Dynamics of mean gain and variance analysis
Lead Research Organisation:
University of Edinburgh
Department Name: UNLISTED
Abstract
The proposed research in quantitative genetics is concerned with genetic change (?G) and associated risks, such as introducing genetic diseases, related to the rate of inbreeding (?F). The approach taken will be to exploit the concept of a long-term genetic contribution of an ancestor that has been largely developed in our laboratory. It has provided a unifying concept and provided solutions to many long-standing genetic problems. The issues addressed will be: near-random mating where the benefits of mating will be combined into two weighted components corresponding to prospective and retrospective actions; improved operational tools (including markers) that exploit the results from the near random mating; linked gene flow to underpin improved linkage disequilibrium methods; and improved predictions for non-random mating and exponential contribution models.
Organisations
People |
ORCID iD |
| John Woolliams (Principal Investigator) |
Publications
Woolliams J
(2010)
The value of cloning in MOET nucleus breeding schemes for dairy cattle
in Animal Production
Woolliams J
(2010)
The value of indicator traits in the genetic improvement of dairy cattle
in Animal Production
Woolliams J
(2010)
Embryo manipulation in cattle breeding and production
in Animal Production
Woolliams C
(2010)
Studies on lambs from lines genetically selected for low and high copper status 1. Differences in mortality
in Animal Science
Woolliams J
(2010)
Genetic contributions of Finnish Ayrshire bulls over four generations
in Animal Science
Lewis T
(2007)
Genotype by mating type interaction for litter size in Landrace and Large White sows
in Animal Science
Wiener G
(2010)
Consequences of inbreeding for financial returns from sheep
in Animal Science
Villanueva B
(2010)
Genetic progress and inbreeding for alternative nucleus breeding schemes for beef cattle
in Animal Science
Sinnett-Smith P
(2010)
Effects of recombinant DNA-derived bovine somatotropin on growth, carcass characteristics and meat quality in lambs from three breeds
in Animal Science
Wiener G
(2010)
Effects of rapid inbreeding and of crossing inbred lines on the growth of linear body dimensions of sheep
in Animal Science
Woolliams J
(2010)
Endogenous pulsing and stimulated release of growth hormone in dairy calves of high and low genetic merit
in Animal Science
Woolliams J
(2010)
The effect of dietary protein on metabolite concentrations during fasting in calves differing genetically in dairy merit
in Animal Science
Sinnett-Smith P
(2010)
Adipose tissue metabolism and cell size: variation between subcutaneous sites and the effect of copper supplementation
in Animal Science
Woolliams J
(2010)
Retention of copper in the liver of sheep genetically selected for high and low concentrations of copper in plasma
in Animal Science
Wiener G
(2010)
Effects of rapid inbreeding and of crossing of inbred lines on conception rate, prolificacy and ewe survival in sheep
in Animal Science
Luo Z
(2010)
Controlling inbreeding in dairy MOET nucleus schemes
in Animal Science
Sinnett-Smith P
(2010)
Biochemical and physiological responses to metabolic stimuli in Friesian calves of differing genetic merit for milk production
in Animal Science
Woolliams J
(2010)
The effect of breed of sire on the accumulation of copper in lambs, with particular reference to copper toxicity
in Animal Science
Woolliams J
(2010)
Modifications to MOET nucleus breeding schemes to improve rates of genetic progress and decrease rates of inbreeding in dairy cattle
in Animal Science
Woolliams J
(2010)
Decision rules and variance of response in breeding schemes
in Animal Science
Woolliams J
(2010)
A note on the growth and food consumption of crossbred lambs of five sire breeds
in Animal Science
Woolliams J
(2010)
Studies on lambs from lines genetically selected for low and high copper status 2. Incidence of hypocuprosis on improved hill pasture
in Animal Science
Field A
(2010)
The effect of breed of sire on the urinary excretion of phosphorus and magnesium in lambs
in Animal Science
Sinnett-Smith P
(2010)
Genetic variations in subcutaneous adipose tissue metabolism in sheep
in Animal Science
Woolliams J
(2010)
The effects of breed, crossbreeding and other factors on variation in fleece and skin traits
in Animal Science
Meuwissen T
(2010)
Responses of multi-trait selection in open nucleus schemes for dairy cattle breeding
in Animal Science
Wiener G
(2010)
Effects of rapid inbreeding and of crossing of inbred lines on the body weight growth of sheep
in Animal Science
Bishop S
(2010)
Utilization of the sex-determining region Y gene in beef cattle breeding schemes
in Animal Science
Wiener G
(2010)
Genetic selection to produce lines of sheep differing in plasma copper concentrations
in Animal Science
Wiener G
(2010)
Effects of breed, rapid inbreeding, crossbreeding and environmental factors on fleece weight and fleece shedding in sheep
in Animal Science
Woolliams J
(2010)
The effect of breed type and inbreeding on characteristics of the fleece and skin of 12-week-old lambs
in Animal Science
Lipschutz-Powell D
(2012)
Bias, accuracy, and impact of indirect genetic effects in infectious diseases.
in Frontiers in genetics
Sánchez-Molano E
(2015)
Genomic prediction of traits related to canine hip dysplasia.
in Frontiers in genetics
Woolliams J
(2009)
Prediction of long-term contributions and inbreeding in populations undergoing mass selection
in Genetical Research
Tsairidou S
(2016)
Quantitative genetic analysis of the bTB diagnostic single intradermal comparative cervical test (SICCT).
