Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry

Abstract

This project is all about multi-disciplinary collaboration - and capitalisation in a clinical setting of the many new vistas and opportunities that will arise. As such this research programme brings together a group of world class scientists (physicists, chemists, engineers and computer experts) and clinicians to design, make and test a cutting-edge bedside technology platform which will help doctors in the intensive care unit (ICU) make rapid and accurate diagnoses that would inform therapy and ensure patients get the right treatment, quickly. While we are developing our technology platform with a focus on ICU, it will also be applicable to a wide range of other healthcare situations.

ICU patients suffer high death and disability rates and are responsible for a disproportionate financial burden on the health service. Potentially fatal lung complications are a common problem in ventilated ICU patients and doctors caring for these patients in the ICU face many challenges, often needing to make snap decisions without the information necessary to properly inform those decisions. The technology platform developed in this programme will provide doctors with important information on the state of ICU patients and whether they have infections, inflammation or scarring in their lungs. Currently there are no methods to do this accurately. This information will aid them in making decisions about treatment. A new approach to rapidly diagnose lung complications in ICU would enable doctors to target the correct drugs to the appropriate patients and to withdraw drugs with confidence, with resultant improvement in patient outcomes and major cost efficiencies - thus revolutionising ICU care.

Using advanced fibre optic technology and micro-electronics and new sensor arrays our ground-breaking solution is to create a novel fibre-based probe that can readily be passed into the gas exchanging areas of the lung and blood vessels of ICU patients. The probe will house a variety of special optical fibres, some of which allow clinicians to "view" inside the lung while others will be modified with sensors that can measure important parameters such as oxygen concentration and acidity in both blood and lung. In addition the fibre will deliver tiny amounts (microdoses) of 'smart reagents' that fluorescently detect specific bacteria and other agents that can damage the lung. When integrated together these signals will provide highly specific information about the degree or type of lung damage and the potential causative 'bug' if an infection is suspected. Because of the large amount of information generated and in order to make it easily interpreted by doctors, computing experts will convert these signals into easy-to-understand disease readouts for our clinicians.

Work on the different elements needed to create this technology platform will be undertaken by groups of chemists, physicists, engineers, computer scientists and biologists working at Bath, Heriot Watt and Edinburgh universities. Crucially, this programme will bring these scientific disciplines together in a "hub" where they will work side-by-side, promoting integration of purpose and to ensure that advances are rapidly translated into the clinical setting. This interdisciplinary hub will also provide a fertile training base for new PhD students who will learn the cross-disciplinary skills that will equip them to meet the challenges of translating the current 'revolution' in physical sciences into benefit for UK healthcare.

In summary this project will generate; 1) a new cohort of scientists trained in physical and biological science that have a full appreciation of clinical translational and commercialisation pathways and who are equipped to meet the challenges of converting advances in basic science into healthcare benefit and; 2) a cutting-edge bedside technology platform which will help doctors in the ICU make rapid and accurate diagnoses.

Planned Impact

Our proposed research programme will generate numerous avenues for the realisation of impact:

Patients: FOSIP will provide a unique opportunity for clinicians to rapidly monitor key physiological and pathological events simultaneously in the lungs and blood of critically ill patients in 'real time' at the bedside without the need for cumbersome equipment or ionizing radiation. This will permit rapid 'point-of-care diagnosis and informed decision-making in intensive care units. It will also enable patient stratification for 'personalised' new/expensive drug therapy thereby significantly reducing morbidity and mortality. FOSIP would also be readily applicable to other diseased organs accessible to fibrescopes, particularly the genitourinary tract and the upper and lower gastrointestinal tract.

NHS: Although patient numbers in ICUs are comparatively small, the economic burden is disproportionately huge. Rapid and incisive bedside diagnosis, particularly of specific infections or inflammation/scarring processes would lead to stratification of patient care and tailored prescribing patterns, including the use/non-use of expensive and potentially toxic anti-bacterials. Ultimately this would translate into reduced ventilator dependency and reduced mortality and morbidity with a proportionate economic benefit.

UK PLC: UK Healthcare must reap the dividend of the current 'revolution' in physical sciences. This research programme will deliver new leading-edge multi and cross-disciplinary research in exciting and highly translatable areas of optics, imaging, data analysis and chemistry. Our proposed programme is driven by a clear "healthcare pull" from ICU (with application to diseases in other organs); it fits squarely with EPSRC goals in the Healthcare and Life Sciences sector. Enabling activities through our IRC will create a new generation of scientists, engineers and technologists with a translational agenda and mind-set for the benefit of the UK economy.

