBV accessory proteins regulating cellular translation. A PhD student works jointly between our labs. |
| Collaborator Contribution | Dr Locker's team provide expertise in viral regulation of cellular translation and stress granule signalling. Dr Locker is also providing protocols, advice and training for techniques including ribopuromycylation and ribosome profiling. A PhD studentworks jointly between our labs. |
| Impact | PhD student funding (studentship commenced Oct 2017) - Control of host cell translation by infectious bronchitis virus |
| Start Year | 2016 |
| Description | Novel PRRS and swine influenza vaccines |
| Organisation | National Center for Genetic Engineering and Biotechnology (BIOTEC) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | Expertise in PRRS immunology and vaccine evaluation. |
| Collaborator Contribution | Novel vaccine strains and SE Asian field strains |
| Impact | Collaborative grant proposal funded under the BBSRC Newton Fund UK-China-Philippines-Thailand Swine and Poultry Research Initiative |
| Start Year | 2017 |
| Description | Oxford - Strubi |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Collaborator Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Impact | Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging |
| Start Year | 2008 |
| Description | PRRS and Influenza co-nfection studies |
| Organisation | Government of Thailand |
| Department | National Science and Technology Development Agency (NSTDA) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | The Pirbright team of 4 scientists with expertise in immunology and animal care visited Thailand in July 2018 to train Thai colleagues to perform animal experiments (Chiang Mai) and analyse immune responses by ELISPOT and Flow cytometry (Bangkok). This provided Thailand with trained personnel and expertise in testing vaccines in pigs. As a result of the joint work, the Chiang Mai animal facility is currently being renovated. Development of such an animal facility will promote the production and testing of more vaccines by Thai scientists. |
| Collaborator Contribution | Our Thai colleagues provided us with local Thai PRRS and Influenza virus strains which we use in our co-infection studies. |
| Impact | None yet |
| Start Year | 2018 |
| Description | Partnering with National Taiwan University |
| Organisation | National Taiwan University |
| Country | Taiwan, Province of China |
| Sector | Academic/University |
| PI Contribution | We have prepared and submitted an application for a BBSRC-Taiwan Partnering Award to study "Assembly of Recombinant Infectious Bronchitis Virus and Determination of Antigenic Sites that Confer Hemagglutination Activity". |
| Collaborator Contribution | The partners conceived the project and got in contact about submitting an application for funding together. |
| Impact | An application has been made for a BBSRC-Taiwan Partnering Award in November 2018. |
| Start Year | 2018 |
| Description | Professor Helen Sang,The Roslin Institute - GFP1-10 expressing transgenic chickens |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed IBDV tagged to GFP11 |
| Collaborator Contribution | Helen Sang's group at the Roslin Institute have developed transcgenic chicken lines that constitutively express GFP1-10 in every cell. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/S014594/1) |
| Start Year | 2019 |
| Description | Protein Production UK (Formerly the Oxford Protein Production Facility) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are providing the sequences of antibodies from various species to add into the vectors at Oxford to produce species specific antibodies. We are also providing and devloping assays to measure recombinant antibody confirmation and binding. |
| Collaborator Contribution | PPUK is providing access to all their facilities as well as expertise. They are alaso providing there vector backbone as the template for antibody production |
| Impact | None as yet |
| Start Year | 2018 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Reannotation of the Anopheles gambiae genome |
| Organisation | Biomathematics and Statistics Scotland (BioSS) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development. |
| Collaborator Contribution | Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Reannotation of the Anopheles gambiae genome |
| Organisation | Centre for Genomic Regulation (CRG) |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development. |
| Collaborator Contribution | Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Reannotation of the Anopheles gambiae genome |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development. |
| Collaborator Contribution | Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Reporter PRRS viruses |
| Organisation | Kansas State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | A new application for recombinant reporter PRRS viruses i.e. to use them as a high throughput screen for neutralizing (monoclonal) antibodies. Use as tools to assess the tropism of PRRSV for dendritic cell subsets and the functional consequences. |
| Collaborator Contribution | Provision of plasmids encoding GFP-expressing PRRSV-1 and -2. |
| Impact | Not yet |
| Start Year | 2016 |
| Description | Retroviral-mediated genetic programming of porcine memory B cells |
| Organisation | AIMM Therapeutics |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Provided a novel 'model' system to test their technology to isolate novel monoclonal antibodies |
| Collaborator Contribution | To provide their patented platform technology to genetically program porcine memory B cells to enable the isolation of memory B cells |
| Impact | Not yet |
| Start Year | 2016 |
| Description | SiSaf Ltd, FMDV + carriers |
| Organisation | SiSaf Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Advice on experimental design, provision of FMDV empty capsids (Alison Burman). Will do practical work in the future. |
| Collaborator Contribution | Preparation of carrier formulations |
| Impact | No outputs. Company did not respond to proposed experimental plan. |
| Start Year | 2019 |
| Description | St Andrews |
| Organisation | University of St Andrews |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-investigator on BBSRC sLoLa |
| Collaborator Contribution | Lead-investigator on BBSRC sLoLa |
| Impact | BBSRC sLoLa ongoing |
| Start Year | 2012 |
| Description | Supply of Arthropods to External Partners |
| Organisation | APS Biocontrol |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Bern University of Applied Sciences |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Charles University |
| Country | Czech Republic |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Helmholtz Association of German Research Centres |
| Department | Helmholtz Centre for Environmental Research - UFZ |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Lancaster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Lancaster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Liverpool John Moores University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Queen's University Belfast |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Rothamsted Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Swedish University of Agricultural Sciences |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Texas A&M University-Central Texas |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Greenwich |
| Department | Natural Resources Institute Greenwich |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Greenwich |
| Department | Natural Resources Institute Greenwich |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Liverpool |
| Department | School of Veterinary Science Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Lyon |
| Country | France |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Reading |
| Department | School of Biological Sciences Reading |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Reading |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of St Andrews |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Veterinary Medicine Hanover |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | VUC Aarhus |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | A total of approximately 300000 biting midges and several tens of thousand mosquitoes were supplied as a national capability to receiving institutes. These were used in a wide range of studies from assessment of host location to teaching resources. The grant funds a Culicoides technician (100% FTE) and a mosquito technician (50% FTE) who are responsible for production. All use is acknowledged in papers arising and research is conducted under MTAs throughout held by the Pirbright IP department. |
