📣 Help Shape the Future of UKRI's Gateway to Research (GtR)

We're improving UKRI's Gateway to Research and are seeking your input! If you would be interested in being interviewed about the improvements we're making and to have your say about how we can make GtR more user-friendly, impactful, and effective for the Research and Innovation community, please email gateway@ukri.org.

Building Robustness in Crops: Exploiting the complexity of gene regulation in crops

Lead Research Organisation: John Innes Centre
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

In Work Package (WP) 2 will provide mechanistic understanding of how genes regulate phenotypic traits and will thus enable the design of improved alleles to facilitate the control of important crop traits such as vernalisation and reproduction. A major challenge to predict and improve crop traits is understanding how gene output is regulated as plants adapt to changing external environments. In the previous GEN ISP we have discovered that chromatin-regulating factors and non-coding RNAs underlie many gene regulatory events during plant development and environmental responses. However the molecular mechanism by which these non-coding pathways regulate gene transcription and translation and how they are controlled in changing external environments are still largely unclear. Elucidating these mechanisms will have immense impact on improving crop yield by controlling vital processes such as flowering time fertility photosynthetic capacity and the circadian clock and to develop tools that will aid in transgene stability. Moreover the polyploid nature of many crops provides yield benefits over diploid relatives in terms of for example vigour and organ size and understanding the mechanisms by which individual homeologue expression is controlled will facilitate the ability to predict trait outcomes. In this work package we aim to dissect the mechanistic basis of chromatin-based gene regulation and its environmental modulation. The results directly link to WP 4 providing solutions to improve crop sustainability and resilience to abiotic stresses such as drought and heat. We will take a multiscale approach from studying single gene loci and gene clusters to the interactions within and between nuclear and plastid genomes and employ multidisciplinary approaches such as machine learning single-cell and single-molecule sequencing and cryogenic electron microscopy. Through these studies we will be able to precisely predict and edit gene output and crop traits.

Planned Impact

unavailable

Publications

10 25 50
 
Description Commercialisation licensing agreement - vitamin B12 fortified pea shoots
Geographic Reach National 
Policy Influence Type Contribution to new or improved professional practice
 
Description Contributed to a Defra/JIC conference with the Animal and Plant Health and Welfare Directorate
Geographic Reach National 
Policy Influence Type Contribution to new or improved professional practice
 
Description Grant Writing workshop
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Grant writing
 
Description Member of the Food Standards Agency Advisory Committee on Novel Foods and Processes and their PGT sub-group. Ongoing.
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
Impact Contribution to the regulatory framework for products of precision breeding technologies
 
Description Took part in workshop with ARIA (Advanced Research and Invention Agency to further programme on food security and climate change
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
 
Description Training at PlantEd Transformation and Genome Editing Training School
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Enabled international participants to undertake genome editing in their home countries to improve crop development and food security.
 
Description A Platform to Rate Organisms Bred for Improved Traits and Yield (PROBITY)
Amount £1,568,698 (GBP)
Funding ID 10097973 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 06/2024 
End 06/2027
 
Description BBSRC Responsive Mode - Defining the molecular basis of chloroplast transcription of photosynthetic genes
Amount £823,548 (GBP)
Funding ID BB/Y003802/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2024 
End 05/2027
 
Description Grants for Exceptional Researchers
Amount £25,000 (GBP)
Organisation Gatsby Charitable Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2023 
End 04/2024
 
Description Light, temperature and circadian clock signal integration during leaf senescence
Amount £193,111 (GBP)
Funding ID BB/X014711/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2024 
End 01/2027
 
Description Light, temperature and circadian clock signal integration during leaf senescence
Amount £743,976 (GBP)
Funding ID BB/X014711/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2024 
End 12/2026
 
Description Mechanistic basis of nucleation and spreading underlying a Polycomb-mediated epigenetic switch (EPISWITCH)
Amount € 2,100,000 (EUR)
Funding ID 833254 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 08/2019 
End 09/2024
 
Description Predicting plant growth in naturally fluctuating conditions
Amount £306,747 (GBP)
Funding ID BB/Y513945/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2024 
End 12/2025
 
Description Predicting plant growth in naturally fluctuating conditions
Amount £253,562 (GBP)
Funding ID BB/Y513945/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2024 
End 02/2026
 
Description Royal Society Research Grants 2019
Amount £19,734 (GBP)
Funding ID RGS\R2\222157 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2022 
End 10/2023
 
Description Royal Society Research Professorship
Amount £114,859,637 (GBP)
Funding ID RSRP\R\231006 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2023 
End 03/2028
 
