Extending fluorinase [C-18F]-bond biocatalysis for Positron Emission Tomography (PET)
Lead Research Organisation:
University of Aberdeen
Department Name: School of Medical Sciences
Abstract
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People |
ORCID iD |
| Matteo Zanda (Principal Investigator) |
Publications
Dall'Angelo S
(2013)
Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[¹8F]fluoro-5-deoxyribose as a novel tracer.
in Nuclear medicine and biology
Li XG
(2012)
[18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging.
in Chemical communications (Cambridge, England)
Lowe PT
(2019)
Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA).
in Organic & biomolecular chemistry
Musolino M
(2021)
Synthesis, Radiosynthesis, and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [ 18 F]FDR
in European Journal of Organic Chemistry
| Description | We developed a new methodology for incorporating the isotope 18F-fluorine into ddiagnostics for PET imaging |
| Exploitation Route | By translating the radiochemistry methodology to preclinical PET imaging and expanding its scope to new classes of molecules (proteins) |
| Sectors | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | EPSRC grant |
| Amount | £90,000 (GBP) |
| Funding ID | EP/M012573/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 02/2018 |
| Title | FDR as PET tracer |
| Description | We developed a new radiofluorinated tracer for PET Imaging (18F-FDR) which can also be used a a prosthetic group for the radiolfuorination of peptides and biopolymers (antibodies, proteins, etc) |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | FDR has the potential to become an alternative to "click" chemistry technologies for PET radiolabelling of peptides and biopolymers |
| Description | Collaboration with Prof. David O'Hagan |
| Organisation | University of St Andrews |
| Department | School of Chemistry St Andrews |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PET radiochemistry, tracer design and Imaging using fluorinase enzyme and Fluoro-deoxy-ribose |
| Collaborator Contribution | Chemistry and tracer design with fluorinase enzyme |
| Impact | Publications and a second EPSRC grant (starting March 2015) |
| Start Year | 2009 |