Innovation and Knowledge Centre Regenerative Therapies and Devices Tranche 2 IKC RTD

Lead Research Organisation: University of Leeds
Department Name: Mechanical Engineering

Abstract

The Innovation and Knowledge Centre in Regenerative Therapies and Devices has established a sustainable platform to address the creation of new technologies in Regenerative Therapies and Devices. Through strategic prioritisation and development of key technology areas we have sought to promote their accelerated adoption, with increased reliability, within a complex global marketplace with increasing cost constraints. Therapies and devices which facilitate the regeneration of body tissues offer the potential to revolutionise healthcare and be a catalyst for economic growth, creating a new business sector within healthcare technology.

The IKCRTD has built upon the culture and research landscape of the University and its partners (industry, NHS and intermediaries/users) through the development of new innovation infrastructure and practices which deliver major clinical, health and industry outcomes.
In the first two years of operation IKCRTD has:
Established a high quality research and innovation platform that is underpinned by:
£85m new research income
Established academic supply chain, new research centre with 250 researchers
University investment for a new Medical Technologies Innovation building to create a community to stimulate innovation.

Embedded successful sustainable innovation through:
The development of a robust sustainability model
Strategic identification and prioritisation of key market sectors
Contributing to the development of 35 new products that have reached the market
Developing a culture of innovation across academic, industry and clinical partnerships.

Established a significant profile and reputation through:
Significant political visits and media coverage
Widened reach and connections across the UK through strategic alignment with Regener8
Established a Medical Technologies brand to facilitate companies, academics and clinical partners to collaborate with the centre.

Established robust innovation management through:
Recruited and established core team and set up governance structures
Established an innovation pipeline, stage gates and the criteria for project progression
A defined IP portfolio, 11 Proof of Concept and 4 Co-Development projects directly funded
Pipeline of 107 collaborative innovation projects
Engagement with 34 company partners
Access to wider network of 200 plus potential collaborative companies.

Planned Impact

IKCRTD is developing and delivering innovation from fundamental research in regenerative therapies and devices and in broader aspects of medical technologies.

We are currently providing knowledge, unique capabilities and intellectual assts to 34 companies through 107 collaborative projects, 22 of these companies are new collaborators since the start of the IKC. Tranche two funding will allow us to substantially increase the innovation management capacity and support, the number of proof of concept projects to advance fundamental research findings through assessed technology solutions, making them ready for product development and investment with reduced risk. Additionally IKCRTD will support a further two larger scale Co-Development projects in partnership with companies.

IKCRTD is delivering highly skilled multidisciplinary scientists and engineers to industry, with enhanced innovation skills and experience in medical technologies innovation.

As a national centre of excellence in regenerative medicine and therapies, IKCRTD is providing a centre of excellence providing the country with access to knowledge, IP, unique capabilities and intellectual assets, supplying industry directly and where appropriate acting to signpost needs to other academic institutions and collaborators.

IKCRTD is directly addressing and identifying clinical needs and providing a supportive environment for tripartite academic, clinical and industry interactions to support the successful development of new medical and regenerative technologies.

IKCRTD will address broader societal needs through the delivery of emergent healthcare technology solutions to the ageing population and will raise the profile of successful science and innovation to society at large.

Publications

10 25 50

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Bayon Y (2015) Progressing innovation in biomaterials. From the bench to the bed of patients. in Journal of materials science. Materials in medicine

 
Description High quality research and innovation platform
£100m new research income
Established academic supply chain and translational capability across 250 researchers
Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners
New Medical Technologies building and a new post of Director of Innovation in Medical Technologies

Successful sustainable innovation , re-funded until 2020 through phase 2
Defined robust sustainability model
Strategically identified and prioritised key market sectors that offer significant opportunity
Developed a culture of innovation across academic, industry and clinical partnerships
Sharing innovation good practice with 10 UK HEIs and other innovation hubs at Leeds
166 collaborative projects, 66 industry co-investors

Established profile and reputation
Robust brand identity and reach across the UK and beyond through targeted marketing and communications
Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK
High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation.
Significant political visits and media coverage

Successful innovation and translation
Established Innovation system, pipeline, stage gates and criteria for progression
Defined IP portfolio and directly funded 50 Proof of Concept projects
Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded
Contributed to the development of 75 new products services .
Generated £107m investment in private sector partners for development of our IP/technology
Exploitation Route Exploitation and commercialisation by our industry partners and NHS

1, New simulation methods, new equipment and new standards for pre clinical evaluation of joint replacements industry partner Simulation Solutions

2, New and improved, longer lasting joint replacements , industry partners DePuy Synthes, Invibio, Mathys

3, New acellular scaffolds for tissue regeneration
Applications , wound care, ligament repair and replacement, heart valve replacement, industry partner Tissue Regenix

4, New acellular scaffolds for tissue regeneration with grafts derived from human tissue
Applications wound care and heart valve repair, partner NHS Blood and Transplant
Sectors Healthcare

URL http://www.medical-technologies.co.uk
 
Description High quality research and innovation platform £95m new research income Established academic supply chain and translational capability across 250 researchers Active collaborations and technology validation with 10 UK HEIs, 18 academic and clinical partners New Medical Technologies building and a new post of Director of Innovation in Medical Technologies Successful sustainable innovation system renewed to 2020 Strategically identified and prioritised key market sectors that offer significant opportunity for growth estimated as $1bn by 2020 Developed a culture of innovation across academic, industry and clinical partnerships Sharing innovation good practice with 10 other UK HEIs and other innovation hubs at Leeds 166 collaborative projects, 66 industry co-investors, 50 proof of concept projects Established profile and reputation Robust brand identity and reach across the UK and beyond through targeted marketing and communications Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation. Significant political visits and media coverage Successful innovation and translation Established Innovation system, pipeline, stage gates and criteria for progression Defined IP portfolio and directly funded 50 Proof of Concept Pipeline of 166 collaborative innovation projects with industry, of which 50 directly IKC funded Contributed to the development of 75 new products or services with uptake by external partners Generated £107m investment in private sector partners in he private sector for development of our IP/technology and collaborative projects Examples and case studies of impact 1, New simulation methods, new equipment and new standards for pre clinical evaluation of joint replacements industry partner Simulation Solutions. Newly developed equipment sold in UK Europe Asia and USA 2, New and improved, longer lasting joint replacements , industry partners DePuy Synthes, Invibio, Mathys, sold in Uk, Europe, USA and world wide 3, New acellular scaffolds for tissue regeneration Applications , wound care, ligament repair and replacement, heart valve replacement, industry partner University spin out Tissue Regenix Multiple products manufactured and sold in UK, USA and in Europe 4, New acellular scaffolds for tissue regeneration with grafts derived from human tissue Applications wound care and heart valve repair, partner NHS Blood and Transplant, in clinical use in Uk 5, Novel peptide based dental biomaterials for tooth repair filing without drilling , Start up Credentis, multiple commercial products in use across Europe
First Year Of Impact 2011
Sector Healthcare
Impact Types Societal,Economic

 
Description Chair of ISO TC150/SC4 Bone and Joint Replacements
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact New international standards published, including a test method developed at the University of Leeds (ISO14242-4).
 
