New Catalytic Reactions for Organic Synthesis
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
This proposal seeks to develop a new and more efficient way to prepare complex organic molecules. Our efforts will focus on the production of new catalysts for organic reactions, especially oxidation reactions. The development of new catalytic reactions is important to chemical industry as well as academia because it enables valuable organic compounds to be prepared quickly and efficiently with minimisation of cost and waste produced.The reactions that we seek to improve currently rely on the use of a large excess of chlorinating agent and, by using our new reagents, we are able to completely remove this requirement. This is clearly a big improvement on exisiting technology (ie a new and 'greener' way of making compounds), and will have significant ramifications for the use of new oxidising reactions, especially on a large scale.
People |
ORCID iD |
| Timothy Donohoe (Principal Investigator) |
Publications
Donohoe TJ
(2010)
New modes for the osmium-catalyzed oxidative cyclization.
in Organic letters
Donohoe T
(2009)
Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines
in Tetrahedron
Donohoe TJ
(2009)
Tethered aminohydroxylation (TA) reaction of amides.
in Organic letters
| Description | New efficient routes to complex molecules using new oxidation catalysts |
| Exploitation Route | Synthesis of molecules of interest and use especially in pharma. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | In the efficient synthesis of complex molecules with bioactivity |
| First Year Of Impact | 2010 |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |