Sino-British Centre for Research on Avian Diseases
Lead Research Organisation:
The Pirbright Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The major objective of this proposal is to establish a Joint Sino-British Centre for Research
on Avian Diseases led by Pirbright Institute and Shandong Binzhou Academy. It will also
function as a virtual research centre with a number of Investigators from the partnering
Institutes in both countries. The centre will provide infrastructure for basic research and
training for post-doctoral scientists and students from both countries.
The award objectives are summarised as follows:
1. Identify major avian disease challenges to develop joint research strategies to combat
losses in both countries
2. Develop a platform for sustainable long-term partnerships with major Chinese Academic
Institutions in avian disease research
3. Apply for joint research funding in both countries to strengthen the research base on
avian diseases.
4. Developing future researchers in avian diseases through training of students and postdoctoral
fellows.
5. Build plans for knowledge exchange and commercialisation from the joint research
efforts.
on Avian Diseases led by Pirbright Institute and Shandong Binzhou Academy. It will also
function as a virtual research centre with a number of Investigators from the partnering
Institutes in both countries. The centre will provide infrastructure for basic research and
training for post-doctoral scientists and students from both countries.
The award objectives are summarised as follows:
1. Identify major avian disease challenges to develop joint research strategies to combat
losses in both countries
2. Develop a platform for sustainable long-term partnerships with major Chinese Academic
Institutions in avian disease research
3. Apply for joint research funding in both countries to strengthen the research base on
avian diseases.
4. Developing future researchers in avian diseases through training of students and postdoctoral
fellows.
5. Build plans for knowledge exchange and commercialisation from the joint research
efforts.
Planned Impact
unavailable
People |
ORCID iD |
| Venugopal Nair (Principal Investigator) |
Publications
Cui Z
(2023)
Chicken Glycogen Synthase Kinase 3ß Suppresses Innate Immune Responses and Enhances Avian Leukosis Virus Replication in DF-1 Cells.
in Microbiology spectrum
Dai M
(2022)
Duck CD8+ T Cell Response to H5N1 Highly Pathogenic Avian Influenza Virus Infection In Vivo and In Vitro.
in Journal of immunology (Baltimore, Md. : 1950)
Gao Y
(2016)
Avian leukosis virus subgroup J induces VEGF expression via NF-?B/PI3K-dependent IL-6 production
in Oncotarget
He S
(2020)
Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction.
in Veterinary microbiology
Jadhav A
(2020)
Genomic Diversity and Evolution of Quasispecies in Newcastle Disease Virus Infections.
in Viruses
Li J
(2018)
Production, characterization, and epitope mapping of a monoclonal antibody against genotype VII Newcastle disease virus V protein.
in Journal of virological methods
Li K
(2020)
Prevention of Avian Retrovirus Infection in Chickens Using CRISPR-Cas9 Delivered by Marek's Disease Virus.
in Molecular therapy. Nucleic acids
| Description | we have developed a collaborative network of research centres in China and the United Kingdom to work on poultry diseases. Using this network, we have carried out joint research that resulted in joint publications and secured joint grant funding. We have developed innovative vaccines, some of which are being tested for efficacy to protect chickens from major viral diseases |
| Exploitation Route | Working together closely to find solutions, secure joint grant applications to carry out further research on major avian diseases. Covid-19 restrictions did affect the exchange visits of scientist between China and UK, and we are requesting to further extension beyond the end date of the project for the exchange visits and conduct the experiments |
| Sectors | Agriculture Food and Drink Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | http://www.uk-china-cerad.org/ |
| Description | The network has helped to work together to find solutions to the problems with avian diseases in the UK and China. UK-China Centre of Excellence for Research on Avian Diseases (CERAD) has significantly grown in terms of numbers of academic institutions joining CERAD (https://www.uk-china-cerad.org/). Various innovative research findings have been used for securing additional joint research funds as well as for translation into improved diagnostic and control strategies such as vaccines against avian diseases, introducing de novo genetic resistance to diseases. some of the novel recombinant vaccines against avian diseases are currently being evaluated for commercial use to protect against major avian diseases. The success of the project has been acknowledged when it was shortlisted for the Newton Prize 2019. |
| First Year Of Impact | 2019 |
| Sector | Agriculture, Food and Drink,Education,Healthcare,Manufacturing, including Industrial Biotechology |
| Impact Types | Societal Economic |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £440,000 (GBP) |
| Funding ID | BB/R007896/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | Innovations in control of avian infectious diseases for sustainable growth and food security in low and middle income countries |
| Amount | £355,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 11/2021 |
| Description | Recombinant MDV vaccine expressing gRNA targeting REV using CRISPR/Cas9 system to prevent MDV and REV infection |
| Amount | ¥120,000 (CNY) |
| Funding ID | SKLVBF201605 |
| Organisation | State Key Laboratory of Veterinary Biotechnology |
| Sector | Public |
| Country | China |
| Start | 01/2016 |
| End | 12/2017 |
| Description | UK-China partnership on Global Food Security: Combating avian tumor diseases for sustainable poultry proudction |
| Amount | £382,000 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Title | CRISPR/Cas9-based gene editing pipeline for generation of recombinant herpesvirus vaccines or targeted editing |
| Description | CRISPR/Cas9-based gene editing pipe line was established for rapid generation of recombinant herpesvirus vaccines, which involves the use of stable Cas-9 expressing cell lines or through transient Cas9 expression |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The major impact of this will be enabling advanced research in developing new innovative vaccines for successful and effective control of avian diseases for enhancing global food security |
| URL | https://www.jove.com/video/58193/generating-recombinant-avian-herpesvirus-vectors-with-crisprcas9-ge... |