Description Presented 'provocation' and participated in Wellcome Health Exchange - Wellcome Trust discussion on healthy aging research chaired by Eliza Manningham-Buller (Ruth Wilcox)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Provided evidence and represented RAEng at Royal College of Surgeons Commission on the Future of Surgery (Ruth Wilcox)
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://futureofsurgery.rcseng.ac.uk/?_ga=2.204377936.1302407628.1552062378-663961335.1547802634
 
Description international standards committee chair
Geographic Reach Asia 
Policy Influence Type Membership of a guideline committee
Impact international pre clinical testing standards
 
Description Biocomposites
Amount £200,000 (GBP)
Funding ID LMJ 
Organisation Biocomposites 
Sector Private
Country United Kingdom
Start 01/2013 
End 01/2016
 
Description Biomedical research unit
Amount £6,000,000 (GBP)
Funding ID Leeds musculoskeletal biomedical research unit 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2017
 
Description British Heart Foundation Research Grant
Amount £798,506 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CCTMIH Manufacture of Future Fibrous Products Research Fellowship
Amount £250,000 (GBP)
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 03/2019 
End 03/2021
 
Description CDT 2014-22
Amount £4,000,000 (GBP)
Funding ID CDT TERM 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2014 
End 09/2022
 
Description Capital equipment CDT
Amount £240,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 11/2015 
End 04/2019
 
Description Capital equipment hip and knee simulators
Amount £920,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2015 
End 04/2020
 
Description Catalyst Medical Technologies
Amount £3,000,000 (GBP)
Organisation Higher Education Funding Council for England 
Sector Public
Country United Kingdom
Start 10/2015 
End 10/2018
 
Description Clothworkers Foundation/UoL - CCTMIH Equipment
Amount £500,000 (GBP)
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 12/2018 
End 12/2019
 
Description DTC 208-2017
Amount £7,000,000 (GBP)
Funding ID DTC 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2008 
End 09/2017
 
Description DTP
Amount £2,000,000 (GBP)
Funding ID DTP 
Organisation DePuy Synthes 
Sector Private
Country United States
Start 01/2014 
End 01/2016
 
Description Development of Prototype Device for Minimally Invasive Delivery of Osteospheres for Treatment of Osteoporosis (MIDOs)
Amount £1,100,509 (GBP)
Funding ID II-C3-0714-20001 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2015 
End 01/2018
 
Description EPSRC - VaxHub Thermostable Formulations
Amount £192,000 (GBP)
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 05/2019 
End 07/2020
 
Description EPSRC Healthcare Technology Challenge
Amount £1,200,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 04/2016
 
Description EPSRC IAA Feasibility Study Award (Steve Russell - Collagen wound dressing)
Amount £10,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description EPSRC cartilage programme
Amount £4,600,000 (GBP)
Funding ID EPG01121721 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2009 
End 06/2015
 
Description European Research Council advanced award
Amount £2,000,000 (GBP)
Funding ID Proposal 267114 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 04/2011 
End 04/2016
 
Description European Rheumatology Research Fountation
Amount € 300,000 (EUR)
Organisation The European League Against Rheumatism (EULAR) 
Sector Private
Country Switzerland
Start 10/2014 
End 09/2017
 
Description Healthcare Impact Partnership
Amount £1,025,492 (GBP)
Funding ID EP/N02480X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2016 
End 05/2021
 
Description Healthcare Technologies Programme Grant
Amount £3,962,447 (GBP)
Funding ID EP/N02480X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2021
 
Description Impact acceleration award
Amount £36,883 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 03/2014 
End 02/2015
 
Description Industry Biocomposites
Amount £150,000 (GBP)
Organisation Biocomposites 
Sector Private
Country United Kingdom
Start 07/2015 
End 07/2016
 
Description Industry Invibio
Amount £300,000 (GBP)
Organisation Invibio 
Sector Private
Country United Kingdom
Start 10/2015 
End 10/2017
 
Description Intrinsic regeneration of osteoarthritic cartilage by unloading involves per-articular stem cell activity: a joint effort.(POC017, McGonagle, UoL)
Amount € 300,000 (EUR)
Organisation Foreum 
Sector Charity/Non Profit
Country Switzerland
Start 01/2015 
End 01/2019
 
Description Marie-Curie IIF
Amount € 220,000 (EUR)
Funding ID BoNE-GrAFT 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 11/2017 
End 10/2019
 
Description Mecical technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices
Amount £4,000,000 (GBP)
Funding ID EP/N00941X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2020
 
Description Medcial engineering centre
Amount £160,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2019
 
Description Medical Research Council Confidence in Concept Award (Steve Russell - Collagen wound dressing)
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Medical Technologies IKC Phase 2 Regenerative Devices
Amount £3,000,000 (GBP)
Funding ID EP/N00941X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 06/2020
 
Description Medical engineering centre
Amount £4,200,000 (GBP)
Funding ID WELMEC 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2015
 
Description NHS Yorkshire & Humber Deanery
Amount £110,000 (GBP)
Organisation NHS England 
Sector Public
Country United Kingdom
Start 03/2015 
End 02/2016
 
Description NHSBT
Amount £200,000 (GBP)
Funding ID EI 
Organisation NHS Blood and Transplant (NHSBT) 
Sector Public
Country United Kingdom
Start 01/2014 
End 01/2017
 
Description NIHR Invention for Innovation (i4i) Programme (Pete Culmer IAP)
Amount £445,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Tissue regenix
Amount £60,000 (GBP)
Funding ID EI 
Organisation Tissue Regenix Ltd 
Sector Private
Country United Kingdom
Start 01/2016 
End 01/2018
 
Description invibio
Amount £400,000 (GBP)
Funding ID LMJ 
Organisation Invibio 
Sector Private
Country United Kingdom
Start 01/2014 
End 12/2016
 
Description mathys
Amount £400,000 (GBP)
Funding ID LMJ 
Organisation Mathys 
Sector Private
Country Switzerland
Start 01/2014 
End 01/2016
 
Description senior investigator
Amount £100,000 (GBP)
Funding ID LMBRU 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 04/2015
 
Title Ankle joint simulation 
Description Ankle joint simulation system 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Wear prediction in total ankle joint 
 
Title Hip Joint simulator 
Description In vitro simulator for artificial hip joints 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Method commercialised by Simulation Solutions 
 
Title Knee joint simulator 
Description artificial knee joint simulator 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Simulator and simulation method commercialised by simulation solution 
 
Title Natural knee simulator 
Description Simulation system for natural knee 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Simulator commercially available, Simulation Solutions 
 
Title POC015 Methods for histological staining of sheep tissue 
Description This relates to new methods, specifically a whole battery of methods to stain sheep tissue were developed that were not available previously. 
Type Of Material Biological samples 
Year Produced 2017 
Provided To Others? No  
Impact New methods developed; whole battery of methods to stain sheep tissue were developed that were not available previously. These methods have been made available to the wider team and subsequent research projects. 
 
