Theory and practice in the mapping of quantitative trait loci
Lead Research Organisation:
Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The basic tools to scan of livestock genomes to map quantitative trait loci (QTLs) are now in place and in use. Full exploitation of the tools in research and in commercial application requires developments in a number of areas. This project provides core support onto which will be built projects which will tackle three key areas: 1) Developing the analytical methods to allow high resolutions QTL mapping through exploitation of linkage disequilibrium in outbred populations. 2) Putting the developed methods into a user- friendly shell, allowing effective exploitation by both researchers and industry. 3) Applying the developed methodologies to both further our own experimental programme and to refine the approaches and demonstrate their efficiency in action. This work is essential underpinning for the research programmes of the Institute and the BBSRC.
Planned Impact
unavailable
People |
ORCID iD |
| Christopher Haley (Principal Investigator) |
Publications
Nagamine Y
(2009)
Detection of multiple quantitative trait loci and their pleiotropic effects in outbred pig populations.
in Genetics, selection, evolution : GSE
Navarro P
(2006)
Genetic parameters for blood oxygen saturation, body weight and breast conformation in 4 meat-type chicken lines.
in British poultry science
Powell JE
(2012)
Optimal use of regression models in genome-wide association studies.
in Animal genetics
Rowe SJ
(2009)
Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology.
in Genetics, selection, evolution : GSE
Rowe SJ
(2008)
Detecting dominant QTL with variance component analysis in simulated pedigrees.
in Genetics research
Sauvage C
(2010)
QTL for resistance to summer mortality and OsHV-1 load in the Pacific oyster (Crassostrea gigas).
in Animal genetics
Tuiskula-Haavisto M
(2011)
Quantitative trait loci affecting eggshell traits in an F(2) population.
in Animal genetics
Volckaert FA
(2012)
Heritability of cortisol response to confinement stress in European sea bass dicentrarchus labrax.
in Genetics, selection, evolution : GSE
Wei WH
(2011)
High throughput analyses of epistasis for swine body dimensions and organ weights.
in Animal genetics
| Description | We identified genes involved in terrestrial and aquatic livestock performance that contribute to improved sustainability of production in these sectors. |
| Exploitation Route | Improved sustainability of livestock production and impact to improve animal welfare. |
| Sectors | Agriculture Food and Drink |
| Description | Tools and Resources Development Fund |
| Amount | £107,308 (GBP) |
| Funding ID | BB/H024484/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2010 |
| End | 05/2012 |
| Description | Agricygen |
| Organisation | Agricultural Research Institute |
| Country | Cyprus |
| Sector | Public |
| PI Contribution | Use of genomics to optimise sheep and cattle breeding in order to maximise milk production for halloumi cheese |
| Collaborator Contribution | Local livestock expertise and husbandry and nutrition expertise for the optimisation of milk production in Cyprus |
| Impact | Project is in its early stages. No outputs as yet. |
| Start Year | 2017 |
| Description | LNS - IPN |
| Organisation | Landcatch Natural Selection Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Design if studies, joint grant application, advice on data analysis |
| Collaborator Contribution | Joint publication |
| Impact | Publications listed separately |
| Start Year | 2006 |
| Description | WAU - CNV |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Input to design of study and analysis of results |
| Collaborator Contribution | Joint publication |
| Impact | Joint publication listed separately |
| Start Year | 2007 |
| Description | Edinburgh Alliance for Complex Trait Genetics |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-organise a twice-yearly meeting to coordinate complex trait genetic research focussed on Edinburgh but with national participation. |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017,2018,2019,2020 |
| URL | https://www.wiki.ed.ac.uk/display/eactg/Edinburgh+Alliance+for+Complex+Trait+Genetics |