E-TERM, Engineering Tissue Engineering and Regenerative Medicine

Lead Research Organisation: Loughborough University
Department Name: Wolfson Sch of Mech, Elec & Manufac Eng

Abstract

Continued improvement in the nation's health depends upon the efficient development of affordable replacement human tissue and related therapies; an acute shortage of willing organ donors and the shortcomings of conventional therapies leads to the preventable death of many patients each year. The next healthcare revolution will apply regenerative medicines, creating biological therapies or substitutes for the replacement or restoration of tissue function lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is now a need for the long term supply of people properly trained with the necessary skills to lead the engineering and life science challenges before the predicted benefits in human healthcare can be realised. Realisation of these benefits requires a new generation of translational professional leaders immersed in both the fundamental science of these new products and the clinical, engineering and commercial realities of their creation and application.This proposal brings together for the first time the six University teams, and the associated growing cohorts of young researchers, involved in the two Regenerative Medicine DTCs funded through the EPSRC Life Sciences Interface Programme. Each University group is independently internationally leading in their field, and has attracted significant funding from the EPSRC Life Sciences Interface Programme and elsewhere. The proposed Landscape Award offers the opportunity to combine the research strengths of the six groups to deliver a strategic collaborative programme of cross-disciplinary research, and a cohort of future research leaders in tissue engineering and regenerative medicine. The proposed research programme is truly cross-disciplinary, requiring expertise that ranges from fundamental cell biology, through biological engineering, biomechanics and tissue engineering, to bioprocessing, regulated manufacturing, and commercialisation.

Planned Impact

Undertaking and ensuring impact activities is integral to the vision and operational processes of the academic groups. We are fortunate that the research portfolios at each of the six universities are user-driven, and in many cases industry led - the focus is on a balance between academic excellence and early industrial relevance. Both DTCs, the Loughborough-led EPSRC Centre for Innovative Manufacturing in Regenerative Medicine, and the Leeds based IKC in Regenerative Therapies and Devices all have established strategies, mechanisms and expert staff for the exploitation of research. The effectiveness of these exploitation strategies is illustrated by the growing number of products and spin-out companies associated with the academic partners. It is our belief and intention that all team members participate in assisting impact. The teams involved in both DTCs have wide experience of managing large and high profile projects and in undertaking impact activities and knowledge transfer at all levels and stakeholder targets. The Landscape Award proposed here has three fundamental deliverables, each of which has highly significant impact across a range of beneficiaries: - a programme of fundamental cross-disciplinary research in tissue engineering and regenerative medicine (TERM) that addresses technological challenges in the translation of promising science to practical therapeutics. Here the impact is geared toward the realisation of regenerative medicine as a viable and wealth-creating industry, the provision of new therapies for use by clinicians, and the promise for patients of new treatments for currently unmet and prevalent chronic conditions. -the identification and nurturing of future research leaders in TERM capable of ensuring the delivery of the potential of RM be this in industry, the public sector, or in academia. -the establishment of a new collaborative research environment between six world leading UK groups based in UK Universities in the fields of tissue engineering and regenerative medicine. Such collaboration will catalyse and accelerate new and ground-breaking advances in both fundamental understanding, and in the translation of that knowledge into everyday healthcare practice. The Landscape Executive Group will regularly review impact made, and the efforts by all associated with the two DTCs to achieve impact. All Fellows projects will have a potential impact analysis and action plan for its execution, and Fellows will receive training as needed to ensure they have the relevant skills. Importantly, as impact activities are an integral part of the working of the two DTCs academic partners, no significant additional financial resource is required.

Publications

10 25 50
 
Title Videos representing Big Data 
Description Through collaboration with a graphics designer, Sarah Bates, Leeds College of Art, we created videos from gene array data to represent the data to the general public in a more engaging manner. 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact From the creative representation of the data we were able to pull out analyses not previously seen through traditional methods. 
 