| Collaborator Contribution | A range of scientific studies around biting midges and mosquitoes. For outputs see publications. |
| Impact | Both internal and external outputs have resulted in a clearer understanding of the risk of arbovirus incursion in the UK and additionally has contributed to the development of control techniques for vectors. Outputs also include outreach activities, student training and other societal and cultural collaborations. |
| Start Year | 2011 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Zoological Society of London |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Syngenta UK |
| Organisation | Syngenta International AG |
| Department | Syngenta Ltd (Bracknell) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | This collaboration aims to identify functional relationships between insecticide resistances in mosquitoes and competence of vector mosquitoes for arboviruses. Further, this collaboration aims at the generation of transgenic mosquitoes overexpressing proteins involved in certain insecticide resistances as tools to study the mechanism for such resistances. We have selected candidate proteins and overexpressed them in cell culture and in mosquitoes for vector competence studies as well as functional studies (insecticide uptake bioassays). |
| Collaborator Contribution | Syngenta UK has provided intellectual input into our study design and expertise in the field of insecticide resistance mechanisms. |
| Impact | No outputs yet. Collaboration between The Pirbright Institute and agrochemical industry. |
| Start Year | 2019 |
| Description | The GCRF One Health Poultry Hub |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia. |
| Collaborator Contribution | Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use. |
| Impact | Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production. |
| Start Year | 2018 |
| Description | The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV). |
| Collaborator Contribution | This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world. |
| Impact | Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020). |
| Start Year | 2020 |
| Description | Thomas Bowden - STRUBI - University of Oxford - Glycoprotein structure collaboration |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data and advice about the biological properties of viral glycoproteins, e.g. their fusion capacity with various receptors, their role in determining host-range |
| Collaborator Contribution | Advice and technical support at the structural level supporting future project development and design |
| Impact | No outcomes as yet |
| Start Year | 2018 |
| Description | Trevor Sweeney - University of Cambridge PhD Studentship |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of PhD studentship project in collaboration with Dr. Sweeney's lab at Cambridge and application at Pirbright. |
| Collaborator Contribution | Development of PhD studentship project and application at Cambridge. |
| Impact | The PhD studentship has been funded and is currently been advertised. |
| Start Year | 2018 |
| Description | University of Liverpool Proteomics Collaboration |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generation of samples to analyse the membranous proteome of cells infected with paramyxoviruses. |
| Collaborator Contribution | Proteomic analysis of samples and technical support. Access to previous data-sets and expertise. |
| Impact | Preliminary data sets only to date. |
| Start Year | 2018 |
| Description | Use of fluorescent virions to isolate PRRSV-specific porcine B cells |
| Organisation | University of Minnesota |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Deployment of a novel technology to facilitate isolation of PRRSV neutralizing monoclonal antibodies |
| Collaborator Contribution | Provision of a method to fluorescently tag purified virions to label PRRSV-specific B cells |
| Impact | None to report to date |
| Start Year | 2016 |
| Description | Wilhelm Gerner |
| Organisation | University of Veterinary Medicine Vienna |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Our lab hosted Dr Gerner who brought samples for RNA-seq. My lab planned and executed the sequencing and is contributing to the analysis. |
| Collaborator Contribution | Dr Gerner did all the animal work and cell sorting to produce the samples reading for RNA-seq |
| Impact | None as yet, analysis is ongoing |
| Start Year | 2019 |
| Description | York |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration |
| Collaborator Contribution | Collaboration |
| Impact | Collaboration |
| Start Year | 2015 |
| Title | Chicken IFITMs |
| Description | The present invention provides an avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3). |
| IP Reference | WO2014195692 |
| Protection | Patent granted |
| Year Protection Granted | 2018 |
| Licensed | Commercial In Confidence |
| Impact | The present invention provides an avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3). This patent has enabled us to leverage funding for continued work. |
| Title | CARGO: effective format-free compressed storage of genomic information |
| Description | CARGO is a compressor compiler. Given a high-level description of a file format (such as FASTQ or SAM) and compression methods for each field, it automatically generates optimized (de)compressors for such a format. Random access and range queries are provided for sorted datasets. Arbitrary sets of CARGO-compressed files can be stored together in a CARGO container. |
| Type Of Technology | Software |
| Year Produced | 2016 |
| Impact | Technical solutions derived from CARGO are being discussed for incorporation into the upcoming MPEG (Moving Picture Experts Group) standard for the compression of genomic information |
| Description | Poster presentation: International Pig Veterinary Symposium and International PRRS Symposium, Chongqing, PR China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Luke Johnson (PhD student) gave a poster presentation on his studies on the interaction of macrophages and dendritic cells with PRRSV of differing virulence. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed improving prevention and control of viral diseases of poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed prevention and control of infectious diseases affecting poultry production. |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 1st Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on "Generic approach for the development of genetic sexing strains for SIT applications" Vienna, 7-11 October 2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FAO/IAEA Coordinated Research Project on exploring genetic and molecular methods of sex separation in insect pests; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.labanimaltour.org/pirbright |
| Description | A talk at a symposium entitled: Using the 3Rs to support good science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk at a Symposium held at The Pirbright Institute entitled: "Using the 3Rs to support good science". The talk was entitled: "A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry" |
| Year(s) Of Engagement Activity | 2017 |
| Description | A talk at the British Poultry Diseases Group meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The Poultry Diseases Group meet quarterly and is comprised of representatives from private veterinary practices, vaccine and pharmaceutical industries, and the Animal and Plant Health Agency (APHA). I gave a talk at one of the meetings outlining my research to date and future directions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Amin Asfor presented the findigs of the project at the Microbiology Society Annual meeting, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amin Asfor presented the findigs of the project at the Microbiology Society Annual meeting, 2019. Title: in vivo and ex vivo models of Infectious Bursal Disease Virus (IBDV) in inbred chicken lines differing in their resistance to the disease. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Amin Asfor presented the work at the NC3Rs Fellows Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amin Asfor presented a poster at the NC3Rs Fellows Day entitled: Chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry |
| Year(s) Of Engagement Activity | 2019 |
| Description | Ash Manor GCSE Mentoring 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC Today programme 24/01/2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview on BBC Today programme regarding potential development and use of gene drives in mice |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/sounds/play/m00025bt |