in Genetics, selection, evolution : GSE
Pong-Wong R
(2007)
Optimisation of contribution of candidate parents to maximise genetic gain and restricting inbreeding using semidefinite programming.
in Genetics, selection, evolution : GSE
Iheshiulor OO
(2016)
Within- and across-breed genomic prediction using whole-genome sequence and single nucleotide polymorphism panels.
in Genetics, selection, evolution : GSE
Daetwyler HD
(2007)
Inbreeding in genome-wide selection.
in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
Jenko J
(2017)
Cow genotyping strategies for genomic selection in a small dairy cattle population.
in Journal of dairy science
Banos G
(2017)
Genetic evaluation for bovine tuberculosis resistance in dairy cattle.
in Journal of dairy science
Cooper TA
(2016)
Genomic evaluation, breed identification, and population structure of Guernsey cattle in North America, Great Britain, and the Isle of Guernsey.
in Journal of dairy science
Eaglen SA
(2011)
Phenotypic effects of calving ease on the subsequent fertility and milk production of dam and calf in UK Holstein-Friesian heifers.
in Journal of dairy science
Woolliams J
(2010)
Get off my land
in New Scientist
Canela-Xandri O
(2016)
Improved Genetic Profiling of Anthropometric Traits Using a Big Data Approach.
in PloS one
Bovine HapMap Consortium
(2009)
Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds.
in Science (New York, N.Y.)
Woolliams J
(2009)
Analysis of factors affecting superovulatory responses in ruminants
in The Journal of Agricultural Science
| Description | The work done on this grant has led to the development of the upper bound for achievable genetic gain for a given rate of inbreeding. This represents the highest efficiency for converting genetic variance into changes in the mean of the trait, for example during selection. It is generic for all diploid species which includes all livestock. At this optimum the most efficient selection schemes will have maximal avoidance of relatives during mating. |
| Exploitation Route | They will be increasingly implemented by breeding programmes. |
| Sectors | Agriculture, Food and Drink |
| Description | Management of diversity in commercial breeding schemes. development of evaluation models for novel commercial traits. |
| First Year Of Impact | 2011 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal |
| Description | Chair of FAO Working Group on "Secondary Guidelines on Management of Small Populations at Risk" |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Preparation for UN Global Plan of Action for Animal Genetic Resources and Interlaken Declaration in 2007 |
| URL | http://www.fao.org/docrep/010/a1404e/a1404e00.htm |
| Description | Membership of Defra National Consultative Committee on Farm Animal Genetic Resources, 2001 to 2002 |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | UK Country Report on Farm Animal Genetic Resources 2002. This was the first time this policy area was addressed and formed an international report to FAO. |
| URL | https://www.gov.uk/government/publications/uk-country-report-on-farm-animal-genetic-resources-2002 |
| Description | Membership of EAAP Working Group on Animal Genetic Resources |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Informing EU policy on regulations and incentives for managing farm animal genetic resources. |
| Description | Membership of FAO Drafting Group for 3rd Intergovernmental Technical Working Group, 2003 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Drafting resolutions for UN inter-governemental meeting on agricultural policies, ultimately leading to UN's Global Plan of Action for Farm Animal Genetic Resources and the Interlaken Agreement in 2007. |
| URL | http://www.fao.org/docrep/010/a1404e/a1404e00.htm |
| Description | Membership of FAO Working Group on Ex Situ Conservation of Livestock |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Preparation for UN Global Plan of Action for Animal Genetic Resources and the Interlaken Declaration in 2007. |
| URL | http://www.fao.org/docrep/010/a1404e/a1404e00.htm |
| Description | Membership of FAO Working Group on In Situ Conservation of Livestock |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Preparation for UN Global Plan of Action for Animal Genetic Resources and the Interlaken Declaration in 2007. |
| URL | http://www.fao.org/docrep/010/a1404e/a1404e00.htm |
| Description | Membership of FAO/ISZ Working Group on Implications of Developments in Biotechnology for the Conservation of Animal Genetic Resources at Risk: Reversible DNA Quiescence and Cloning. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Informed UN of scientific background to the existing cloning technology, separating fact from fiction. |
| Description | INIA |
| Organisation | National Institute for Agricultural and Food Research and Technology |
| Country | Spain |
| Sector | Public |
| PI Contribution | Training, design and interpretation of studies, writing papers for journals |
| Collaborator Contribution | Personnel, funding for personnel, scientific discussion, writing papers. |
| Impact | Scientific papers. New PhDs and trained post-docs in Spain. |
| Start Year | 2008 |
| Description | Norwegian University of Life Sciences (NMBU), Aas, Norway |
| Organisation | Norwegian University of Life Sciences (NMBU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Supervised and lectured to postgraduate students. Provided intellectual input into science proposals, ongoing projects and outputs, including research papers. |
| Collaborator Contribution | Facilities, students, intellectual stimulation, new project ideas, data, and other academic outputs such as scientific papers. |
| Impact | Joint scientific papers. Joint scientific projects (UoE/NMBU). |
| Description | University of Leon |
| Organisation | University of Leon |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Training, design and interpretation of studies. |
| Collaborator Contribution | Personel. Funding for personnel. |
| Impact | Training, papers, new PhDs. |
| Start Year | 2008 |
| Description | University of Osijek |
| Organisation | University of Osijek |
| PI Contribution | Training of post-graduate student for a PhD. provison of data. |
| Collaborator Contribution | Personnel and funding required. |
| Impact | Evaluation models for boar taint to be used in selection. Training in breeding for a Croatian PhD. |
| Start Year | 2010 |