Combined use of organo- and enzymic catalysis in three component couplings: Building blocks for bioactive molecule synthesis

Lead Research Organisation: University of Leeds
Department Name: Sch of Chemistry

Abstract

The preparation of biological molecules, such as drugs and agrochemicals, generally involves many separate synthetic steps. At the end of each step, an intermediate is usually purified before functionalisation in the next step. To improve the efficiency of the construction of such molecules, the number of separate reactions and purifications would need to be reduced. This proposal will generate new methods which will allow more than one step to be performed in a single reaction vessel. This approach is broadly analogous to would involve the concatenation of several steps Nature: metabolic pathways involve the processing of reaction intermediate by compatible (enzyme) catalysts in a single reaction vessel (the cell). The products of the new methodology will be exploited in the synthesis of building blocks for preparation of biologically active molecules.

Publications

10 25 50
 
Description IMI CHEM21 consortium
Amount € 1,200,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2012 
End 09/2016
 
Description AZ enzyme 
Organisation AstraZeneca
Department Research and Development AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Development of enzymes for synthesis
Collaborator Contribution Supervison. Input to project
Impact A paper.
Start Year 2009
 
Description GSK enzymes 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Development of chemically-modified enzymes
Collaborator Contribution Supervision. Input to project
Impact None to date
Start Year 2013