Training: A central part of our agenda is to break down traditional 'barriers' between physical and biomedical sciences. The PDRA's will benefit immensely from the interdisciplinary, translational thrust of the programme and the cross-fertilisation that will derive from the 'hub' in work package 6. Moreover, through our PhD students specifically engaged in cross-disciplinary projects we will create a new cadre of scientist who are multi-skilled and equipped to meet the challenges of applying new technologies to healthcare provision in the new era. They will gain a wide variety of both "hard and soft" skills that will be readily applied in a variety of employment sectors.

Industry: All the applicants have major interactions with industry, and most have direct personal experience of spin-off/spin-out companies. As the programme progresses new commercial opportunities will undoubtedly arise in fibre technology, engineering, novel chemical probes, image analysis and computing. When the integrative capacity of the programme is realised and FOSIP is applied to human disease and its models, commercialization prospects in the global healthcare arena will be significant.

General: Our multidisciplinary programme will provide many opportunities for involvement in public engagement and dissemination. Research fellows will participate at the International Science Festivals and become involved in a variety of out-reach activities such as the 'Researchers-in-Residence Programme' which places postgraduate students in local secondary schools allowing the public to benefit, as well as engaging the next generation of scientists.

Publications

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Perperidis A (2020) Image computing for fibre-bundle endomicroscopy: A review. in Medical image analysis

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Ucuncu M (2020) Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria. in Chemical communications (Cambridge, England)

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Mills B (2020) A matrix metalloproteinase activation probe for painting human tumours. in Chemical communications (Cambridge, England)

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Parker HE (2020) Core crosstalk in ordered imaging fiber bundles. in Optics letters

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Yerolatsitis S (2020) Birefringent Anti-Resonant Hollow-Core Fiber in Journal of Lightwave Technology

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Long J (2020) Frugal filtering optical lenses for point-of-care diagnostics. in Biomedical optics express

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Zhang S (2021) Solid-Phase Synthesis of Fluorescent Probes for Plasma Membrane Labelling. in Molecules (Basel, Switzerland)

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Mills B (2021) Molecular detection of Gram-positive bacteria in the human lung through an optical fiber-based endoscope. in European journal of nuclear medicine and molecular imaging

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Baibek A (2021) Dyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging. in Chemical communications (Cambridge, England)

 
Title PROTEUS ART EXHIBITION 
Description Ron O'Donnell - Photographs 
Type Of Art Artwork 
Year Produced 2015 
Impact • Proteus Art Exhibition - Introducing Proteus science through contemporary art. (Edinburgh/China) March 2015/ June 2015 Audience: Wider members of the public, academics, patients Engagement methods: Working with a contemporary artist to create portraits of our researchers which allowed dialogue about the specifics of their science research. Impact: High level of interest - changed hearts and minds in terms of who our scientists are and what the science can achieve- reflected in a questionnaire- high levels of satisfaction and desire to learn more. Event in China as sparked interest in examining how science communication can grow and become established in the Chinese culture - work still on going. 
 
Title • Proteus Science Ceilidh: Smart Probes Light Up Science Ceilidh 
Description • Proteus Science Ceilidh: Smart Probes Light Up Science Ceilidh (Edinburgh) December 2015 Audience: Wider members of the public (adult audience) Engagement methods: Dance and Music (using the arts to explain Smart Probe science) Impact: Increased public's appetite for more creative science engagement - learning through fun and accessible methods. More hits on Proteus website/Social Media post event. Feedback suggested participants would attend a similar event. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2015 
Impact • Proteus Science Ceilidh: Smart Probes Light Up Science Ceilidh (Edinburgh) December 2015 Audience: Wider members of the public (adult audience) Engagement methods: Dance and Music (using the arts to explain Smart Probe science) Impact: Increased public's appetite for more creative science engagement - learning through fun and accessible methods. More hits on Proteus website/Social Media post event. Feedback suggested participants would attend a similar event. 
 
Description New world-leading fibres for imaging and sensing - including disposable imaging fibre, Raman fibre (background free), flexible imaging fibres.
New world-leading CMSO SPAD detectors and their integration into systems that are entering clinic to allow a whole new dimension in optical medical imaging.
New world-leading chemical probes and their in-human use - for cancer margins and fibrosis and bacteria.
Major collaborations with industry to develop and push the technology in the area of cancer imaging/detection.
Highly trained staff - that are much in demand. Two PDRA's have won fellowships/gained fully independent academic positions.
Exploitation Route 12 Patents filed and we are looking to explore these in spinout ventures and in collaboration with various companies.