| Description | BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Big Band Science Event- AH, ER, LVC, MdP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Big Bang Fair South East - RC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science festival/event - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Big Bang SE |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation (HB and MA) in Big Bang SE |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.thebigbangfair.co.uk/ |
| Description | Big Bang UK- Jennifer Simpson |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Big Bang UK is a science competition. JS acted as moderator for final projects submitted by students from across the UK. |
| Year(s) Of Engagement Activity | Pre-2006,2019 |
| Description | Blenheim High School Fair - DB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Team members attended sessions at a local high school with secondary school children and those in the 6th form to talk about paths into scientific careers, sharing their experiences of working at The Pirbright Institute. Approximately 300 students attended and it stimulated increased interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Policymakers reported greater interest in deer-associated diseases including EHDV and BTV |
| Year(s) Of Engagement Activity | 2018 |
| Description | Brownies-AH |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talking to the Brownies about science and their careers |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bull/Intel press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | The Integrative Biology and Bioinformatics group at Pirbright has acquired a bespoke computer cluster for genomics from Atos/Bull. Paolo Ribeca and Bryan Charleston were asked by Atos/Bull and Intel to contribute to a case study that illustrates the usefulness of high-performance computing in combating animal diseases and improving livestock welfare. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://globenewswire.com/news-release/2017/01/10/904852/0/en/The-Pirbright-Institute-chooses-an-Atos... |
| Description | CC Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | MA participated in a careers fair at Collingwood College |
| Year(s) Of Engagement Activity | 2019 |
| Description | CNN interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with CNN journalist. Journalist later followed up asking me to check and clarify some issues. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Camberley Library Fun Palace 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Centre of excellence for research on avian diseases (CERAD) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I was invited to present my work at the UK-China Centre of excellence for research on avian diseases (CERAD) meeting attended by researchers from UK, China and Thailand. There was lots of discussion about the research and future directions, including potential collaborations. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Chair - Royal Entomological Society Session on Insect Vectors |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on Insect Vectors including selecting speakers and managing session. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.royensoc.co.uk/sites/default/files/RES%20Ento%20'19%20Reg.%20Leaflet_web.pdf |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major national science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - RC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - SV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Display at major science festival: changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018-DP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major national science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival- AH, ER, JC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Present at the Pirbright stand to discuss science with the public |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenham Science festival - LB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | National science festival which Team members attended to demonstrate to the public how scientists at The Pirbright Institute can work to contain and control viral outbreaks. Over 500 people accessed the information and this stimulated increased interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenhan Science Festival - Dana Perry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | DP helped to run a stand at the festival, questions from the general public stimulated increased interest in science and research and increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference session organiser at MMC2017 - Host Pathogen Interactions |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities. |
| Year(s) Of Engagement Activity | 2012,2014,2015,2017 |
| Description | Coronavirus lecture MSc students (Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was presented on the replication, cellular interactions and pathogenesis of coronaviruses to 15-20 MSc students from University of Surrey. The students were engaged and interested, answering and asking questions during the session. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | DARPA visit April 2017 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Hosted visit by US funding agency programme manager to The Pirbright Institute |
| Year(s) Of Engagement Activity | 2017 |
| Description | Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Demonstrating Mathematics (Angita Shrestha) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Angita Shrestha (PhD student within Avian Influenza group) provided help in a Maths session to the new Oxford Doctoral Training Porgramme (DTP) cohort. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diamond Light Source Open day - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A public open day for Diamond Light Source, which Pirbright attended as a user of the facility to showcase research being performed at Pirbgith in collaboration with Diamond. There was a lot of interest in the fundamental research and sicussion about future plans and how it fit with the facility at Diamond. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diego Friere Pesquisa Fapesp |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with journalist leading to article regarding release of transgenic mosquitoes into the environment to control dengue and other diseases |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://revistapesquisa.fapesp.br/en/2020/02/05/jacobina-controversy/ |
| Description | Discuss gene drives with NZ Parliamentary Commissioner |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Met NZ Parliamentary Commissioner to provide background information on, and discuss, gene drive systems. New Zealand is considering genetic and other control methods for invasive pests. |
| Year(s) Of Engagement Activity | 2018 |
| Description | EM-UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-organiser and speaker for UKRI supported network for electron microscopists in the UK. I was one (or two) of the founder members. Meeting has been running for 5 years. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM-UK: A national network for electron microscopists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Founder and Chair of EM-UK, a national network (with international participants) for electron microscopists. Includes a one or two day meeting with invited speakers, and email discussion list for questions, comments, advertising courses, advertising jobs. It has proved very popular with over 200 people registering for the discussion list, and 90+ delegates at each meeting. Administration is handled by the Royal Microscopical Society. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | EMBO Workshop: Molecular and population biology of mosquitoes and other disease vectors: vector and disease control |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Sex determination pathway in Anopheles gambiae as a target for mosquito control" given during the meeting held on 22 - 26 July 2019 in Kolymbari, Greece. Following a presentation a request was made to give an informal seminar at the Department of Life Sciences, Imperial College, London. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://meetings.embo.org/event/19-mosquitoes |