Title Patellar simulation 
Description Simulation of mechanics and wear of patellae femoral joint 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2015 
Provided To Others? Yes  
Impact Determination of wear in patellar femoral joint 
 
Title natural hip simulator 
Description Simulation system for natural hip 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2014 
Provided To Others? Yes  
Impact System commercially availa le from Simulation Solutions 
 
Title spine simulator 
Description Spinal disc simulator 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2012 
Provided To Others? Yes  
Impact Commercialised by Simulation solutions 
 
Title Biomechanical and biotribological simulation model natural hip 
Description Biomechanical and biotribological model of natural hip 
Type Of Material Computer model/algorithm 
Year Produced 2013 
Provided To Others? Yes  
Impact used in follow on research 
 
Title Biomechanical model of functional spinal unit 
Description model of functional spinal unit 
Type Of Material Computer model/algorithm 
Year Produced 2014 
Provided To Others? Yes  
Impact used in follow on research 
 
Title Biotribological model naturala knee 
Description Biotribological model natural knee 
Type Of Material Computer model/algorithm 
Year Produced 2014 
Provided To Others? Yes  
Impact Used in follow on research on regenerative devices 
 
Title wear simulation model artificial hip 
Description wear simulation model artificial hip 
Type Of Material Computer model/algorithm 
Year Produced 2010 
Provided To Others? Yes  
Impact applied in industry contract research 
 
Title wear simulation model artificial knee 
Description wear simulation model artificial knee 
Type Of Material Computer model/algorithm 
Year Produced 2012 
Provided To Others? Yes  
Impact used in industry contract research 
 
Description Avacta 
Organisation Avacta Group
Country United Kingdom 
Sector Private 
PI Contribution Electronic Biomarker Detection (eTect); Use of spectroscopy for non-invasive phenotyping of stem cells; Use of di-electrophoresis for minimally manipulated stem cell enrichment.
Start Year 2010
 
Description Biocomposites Ltd 
Organisation Biocomposites
Country United Kingdom 
Sector Private 
PI Contribution Calcium Phosphate Bone Void Filler - A Pin-on-Plate Study; Calcium Sulphate Bone Void Filler Comparison - A Pin-on-Plate Study
Collaborator Contribution participate in research and publication
Impact Publication
Start Year 2014
 
Description Biomet 
Organisation Biomet, Inc
Department Biomet UK
Country United Kingdom 
Sector Private 
PI Contribution Evaluate biomechanics and tribology of new ankle implant.
Start Year 2011
 
Description BoNE-GraFT EU Fellowship 
Organisation Leeds General Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Leeds General Infirmary (Prof. P. Giannoudis) LIRMM (Dr. Elena Jones) New collaboration
Collaborator Contribution The project aims to develop a strong cortical bone templates for integrative manufacturing of bone tissues.
Impact New collaboration
Start Year 2017
 
Description Corin 
Organisation Corin Group PLC
Country United Kingdom 
Sector Private 
PI Contribution Metal on metal hip wear
Collaborator Contribution materials
Impact multidiciplinary
Start Year 2009
 
Description Corline 
Organisation Corline
Country Sweden 
Sector Private 
PI Contribution Heparin coated acellular vascular grafts
Start Year 2011
 
Description Credentis 
Organisation Credentis
Country Switzerland 
Sector Private 
PI Contribution Use of Self assembling peptide(SAP) technology for hard tissue engineering (dental applications)
Collaborator Contribution materilas
Impact Ip piublications
Start Year 2014
 
Description DePUY International Ltd 
Organisation Depuy International
Country United Kingdom 
Sector Private 
Start Year 2004
 
Description DePuy 
Organisation Depuy International
Country United Kingdom 
Sector Private 
PI Contribution Thirty-three projects.
Collaborator Contribution funds , materilas staff
Impact publications
Start Year 2013
 
Description Depuy International Ltd 
Organisation Depuy International
Country United Kingdom 
Sector Private 
Start Year 2004
 
Description IKC Tissue Engineering Leeds for periodontium tissue engineering 
Organisation University of Leeds
Department Medical Technologies IKC
Country United Kingdom 
Sector Academic/University 
PI Contribution The IKC Tissue Engineering team has funded a seed-corn project to support the Marie-Curie Fellowship project of Dr. Antonios Anastasiou. This short-term project is linked with main stream Marie-Curie PReFacto project at Leeds. In this project, the cell growth study is being carried out for ascertaining the suitability of laser-irradiated chitosan/calcium phosphate minerals for engineering a novel tissue template for restoring damaged periodontium.
Collaborator Contribution IKC is funding the seedcorn project.
Impact Not yet
Start Year 2016
 
Description Invibio 
Organisation Invibio
Country United Kingdom 
Sector Private 
PI Contribution Four projects: PEEK low con knees; Investigation of biocompatibilty of PEEK wear debris; Investigation of PEEK as cervical disc bearing material; Low Cost Polymer Knee
Start Year 2010
 
Description LMBRU LTHT 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution patient specific and population based simulation an d modelling publications and outputs
Collaborator Contribution clinical imaging patient data retrieval bank patient participation
Impact publications simulation methods new standards joint grant applications
Start Year 2015
 
Description Mathys Medical 
Organisation Mathys
Country Switzerland 
Sector Private 
PI Contribution Four projects including: Evaluation of potential ceramic matrix hips Ceramic matrix composite hip Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys IV) Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys V)
Collaborator Contribution materials , research methods , analysis
Impact papres
Start Year 2013
 
Description NAMSA 
Organisation North American Science Associates Inc
Country United States 
Sector Private 
PI Contribution In vivo testing of dCell bone to detremine osseointegration and biocompatibility
Collaborator Contribution undertaking research work
Impact pubication
Start Year 2015
 
Description NHS NBTS 
Organisation NHS Blood and Transplant (NHSBT)
Department National Blood Service
Country United Kingdom 
Sector Public 
PI Contribution 8 projects in collaboration with NHS NBTS Acellular bone ligament graft (Human) Acellular bone meniscus bone graft (Human) Acellular OC graft (Human) Allo vascular graft Allo heart valve Biocompatibility of acellular allogeanic dermis Acellular allogeneic aorta Development of dCELL bone-patella-bone allograft for anterior cruciate ligament replacement
Collaborator Contribution funds time
Impact multidiciplinary
Start Year 2010
 