Detectors are being used in a number of different programmes.

Smart probes are being used in several different imaging scenarios

Some elements have gone into clinic and being used together and combined for clinical studies - with Phase-I studies on going.
Sectors Healthcare

URL http://www.proteus.ac.uk
 
Description We have been hugely active in the area of public engagement and advocacy. Please see the listed details for more depth - but in brief we have put in place a permeant exhibit ion the Glasgow Science centre, we worked with a local photography to put exhibits in local shopping centres, we have worked with the London Science Museum, we have (twice) been on the UK stand at AAAS and we have worked with a patient choir to help improve our standing of their needs and wants (rather than imposition). Teaching aids we have helped develop are being used in High Schools in Scotland. We have pushed our detector technology out to other groups - which offer huge advances in their life-time capabilities. Patients: Proteus will hopefully provide opportunities for clinicians to rapidly monitor events deep in the lungs of critically ill patients in 'real time' at the bedside. This will permit rapid point-of-care diagnosis and informed decision-making in intensive care units and patient stratification. We are actively involving patients in our programme to increase impact and involve patients in our research ideas and plans. NHS: Ultimately we hope to translate into reduced antibiotic use, reduced ventilator dependency and reduced mortality and morbidity with a proportionate economic benefit. Key goals include delineating infection from sterile inflammation in the lung. The gold standard MKT technology is a single wavelength/colour - and currently no bedside methods exist that are able to delineate pathological processes deep in the human lung in vivo in situ. Hence, the platform offers a disruptive paradigm changing technology.
First Year Of Impact 2015
Sector Education,Healthcare,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology
Impact Types Cultural,Societal,Policy & public services

 
Description American Association for the Advancement of Science Meeting 2018 - Invited to the meeting as a Flagship EPSRC project representing UK science on the main exhibition stage as well as the International Reception. Engagement Methods -Proteus Digital Lung Game - Designed by Proteus team in collaboration with Glasgow Science Centre. Impact: Raised awareness of EPSRC Proteus with UKRI CEO and wider RIUK team. Networked with senior academics, policy makers and US industries. Received media coverage for the project from the BBC.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Impact: Raised awareness of EPSRC Proteus with UKRI CEO and wider RIUK team. Engaged with senior academics, policy makers and US industries and wider public. Received media coverage for the project from the BBC.
URL http://www.bbc.co.uk/news/science-environment-43076783
 
Description Awarded The Royal Academy of Engineering Ingenious Grant - (Audience: Scottish Schools (students and teachers) and Research Centre for Teachers continuous Development. Engagement methods: Education tools that describe Proteus biomedical research. Impact: Embed Proteus Circuits! tools into Scottish curriculum to teach 12/13 year old students about bioengineering and its applications around health and wellbeing.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Inspire Students to consider STEM subjects and careers. Teach students about biomedical engineering in new engaging ways. bridge gaps between high school teachers and university research. Empower teachers to teach students about cutting edge research. Provide training and skills for researchers to engage widely and with confidence and expertise.
URL https://proteus.ac.uk/public-engagement/ingenious/our-project-circuits/
 
Description House of Lords Science and Technology Committee
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL http://www.parliamentlive.tv/Event/Index/3a9d05fd-a47f-411f-8173-5d99a1d53327
 
Description Proteus Showcase Event (Edinburgh) October 2014 - Note none of the options allowed below fit ! An open text box would be more useful !
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description The Royal Society of Edinburgh AMR (Antimicrobial Resistance) October 2014
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact --
 
Description • ICU Engagement Event February 2016 Audience: NHS ICU staff Engagement methods: Hands on demonstrations, posters, written materials Impact: Raise awareness of Proteus Science to end users - strengthened engagement, created possibilities for ongoing dialogue. • ICU Research Nurses Event February 2018 Audience: NHS ICU Research nurses Engagement methods: Hands on demonstrations, posters, written materials Impact: Raise awareness of Proteus Science to research nurses who may use Proteus technology. Introduced nurses to members of the Proteus team, strengthen engagement and interdisciplinary work.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact --
 
Description • Public and Patient Involvement - Funding Award Received from ACCORD February 2018 Audience: Respiratory Patients (Breathtakers and Breatheasy) Engagement methods: Dialogue sessions with patients, creative story telling workshops Impact: Creation of Proteus research pod at Glasgow science. Work ongoing to develop pilot studies for patient engagement using the Proteus interdisciplinarity model as an engagement framework.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact --
 