Description The two Regenerative Medicine DTC's have been fortunate to secure in collaboration twelve, two year, early career fellowships from EPSRC in the E-TERM, Engineering Tissue Engineering and Regenerative Medicine, Landscape Fellowship Programme. These fellowships are intended to develop promising young interdisciplinary research leaders. We recruited 12 fellows. Fellows worked on products for ophthalmic use; cartilage, cardiac and neural tissue engineering including spinal cord repair; and immunological, materials, and manufacturing and scale up issues. They both worked as individual independent researchers supported by mentored personal development and working together as a cadre. They also made significant contributions to the DTC's, primarily by the organisation of specialist workshops focussing on timely issues - these have included regulation, pre-clinical models and mesenchymal stem cell technologies. As it closed the programme organised an early career researchers conference, the results this have included policy influencing via input to national consultations, and a study visit to Boston particularly aimed at strengthening the networks of the last group of fellows.
Exploitation Route Fellowships are translational and individual project findings are taken forward by individual fellows via industrial or clinical collaborations. The fellows have worked together on a publication summarising successful ways of working, "tricks of the trade", for engineering-based tissue engineering and regenerative medicine translational research.
Sectors Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL http://www.epsrc-regen-med.org/research/e-term-fellowships/
 
Description ETERM allowed the appointment of twelve two year translational fellowships, two more fellows than was initially anticipated. The ETERM Fellows as a group published a paper "The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products" in 2015 and held a major conference in April 2017 with the aim of setting the direction for translational research in ETERM and of influencing policy. Also the fellows each have their own pathways for impact and will also carry the new knowledge and understanding into their future careers. In addition EPSRC and others are improving their approach to the development of independent early career researchers from the learnings from the Landscape Fellowship programme. Perhaps the most important impact of ETERM is captured by the destination of fellows, ten have secured lectureships, one has secured a Marie Sklodowska Curie Fellowship and one is Business Development Executive for the South of England for the Cell and Gene Therapy Catapult.
First Year Of Impact 2015
Sector Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic,Policy & public services

 
Description ATREUM (Advancing Tissue and Regenerative Engineering in UK Medicine)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact ATREUM was a national conference spearheaded by the ETERM Fellows which brought together regenerative medicine Early Career Researchers with policy makers, funders and regulators to address barriers to research translation in the UK. In addition, the event including training events for early career researchers on skills required to aid clinical translation.
 
Description ATREUM response to the Industrial Strategy Green Paper UK government policy consultation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description ATREUM response to the MHRA Pharmacopeia UK government policy consultation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Coffee and Careers Seminars
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Postgraduate researchers and staff gain information on a variety of careers paths available to them after completing their PhD or research role. Speakers include scientists in industry, operational researchers in civil service, technologists in innovation and tech transfer teams and holders of fellowships and lectureships
 
Description The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Confidence in Concept
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 11/2018
 
Description Daniel Turnberg Travel Fellowship Scheme
Amount £2,900 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 10/2016
 
Description EPSRC Impact Acceleration Account, University of Nottingham. An innovative strategy for vision regeneration using a transplantable tissue-engineered corneal construct
Amount £51,402 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2015
 
Description EPSRC Impact Acceleration account
Amount £96,551 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 04/2017
 
Description Future Investigators in Regenerative Medicine -Travel Award
Amount £800 (GBP)
Organisation Future Investigators in Regenerative Medicine 
Start 09/2014 
End 09/2014
 
Description HERMES travel award
Amount £1,500 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start 04/2013 
End 05/2013
 
Description Industrial Sponsorship
Amount € 4,000 (EUR)
Organisation Aeon Astron B.V. 
Sector Private
Country Netherlands
Start 04/2014 
End 07/2014
 
Description LimbTox: A cornea in a culture dish, as an animal free engineered model for industrial and pre-clinical research
Amount £27,000 (GBP)
Funding ID 13b/I9 
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start 01/2014 
End 06/2014
 
Description MEIbioeng15 conference registration bursary
Amount £200 (GBP)
Organisation MEIbioeng 16 
Sector Learned Society
Country Unknown
Start 09/2015 
End 09/2015
 
