Innovation and Knowledge Centre Regenerative Therapies and Devices Tranche 1 IKC RTD

Lead Research Organisation: University of Leeds
Department Name: Mechanical Engineering

Abstract

The Innovation and Knowledge Centre in Regenerative Therapies and Devices will provide a sustainable platform to address the creation of new technologies in Regenerative Therapies and Devices. It will promote their accelerated adoption, with increased reliability, within a complex global marketplace with increasing cost constraints. Therapies and devices which facilitate the regeneration of body tissues offer the potential to revolutionise healthcare and be a catalyst for economic growth, creating a new business sector within healthcare technology. The IKC RTD will build upon the culture and research landscape of the University and its partners (industry, NHS and intermediaries/users) through the development of new innovation infrastructure and practices which deliver major clinical, health and industry outcomes.In the first year of operation the IKC has:1. Recruited and established a core innovation team to manage and grow the activities of the IKC.2. Established academic supply chain, new centre with 160 researchers.3. Won 50m new research income, funding over 120 research projects.4. Defined a new strategic framework for innovation.5. Established an innovation pipeline with stage gates and criteria for progression.6. Defined and developed the IP portfolio through definition of the unique capabilities.7. Established a pipeline of 63 collaborative innovation projects.8. Engaged with 26 different companies in collaborative innovation projects.9. Established a wider network of 80 plus companies.10. Contributed to nine new products that have reached the market.11. Defined a model for sustainability of IKC RTD.12. Received significant national and global recognition through political visits and extensive media coverage for research and innovation.

Planned Impact

IKC will develop and deliver innovation from fundamental research in regenerative therapies and devices and in broader aspects of medical technolgies. We are curently providing knowledge, unique capabilites and intelellctual assts to 26 companies through 63 collaborative projects, 14 of these companies are new collaborators since the stat of the IKC. Tranche one funding will allow us to substantially increase the innovation management capacity ans support, the number of proof of concept projects to advance fundamental research findings through assessed technology solutions , making them raady for product development and investment with reduced risk. Additionally IKC will support a smaller numbe rof larger scale collaborative R and D programmes. IKC will deliver highly skilled multidisciplinary scientists and engineers to industry, with enhanced innovation skills and experience in medical technology innovation. As a national centre of excelence in regenerative medicine and therapies, IKC will act as centre of excellence for both knowledge, IP, unique capabilites and intellectual assets, supplyin gindustry directly and where appropriate acting o signpost needs to other acadmeic institutions and collaborators. IKC will directly address clinical needs and provide a supportive environment for tripartite academic, clincial and industry interactions. IKC will address broader societal needs through delivery of emergent healthcare technology solutions to the ageing population and will raise the profielof successful science and innovation to society at large.

Publications

10 25 50

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Prokopovich P (2011) Spatial variation of wear on Charité lumbar discs. in Acta biomaterialia

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Sariali E (2012) Spectral characterization of squeaking in ceramic-on-ceramic total hip arthroplasty: comparison of in vitro and in vivo values. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society

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Taylor SD (2012) Comparison of human and animal femoral head chondral properties and geometries. in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

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Wang L (2012) The effect of cup orientation and coverage on contact mechanics and range of motion of metal-on-metal hip resurfacing arthroplasty. in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

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Williams S (2013) Comparison of ceramic-on-metal and metal-on-metal hip prostheses under adverse conditions. in Journal of biomedical materials research. Part B, Applied biomaterials

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Wilshaw SP (2012) Development and characterization of acellular allogeneic arterial matrices. in Tissue engineering. Part A

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Zhou X (2011) The influence of concave dimples on the metallic counterface on the wear of ultra-high molecular weight polyethylene in Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology

 
Description High quality research and innovation platform
£95m new research income
Established academic supply chain and translational capability across 250 researchers
Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners
New Medical Technologies building and a new post of Director of Innovation in Medical Technologies

Successful sustainable innovation
Defined robust sustainability model
Strategically identified and prioritised key market sectors that offer significant opportunity
Developed a culture of innovation across academic, industry and clinical partnerships
Sharing innovation good practice with 9 UK HEIs and other innovation hubs at Leeds
166 collaborative projects, 66 industry co-investors

Established profile and reputation
Robust brand identity and reach across the UK and beyond through targeted marketing and communications
Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK
High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation.
Significant political visits and media coverage

Successful innovation and translation
Established Innovation system, pipeline, stage gates and criteria for progression
Defined IP portfolio and directly funded 42 Proof of Concept and 6 Co-Development projects
Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded
Contributed to the development of 46 new products that have reached the market.
Generated £57m investment in private sector partners for development of our IP/technology and a further £30m plus investment in private sector for development arising out of collaborative projects
Exploitation Route Exploitation and commercialisation by our industry partners
Sectors Healthcare

URL http://www.medical-technologies.co.uk
 
Description High quality research and innovation platform £95m new research income Established academic supply chain and translational capability across 250 researchers Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners New Medical Technologies building and a new post of Director of Innovation in Medical Technologies Successful sustainable innovation Defined robust sustainability model Strategically identified and prioritised key market sectors that offer significant opportunity Developed a culture of innovation across academic, industry and clinical partnerships Sharing innovation good practice with 9 UK HEIs and other innovation hubs at Leeds 166 collaborative projects, 66 industry co-investors Established profile and reputation Robust brand identity and reach across the UK and beyond through targeted marketing and communications Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation. Significant political visits and media coverage Successful innovation and translation Established Innovation system, pipeline, stage gates and criteria for progression Defined IP portfolio and directly funded 42 Proof of Concept and 6 Co-Development projects Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded Contributed to the development of 46 new products that have reached the market. Generated £57m investment in private sector partners for development of our IP/technology and a further £30m plus investment in private sector for development arising out of collaborative projects
First Year Of Impact 2011
Sector Healthcare
Impact Types Societal