Description The Bacillus subtilis circadian clock: from molecules to mutualism
Amount € 8,301,946 (EUR)
Funding ID 101166968 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 03/2025 
End 03/2031
 
Description The Bacillus subtilis circadian clock: its metabolic regulation and crosstalk with plants
Amount £741,149 (GBP)
Funding ID BB/Z516636/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2025 
End 12/2027
 
Description UKRI Future Leaders Fellowship - Structure and function of the chloroplast transcription machinery
Amount £1,914,136 (GBP)
Funding ID MR/X033481/1 
Organisation United Kingdom Research and Innovation 
Sector Public
Country United Kingdom
Start 04/2024 
End 04/2028
 
Description University Research Fellowship
Amount £1,829,894 (GBP)
Funding ID URF\R1\241271 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2024 
End 10/2032
 
Title APRF1 proteomic interactors and polyadenylation sites 
Description The CPSF phosphatase module links transcription termination to chromatin silencing bioRxiv 2023.07.06.547976. To find protein partners of APRF1, we immunoprecipitated APRF1-3xFLAG and undertook proteomics - with the APRF1-FLAG proteomics deposited at PRIDE code: PXD049114). We also determined the polyadenylation sites in ColFRI, aprf1-9FRI, Col-0, and fld-4, with quant-seq also deposited at SRA code: PRJNA978558. 
Type Of Material Database/Collection of data 
Year Produced 2024 
Provided To Others? Yes  
Impact Further understanding on the link between RNA 3' processing/termination & delivery of chromatin modifications to repress further transcription 
 
Title ChIP-seq raw data for VEL proteins 
Description For Distinct accessory roles of Arabidopsis VEL proteins in Polycomb silencing. Genes & Dev PMC7615239 In this work we mapped the chromatin association of the Arabidopsis thaliana proteins VIN3 and VRN5 and investigated how their distinct roles confer PRC2-mediated epigenetic silencing in the Arabidopsis genome. The ChIP-seq raw data generated in this study has been deposited in the Sequence Read Archive (SRA) under project number PRJNA973989. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
Impact This helps the exploration of Polycomb silencing in the Arabidopsis genome 
 
Title Dataset on genome wide circadian gating of temperature responses in bread wheat 
Description The dataset arose from a study of the circadian gating of cold temperature responses in bread wheat. This comprises a large time-series transcriptomic dataset that has been made available for reuse. The data are deposited at the European Nucleotide Archive as accession PRJEB56923. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
Impact It is too early to know how others might be using the data. 
URL https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010947
 
Title MERFISH dataset in wheat inflorescence tissue 
Description Spatial transcriptomics viewer for 200 genes expressed in developing wheat inflorescences across four developmental timepoints. 
Type Of Material Database/Collection of data 
Year Produced 2024 
Provided To Others? Yes  
Impact Others have adopted methods and used data in publications 
URL https://www.wheat-spatial.com/
 
Title Sequencing data for in vivo COOLAIR structural analysis 
Description For In vivo single-molecule analysis reveals COOLAIRRNA structural diversity. Nature PMC9452300 The sequencing data on COOLAIR RNA structures and control RNA structures, e.g., 18S rRNA, HIV and other RNA riboswitches have been deposited in the Sequence Read Archive (SRA) under BioProject ID number PRJNA749291. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
Impact PacBio sequence data for COOLAIR isoforms subjected to DMA accessibility analysis will help understand the functional significance of RNA structure 
 
Title Structural model of the plastid-encoded RNA polymerase transcription elongation complex 
Description Single particle cryo-EM dataset for the structural basis of transcription in the plant chloroplast doi.org/10.2210/pdb8RDJ/pdb https://www.emdataresource.org/EMD-19023 https://www.ebi.ac.uk/empiar/EMPIAR-12279/ 
Type Of Material Database/Collection of data 
Year Produced 2024 
Provided To Others? Yes  
Impact Dataset revealed the structural basis of chloroplast transcription in plants; data relevant to selecting for, or engineering, improved photosynthetic capacity of crops for agriculture and biotechnology. 
URL http://doi.org/10.2210/pdb8RDJ/pdb
 
Description 10 Pangenome Project 
Organisation University of Saskatchewan
Country Canada 
Sector Academic/University 
PI Contribution Collaboration for 10 pangenome project
Collaborator Contribution Collaboration for 10 pangenome project
Impact Sequencing of 10 wheat varieties
Start Year 2017
 