Description • Science and the Parliament (Edinburgh) November 2016 Audience: MPs, Senior Academics, Industry, Healthcare Professionals Engagement methods: Hands on demonstrations, videos, written materials Impact: Raise awareness of Proteus Science, forged a link with Scottish Chief Medical Officer - arranged meeting to visit Proteus labs post event.
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis
Amount € 4,400,000 (EUR)
Funding ID 825931 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2020 
End 12/2022
 
Description EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond
Amount £3,852,991 (GBP)
Funding ID EP/R005257/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 12/2022
 
Description IRC Next Steps Plus: Photonic Pathogen Theranostics - Point-of-care image guided photonic therapy of bacterial and fungal infection
Amount £1,100,000 (GBP)
Funding ID EP/R018669/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2022
 
Description IRC Next steps funding
Amount £3,900,000 (GBP)
Funding ID EP/R005257/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 02/2023
 
Description MRC CiC (none of the options below re grant type are right/suitable as it is a confidence in concept grant)
Amount £700,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description Multi-modal Manufacturing of Medical Devices (4MD)
Amount £1,302,969 (GBP)
Funding ID EP/P027415/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2017 
End 07/2022
 
Description Next generation endoscopes
Amount £665,103 (GBP)
Funding ID EP/S001123/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2018 
End 06/2021
 
Description Next-Generation Sensing For Human In Vivo Pharmacology- Accelerating Drug Development In Inflammatory Diseases
Amount £1,071,136 (GBP)
Funding ID EP/S025987/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 04/2022
 
Description Single Photons - Expanding the Spectrum (SPEXS)
Amount £5,265,567 (GBP)
Funding ID EP/S026428/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2024
 
Description Through-body TCSPC based real-time tracking to guide interventional medical procedures
Amount £315,108 (GBP)
Funding ID ST/S000763/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 03/2021
 
Description WT/CARB-X (none of the "type of funding" given below are really suitable)
Amount £2,500,000 (GBP)
Funding ID 208608/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 12/2022
 
Title Fluorescent life-time video rate CMOS SPAD detectors 
Description Fluorescent life-time video rate CMOS SPAD detectors have been developed across the team. They are being evaluated by other groups and organisations in a number of scenarios. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact Possible use in analysis of histology samples, real-time detection of cancer margins etc.. rapid life-time microscopy. 
 
Title Data for "High resolution air-clad imaging fibers" 
Description The data supporting the results presented in the paper "High resolution air-clad imaging fibers". This body of work is designed to provide an indication of the imaging performance of a novel, high resolution imaging coherent fibre bundle fabricated in the University of Bath's Centre for Photonics and Photonic Materials' facilities. Traditionally, the imaging fibres such as those used in medical endoscopes consist of solid doped and undoped silica glass. The novelty of our design is in having the cladding that is comprised of air-filled silica capillaries, achieving a cladding index close to that of air. This increase in index contrast with the cores (still solid doped silica) provides a higher numerical aperture waveguide. As a result, the light is better confined to the cores, and higher resolution, or a wider operational bandwidth, can be achieved. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Data for Quantitative characterisation of imaging fibres 
Description Images, code and data used to produce the figures in the paper Quantitative characterisation of imaging fibres. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
 
Title Data for the publication: Low index contrast imaging fibers 
Description This contains the images and raw data presented in the paper Low index contrast imaging fibres published in Optics Letters. The data includes the individual images used to demonstrate how the new fibres are made and the raw data used to determine the performance of the imaging fibres presented in the publication. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
 
Title Dataset for "Birefringent Anti-resonant Hollow-core Fiber" 
Description This dataset contains data supporting the results presented in the paper "Birefringent Anti-resonant Hollow-core Fiber" and the supplementary material. It includes the data used to plot each figure (in .xlsx format), together with simulated data obtained using COMSOL. Hollow-core fibres have demonstrated record performance in applications such as high-power pulse delivery, quantum computing, and sensing. However, their routine use is yet to become reality. A major obstacle is the ability to maintain the polarisation state of light over a broad range of wavelengths, while also ensuring single-mode guidance and attenuation that is low enough for practical applications that require only a few meters of fibre length (<1 dB/m). Here we simulated, fabricated and characterized a single-mode birefringent anti-resonant hollow-core fibre. The birefringence was achieved by introducing capillary tubes of different thicknesses, thereby creating reduced symmetry in the structure. The measured group birefringence is in good agreement with the calculated group birefringence from simulations across the fibre guidance band within the telecommunications C-band. At 1550 nm, we measured a group birefringence of 4.4E-5, which corresponds to a phase birefringence of 2.5E-5. The measured loss of the fibre was 0.46 dB/m at 1550 nm. The measured polarisation extinction ratio of the fibre at 1550 nm was 23.1 dB (25.7 dB) along the x-(y-) polarisation axis, relating to an h-parameter of 9.8E-4 (5.3E-4). 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL https://researchdata.bath.ac.uk/id/eprint/767
 