Description MRC Confidence in Concept
Amount £74,743 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 02/2018
 
Description Marie Curie Sklodowska Individual Fellowship (Delcassian- DIRECT Therapies)
Amount € 300,000 (EUR)
Funding ID 798348 
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 02/2018 
End 02/2021
 
Description Materials Research Symposium - Best Oral Presentation Prize
Amount $250 (USD)
Organisation Materials Research Society 
Start 10/2014 
End 10/2014
 
Description Small Grant Scheme
Amount £1,800 (GBP)
Organisation British Neuropathological Society 
Sector Learned Society
Country United Kingdom
Start 07/2017 
End 08/2017
 
Description Structural analysis and recellularisation of decellularised corneal scaffolds, Short Scientific Mission in collaboration with Trinity college, Dublin as part of the E-COST Action BM-1302, Joining Forces in Corneal Regeneration Research
Amount € 2,500 (EUR)
Organisation European Cooperation in Science and Technology (COST) 
Department Joining Forces in Corneal Regeneration Research
Sector Public
Country Belgium
Start 11/2014 
End 12/2014
 
Description TCES Travel Award
Amount £150 (GBP)
Organisation Tissue and Cell Engineering Society 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2014 
End 09/2014
 
Description TCES travel award
Amount £150 (GBP)
Organisation TC Education Services 
Sector Academic/University
Country Unknown
Start 06/2013 
End 07/2013
 
Description TCES travel award
Amount £150 (GBP)
Organisation TC Education Services 
Sector Academic/University
Country Unknown
Start 06/2013 
End 07/2013
 
Description The Development of a novel human corneal substitute using Ologen Collagen Matrix, Industrial translational funding from Aeon Astron, Europe
Amount € 4,000 (EUR)
Organisation Aeon Astron B.V. 
Sector Private
Country Netherlands
Start 01/2014 
End 12/2014
 
Description UKRMP Partnership Award- Delcassian Immuno and Acellular Hub to Hub
Amount £50,000 (GBP)
Organisation UK Regenerative Medicine Platform 
Sector Academic/University
Country United Kingdom
Start 02/2016 
 
Description Aeon Astron Industrial visit 
Organisation Aeon Astron B.V.
Country Netherlands 
Sector Private 
PI Contribution 5 day industrial outcome to Aeon Astron in Ledien, Holland to engage in knowledge transfer regarding the regulatory hurdles associated with getting regenerated products to market. In addition, discussion of the use of Ologen collagen matrix, a matrix originally developed for skin models, as a potential corneal substrate. A visit intended to facilitate the the development of pipeline technologies by initiating a collaborative relationship.
Collaborator Contribution I received technical assistance regarding protocols and procedures required for working with Ologen collagen matrix and was involved in meetings where the routes and barriers to marketing a product were discussed. It bought up some important considerations for the future regarding bio burdens and regulatory hurdles.
Impact Strengthening of existing collaboration Knowledge transfer Supply of Ologen matrix
Start Year 2013
 
Description CAR-T Cell Manufacturing Collaboration 
Organisation Akron Biotechnology, LLC
PI Contribution Providing cost of goods insights to a project/manuscript investigating global CAR-T manufacturing.
Collaborator Contribution Provided global perspective and hands on clinibal and commercial data on CAR-t and manufacturing.
Impact to come.
Start Year 2017
 
Description CAR-T Cell Manufacturing Collaboration 
Organisation Massachusetts Institute of Technology
Department Industrial Performance Center
PI Contribution Providing cost of goods insights to a project/manuscript investigating global CAR-T manufacturing.
Collaborator Contribution Provided global perspective and hands on clinibal and commercial data on CAR-t and manufacturing.
Impact to come.
Start Year 2017
 
Description CAR-T Cell Manufacturing Collaboration 
Organisation University of Pennsylvania
Department Perelman School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Providing cost of goods insights to a project/manuscript investigating global CAR-T manufacturing.
Collaborator Contribution Provided global perspective and hands on clinibal and commercial data on CAR-t and manufacturing.
Impact to come.
Start Year 2017
 