 
Description international standards committee chair
Geographic Reach Asia 
Policy Influence Type Membership of a guideline committee
Impact international pre clinical testing standards
 
Description Biocomposites
Amount £200,000 (GBP)
Funding ID LMJ 
Organisation Biocomposites 
Sector Private
Country United Kingdom
Start 01/2013 
End 01/2016
 
Description Biomedical research unit
Amount £6,000,000 (GBP)
Funding ID Leeds musculoskeletal biomedical research unit 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2017
 
Description British Heart Foundation Research Grant
Amount £798,506 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CDT 2014-22
Amount £4,000,000 (GBP)
Funding ID CDT TERM 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2014 
End 09/2022
 
Description Capital equipment CDT
Amount £240,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 11/2015 
End 04/2019
 
Description Capital equipment hip and knee simulators
Amount £920,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2015 
End 04/2020
 
Description Catalyst Medical Technologies
Amount £3,000,000 (GBP)
Organisation Higher Education Funding Council for England 
Sector Public
Country United Kingdom
Start 10/2015 
End 10/2018
 
Description China-UK Researcher Links Workshop on Healthcare Technologies (Dec 6-8th 2016). Sichuan Province, Chengdu, China. Travel fellowship - PI - (Newton Fund via Bradford Uni)
Amount £1,800 (GBP)
Organisation University of Bradford 
Sector Academic/University
Country United Kingdom
Start 12/2016 
End 12/2016
 
Description DTC 208-2017
Amount £7,000,000 (GBP)
Funding ID DTC 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2008 
End 09/2017
 
Description Development of Prototype Device for Minimally Invasive Delivery of Osteospheres for Treatment of Osteoporosis (MIDOs)
Amount £1,100,509 (GBP)
Funding ID II-C3-0714-20001 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2015 
End 01/2018
 
Description EPSRC IAA (Impact Accelerator Account) - EP/K503800/1: Regenerating Bone Tissue in Osteoporotic Patients Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells.
Amount £70,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description EPSRC IAA Feasibility Study Award (Steve Russell - Collagen wound dressing)
Amount £10,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description EPSRC cartilage programme
Amount £4,600,000 (GBP)
Funding ID EPG01121721 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2009 
End 06/2015
 
Description European Research Council advanced award
Amount £2,000,000 (GBP)
Funding ID Proposal 267114 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 04/2011 
End 04/2016
 
Description Industry Biocomposites
Amount £150,000 (GBP)
Organisation Biocomposites 
Sector Private
Country United Kingdom
Start 07/2015 
End 07/2016
 
Description Industry Invibio
Amount £300,000 (GBP)
Organisation Invibio 
Sector Private
Country United Kingdom
Start 10/2015 
End 10/2017
 
Description Mecical technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices
Amount £4,000,000 (GBP)
Funding ID EP/N00941X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2020
 
Description Medcial engineering centre
Amount £160,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2019
 
Description Medical Research Council Confidence in Concept Award (Steve Russell - Collagen wound dressing)
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Medical Technologies IKC Phase 2 Regenerative Devices
Amount £3,000,000 (GBP)
Funding ID EP/N00941X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 06/2020
 
Description Medical engineering centre
Amount £4,200,000 (GBP)
Funding ID WELMEC 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2015
 
Description NHSBT
Amount £200,000 (GBP)
Funding ID EI 
Organisation NHS Blood and Transplant (NHSBT) 
Sector Public
Country United Kingdom
Start 01/2014 
End 01/2017
 
Description NIHR Invention for Innovation (i4i) Programme (Pete Culmer IAP)
Amount £445,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description NIHR related (II-C3-0714-20001 - Development of Prototype Device for minimally invasive delivery of osteospheres for Treatment of Osteoporosis
Amount £1,200,000 (GBP)
Funding ID II-C3-0714-20001 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2015 
End 01/2018
 
Description ORUK studentship: Influencing Stem Cells down an Osteogenic Lineage via Release of Therapeutic Ions from Resorbable Porous Calcium Phosphate Microspheres
Amount £74,000 (GBP)
Organisation Orthopaedic Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Tissue regenix
Amount £60,000 (GBP)
Funding ID EI 
Organisation Tissue Regenix Ltd 
Sector Private
Country United Kingdom
Start 01/2016 
End 01/2018
 
Description invibio
Amount £400,000 (GBP)
Funding ID LMJ 
Organisation Invibio 
Sector Private
Country United Kingdom
Start 01/2014 
End 12/2016
 
Description mathys
Amount £400,000 (GBP)
Funding ID LMJ 
Organisation Mathys 
Sector Private
Country Switzerland
Start 01/2014 
End 01/2016
 
Description senior investigator
Amount £100,000 (GBP)
Funding ID LMBRU 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 04/2015
 
Title Hip Joint simulator 
Description In vitro simulator for artificial hip joints 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Method commercialised by Simulation Solutions 
 
Title Knee joint simulator 
Description artificial knee joint simulator 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Simulator and simulation method commercialised by simulation solution 
 
Title Natural knee simulator 
Description Simulation system for natural knee 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Simulator commercially available, Simulation Solutions 
 
Title POC015 Methods for histological staining of sheep tissue 
Description This relates to new methods, specifically a whole battery of methods to stain sheep tissue were developed that were not available previously. 
Type Of Material Biological samples 
Year Produced 2017 
Provided To Others? No  
Impact New methods developed; whole battery of methods to stain sheep tissue were developed that were not available previously. These methods have been made available to the wider team and subsequent research projects. 
 