Description Biomolecular condensates regulating Arabidopsis FLC 
Organisation University of York
Department Department of Physics
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Geng-Jen Jang generated all the gene fusions and transgenic lines expressing each fusion at endogenous protein levels. He also did initial characterization on confocal microscopes at John Innes Centre, and performed molecular analysis to investigate the RNA-protein interactions and protein-protein interactions driving condensate formation.
Collaborator Contribution Prof Mark Leake and his post-doctoral fellow Dr Alex Payne-Dwyer analysed the plant samples we sent using a modified Slimfield microscopy. SlimVarA can enhance the image contrast in complex multicellular samples that are several tens of microns deep to enable the quantification of the molecular stoichiometry and dynamic spatial localization of functional molecular assemblies on a nanoscopic length scale. Such single-molecule sensitivity combined with stepwise photobleaching was then be used to obtain the number of molecules in the FCA, VIN3 and VRN5 assemblies.
Impact Publications will be the main outcome of this collaboration
Start Year 2019
 
Description CEPAMS 
Organisation Center for Excellence in Molecular Plant Sciences
Country China 
Sector Academic/University 
PI Contribution Direct CEPAMS, a partnership between John Innes Centre and CAS, China. Manage the 16 CAS funded JIC PLs in Beijing and Shanghai, enhancing strong scientific UK-China collaborations.
Collaborator Contribution Research and development.
Impact Regular meetings, research and translational projects and publications. A newsletter. Plant and microbial biology centre.
Start Year 2014
 
Description CGIAR 
Organisation International Center for Agricultural Research in the Dry Areas
Country Syrian Arab Republic 
Sector Charity/Non Profit 
PI Contribution Provide molecular markers for yellow rust and blast resistance genes; provide germplasm with improved traits.
Collaborator Contribution provide field phenotyping and delivery into wheat cultivars
Impact n/a
Start Year 2013
 
Description CGIAR 
Organisation International Centre for Maize and Wheat Improvement (CIMMYT)
Country Mexico 
Sector Charity/Non Profit 
PI Contribution Provide molecular markers for yellow rust and blast resistance genes; provide germplasm with improved traits.
Collaborator Contribution provide field phenotyping and delivery into wheat cultivars
Impact n/a
Start Year 2013
 
Description Collaboration with Electron Bioimaging Centre (eBIC) 
Organisation Diamond Light Source
Department Electron Bio-Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples of chloroplast gene expression complexes prepared by the Webster Group at JIC are imaged with a Titan Krios cryo-TEM by collaborator Vinod Vogirala at Electron Bioimaging Centre (eBIC, Harwell). Data processing, structural model construction, data interpretation and preparation of manuscripts are performed by the Webster Group at JIC.
Collaborator Contribution Imaging of samples with a Titan Krios cryo-TEM by collaborator Vinod Vogirala at Electron Bioimaging Centre (eBIC, Harwell)
Impact 10.1016/j.cell.2024.01.036
Start Year 2022
 
Description Collaboration with Kyoto University on using AI approaches to investigate circadian time-series 
Organisation University of Kyoto
Country Japan 
Sector Academic/University 
PI Contribution Contribution of experimental work, expertise, data analysis, manuscript writing.
Collaborator Contribution Contribution of experimental work, expertise, data analysis, field site access, manuscript writing.
Impact No specific outputs from this new project yet.
Start Year 2023
 
Description Collaboration with LMU (Munich) 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution Investigation of the circadian clock in Bacillus subtilis. The Dodd team is contributing data, methods, analytical approaches, data interpretation and paper writing.
Collaborator Contribution Investigation of the circadian clock in Bacillus subtilis. The LMU team is contributing data, methods, analytical approaches, data interpretation and paper writing.
Impact A variety of publications: https://doi.org/10.1126/sciadv.adh1308 https://doi.org/10.1186/s12915-022-01443 https:/doi.org/10.1126/sciadv.abe2086 doi:10.3390/biology8020041
Start Year 2010
 
Description Collaboration with Leiden University 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution The collaboration is investigating the circadian clock in Bacillus subtilis. The Dodd team contributes data, data analysis, data interpretation and manuscript writing.
Collaborator Contribution The collaboration is investigating the circadian clock in Bacillus subtilis,. The Leiden--based team contributes data, data analysis, cell strains, data interpretation and manuscript writing.
Impact Publication of a variety of papers: https://doi.org/10.1126/sciadv.adh1308 https://doi.org/10.1186/s12915-022-01443 https:/doi.org/10.1126/sciadv.abe2086 doi:10.3390/biology8020041
Start Year 2010
 
