Core Capability for Chemistry Research - Strategic Investment in Mass Spectrometry
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
See Case for Support and Pathways to Impact
Planned Impact
Attached as separate document.
Organisations
Publications
Abas H
(2019)
Asymmetric and Geometry-Selective a-Alkenylation of a-Amino Acids.
in Angewandte Chemie (International ed. in English)
Abood A
(2015)
Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potential
in RSC Advances
Abrams R
(2018)
Transition Metal Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts.
in Angewandte Chemie (International ed. in English)
Ackrill TD
(2015)
Synthesis of Diarylheptanoid Scaffolds Inspired by Calyxins I and J.
in Organic letters
Adam C
(2018)
The Role of Terminal Functionality in the Membrane and Antibacterial Activity of Peptaibol-Mimetic Aib Foldamers.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Aggarwal V
(2015)
Palladium-Catalyzed Reactions of Allylic Boronic Esters with Nucleophiles: Novel Umpolung Reactivity
in Synlett
Aggarwal VK
(2014)
Comprehensive Organic Synthesis II
Aichhorn S
(2017)
Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence.
in Journal of the American Chemical Society
Al Fahad A
(2014)
The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid.
in Angewandte Chemie (International ed. in English)
Albanese KI
(2024)
Rationally seeded computational protein design of ?-helical barrels.
in Nature chemical biology
Alberti F
(2017)
Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives.
in Nature communications
Amer MM
(2018)
Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic a-Amino Acids.
in Organic letters
Arena G
(2013)
Concise synthesis of (+)-allo-kainic acid via MgI2-mediated tandem aziridine ring opening-formal [3 + 2] cycloaddition.
in Organic letters
Armstrong JPK
(2015)
Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue.
in Nature communications
Armstrong RJ
(2017)
Conjunctive functionalization of vinyl boronate complexes with electrophiles: a diastereoselective three-component coupling.
in Chemical communications (Cambridge, England)
Armstrong RJ
(2017)
Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling.
in Organic letters
Armstrong RJ
(2018)
Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer.
in Angewandte Chemie (International ed. in English)
Armstrong RJ
(2017)
Stereodivergent Olefination of Enantioenriched Boronic Esters.
in Angewandte Chemie (International ed. in English)
Arz MI
(2019)
Ring-Opening Polymerization of Cyclic Phosphonates: Access to Inorganic Polymers with a PV-O Main Chain.
in Journal of the American Chemical Society
Asghar S
(2017)
Cobalt-Catalyzed Suzuki Biaryl Coupling of Aryl Halides.
in Angewandte Chemie (International ed. in English)
Baars H
(2017)
Synthesis of Alfaprostol and PGF2a through 1,4-Addition of an Alkyne to an Enal Intermediate as the Key Step.
in Organic letters
Bailey AM
(2016)
Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production.
in Scientific reports
Bailey JA
(2015)
Single oxygen-atom insertion into P-B bonds: on- and off-metal transformation of a borylphosphine into a borylphosphinite.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Bailey JA
(2014)
Mono-, di-, and triborylphosphine analogues of triarylphosphines.
in Inorganic chemistry
Bailey JA
(2014)
A simple route to azaborinylphosphines: isoelectronic B-N analogues of arylphosphine ligands.
in Chemical communications (Cambridge, England)
Baker A
(2018)
Thermally induced reversible and reprogrammable actuation of tough hydrogels utilising ionoprinting and iron coordination chemistry
in Sensors and Actuators B: Chemical
Baker EG
(2017)
Engineering protein stability with atomic precision in a monomeric miniprotein.
in Nature chemical biology
Baker EG
(2015)
Local and macroscopic electrostatic interactions in single a-helices.
in Nature chemical biology
Balieu S
(2015)
Toward ideality: the synthesis of (+)-kalkitoxin and (+)-hydroxyphthioceranic acid by assembly-line synthesis.
in Journal of the American Chemical Society
Ball LT
(2014)
Gold-catalyzed oxidative coupling of arylsilanes and arenes: origin of selectivity and improved precatalyst.
in Journal of the American Chemical Society
Balmond EI
(2014)
A 3,4-trans-fused cyclic protecting group facilitates a-selective catalytic synthesis of 2-deoxyglycosides.