Title natural hip simulator 
Description Simulation system for natural hip 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2014 
Provided To Others? Yes  
Impact System commercially availa le from Simulation Solutions 
 
Title spine simulator 
Description Spinal disc simulator 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2012 
Provided To Others? Yes  
Impact Commercialised by Simulation solutions 
 
Title Biomechanical and biotribological simulation model natural hip 
Description Biomechanical and biotribological model of natural hip 
Type Of Material Computer model/algorithm 
Year Produced 2013 
Provided To Others? Yes  
Impact used in follow on research 
 
Title Biomechanical model of functional spinal unit 
Description model of functional spinal unit 
Type Of Material Computer model/algorithm 
Year Produced 2014 
Provided To Others? Yes  
Impact used in follow on research 
 
Title Biotribological model naturala knee 
Description Biotribological model natural knee 
Type Of Material Computer model/algorithm 
Year Produced 2014 
Provided To Others? Yes  
Impact Used in follow on research on regenerative devices 
 
Title wear simulation model artificial hip 
Description wear simulation model artificial hip 
Type Of Material Computer model/algorithm 
Year Produced 2010 
Provided To Others? Yes  
Impact applied in industry contract research 
 
Title wear simulation model artificial knee 
Description wear simulation model artificial knee 
Type Of Material Computer model/algorithm 
Year Produced 2012 
Provided To Others? Yes  
Impact used in industry contract research 
 
Description Avacta 
Organisation Avacta Group
Country United Kingdom 
Sector Private 
PI Contribution Electronic Biomarker Detection (eTect); Use of spectroscopy for non-invasive phenotyping of stem cells; Use of di-electrophoresis for minimally manipulated stem cell enrichment.
Start Year 2010
 
Description Biocomposites Ltd 
Organisation Biocomposites
Country United Kingdom 
Sector Private 
PI Contribution Calcium Phosphate Bone Void Filler - A Pin-on-Plate Study; Calcium Sulphate Bone Void Filler Comparison - A Pin-on-Plate Study
Collaborator Contribution participate in research and publication
Impact Publication
Start Year 2014
 
Description Corin 
Organisation Corin Group PLC
Country United Kingdom 
Sector Private 
PI Contribution Metal on metal hip wear
Collaborator Contribution materials
Impact multidiciplinary
Start Year 2009
 
Description Corline 
Organisation Corline
Country Sweden 
Sector Private 
PI Contribution Heparin coated acellular vascular grafts
Start Year 2011
 
Description Credentis 
Organisation Credentis
Country Switzerland 
Sector Private 
PI Contribution Use of Self assembling peptide(SAP) technology for hard tissue engineering (dental applications)
Collaborator Contribution materilas
Impact Ip piublications
Start Year 2014
 
Description DePuy 
Organisation Depuy International
Country United Kingdom 
Sector Private 
PI Contribution Thirty-three projects.
Collaborator Contribution funds , materilas staff
Impact publications
Start Year 2013
 
Description Depuy International Ltd 
Organisation Depuy International
Country United Kingdom 
Sector Private 
Start Year 2003
 
Description Invibio 
Organisation Invibio
Country United Kingdom 
Sector Private 
PI Contribution Four projects: PEEK low con knees; Investigation of biocompatibilty of PEEK wear debris; Investigation of PEEK as cervical disc bearing material; Low Cost Polymer Knee
Start Year 2010
 
Description JRI 
Organisation JRI Orthapaedics
Country United Kingdom 
Sector Private 
PI Contribution Ceramic composite hip wear
Start Year 2009
 
Description Mathys Medical 
Organisation Mathys
Country Switzerland 
Sector Private 
PI Contribution Four projects including: Evaluation of potential ceramic matrix hips Ceramic matrix composite hip Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys IV) Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys V)
Collaborator Contribution materials , research methods , analysis
Impact papres
Start Year 2013
 
Description NAMSA 
Organisation North American Science Associates Inc
Country United States 
Sector Private 
PI Contribution In vivo testing of dCell bone to detremine osseointegration and biocompatibility
Collaborator Contribution undertaking research work
Impact pubication
Start Year 2015
 
Description NHS NBTS 
Organisation NHS Blood and Transplant (NHSBT)
Department National Blood Service
Country United Kingdom 
Sector Public 
PI Contribution 8 projects in collaboration with NHS NBTS Acellular bone ligament graft (Human) Acellular bone meniscus bone graft (Human) Acellular OC graft (Human) Allo vascular graft Allo heart valve Biocompatibility of acellular allogeanic dermis Acellular allogeneic aorta Development of dCELL bone-patella-bone allograft for anterior cruciate ligament replacement
Collaborator Contribution funds time
Impact multidiciplinary
Start Year 2010
 
