Metathesis Reactions as the Basis for Construction of Aromatic Compounds: Application to Both Methodology and Synthesis
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new type of catalyst. The molecules at the heart of the proposal are aromatic compounds which have special properties and are the building blocks of most known pharmaceutical agents. Therefore, it is imperative that we have novel, efficient and powerful methods for making new aromatic compounds so that we can study and use them. In addition, the development of new catalysts is also important because it makes chemical reactions run faster, cleaner and with less waste: this is clearly a good thing for industry and also for the environment.
People |
ORCID iD |
Timothy Donohoe (Principal Investigator) |
Publications

Donohoe T
(2009)
Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines
in Tetrahedron

Donohoe TJ
(2010)
An expedient route to substituted furans via olefin cross-metathesis.
in Proceedings of the National Academy of Sciences of the United States of America

Donohoe TJ
(2010)
Substituted pyrroles via olefin cross-metathesis.
in Organic letters

Donohoe TJ
(2010)
Olefin cross-metathesis-based approaches to furans: procedures for the preparation of di- and trisubstituted variants.
in Nature protocols

Donohoe TJ
(2009)
Synthesis of substituted pyridines and pyridazines via ring closing metathesis.
in Chemical communications (Cambridge, England)
Description | New routes to aromatic compounds using catalysis based on ruthenium. |
Exploitation Route | Development of efficient routes to compounds of interest, especially those with bioactivity. |
Sectors | Pharmaceuticals and Medical Biotechnology |
Description | Development of efficient routes to compounds of interest; access to previously unobtainable compounds. |
First Year Of Impact | 2010 |
Sector | Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Description | EPSRC |
Amount | £218,279 (GBP) |
Funding ID | EP/H051058/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2011 |
End | 07/2013 |