Description National Blood Service 
Organisation NHS Blood and Transplant (NHSBT)
Department National Blood Service
Country United Kingdom 
Sector Public 
Start Year 2003
 
Description Neotherix 
Organisation Neotherix Ltd
Country United Kingdom 
Sector Private 
PI Contribution Repair of oral and peridontal defects using regenerative and antibacterial strategies delivered by a novel tissue scaffold vehicle Polymeric scaffolds functionalised for periodontal repair
Collaborator Contribution materials
Impact multidisciplinary
Start Year 2015
 
Description Neu Biomechanics, BiteCiC 
Organisation Neu Biomechanics
Country United Kingdom 
Sector Private 
PI Contribution Evaluation of coating wear
Start Year 2010
 
Description RD Biomed 
Organisation RD Biomed
Country United Kingdom 
Sector Private 
PI Contribution Use of a novel therapeutic device for treatment of periodontal disease Penetration of a new market (dental) for an existing diagnostic device
Start Year 2010
 
Description Simpleware 
Organisation Simpleware Ltd
Country United Kingdom 
Sector Private 
PI Contribution Development of finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort
Collaborator Contribution software
Impact papers
Start Year 2014
 
Description Simulation Solutions 
Organisation Simulation Solutions
Country United Kingdom 
Sector Private 
PI Contribution 10 projects in collaboration with Simulation Solutions: High flex knee simulator Natural knee simulator Natural hip simulator Natural spine simulator Natural joint friction simulator knee joint simulator SOP for hip simulator SOP for knee simulator Natural Knee Simulation System Electro mechanical hip simulator method SOP and training
Collaborator Contribution equipment development
Impact publications
Start Year 2014
 
Description Supply of GMP Collagen 
Organisation Collagen Solutions
Country United Kingdom 
Sector Private 
PI Contribution Information of collagen materials manufacturing
Collaborator Contribution FoC supply of commercial grade GMP collagen
Impact Manufacture of collagen fibres and gels
Start Year 2014
 
Description Tissue Regenix 
Organisation Tissue Regenix Ltd
Country United Kingdom 
Sector Private 
PI Contribution A total of 12 projects collaborating with Tissue Regenix Acellular ligament graft (Animal) Acellular bone meniscus bone graft (Animal) Acellular OC graft (Animal) Xeno vascular patch Xeno heart valve Decellularised bladder Decellularised meniscus (see also 12b) Acellular porcine flexor tendon graft Development of the dCELL Partial Meniscus In vivo testing of dCell bone to determine osseointegration and biocompatibility In vivo evaluation of decellularised porcine pulmonary roots. Long Term Evaluation of an Acellular Bovine Arterial Graft in an Ovine Arteriovenous Access Model
Start Year 2009
 
Description Tissue Regenix Ltd 
Organisation Tissue Regenix Ltd
Country United Kingdom 
Sector Private 
PI Contribution research
Collaborator Contribution materials Ip
Impact papers
Start Year 2014
 
Description Understanding repair activity in knee joint distraction 
Organisation University Medical Center Utrecht (UMC)
Country Netherlands 
Sector Academic/University 
PI Contribution We discovered synovial fluid (SF) in OA contains MSCs, of which the number is elevated in the early stages of OA (Churchman S, Arthritis Rheumatism 2012; Jones E, Arthritis Rheumatism 2004). The discovery of this resident population of highly proliferative MSCs in SF whereby such cells have reproducibly good chondrogenic activity (Churchman S, A&R 2012) supports the concept that such MSCs, having a direct access to the damaged cartilage areas, and so may be key players in the reparative process as a result of joint distraction. Crucially, our collaboration (UK/NL) has recently shown that SF resident MSCs adhere to sites of cartilage injury in a canine OA model and that this adhesion is related to synovial fluid hyaluronan.
Collaborator Contribution Our collaborators have demonstrated that application of unloading by knee joint distraction (6-8 wks) leads to prolonged (>5 yrs currently) intrinsic cartilage repair in combination with meaningful clinical efficacy in osteoarthritis in humans (Mastbergen S, Nat Rev Rheumatol 2013; Intema F, ARD 2011; Wiegant K, OAC 2013). As this intrinsic cartilage repair activity is unique but not fully understood.
Impact Submitted manuscript, Annals of Rheumatic Disease. Synovial fluid hyaluronan regulates multipotential stromal cell attachment to cartilage. A novel mechanism contributing to knee joint distraction repair in osteoarthritis.
Start Year 2011
 
Title Acellular Vascular Products 
Description A product comprising a natural acellular xenogenic vascular tissue matrix having at least an80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery. 
IP Reference WO2012042250 
Protection Patent application published
Year Protection Granted 2012
Licensed Yes
Impact This IP has been assigned to Tissue Regenix (AIM listed Leeds spin out company), which is developing a portfolio of products based on this IP as well as three other patents we have assigned. Products such as a vascular patch for peripheral vascular reconstruction (clinical trial in 2009).
 
Title Acellular Vascular Products 
Description Method for producing acellular arteries 
IP Reference WO2002096476 
Protection Patent granted
Year Protection Granted 2011
Licensed Yes
Impact Now under commercial development by Tissue Regenix group PLC Also under development by NHS Blood & Transplant Tissue Services for application to allogeneic donor arteries
 
Title Acellular porcine meniscus for meniscal repair/replacement 
Description The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised. 
IP Reference WO2008059244 
Protection Patent granted
Year Protection Granted 2009
Licensed Yes
Impact This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix.
 
Title Beta Sheet Tape Ribbons in Tissue Engineering 
Description There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a ß-sheet tape-like substructure. 
IP Reference WO2004007532 
Protection Patent granted
Year Protection Granted 2009
Licensed Yes
Impact A spin-out company (Credentis AG).
 
Title Combination of material for joint prosthesis 
Description An orthopaedic joint prosthesis comprises first and second articulating components having respective bearing surfaces in contact with one another. The material of the first bearing surface (14) comprises a metallic material and the material of the second bearing surface (6) comprises a ceramic material. The hardness of the metallic material is at least about 2500 MPa, and the hardness of the ceramic material is greater than that of the metallic material by at least about 4000 MPa. 
IP Reference WO2001017464 
Protection Patent granted
Year Protection Granted 2006
Licensed Yes
Impact Clinical trials started 2006. Now marketed world wide. FDA IDE study underway in USA. A revenue sharing arrangement is in place between us and DePuy International.
 
Title Composite connective Tissue and Bone Implants 
Description Method for the decellularisation of bone-meniscus-bone; bone-tendon-bone and bone-cartilage 
IP Reference WO2014037713 
Protection Patent application published
Year Protection Granted 2013
Licensed No
Impact Proof of concept phase in large animal model completed for bone-tendon-bone, discussions ongoing with a company on development re licensing
 
Title Composition 
Description The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth. 
IP Reference WO2012046082 
Protection Patent application published
Year Protection Granted 2012
Licensed Yes
Impact This IP is supporting three projects: an EPSRC Health Technology Challenge project, an Innovate UK project, and a European funded Marie-Curie award with industrial partners which aims to produce commercial products. IPGroup and commercialisation team scoping out POC in vivo trial to evaluate the technology with the possibility of forming a spin-out company, two other patents would also be bought into this project.
 