Title Dataset for Ultra-low background Raman sensing using a negative-curvature fibre and no distal optics 
Description Collected data for the results presented in "Ultra-low background Raman sensing using a negative-curvature fibre and no distal optics" demonstrating the use of a single hollow core negative curvature fibre for Raman and surface enhanced Raman spectroscopy sensing. This new optical fibre shows a 1000x background reduction compared to conventional fibres while maintaining the same collection efficiency. The dataset includes Raman and SERS spectra from different samples and attenuation data for a range of wavelengths for the negative curvature fibre. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Description Collaboration with BTG (Boston Scientific) 
Organisation BTG
Country United Kingdom 
Sector Private 
PI Contribution Use of Proteus imaging technology and hardware re cancer analysis and ablation
Collaborator Contribution cryo ablation system and design skills and expertise
Impact Confidential
Start Year 2018
 
Description Collaboration with Dundee Univ 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration, mentorship and supervision
Collaborator Contribution Collaboration, mentorship and supervision
Impact Activities on going
Start Year 2019
 
Description Collaboration with industrial partners 
Organisation Renishaw PLC
Department Renishaw Diagnostics Ltd
Country United Kingdom 
Sector Private 
PI Contribution Detectors or Raman
Collaborator Contribution Use of the detectors
Impact Confidential Multi-disiplionary
Start Year 2019
 
Description Collaboration with multiple univ partners 
Organisation Durham University
Country United Kingdom 
Sector Academic/University 
PI Contribution New detector designs and systems
Collaborator Contribution expertise and skills in the area of optical design
Impact Collaboration in new grants and new grant submissions. Collaboration is inter-disciplinary
Start Year 2017
 
Description Collaborations with multiple universities 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Detectors and software
Collaborator Contribution Use in histology analysis
Impact use of our detectors to support new applications and uses
Start Year 2019
 
Description This is an IRC - it is by definition a collaboration 
Organisation Durham University
Country United Kingdom 
Sector Academic/University 
PI Contribution The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath.
Collaborator Contribution Massive collaborations (please see the web site www.proteus.ac.uk)
Impact Please see list of publications/patents/engagement activities on the Proteus web site.
Start Year 2013
 
Description This is an IRC - it is by definition a collaboration 
Organisation Heriot-Watt University
Country United Kingdom 
Sector Academic/University 
PI Contribution The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath.
Collaborator Contribution Massive collaborations (please see the web site www.proteus.ac.uk)
Impact Please see list of publications/patents/engagement activities on the Proteus web site.
Start Year 2013
 
Description This is an IRC - it is by definition a collaboration 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath.
Collaborator Contribution Massive collaborations (please see the web site www.proteus.ac.uk)
Impact Please see list of publications/patents/engagement activities on the Proteus web site.
Start Year 2013
 
Description This is an IRC - it is by definition a collaboration 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution The IRC team comprises the Universities of Edinburgh, Heriot Watt and Bath.
Collaborator Contribution Massive collaborations (please see the web site www.proteus.ac.uk)
Impact Please see list of publications/patents/engagement activities on the Proteus web site.
Start Year 2013
 
Title - OPTICAL PROBE FOR THROMBIN 
Description OPTICAL PROBE FOR THROMBIN 
IP Reference WO2016151297 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title A SENSING STRUCTURE AND METHOD OF FORMING A SENSING STRUCTURE 
Description A SENSING STRUCTURE AND METHOD OF FORMING A SENSING STRUCTURE 
IP Reference WO2017203272 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title ENDOSCOPIC IMAGING APPARATUS AND METHOD 
Description ENDOSCOPIC IMAGING APPARATUS AND METHOD 
IP Reference WO2017174998 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidentail
 
