Intercollegiate Platform on Powder-Based Synthesis and Modelling
Lead Research Organisation:
University College London
Department Name: Mechanical Engineering
Abstract
Powder-Based Processing and Modelling is an enabling fundamental research theme in Materials, encompassing applications in nanotechnologies, electronics, energy and biotechnologies. This Platform Grant aims to further advance our innovative processing techniques in powder ink-jet, electrohydrodynamic jetting, filament freeforming, and dry-powder dispensing, with high-throughput capabilities for materials discovery; and apply such techniques to clean energy generation / storage and to biomaterials /structures. Multiscale materials modelling techniques will continue to be developed and applied for the design and development of materials structures and systems for such applications. This intercollegiate collaborative research platform will consolidate the integration of research strengths in powder processing and modelling from both QMUL and UCL for much added value. It will also enhance our international stance and recognition in the research theme, and facilitate strategic changes of our research, directing them into tangible applications towards energy, security, and biomaterials, some of the pressing challenges of our age. Specifically, we have identified ways of refining the resolution of dry powder dispensing in solid freeforming by ultrasonic actuation and laser guidance and in filamentary solid freeforming methods by extrusion through <50 ?m dia dies and by electrohydrodynamic jetting, micro-threading and electrospinning of ceramics. We are now running a working thick-film combinatorial robot for ceramics. We will apply these techniques to biomedical applications such as tissue engineering and maxillofacial scaffold construction; to clean energy technologies including electrodes for biofuel cells, novel structures for high capacity and heat-management in hydrogen storage, photoelectrocatalysis, and THz energy-efficient metamaterials. These represent some of the priority research themes of our time, where the proposed platform programme in highly innovative areas of powder processing can make significant contributions.
Organisations
People |
ORCID iD |
| Mohan Edirisinghe (Principal Investigator) |
Publications
Ahmad Z
(2009)
Novel preparation of transdermal drug-delivery patches and functional wound healing materials.
in Journal of drug targeting
Ahmad Z
(2008)
Deposition of nano-hydroxyapatite particles utilising direct and transitional electrohydrodynamic processes.
in Journal of materials science. Materials in medicine
Ahmad Z
(2009)
Engineering a material for biomedical applications with electric field assisted processing
in Applied Physics A
Ahmad Z
(2008)
Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow.
in Journal of the Royal Society, Interface
Bakhshi P
(2012)
Application of Electrohydrodynamic Technology for Folic Acid Encapsulation
in Food and Bioprocess Technology
Bakhshi PK
(2016)
Manufacturing Man-Made Magnetosomes: High-Throughput In Situ Synthesis of Biomimetic Magnetite Loaded Nanovesicles.
in Macromolecular bioscience
Brako F
(2017)
Application of nanotechnology for the development of microbicides.
in Nanotechnology
Brako F
(2015)
Making nanofibres of mucoadhesive polymer blends for vaginal therapies
in European Polymer Journal
Chang M
(2009)
A novel process for drug encapsulation using a liquid to vapour phase change material
in Soft Matter
Chang MW
(2011)
Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules.
in Journal of the Royal Society, Interface
Chang MW
(2010)
Controlling the thickness of hollow polymeric microspheres prepared by electrohydrodynamic atomization.
in Journal of the Royal Society, Interface
Chang MW
(2010)
A new method for the preparation of monoporous hollow microspheres.
in Langmuir : the ACS journal of surfaces and colloids
Enayati M
(2011)
Electrohydrodynamic preparation of particles, capsules and bubbles for biomedical engineering applications
in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Enayati M
(2010)
Size mapping of electric field-assisted production of polycaprolactone particles.
in Journal of the Royal Society, Interface
Enayati M
(2009)
Preparation of polymeric carriers for drug delivery with different shape and size using an electric jet.
in Current pharmaceutical biotechnology
Farook U
(2009)
Stability of microbubbles prepared by co-axial electrohydrodynamic atomisation.
in European biophysics journal : EBJ
Farook U
(2009)
Preparation of suspensions of phospholipid-coated microbubbles by coaxial electrohydrodynamic atomization.
in Journal of the Royal Society, Interface
Farook U
(2008)
Novel co-axial electrohydrodynamic in-situ preparation of liquid-filled polymer-shell microspheres for biomedical applications.
in Journal of microencapsulation
Labbaf S
(2013)
An encapsulated drug delivery system for recalcitrant urinary tract infection
in Journal of The Royal Society Interface
Labbaf S
(2014)
Preparation of multilayered polymeric structures using a novel four-needle coaxial electrohydrodynamic device.
in Macromolecular rapid communications
Mahalingam S
(2015)
Formation of protein and protein-gold nanoparticle stabilized microbubbles by pressurized gyration.
in Langmuir : the ACS journal of surfaces and colloids
Mahalingam S
(2015)
Solubility-spinnability map and model for the preparation of fibres of polyethylene (terephthalate) using gyration and pressure
in Chemical Engineering Journal
Mahalingam S
(2015)
Antibacterial Activity and Biosensing of PVA-Lysozyme Microbubbles Formed by Pressurized Gyration
in Langmuir
MUNIR G
(2012)
ELECTROHYDRODYNAMIC PROCESSING OF CALCIUM PHOSPHATES: COATING AND PATTERNING FOR MEDICAL IMPLANTS
in Nano LIFE
Muthutantri A
(2008)
Novel preparation of graded porous structures for medical engineering.