Title Decellularised human livers 
Description The process could be applied to human donor organs thus increasing the number of such organs available for transplantation. This IP has not been patented and may still be confidential. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2014
Licensed No
Impact Too early for notable impacts.
 
Title Improvements in and Relating to Collagen Based Materials 
Description There are provided collagen based polymeric materials comprising collagen molecules and/or collagen derived molecules which have been functionalised by the addition of one or more ethylenically unsaturated moieties and which have been cross-linked via said moieties. Also provided are collagen based compositions and methods of producing collagen based polymeric materials. 
IP Reference WO2014147415 
Protection Patent application published
Year Protection Granted 2014
Licensed No
Impact NDA signed with potential industrial partner. MTA signed with a manufacturer (discussions in progress) and a manufacturing feasibility evaluation currently underway.
 
Title Leeds Virtual Microscope 
Description Novel software for viewing images 
IP Reference US8970618 
Protection Patent granted
Year Protection Granted 2015
Licensed Commercial In Confidence
Impact IP portfolio assigned to Roche (Ventana Medical Systems) as part of asset sale of technology, deal completed July 2015. EP and GB patents still pending. US patent granted.
 
Title Low concentration SDS and Protease inhibitors for decellularisation 
Description A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors. 
IP Reference WO2002096476 
Protection Patent granted
Year Protection Granted 2007
Licensed Yes
Impact A portfolio of products is in development for different clinical needs. A spin-out company has been formed (Tissue Regenix) which has a licence of this and three other patents. Also, this IP has been licensed to NHS Blood and Transplant, Tissue Services, for allografts in the NHS in the UK.
 
Title METHOD AND APPARATUS FOR MANIPULATING PARTICLES 
Description A method and apparatus for manipulating polarizable dielectric particles. The method includes positioning a liquid containing the particles above a surface of a piezoelectric material (2). The method also includes inducing a shear-horizontal surface acoustic wave in the piezoelectric material (2), thereby to form a time-varying non-uniform evanescent electric field extending into the liquid. The method further includes using the time-varying non-uniform evanescent electric field to apply a force to at least some of the particles (50, 52) by dielectrophoresis. 
IP Reference WO2015022481 
Protection Patent application published
Year Protection Granted 2015
Licensed Yes
Impact Spin out of company based on this technology called Relitect.
 
Title Magnetometer for medical use 
Description A medical magnetometer (10) comprising one or more induction coils (2) for detecting a time varying magnetic field of a region of a subject's body, such as the heart. Each coil has a maximum outer diameter of 4 to 7 cm, and a configuration such that the ratio of the coil's length to its outer diameter is at least 0.5, and the ratio of the coil's inner diameter to its outer diameter is 0.5 or less. Each induction coil (2) is coupled to a respective detection circuit comprising a low impedance pre-ampiifier (3), a low pass filter (5), a notch filter (6) to remove line noise, and an averaging element (7). Each detection circuit produces an output signal (9) for use to analyse the time varying magnetic field of the region of the subject's body. 
IP Reference WO2014006387 
Protection Patent application published
Year Protection Granted 2014
Licensed Yes
Impact IP is currently licensed to a Leeds spin-out (Creavo Medical Technologies Ltd, previously known as Quantum Imaging Ltd). Primary focus at present is the development of cardiac focussed devices, such as the VitalScan machine to support rule out triaging of patients presenting with chest pain in an emergency room setting.
 
Title Method and apparatus for manipulating particles (DEP-SAW) 
Description This invention relates to a method and apparatus for manipulating particles. The patent has not been published yet so may still be confidential. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2013
Licensed No
Impact The manipulation of particles finds application in a wide range of fields, many of which are medical in nature.
 
Title Methods and devices for detecting structural changes in a molecule measuring electrochemical impedance 
Description The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays. 
IP Reference WO2008032066 
Protection Patent application published
Year Protection Granted 2008
Licensed No
Impact This IP should support a spin-out company (Phase DX) in the near future.
 
Title ORTHOPAEDIC MEDICAL DEVICE 
Description This present invention provides an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site or an injury site. The invention includes methods of increasing a cell population at a surgical site or injury, a method of improving surgical outcome of synovial joint procedures and methods of delivering intra-operative minimally manipulated cells to a synovial joint. 
IP Reference US2018161022 
Protection Patent application published
Year Protection Granted 2018
Licensed Yes
Impact Xiros have an exclusive license to use and sell, in all species but University still are able to use technology for research and teaching.
 
Title On-chip spectroscopy system 
Description This IP has not been patented and may still be confidential. 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No notable impacts as yet.
 
Title Orthopaedic medical device 
Description A UK priority patent filing has been made but not yet published. The invention relates to an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2014
Licensed No
Impact A first in man clinical trial is being planned.
 
Title Porcine bladder biomaterial 
Description The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro. 
IP Reference WO2007110634 
Protection Patent granted
Year Protection Granted 2007
Licensed Yes
Impact This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix to date.
 
Title Regional anaesthetic delivery system 
Description Unpatented know-how on a regional anaesthetic delivery system. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2013
Licensed No
Impact Confidentiality agreements in place with various potential partners but no notable impacts yet.
 
Title SURGICAL RETRACTION DEVICE AND PROCEDURE 
Description The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length. 
IP Reference WO2017134415 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact None yet, commercial device undergoing prototyping. Patent arose based on refinements made during i4i project, continuing work performed during IKC POC project.
 
Title Scaffold proteins derived from plant cystatins 
Description The present invention relates to scaffold proteins derived from plant cystatins and to nucleic acids encoding them. The scaffolds are highly stable and have the ability to display peptides. The scaffolds are particularly well suited for constructing libraries, e.g. in phage display or related systems. The invention also related to various uses of the scaffolds, including in therapy, diagnosis, environmental and security monitoring, synthetic biology and research, and to cells and cell cultures expressing the scaffold proteins. 
IP Reference WO2014125290 
Protection Patent application published
Year Protection Granted 2014
Licensed Yes
Impact This IP was exclusively licensed to Avacta Life Sciences Ltd in the field of life sciences research reagents and diagnostics. Avacta pay royalties based on the University providing a screening service to Avacta and also for catalogue sales.
 
