Adventurous Research in Chemistry at the University of Manchester

Lead Research Organisation: University of Manchester
Department Name: Chemistry

Abstract

This proposal outlines some adventurous chemistry projects that will be carried out at the University of Manchester. These projects all have the potential to change our understanding of a whole area of chemistry . Their scope covers the whole of the chemical sciences, from chemical biology to the development of new materials. At the biological interface, we propose to use biological molecules like DNA and RNA as scaffolds and moulds that will enable us to build complicated molecules from simple building blocks. Other projects require a physical understanding at the molecular level: for instance in the controlled assembly of particles at interfaces or the preparation of catalysts that rely on electron transfer processes to enable us to make other molecules efficiently and cleanly. At the other end of the spectrum, we wish to make molecules that are themselves of use as new materials, either as new liquid crystal phases or as polymers whose structures can be changed with temperature- effectively making moulds that can easily be removed. The idea of using shape and structure to control processes runs through all these proposals, and represents the future of chemistry.

Publications

10 25 50
publication icon
Bell NM (2010) A non-enzymatic, DNA template-directed morpholino primer extension approach. in Chemistry (Weinheim an der Bergstrasse, Germany)

publication icon
Aguilar JA (2010) Pure shift 1H NMR: a resolution of the resolution problem? in Angewandte Chemie (International ed. in English)

publication icon
N/a Meloni (2008) Energy and Charge Transfer in Sm complexes in Dalton TRansactions

 
Title Non-enzymatic transcription of nucleic acidsfor multi-parallel high throughput screening by SNPs and sequencing by synthesis 
Description Non-enzymatic transcription of nucleic acidsfor multi-parallel high throughput screening by SNPs and sequencing by synthesis 
IP Reference  
Protection Patent granted
Year Protection Granted
Licensed No
Impact Further development of synthetic and chemical biology approaches