Core Capability for Chemistry Research - Strategic Investment in Mass Spectrometry
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
See Case for Support and Pathways to Impact
Planned Impact
Attached as separate document.
Organisations
Publications
Galan M
(2013)
Recent Developments in the Application of Organocatalysis to Glycosylations
in Synlett
Gallagher T
(2015)
Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones
in Synlett
Galloway JM
(2021)
De Novo Designed Peptide and Protein Hairpins Self-Assemble into Sheets and Nanoparticles.
in Small (Weinheim an der Bergstrasse, Germany)
Galloway JM
(2018)
Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages.
in ACS nano
Ganesh V
(2017)
Alkynyl Moiety for Triggering 1,2-Metallate Shifts: Enantiospecific sp2 -sp3 Coupling of Boronic Esters with p-Arylacetylenes.
in Angewandte Chemie (International ed. in English)
Ganesh V
(2018)
Chiral Aniline Synthesis via Stereospecific C(sp3)-C(sp2) Coupling of Boronic Esters with Aryl Hydrazines.
in Organic letters
Gao SS
(2017)
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.
in Angewandte Chemie (International ed. in English)
Gao SS
(2014)
Biosynthesis of mupirocin by Pseudomonas fluorescens NCIMB 10586 involves parallel pathways.
in Journal of the American Chemical Society
GarcÃa-Ruiz C
(2017)
Stereospecific Allylic Functionalization: The Reactions of Allylboronate Complexes with Electrophiles.
in Journal of the American Chemical Society
Glaisyer EL
(2018)
Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation.
in Organic letters
Gonzalez-Alvarez M
(2016)
How a Small Modification of the Corona-Forming Block Redirects the Self-Assembly of Crystalline-Coil Block Copolymers in Solution
in Macromolecules
Gratzer K
(2017)
Signal transduction in oligoamide foldamers by selective non-covalent binding of chiral phosphates at a urea binding site.
in Organic & biomolecular chemistry
Grélaud S
(2018)
Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C-H Oxidative Addition
in Journal of the American Chemical Society
Haddow MF
(2016)
Aminophobanes: hydrolytic stability, tautomerism and application in Cr-catalysed ethene oligomerisation.
in Dalton transactions (Cambridge, England : 2003)
Hailes RL
(2016)
Polyferrocenylsilanes: synthesis, properties, and applications.
in Chemical Society reviews
Hailes RLN
(2019)
Ring-Opening Polymerisation of Low-Strain Nickelocenophanes: Synthesis and Magnetic Properties of Polynickelocenes with Carbon and Silicon Main Chain Spacers.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Haines AS
(2013)
A conserved motif flags acyl carrier proteins for ß-branching in polyketide synthesis.
in Nature chemical biology
Hall JE
(2016)
Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas.
in Angewandte Chemie (International ed. in English)
Harper MJ
(2017)
Oxidative 1,2-Difunctionalization of Ethylene via Gold-Catalyzed Oxyarylation.
in Journal of the American Chemical Society
Harper MJ
(2018)
Oxidative Addition, Transmetalation, and Reductive Elimination at a 2,2'-Bipyridyl-Ligated Gold Center.
in Journal of the American Chemical Society
Harrington L
(2021)
De novo design of a reversible phosphorylation-dependent switch for membrane targeting.
in Nature communications
Hayward D
(2016)
An investigation into the hexagonal phases formed in high-concentration dispersions of well-defined cylindrical block copolymer micelles
in Liquid Crystals
Hazelden IR
(2018)
Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates.
in Angewandte Chemie (International ed. in English)
Hazelden IR
(2016)
Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides.
in Angewandte Chemie (International ed. in English)
He L
(2015)
Nucleophile-Selective Cross-Coupling Reactions with Vinyl and Alkynyl Bromides on a Dinucleophilic Aromatic Substrate
in European Journal of Organic Chemistry
He L
(2015)
Synthesis of poly(thiophene-alt-pyrrole) from a difunctionalized thienylpyrrole by Kumada polycondensation
in Tetrahedron
He X
(2017)
Complex and Hierarchical 2D Assemblies via Crystallization-Driven Self-Assembly of Poly(l-lactide) Homopolymers with Charged Termini.