Title Surgical Retraction Device and Procedure 
Description The invention provides a retraction device (1) adapted for use in minimally invasive surgery, said device comprising: (a) access means ( 3 ); (b) rigid support means; (c) expandable retraction means (2) comprising a multiplicity of radially oriented members (10); (d) flexible attachment means (6); and (e) a multiplicity of magnetic means, wherein said expandable retraction means in its non- expanded form is attached to said rigid support means by said flexible attachment means and is insertable into a subject through said access means, and wherein said multiplicity of magnetic means are comprised in said expandable retraction means. The invention also provides expandable retraction means comprising a multiplicity of radially oriented members and a method for the use of a retraction device in minimally invasive surgery, the method comprising the steps of providing a retraction device according to the first aspect of the invention, inserting said expandable retraction means via said access means through the cavity wall of a subject, deploying the expandable retraction means in its expanded form, magnetising the tissue to be retracted and attaching the magnetised tissue to the retraction device. The device and method according to the invention satisfy the necessary criteria for use in MIS applications and provide for ease in both manufacture and use, and potential application in many areas of MIS. 
IP Reference WO2017134415 
Protection Patent application published
Year Protection Granted 2012
Licensed No
Impact Two companies are potentially interested in using this IP.
 
Title Tissue sensors for medical diagnosis 
Description Optical sensors for the diagnosis of a range of medical conditions. 
IP Reference  
Protection Protection not required
Year Protection Granted 2012
Licensed No
Impact A licence, with revenue sharing provisions, with another University.
 
Title Ultrasonic modification of soft tissue matrices 
Description The present invention provides a method of, and apparatus for, utilising ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularised in continuous form. The present invention also provides for the production of tissue matrices with improved recellularisation properties, cell stratification or patterning. 
IP Reference WO2004103461 
Protection Patent granted
Year Protection Granted 2007
Licensed Yes
Impact This IP is used in various of our Proof of Concept projects. It has also supported a spin-out company, and a portfolio of products is under development by them.
 
Title Virtual Microscopy 
Description Computer implemented methods and data processing apparatus are described for displaying virtual slide images. Images of a plurality of slides are automatically displayed in a first region of a display device at a first magnification. The slides comprise all the slides including material from a same specimen. An image of at least one of the slides is displayed in a second region at a second magnification greater than the first magnification. At least the image displayed in the second region is changed responsive to receiving user input. Methods for automatically determining a slide layout pattern and methods for virtually melding glass slide images into a single image are also described. 
IP Reference US8970618 
Protection Patent application published
Year Protection Granted 2011
Licensed No
Impact IP portfolio assigned to Roche (Ventana Medical Systems) as part of asset sale of technology, deal completed July 2015. EP and GB patents still pending. US patent granted.
 
Title Visual parameter optimisation software 
Description Software and an algorithm for use with image analysis/process engineering. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2013
Licensed No
Impact This software was developed for the optimization of image processing algorithms. Today, this is done in a time-consuming way that relies on trial-and-error. Our software enables users to make better choices of parameter values, to do so faster, and to better understand the influence of the parameters on image processing. The software is applicable to image processing, in general, although our research has focussed on applications in biomedical research.
 
Title Arthroscopic device for stimulating synovial mesenchymal stem cells in the knee 
Description The arthroscopic device is currently (as of Jan 2017) in a small scale clinical evaluation study at Leeds Teaching Hospitals funded through NIHR funded Leeds Musculoskeletal Biomedical Research Unit, led and managed by Prof Dennis McGonagle, Dr Tom Baboolal with Consultant Mr Owen Wall. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact IKC funded Proof of Concept (POC) Project supported early development of the new medical device. This supported device design and testing, prototype manufacture and subsequent manufacture of devices for use in the clinical evaluation. The POC also supported generation of data used in patent filing. 
 
Title ISO accredited simulation test laboratory 
Description ISO accredited simulation test laboratory for pre clinical testing and trials widely used by customers around globe 
Type Support Tool - For Medical Intervention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2013
Development Status Under active development/distribution
Impact uptake by wide range of companies 
 
Title Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair (AURA). ClinicalTrials.gov Identifier: NCT02696876 (POC017, McGonagle, UoL) 
Description Exclusive world wide licence agreement of patent with medical device company Xiros Ltd. . Device currently being assessed in clinical trials, funded through NIHR Leeds Biomedical Research CEntre The device stimulates resident synovial stem cells and releases them into the joint space to facilitate repair and regeneration of cartilage and other structures in the knee. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Under active development/distribution
Clinical Trial? Yes
Impact LIcence of technology to Xiros for commercialisation 
URL https://clinicaltrials.gov/show/NCT02696876
 
Title acellular bone 
Description under development and in in vivo trials 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under development and in animal trials 
 
Title acellular bone cartilage osteochondral graft 
Description under development 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under developemnt 
 
Title acellular bone cartilage osteochondral graft 
Description under development NHSBT 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact under development 
 
Title acellular bone patellar bone graft 
Description under development by NHSBT 
Type Therapeutic Intervention - Surgery
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under development by NHSBT 
 
Title acellular dcell vascular patch 
Description licensed to and commercialised by Tissue Regenix 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Clinical Trial? Yes
Impact First dcell clinical product 
URL https://clinicaltrials.gov/show/NCT00958230
 
Title acellular dcell dermis 
Description commercialised by Tissue regenix from 2014 
Type Therapeutic Intervention - Medical Devices
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact sold and distributed in USA 
 
Title acellular dermis 
Description supplied as clinical product by NHSBT 
Type Therapeutic Intervention - Surgery
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact supplied by NHSBT, improved wound healing in chronic leg ulcers 
 
Title acellular heart valve 
Description clinical application through human tissue bank 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact proof of clinical use acellular technology 
 
Title acellular vascular graft 
Description under development by NHSBT and Tissue Regenix 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact Under development by NHSBT an dTissue Regenix 
 
Title all polymer knee 
Description collaborative development with Invibio 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact collaborative development with Invibio 
 
Title ceramic on ceramic hip 
Description Mathys 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Market authorisation
Year Development Stage Completed 2012
Development Status Under active development/distribution
Impact successfully adopted an d commercilised 
 
Title ceramic on ceramic and ceramic on metal hip 
Description commercialised by DePuy and by Mathys 
Type Therapeutic Intervention - Medical Devices
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact successfully adopted an d commercilised 
 
Title dcell ligament 
Description Under commercial development by tissue Regenix, progressing to CE mark and product launch 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact under commercial development by Tissue Regenix in clinical trial started 2015 proceeding to Ce mark and product launch 2017 
URL https://clinicaltrials.gov/show/NCT02540811
 
Title dcell meniscus 
Description Developed by tissue Regenix In clinical trial started 2015 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact first in man clinical trial started 2015 
URL https://clinicaltrials.gov/show/NCT02270905
 
