Lymphocyte Kinetics in Health and Disease: a workshop

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

Immune cell dynamics are a crucial determinant of human health. The correct balance between immune cell proliferation and death guarantees a functioning immune system that contains cells of sufficient range and quantity to be able to recognize and destroy all pathogens. Dysregulation of the dynamic balance underpins many pathologies including AIDS (immune cell depletion) and leukemia (aberrant immune cell growth). Understanding immune cell dynamics is therefore a prerequisite for understanding the human immune system both in health and disease.In the last 10 years significant advances in experimental techniques and in the mathematics needed to interpret these experiments have enabled the measurement of immune cell dynamics in humans. However, different mathematical and experimental techniques can give significantly different answers. To date, there is no consensus on which techniques should be used. Modelling of immune cell dynamics is an intrinsically interdisciplinary subject. There is currently no forum to discuss the modeling of immune cell dynamics and so mathematicians and experimentalists attend their single subject-specific conferences and have little opportunity to meet. The aim of this two day interdisciplinary workshop is to bring together mathematicians and immunologists who are experts in immune cell dynamics with a view to exchange ideas, disseminate knowledge, initiate collaborations and ultimately to reach a consensus on the optimal mathematical and experimental techniques.

Publications

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Asquith B (2009) Lymphocyte kinetics in health and disease. in Trends in immunology

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N/a Asquith (2009) Lymphocyte kinetics in health and disease in Trends in Immunology

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Laydon DJ (2014) Quantification of HTLV-1 clonality and TCR diversity. in PLoS computational biology

 
Description We received £3,453 to cover costs for international speakers at a two day workshop we organised entitled "Lymphocyte Kinetics in Health and Disease". The workshop was held in London 2008.



The two day interdisciplinary workshop provided a unique forum where both mathematicians and

experimentalists could discuss the modeling of immune cell dynamics. This enabled experts in immune cell dynamics to

exchange ideas, disseminate knowledge, initiate collaborations and move towards a consensus on the optimal

mathematical and experimental techniques. 120 people participated in the workshop which was fully subscribed.

Participants originated from around the world and had a broad range of backgrounds with a roughly 60:40 split between

theorists/ mathematicians and experimentalists; both industry and academia were well represented.
Exploitation Route An innovative, vigorous science base is essential for the prosperity of the UK and global economies. Interdisciplinary work produces some of the most novel, most exciting science: it invigorates the science base and produces the next generation of scientists, techniques and innovations. This workshop helped to build the interdisciplinary science sector in the UK. * Participants reported a number of collaborations and grant applications arising as a direct result of the workshop

* A paper, written by the scientific organisers, discussing the key topics presented has been published in Trends in Immunology

* We were invited to contribute a book chapter on the subject of lymphocyte dynamics.

* Both informal and formal feedback about the event was very positive.
Sectors Education,Financial Services/ and Management Consultancy,Pharmaceuticals and Medical Biotechnology

 
Description Royal Free Hampstead NHS Trust 
Organisation Royal Free London NHS Foundation Trust
Country United Kingdom 
Sector Charity/Non Profit 
Start Year 2008
 
Description St George's University of London 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
Start Year 2008
 
Description University Medical Centre 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
Start Year 2008
 
Description University of Utrecht 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
Start Year 2008
 
Description collaboration 
Organisation National Institute for Health Research
Country United Kingdom 
Sector Public 
PI Contribution 2) An international collaboration to investigate models of T lymphocyte recirculation, was established at the workshop. It involves the University of Rome and the National Institute of Health, USA. Further meetings on the subject of modelling T lymphocytes have taken place in late 2008, and a grant proposal is currently being constructed.
Start Year 2009
 
Description collaboration 
Organisation Sapienza University of Rome
Country Italy 
Sector Academic/University 
PI Contribution 2) An international collaboration to investigate models of T lymphocyte recirculation, was established at the workshop. It involves the University of Rome and the National Institute of Health, USA. Further meetings on the subject of modelling T lymphocytes have taken place in late 2008, and a grant proposal is currently being constructed.
Start Year 2009
 
Description collaboration 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution 1) A collaboration, set up during the workshop, has discussed reconciling the different results obtained from labelling techniques. A publication is in preparation. This international collaboration involved St Georges, University of London, Imperial College London, and University of Utrecht.
 
Description collaboration 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution 1) A collaboration, set up during the workshop, has discussed reconciling the different results obtained from labelling techniques. A publication is in preparation. This international collaboration involved St Georges, University of London, Imperial College London, and University of Utrecht.
 
Description collaboration (3) 
Organisation Maidstone and Tunbridge Wells NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution A collaboration, originating in the workshop, resulted in an exchange of data and techniques between colleagues from Maidstone & Tunbridge Wells NHS Trust and the University of Leeds.
Start Year 2009
 
Description collaboration (3) 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution A collaboration, originating in the workshop, resulted in an exchange of data and techniques between colleagues from Maidstone & Tunbridge Wells NHS Trust and the University of Leeds.
Start Year 2009