Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
This project is all about multi-disciplinary collaboration - and capitalisation in a clinical setting of the many new vistas and opportunities that will arise. As such this research programme brings together a group of world class scientists (physicists, chemists, engineers and computer experts) and clinicians to design, make and test a cutting-edge bedside technology platform which will help doctors in the intensive care unit (ICU) make rapid and accurate diagnoses that would inform therapy and ensure patients get the right treatment, quickly. While we are developing our technology platform with a focus on ICU, it will also be applicable to a wide range of other healthcare situations.
ICU patients suffer high death and disability rates and are responsible for a disproportionate financial burden on the health service. Potentially fatal lung complications are a common problem in ventilated ICU patients and doctors caring for these patients in the ICU face many challenges, often needing to make snap decisions without the information necessary to properly inform those decisions. The technology platform developed in this programme will provide doctors with important information on the state of ICU patients and whether they have infections, inflammation or scarring in their lungs. Currently there are no methods to do this accurately. This information will aid them in making decisions about treatment. A new approach to rapidly diagnose lung complications in ICU would enable doctors to target the correct drugs to the appropriate patients and to withdraw drugs with confidence, with resultant improvement in patient outcomes and major cost efficiencies - thus revolutionising ICU care.
Using advanced fibre optic technology and micro-electronics and new sensor arrays our ground-breaking solution is to create a novel fibre-based probe that can readily be passed into the gas exchanging areas of the lung and blood vessels of ICU patients. The probe will house a variety of special optical fibres, some of which allow clinicians to "view" inside the lung while others will be modified with sensors that can measure important parameters such as oxygen concentration and acidity in both blood and lung. In addition the fibre will deliver tiny amounts (microdoses) of 'smart reagents' that fluorescently detect specific bacteria and other agents that can damage the lung. When integrated together these signals will provide highly specific information about the degree or type of lung damage and the potential causative 'bug' if an infection is suspected. Because of the large amount of information generated and in order to make it easily interpreted by doctors, computing experts will convert these signals into easy-to-understand disease readouts for our clinicians.
Work on the different elements needed to create this technology platform will be undertaken by groups of chemists, physicists, engineers, computer scientists and biologists working at Bath, Heriot Watt and Edinburgh universities. Crucially, this programme will bring these scientific disciplines together in a "hub" where they will work side-by-side, promoting integration of purpose and to ensure that advances are rapidly translated into the clinical setting. This interdisciplinary hub will also provide a fertile training base for new PhD students who will learn the cross-disciplinary skills that will equip them to meet the challenges of translating the current 'revolution' in physical sciences into benefit for UK healthcare.
In summary this project will generate; 1) a new cohort of scientists trained in physical and biological science that have a full appreciation of clinical translational and commercialisation pathways and who are equipped to meet the challenges of converting advances in basic science into healthcare benefit and; 2) a cutting-edge bedside technology platform which will help doctors in the ICU make rapid and accurate diagnoses.
ICU patients suffer high death and disability rates and are responsible for a disproportionate financial burden on the health service. Potentially fatal lung complications are a common problem in ventilated ICU patients and doctors caring for these patients in the ICU face many challenges, often needing to make snap decisions without the information necessary to properly inform those decisions. The technology platform developed in this programme will provide doctors with important information on the state of ICU patients and whether they have infections, inflammation or scarring in their lungs. Currently there are no methods to do this accurately. This information will aid them in making decisions about treatment. A new approach to rapidly diagnose lung complications in ICU would enable doctors to target the correct drugs to the appropriate patients and to withdraw drugs with confidence, with resultant improvement in patient outcomes and major cost efficiencies - thus revolutionising ICU care.
Using advanced fibre optic technology and micro-electronics and new sensor arrays our ground-breaking solution is to create a novel fibre-based probe that can readily be passed into the gas exchanging areas of the lung and blood vessels of ICU patients. The probe will house a variety of special optical fibres, some of which allow clinicians to "view" inside the lung while others will be modified with sensors that can measure important parameters such as oxygen concentration and acidity in both blood and lung. In addition the fibre will deliver tiny amounts (microdoses) of 'smart reagents' that fluorescently detect specific bacteria and other agents that can damage the lung. When integrated together these signals will provide highly specific information about the degree or type of lung damage and the potential causative 'bug' if an infection is suspected. Because of the large amount of information generated and in order to make it easily interpreted by doctors, computing experts will convert these signals into easy-to-understand disease readouts for our clinicians.
Work on the different elements needed to create this technology platform will be undertaken by groups of chemists, physicists, engineers, computer scientists and biologists working at Bath, Heriot Watt and Edinburgh universities. Crucially, this programme will bring these scientific disciplines together in a "hub" where they will work side-by-side, promoting integration of purpose and to ensure that advances are rapidly translated into the clinical setting. This interdisciplinary hub will also provide a fertile training base for new PhD students who will learn the cross-disciplinary skills that will equip them to meet the challenges of translating the current 'revolution' in physical sciences into benefit for UK healthcare.
In summary this project will generate; 1) a new cohort of scientists trained in physical and biological science that have a full appreciation of clinical translational and commercialisation pathways and who are equipped to meet the challenges of converting advances in basic science into healthcare benefit and; 2) a cutting-edge bedside technology platform which will help doctors in the ICU make rapid and accurate diagnoses.
Planned Impact
Our proposed research programme will generate numerous avenues for the realisation of impact:
Patients: FOSIP will provide a unique opportunity for clinicians to rapidly monitor key physiological and pathological events simultaneously in the lungs and blood of critically ill patients in 'real time' at the bedside without the need for cumbersome equipment or ionizing radiation. This will permit rapid 'point-of-care diagnosis and informed decision-making in intensive care units. It will also enable patient stratification for 'personalised' new/expensive drug therapy thereby significantly reducing morbidity and mortality. FOSIP would also be readily applicable to other diseased organs accessible to fibrescopes, particularly the genitourinary tract and the upper and lower gastrointestinal tract.