| Description | Encouraging women into science and engineering STEM. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | MH Visited Warwick School, Redhill to talk to secondary students about careers in STEM. A very positive outcome and well received. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Epizone participation by team member |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Postdocteral scientist attended poster session at EPIZONE, "Breaking walls" Berlin 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi... |
| Description | Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Farnborough Sixth Form College Careers Fair - Chris Chiu |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | CC engaged at a careers day, and answered questions presented by sixth form students about working in science. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Farnborough futures careers event - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The careers event aimed to introduce the range of careers available at Pirbright. In addition I discussed my own career progression and highlighted the range of possible careers that I could have entered. Finally, I discussed some details of the research with interested students. The students had a wide range of backgrounds and career aims but were interested to hear about the Institute and the sort of work opportunities available. Several of them planned to follow up by investigating future job opportunities at Pirbright. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gene Drive Resarch Sponsors and Supporter's Forum meeting Montreal Sept 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Forum met to discuss the state of the art and future considerations for gene drive research. Ongoing deliberations including specific follow-up meetings. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Guest lecturer MSc Imaging course at University of Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Guest lecturer for PhD course in EM, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. Increase visibility of The Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans. - Avian influenza virus evolution and efficacy. - |
| Year(s) Of Engagement Activity | 2018 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Focus of the conference was to improve control against infectious diseases affecting poultry and livestock. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Holt School Surrey. Bee meadow & A-level outreach Talk. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I discussed the importance of pollinators for biodiversity and food security with the younger students. I also discussed careers in science with A-Level students. There was good interaction and many questions surrounding both topics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation (meeting 12-15 April and report) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Participated as member in Technical Subgroup on Synthetic Biology and Biodiversity Conservation of International Union for Conservation of Nature (IUCN). Meetings, online discussion and ultimately a report to Task Force and will ultimately go to IUCN General Assembly. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Imagineering Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talked to the general public about Pirbright science and Beekeeping |
| Year(s) Of Engagement Activity | 2019 |
| Description | Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dissemination of research outputs. Improvement of vaccines and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Improving vaccines and diagnostics for Avian influenza viruses affecting poultry. Presented at the International Poultry Expo "Poultry Science Conference", Lahore, Pakistan, 13-15 September 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | InFocus article (Jennifer Simpson) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | InFocus review article for EM-UK meeting (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Influenza update meeting (Pengxiang Chang) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | presented work entitled: Antigenic characterization of avian influenza H7N9 virus by in vitro immune escape mutant selection method. |
| Year(s) Of Engagement Activity | 2018 |
| Description | InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.alphavisa.com/isessah-innovsur/2018/ |
| Description | Innovate Guildford |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at Innovate Guildford science festival. Visitors to stand able to discuss issues related to animal diseases and their control (with a particular focus on influenza and on use of genetic modification technologies) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guildford (Angita Shrestha): |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | GENERAL SCIENCE |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford - DB & KC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Public science event where team members participated on a Pirbright Institute stand which contained activities to help the public understand how scientists can help to contain and control viral outbreaks. Over 500 members of the general public attended which stimulated increased interest in science and research and led to requests for more information. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford 17 March 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and exhibit at Innovate Guildford - >100 for talk, probably >500 for exhibit. Both sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.guildford.gov.uk/IG18 |
| Description | Innovate Guildford 2018 - SB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 - SV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Display at regional science/innovation festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford, ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented at the Pirbright Institute stand discussing science performed by the Institute with the general public. The stand focussed on an exhibit on avian influenza virus but more general virology topics were also discussed including our research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guilford-AH, AA, ER, EL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | General science festival engaging the public in the research undertaken at Pirbright |
| Year(s) Of Engagement Activity | 2019 |
| Description | Institute stand at Surrey Vet School open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Avian Respiratory Disease Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michael presented his research at the 2018 International Avian Respiratory Disease Conference in the US to an audience of avian researchers and representatives form the poultry veterinary vaccine industry. This sparked discussion and potential future collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | International Day of Women and Girls in Science |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a quote as a STEM ambassador about why I think it is important to make sure women and girls have the same opportunities in STEM. This was shared on social media to celebrate International Day of Women and Girls in Science, a UN-led initiative. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Chair at European Congress of Entomology (Naples,July) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ece2018.com/scientific-programme/day-1-monday-2-july/ |
| Description | Invited Lecture - Public Health Interest Group (London School Hygiene and Tropical Medicine) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk presented and discussion session particiation (09/04/19) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Lecture - Wageningen University and Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title: Culicoides-borne arboviruses in Europe - Invited lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Presentation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presentations at the European PRRS Research Award ceremonies |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Invited lecturer for MSc Biological Electron Microscopy, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited member of the Program Committee of AlCoB (Algorithms for Computational Biology) 2016 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I was invited to join the Program Committee of the Algorithms for Computational Biology conference 2016 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://grammars.grlmc.com/AlCoB2016/pc.php |
| Description | Invited member of the Program Committee of AlCoB (Algorithms for Computational Biology) 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I was invited to join the Program Committee of the Algorithms for Computational Biology conference 2018 |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://grammars.grlmc.com/AlCoB2018/pc.php |