Title FLUORESCENT POLYBRANCHED PROBES FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO 
Description FLUORESCENT POLYBRANCHED PROBES FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO 
IP Reference WO2016075484 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title FRAME SELECTION IN MEDICAL IMAGE DATA 
Description FRAME SELECTION IN MEDICAL IMAGE DATA 
IP Reference WO2017149310 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title FRET MOLECULAR PROBES WITH CLEAVABLE LINKERS FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO 
Description FRET MOLECULAR PROBES WITH CLEAVABLE LINKERS FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO 
IP Reference WO2016075481 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title Molecular probes for detecting gram-negative bacteria in vitro and in vivo 
Description Molecular probes for detecting gram-negative bacteria in vitro and in vivo 
IP Reference WO2016075483 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title OPTICAL IMAGING PROBES 
Description OPTICAL IMAGING PROBES 
IP Reference WO2012136958 
Protection Patent granted
Year Protection Granted 2017
Licensed Commercial In Confidence
Impact Confidential
 
Title OPTICAL PROBES FOR MATRIX METALLOPROTEINASES (the question below is wrong - protection is not received from a filing or if the PCT is published it has to go through national phases - and I cannot add this unless I put a date). 
Description OPTICAL PROBES FOR MATRIX METALLOPROTEINASES 
IP Reference WO2016151299 
Protection Patent application published
Year Protection Granted 2016
Licensed Commercial In Confidence
Impact confidential
 
Title OPTICAL SYSTEM AND METHOD 
Description A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light. 
IP Reference WO2018203088 
Protection Patent application published
Year Protection Granted 2018
Licensed Commercial In Confidence
Impact Confidential
 
Title SERS PROBE COMPRISING A DUAL-CORE OPTICAL FIBER AND A SPACER ONTO WHICH SERS-ACTIVE NANOPARTICLES ARE ATTACHED 
Description SERS PROBE COMPRISING A DUAL-CORE OPTICAL FIBER AND A SPACER ONTO WHICH SERS-ACTIVE NANOPARTICLES ARE ATTACHED 
IP Reference WO2017158331 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact Confidential
 
Title Bac-II 
Description Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC TWO. BAC TWO will be instilled directly into the lungs of 12 patients to assess whether it can label gram-negative bacteria in the human lung. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2016
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC TWO. BAC TWO will be instilled directly into the lungs of 12 patients to assess whether it can label gram-negative bacteria in the human lung. 
URL https://clinicaltrials.gov/ct2/show/NCT02491164?term=NCT02491164&rank=1
 
Title Exploratory clinical study of intrapulmonary microdosing of the BACterial detection probe (BAC ONE) 
Description Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC ONE. BAC ONE will be instilled directly into the lungs of 12 patients (with and without lung infection) to assess whether it can label bacteria in the human lung. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2018
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which is characterised by deterioration in their respiratory function, and changes on chest x-ray. The correct management for ARDS is identifying the underlying condition causing the deterioration and identifying appropriate targeted therapy. One such cause is pneumonia, caused by a bacterial infection in the lungs of a ventilated patient. The patients may have been ventilated due to pneumonia but they may also develop pneumonia whilst ventilated. Ventilator associated pneumonia (VAP) has significant mortality. Despite all the clinical and laboratory data at the investigators' disposal there remains great difficulty in the accurate diagnosis of pneumonia and therefore treatment is often given empirically. Therefore, there is an urgent clinical need for accurate methods to diagnose the presence of bacteria deep in the lung in ventilated critically ill patients. As such, the investigating team have developed and synthesised an imaging agent called BAC ONE. BAC ONE will be instilled directly into the lungs of 12 patients (with and without lung infection) to assess whether it can label bacteria in the human lung. 
URL https://clinicaltrials.gov/ct2/show/NCT02558062?term=NCT02558062&rank=1
 