Title finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort 
Description This project has been led by Dr Ruth Wilcox in partnership with Simpleware Limited. The development of the software add-on has been completed and the final validations with the Leeds data set-set are coming to an end. It is anticipated that a technology demonstrator project will now be undertaken with a company that can demonstrate the utility of the software for evaluating spinal implants. The commercial team is now engaged and discussions with Simpleware around a possible license deal are on-going. It is envisaged that as part of this license deal Simpleware will engage Leeds expertise as part of their offer to companies. In addition Leeds personnel will retain the right to undertake consultancy in their own capacity. 
Type Of Technology Software 
Year Produced 2013 
Impact further research 
 
Title hip joint simulator 
Description hip joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2012 
Impact commercial product Simulation solutions 
 
Title knee joint simulator 
Description knee joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2013 
Impact Commercial product simulation solutions 
 
Title natural hip simulator 
Description natural hip simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2014 
Impact commercial product simulation solutions 
 
Title natural knee simulator 
Description natural knee simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2013 
Impact commercialised by simulation solutions 
 
Title spinal disc simulator 
Description spinal disc simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2010 
Impact commercial product simulation solutions 
 
Company Name Creavo Medical Technologies Ltd (formerly Quantum Imaging) 
Description Creavo Medical Technologies Ltd is a UK-based, privately held medical device company engaged in the development of innovative imaging technologies. The company was formed to commercialise sensor technology developed by Professor Ben Varcoe, Chair of Quantum Information Science at Leeds University and has facilities in Leeds and in Warwickshire UK. The first application of this technology will be to aid the rapid triage and identification of patients presenting to Emergency Departments with chest pain, but who ultimately have no cardiac related diagnosis. Identifying these patients early enables them to leave expensive cardiac diagnostic pathways so releasing resources to focus on other acute patients. Creavo Medical Technologies has an experienced management team, with a mix of fundamental research, medical device commercialisation, manufacturing and global regulatory and clinical strategy. 
Year Established 2014 
Impact A new cardiac scanning device that could save the NHS £200 million a year is being trialled at four of the UK's largest emergency departments (Bristol, Nottingham, Leicester and Sheffield). The British-made Vitalscan device, which has been developed by Creavo Medical Technologies and could revolutionise the way patients with chest pain are managed in emergency departments, works by conducting a non-invasive three to five-minute scan at a patient's bedside to rule out significant cardiac conditions, such as heart attacks. Data from the York Health Economics Consortium shows that 1.3 million A&E admissions in 2014/15 were due to chest pain. Of these, 63% ultimately had no cardiac-related condition but, the majority would still have gone through the same costly cardiac triage process of someone having a heart attack. Vitalscan has the potential to identify a significant proportion of these patients which would radically change the management of chest pain patients entering emergency departments. Conservative estimates indicate that the device could save the NHS £200 million a year, the equivalent of £3.85 million a week and £382 a minute, easing pressure on bed space in A&E departments and reducing patient anxiety by getting patients to the correct treatment more quickly. Steve Parker, CEO Creavo Medical Technologies says: "Cardiac-related chest pain is one of the biggest issues facing emergency departments in the western world due to the economic burden it places on healthcare services and the disruption it causes to inpatient care. "The triage process for someone entering an emergency department with chest pain can take anywhere from six to 24 hours which places a huge amount of strain on resources. "Early results from smaller sets of clinical trials indicate that Vitalscan can quickly identify and rule out significant ischemic heart disease so it prevents patients who aren't suffering from a cardiac-related condition from having to go through the lengthy, costly chest pain triage process, easing the burden on emergency departments at a time when they are facing unprecedented pressures." Creavo Medical Technologies was established to commercialise the work undertaken by Professor Ben Varcoe at the University of Leeds to develop Vitalscan, a portable, passive magnetocardiography device that measures the electromagnetic fluctuations of the heart, while maintaining the accuracy and efficacy of older SQUID devices. The start of clinical trials at Sheffield Teaching Hospitals NHS Foundation Trust, University Hospitals of Leicester NHS Trust, North Bristol NHS Trust and Nottingham University Hospitals NHS Trust marks the largest ever clinical trial of a magnetocardiography device. This will be followed by a second stage starting at three centres in the United States at Mayo Clinic Rochester, Cincinnati and Baylor Texas.
Website http://creavomedtech.com/
 
Company Name Tissue Regenix 
Description Developemnt and manufacture of Regenerative Biological Scaffolds for tissue repair in vascular, cardiovascular and musculoskeletal systems 
Year Established 2007 
Impact aim listed d raised £0m investment value £150m 4 clinical products
 
Company Name Relitect Ltd 
Description Relitect Ltd are developing a novel technology for the detection of binding events, which can be used for the analysis of proteins, small molecules and nucleic acids. The Relitect proprietary technology enables highly sensitive detection of biomarkers or other analytes in a label free multiplexed format, using small sample volumes. Relitect's approach has potential for utilisation across the clinical diagnostics and life sciences industries. 
Year Established 2014 
Impact March 2015 - Relitect secured a £750K tranched investment from IP Group Plc and Scottish Enterprise's investment arm, the Scottish Investment Bank to develop its novel high sensitivity diagnostic/science technology. 20th April 2015 - Relitect moves to new laboratory facilities at Biocity Scotland -www.biocity.co.uk/biocity/scotland
Website http://www.relitect.com/
 
Description 30th Annual Meeting of the Wound Healing Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation by Dr. Tronci on Photoactive Type I (atelo) collagen as Building Blocks of Advanced Wound Dressings
Year(s) Of Engagement Activity 2018
 
Description Arthroscopic Brush can promote stem cell healing. 2017. Regen Magazine. Issue 08, pages 20-21. (POC017, McGonagle; UoL) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Arthroscopic Brush can promote stem cell healing. 2017. Regen Magazine. Issue 08, pages 20-21.
Year(s) Of Engagement Activity 2017
URL https://issuu.com/medtechleeds/docs/regen_magazine_web
 
Description Article: Regen Med Nears the Market - GEN 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Article published by Genetic Engineering and Biotechnology news about the IKC and Regener8

Increased memberships to Regener8
Year(s) Of Engagement Activity 2012
URL http://www.genengnews.com/gen-articles/regen-med-nears-the-market/4597/
 
Description Ask the Expert - Clinically Led Manufacture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Four separate presentations given by:
- Prof Nikos Donos, Head of the Clinical Oral Research Center at the Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London (QMUL) in collaboration with SJ Russell.
- SJ Russell (Leeds)
- P Giannoudis (Leeds)
- M. Mehr (Geistlich Pharma AG)
Year(s) Of Engagement Activity 2018
URL http://mede-innovation.ac.uk/event/mede-innovation-ask-expert-oct-18/
 
Description Daily Mail. 30/01/2019: Tiny rake to repair crumbly old knees by collecting stem cells from the joint (POC017, McGonagle UoL) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Daily Mail article - Tiny rake to repair crumbly old knees by collecting stem cells from the joint
Year(s) Of Engagement Activity 2019
URL https://www.dailymail.co.uk/health/article-6642205/Tiny-rake-repair-crumbly-old-knees-collecting-ste...
 
