Electronic Sonotweezers: Particle Manipulation with Ultrasonic Arrays
Lead Research Organisation:
University of Southampton
Department Name: Faculty of Engineering & the Environment
Abstract
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Organisations
- University of Southampton (Lead Research Organisation)
- Defence Science & Technology Laboratory (DSTL) (Collaboration)
- Defence Science and Technology Laboratory (Project Partner)
- Loadpoint (United Kingdom) (Project Partner)
- Piezo Composite Transducers (PCT) Ltd (Project Partner)
- Weidlinger Associates (United States) (Project Partner)
- Danaher (United Kingdom) (Project Partner)
Publications
Bernassau AL
(2014)
Controlling acoustic streaming in an ultrasonic heptagonal tweezers with application to cell manipulation.
in Ultrasonics
Courtney CR
(2010)
Manipulation of microparticles using phase-controllable ultrasonic standing waves.
in The Journal of the Acoustical Society of America
Glynne-Jones P
(2013)
Efficient finite element modeling of radiation forces on elastic particles of arbitrary size and geometry.
in The Journal of the Acoustical Society of America
Qiu Y
(2014)
Acoustic Devices for Particle and Cell Manipulation and Sensing
in Sensors
Tait A
(2019)
Engineering multi-layered tissue constructs using acoustic levitation.
in Scientific reports
Lei J
(2016)
Modal Rayleigh-like streaming in layered acoustofluidic devices
in Physics of Fluids
Hill M
(2016)
A One-Sided View of Acoustic Traps
in Physics
Lei J
(2017)
Transducer-Plane Streaming Patterns in Thin-Layer Acoustofluidic Devices
in Physical Review Applied
Lei J
(2017)
Comparing methods for the modelling of boundary-driven streaming in acoustofluidic devices.
in Microfluidics and nanofluidics
Lei J
(2014)
Numerical simulation of 3D boundary-driven acoustic streaming in microfluidic devices.
in Lab on a chip
Li S
(2014)
Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering.
in Lab on a chip
Lei J
(2013)
Acoustic streaming in the transducer plane in ultrasonic particle manipulation devices.
in Lab on a chip
Glynne-Jones P
(2013)
Acoustofluidics 23: acoustic manipulation combined with other force fields.
in Lab on a chip
Gedge M
(2012)
Acoustofluidics 17: theory and applications of surface acoustic wave devices for particle manipulation.
in Lab on a chip
Glynne-Jones P
(2012)
Acoustofluidics 9: Modelling and applications of planar resonant devices for acoustic particle manipulation.
in Lab on a chip
Jonnalagadda US
(2018)
Acoustically modulated biomechanical stimulation for human cartilage tissue engineering.
in Lab on a chip
Glynne-Jones P
(2012)
Array-controlled ultrasonic manipulation of particles in planar acoustic resonator.
in IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Carugo D
(2011)
Contrast agent-free sonoporation: The use of an ultrasonic standing wave microfluidic system for the delivery of pharmaceutical agents.
in Biomicrofluidics
Mishra P
(2014)
Deformation of red blood cells using acoustic radiation forces.
in Biomicrofluidics
Tait A
(2015)
Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines.
in Biomaterials
Mulvana H
(2013)
Ultrasound assisted particle and cell manipulation on-chip.
in Advanced drug delivery reviews
| Description | Across the consortium as a whole we have developed new ways of using ultrasonics to manipulate particles and cells in a much more dexterous way than was previously possible. In Southampton in particular, the technologies have been used for growing human cartilage tissue in a special bioreactor that levitates the cells and stimulates them mechanically. We have also shown that the technology can be used to grow layered tissue structures outside of the body and are developing this further for studying cell behaviour in conditions such as asthma. |
| Exploitation Route | We are developing the cartilage work for use with stem cells and we believe that the layered tissue constructs have the potential to replace animal experiments in some stages of research into lung pathologies. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | The work has provoked significant media interest across the consortium as a whole. The Southampton work has led to several media interviews and subsequently to setting up displays to exhibit the underlying technology for public engagement. This has been included in many events including the Royal Society Summer Exhibition and the Cheltenham Science Festival. |
| First Year Of Impact | 2013 |
| Sector | Creative Economy,Other |
| Impact Types | Cultural |
| Description | Application of a custom-built acoustofluidic perfusion bioreactor to model physiological differentiation of human embryonic stem cells and bioengineer neocartilage explants |
| Amount | £64,827 (GBP) |
| Organisation | University of Southampton |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2015 |
| End | 09/2018 |
| Description | Application of a custom-built acoustofluidic perfusion bioreactor to model physiological differentiation of human embryonic stem cells and bioengineer neocartilage explants |
| Amount | £29,799 (GBP) |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | Aquality |
| Amount | £199,844 (GBP) |
| Funding ID | 286601 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2012 |
| End | 11/2013 |
| Description | Development of a human tissue based model of the airway using cell sheet engineering. |
| Amount | £80,000 (GBP) |
| Organisation | Wessex Medical Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 09/2019 |
| Description | High-throughput Optical Blood Imaging for the Detection of Rare Cells using Ultrasonic Particle Alignment |
| Amount | £94,181 (GBP) |
| Funding ID | EP/K027115/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 12/2014 |
| Description | Ultrasonic, microfluidic HPLC-chip and mass spectrometry technologies |
| Amount | £50,000 (GBP) |
| Organisation | Agilent Technologies |
| Sector | Private |
| Country | United States |
| Start | 09/2012 |
| End | 04/2013 |
| Description | DSTL Porton Down |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Continued development of bacterial detection methods of interest to DSTL |
| Collaborator Contribution | Support with technical advice, attendance at meetings and provision of samples. |
| Impact | Multidisciplinary - Engineering and Biotechnology. Early engagement with DSTL contributed to the establishment of the DSTL spinout ProKyma |
| Start Year | 2006 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 6000 visitors interacted with our exhibits focussed on the biological applications of acoustic particle manipulation. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.cheltenhamfestivals.com/science |
| Description | Media Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Live radio interview with BBC Radio Solent. Early evening show 09/06/2014 |
| Year(s) Of Engagement Activity | 2014 |
| Description | Press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release entitled "Southampton researchers help develop gravity-defying ultrasonic tweezers that could lead to life-changing medical advances". Led to further media enquiries |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.southampton.ac.uk/engineering/news/2014/06/03_ultrasonic_tweezers.page |
| Description | Royal Society Summer Science Exhibition 2014 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 15,000 members of the public visited our exhibit at Royal Society Summer Science Exhibition 2014, "The hidden world of ultrasonic waves". |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://royalsociety.org/summer-science/ |