Description Collaboration with Quadram Institute Bioscience 
Organisation Quadram Institute Bioscience
Country United Kingdom 
Sector Academic/University 
PI Contribution The project has developed approaches for fortifying salads with vitamin B12. The Dodd lab is contributing expertise in plant physiology and development to the collaboration, including the transfer of the approaches to the commercial sector.
Collaborator Contribution The project has developed approaches for fortifying salads with vitamin B12. The Warren lab at Quadram Institute Bioscience is contributing expertise in analysis, quantification and metabolism of vitamin B12 to the project, and developing a certification mark for commercial deployment of the approaches developed.
Impact Current outputs are governed by confidentiality agreements.
Start Year 2022
 
Description Collaboration with UC Santa Cruz 
Organisation University of California, Santa Cruz
Country United States 
Sector Academic/University 
PI Contribution Contribution of data concerning circadian rhythms in plants to a broader investigation of circadian entrainment across living organisms
Collaborator Contribution Conception and coordination of investigation of circadian entrainment across living organisms
Impact No outputs yet, work is still in progress
Start Year 2022
 
Description Collaboration with University of Birmingham 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Epigenetic and phenotypic characterization in wheat.
Collaborator Contribution Expertise in epigenetics.
Impact Work is still in progress so no outputs yet.
Start Year 2019
 
Description Collaboration with Vanderbilt University 
Organisation Vanderbilt University
Country United States 
Sector Academic/University 
PI Contribution Contribution of writing and data analysis leading to a collaborative publication on circadian clock evolution: doi.org/10.1177/0748730423121920
Collaborator Contribution Contribution of writing and data analysis leading to a collaborative publication on circadian clock evolution: doi.org/10.1177/0748730423121920
Impact doi.org/10.1177/0748730423121920
Start Year 2022
 
Description Collaboration with the University of Bristol 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution The BBSRC responsive mode-funded project is investigating the role of the circadian clock, light signalling and temperature signalling in leaf senescence. The project has just started, and its aim is to use discovery science to understand how short light treatments can be used to extend the shelf life of salads. The Dodd lab at JIC is contributing the circadian biology aspects of the project.
Collaborator Contribution The BBSRC responsive mode-funded project is investigating the role of the circadian clock, light signalling and temperature signalling in leaf senescence. The project has just started, and its aim is to use discovery science to understand how short light treatments can be used to extend the shelf life of salads. The Franklin lab at the University of Bristol is contributing the light signalling aspects of the project.
Impact So far, no specific outputs from this new project.
Start Year 2023
 
Description Dissecting DNA methylation dynamics in Arabidopsis 
Organisation Institute of Science and Technology Austria
Country Austria 
Sector Academic/University 
PI Contribution My team has developed detailed mathematical models of DNA methylation dynamics. The complexity of the feedback processes involved means that without this modelling the experimentally observed epimutation dynamics are impossible to properly interpret.
Collaborator Contribution My experimental partners (Zilberman group, IST, Austria) have provided the data on which the model is based and validated model predictions.
Impact Multidisciplinary collaboration. My team: mathematical/biophysical modelling; Zilberman group: experimental approaches. Millennia-long epigenetic fluctuations generate intragenic DNA methylation variance in Arabidopsis populations A Briffa, E Hollwey, Z Shahzad, JD Moore, DB Lyons, M Howard, D Zilberman Cell Systems 14 (11), 953-967. e17 Concepts, mechanisms and implications of long-term epigenetic inheritance E Hollwey, A Briffa, M Howard, D Zilberman Current Opinion in Genetics & Development 81, 102087 Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons DB Lyons, A Briffa, S He, J Choi, E Hollwey, J Colicchio, I Anderson, X Feng, M Howard, D Zilberman Cell Reports 42 (3)
Start Year 2018
 
Description Dissecting crossover specification dynamics in Arabidopsis 
Organisation University of Cambridge
Department Department of Plant Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution My team has provided mathematical modelling of HEI10 dynamics that specify crossover positions via a coarsening mechanism
Collaborator Contribution The Henderson group in Cambridge has provided over and under-expression lines for HEI10 that have helped test model predictions.
Impact Multidisciplinary collaboration. My group mathematical modelling, Henderson group experimental investigation Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis C Morgan, JA Fozard, M Hartley, IR Henderson, K Bomblies, M Howard Nature communications 12, 4674
Start Year 2019
 
