Food Microbiome and Health: Elucidating how foods influence host responses
Lead Research Organisation:
QUADRAM INSTITUTE BIOSCIENCE
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
To gain mechanistic insights into how plant-based foods and food-induced changes in the GIT microbiome affect host responses within and beyond the GIT
Planned Impact
unavailable
Publications
Beraza N
(2023)
Ketohexokinase-C: The mechanistic link between dietary sugars and protein acetylation during liver steatosis.
in Journal of hepatology
Bernuzzi F
(2023)
Sulforaphane rewires central metabolism to support antioxidant response and achieve glucose homeostasis.
in Redox biology
Eguchi T
(2024)
The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response.
in The Journal of cell biology
Gao Y
(2024)
In vitro batch fermentation demonstrates variations in the regulation of gut microbiota and metabolic functions by ß-glucans of differing structures
in Food Research International
Gul L
(2025)
Protocol for predicting host-microbe interactions and their downstream effect on host cells using MicrobioLink
in STAR Protocols
Juge N
(2023)
Encyclopedia of Cell Biology
Laplanche V
(2025)
The human gut symbiont Ruminococcus gnavus displays strain-specific exopolysaccharides modulating the host immune response.
in Carbohydrate polymers
| Description | DTP |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2028 |
| Description | DTP PhD Studentship |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2028 |
| Description | Delivering Sustainable Wheat: Nutritional Traits (John Innes Centre) |
| Amount | £707,944 (GBP) |
| Funding ID | BBS/E/JI/230003C |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2028 |
| Description | EDESIA DTP |
| Amount | £200,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 09/2024 |
| Description | MMB DTP |
| Amount | £80,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2027 |
| Description | Microbiome of HR+ Breast Cancer Patients |
| Amount | £300,000 (GBP) |
| Funding ID | 2023.11PR1673 |
| Organisation | Breast Cancer Now |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2024 |
| End | 06/2027 |
| Description | NRPDTP |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2028 |
| Description | NRPDTP CASE |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2028 |
| Description | NRPDTP VitB12 |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 06/2024 |
| Description | The Norwich Research Park Biosciences Doctoral Training Partnership |
| Amount | £18,000,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2027 |
| Description | UEA MRC -IAA |
| Amount | £60,000 (GBP) |
| Organisation | University of East Anglia |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2024 |
| End | 01/2026 |
| Description | international partnering award Spain |
| Amount | £10,000 (GBP) |
| Organisation | Quadram Institute Bioscience |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2024 |
| End | 06/2024 |
| Title | transgenic animals |
| Description | With this funding we have been able to complete our generation of single and double endothelial cell specific knockouts of alpha5 integrin beta3 integrin and neuropilin-1 |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | We will share these tools if asked |
| Description | Christiana Rurhberg |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have contributed our knowledge of mass spec analyses |
| Collaborator Contribution | They have contributed their knowledge of retinal angiogenesis assays |
| Impact | No direct outputs yet, but expect joint publications, and possibly joint grant applications. |
| Start Year | 2015 |
| Description | Collaboration with Dr Melanie Rutkowski, UVa |
| Organisation | University of Virginia (UVa) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We have been collaborating on multiple projects that have led to multiple publications. |
| Collaborator Contribution | Exchange of experimental data sets. |
| Impact | Multiple publications |
| Start Year | 2020 |
| Description | Collaboration with Professor Simon Milling |
| Organisation | University of Glasgow |
| Department | School of Life Sciences Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide access to cancer models and microbiota analyses. |
| Collaborator Contribution | Professor Milling assist us with our understanding and analyses of mucosal immunology. |
| Impact | Grant proposals Publications (pre-prints) |
| Start Year | 2017 |
| Description | Single cell sequencing technology with EI |
| Organisation | Earlham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Intellectual input (conceptualised the research project), trained staff , study supervision and obtained funding. |
| Collaborator Contribution | Provide expertise on single cell sequencing technology, trained staff, provided resources, supervision of this experimental part |
| Impact | no outputs yet. |
| Start Year | 2022 |
| Title | Exopolysaccharide Compositions and use thereof |
| Description | Use of EPS from bifidobacteria to treat cancer |
| IP Reference | |
| Protection | Patent / Patent application |
| Year Protection Granted | 2024 |
| Licensed | No |
| Description | Industry-academy workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | 45 participants including 15 SMEs on Food and Microbes - "Sustainable food production: from soil health, nutrition to human health" |
| Year(s) Of Engagement Activity | 2025 |
| Description | Norwich Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Activity focused on liver regeneration and impact of unhelathy diets in liver health at the Norwich Science Festival. Reached over 300 children and carers. |
| Year(s) Of Engagement Activity | 2024 |