Description National Blood Service 
Organisation NHS Blood and Transplant (NHSBT)
Department National Blood Service
Country United Kingdom 
Sector Public 
Start Year 2003
 
Description Neotherix 
Organisation Neotherix Ltd
Country United Kingdom 
Sector Private 
PI Contribution Repair of oral and peridontal defects using regenerative and antibacterial strategies delivered by a novel tissue scaffold vehicle Polymeric scaffolds functionalised for periodontal repair
Collaborator Contribution materials
Impact multidisciplinary
Start Year 2015
 
Description Neu Biomechanics, BiteCiC 
Organisation Neu Biomechanics
Country United Kingdom 
Sector Private 
PI Contribution Evaluation of coating wear
Start Year 2010
 
Description Simpleware 
Organisation Simpleware Ltd
Country United Kingdom 
Sector Private 
PI Contribution Development of finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort
Collaborator Contribution software
Impact papers
Start Year 2014
 
Description Simulation Solutions 
Organisation Simulation Solutions
Country United Kingdom 
Sector Private 
PI Contribution 10 projects in collaboration with Simulation Solutions: High flex knee simulator Natural knee simulator Natural hip simulator Natural spine simulator Natural joint friction simulator knee joint simulator SOP for hip simulator SOP for knee simulator Natural Knee Simulation System Electro mechanical hip simulator method SOP and training
Collaborator Contribution equipment development
Impact publications
Start Year 2014
 
Description Surgical Innovations 
Organisation Surgical Innovations
Country United Kingdom 
Sector Private 
PI Contribution A total of 4 collaborations with Surgical Innovations A new Arthroscopic Port for use in Arthroscopic Surgery applications Arthroscopic Port Environment Test Cell Design improvements to existing laparoscopy scissors Intra-Abdominal Platform (IAP) development
Start Year 2010
 
Description Tissue Regenix 
Organisation Tissue Regenix Ltd
Country United Kingdom 
Sector Private 
PI Contribution A total of 12 projects collaborating with Tissue Regenix Acellular ligament graft (Animal) Acellular bone meniscus bone graft (Animal) Acellular OC graft (Animal) Xeno vascular patch Xeno heart valve Decellularised bladder Decellularised meniscus (see also 12b) Acellular porcine flexor tendon graft Development of the dCELL Partial Meniscus In vivo testing of dCell bone to determine osseointegration and biocompatibility In vivo evaluation of decellularised porcine pulmonary roots. Long Term Evaluation of an Acellular Bovine Arterial Graft in an Ovine Arteriovenous Access Model
Start Year 2009
 
Description Vascutec 
Organisation Vascutek Ltd
Country United Kingdom 
Sector Private 
PI Contribution Heart valve conduit
Start Year 2010
 
Title Acellular Vascular Products 
Description A product comprising a natural acellular xenogenic vascular tissue matrix having at least an80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery. 
IP Reference WO2012042250 
Protection Patent application published
Year Protection Granted 2012
Licensed Yes
Impact This IP has been assigned to Tissue Regenix (AIM listed Leeds spin out company), which is developing a portfolio of products based on this IP as well as three other patents we have assigned. Products such as a vascular patch for peripheral vascular reconstruction (clinical trial in 2009).
 
Title Acellular Vascular Products 
Description Method for producing acellular arteries 
IP Reference WO2002096476 
Protection Patent granted
Year Protection Granted 2011
Licensed Yes
Impact Now under commercial development by Tissue Regenix group PLC Also under development by NHS Blood & Transplant Tissue Services for application to allogeneic donor arteries
 
Title Acellular porcine meniscus for meniscal repair/replacement 
Description The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised. 
IP Reference WO2008059244 
Protection Patent granted
Year Protection Granted 2009
Licensed Yes
Impact This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix.
 
Title Beta Sheet Tape Ribbons in Tissue Engineering 
Description There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a ß-sheet tape-like substructure. 
IP Reference WO2004007532 
Protection Patent granted
Year Protection Granted 2009
Licensed Yes
Impact A spin-out company (Credentis AG).
 
Title Combination of material for joint prosthesis 
Description An orthopaedic joint prosthesis comprises first and second articulating components having respective bearing surfaces in contact with one another. The material of the first bearing surface (14) comprises a metallic material and the material of the second bearing surface (6) comprises a ceramic material. The hardness of the metallic material is at least about 2500 MPa, and the hardness of the ceramic material is greater than that of the metallic material by at least about 4000 MPa. 
IP Reference WO2001017464 
Protection Patent granted
Year Protection Granted 2006
Licensed Yes
Impact Clinical trials started 2006. Now marketed world wide. FDA IDE study underway in USA. A revenue sharing arrangement is in place between us and DePuy International.
 
Title Composite connective Tissue and Bone Implants 
Description Method for the decellularisation of bone-meniscus-bone; bone-tendon-bone and bone-cartilage 
IP Reference WO2014037713 
Protection Patent application published
Year Protection Granted 2013
Licensed No
Impact Proof of concept phase in large animal model completed for bone-tendon-bone, discussions ongoing with a company on development re licensing
 
Title Composition 
Description The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth. 
IP Reference WO2012046082 
Protection Patent application published
Year Protection Granted 2012
Licensed Yes
Impact This IP is supporting three projects: an EPSRC Health Technology Challenge project, an Innovate UK project, and a European funded Marie-Curie award with industrial partners which aims to produce commercial products. IPGroup and commercialisation team scoping out POC in vivo trial to evaluate the technology with the possibility of forming a spin-out company, two other patents would also be bought into this project.
 