Description EIAR 
Organisation Ethiopian Institute of Agricultural Research
Country Ethiopia 
Sector Academic/University 
PI Contribution We are currently sequencing 200 teff genomes
Collaborator Contribution They have provided access to germplasm and DNA
Impact none so far
Start Year 2020
 
Description KWS 
Organisation KWS UK
Country United Kingdom 
Sector Private 
PI Contribution Genetics and genomics
Collaborator Contribution Breeder know how and germplasm
Impact joint projects
Start Year 2009
 
Description Linking transcription termination to delivery of inactive chromatin 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Genetics and molecular data on transcription-coupled chromatin silencing of the Arabidopsis FLC gene
Collaborator Contribution Structural expertise on complexes mediating transcription termination and polyadenylation
Impact Submitted publication
Start Year 2022
 
Description Nuclear organization at FLC 
Organisation Uppsala University
Country Sweden 
Sector Academic/University 
PI Contribution We are supplying the mechanistic information on FLC regulation
Collaborator Contribution Dr Stefanie Rosa is continuing work started as a post-doc in Norwich, to determine changes in FLC nuclear position at different phases of the epigenetic silencing process
Impact Several publications
Start Year 2020
 
Description Partnership with NISD and UEA on future climate scenarios for break crops 
Organisation University of East Anglia
Country United Kingdom 
Sector Academic/University 
PI Contribution Discussions underway to inform research programme understanding the climate, soil and financial influences on growing a range of break crops in the UK
Collaborator Contribution Modelling work, GIS, mapping and correlating datasets. Discussions
Impact N/A
Start Year 2023
 
Description RAGT 
Organisation RAGT Seeds
Country United Kingdom 
Sector Private 
PI Contribution Genetics and genomics
Collaborator Contribution Wheat germplasm and know how
Impact Shared projects
Start Year 2009
 
Description Teff genomics 
Organisation Aberystwyth University
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on teff genomics
Collaborator Contribution Provided germplasm and genome sequences
Impact teff community workshop in March 2024
Start Year 2022
 
Description Teff genomics 
Organisation International Livestock Research Institute (ILRI)
Country Kenya 
Sector Charity/Non Profit 
PI Contribution Collaboration on teff genomics
Collaborator Contribution Provided germplasm and genome sequences
Impact teff community workshop in March 2024
Start Year 2022
 
Description Teff genomics 
Organisation King Abdullah University of Science and Technology (KAUST)
Country Saudi Arabia 
Sector Academic/University 
PI Contribution Collaboration on teff genomics
Collaborator Contribution Provided germplasm and genome sequences
Impact teff community workshop in March 2024
Start Year 2022
 
Description Teff genomics 
Organisation Sant'Anna School of Advanced Studies
Country Italy 
Sector Academic/University 
PI Contribution Collaboration on teff genomics
Collaborator Contribution Provided germplasm and genome sequences
Impact teff community workshop in March 2024
Start Year 2022
 
Description Teff genomics 
Organisation University of Cambridge
Department Department of Plant Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on teff genomics
Collaborator Contribution Provided germplasm and genome sequences
Impact teff community workshop in March 2024
Start Year 2022
 
Description Teff genomics 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on teff genomics
Collaborator Contribution Provided germplasm and genome sequences
Impact teff community workshop in March 2024
Start Year 2022
 
Description The study of polymerization domains and their role in epigenetic memory 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Academic/University 
PI Contribution Functional testing of role of polymerization domain in plant epigenetic memory
Collaborator Contribution Crystal structure of Arabidopsis VEL domains by Mariann Bienz's lab at MRC LMB
Impact Several publications
Start Year 2019
 
Description Tillering 
Organisation University of Warwick
Country United Kingdom 
Sector Academic/University 
PI Contribution knowledge on wheat genomics and genetics
Collaborator Contribution germplasm for branching
Impact Field trials and manuscript in preparation
Start Year 2022
 
Title Single-molecule RNA structure profiling 
Description Method for profiling single-molecule RNA structure at the nucleotide resolution. 
IP Reference  
Protection Patent / Patent application
Year Protection Granted 2024
Licensed No
 
Title MERFISH dataset in wheat inflorescence tissue 
Description This spatial transcriptomics resource features MERFISH data from a 200-gene panel targeting wheat inflorescence tissues of hexaploid bread wheat (cv 'Paragon'). 
Type Of Technology Webtool/Application 
Year Produced 2024 
Impact Others have used and cited in publications. 
URL https://www.wheat-spatial.com/
 