Title FIB-ONE 
Description Brief Summary: While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function. In other words, affected 'fibrotic' tissues are unable to heal back to normal and therefore don't work as effectively as they normally would. In the case of the lung, fibrosis can occur across large parts of the lung such as in conditions like Idiopathic Pulmonary Fibrosis (IPF) and sarcoidosis or it can occur in much smaller patches such as around the borders of some lung tumours. At the moment the investigators don't fully understand the mechanisms of fibrosis and so therefore cannot monitor or treat these conditions as effectively as the investigators could. Despite the significant global financial burden of these diseases, treatment options are very limited and monitoring of disease progression remains a real challenge. In an effort to address this problem, the research team have designed and synthesised an imaging agent (FIB ONE) that can detect fibrosis in the lung. FIB ONE will be used at very low concentrations in patients with a lung condition characterised by excessive activity of the fibroproliferative pathway either scheduled for a routine bronchoscopy or elective surgery. FIB ONE will be administered directly into the lungs during a bronchoscopy procedure and images of the lungs will be analysed. As part of this study, the research team's novel endomicroscopy detection system will be compared to equipment that is routinely used in the NHS when imaging the FIB ONE probe. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Brief Summary: While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function. In other words, affected 'fibrotic' tissues are unable to heal back to normal and therefore don't work as effectively as they normally would. In the case of the lung, fibrosis can occur across large parts of the lung such as in conditions like Idiopathic Pulmonary Fibrosis (IPF) and sarcoidosis or it can occur in much smaller patches such as around the borders of some lung tumours. At the moment the investigators don't fully understand the mechanisms of fibrosis and so therefore cannot monitor or treat these conditions as effectively as the investigators could. Despite the significant global financial burden of these diseases, treatment options are very limited and monitoring of disease progression remains a real challenge. In an effort to address this problem, the research team have designed and synthesised an imaging agent (FIB ONE) that can detect fibrosis in the lung. FIB ONE will be used at very low concentrations in patients with a lung condition characterised by excessive activity of the fibroproliferative pathway either scheduled for a routine bronchoscopy or elective surgery. FIB ONE will be administered directly into the lungs during a bronchoscopy procedure and images of the lungs will be analysed. As part of this study, the research team's novel endomicroscopy detection system will be compared to equipment that is routinely used in the NHS when imaging the FIB ONE probe. 
URL https://clinicaltrials.gov/ct2/show/NCT02604862?term=NCT02604862&rank=1
 
Description AAAS Meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact AAAS Meeting 2019 - Invited to the meeting as a Flagship EPSRC project representing UK science on the main exhibition stage as well as the International Reception.
Feb 2019
Audience: American Academics, Members of Congress, American Industries, RIUK team lead by Sir Mark Walport (CEO) World Media Teams, Global stakeholders (academics, policy makers) students and wider publics
Engagement methods: Proteus Technology Versicolour
Impact: Raised awareness of EPSRC Proteus with UKRI CEO and wider RIUK team. Networked with senior academics, policy makers and US industries. Created new collaborations with industrial partners
Year(s) Of Engagement Activity 2019
URL https://www.ukri.org/aaas/
 
Description Development of an ICU Patient and Public Involvement Group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Public and Patient Involvement -I CU PPI GROUP
March 2018
Audience: ICU Patients and families
Engagement methods: Dialogue sessions with patients, partnership building activities, developing PPI projects
Impact: Creation of Edinburgh's first ICU PPI group, working with the Critical Care Team in Edinburgh and nationally with ICU Steps - has allowed ICU patients to take part in Proteus engagement activities and has strengthen Proteus' PPI portfolio
Year(s) Of Engagement Activity 2018
URL https://www.ed.ac.uk/clinical-sciences/divisionpgdi/anaesthesia/news-views/icusteps-patient-and-fami...
 
Description EPSRC Our Health - A model of community-based engagement - Teaching and Learning Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact EPSRC Our Health - A model of community-based engagement - The University of Edinburgh, Teaching and Learning Conference. Our Health was asked to present as an example of best practice in engaged- community based research.
Year(s) Of Engagement Activity 2020
URL https://www.ed.ac.uk/clinical-sciences/our-health
 
Description EPSRC Our Health - Develops new partnership with NHS Lothian as part of COVID response. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact EPSRC Our Health - Develops new partnership with NHS Lothian as part of COVID response. New community- engagement project developed and networks created. Secured NHS Lothian funding (£8K) as part of the partnership.
Year(s) Of Engagement Activity 2021
 
Description EPSRC Our Health - Dr Henk Mulder Visit (Science Shop Expert, The University of Groningen) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact EPSRC Our Health - Dr Henk Mulder Visit (Science Shop Expert, The University of Groningen)
April 2018
Audience: Local community, patient groups, undergraduates/postgraduates, academics and Public Engagement Professionals
Engagement methods: Presentation and workshop
Impact: Dr Henk Mulder's visit for part of a University wide consultation around the Science Shop model for community/patient engagement and resulted in the funding and launch of Our Health
Year(s) Of Engagement Activity 2018
 