| Description | Invited member of the Program Committee of ECCB (European Conference on Computational Biology) 2016 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I was invited to join the Program Committee of the European Conference on Computational Biology 2016 |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.ebi.ac.uk/eccb/2016/home/committees-2/index.html |
| Description | Invited oral presentation at 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral presentation: 'Trying to hit a moving target: Novel approaches to porcine reproductive and respiratory syndrome virus vaccine development', 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited presentation at the Friedrich Loeffler Institute (January; Riems) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation: 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited by the British Society for Immunology to give a presentation on vaccine research at the 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens, Berkeley, UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at INRAE, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar to present our recent and ongoing PRRSV research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited speaker - Moredun |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on Bioimaging capabilities at Pirbright to Moredun Institute. Attended by Head of Bioimaging at Roslin too, increased links between these institutes. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Invited speaker - PHE Colindale |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on high containment microscopy, asking for my advice prior to the design of a new high containment microscopy facility at PHE. This sparked a discussion at the end of the meeting, and several key points of advice that I put forward for them to consider during this process. I made it clear that I am available for other discussions at a later date if needed. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker - RMS EM School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to lecture on certain aspects of electron microscopy. I provided advice on individuals difficulties they had with sample preparation. Delegates had the opportunity to ask me any questions then had relating to any sample type. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker on "The Host-vector-pathogen Interface of Culicoides-borne Bluetongue Virus" at the VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 4th-5th December 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at APHA surveillance meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at Imperial College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on our recent research in swine influenza. Discussions with PIs at Imperial after the talk. Established collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at the British VeterinaryPoultry Association 2018 meeting at Boehringer Ingelheim |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | I was invited to present my research findings at the British Veterinary Poultry Association 2018 meeting, held at Boehringer Ingelheim. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, Vienna Veterinary School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a guest lecture at the Veterinary school in Vienna. There were a lot of questions and discussion after the talk. As a result established collaboration with Gerner Wilhelm's group. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.vetmeduni.ac.at/de/graduate-school-pig-and-poultry-medicine/ |
| Description | Invited talk at Nipah Virus International Conference, Singapore |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation on our ongoing work to develop a Nipah virus vaccine for pigs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at World Vaccine Congress, Washington DC, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed the potential for structural vaccinology to advance livestock vaccine development including examples of FMDV, bRSV and PRRSV |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited to attend and present at the RSPCA Lay members Forum, Royal Society London 10th of December 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Invited to attend to the RSPCA Lay members Forum, Royal Society London 10th of December 2018 and present on the ethical review process of animal research |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://science.rspca.org.uk/sciencegroup/researchanimals/ethicalreview/differentsystems/uk/events |
| Description | Isabelle Dietrich - Bishop David Brown School Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | >100 students attended careers fair. Informed students about The Pirbright Institute's work and career opportunities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Isabelle Dietrich - Collingwood College Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | >100 students attended careers fair. Informed students about The Pirbright Institute's work and career opportunities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Isabelle Dietrich - Talk at "Symposium on New Emerging Mosquito-Borne Diseases and Vectors", Taiwan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation, followed by questions and discussions and establishment of new collaborations. Judged poster competition. Visited collaborators' institutes to introduce The Pirbright Institute's work in general and our group's work in particular. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Isabelle Dietrich - Talk at RIVR |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation, followed by questions and discussions. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Jennifer Simpson - Big Bang Competition judge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | The Big Bang Competition recognises and rewards young people's achievements in all areas of science, technology, engineering and maths (STEM), whilst providing them with the opportunity to build their skills and confidence in project-based work. The Competition is open to all UK residents in full-time education or training. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Jennifer Simpson - Careers Fair at Woking High School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Pirbright Institute stand at the careers fair. Speak to students interested in a career in science. Sparked questions and discussions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - Girls into STEM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach activity for girls in local schools to demonstrated the variety of careers available within the STEM sector. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - InFocus article on Bioimaging in high containment |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Magazine article describing the facilities for imaging in high containment at Pirbright. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - Surrey MSc students visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Jenny organized a practical session where the students prepared their own samples for the confocal microscope, then they were able to image these samples using our instrument. The activities provoked questions and discussion. This session is always very warmly received by the students. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | Katy Moffat - Surrey MSc student visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Katy ran a small workshop for the students which enabled them to see the whole flow cytometry workflow. These activities provoke questions and discussions, and are always very warmly received. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | Keynote speaker - 89th IUVSTA Workshop, Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote seminar to 'high vacuum' community, including life scientists and physical scientists, with experience in microscopy or other high end analystical techniques. increased visibility of the Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker - Danish Virology Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was personally invited to be keynote speaker at the annual meeting of the Danish Virology Society, to talk about high containment microscopy of cell biology of host-virus interactions. The meeting was held at the State Serum Institute in Copenhagen, followed by a social evening which enabled me to add new contacts into my network. This invitation came direct from the Danish Virology Society, independent of the work I already do with the University of Copenhagen. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Kingdown School Warminster Wiltshire talk to 6th form students about career in science. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I presented my career path to the students to engage them on STEM careers. I had a good level of discussion and many questions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | LEAF open farm Sunday- JH, GM, WM, AH, KR, JS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual open farm day attended by businesses in the working in the farming industry in the Guilford area |