NHS: Although patient numbers in ICUs are comparatively small, the economic burden is disproportionately huge. Rapid and incisive bedside diagnosis, particularly of specific infections or inflammation/scarring processes would lead to stratification of patient care and tailored prescribing patterns, including the use/non-use of expensive and potentially toxic anti-bacterials. Ultimately this would translate into reduced ventilator dependency and reduced mortality and morbidity with a proportionate economic benefit.
UK PLC: UK Healthcare must reap the dividend of the current 'revolution' in physical sciences. This research programme will deliver new leading-edge multi and cross-disciplinary research in exciting and highly translatable areas of optics, imaging, data analysis and chemistry. Our proposed programme is driven by a clear "healthcare pull" from ICU (with application to diseases in other organs); it fits squarely with EPSRC goals in the Healthcare and Life Sciences sector. Enabling activities through our IRC will create a new generation of scientists, engineers and technologists with a translational agenda and mind-set for the benefit of the UK economy.
Training: A central part of our agenda is to break down traditional 'barriers' between physical and biomedical sciences. The PDRA's will benefit immensely from the interdisciplinary, translational thrust of the programme and the cross-fertilisation that will derive from the 'hub' in work package 6. Moreover, through our PhD students specifically engaged in cross-disciplinary projects we will create a new cadre of scientist who are multi-skilled and equipped to meet the challenges of applying new technologies to healthcare provision in the new era. They will gain a wide variety of both "hard and soft" skills that will be readily applied in a variety of employment sectors.
Industry: All the applicants have major interactions with industry, and most have direct personal experience of spin-off/spin-out companies. As the programme progresses new commercial opportunities will undoubtedly arise in fibre technology, engineering, novel chemical probes, image analysis and computing. When the integrative capacity of the programme is realised and FOSIP is applied to human disease and its models, commercialization prospects in the global healthcare arena will be significant.
General: Our multidisciplinary programme will provide many opportunities for involvement in public engagement and dissemination. Research fellows will participate at the International Science Festivals and become involved in a variety of out-reach activities such as the 'Researchers-in-Residence Programme' which places postgraduate students in local secondary schools allowing the public to benefit, as well as engaging the next generation of scientists.
Patients: FOSIP will provide a unique opportunity for clinicians to rapidly monitor key physiological and pathological events simultaneously in the lungs and blood of critically ill patients in 'real time' at the bedside without the need for cumbersome equipment or ionizing radiation. This will permit rapid 'point-of-care diagnosis and informed decision-making in intensive care units. It will also enable patient stratification for 'personalised' new/expensive drug therapy thereby significantly reducing morbidity and mortality. FOSIP would also be readily applicable to other diseased organs accessible to fibrescopes, particularly the genitourinary tract and the upper and lower gastrointestinal tract.
NHS: Although patient numbers in ICUs are comparatively small, the economic burden is disproportionately huge. Rapid and incisive bedside diagnosis, particularly of specific infections or inflammation/scarring processes would lead to stratification of patient care and tailored prescribing patterns, including the use/non-use of expensive and potentially toxic anti-bacterials. Ultimately this would translate into reduced ventilator dependency and reduced mortality and morbidity with a proportionate economic benefit.
UK PLC: UK Healthcare must reap the dividend of the current 'revolution' in physical sciences. This research programme will deliver new leading-edge multi and cross-disciplinary research in exciting and highly translatable areas of optics, imaging, data analysis and chemistry. Our proposed programme is driven by a clear "healthcare pull" from ICU (with application to diseases in other organs); it fits squarely with EPSRC goals in the Healthcare and Life Sciences sector. Enabling activities through our IRC will create a new generation of scientists, engineers and technologists with a translational agenda and mind-set for the benefit of the UK economy.
Training: A central part of our agenda is to break down traditional 'barriers' between physical and biomedical sciences. The PDRA's will benefit immensely from the interdisciplinary, translational thrust of the programme and the cross-fertilisation that will derive from the 'hub' in work package 6. Moreover, through our PhD students specifically engaged in cross-disciplinary projects we will create a new cadre of scientist who are multi-skilled and equipped to meet the challenges of applying new technologies to healthcare provision in the new era. They will gain a wide variety of both "hard and soft" skills that will be readily applied in a variety of employment sectors.
Industry: All the applicants have major interactions with industry, and most have direct personal experience of spin-off/spin-out companies. As the programme progresses new commercial opportunities will undoubtedly arise in fibre technology, engineering, novel chemical probes, image analysis and computing. When the integrative capacity of the programme is realised and FOSIP is applied to human disease and its models, commercialization prospects in the global healthcare arena will be significant.
General: Our multidisciplinary programme will provide many opportunities for involvement in public engagement and dissemination. Research fellows will participate at the International Science Festivals and become involved in a variety of out-reach activities such as the 'Researchers-in-Residence Programme' which places postgraduate students in local secondary schools allowing the public to benefit, as well as engaging the next generation of scientists.
Organisations
- University of Edinburgh (Lead Research Organisation)
- DURHAM UNIVERSITY (Collaboration)
- University of Bath (Collaboration)
- Heriot-Watt University (Collaboration)
- BTG (Collaboration)
- Renishaw (United Kingdom) (Collaboration)
- UNIVERSITY OF DUNDEE (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
Publications
Kufcsák A
(2017)
Time-resolved spectroscopy at 19,000 lines per second using a CMOS SPAD line array enables advanced biophotonics applications.
in Optics express
Tye CS
(2024)
Photon counting fibre optic distributed temperature sensing with a CMOS SPAD array.
in Optics express
Krstajic N
(2015)
256 × 2 SPAD line sensor for time resolved fluorescence spectroscopy.
in Optics express
Ehrlich K
(2017)
pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays.
in Optics express
Wood H.A.C.
(2016)
Quantitative characterisation of endoscopic imaging fibres
in Optics InfoBase Conference Papers
Stone J
(2014)
Highly birefringent 98-core fiber
in Optics Letters
Kamaljith V
(2020)
Ultrafast-laser-ablation-assisted spatially selective attachment of fluorescent sensors onto optical fibers.
in Optics letters
Rocca FM
(2016)
Real-time fluorescence lifetime actuation for cell sorting using a CMOS SPAD silicon photomultiplier.
in Optics letters
Krstajic N
(2015)
0.5 billion events per second time correlated single photon counting using CMOS SPAD arrays.
in Optics letters
Mai H
(2023)
Development of a high-speed line-scanning fluorescence lifetime imaging microscope for biological imaging.
in Optics letters
Title | PROTEUS ART EXHIBITION |
Description | Ron O'Donnell - Photographs |
Type Of Art | Artwork |
Year Produced | 2015 |
Impact | • Proteus Art Exhibition - Introducing Proteus science through contemporary art. (Edinburgh/China) March 2015/ June 2015 Audience: Wider members of the public, academics, patients Engagement methods: Working with a contemporary artist to create portraits of our researchers which allowed dialogue about the specifics of their science research. Impact: High level of interest - changed hearts and minds in terms of who our scientists are and what the science can achieve- reflected in a questionnaire- high levels of satisfaction and desire to learn more. Event in China as sparked interest in examining how science communication can grow and become established in the Chinese culture - work still on going. |
Title | S1.mp4 |
Description | 10 FPS movie from ex vivo lung tissue taken in in non time-resolved modality using the APD detector. Some monocyte cells labeled with Calcein are visible in the foreground. The image intensity represents the voltage output of the APD. |
Type Of Art | Film/Video/Animation |
Year Produced | 2018 |
URL | https://opticapublishing.figshare.com/articles/media/S1_mp4/7455056/1 |
Title | Visualisation 1 2742068.mp4 |
Description | Compilation of subsequent visualisations. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_1_2742068_mp4/5260246/1 |
Title | Visualisation 1 2742068.mp4 |
Description | Compilation of subsequent visualisations. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_1_2742068_mp4/5260246 |
Title | Visualisation 1.mp4 |
Description | Ratiometric fibre-based fluorescent imaging of lung tissue |
Type Of Art | Film/Video/Animation |
Year Produced | 2019 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_1_mp4/7454603 |
Title | Visualisation 1.mp4 |
Description | Ratiometric fibre-based fluorescent imaging of lung tissue |
Type Of Art | Film/Video/Animation |
Year Produced | 2019 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_1_mp4/7454603/1 |
Title | Visualisation 2 - Fig2.mp4 |
Description | Observation of 'light in flight' through an optical fibre. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_2_-_Fig2_mp4/5249290/1 |
Title | Visualisation 2 - Fig2.mp4 |
Description | Observation of 'light in flight' through an optical fibre. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_2_-_Fig2_mp4/5249290 |
Title | Visualisation 2.mp4 |
Description | Ratiometric fibre-based imaging of lung tissue and fluorescently labelled bacteria |
Type Of Art | Film/Video/Animation |
Year Produced | 2019 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_2_mp4/7454615 |
Title | Visualisation 2.mp4 |
Description | Ratiometric fibre-based imaging of lung tissue and fluorescently labelled bacteria |
Type Of Art | Film/Video/Animation |
Year Produced | 2019 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_2_mp4/7454615/1 |
Title | Visualisation 3 - Fig3.mp4 |
Description | Laser pulse scattering through a uniform colloidal suspension (milk). |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_3_-_Fig3_mp4/5249299 |
Title | Visualisation 3 - Fig3.mp4 |
Description | Laser pulse scattering through a uniform colloidal suspension (milk). |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_3_-_Fig3_mp4/5249299/1 |
Title | Visualisation 4 -Fig4.mp4 |
Description | Fibre location in tissue models, a whole avian (chicken) model and an ovine lung with rib cage. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_4_-Fig4_mp4/5249293 |
Title | Visualisation 4 -Fig4.mp4 |
Description | Fibre location in tissue models, a whole avian (chicken) model and an ovine lung with rib cage. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_4_-Fig4_mp4/5249293/1 |
Title | Visualisation 5 - Fig5.mp4 |
Description | Fibre location in a ventilated and perfused ovine lung model with the camera on a tripod over the 'patient'. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_5_-_Fig5_mp4/5249287/1 |
Title | Visualisation 5 - Fig5.mp4 |
Description | Fibre location in a ventilated and perfused ovine lung model with the camera on a tripod over the 'patient'. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_5_-_Fig5_mp4/5249287 |
Title | Visualisation 6 - Fig6.mp4 |
Description | Fibre location through the human body. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_6_-_Fig6_mp4/5249296/1 |
Title | Visualisation 6 - Fig6.mp4 |
Description | Fibre location through the human body. |
Type Of Art | Film/Video/Animation |
Year Produced | 2017 |
URL | https://opticapublishing.figshare.com/articles/media/Visualisation_6_-_Fig6_mp4/5249296 |
Title | Visualization1.mp4 |
Description | A video of automated emission of light from 91 points in a multicore fibre. The pitch of the emission points is 1 cm. The automated coupling is achieved using a laser coupled 2D Galvo-mirror system. |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
URL | https://opticapublishing.figshare.com/articles/media/Visualization1_mp4/14192882/1 |
Title | Visualization1.mp4 |
Description | A video of automated emission of light from 91 points in a multicore fibre. The pitch of the emission points is 1 cm. The automated coupling is achieved using a laser coupled 2D Galvo-mirror system. |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
URL | https://opticapublishing.figshare.com/articles/media/Visualization1_mp4/14192882 |
Title | Visualization2.mp4 |
Description | Different side image intensity distributions in one coupling condition for an emission point. Light is coupled to one emission point and images of the ping-pong ball is taken at different angles with respect to the emission point. |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
URL | https://opticapublishing.figshare.com/articles/media/Visualization2_mp4/14192903/1 |
Title | Visualization2.mp4 |
Description | Different side image intensity distributions in one coupling condition for an emission point. Light is coupled to one emission point and images of the ping-pong ball is taken at different angles with respect to the emission point. |
Type Of Art | Film/Video/Animation |
Year Produced | 2021 |
URL | https://opticapublishing.figshare.com/articles/media/Visualization2_mp4/14192903 |
Title | • Proteus Science Ceilidh: Smart Probes Light Up Science Ceilidh |