Description Event Exhibition: Healthcare Innovation Expo, ExCel London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Europe's largest, most exciting healthcare innovation event 13th & 14th March 2013. The IKC hosted an exhibition stand at the event to connect to potential clinical partners.

Increased understanding of clinical needs. Increased engagement with clinicians.
Year(s) Of Engagement Activity 2013
URL http://www.nic.nhs.uk/Pages/ArchivedNews-4.aspx
 
Description Event Exhibition: Innovate 13, Business Design Centre, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact 4,000 people from UK and international business, Government and academia attended to do business.

Made contacts now members of the IKC community.
Year(s) Of Engagement Activity 2011,2013
URL https://www.innovateuk.org/-/innovate-uk-11th-13th-march-2013
 
Description Hosted laboratory visit for Leeds Biomedical Research Centre Patient Public Involvement group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Hosted a laboratory tour and series of talks from academic members of the Institute of Medical and Biological Engineering for members of the Leeds PPI group
Year(s) Of Engagement Activity 2018
URL https://youtu.be/cKfs50-NxJQ
 
Description Invited talk at conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "A new regenerative medicine approach for urinary incontinence" presented at Incontinence: the Engineering Challenge XI Conference, Institution of Mechanical Engineers, London.
Year(s) Of Engagement Activity 2017
URL http://events.imeche.org/ViewEvent?code=CON6475
 
Description Keynote Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Society of Glass Technology holds annual conference in UK in which international participants present their work. In a 3-day International Meeting I gave a Keynote Lecture on the Phase Transformation in Calcium Phosphate based gels and colloids. The results from the EPSRC and EU funded projects were presented. I explained the mechanism of ultra-fast phase transformation arising as a result of irradiation from near-IR mode-locked lasers.
A new approach for studying the phase transformation was studied and analysed by using thermal analysis techniques.
Year(s) Of Engagement Activity 2015
URL http://www.glassreflections.sgt.org/
 
Description Living With and Beyond Cancer Event. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Took part in a celebration day at York Hospital to demonstrate the work of various groups in support of people living with and beyond cancer.
Year(s) Of Engagement Activity 2018
 
Description MeDe Innovation Launch Conference (Leeds) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Launch of MeDe Innovation: Delegates heard from respected industry and academic experts and learnt how the Centre is stimulating translation and connecting the medical device community in the UK in order to accelerate manufacturing processes through to business and the clinic.
Year(s) Of Engagement Activity 2014
 
Description MeDe Innovation Launch Conference (Nottingham) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The MeDe Innovation Annual Conference 2015 'Advancing Orthopaedic Medical Device Manufacturing' will bring you up to the minute developments in the changing landscape of design and manufacture for orthopaedic medical devices.

Our interdisciplinary one-day conference brings together experts from funders, research, industry, clinical, and regulation. A year on from our launch event, delegates will have the opportunity to consider:

Medical Devices - An industry with unlimited potential:

Opportunities and challenges in

stratified design and innovative manufacture of orthopaedic medical devices
in-clinic manufacture of personalised orthopaedic devices
use of biological and biomimetic materials in medical devices and health technologies

Getting great products to patients:

Regulatory perspectives from the MHRA towards personalised and combination approaches for medical devices
Changes to the pre-market approvals process to access opportunities in the USA from the FDA Centre for Devices and Radiological Health

Creating new industries from pioneering innovative manufacturing research in the UK:

Showcase of how EPSRC are creating a prosperous future for the UK through ground-breaking innovative manufacturing research
How breadth of research is growing new technology-led companies, improving healthcare delivery and allowing economic competitiveness in the UK
Presentations from research specialists in Additive Manufacturing, Composite Manufacturing and more

Growing and supporting the national community

Announcement of the Fresh Ideas Award winners from the Centre Co-Director
Growing a Medical Devices and Regenerative Clinical Network led by the Centre Clinical Director
Launch of the National MSK Medical Device Capability Database from the Centre National Outreach Manager
Ample networking opportunities, exhibitions and panel discussion sessions
Year(s) Of Engagement Activity 2015
 
Description Public lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Public lecture to University of Huddersfield.
Year(s) Of Engagement Activity 2017
URL http://www-old.hud.ac.uk/events/?view=fulltext&month=11&day=1&year=2017&id=d.en.224960×tamp=151...
 
Description Regen - Regener8 Annual Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Glossy review of annual activity of the Regener8 programme. Review sponsored by the MTIKC
Year(s) Of Engagement Activity 2014,2015,2016
 
Description TI World Conference Programme - Keynote 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote presentation on textile medical devices and healthcare to the World Textile Institute Conference
Year(s) Of Engagement Activity 2018
URL http://www.tiworldconference.org/wp-content/uploads/2015/04/TIWC-2018-Programme-Final1.pdf
 
Description Talk at British Association for Surgery of the Knee (BASK), 2018 Annual Conference.(POC017 McGonagle, UoL) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk at British Association for Surgery of the Knee
Year(s) Of Engagement Activity 2018
 
Description Talk to Surgical Sixty Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk to Surgical Sixty Club
Year(s) Of Engagement Activity 2016
 
Description Television programme "Who wants to live forever" ITV 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact ITV Tonight Programme, aired 7:30pm, Thursday 5 July 2012. A look at how thousands are now celebrating their one hundredth birthday. John Fisher and Eileen Ingham present their research around "50 Active years after 50" as part of the programme.

Further requests from TV producers about health innovations of the future.
Year(s) Of Engagement Activity 2013
URL https://www.itv.com/itvplayer/tonight/series-16/episode-5-who-wants-to-live-forever-
 
Description Termis - Americas 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tronci G; Liang H; Wood DJ; Russell SJ (2017) Functionalised Collagen Systems With Bespoke Molecular And Macroscopic Characteristics For Chronic Wound Management 2017 TERMIS - Americas Conference & Exhibition, pp. S74-S74. Charlotte, NC
Year(s) Of Engagement Activity 2017
 
Description Urothelial cross-disciplinary research meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Researchers met clinical professionals (pathology, paediatric urology, transplantation, adult urology and NHS R&D) for workshop to discuss ongoing bladder research and opportunities for engagement and translation. The activity sparked enthusiastic debate and identified minuted actions for individuals, with two follow on studies initiated.
Year(s) Of Engagement Activity 2019
 
Description Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Workshop on basic science to a trainee clinical audience at the European Society for Paediatric Urology, Harrogate.
Year(s) Of Engagement Activity 2016
 
Description public engagement 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Civic visit to the laboratory by Lord Mayor of York and Sheriff plus their partners, with reporter.
Year(s) Of Engagement Activity 2016
 
Description public engagement talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk to York Vikings Rotary Club
Year(s) Of Engagement Activity 2016