| Year(s) Of Engagement Activity | 2019 |
| Description | Laboratory Science Animal association (LASA) meeting in Birmingham, Invited speaker |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a presentation on the tolls we have developed to study swine influenza |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.lasa.co.uk/meetings/ |
| Description | Lecture of dynamics of vector-borne diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at Univerity of Cambridge |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020 |
| Description | Lecture on dynamics of infectious diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture as part of MSc in Veterinary Microbiology at University of Surrey |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017 |
| Description | Lecture on entereic coronaviruses to MSc Students (Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was presented on the pathology, diagnosis and detection of enteric coronaviruses, including virus replication and interaction with the host. The students were engaged and asked/answered question throughout the session. We were invited to repeat the lecture for the subsequent student intakes. |
| Year(s) Of Engagement Activity | 2015,2016,2018 |
| Description | Lorin Adams (Gordon's School Careers Fair) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lumpy Skin Disease D2R2 profile |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Provided expert opinion to the assessment (D2R2) of the risk of lumpy skin disease virus (LSDV) to the UK. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | MMC Learning Zone - invited speaker |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Microscience Microscopy Conference, speaker at the Learning Zone - specimen preparation for life sciences. Increase the visibility of Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | MMC2017 Learning Zone seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented a seminar on preparation of samples for electron microscopy to 24 MMC2017 delegates. Questions followed asking for advice on specific examples, also advice on interpretation of data and how to improve results. |
| Year(s) Of Engagement Activity | 2012,2015,2017 |
| Description | MPEG-G working group at Pirbright |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | From 27 to 29 September 2017 Paolo Ribeca organised and hosted at Pirbright an ad-hoc meeting of the MPEG working group on genome compression (MPEG-G). The meeting focused on writing and improving technical documents needed to establish the upcoming standard. Many aspects of generation, use, storage and retrieval of genomic information were discussed during the meeting, as well as technical details of compression algorithms suitable for high-throughput sequencing data. |
| Year(s) Of Engagement Activity | 2017 |
| Description | MSc student visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I hosted several MSc students from University of Surrey, discussed avian research with them and demonstrated some laboratory techniques. The students gained an understanding of academic research and laboratory work. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics |
| Year(s) Of Engagement Activity | 2018 |
| Description | Microbiology Society Annual conference (UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Poster or oral presentation at Microbiology Society annual conference, a major international event. The participants included researchers from many different areas of science. This provides a platform to promote research to a wider audience as well as discuss the key findings with experts in my own field. |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014,2015,2016,2017,2018,2019 |
| Description | Microbiology Society Annual conferences- invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Scientific talk on successful cross-species transmission of vector-borne viruses |
| Year(s) Of Engagement Activity | 2019 |
| Description | Microbiology Society Avian Focus Meeting (UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I gave a 15 minute oral presentation to an audience of around 80 people in 2016 and 2018. The audience consisted of researchers from many different scientific institutions from different areas of avian research. This was a great opportunity to present to experts in this field and gain novel insights into the project and the possible applications of my work. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Microbiology Today article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Microsoc 2018 "Structure-guided identification of a pathogen with pandemic potential" poster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a poster on our research at the MicroSoc annual meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | Mock Interview Programme Cove School- Ai, AA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants modulating avian influenza H7N9 virus antigenicity. Presented at The Microbiology Society Annual Conference 2019, 8-11 April ICC Belfast, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Munir Iqbal: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Negative Strand Virus 2018 Meeting "Structure-guided identification of morbilliviruses with zoonotic potential" Poster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented a poster on the Structure-guided identification of morbilliviruses with zoonotic potential at the international negative strand virus (NSV) meeting in Verona, Italy. |
| Year(s) Of Engagement Activity | 2018 |
| Description | New Scientist interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with New Scientist regarding genetic control of mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.newscientist.com/article/2210190-parasite-brings-down-mosquito-numbers-in-parts-of-guang... |
| Description | Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of this workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. The workshop provided information on emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I presented my work at the Nidovirus Symposium, which is held every three years and brings together researchers from industry and academia from many different countries. I had some interesting discussions with other researchers and built my network. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Organiser/invited speaker - PhD course in EM, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Outreach at TeenTech Events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | TeenTech runs lively initiatives with a supporting Award scheme to help young teenagers see the wide range of career possibilities in Science, Engineering and Technology. They work collaboratively with companies, Universities, business organisations and education business partnerships to build sustainable and imaginative programmes focussing on regions of greater social need in the UK and Europe. This outreach actvity involved primarily school children aged 12/13. Several hundred attended and our attendees (Laura Tugwell) spoke with about 30-40 children/teachers. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.teentech.com/ |
| Description | PacBio Leiden |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presented data to academics and industry experts on the methods we have developed to enrich and sequence targeted areas of genomes |
| Year(s) Of Engagement Activity | 2018 |
| Description | Participation in a meeting regarding sex determination, Duesseldorf, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Sex determination pathway in Anopheles gambiae as a target for mosquito control" during the Nothiger meeting on sex determination in insects, Duesseldorf, 11-13 March 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pengxiang Chang: Talk presentation:The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines at Microbiology Society conference, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of vaccines to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://microbiologysociety.org/event/annual-conference/annual-conference.html |