in Angewandte Chemie (International ed. in English)
Beattie RJ
(2016)
Stereoselective synthesis of protected l- and d-dideoxysugars and analogues via Prins cyclisations.
in Chemical science
Bedford R
(2013)
Synthesis of murrayaquinone A and analogues via ring-closing C-H arylation
in Tetrahedron
Bedford R
(2014)
Iron Phosphine Catalyzed Cross-Coupling of Tetraorganoborates and Related Group 13 Nucleophiles with Alkyl Halides
in Organometallics
Bedford R
(2015)
Towards Iron-Catalysed Suzuki Biaryl Cross-Coupling: Unusual Reactivity of 2-Halobenzyl Halides
in Synthesis
Bedford R
(2014)
Iron-Catalyzed Borylation of Alkyl, Allyl, and Aryl Halides: Isolation of an Iron(I) Boryl Complex
in Organometallics
Bedford RB
(2016)
Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens.
in The Journal of organic chemistry
Bedford RB
(2016)
The influence of the ligand chelate effect on iron-amine-catalysed Kumada cross-coupling.
in Dalton transactions (Cambridge, England : 2003)
Bedford RB
(2013)
Simplifying iron-phosphine catalysts for cross-coupling reactions.
in Angewandte Chemie (International ed. in English)
Bedford RB
(2014)
TMEDA in iron-catalyzed Kumada coupling: amine adduct versus homoleptic "ate" complex formation.
in Angewandte Chemie (International ed. in English)
Bedford RB
(2014)
Expedient iron-catalyzed coupling of alkyl, benzyl and allyl halides with arylboronic esters.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Bedford RB
(2015)
Facile hydrolysis and alcoholysis of palladium acetate.
in Angewandte Chemie (International ed. in English)
Bedford RB
(2017)
Isoindolinones via Copper-Catalyzed Intramolecular Benzylic C-H Sulfamidation.
in The Journal of organic chemistry
Bedford RB
(2015)
Catalyst-Switchable Regiocontrol in the Direct Arylation of Remote C-H Groups in Pyrazolo[1,5-a]pyrimidines.
in Angewandte Chemie (International ed. in English)
Beesley JL
(2018)
Modifying Self-Assembled Peptide Cages To Control Internalization into Mammalian Cells.
in Nano letters
Beesley JL
(2019)
Correction to Modifying Self-Assembled Peptide Cages To Control Internalization into Mammalian Cells.
in Nano letters
Bell OA
(2015)
Self-Assembly of a Functional Oligo(Aniline)-Based Amphiphile into Helical Conductive Nanowires.
in Journal of the American Chemical Society
Benito-Alifonso D
(2016)
Imidazolium-tagged glycan probes for non-covalent labeling of live cells.
in Chemical communications (Cambridge, England)
Benito-Alifonso D
(2013)
Synthesis of mucin-type O-glycan probes as aminopropyl glycosides.
in Beilstein journal of organic chemistry
Bennett N
(2016)
Mesoporous tertiary oxides via a novel amphiphilic approach
in APL Materials
| Description | The new instruments within the Mass Spectrometry Facility now allow in-depth analysis of complex mixtures, the ability to examine the interactions of molecules with other species such as in inorganic complexes or protein-drug complexes, as well as the analysis of high molecular weight species, such as polymers and proteins. The acquisition of these new instruments has allowed us to significantly advance our understanding of specific chemical reactions, as well as to analyze in detail synthetic approaches to naturally occurring scaffolds, which have the potential to lead to novel therapeutic compounds. Cyclohexane based anion carriers are being designed and synthesized, which may have the potential for channel replacement therapy in cases of cystic fibrosis, synthetic scaffolds are finding applications as medicinal sensors, while rationally designed porous solids are a potential solution to the gas storage problem. The properties of non-proteinogenic amino acids are also of interest, especially those features, which make them suitable for the study of Alzheimer's disease. Scaffolds are being designed with the purpose of supporting cell or tissue growth, enzymes are being rationally developed to act as specific catalysts, while compounds that can mimic biological boundaries could be used as protocells for drug delivery. |
| Exploitation Route | Findings from mass spectrometric analyses carried out will advance mechanistic understanding which will enable the production of new materials. The rational design of compounds which may play a role in energy harvesting and storage, or which may act as drugs with potential healthcare uses will also stimulate research both within academia as well as industry. We are training the current cohorts of PhD students from the Centres for Doctoral training as well as post doctoral researchers within individual groups. These students may eventually progress to senior positions in academia or industry. Output from the MS facility is also being used in undergraduate teaching as well as outreach events with the aim of inspiring the next generation of chemists. |