Description | • Proteus Science Ceilidh: Smart Probes Light Up Science Ceilidh (Edinburgh) December 2015 Audience: Wider members of the public (adult audience) Engagement methods: Dance and Music (using the arts to explain Smart Probe science) Impact: Increased public's appetite for more creative science engagement - learning through fun and accessible methods. More hits on Proteus website/Social Media post event. Feedback suggested participants would attend a similar event. |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2015 |
Impact | • Proteus Science Ceilidh: Smart Probes Light Up Science Ceilidh (Edinburgh) December 2015 Audience: Wider members of the public (adult audience) Engagement methods: Dance and Music (using the arts to explain Smart Probe science) Impact: Increased public's appetite for more creative science engagement - learning through fun and accessible methods. More hits on Proteus website/Social Media post event. Feedback suggested participants would attend a similar event. |
Description | New world-leading fibres for imaging and sensing - including disposable imaging fibre, Raman fibre (background free), flexible imaging fibres. New world-leading CMSO SPAD detectors and their integration into systems that are entering clinic to allow a whole new dimension in optical medical imaging. New world-leading chemical probes and their in-human use - for cancer margins and fibrosis and bacteria. Major collaborations with industry to develop and push the technology in the area of cancer imaging/detection. Highly trained staff - that are much in demand. Two PDRA's have won fellowships/gained fully independent academic positions. |
Exploitation Route | 12 Patents filed and we are looking to explore these in spinout ventures and in collaboration with various companies. Detectors are being used in a number of different programmes. Smart probes are being used in several different imaging scenarios Some elements have gone into clinic and being used together and combined for clinical studies - with Phase-I studies on going. |
Sectors | Healthcare |
URL | http://www.proteus.ac.uk |
Description | EPSRC Our Health is a "A model of community-based engagement and has presented as an example of best practice in engaged- community based research. We have had a perminant exhibit in the Glasgow science centre, presented out work in the Science Museum in London and presented at the AAAS. We have embed Proteus Circuits! tools into Scottish curriculum to teach 12/13 year old students about bioengineering and its applications around health and wellbeing. Science and the Parliament (Edinburgh) November 2016 Audience: MPs, Senior Academics, Industry, Healthcare Professionals Engagement methods: Hands on demonstrations, videos, written materials Impact: Raise awareness of Proteus Science Interview for national news, Patient group workshop) - The International Edinburgh Book Festival - EPSRC Proteus/ EPSRC Our Health |
Sector | Chemicals,Education,Healthcare,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology |
Impact Types | Cultural Societal Policy & public services |
Description | American Association for the Advancement of Science Meeting 2018 - Invited to the meeting as a Flagship EPSRC project representing UK science on the main exhibition stage as well as the International Reception. Engagement Methods -Proteus Digital Lung Game - Designed by Proteus team in collaboration with Glasgow Science Centre. Impact: Raised awareness of EPSRC Proteus with UKRI CEO and wider RIUK team. Networked with senior academics, policy makers and US industries. Received media coverage for the project from the BBC. |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Impact: Raised awareness of EPSRC Proteus with UKRI CEO and wider RIUK team. Engaged with senior academics, policy makers and US industries and wider public. Received media coverage for the project from the BBC. |
URL | http://www.bbc.co.uk/news/science-environment-43076783 |
Description | Awarded The Royal Academy of Engineering Ingenious Grant - (Audience: Scottish Schools (students and teachers) and Research Centre for Teachers continuous Development. Engagement methods: Education tools that describe Proteus biomedical research. Impact: Embed Proteus Circuits! tools into Scottish curriculum to teach 12/13 year old students about bioengineering and its applications around health and wellbeing. |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Inspire Students to consider STEM subjects and careers. Teach students about biomedical engineering in new engaging ways. bridge gaps between high school teachers and university research. Empower teachers to teach students about cutting edge research. Provide training and skills for researchers to engage widely and with confidence and expertise. |
URL | https://proteus.ac.uk/public-engagement/ingenious/our-project-circuits/ |
Description | House of Lords Science and Technology Committee |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
URL | http://www.parliamentlive.tv/Event/Index/3a9d05fd-a47f-411f-8173-5d99a1d53327 |
Description | Proteus Showcase Event (Edinburgh) October 2014 - Note none of the options allowed below fit ! An open text box would be more useful ! |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | The Royal Society of Edinburgh AMR (Antimicrobial Resistance) October 2014 |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | -- |
Description | • ICU Engagement Event February 2016 Audience: NHS ICU staff Engagement methods: Hands on demonstrations, posters, written materials Impact: Raise awareness of Proteus Science to end users - strengthened engagement, created possibilities for ongoing dialogue. • ICU Research Nurses Event February 2018 Audience: NHS ICU Research nurses Engagement methods: Hands on demonstrations, posters, written materials Impact: Raise awareness of Proteus Science to research nurses who may use Proteus technology. Introduced nurses to members of the Proteus team, strengthen engagement and interdisciplinary work. |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | -- |
Description | • Public and Patient Involvement - Funding Award Received from ACCORD February 2018 Audience: Respiratory Patients (Breathtakers and Breatheasy) Engagement methods: Dialogue sessions with patients, creative story telling workshops Impact: Creation of Proteus research pod at Glasgow science. Work ongoing to develop pilot studies for patient engagement using the Proteus interdisciplinarity model as an engagement framework. |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | -- |
Description | • Science and the Parliament (Edinburgh) November 2016 Audience: MPs, Senior Academics, Industry, Healthcare Professionals Engagement methods: Hands on demonstrations, videos, written materials Impact: Raise awareness of Proteus Science, forged a link with Scottish Chief Medical Officer - arranged meeting to visit Proteus labs post event. |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Description | Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis |
Amount | € 4,400,000 (EUR) |
Funding ID | 825931 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2020 |
End | 12/2022 |
Description | EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond |
Amount | £3,852,991 (GBP) |
Funding ID | EP/R005257/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2019 |
End | 12/2023 |
Description | IRC Next Steps Plus: Photonic Pathogen Theranostics - Point-of-care image guided photonic therapy of bacterial and fungal infection |
Amount | £1,100,000 (GBP) |
Funding ID | EP/R018669/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2019 |
End | 03/2022 |
Description | IRC Next steps funding |
Amount | £3,900,000 (GBP) |
Funding ID | EP/R005257/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2019 |
End | 02/2023 |
Description | MRC CiC (none of the options below re grant type are right/suitable as it is a confidence in concept grant) |
Amount | £700,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 02/2020 |
Description | Multi-modal Manufacturing of Medical Devices (4MD) |
Amount | £1,302,969 (GBP) |
Funding ID | EP/P027415/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2017 |
End | 07/2023 |
Description | Next generation endoscopes |
Amount | £981,162 (GBP) |
Funding ID | EP/S001123/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2018 |
End | 06/2022 |
Description | Next-Generation Sensing For Human In Vivo Pharmacology- Accelerating Drug Development In Inflammatory Diseases |
Amount | £1,463,801 (GBP) |
Funding ID | EP/S025987/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2019 |
End | 04/2023 |
Description | Single Photons - Expanding the Spectrum (SPEXS) |
Amount | £5,265,567 (GBP) |
Funding ID | EP/S026428/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2020 |
End | 09/2025 |
Description | Through-body TCSPC based real-time tracking to guide interventional medical procedures |
Amount | £315,108 (GBP) |
Funding ID | ST/S000763/1 |
Organisation | Science and Technologies Facilities Council (STFC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 03/2022 |
Description | WT/CARB-X (none of the "type of funding" given below are really suitable) |
Amount | £2,500,000 (GBP) |
Funding ID | 208608/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2017 |
End | 12/2022 |
Title | Fluorescent life-time video rate CMOS SPAD detectors |
Description | Fluorescent life-time video rate CMOS SPAD detectors have been developed across the team. They are being evaluated by other groups and organisations in a number of scenarios. There is no a spinout that is pursuing these detectors and the new capabilities developed during the next steps project. |
Type Of Material | Technology assay or reagent |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | Possible use in analysis of histology samples, real-time detection of cancer margins etc.. rapid life-time microscopy. |
Title | Data for "High resolution air-clad imaging fibers" |
Description | The data supporting the results presented in the paper "High resolution air-clad imaging fibers". This body of work is designed to provide an indication of the imaging performance of a novel, high resolution imaging coherent fibre bundle fabricated in the University of Bath's Centre for Photonics and Photonic Materials' facilities. Traditionally, the imaging fibres such as those used in medical endoscopes consist of solid doped and undoped silica glass. The novelty of our design is in having the cladding that is comprised of air-filled silica capillaries, achieving a cladding index close to that of air. This increase in index contrast with the cores (still solid doped silica) provides a higher numerical aperture waveguide. As a result, the light is better confined to the cores, and higher resolution, or a wider operational bandwidth, can be achieved. |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Title | Data for Quantitative characterisation of imaging fibres |
Description | Images, code and data used to produce the figures in the paper Quantitative characterisation of imaging fibres. |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Title | Data for the publication: Low index contrast imaging fibers |
Description | This contains the images and raw data presented in the paper Low index contrast imaging fibres published in Optics Letters. The data includes the individual images used to demonstrate how the new fibres are made and the raw data used to determine the performance of the imaging fibres presented in the publication. |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Title | Dataset for "Birefringent Anti-resonant Hollow-core Fiber" |
Description | This dataset contains data supporting the results presented in the paper "Birefringent Anti-resonant Hollow-core Fiber" and the supplementary material. It includes the data used to plot each figure (in .xlsx format), together with simulated data obtained using COMSOL. Hollow-core fibres have demonstrated record performance in applications such as high-power pulse delivery, quantum computing, and sensing. However, their routine use is yet to become reality. A major obstacle is the ability to maintain the polarisation state of light over a broad range of wavelengths, while also ensuring single-mode guidance and attenuation that is low enough for practical applications that require only a few meters of fibre length (<1 dB/m). Here we simulated, fabricated and characterized a single-mode birefringent anti-resonant hollow-core fibre. The birefringence was achieved by introducing capillary tubes of different thicknesses, thereby creating reduced symmetry in the structure. The measured group birefringence is in good agreement with the calculated group birefringence from simulations across the fibre guidance band within the telecommunications C-band. At 1550 nm, we measured a group birefringence of 4.4E-5, which corresponds to a phase birefringence of 2.5E-5. The measured loss of the fibre was 0.46 dB/m at 1550 nm. The measured polarisation extinction ratio of the fibre at 1550 nm was 23.1 dB (25.7 dB) along the x-(y-) polarisation axis, relating to an h-parameter of 9.8E-4 (5.3E-4). |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://researchdata.bath.ac.uk/id/eprint/767 |
Title | Dataset for Ultra-low background Raman sensing using a negative-curvature fibre and no distal optics |
Description | Collected data for the results presented in "Ultra-low background Raman sensing using a negative-curvature fibre and no distal optics" demonstrating the use of a single hollow core negative curvature fibre for Raman and surface enhanced Raman spectroscopy sensing. This new optical fibre shows a 1000x background reduction compared to conventional fibres while maintaining the same collection efficiency. The dataset includes Raman and SERS spectra from different samples and attenuation data for a range of wavelengths for the negative curvature fibre. |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Description | Collaboration with BTG (Boston Scientific) |
Organisation | BTG |
Country | United Kingdom |