Description Collaboration with Jichi Medical University 
Organisation Jichi Medical University
Country Japan 
Sector Academic/University 
PI Contribution Grant writing
Collaborator Contribution Grant writing
Impact Funding acquisition
Start Year 2016
 
Description Collaboration with PhaseFocus Ltd 
Organisation Phase Focus
Country United Kingdom 
Sector Private 
PI Contribution Use of MSC cell lines to collect data for optimisation on Phase Focus Livecyte imaging and analysis system
Collaborator Contribution Free use of beta version on Livecyte system to perform label free automated cell tracking on MSC behaviour
Impact Data has been presented at ARUK Tissue Engineering Group Meetings, and selected for paper presentations at the 2017 UK MSC Conference and the 2017 White Rose Biomaterials and Tissue Engineering Group Meeting, winning second best oral presentation at the latter.
Start Year 2016
 
Description ETERM Secondment to the Canada Centre for Regenerative Medicine 
Organisation Centre for Commercialization of Regenerative Medicine
PI Contribution Seconded to the Canada Centre for Regenerative Medicine working on cell manufacturing processing economics for in-house projects. Provided input using my cost of goods modelling expertise.
Collaborator Contribution Provided the case studies and information for the model.
Impact Technical report and a manuscript (under review)
Start Year 2017
 
Description Industrial Placement at The Electrospinning Company 
Organisation The Electrospinning Company
Country United Kingdom 
Sector Private 
PI Contribution Industrial placement at The Electrospinning Company (Oxford) exploring scaling-up procedures
Start Year 2012
 
Description Industrial collaboration - nanoTherics 
Organisation nanoTherics Ltd
Country United Kingdom 
Sector Private 
PI Contribution I have tested the transfection (gene delivery) efficacy of a prototype device, loaned from nanoTherics Ltd. Various vectors, programs and neural cell transplant populations were tested. A report was produced for the company, and following clarification that the prototype device design is covered by patent, the data are being prepared for publication.
Collaborator Contribution Loan of prototype transfection device (motorised magnetic array designed to enhance magnetic nanoparticle-mediated gene delivery to cell transplant populations). Discussions and expertise on magnetics and biophysics, informing the design of experimental protocols.
Impact The possibility of a patent for the prototype device was explored, and it was decided that an existing patent owned by the company (nanoTherics Ltd) would cover the modifications in the prototype tested. Further device modifications have been discussed, and new prototypes designed, with a view to future collaborative testing in the host laboratory (Dr Divya Chari, Keele University). This project was multidisciplinary, involving: Tissue/genetic engineering (cell culture and transfection; Dr S Jenkins, Keele). Neuroscience (advice on neural cell transplantation populations/procedures; Dr S Jenkins, Dr D Chari, Keele). Molecular biology (optimisation of plasmid DNA preparations for transfection; Dr A Fernandes, Keele). Biophysics (interactions between magnetic nanoparticles and magnetic arrays, informing device operation; Prof J Dobson, University of Florida; C Jones, M Subramanian, nanoTherics). Materials chemistry (informing magnetic nanoparticle selection/design and protocols; Dr H Yiu, University of Edinburgh).
Start Year 2012
 
Description Loughborough - University of Birmingham partnership 
Organisation University of Birmingham
Department Institute of Immunology and Immunotherapy
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr. Davies was invited to the University of Birmingham as an honorary visiting fellow by Professor Liam Grover at the School of Chemical Engineering.
Collaborator Contribution Partners provide in kind funding and unlimited access to research facilities.
Impact Continued collaboration and research outputs with Prof. Liam Grover Further collaborations initiated with junior lecturer, Dr. Sophie Cox and Royal Society of Engineering Fellow, Dr. Pola Oppenheimer. MRC Confidence in Concept research grant for pre-translation of Dr. Davies' EPSRC E-TERM project - £75,000 Finalist at the Enterprising Birmingham Innovation 'most innovative idea' award - final pitch to take place on March 29th 2017
Start Year 2016
 