Description EPSRC Our Health - Led COVID response with partners in India (NIRT) to collaborate with Indian TB clinicians 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EPSRC Our Health - Led COVID response with partners in India (NIRT) to collaborate with Indian TB clinicians to investigate the impact of COVID on TB doctors and patients.
Year(s) Of Engagement Activity 2020
 
Description EPSRC Our Health - The First UK Interdisciplinary Science Shop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact EPSRC Our Health - The First UK Interdisciplinary Science Shop
June 2018
Audience: Local community, patient groups, undergraduates/postgraduates, academics and Public Engagement professionals
Engagement methods: Community based research projects around Health and well being
Impact: EPSRC Our Health (within first 6 months of launch) has created national and international impact. Our Health was selected to host the Experienced Practice Learning Exchange for international delegates as part of The National Co ordinating Centre's National ENGAGE 2018 Conference.
EPSRC Our Health has also been asked to work in partnership with UKRI International PE team to develop global projects for Our Health. Our Health has impacted the local community by creating new knowledge around health and well being with community partners.
Year(s) Of Engagement Activity 2018
URL https://proteus.ac.uk/public-engagement/developing-community-partnerships/our-health/about-our-healt...
 
Description Living Knowledge 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Living Knowledge 2018 - Invited as a speaker to the Living Knowledge Confrenec (Budapest) to present EPSRC Our Health and share best practice around this new Interdisciplinary model of a science shop
July 2018
Audience: International Public Engagement Delegates and Community partners
Engagement methods: Workshops, presentations and visits to local communities to talk with people about their involvement in PE.
Impact: EPSRC Our Health is now established with in the European community and is part of a wider network and a leader in the field of interdisciplinary community research
Year(s) Of Engagement Activity 2018
URL https://www.livingknowledge.org/lk8/
 
Description Proteus Partnership with Msc Science Communication Programme 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Proteus Partnership with Msc Science Communication Programme
2018
Audience: Eight Science Communication Master Students work with Proteus each year engaging wider publics and community partners.
Engagement methods: science writing, activity based presentations, dialogic workshops and creative co inquiry.
Impact: developed a community of public engagement practice throughout the university and with local universities. Sharing of best practice, improving quality and impact of public engagement work. Work created by students have promoted and raised the profile of Proteus across a wide range of project stakeholders.
Year(s) Of Engagement Activity 2018
 
Description Proteus Public Engagement (PE) Strategic Influence 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Proteus Public Engagement (PE) Strategic Influence - Proteus represented at the Strategic PE Group, The University of Edinburgh
March 2018
Audience: Senior colleagues working within PE and members of the wider public, The University of Edinburgh (UoE)
Engagement methods: Committee discussions, development of UoE PE strategy
Impact: Proteus PE influences the strategic direction of PE for The University of Edinburgh
Year(s) Of Engagement Activity 2018
URL https://www.ed.ac.uk/institute-academic-development/research-roles/public-engagement/pe-strategy
 
Description Science at Heriot Watt 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Science at Heriot Watt 2018 (Heriot Watt University)
April 2018
Audience: Wider Public
Engagement methods: Hands on demonstrations, activities and storytelling
Impact: Raise awareness of Proteus Science with family audience. Strengthened links with Heriot Watt University.
Year(s) Of Engagement Activity 2018
 
Description The Edinburgh International Science Festival (Edinburgh) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Edinburgh International Science Festival (Edinburgh)
April 2018
Audience: Wider Public
Engagement methods: Hands on demonstrations, activities and storytelling
Impact: Raised awareness of Proteus Science with family audiences. Created interest amongst researcher working in infectious diseases in Roslin centre - formed new collaboration with Dr Kenneth Ballie around PE activities
Year(s) Of Engagement Activity 2018
 
Description The International Edinburgh Book Festival - EPSRC Proteus/ EPSRC Our Health 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The International Edinburgh Book Festival
August 2018
Audience: Wider Public
Engagement methods: Hands on demonstrations and research art exhibition. Our Health students and community partners formed a choir and sang.
Impact: Principal of The University of Edinburgh attended and gave strong support for Proteus/Our Health. As a consequence of this event the The University of Edinburgh, Proteus/Our Health and The International Edinburgh Book Festival have agreed to work together on further PE activities
Year(s) Of Engagement Activity 2018
 
Description UKRI Festival of Tomorrow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact UKRI Festival of Tomorrow - to showcase EPSRC-UKRI research. Created a virtual booth for public audience to view aspects of IRC Proteus research.
Year(s) Of Engagement Activity 2021
URL https://www.scienceswindon.com/festival-of-tomorrow