Title Decellularised human livers 
Description The process could be applied to human donor organs thus increasing the number of such organs available for transplantation. This IP has not been patented and may still be confidential. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2014
Licensed No
Impact Too early for notable impacts.
 
Title Low concentration SDS and Protease inhibitors for decellularisation 
Description A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors. 
IP Reference WO2002096476 
Protection Patent granted
Year Protection Granted 2007
Licensed Yes
Impact A portfolio of products is in development for different clinical needs. A spin-out company has been formed (Tissue Regenix) which has a licence of this and three other patents. Also, this IP has been licensed to NHS Blood and Transplant, Tissue Services, for allografts in the NHS in the UK.
 
Title METHOD AND APPARATUS FOR MANIPULATING PARTICLES 
Description A method and apparatus for manipulating polarizable dielectric particles. The method includes positioning a liquid containing the particles above a surface of a piezoelectric material (2). The method also includes inducing a shear-horizontal surface acoustic wave in the piezoelectric material (2), thereby to form a time-varying non-uniform evanescent electric field extending into the liquid. The method further includes using the time-varying non-uniform evanescent electric field to apply a force to at least some of the particles (50, 52) by dielectrophoresis. 
IP Reference WO2015022481 
Protection Patent application published
Year Protection Granted 2015
Licensed Yes
Impact Spin out of company based on this technology called Relitect.
 
Title Magnetometer for medical use 
Description A medical magnetometer (10) comprising one or more induction coils (2) for detecting a time varying magnetic field of a region of a subject's body, such as the heart. Each coil has a maximum outer diameter of 4 to 7 cm, and a configuration such that the ratio of the coil's length to its outer diameter is at least 0.5, and the ratio of the coil's inner diameter to its outer diameter is 0.5 or less. Each induction coil (2) is coupled to a respective detection circuit comprising a low impedance pre-ampiifier (3), a low pass filter (5), a notch filter (6) to remove line noise, and an averaging element (7). Each detection circuit produces an output signal (9) for use to analyse the time varying magnetic field of the region of the subject's body. 
IP Reference WO2014006387 
Protection Patent application published
Year Protection Granted 2014
Licensed Yes
Impact IP is currently licensed to a Leeds spin-out (Creavo Medical Technologies Ltd, previously known as Quantum Imaging Ltd). Primary focus at present is the development of cardiac focussed devices, such as the VitalScan machine to support rule out triaging of patients presenting with chest pain in an emergency room setting.
 
Title Method and apparatus for manipulating particles (DEP-SAW) 
Description This invention relates to a method and apparatus for manipulating particles. The patent has not been published yet so may still be confidential. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2013
Licensed No
Impact The manipulation of particles finds application in a wide range of fields, many of which are medical in nature.
 
Title Methods and devices for detecting structural changes in a molecule measuring electrochemical impedance 
Description The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays. 
IP Reference WO2008032066 
Protection Patent application published
Year Protection Granted 2008
Licensed No
Impact This IP should support a spin-out company (Phase DX) in the near future.
 
Title ORTHOPAEDIC MEDICAL DEVICE 
Description This present invention provides an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site or an injury site. The invention includes methods of increasing a cell population at a surgical site or injury, a method of improving surgical outcome of synovial joint procedures and methods of delivering intra-operative minimally manipulated cells to a synovial joint. 
IP Reference US2018161022 
Protection Patent application published
Year Protection Granted 2018
Licensed Yes
Impact Xiros have an exclusive license to use and sell, in all species but University still are able to use technology for research and teaching.
 
Title On-chip spectroscopy system 
Description This IP has not been patented and may still be confidential. 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No notable impacts as yet.
 
Title Orthopaedic medical device 
Description A UK priority patent filing has been made but not yet published. The invention relates to an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2014
Licensed No
Impact A first in man clinical trial is being planned.
 
Title POROUS AND NON-POROUS BODIES 
Description A method of manufacture of a powder comprising, or consisting essentially of, microspheres, the method comprising: providing a feed powder; and applying at least one spheroidisation flame to the powder. The powder may be suitable for use in medical and/or non-medical applications. 
IP Reference WO2016027110 
Protection Patent granted
Year Protection Granted 2016
Licensed Yes
Impact Unknown as yet (12/03/2019)
 
Title Porcine bladder biomaterial 
Description The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro. 
IP Reference WO2007110634 
Protection Patent granted
Year Protection Granted 2007
Licensed Yes
Impact This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix to date.
 
Title Regional anaesthetic delivery system 
Description Unpatented know-how on a regional anaesthetic delivery system. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2013
Licensed No
Impact Confidentiality agreements in place with various potential partners but no notable impacts yet.
 
Title SURGICAL RETRACTION DEVICE AND PROCEDURE 
Description The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length. 
IP Reference WO2017134415 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact None yet, commercial device undergoing prototyping. Patent arose based on refinements made during i4i project, continuing work performed during IKC POC project.
 
