ORT-VAC: live bacterial vectors for vaccine delivery

Lead Research Organisation: University of Cambridge
Department Name: Chemical Engineering and Biotechnology


We aim to revolutionise vaccination by developing an innovative oral vaccine delivery technology. Traditional vaccines require extensive and costly production, purification, formulation and storage, with needles used for administration. We will engineer live enteric ORT-VAC bacteria to carry plasmids expressing antigens. These uniquely enable stable, high-copy number plasmid maintenance without antibiotic resistance or other selectable marker genes, making them particularly suited for delivering DNA vaccines against influenza and HIV, which will also be developed by the consortium. Encapsulation technology will be optimised to enable the bacteria to be stored at ambient temperature, ingested and released into the small intestine, where they will stimulate a protective immune response. ORT-VAC therefore represents a cost-effective platform technology with built-in stability, adjuvanticity and efficacy.
Description We have found a way to stabilise live bacterial vaccines so that they can be better used in regions of the world where a cold supply chain is absent.
Exploitation Route The work has been extended to live probiotic bacteria
Sectors Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology

Description A patent was filed and the collaborating company is commercialising the findings
First Year Of Impact 2011
Sector Pharmaceuticals and Medical Biotechnology
Impact Types Economic