A 500MHz NMR Spectrometer to Underpin Chemical Research at Bristol (invited resubmission)

Lead Research Organisation: University of Bristol
Department Name: Chemistry


This proposal is concerned with the purchase and installation of scientific hardware that will be essential to the long term analysis of chemical problems at the University of Bristol. NMR spectroscopy is a technique that underpins nearly all apects of modern chemical analysis - from biological through materials to synthetic studies. It allows the elucidation of composition, structure and motion in chemical samples, leading to a fundamental understanding of molecular characteristics in these nano-scale systems. For example the School of Chemistry applies this technique to analysis of complex biologically active compounds isolated from natural sources, products of interest to the pharmaceutical and petrochemical industries, new materials relevant to nanoscience, biotechnology, monitoring complex chemical reactions, elucidation of novel structures produced in chemical synthesis and complex chemical catalysis. To these ends, NMR spectroscopy underpins the work of over 250 research workers, with national and international links to a range of academic and industrial applications. The NMR Facility within the School of Chemistry at Bristol University currently employs 5 instruments ranging from 7-23 years old with resolutions of 270-400MHz to conduct such chemical analysis. The increasing requirements of the high-level research undertaken in the School demand access to resolutions and sensitivity from fields >400MHz.The new instrument requested in the proposal will facilitate new and cutting edge developments in a number of areas as well as ensuring support for current levels of research in the School.The new 500 MHz machine will enable the study of of metabolic products, catalyst mechanisms, natural product structures, functional polymers, protein dynamics, ion-sensors and an array of other materials at down to microgram levels which hitherto have been inaccessible to the researchers in the School.


10 25 50

publication icon
Butts CP (2011) High precision NOEs as a probe for low level conformers--a second conformation of strychnine. in Chemical communications (Cambridge, England)

Description Significan new information on meechanisms of polyketide biosynthesis
Exploitation Route Ongoing area of wide international activity so our results will influence work of others
Sectors Chemicals

Pharmaceuticals and Medical Biotechnology

Description Methods for the determination of the molecular structures of compounds are disclosed, the methods comprising obtaining NMR spectroscopic measurements of compounds, determining internuclear distances from the NMR measurements, and inputting the distances to an algorithm to determine probable structures. Optionally, constraints may be added and the algorithm repeated. Usually, the methods do not require comparisons to databases of spectra during the generation of possible structures. 
IP Reference WO2010026418 
Protection Patent granted
Year Protection Granted 2010
Licensed No