Company Name Rnashield Limited 
Description RNA Shield develops RNA structure-based antivirals to provide environmentally-friendly protection against plant viruses. 
Year Established 2023 
Impact This will provide an alternative to the now banned neonicotinamide insecticides that targeted the viral vector, the peach potato aphid. This work received additional financial support during the reporting period through a £50K Royal Society award for commercialisation.
Website https://rnashield.co.uk/
 
Description BBSRC impact case study 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact BBSRC prepared an impact case study that summarised this project that has developed salad products that are fortified with vitamin B12. The impact case study emphasised the benefits of collaboration within the Norwich Research Park (between JIC and QIB), and also with industry partners. The impact case study also demonstrated how several different lines of BBSRC funding led up to the award of a Follow on Fund grant that has ultimately supported the commercialisation of this product.
Year(s) Of Engagement Activity 2025
URL https://www.ukri.org/who-we-are/how-we-are-doing/research-outcomes-and-impact/bbsrc/supplement-salad...
 
Description Biophysics and Biology workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Zoe Waller and Dr Yiliang Ding organized a two-day workshop on biophysics and biology that promote the scientific communications between Norwich Research Park, UCL and Imperial College.
Year(s) Of Engagement Activity 2023
 
Description Breeders Day 2024 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A demonstration day focused aimed at Plant Breeders and related agri-businesses to demonstrate JIC research
Year(s) Of Engagement Activity 2024
 
Description Conference poster and short talk at UK Clock Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Post-doc Jack Dorling from the Dodd group at JIC gave a poster and short oral presentation at the UK Clock Club conference in September 2023. The poster/presentation was entitled, "A novel circadian phenotype in Bacillus subtilis colony expansion." Dr Dorling won both the first prize for the poster, and first prize for the oral presentation.
Year(s) Of Engagement Activity 2023
 
Description Conference poster and short talk at UK Clock Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact PhD student Deirdre Lynch from the Dodd group at JIC gave a poster and short oral presentation at the UK Clock Club conference in September 2023. The poster/talk was entitled, "The effect of seed set temperature upon circadian clock-associated phenotypes," and won runner-up poster prize.
Year(s) Of Engagement Activity 2023
 
Description Conference poster at UK Clock Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Graduate student Richard Dekeya from the Dodd group at JIC gave a poster presentation at the UK Clock Club conference in September 2023. The poster was entitled, "Circadian regulation of rhizosphere interactions."
Year(s) Of Engagement Activity 2023
 
Description Discussions with Industry 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Discussion on the potential of gene edited crops with industry
Year(s) Of Engagement Activity 2023
 
Description Economist 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Economist article on Genome Editing
Year(s) Of Engagement Activity 2025
URL https://www.economist.com/technology-quarterly/2025/02/21/eat-your-ge-greens
 
Description Editorial Career Panel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The JIC Post-Doc Voice Committee coordinated a discussion about potential careers in journal editorial work, to showcase this as a potential career to JIC post-docs and PhD students. Antony Dodd participated in the discussion panel in his capacity as an editor at the plant sciences journal New Phytologist.
Year(s) Of Engagement Activity 2023
 
Description Find My Futures 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact An event organised by JIC and UEA to raise awareness of science as a career to secondary school children.
Participated in meet a STEM professional which raises awareness of the range of jobs on offer in science.
Year(s) Of Engagement Activity 2024
 
Description Formation of and contribution to ongoing BioClocksUK Network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Antony Dodd is part of the group of volunteers that have formed the BioClocks UK network. The aim of the network is to support the circadian clock community inc reading bridges between chronobiological research and real-world impact. It aims to consolidate, engage and expand circadian biology research to establish and nurture robust cycles of discovery and impact. The team will also coordinate and lead training for the next generation of chronobiologists. BioClocks UK was started by volunteers from universities, the BBSRC-supported institutes JIC and IBERS, and the MRC Laboratory of Molecular Biology. BioClocks UK was recently awarded a 5-year BBSRC responsive mode grant to support its activities, held at the University of Leicester with grant PI Bambos Kyriacou.