Title Scaffold proteins derived from plant cystatins 
Description The present invention relates to scaffold proteins derived from plant cystatins and to nucleic acids encoding them. The scaffolds are highly stable and have the ability to display peptides. The scaffolds are particularly well suited for constructing libraries, e.g. in phage display or related systems. The invention also related to various uses of the scaffolds, including in therapy, diagnosis, environmental and security monitoring, synthetic biology and research, and to cells and cell cultures expressing the scaffold proteins. 
IP Reference WO2014125290 
Protection Patent application published
Year Protection Granted 2014
Licensed Yes
Impact This IP was exclusively licensed to Avacta Life Sciences Ltd in the field of life sciences research reagents and diagnostics. Avacta pay royalties based on the University providing a screening service to Avacta and also for catalogue sales.
 
Title Surgical Retraction Device and Procedure 
Description The invention provides a retraction device (1) adapted for use in minimally invasive surgery, said device comprising: (a) access means ( 3 ); (b) rigid support means; (c) expandable retraction means (2) comprising a multiplicity of radially oriented members (10); (d) flexible attachment means (6); and (e) a multiplicity of magnetic means, wherein said expandable retraction means in its non- expanded form is attached to said rigid support means by said flexible attachment means and is insertable into a subject through said access means, and wherein said multiplicity of magnetic means are comprised in said expandable retraction means. The invention also provides expandable retraction means comprising a multiplicity of radially oriented members and a method for the use of a retraction device in minimally invasive surgery, the method comprising the steps of providing a retraction device according to the first aspect of the invention, inserting said expandable retraction means via said access means through the cavity wall of a subject, deploying the expandable retraction means in its expanded form, magnetising the tissue to be retracted and attaching the magnetised tissue to the retraction device. The device and method according to the invention satisfy the necessary criteria for use in MIS applications and provide for ease in both manufacture and use, and potential application in many areas of MIS. 
IP Reference WO2017134415 
Protection Patent application published
Year Protection Granted 2012
Licensed No
Impact Two companies are potentially interested in using this IP.
 
Title Tissue sensors for medical diagnosis 
Description Optical sensors for the diagnosis of a range of medical conditions. 
IP Reference  
Protection Protection not required
Year Protection Granted 2012
Licensed No
Impact A licence, with revenue sharing provisions, with another University.
 
Title Ultrasonic modification of soft tissue matrices 
Description The present invention provides a method of, and apparatus for, utilising ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularised in continuous form. The present invention also provides for the production of tissue matrices with improved recellularisation properties, cell stratification or patterning. 
IP Reference WO2004103461 
Protection Patent granted
Year Protection Granted 2007
Licensed Yes
Impact This IP is used in various of our Proof of Concept projects. It has also supported a spin-out company, and a portfolio of products is under development by them.
 
Title Virtual Microscopy 
Description Computer implemented methods and data processing apparatus are described for displaying virtual slide images. Images of a plurality of slides are automatically displayed in a first region of a display device at a first magnification. The slides comprise all the slides including material from a same specimen. An image of at least one of the slides is displayed in a second region at a second magnification greater than the first magnification. At least the image displayed in the second region is changed responsive to receiving user input. Methods for automatically determining a slide layout pattern and methods for virtually melding glass slide images into a single image are also described. 
IP Reference US8970618 
Protection Patent application published
Year Protection Granted 2011
Licensed No
Impact IP portfolio assigned to Roche (Ventana Medical Systems) as part of asset sale of technology, deal completed July 2015. EP and GB patents still pending. US patent granted.
 
Title Visual parameter optimisation software 
Description Software and an algorithm for use with image analysis/process engineering. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2013
Licensed No
Impact This software was developed for the optimization of image processing algorithms. Today, this is done in a time-consuming way that relies on trial-and-error. Our software enables users to make better choices of parameter values, to do so faster, and to better understand the influence of the parameters on image processing. The software is applicable to image processing, in general, although our research has focussed on applications in biomedical research.
 
Title Arthroscopic device for stimulating synovial mesenchymal stem cells in the knee 
Description The arthroscopic device is currently (as of Jan 2017) in a small scale clinical evaluation study at Leeds Teaching Hospitals funded through NIHR funded Leeds Musculoskeletal Biomedical Research Unit, led and managed by Prof Dennis McGonagle, Dr Tom Baboolal with Consultant Mr Owen Wall. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact IKC funded Proof of Concept (POC) Project supported early development of the new medical device. This supported device design and testing, prototype manufacture and subsequent manufacture of devices for use in the clinical evaluation. The POC also supported generation of data used in patent filing. 
 
Title ISO accredited simulation test laboratory 
Description ISO accredited simulation test laboratory for pre clinical testing and trials widely used by customers around globe 
Type Support Tool - For Medical Intervention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2013
Development Status Under active development/distribution
Impact uptake by wide range of companies 
 
Title acellular bone 
Description under development and in in vivo trials 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under development and in animal trials 
 
Title acellular bone cartilage osteochondral graft 
Description under development 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under developemnt 
 
Title acellular bone cartilage osteochondral graft 
Description under development NHSBT 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact under development 
 
Title acellular bone patellar bone graft 
Description under development by NHSBT 
Type Therapeutic Intervention - Surgery
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under development by NHSBT 
 
Title acellular dcell vascular patch 
Description licensed to and commercialised by Tissue Regenix 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Clinical Trial? Yes
Impact First dcell clinical product 
URL https://clinicaltrials.gov/show/NCT00958230
 