Description MIT ETERM collaboration 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution We have developed the research proposal. We will contribute scientific understanding of the biomaterial interface with clinically relevant cell types. The collaboration strengthens an existing partnership between University of Nottingham and MIT.
Collaborator Contribution MIT have hosted Asha within their lab, with access to equipment and mentorship. The close collaboration will immerse her in the culture that has made MIT one of the best institutions for translational research. The collaboration will hopefully create a bridge for continued research opportunities beyond my project.
Impact Two published journal papers (Biomaterials 2015, COSSMS review 2016). One patent application filed (Nottingham, Sept. 2014).
Start Year 2014
 
Description Nottingham-MIT Delcassian Collaboration 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution Immunmodulatory materials for controlled release of pharmaceuticals have been made by Derfogail Delcassian at Nottingham.
Collaborator Contribution Materials fabricated by Nottingham are being studied in vivo in appropriate diabetes mouse models.
Impact This is a multidisciplinary award, focusing on immunology, engineeing, biomaterials fabrication and characterisation, chemistry. It is too early to describe outcomes.
Start Year 2016
 
Description Nottingham-MIT Delcassian Collaboration 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Immunmodulatory materials for controlled release of pharmaceuticals have been made by Derfogail Delcassian at Nottingham.
Collaborator Contribution Materials fabricated by Nottingham are being studied in vivo in appropriate diabetes mouse models.
Impact This is a multidisciplinary award, focusing on immunology, engineeing, biomaterials fabrication and characterisation, chemistry. It is too early to describe outcomes.
Start Year 2016
 
Description Nottingham-MIT-Boston Children's Hospital- Harvard Medical School- Delcassian JDRF secondment 
Organisation Boston Children's Hospital
Country United States 
Sector Hospitals 
PI Contribution Dr. Delcassian has taken a 12 month secondment during her E-TERM Fellowship, from March 2017-March 2018, to undertake a new position with Boston Children's Hospital and Harvard Medical School. This role sees her leading a Juvenile Diabetes Research Foundation grant and project in the labs of Prof. Dan Anderson and Prof. Bob Langer, and involves co-managing a team of 10 researchers and technicians working on encapsulated cell therapies for Diabetes-1. The work closely aligns with her own research interests to direct immune behaviour in transplant therapies, and is in collaboration with a number of leading Diabetes research groups.
Collaborator Contribution Dr. Delcassian has taken a 12 month secondment during her E-TERM Fellowship, from March 2017-March 2018, to undertake a new position with Boston Children's Hospital and Harvard Medical School. This role sees her leading a Juvenile Diabetes Research Foundation grant and project in the labs of Prof. Dan Anderson and Prof. Bob Langer, and involves co-managing a team of 10 researchers and technicians working on encapsulated cell therapies for Diabetes-1. The work closely aligns with her own research interests to direct immune behaviour in transplant therapies, and is in collaboration with a number of leading Diabetes research groups.
Impact This collaboration has just initiated, expected outputs include publications. This project is multidisicplinary, using chemistry, biology, transplant surgery and diabetes related in vivo models .
Start Year 2017
 
Description Nottingham-MIT-Boston Children's Hospital- Harvard Medical School- Delcassian JDRF secondment 
Organisation Massachusetts Institute of Technology
Department Koch Institute
Country United States 
Sector Academic/University 
PI Contribution Dr. Delcassian has taken a 12 month secondment during her E-TERM Fellowship, from March 2017-March 2018, to undertake a new position with Boston Children's Hospital and Harvard Medical School. This role sees her leading a Juvenile Diabetes Research Foundation grant and project in the labs of Prof. Dan Anderson and Prof. Bob Langer, and involves co-managing a team of 10 researchers and technicians working on encapsulated cell therapies for Diabetes-1. The work closely aligns with her own research interests to direct immune behaviour in transplant therapies, and is in collaboration with a number of leading Diabetes research groups.
Collaborator Contribution Dr. Delcassian has taken a 12 month secondment during her E-TERM Fellowship, from March 2017-March 2018, to undertake a new position with Boston Children's Hospital and Harvard Medical School. This role sees her leading a Juvenile Diabetes Research Foundation grant and project in the labs of Prof. Dan Anderson and Prof. Bob Langer, and involves co-managing a team of 10 researchers and technicians working on encapsulated cell therapies for Diabetes-1. The work closely aligns with her own research interests to direct immune behaviour in transplant therapies, and is in collaboration with a number of leading Diabetes research groups.
Impact This collaboration has just initiated, expected outputs include publications. This project is multidisicplinary, using chemistry, biology, transplant surgery and diabetes related in vivo models .
Start Year 2017
 