Antony Dodd leads and edits the newsletter for BioClocks UK.
Year(s) Of Engagement Activity 2022,2023,2024
 
Description Frontier Agriculture visit to JIC 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Frontier brought a group of 15 junior agronomists to hear about the latest science and build relationships with JIC.
This led to delivering a presentation at the Eastern Area Conference in 2024 on our science relevant to farming and agronomy and genome editing.
Year(s) Of Engagement Activity 2024
 
Description Interview and article for Axios News, USA 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Antony Dodd was interviewed by Axios News (an online publisher similar to The Atlantic) about his research on circadian rhythms in plants, with a focus on a recent publication in Nature Plants about the clock and low temperature responses. The article was entitled, "Cold can't stop crops."
Year(s) Of Engagement Activity 2023
 
Description Interview for local TV news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview about discovery of new wheat dwarfing genes on BBC Look East TV news.
Year(s) Of Engagement Activity 2022
 
Description Interview with BBC Farming Today (Radio 4) about a specific publication from the laboratory 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Dodd lab published a study in Nature Plants concerning a cell signalling pathway in plants that integrates low temperature and circadian signals. This was of interest to the BBC Farming Today radio program, because of the discovery's potential implications for the responses of crops to fluctuating temperatures. A reporter from Farming Today visited JIC to interview Antony Dodd and visit the research facilities.
Year(s) Of Engagement Activity 2023
 
Description Interview with BBC world service 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Antony Dodd contributed to a discussion within the Unexpected Elements programme on the BBC World Service. The discussion was a Q&A about whether plants sleep, based on Dodd's expertise in the field of chronobiology.
Year(s) Of Engagement Activity 2023
 
Description Invited oral presentation at Royal Society UK/Brazil bilateral conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Antony Dodd was invited to the Royal Society UK-Brazil bilateral conference, held at The Royal Society in London during October 2023. The conference had a focus topic on agriculture. Antony Dodd gave an oral presentation entitled, "Circadian clocks adapt crops to a rotating planet."
Year(s) Of Engagement Activity 2023
 
Description Invited oral presentation at a Royal Society Theo Murphy conference on circadian regulation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact In September 2023, a Royal Society Theo Murphy conference "Time to take time seriously: circadian rhythms in infection and immunity" occurred in Newcastle, UK. Antony Dodd was invited to this meeting and gave a presentation entitled, "Harnessing circadian rhythms for a healthy planet."
Year(s) Of Engagement Activity 2023
 
Description Invited oral presentation at a mini-symposium at the University of Helsinki 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Antony Dodd gave an invited oral presentation at a mini-symposium held at the University of Helsinki, during December 2023, focused on light signalling in plants. This formed part of the training program for the PhD students in Helsinki, and also provided excellent opportunities to develop a new network with invited scientists from across Europe.
Year(s) Of Engagement Activity 2023
 
Description Invited oral presentation at the Annual Symposium of the UCSD Center for Circadian Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited oral presentation at the Annual Symposium of the Center for Circadian Biology of the University of California, San Diego. The talk was entitled, "Circadian gating for signal integration."
Year(s) Of Engagement Activity 2023
 
Description Invited oral presentation at the kick-off symposium of a new collaborative project 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A kick-off symposium was held for a new project funded by the Japanese Society for the Promotion of Science grant "Key-Molecule-Network in Plant Reproduction" Symposium held at the University of Tokyo, Japan. Antony Dodd gave a presentation at this symposium entitled, "Integration of circadian and environmental cues"
Year(s) Of Engagement Activity 2023
 
Description Invited talk - IPK, Gatersleben 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Chris Morgan delivered an invited Genetics seminar at the IPK research institute in Gatersleben, Germany in November 2024. The talk sparked discussion and the subsequent sharing of knowledge and research ideas/resources.
Year(s) Of Engagement Activity 2024
 
Description Invited talk - University of Warwick 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Antony Dodd gave an invited talk at the University of Warwick medical school, on the topic of the circadian clock in the soil bacterium Bacillus subtilis. Following the discussions that occurred during the visit, it was decided that there were some interesting areas of scientific overlap that have led to plans to write a collaborative sLoLa grant.
Year(s) Of Engagement Activity 2024
 
Description Invited talk at Kyoto University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Antony Dodd was invited to give a research seminar to the Center for Ecological Research of Kyoto University. The topic of the presentation was the circadian clock in the soil bacterium Bacillus subtilis
Year(s) Of Engagement Activity 2024
 
Description Leadership of the circadian clock session at the International Conference on Arabidopsis Research, 2023 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Antony Dodd organized and led the session on circadian rhythms at the International Conference on Arabidopsis Research, 2023, held in Chiba, Japan. Tokitaka Oyama from Kyoto University co-organized the session with Dodd. The session was entitled, "Understanding circadian regulation in unpredictable environments."
Year(s) Of Engagement Activity 2023
 
