Application of a High Field and High Resolution MRI to Tribological Studies of Articular Cartilage

Lead Research Organisation: University of Leeds
Department Name: Mechanical Engineering

Abstract

Understanding the lubrication mechanism in healthy synovial joints such as hips and knees is important for not only understanding how these natural bearings operate in the human body but also developing intervention therapies. The unique load bearing material of articular cartilage in synovial joints is porous and elastic filled with water. Under loading, the interstitial water flows and supports a large percentage of external loading. The aims of this proposal are to develop and apply an advanced high resolution MRI to the lubrication studies of articular cartilage. The main objectives include the development of the MRI imaging methodology and design and development of a small scale experimental lubrication rig to be used inside the MRI to measure deformation, friction and wear. Once these methodologies are developed, applications will be made on both normal and degenerated tissues. Understanding the fluid flow and lubricating capacity for healthy and degenerated cartilage specimens in a range of loading conditions is important as cartilage substitution interventions and tissue engineering therapies are being developed. The outcome from the proposed research will provide timely guidelines for pre-clinical evaluation of these treatment options, and provide knowledge for the regulatory and standards bodies. This will have tremendous economic benefits to the UK NHS as well as clinical benefits to patients.

Publications

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Hogg P (2015) Development of a terminally sterilised decellularised dermis. in Cell and tissue banking

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Maiti R (2014) The influence of kinematic conditions and design on the wear of patella-femoral replacements. in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

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Li J (2014) Biphasic investigation of contact mechanics in natural human hips during activities. in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

 
Description Structure of meniscus defined by high resolution MRI
Exploitation Route Support for developemnt acellular biological scafolds
Sectors Healthcare

 
Description Biocomposites
Amount £200,000 (GBP)
Funding ID LMJ 
Organisation Biocomposites 
Sector Private
Country United Kingdom
Start 01/2013 
End 01/2016
 
Description DTC 208-2017
Amount £7,000,000 (GBP)
Funding ID DTC 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2008 
End 09/2017
 
Description DTP
Amount £2,000,000 (GBP)
Funding ID DTP 
Organisation DePuy Synthes 
Sector Private
Country United States
Start 01/2014 
End 01/2016
 
Description EPSRC cartilage programme
Amount £4,600,000 (GBP)
Funding ID EPG01121721 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2009 
End 06/2015
 
Description European Research Council advanced award
Amount £2,000,000 (GBP)
Funding ID Proposal 267114 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 04/2011 
End 04/2016
 
Description IKC
Amount £10,000,000 (GBP)
Funding ID "EP G0324831, EPI0191031, EPJ0176201" 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2009 
End 04/2016
 
Description LMBRU 2007 12
Amount £6,700,000 (GBP)
Funding ID LMBRU 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2007 
End 04/2012
 
Description NHSBT
Amount £200,000 (GBP)
Funding ID EI 
Organisation NHS Blood and Transplant (NHSBT) 
Sector Public
Country United Kingdom
Start 01/2014 
End 01/2017
 
Description Tissue regenix
Amount £60,000 (GBP)
Funding ID EI 
Organisation Tissue Regenix Ltd 
Sector Private
Country United Kingdom
Start 01/2016 
End 01/2018
 
Description invibio
Amount £400,000 (GBP)
Funding ID LMJ 
Organisation Invibio 
Sector Private
Country United Kingdom
Start 01/2014 
End 12/2016
 
Description mathys
Amount £400,000 (GBP)
Funding ID LMJ 
Organisation Mathys 
Sector Private
Country Switzerland
Start 01/2014 
End 01/2016
 
Description senior investigator
Amount £100,000 (GBP)
Funding ID LMBRU 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 04/2015