| Sectors | Chemicals Education Energy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | Chemistry departments within UK universities make significant contributions to worldwide societal challenges through impacts based in drug discovery, energy and new materials. The School of Chemistry at the University of Bristol is an acknowledged leader in synthesis, materials and supramolecular chemistry, as well as chemical biology and research groups are working towards the production of bioactive compounds, polymeric materials and surfactants with applications in energy harvesting and storage, as well as on synthetic receptors with future healthcare potential. Cutting-edge analytical equipment underpins progress in all of these research areas and impacts arising from investment in Mass Spectrometry will broadly fall into four groups: in industry and academia as well as on the general public and society. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Education,Energy,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural Societal Economic |
| Description | ABEL |
| Amount | € 2,467,844 (EUR) |
| Funding ID | LS9,ERC-2013-ADG |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 02/2014 |
| End | 01/2019 |
| Description | AMR Collaborative grant - Exploring Nature's Silent Pharmacy |
| Amount | £2,400,000 (GBP) |
| Funding ID | MR/N029909/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | BIOMOLECULAR ORIGAMI |
| Amount | £333,189 (GBP) |
| Funding ID | BB/M005615/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 08/2017 |
| Description | BP/EPSRC iCASE: Analysis of complex petrochemical deposits. |
| Amount | £80,670 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | Cobalt- and Nickel-based Polymetallocenes: Functional Metallopolymers from Earth-Abundant Metals |
| Amount | £263,683 (GBP) |
| Funding ID | EP/N030702/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2018 |
| Description | Dynamic communication through reorganisable hydrogen bond networks |
| Amount | £195,989 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2019 |
| Description | ERC FRESCO |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 670668 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2015 |
| End | 10/2020 |
| Description | Factory in a Fumehood: Reagentless Flow Reactors as Enabling Techniques for Manufacture |
| Amount | £940,746 (GBP) |
| Funding ID | EP/L003325/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 02/2017 |
| Description | Fellowship David Tilly |
| Amount | £121,492 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Impact acceleration |
| Amount | £68,205 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | LoLa |
| Amount | £3,484,653 (GBP) |
| Funding ID | BB/M002969/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2019 |
| Description | Longer and Larger Grants |
| Amount | £3,500,000 (GBP) |
| Funding ID | BB/K002341/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 07/2018 |
| Description | MRC CiC, Cancer Research Technology and Guy Newton Translational Grant. IGF2-TRAP development. |
| Amount | £130,424 (GBP) |
| Funding ID | BRR00040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 07/2017 |
| Description | Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism |
| Amount | £724,553 (GBP) |
| Funding ID | EP/N024117/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2019 |
| Description | Optoelectronic Nanostructures via Polythiophene Block Copolymer Self-Assembly |
| Amount | £544,263 (GBP) |
| Funding ID | EP/K017799/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 03/2017 |
| Description | Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture |
| Amount | £6,486,390 (GBP) |
| Funding ID | EP/P013341/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2022 |
| Description | Protolife-inspired materials chemistry |
| Amount | £675,541 (GBP) |
| Funding ID | EP/L002957/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 06/2017 |
| Description | Quaternary amino acids on scale for medicine and agroscience |
| Amount | £104,109 (GBP) |
| Funding ID | 727296 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 08/2016 |
| End | 03/2019 |
| Description | SAGE |
| Amount | £731,565 (GBP) |
| Funding ID | BB/L010518/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2017 |
| Description | Synthesis and Biology of Prostanoids |
| Amount | £1,061,277 (GBP) |
| Funding ID | EP/M012530/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 04/2020 |
| Description | Synthetic Biology |
| Amount | £13,528,180 (GBP) |
| Funding ID | BB/L01386X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2019 |
| Description | The Ironworks: a mechanistic foundry for iron-catalysed cross-coupling |
| Amount | £630,649 (GBP) |
| Funding ID | EP/K012258/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 07/2017 |