Description Meeting with all-party parliamentary group on Nutrition for Development 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact JIC hosted a visit of the APPG on Nutrition for Development. Antony Dodd met with the group to summarise and discuss a project that has developed and commercialised pea shoots that are fortified with Vitamin B12.
Year(s) Of Engagement Activity 2025
 
Description Met with DAniel Zeichner MP 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Discussions on the Germplasm resource unit and the transformation platform. Introducing genome editing.
Year(s) Of Engagement Activity 2023
 
Description Morley Innovation Day 2024 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Discussing ongoing research and research findings with farmers and local agri-businesses at the 2024 Morley Innovation Day
Year(s) Of Engagement Activity 2024
 
Description New Plant Breeding Technologies opportunities and challenges with RAGT global wheat breeders 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact New Plant Breeding Technologies opportunities and challenges with RAGT global wheat breeders
Year(s) Of Engagement Activity 2024
 
Description Oral presentation at the International Conference on Arabidopsis Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Antony Dodd gave an oral presentation at the International Conference on Arabidopsis Research, held in Chiba (Japan) during June 2024. The talk was entitled, "Integration of circadian and environmental cues."
Year(s) Of Engagement Activity 2023
 
Description Presentation and Discussion with Oxford Centre for Islamic Studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation and Discussion with Oxford Centre for Islamic Studies
Year(s) Of Engagement Activity 2024
 
Description Presentation at JIC Breeders Day on Genome editing 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presentation on genome editing to plant breeders, growers, agri-industries to raise awareness and understand challenges.
Year(s) Of Engagement Activity 2023
 
Description Press Release ERC grant to investigate biological clocks 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 47 stories in national and international media
82m people reached online
Year(s) Of Engagement Activity 2024
URL https://www.jic.ac.uk/press-release/dreams-come-true-for-researchers-as-they-win-major-european-fund...
 
Description Press Release: Breakthrough AI model can translate the language of plant life 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A press release on new AI model which was distributed through 45 national and international stories including The Independent, Yahoo Canada, The Times of India
reaching 1.8bln people online.
Year(s) Of Engagement Activity 2025
URL https://www.jic.ac.uk/news/breakthrough-ai-model-can-translate-the-language-of-plant-life/
 
Description Radio 4 Farming Today 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Interview with Radio4 Farming Today about novel wheat dwarfing gene that could improve growth in dry climates.
Year(s) Of Engagement Activity 2022
 
Description Royal Society Brian Cox School Experiments YouTube Videos 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact I participated in filming an educational video as part of the Royal Society School experiments videos. The film's topic was Gene Editing for Improved Crop Nutrition. The video was presented by Brian Cox. The video is aimed for educational purposes for school children aged 11-14 and can be used by teachers.
Year(s) Of Engagement Activity 2023,2024
URL https://youtu.be/wfghDz2jm9A?si=X9Z6qhQOaeTE8vHP
 
Description SciDev podcast - Scientists harness gene editing for climate-resilient wheat 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Podcast on using genome editing for climate-resilient wheat
Year(s) Of Engagement Activity 2024,2025
URL https://www.scidev.net/global/podcast/scientists-harness-gene-editing-for-climate-resilient-wheat/
 
Description Talk to the Norfolk branch of the Institute for Agricultural Management 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Antony Dodd was invited to give an evening talk to the Norfolk branch of the Institute for Agricultural Management, held at a local agricultural college (Easton College). The talk was entitled "How and why do living organisms tell the time." The meeting was attended primarily by local agricultural practitioners, including farmers and farm managers.
Year(s) Of Engagement Activity 2023
 
Description Talking Biotech Podcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was interviewed for a podcoast about a new dwarfing gene we discovered in wheat that could enhance yields in dry climates.
Year(s) Of Engagement Activity 2022
URL https://www.colabra.app/podcasts/talking-biotech/373-genes-controlling-plant-size/
 
Description Through the Microscope workshop with Edible East and Gressinghall Farm 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Exploring ways to present our research, relevant to agriculture through artistic media
Year(s) Of Engagement Activity 2024
 
Description Uncovering the secrets of wheat: are three genes better than one? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Presented to Gatsby undergraduate summer school about research in polyploid crops and its importance for sustainable agriculture.
Year(s) Of Engagement Activity 2024
URL https://www.youtube.com/watch?v=sZ65oUjRkwY
 
Description Visit to Centre of the Cell, London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact To discuss approaches to engagement and inform our outreach and engagement work
Year(s) Of Engagement Activity 2024
 
Description Visit to KWS UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Gain insights into the KWS Plant Breeding Company
Year(s) Of Engagement Activity 2024