Description Short Placement at Ebers Bioreactors 
Organisation Ebers Bioreactors
Country Spain 
Sector Private 
PI Contribution Short placement at Ebers Bioreactors in Zaragoza (Spain) exploring the use of new bioreactor technology
Start Year 2012
 
Description UKRMP Delcassian Immuno-Acellular Hub to Hub Collaboration 
Organisation UKRMP Acellular Hub and UKRMP Immunomodulation Hub (Delcassian)
Country United Kingdom 
Sector Academic/University 
PI Contribution Derfogail Delcassian (E-TERM at Nottingham/UKRMP Acellular Hub) fabricates immunomodulatory biomaterials in controlled release matricies for testing with KCL/UKRMP Immunmodulatory Hub.
Collaborator Contribution The KCL/UKRMP Immunomodulatory Hub (led by Raul Elgueta/Giovanni Lombardi) test materials in mouse models (ie. skin graft) attempting to prolong graft survival.
Impact This collaboration is mutlidisciplinary, including engineering of immunomodulatory materials (Nottingham) and biological testing of immunomodulatory materials in mouse models (Kings College London). It is too early for outputs/outcomes.
Start Year 2016
 
Description University of Nottingham Nanosensors Project 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Worked on manufacturing of nanosensors and imaging. Wrote manuscript and presented at conferences.
Collaborator Contribution Worked on manufacturing of nanosensors and imaging. Wrote manuscript and presented at conferences.
Impact three conference abstracts and two publications so far.
Start Year 2016
 
Description Visit to The University of Keele 
Organisation Keele University
Country United Kingdom 
Sector Academic/University 
PI Contribution Short Visit at The University of keele for exploring the use of a Hydrostatic Bioreactor
Start Year 2013
 
Title COMPOSITION AND METHOD FOR BONE PRODUCTION 
Description The present invention relates to extracellular vesicles derived from osteoblasts or osteoblast-like cells, and in particular to their use in promoting bone growth and repair. 
IP Reference WO2018115871 
Protection Patent granted
Year Protection Granted 2018
Licensed No
Impact Significant media attention. Interaction with commercial sector. Invited presentation at the Cell and Gene Therapy Catapult.
 
Title Composition and method for bone regeneration 
Description A novel biological therapy for hard tissue regeneration with osteoblasts, or osteoblast-like cells, instructed to produce osteogenesis-enhancing extracellular vesicles (EVs) comprising a heterogeneous cargo of biological factors, which can subsequently be isolated and therapeutically administered. Benefits of the technology • Enhanced mineral formation rate, quantity, and quality beyond that of the current clinical gold standard, BMP2. • No risk of phenotypic conversion or teratogenicity upon implantation. • EV production can be scaled up (unlike autograft). • EVs present a more holistic biological approach when compared with the current application of hyper-concentrated growth factors (e.g. BMPs). • EVs are not subject to the same ethical considerations or government regulations as cell-based therapies. 
IP Reference ZSR-1016 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact The award of an MRC Confidence in Concept grant for pre-translational work.
 