Title acellular dcell dermis 
Description commercialised by Tissue regenix from 2014 
Type Therapeutic Intervention - Medical Devices
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact sold and distributed in USA 
 
Title acellular dermis 
Description supplied as clinical product by NHSBT 
Type Therapeutic Intervention - Surgery
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact supplied by NHSBT, improved wound healing in chronic leg ulcers 
 
Title acellular heart valve 
Description clinical application through human tissue bank 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact proof of clinical use acellular technology 
 
Title acellular vascular graft 
Description under development by NHSBT and Tissue Regenix 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact Under development by NHSBT an dTissue Regenix 
 
Title all polymer knee 
Description collaborative development with Invibio 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact collaborative development with Invibio 
 
Title ceramic on ceramic hip 
Description Mathys 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Market authorisation
Year Development Stage Completed 2012
Development Status Under active development/distribution
Impact successfully adopted an d commercilised 
 
Title ceramic on ceramic and ceramic on metal hip 
Description commercialised by DePuy and by Mathys 
Type Therapeutic Intervention - Medical Devices
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact successfully adopted an d commercilised 
 
Title dcell ligament 
Description Under commercial development by tissue Regenix, progressing to CE mark and product launch 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact under commercial development by Tissue Regenix in clinical trial started 2015 proceeding to Ce mark and product launch 2017 
URL https://clinicaltrials.gov/show/NCT02540811
 
Title dcell meniscus 
Description Developed by tissue Regenix In clinical trial started 2015 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact first in man clinical trial started 2015 
URL https://clinicaltrials.gov/show/NCT02270905
 
Title ankle joint simulator 
Description ankle joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2015 
Impact support product development 
 
Title finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort 
Description This project has been led by Dr Ruth Wilcox in partnership with Simpleware Limited. The development of the software add-on has been completed and the final validations with the Leeds data set-set are coming to an end. It is anticipated that a technology demonstrator project will now be undertaken with a company that can demonstrate the utility of the software for evaluating spinal implants. The commercial team is now engaged and discussions with Simpleware around a possible license deal are on-going. It is envisaged that as part of this license deal Simpleware will engage Leeds expertise as part of their offer to companies. In addition Leeds personnel will retain the right to undertake consultancy in their own capacity. 
Type Of Technology Software 
Year Produced 2013 
Impact further research 
 
Title hip joint simulator 
Description hip joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2012 
Impact commercial product Simulation solutions 
 
Title knee joint simulator 
Description knee joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2013 
Impact Commercial product simulation solutions 
 
Title natural hip simulator 
Description natural hip simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2014 
Impact commercial product simulation solutions 
 
Title natural knee simulator 
Description natural knee simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2013 
Impact commercialised by simulation solutions 
 
Title spinal disc simulator 
Description spinal disc simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2010 
Impact commercial product simulation solutions 
 
Company Name Creavo Medical Technologies Ltd (formerly Quantum Imaging) 
Description Creavo Medical Technologies Ltd is a UK-based, privately held medical device company engaged in the development of innovative imaging technologies. The company was formed to commercialise sensor technology developed by Professor Ben Varcoe, Chair of Quantum Information Science at Leeds University and has facilities in Leeds and in Warwickshire UK. The first application of this technology will be to aid the rapid triage and identification of patients presenting to Emergency Departments with chest pain, but who ultimately have no cardiac related diagnosis. Identifying these patients early enables them to leave expensive cardiac diagnostic pathways so releasing resources to focus on other acute patients. Creavo Medical Technologies has an experienced management team, with a mix of fundamental research, medical device commercialisation, manufacturing and global regulatory and clinical strategy. 
Year Established 2014 
Impact A new cardiac scanning device that could save the NHS £200 million a year is being trialled at four of the UK's largest emergency departments (Bristol, Nottingham, Leicester and Sheffield). The British-made Vitalscan device, which has been developed by Creavo Medical Technologies and could revolutionise the way patients with chest pain are managed in emergency departments, works by conducting a non-invasive three to five-minute scan at a patient's bedside to rule out significant cardiac conditions, such as heart attacks. Data from the York Health Economics Consortium shows that 1.3 million A&E admissions in 2014/15 were due to chest pain. Of these, 63% ultimately had no cardiac-related condition but, the majority would still have gone through the same costly cardiac triage process of someone having a heart attack. Vitalscan has the potential to identify a significant proportion of these patients which would radically change the management of chest pain patients entering emergency departments. Conservative estimates indicate that the device could save the NHS £200 million a year, the equivalent of £3.85 million a week and £382 a minute, easing pressure on bed space in A&E departments and reducing patient anxiety by getting patients to the correct treatment more quickly. Steve Parker, CEO Creavo Medical Technologies says: "Cardiac-related chest pain is one of the biggest issues facing emergency departments in the western world due to the economic burden it places on healthcare services and the disruption it causes to inpatient care. "The triage process for someone entering an emergency department with chest pain can take anywhere from six to 24 hours which places a huge amount of strain on resources. "Early results from smaller sets of clinical trials indicate that Vitalscan can quickly identify and rule out significant ischemic heart disease so it prevents patients who aren't suffering from a cardiac-related condition from having to go through the lengthy, costly chest pain triage process, easing the burden on emergency departments at a time when they are facing unprecedented pressures." Creavo Medical Technologies was established to commercialise the work undertaken by Professor Ben Varcoe at the University of Leeds to develop Vitalscan, a portable, passive magnetocardiography device that measures the electromagnetic fluctuations of the heart, while maintaining the accuracy and efficacy of older SQUID devices. The start of clinical trials at Sheffield Teaching Hospitals NHS Foundation Trust, University Hospitals of Leicester NHS Trust, North Bristol NHS Trust and Nottingham University Hospitals NHS Trust marks the largest ever clinical trial of a magnetocardiography device. This will be followed by a second stage starting at three centres in the United States at Mayo Clinic Rochester, Cincinnati and Baylor Texas.
Website http://creavomedtech.com/
 