Sector | Private |
PI Contribution | Use of Proteus imaging technology and hardware re cancer analysis and ablation |
Collaborator Contribution | cryo ablation system and design skills and expertise |
Impact | Confidential |
Start Year | 2018 |
Description | Collaboration with Dundee Univ |
Organisation | University of Dundee |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaboration, mentorship and supervision |
Collaborator Contribution | Collaboration, mentorship and supervision |
Impact | Activities on going |
Start Year | 2019 |
Description | Collaboration with industrial partners |
Organisation | Renishaw PLC |
Department | Renishaw Diagnostics Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Detectors or Raman |
Collaborator Contribution | Use of the detectors |
Impact | Confidential Multi-disiplionary |
Start Year | 2019 |
Description | Collaboration with multiple univ partners |
Organisation | Durham University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New detector designs and systems |
Collaborator Contribution | expertise and skills in the area of optical design |
Impact | Collaboration in new grants and new grant submissions. Collaboration is inter-disciplinary |
Start Year | 2017 |
Description | Collaborations with multiple universities |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Detectors and software |
Collaborator Contribution | Use in histology analysis |
Impact | use of our detectors to support new applications and uses |
Start Year | 2019 |
Description | Ra-II Detectors being used in other areas |
Organisation | University of Southampton |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | provision of Ra-II Detectors |
Collaborator Contribution | Dual modalities in imaging |
Impact | Too early |
Start Year | 2021 |
Description | This is an IRC - it is by definition a collaboration |
Organisation | Durham University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath. |
Collaborator Contribution | Massive collaborations (please see the web site www.proteus.ac.uk) |
Impact | Please see list of publications/patents/engagement activities on the Proteus web site. |
Start Year | 2013 |
Description | This is an IRC - it is by definition a collaboration |
Organisation | Heriot-Watt University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath. |
Collaborator Contribution | Massive collaborations (please see the web site www.proteus.ac.uk) |
Impact | Please see list of publications/patents/engagement activities on the Proteus web site. |
Start Year | 2013 |
Description | This is an IRC - it is by definition a collaboration |
Organisation | University of Bath |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath. |
Collaborator Contribution | Massive collaborations (please see the web site www.proteus.ac.uk) |
Impact | Please see list of publications/patents/engagement activities on the Proteus web site. |
Start Year | 2013 |
Description | This is an IRC - it is by definition a collaboration |
Organisation | University of Dundee |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath. |
Collaborator Contribution | Massive collaborations (please see the web site www.proteus.ac.uk) |
Impact | Please see list of publications/patents/engagement activities on the Proteus web site. |
Start Year | 2013 |
Title | A SENSING STRUCTURE AND METHOD OF FORMING A SENSING STRUCTURE |
Description | A method for forming a sensing structure on a distal end of a multicore optical fibre, the method comprises contacting at least part of the distal end of the multicore optical fibre with a polymerisation material, coupling light from a light source to a proximal end of a selected one of the cores of the multicore optical fibre, and photo-polymerising, using the light from the light source transmitted through the selected core, a region of the polymerisation material adjacent to a distal face of the selected core to form said sensing structure such that the sensing structure substantially does not overlap any of the other cores of the multicore optical fibre. |
IP Reference | WO2017203272 |
Protection | Patent application published |
Year Protection Granted | 2017 |
Licensed | Commercial In Confidence |
Impact | Confidential |
Title | ENDOSCOPIC IMAGING APPARATUS AND METHOD |
Description | An endoscopic imaging apparatus comprises at least one light source (1, 2, 3) configured to provide excitation signals to an imaging region via a common transmission path. Each excitation signal has one of a plurality of different colours. A controller (100) is configured to control the at least one light source (1, 2, 3) to provide the excitation signals as a repeating time-interleaved sequence that comprises at least an excitation signal of a first one of the colours and a subsequent excitation signal of a second one of the colours. A monochrome detector (80) is configured, for each of at least some of the excitation signals, to receive at least part of a respective response signal emitted from the imaging region in response to the excitation signal and to generate image data based on the at least part of the response signal. |
IP Reference | WO2017174998 |
Protection | Patent application published |
Year Protection Granted | 2017 |
Licensed | Commercial In Confidence |
Impact | Confidentail |
Title | FRAME SELECTION IN MEDICAL IMAGE DATA |
Description | A method comprises receiving a sequence of frames comprising optical endomicroscopy image data, determining for each frame in the sequence of frames a value of at least one image measure, for each frame in the sequence of frames, determining based on said value of the at least one image measure whether the frame meets a criterion, thereby to select a plurality of frames of the frame sequence, and providing an output representative of the selected plurality of frames for display. |
IP Reference | WO2017149310 |
Protection | Patent application published |
Year Protection Granted | 2017 |
Licensed | Commercial In Confidence |
Impact | Confidential |
Title | OPTICAL PROBES FOR MATRIX METALLOPROTEINASES |
Description | An optical probe is presented comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the or each fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence;the or each fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of the at least one probe element is cleaved; and the enzyme cleavable peptide sequence is selectively cleavable by one or more matrix metalloproteinase (MMP). Methods of use of the optical probe are also presented. |
IP Reference | WO2016151299 |
Protection | Patent application published |
Year Protection Granted | 2016 |
Licensed | Commercial In Confidence |
Impact | confidential |
Title | OPTICAL SYSTEM AND METHOD |
Description | A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light. |
IP Reference | WO2018203088 |
Protection | Patent application published |
Year Protection Granted | 2018 |
Licensed | Commercial In Confidence |
Impact | Confidential |
Title | Photon Sensor Apparatus |