Description ATREUM 2017 Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A TERM-focused Early Career Researcher (ECR) conference and workshop, engaging researchers with policy makers, funders, and regulators to set the future scientific direction of UK TERM research.
Year(s) Of Engagement Activity 2017
 
Description Cancer Mini Golf 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Working with a team at the Koch Institute for Integrative Cancer Research, we designed a mini golf course where each hole represented new discoveries in cancer research. Members of the general public played mini-golf to learn about recent research and development in detection techniques and therapies for various types of cancer.
Year(s) Of Engagement Activity 2017
 
Description Coffee and Careers Seminars 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A monthly seminar for Postgraduate Researchers, Post-Docs and Technical Staff in the Department of Biology, University of York. Each month a careers talk is given by an individual with a PhD (usually Alumni) about their career path to date with advice to participants on how to enter this career. Participants comment on their understanding of future career paths and how to get into them.
Year(s) Of Engagement Activity 2014,2015,2016
 
Description Community Outreach and Open Days 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Biotechnology students from European Universities came to visit MIT and discuss entrepreneurship.
Year(s) Of Engagement Activity 2017
 
Description Conference - EuroCell Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Eurocell Meeting - 2nd International Technical Meeting - Processing Challenges in ACI
Year(s) Of Engagement Activity 2015
 
Description Conference - Mercia Stem Cell Alliance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Mercia Stem Cell Alliance Annual Meeting
Year(s) Of Engagement Activity 2015
 
Description Conference - Stem Cells in Regenerative Medicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Stem Cells in Regenerative Medicine - Oswestry Seminar
Year(s) Of Engagement Activity 2015
 
Description E-TERM Translating hMSCs into Therapies Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The workshop, organised by E-TERM Fellow Qasim Rafiq, had over 50 delegates from the UK, EU and US and generated significant discussion around the issues pertaining to translation of human mesenchymal stem cell (hMSC) therapies, highlighting not only the fundamental biology, but also the technical, commercial and clinical challenges. The intention from the outset was to make this workshop discursive where the format was such that following two keynote talks by eminent academics and industrialists, hour-long interactive sessions would ensue providing an opportunity for all delegates to engage, question and discuss topics relevant to them and the issues at hand.

6 keynote talks were organised focusing on the biological, manufacturing, commercialisation and clinical challenges and keynote speakers included Dr Robert Deans (Exec VP Athersys), Dr Brian Hampson (VP PCT), Dr Natalie Mount (Chief Clinical Officer, Cell Therapy Catapult), Dr Karen English (NUI Maynooth), Prof. Frank Barry (NUI Galway) and Prof. David Williams (Loughborough University).

Discussions and topics that would never normally have arisen in a traditional conference setting were explored in some depth with potentially significant outputs. During the course of a discussion on serum-free medium, a key outcome was the development of an academic consortium to arrange the bulk purchase of SFM for academic groups at reduced rates
Year(s) Of Engagement Activity 2014
URL http://www.epsrc-regen-med.org/news/review-of-the-recent-translating-mscs-into-therapies-workshop/
 
Description ETERM Tissue Engineering and Regenerative Medicine OUTREACH workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 2x 1hr outreach session to lower 6th form students (age 16) at Brine Leas, Nantwich.

2x 1hr Tissue Engineering and Outreach sessions delivered to 11 and 14 A-level (age 16) students respectively. Included introduction of "Tissue engineer" terminology that tied in with the Key Stage 5 National Curriculum. Covered stem cells, what they they are capable of and what we are currently able to do with them. Included multiple interactive/debate sessions when covering the ethics of using stem cells.

Pupils enthused about science education.
Year(s) Of Engagement Activity 2013
 
Description Engagement Activity - Royal Society Summer Science Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Team led by Kevin Shakesheff designed and delivered the Biology Builders exhibition during the week-long summer science exhibition.