| Description | Global Alliance for Research on Avian Diseases |
| Organisation | Global Alliance for Research on Avian Diseases |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | This alliance led by Pirbright has participation from over 40 countries and comprises of academics and industry professionals. This forum helps in working together, identifies the challenges and opportunities for improved control of avian diseases |
| Collaborator Contribution | Two successful international meetings were organised as part of this alliance, one in London in 2015 and most recent one in Hanoi, Vietnam in January 2018 |
| Impact | Organisation of two successful international meetings and development of significant collaborations |
| Start Year | 2015 |
| Description | Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Shanghai Veterinary Research Institute |
| Country | China |
| Sector | Public |
| PI Contribution | Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector |
| Collaborator Contribution | Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/). |
| Impact | organised joint meeting in China and the UK to discuss on challenges and opportunities |
| Start Year | 2017 |
| Title | A METHOD FOR PRODUCING AVIAN LEUKOSIS VIRUS(ALV)-RESISTANT AVIAN LINE USING CRISPR/CAS9 SYSTEM |
| Description | Patent describes a method for generating avian leukosis virus-resistant chicken line using CRISPR/Cas9-based gene editing approaches |
| IP Reference | 10-2018-0011871 Korea |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | Commercial In Confidence |
| Impact | The technology allows introduction of de novo genetic resistance against avian leukosis viruses using gene editing technologies |
| Description | AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro... |
| Description | Inauguration of the UK-China Centre of Excellence for Research on Avian Diseases (CERAD) and Symposium on Recent Advances in Avian Disease Research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Inauguration of the UK-China Centre of Excellence for Research on Avian Diseases (CERAD) and Symposium on Recent Advances in Avian Disease Research. This was held in Binzhou, Shandong province in China in 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | Interview for CGTN on the importance of poultry disease control in China and the significance of collaboration |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | It was an interview by the editor for CGTN on the contribution of Pirbright and the Chinese collaborations on controlling poultry diseases and improving avian health |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://newseu.cgtn.com/news/2020-01-28/British-and-Chinese-scientists-join-forces-to-fight-avian-di... |
| Description | Invitation to give keynote talk on 'Control of avian diseases: Challenges and opportunities' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave the Keynote talk on 'Control of avian diseases: Challenges and opportunities' at this International Symposium organized with an aim to gather international virology experts from both human and veterinary fields to share research experience, update findings and contribute their expertise through presentation and interactive discussion. The topics will cover a wide range of virology research common in both human and animal aspects. In addition, technological platforms such as vaccine development, and novel assays will be emphasized and addressed. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.biotec.or.th/virus-symposium2018/index.php |
| Description | Invited talk on 20th World Vaccine Congress Washington on 28th September 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk on 'Novel vaccine technique to target multiple poultry diseases using CRISPR/Cas9 system' at the 20th World Vaccine Congress in Washington |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.terrapinn.com/conference/world-vaccine-congress-washington/index.stm |
| Description | Invited talk on 28th September 2020 on ''Challenges and opportunities for control of infectious animal diseases including zoonosis' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | International Webinar of 'Epistemological approaches to animal disease control programmes with special reference to rabies' |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keynote talk at the World Veterinary Poultry Association meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give the keynote talk on 'Avian tumour viruses: their contribution to our understanding of cancer' at the World Veterinary Poultry Association XXth Congress in Edinburgh |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.wvpac2017.com/ |
| Description | Organised the 3rd UK-China CERAD meeting in Guildford, UK in July 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The 3rd UK-China CERAD meeting helped to bring together professional from both countries to identify challenges and exploit the opportunities for improved control of poultry diseases and increasing food security. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uk-china-cerad.org/ |
| Description | Organising and giving Keynote talk at the GARAD meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Global Alliance of Poultry industry professional and academia to discuss about the advances in control strategies of diseases |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://Garad.org |
| Description | Poultry Health course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry Health Course is run as a residential and online course to transfer recent advances in avian disease research from the laboratory to the field. |
| Year(s) Of Engagement Activity | Pre-2006 |
| URL | http://www.poultryhealthcourse.com/ |
| Description | Second Symposium of the UK-China Centre of Excellence for Research on Avian Diseases held in March 2016 in Binzhou, Shandong Province, China |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The second international meeting of the UK-China CERAD was attended by a number of delegates from both UK and China and reviewed the progress. Plans were drawn of further activities and plans for securing additional grants. |
| Year(s) Of Engagement Activity | 2016 |
| Description | V Nair invited to talk on 'Cell type- and disease stage-specific interactions of Marek's disease virus & the host' at the International Symposium on Marek's disease and avain herpesiviruses at Yangzhou, China during 29th July to 2nd Aug 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Most recent updates in the field of avian herpesvirus research was discussed and active engagements for future collaborations discussed |
| Year(s) Of Engagement Activity | 2018 |