in Journal of the Royal Society, Interface
Muthutantri AI
(2008)
Dipping and electrospraying for the preparation of hydroxyapatite foams for bone tissue engineering.
in Biomedical materials (Bristol, England)
Nangrejo M
(2010)
Ceramic encapsulation with polymer via co-axial electrohydrodynamic jetting.
in Journal of microencapsulation
Nangrejo M
(2009)
Electrohydrodynamic forming of porous ceramic capsules from a preceramic polymer
in Materials Letters
Nangrejo M
(2010)
Generation of ceramic-ceramic layered composite microstructures using electrohydrodynamic co-axial flow
in Ceramics International
Nithyanandan A
(2015)
Bioinspired electrohydrodynamic ceramic patterning of curved metallic substrates
in Bioinspired, Biomimetic and Nanobiomaterials
Nithyanandan A
(2013)
Template-assisted electrohydrodynamic atomization of polycaprolactone for orthopedic patterning applications.
in Materials science & engineering. C, Materials for biological applications
Pancholi K
(2008)
Dynamics of bubble formation in highly viscous liquids.
in Langmuir : the ACS journal of surfaces and colloids
Pancholi K
(2009)
Novel electrohydrodynamic preparation of porous chitosan particles for drug delivery.
in Journal of materials science. Materials in medicine
Raimi-Abraham BT
(2015)
Development and Characterization of Amorphous Nanofiber Drug Dispersions Prepared Using Pressurized Gyration.
in Molecular pharmaceutics
Stride E
(2008)
Increasing the nonlinear character of microbubble oscillations at low acoustic pressures.
in Journal of the Royal Society, Interface
Stride E
(2009)
Novel preparation techniques for controlling microbubble uniformity: a comparison.
in Medical & biological engineering & computing
Thian E
(2011)
Electrospray deposition of nanohydroxyapatite coatings: A strategy to mimic bone apatite mineral
in Thin Solid Films
Thian ES
(2010)
The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts.
in Acta biomaterialia
Wu X
(2017)
New Generation of Tunable Bioactive Shape Memory Mats Integrated with Genetically Engineered Proteins.
in Macromolecular bioscience
Xu Z
(2016)
Making Nonwoven Fibrous Poly(e-caprolactone) Constructs for Antimicrobial and Tissue Engineering Applications by Pressurized Melt Gyration
in Macromolecular Materials and Engineering
Xu Z
(2015)
Physio-chemical and antibacterial characteristics of pressure spun nylon nanofibres embedded with functional silver nanoparticles.
in Materials science & engineering. C, Materials for biological applications
Zhang S
(2015)
Coupling Infusion and Gyration for the Nanoscale Assembly of Functional Polymer Nanofibers Integrated with Genetically Engineered Proteins.
in Macromolecular rapid communications
| Description | This Platform Grant significantly advanced our innovative processing techniques, particularly in electrohydrodynamic jetting for the preparation of biomedically useful structures and those that can be of utilitarian value in food engineering. It also uncovered new generic principles in the electric jetting viscous materials suspensions and liquids. Even today, it continues to generate new manufacturing technology, e.g. gyratory fibre spinning technologies. |
| Exploitation Route | For making microbubbles, capsules, particles and fibres which push the frontiers of medical engineering and food engineering forward. |
| Sectors | Agriculture Food and Drink Chemicals Creative Economy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | https://www.edirisinghelab.com/ |
| Description | Findings have been useful in uncovering a new process for microbubble preparation, this work won the EPSRC-Royal Society Journal Interface best paper award in 2009. Many innovative manufacturing routes involving microfluidics, electrohydrodynamics, their combinations, gyratory technologies have evolved from this platform grant and all two recent major awards: The Institute of Materials, Minerals and Mining Chapman Medal for distinguished research in the field of biomedical materials, 2017 The Royal Academy of Engineering Armourers & Brasiers Compnay Prize for excellence in materials engineering, 2017 |
| First Year Of Impact | 2009 |
| Sector | Agriculture, Food and Drink,Chemicals,Creative Economy,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal Economic |
| Description | Danish Research Agency |
| Amount | £32,000 (GBP) |
| Funding ID | 000002040 Industrial PhD project award |
| Organisation | Danish Agency for Science, Technology and Innovation |
| Sector | Public |
| Country | Denmark |
| Start | 09/2010 |
| End | 09/2013 |
| Description | EPSRC Follow-on |
| Amount | £99,000 (GBP) |
| Funding ID | EP/J01334X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2012 |
| End | 09/2013 |
| Description | EPSRC Follow-on |
| Amount | £128,000 (GBP) |
| Funding ID | EP/H007342/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2009 |
| End | 08/2010 |
| Description | EPSRC Responsive Mode |
| Amount | £151,000 (GBP) |
| Funding ID | EP/I032355/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2012 |
| End | 03/2014 |
| Description | Leverhulme Trust |
| Amount | £87,000 (GBP) |
| Funding ID | F/07 134/DG |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 09/2011 |
| Description | Unilever |
| Amount | £90,000 (GBP) |
| Funding ID | Case Studentship - 10000856 |
| Organisation | Unilever |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 04/2014 |
| Company Name | AtoCap |
| Description | AtoCap develops technology which processes electrically charged fluids and enables the creation of drug capsules for use within the chemical, pharmaceutical and cosmetic industries. |
| Year Established | 2011 |
| Impact | Won £25000 Venture Prize from The Worshipful Company of Armourers & Brasiers |
| Website | http://atocap.com |