Engagement of school age learners from across the UK. Engagement of VIPs during evening soiree, including scientific TV personalities.
Year(s) Of Engagement Activity 2013
URL http://www.epsrc-regen-med.org/biologybuilders/
 
Description MIT, Harvard and Sloan Business School Biomedical Entrepreneurship program (Delcassian) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Dr. Delcassian was selected for the MIT, Harvard and Sloan Business School Biomedical Entrepreneurship Program to engage with start ups, industry leaders and commercial investors to evaluate routes to translation in the US biomedical sector.
Year(s) Of Engagement Activity 2016
 
Description Network event with British Consulate Boston 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact UK and Boston based scientists networking event hosted by the British Consulate Boston and funded by EPSRC. Event highlighted translational research being undertaken by the ETERM fellows and brought together local Biotech in Boston to showcase the entrepreneurial environment and highly translational research. CSO of Sigilon, CEO of SuonoBio participated in a panel discussion with Prof David Williams.
Year(s) Of Engagement Activity 2017
 
Description New technique may help damaged eyes regain their sight 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release describing progress to date of one of the techniques used in this grant.

Public awareness of this research increased.
Year(s) Of Engagement Activity 2012
 
Description Pint of Science Outreach Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Each venue in York attracted 30-40 members of the public. In total over the 3 evenings and 4 streams there were over 300 attendees. The festival informed the public about the research that is being undertaken at the University of York and promoted discussions in an informal and relaxed environment.

On a local scale in York the event received high press coverage in the form of numerous radio interviews and newspaper articles. Attendees highly praised the events and requested future events of this nature, covering a wider range of research activities. Pint of Science was used as a case study in the successful bid from the University of York to host the international researchers night in 2014 and 2015.
Year(s) Of Engagement Activity 2013,2014
URL http://www.pintofscience.com/
 
Description Schools Talk - Ashton Sixth Form College - Studying a Year in Industry at Univeristy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Three presentations were delivered to Sixth form students at Aston Sixth Form college on Year in industry programmes whilst at University. The talks also focused on Careers in STEM and my own personal experience of gaining industrial experience. The talk sparked questions from students who had not previously thought about a year in industry during a degree.
Year(s) Of Engagement Activity 2015
 
Description Schools Visit - St Peter's School Stargazing Live 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact An interactive exhibition on Stem Cells and the research into their use in regenerative medicine to reduce the number of total joint replacements. We spoke to pupils engaging them in biological research and to the general public, to explain the hope v's hype of stem cell treatments. We were invited to exhibit after being seen at YorNight and have been asked to help with future events to strengthen the relationship between the school and Biology at the University of York.
Year(s) Of Engagement Activity 2016
URL http://www.stpetersyork.org.uk/st_peters/news_calendar/news/1672_stargazing_live_2016
 
Description Science in Parliament (Delcassian, Westminster, Department of Health) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dr. Delcassian was selected to represent scientists in Parliament, and worked with Director of Research at the Department of Health to identify challenges to UK research translation. Part of the Royal Society Science in Parliament scheme.
Year(s) Of Engagement Activity 2017
 
Description The Sheffield Children Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Interactive stand for children and parents.

Visitors expressed interest in science and research
Year(s) Of Engagement Activity 2012
 
Description US Cell Therapy Site Visits 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact E-TERM Fellow Qasim Rafiq (QR) led a group of 3 PhD students to visit 3 different companies (PCT, Celgene and Irvine Scientific), and incorporated 4 different sites (2 PCT sites, in Mountain View and Allendale). At each company, QR presented an overview of the cell therapy work conducted at Loughborough and more specifically by QR.

Specific outcomes have included:

PCT funding a CDT Regenerative Medicine (Loughborough) studentship on T-cell therapies
PCT hiring a CDT Regenerative Medicine graduate
A signed MOU with Irvine Scientific and significantly reduced rates for Irvine's serum-free medium.
Year(s) Of Engagement Activity 2014
 
Description YorNight Exhibition - 'A joint Endeavour' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interactive exhibition stand as part of European Researchers Night event YorNight. The event was held at various venues across the city, with an estimated attendance of 6000. Our exhibition was a collaboration between the Genever research group at the University of York and Sarah Bates a Graphic Designer studying an MA at Leeds School of Art. Sarah presented large data sets visually through posters and videos. The event as a whole raised the awareness of women in science and the importance of the research York scientists perform.
Year(s) Of Engagement Activity 2015
URL http://yornight.com/2015/