| Description | Pengxiang Chang: UK-China Newton Fund (Poultry and swine) workshop at The Pirbright Institute.Oral presentation:Avian Influenza H7N9 Antigenic markers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pengxiang Chang:Influenza update meeting. The application of CRISPR/Cas9 in the development of vaccines against avian influenza virus |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques to improve and produce new effective vaccines against viral diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | PhD course in Electron Microscopy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Intensive workshop containing lectures and practicals in the use of electron microscopy in life sciences. This takes place every year at the University of Copenhagen, I am a course organizer and invited speaker. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017 |
| Description | Pig and Poultry Fair 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussed Institute research with pig and poultry farmers, related industry and the general public. Received requests for more information related to research, business and studentships. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pigandpoultry.org.uk/ |
| Description | Pirbright Dragon Fair - MZ |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Team members attended the locally held Dragon fair where the Pirbright Institute had a stand explaining the types of research that are conducted at the Institute, making our high containment science activities transparent to the local community. Approximately 60 people engaged with the stall to learn about the science happening on their doorstep. This stimulated interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Plenary speaker - Electron Microscopy Cryo-techniques as Tools for Elucidating Biological Processes, University of Minas Gerais, Brazil |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was personally invited to talk about imaging the cell biology of host-virus interactions. I was available throughout the associated workshop to provide advice on delegates projects relating to microscopy. These talks sparked discussions and more questions. I was able to increase my network of connections further during this visit to Brazil. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Population Biology of Vector-Borne Diseases Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Postdocteral scientist - oral presentation at the 12th Annual meeting of Epizone (joint with 11th International Congress for Veterinary Virology, ESVV 2018) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Postdoctoral scientists abstract submission was selected for oral presentation. Project results obtained at the time were presented to a highly interested and engaging audience of more than 250 scientists, veterinarians, students and policymakers. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.epizone-eu.net/en/Home/News/show/Abstract-book-EPIZONEESVV-meeting-now-online-.htm |
| Description | Postdoctoral researcher Stacey Human talk at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stacey presented her data on examining the cellular processes involved in trafficking RSV components to the cell surface. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presentation: European Veterinary Immunology Workshop, Utrecht, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Luke Johnson (PhD student) gave a poster presentation on his studies on the interaction of macrophages and dendritic cells with PRRSV of differing virulence. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Poster presentation: European Veterinary Immunology Workshop, Utrecht, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | David Goldeck (post-doctoral scientist) gave a poster presentation on our studies to isolate PRRSV-neutralising monoclonal antibodies from immune pigs. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Poultry Stakeholders meeting hosted by Almarai, 15 October 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engagement with Almarai Poultry. The focus of the meeting with Almarai Poultry disease control team was to share knowledge on improved vaccination and diagnostic techniques against avian influenza viruses affecting poultry production. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poultry Stakeholders meeting in Kuwait city 16 October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prevention and control of avian influenza outbreaks in poultry. Described new vaccination and diagnostic technologies that provide more robust cross-protective immunity in emerging antigenic divergent strains of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Practical training given to LSHTM MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Two-hour practical teaching session given to 12 MSc students at the London School of Hygiene and Tropical Medicine (LSHTM) on 17th November 2017 (Lara Harrup). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at Avian viruses focussed meeting - Sept 2018 ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data as an offered paper at the molecular biology and pathogenesis of avian viruses meeting, Oxford Sept 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Global Alliance for Research on Avian Diseases Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of my research at the Global Alliance for Research on Avian Diseases Conference in Vietnam to approximately 80 conference participants resulted in discussions about future research directions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Inter-institute Bioimaging networking meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | An event was held to enable improved collaboration opportunities between scientists working with bioimaging techniques at the different research institutes within the UK. I presented data from the last 10 years describing our work characterising replication organelles induced by IBV, describing the different techniques and approaches we have used and the outlook for the future. The talk aimed to showcase the bioimaging facilities at Pirbright to encourage new collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at RIVR meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation of my work to other researchers at the Recently Independent Virology Researchers meeting. I discussed my data with other researchers and potential for future collaboration. |
| Year(s) Of Engagement Activity | 2016,2017,2019,2020 |
| Description | Presentation at RIVR meetings |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of my research at Recently Independent Virology Researchers (RIVR) meetings in 2016, 2017, 2018 and 2019. I discussed my work and future collaborations with other virology researchers working in the UK. |
| Year(s) Of Engagement Activity | 2016,2017,2018,2019 |
| Description | Presentation at Translation UK 2019 - MJB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster presnetation of data to scientistis at the annual Translation UK meeting. Viewers of the poster asked lots of questions and there were some useful discussions around future plans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at the EU BTV reference laboratory meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation of BTV pathogenesis and effects of Culicoides saliva to representatives from all European reference laboratories plus some additional participants from the EU and industry |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation by ND at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The post-doctoral researcher presented our data at the 14th international Nidovirus symposium. She discussed data and potential collaboration with other scientisits from the field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation by RH at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | PhD student presented our data at the 14th international Nidovirus symposium. He discussed results and potential for future collaboration with other scientists in the field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation of data at Microbiology Society Annual conference 2019 - MJB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation of data to scientists at the Annual Microbiology Society conferene, Belfast. After the presentation there were questions and disussion. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation of data at Microbiology Society Annual conference 2019 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data to scientists at the annual Microbiology Society Conference, Belfast. Following the presentation there were questions and discussion with other scientists. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation to BBSRC Executive Board |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | I presented our research to the BBSRC Executive Board when they visited The Pirbright Institute in September 2018 and discussed the impacts of our work.. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Project close meeting at TANUVAS, Chennai July 2018- Delivering talk on outcome of the project |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The project team held their final workshop at TANUVAS, which concluded a four year Farmed Animal Disease and Health (FADH) grant joint funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Indian Government's Department of Biotechnology (DBT). "This grant has enabled us to collaborate with four organisations across India, and ensured that our research can be applied in the field to aid the campaign for PPR global eradication", said Professor Parida.The project covered many areas of research which are essential for understanding PPR and creating tools to help control and prevent the disease. The team have now filed a patent application for their newly developed PPR vaccine, which is the first to differentiate between vaccinated and infected animals (DIVA) - a quality that enables livestock owners to protect their animals whilst continuing to trade. The team have also investigated how the PPR virus (PPRV) infects sheep and goats and how their immune systems respond. By inserting green fluorescent protein into virulent PPRV and administering the modified virus to goats, they demonstrated that PPRV primarily infects the tonsils, challenging the earlier belief that the virus first replicates in the respiratory tract epithelial cells. The collaborative project has also generated better diagnostic tests for use in the field and laboratory, and preliminary research has identified why some Indian breeds of goats and sheep are resistant to the disease, which could help scientists to create PPRV resistant breeds in the future. Project partners, scientists from the University and 40 field veterinarians have joined the meeting. An awareness training has been conducted on PPR disease and eradication for these field veterinarians. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes... |
| Description | Protecting poultry from avian influenza through passive immunisation. Presented at Foreign Experts Seminar "New strategies and new tools for the prevention and control of major poultry diseases. Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 20-22 September 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Q&A statement on coronaviruses provided to Science Media Centre - HJM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A Q&A statement on coronaviruses was provided to the science media centre, who distributed it to media outlets. Excerpt have been used in 1420 articles incuding the Daily Mail and syndicate articles. The Q&A was also used in a Pirbright Institute media statment. |
| Year(s) Of Engagement Activity | 2020 |
| Description | RMS EM school - invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Royal Microscopical Society Electron Microscopy School, lecture in biological sample preparation for transmission electron microscopy. Lots of questions from delegates. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rebecca Daines: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza. Presented at Systems Immunology Workshop: Adaptive immune repertoires and beyond. 16th-17th January 2020. University of Surrey, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled "Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza" was presented at the workshop exploring new technical advances for analysis and production of antibodies for prophylaxes and treatment of animal and humans diseases. Both academics and staff linked with animal and public health industry attended this workshop. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Research assistant Nazia Thakur talk at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nazia presented her data on the development of low containment assays to monitor the humoral response to vaccines |
| Year(s) Of Engagement Activity | 2019 |
| Description | Respond to SMC enquiry re gene drives in mice |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Responded to Science Media Centre request for expert comment on a scientific paper regarding gene drives in mice. Quoted in The Independent |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.independent.co.uk/news/science/gene-editing-dna-technology-mice-pests-drives-invasive-sp... |
| Description | Respond to SMC request re Vosshall paper 08 Feb 2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Respond to SMC request re scientific paper describing behaviour-altering drugs in mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| Description | Reverse genetics seminar to MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A seminar was presented describing reverse genetics of viruses, including infectious bronchitis virus and the application of reverse genetics in research. The students were interested and engaged, participating in activities and asking questions. We were invited to present the seminar in subsequent years for new student intakes. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016,2018,2019 |
| Description | Royal Institution Christmas Lectures Family Day - LA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Six Pirbright staff/students ran an all-day exhibit on gene editing and mosquitoes at the Royal Institution About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Institution Christmas Lectures Family Day - SB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | SATRO Mentoring Scheme Ash Manor School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Fortnightly mentoring activity for student's soft skill and career development. |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | SMBE 2018 meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Phylogenetically young genes and their function in Anopheles mosquitoes" given during the Society for Molecular Biology and Evolution 2018 meeting (8-12 July 2018) in Yokohama, Japan. Discussions held with potential collaborators on joined future research projects. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.smbe2018.jp/ |
| Description | STEAMfest - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A large open day event at hosted at University of Surrey for students from a number of schools in the region to explore different scientific questions and areas of work. |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEAMfest - HS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Team members attended the event where a flu fighters stand was displayed demonstrating how scientists are working to rapidly detect and control avian influenza in the filed to protect food security, animal welfare and human health. Approximately 200 secondary school students engaged with the stall and this stimulated increased interest in science and research, |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEM Day - Speed interviews and Careers Day 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | School Visit (Woking) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Amin Asfor engaged with Six-form students and parents at a Careers day. He showcased The Pirbright Institute and a Science career, discussed the use of animals in research and the need to do research aimed at reducing their use and replacing them with alternative methods. |
| Year(s) Of Engagement Activity | 2019 |
| Description | School Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Participated (AES) in Workshop at local school |
| Year(s) Of Engagement Activity | 2019 |
| Description | School careers-Big Interview MdP |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating interest in science and research to secondary school students |
| Year(s) Of Engagement Activity | 2019 |
| Description | School visit (Farnborough) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed various aspects of scientists' work. |
| Year(s) Of Engagement Activity | 2018 |
| Description | School visit (Tillingbourne) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about role of insects in the environment; guided students in collection of insects and other invertebrates, and identification of collected material. |