Description | A sensor apparatus for photon sensing comprises a plurality of pixel devices, each pixel device comprising: a plurality of photon detectors arranged to produce photon detection signals in response to photon detection events; a processing resource configured to process photon detection signals to produce photon detection event signals, wherein each photon detection event signal comprises time data representative of a photon detection time at which a respective photon detection event occurred; a pixel memory; a further processing resource configured to process the photon detection event signals to obtain detection data representative of photon detection events over a detection period; a communication resource for transmitting the detection data from the pixel device, wherein the processing of the photon detection event signals is such that storing and/or transmission of the detection data uses less storage capacity and/or communication capacity than would be used by storage and/or transmission of the photon detection event signals directly. |
IP Reference | US2020116838 |
Protection | Patent / Patent application |
Year Protection Granted | 2020 |
Licensed | Yes |
Impact | Spinout SENSE PHOTONICS INC pursuing multiple angles and commercialisation with additional patent filings. |
Title | SERS PROBE COMPRISING A DUAL-CORE OPTICAL FIBER AND A SPACER ONTO WHICH SERS-ACTIVE NANOPARTICLES ARE ATTACHED |
Description | A spectroscopy probe apparatus comprising an excitation path configured to transmit excitation light for exciting a response; a collection path different from the excitation path and configured to transmit signal light comprising a response signal, wherein at least one of the excitation path or collection path comprises or is formed in at least one optical fibre; and a light guide having a proximal end coupled to the excitation path and to the collection path, wherein the guide is configured to pass the excitation light from the excitation path to a target region to generate the response signal, and to pass the signal light comprising the response signal from the target region to the collection path. |
IP Reference | WO2017158331 |
Protection | Patent application published |
Year Protection Granted | 2017 |
Licensed | Commercial In Confidence |
Impact | Confidential |
Title | Bac-II |
Description | Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC TWO. BAC TWO will be instilled directly into the lungs of 12 patients to assess whether it can label gram-negative bacteria in the human lung. |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2016 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC TWO. BAC TWO will be instilled directly into the lungs of 12 patients to assess whether it can label gram-negative bacteria in the human lung. |
URL | https://clinicaltrials.gov/ct2/show/NCT02491164?term=NCT02491164&rank=1 |
Title | Exploratory clinical study of intrapulmonary microdosing of the BACterial detection probe (BAC ONE) |
Description | Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC ONE. BAC ONE will be instilled directly into the lungs of 12 patients (with and without lung infection) to assess whether it can label bacteria in the human lung. |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2018 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC ONE. BAC ONE will be instilled directly into the lungs of 12 patients (with and without lung infection) to assess whether it can label bacteria in the human lung. |
URL | https://clinicaltrials.gov/ct2/show/NCT02558062?term=NCT02558062&rank=1 |
Title | FIB-ONE |
Description | Brief Summary: While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function. In other words, affected 'fibrotic' tissues are unable to heal back to normal and therefore don't work as effectively as they normally would. In the case of the lung, fibrosis can occur across large parts of the lung such as in conditions like Idiopathic Pulmonary Fibrosis (IPF) and sarcoidosis or it can occur in much smaller patches such as around the borders of some lung tumours. At the moment the investigators don't fully understand the mechanisms of fibrosis and so therefore cannot monitor or treat these conditions as effectively as the investigators could. Despite the significant global financial burden of these diseases, treatment options are very limited and monitoring of disease progression remains a real challenge. In an effort to address this problem, the research team have designed and synthesised an imaging agent (FIB ONE) that can detect fibrosis in the lung. FIB ONE will be used at very low concentrations in patients with a lung condition characterised by excessive activity of the fibroproliferative pathway either scheduled for a routine bronchoscopy or elective surgery. FIB ONE will be administered directly into the lungs during a bronchoscopy procedure and images of the lungs will be analysed. As part of this study, the research team's novel endomicroscopy detection system will be compared to equipment that is routinely used in the NHS when imaging the FIB ONE probe. |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2017 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Brief Summary: While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function. In other words, affected 'fibrotic' tissues are unable to heal back to normal and therefore don't work as effectively as they normally would. In the case of the lung, fibrosis can occur across large parts of the lung such as in conditions like Idiopathic Pulmonary Fibrosis (IPF) and sarcoidosis or it can occur in much smaller patches such as around the borders of some lung tumours. At the moment the investigators don't fully understand the mechanisms of fibrosis and so therefore cannot monitor or treat these conditions as effectively as the investigators could. Despite the significant global financial burden of these diseases, treatment options are very limited and monitoring of disease progression remains a real challenge. In an effort to address this problem, the research team have designed and synthesised an imaging agent (FIB ONE) that can detect fibrosis in the lung. FIB ONE will be used at very low concentrations in patients with a lung condition characterised by excessive activity of the fibroproliferative pathway either scheduled for a routine bronchoscopy or elective surgery. FIB ONE will be administered directly into the lungs during a bronchoscopy procedure and images of the lungs will be analysed. As part of this study, the research team's novel endomicroscopy detection system will be compared to equipment that is routinely used in the NHS when imaging the FIB ONE probe. |
URL | https://clinicaltrials.gov/ct2/show/NCT02604862?term=NCT02604862&rank=1 |