Company Name Tissue Regenix 
Description Developemnt and manufacture of Regenerative Biological Scaffolds for tissue repair in vascular, cardiovascular and musculoskeletal systems 
Year Established 2007 
Impact aim listed d raised £0m investment value £150m 4 clinical products
 
Company Name Relitect Ltd 
Description Relitect Ltd are developing a novel technology for the detection of binding events, which can be used for the analysis of proteins, small molecules and nucleic acids. The Relitect proprietary technology enables highly sensitive detection of biomarkers or other analytes in a label free multiplexed format, using small sample volumes. Relitect's approach has potential for utilisation across the clinical diagnostics and life sciences industries. 
Year Established 2014 
Impact March 2015 - Relitect secured a £750K tranched investment from IP Group Plc and Scottish Enterprise's investment arm, the Scottish Investment Bank to develop its novel high sensitivity diagnostic/science technology. 20th April 2015 - Relitect moves to new laboratory facilities at Biocity Scotland -www.biocity.co.uk/biocity/scotland
Website http://www.relitect.com/
 
Description Bone paste could provide treatment for osteoporosis 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article in Orthopaedic Product News profiling the research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells.
Year(s) Of Engagement Activity 2015
URL http://www.opnews.com/2015/02/osteoporosis/9449
 
Description Funding for Injectable Stem-Cell Carrying Microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://scienmag.com/1-2-million-for-injectable-stem-cell-carrying-microspheres-to-regenerate-bones/
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://abccontentboard.com/breakthrough-stem-call-jab-could-save-millions-from-osteoporosis-bone-fra...
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL https://www.m3medical.com/news/blog/2016/07/26/microsphere-plan-for-bone-care/
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://medicalphysicsweb.org/cws/article/newsfeed/65702
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://healthmedicinet.com/i/1-2-million-for-injectable-stem-cell-carrying-microspheres-to-regenerat...
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL https://phys.org/wire-news/230900690/12-million-for-injectable-stem-cell-carrying-microspheres-to-re...
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL https://www.myscience.org/wire/1_2m_for_injectable_stem_cell_carrying_microspheres_to_regenerate_bon...
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://www.englemed.co.uk/16/16jul261_osteoporosis_treatment.php
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://www.hcplive.com/medical-news/injection-for-injectable-research-midos-project-receives-grant-f...
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL https://www.eurekalert.org/pub_releases/2016-07/uon-fi072516.php
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Blog about general bone research, highlighting IKC POC025 as a case study
Year(s) Of Engagement Activity 2016
URL http://www.frogheart.ca/?p=21311
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL https://www.m3medical.com/news/blog/2016/07/26/microsphere-plan-for-bone-care/
 
Description Funding for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://microscopy83.rssing.com/chan-6837248/latest.php
 
Description Microspheres as a Treatment for Weak Bones 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Blog about the use of microspheres, highlighting IKC POC025 as a case study
Year(s) Of Engagement Activity 2016
URL https://blog.spotchemi.com/microspheres-as-a-treatment-for-weak-bones/
 
Description National newspaper article - Liquid bone jab may prevent breaks in elderly 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Article in Sunday Times profiling the research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells.
Year(s) Of Engagement Activity 2014
URL https://www.thetimes.co.uk/article/liquid-bone-jab-may-prevent-breaks-in-elderly-nntb3hgc7mg
 
Description National newspaper article: Stem Cell Jab hope to Prevent bone fractures. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Article in Sunday Express profiling the research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells.
Year(s) Of Engagement Activity 2016
URL https://www.express.co.uk/life-style/health/694981/osteoporosis-bone-fracture-stem-cell-injection-tr...
 
Description New grant for injectable stem-cell carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL http://www.nanowerk.com/nanotechnology-news/newsid=44022.php
 
Description Online article - Injectable-stem-cell-carrying-microspheres-to-regenerate-bones 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR.
Year(s) Of Engagement Activity 2016
URL https://www.odtmag.com/contents/view_breaking-news/2016-07-25/injectable-stem-cell-carrying-microsph...
 
Description Press release - funding for injectable stem cell-carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact NIHR article detailing a funding award for the technology
Year(s) Of Engagement Activity 2016
URL http://www.nihr.ac.uk/newsroom/nihr-i4i-challenge-award-for-preventative-osteoporosis-treatment/3796
 
Description Press release - funding for injectable stem cell-carrying microspheres 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Article detailing NIHR funding for the technology.
Year(s) Of Engagement Activity 2016
URL https://www.nottingham.ac.uk/news/pressreleases/2016/july/1.2m-for-injectable-stem-cell-carrying-mic...
 
Description Regen - Regener8 Annual Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Glossy review of annual activity of the Regener8 programme. Review sponsored by the MTIKC
Year(s) Of Engagement Activity 2014,2015,2016