Description | AAAS Meeting 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | AAAS Meeting 2019 - Invited to the meeting as a Flagship EPSRC project representing UK science on the main exhibition stage as well as the International Reception. Feb 2019 Audience: American Academics, Members of Congress, American Industries, RIUK team lead by Sir Mark Walport (CEO) World Media Teams, Global stakeholders (academics, policy makers) students and wider publics Engagement methods: Proteus Technology Versicolour Impact: Raised awareness of EPSRC Proteus with UKRI CEO and wider RIUK team. Networked with senior academics, policy makers and US industries. Created new collaborations with industrial partners |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.ukri.org/aaas/ |
Description | Development of an ICU Patient and Public Involvement Group |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Public and Patient Involvement -I CU PPI GROUP March 2018 Audience: ICU Patients and families Engagement methods: Dialogue sessions with patients, partnership building activities, developing PPI projects Impact: Creation of Edinburgh's first ICU PPI group, working with the Critical Care Team in Edinburgh and nationally with ICU Steps - has allowed ICU patients to take part in Proteus engagement activities and has strengthen Proteus' PPI portfolio |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.ed.ac.uk/clinical-sciences/divisionpgdi/anaesthesia/news-views/icusteps-patient-and-fami... |
Description | EPSRC Our Health - Dr Henk Mulder Visit (Science Shop Expert, The University of Groningen) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | EPSRC Our Health - Dr Henk Mulder Visit (Science Shop Expert, The University of Groningen) April 2018 Audience: Local community, patient groups, undergraduates/postgraduates, academics and Public Engagement Professionals Engagement methods: Presentation and workshop Impact: Dr Henk Mulder's visit for part of a University wide consultation around the Science Shop model for community/patient engagement and resulted in the funding and launch of Our Health |
Year(s) Of Engagement Activity | 2018 |
Description | EPSRC Our Health - The First UK Interdisciplinary Science Shop |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | EPSRC Our Health - The First UK Interdisciplinary Science Shop June 2018 Audience: Local community, patient groups, undergraduates/postgraduates, academics and Public Engagement professionals Engagement methods: Community based research projects around Health and well being Impact: EPSRC Our Health (within first 6 months of launch) has created national and international impact. Our Health was selected to host the Experienced Practice Learning Exchange for international delegates as part of The National Co ordinating Centre's National ENGAGE 2018 Conference. EPSRC Our Health has also been asked to work in partnership with UKRI International PE team to develop global projects for Our Health. Our Health has impacted the local community by creating new knowledge around health and well being with community partners. |
Year(s) Of Engagement Activity | 2018 |
URL | https://proteus.ac.uk/public-engagement/developing-community-partnerships/our-health/about-our-healt... |
Description | Living Knowledge 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Living Knowledge 2018 - Invited as a speaker to the Living Knowledge Confrenec (Budapest) to present EPSRC Our Health and share best practice around this new Interdisciplinary model of a science shop July 2018 Audience: International Public Engagement Delegates and Community partners Engagement methods: Workshops, presentations and visits to local communities to talk with people about their involvement in PE. Impact: EPSRC Our Health is now established with in the European community and is part of a wider network and a leader in the field of interdisciplinary community research |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.livingknowledge.org/lk8/ |
Description | Proteus Partnership with Msc Science Communication Programme |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Proteus Partnership with Msc Science Communication Programme 2018 Audience: Eight Science Communication Master Students work with Proteus each year engaging wider publics and community partners. Engagement methods: science writing, activity based presentations, dialogic workshops and creative co inquiry. Impact: developed a community of public engagement practice throughout the university and with local universities. Sharing of best practice, improving quality and impact of public engagement work. Work created by students have promoted and raised the profile of Proteus across a wide range of project stakeholders. |
Year(s) Of Engagement Activity | 2018 |
Description | Proteus Public Engagement (PE) Strategic Influence |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Proteus Public Engagement (PE) Strategic Influence - Proteus represented at the Strategic PE Group, The University of Edinburgh March 2018 Audience: Senior colleagues working within PE and members of the wider public, The University of Edinburgh (UoE) Engagement methods: Committee discussions, development of UoE PE strategy Impact: Proteus PE influences the strategic direction of PE for The University of Edinburgh |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.ed.ac.uk/institute-academic-development/research-roles/public-engagement/pe-strategy |
Description | Science at Heriot Watt 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Science at Heriot Watt 2018 (Heriot Watt University) April 2018 Audience: Wider Public Engagement methods: Hands on demonstrations, activities and storytelling Impact: Raise awareness of Proteus Science with family audience. Strengthened links with Heriot Watt University. |
Year(s) Of Engagement Activity | 2018 |
Description | The Edinburgh International Science Festival (Edinburgh) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | The Edinburgh International Science Festival (Edinburgh) April 2018 Audience: Wider Public Engagement methods: Hands on demonstrations, activities and storytelling Impact: Raised awareness of Proteus Science with family audiences. Created interest amongst researcher working in infectious diseases in Roslin centre - formed new collaboration with Dr Kenneth Ballie around PE activities |
Year(s) Of Engagement Activity | 2018 |
Description | The International Edinburgh Book Festival - EPSRC Proteus/ EPSRC Our Health |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | The International Edinburgh Book Festival August 2018 Audience: Wider Public Engagement methods: Hands on demonstrations and research art exhibition. Our Health students and community partners formed a choir and sang. Impact: Principal of The University of Edinburgh attended and gave strong support for Proteus/Our Health. As a consequence of this event the The University of Edinburgh, Proteus/Our Health and The International Edinburgh Book Festival have agreed to work together on further PE activities |
Year(s) Of Engagement Activity | 2018 |
Description | UKRI Festival of Tomorrow |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | UKRI Festival of Tomorrow - to showcase EPSRC-UKRI research. Created a virtual booth for public audience to view aspects of IRC Proteus research. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.scienceswindon.com/festival-of-tomorrow |