in Journal of the American Chemical Society
He X
(2017)
Two-dimensional assemblies from crystallizable homopolymers with charged termini.
in Nature materials
Heinrich AC
(2013)
Dual selectivity: electrophile and nucleophile selective cross-coupling reactions on a single aromatic substrate.
in Organic letters
Helten H
(2013)
Paramagnetic titanium(III) and zirconium(III) metallocene complexes as precatalysts for the dehydrocoupling/dehydrogenation of amine-boranes.
in Angewandte Chemie (International ed. in English)
Henderson AS
(2015)
Nucleophilic Aromatic Substitution (SNAr) as an Approach to Challenging Carbohydrate-Aryl Ethers.
in Organic letters
Henderson AS
(2016)
Carbohydrates as enantioinduction components in stereoselective catalysis.
in Organic & biomolecular chemistry
Henderson AS
(2014)
Carbohydrate-based N-heterocyclic carbenes for enantioselective catalysis.
in Organic & biomolecular chemistry
Hernandez LW
(2018)
Nickel-Catalyzed Dearomative trans-1,2-Carboamination.
in Journal of the American Chemical Society
Hesse MJ
(2014)
Highly selective allylborations of aldehydes using a,a-disubstituted allylic pinacol boronic esters.
in Angewandte Chemie (International ed. in English)
Hilditch A
(2023)
Assembling membraneless organelles from de novo designed proteins
Hilditch AT
(2024)
Assembling membraneless organelles from de novo designed proteins.
in Nature chemistry
Hill JE
(2018)
Polycyclic Indoline Derivatives by Dearomatizing Anionic Cyclization of Indole and Tryptamine-Derived Ureas.
in Organic letters
Hill JE
(2018)
Consecutive Ring Expansion and Contraction for the Synthesis of 1-Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors.
in Angewandte Chemie (International ed. in English)
Hill S
(2017)
Correction: Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications.
in Beilstein journal of organic chemistry
Hill S
(2017)
Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications.
in Beilstein journal of organic chemistry
Howgego JD
(2013)
An accessible bicyclic architecture for synthetic lectins.
in Chemical communications (Cambridge, England)
Hussain S
(2014)
Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity
in Phytochemistry Letters
Hussain Syed Hamid
(2013)
A New Bezoxepin Derivative from
Senecio desfontainei
in RECORDS OF NATURAL PRODUCTS
Illa O
(2013)
Practical and highly selective sulfur ylide-mediated asymmetric epoxidations and aziridinations using a cheap and readily available chiral sulfide: extensive studies to map out scope, limitations, and rationalization of diastereo- and enantioselectivities.
in Journal of the American Chemical Society
Iqbal Z
(2018)
Investigations into the biosynthesis of the antifungal strobilurins.
in Organic & biomolecular chemistry
Jackson DR
(2018)
Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.
in ACS chemical biology
Jardim G
(2017)
Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones
in European Journal of Medicinal Chemistry
| Description | The new instruments within the Mass Spectrometry Facility now allow in-depth analysis of complex mixtures, the ability to examine the interactions of molecules with other species such as in inorganic complexes or protein-drug complexes, as well as the analysis of high molecular weight species, such as polymers and proteins. The acquisition of these new instruments has allowed us to significantly advance our understanding of specific chemical reactions, as well as to analyze in detail synthetic approaches to naturally occurring scaffolds, which have the potential to lead to novel therapeutic compounds. Cyclohexane based anion carriers are being designed and synthesized, which may have the potential for channel replacement therapy in cases of cystic fibrosis, synthetic scaffolds are finding applications as medicinal sensors, while rationally designed porous solids are a potential solution to the gas storage problem. The properties of non-proteinogenic amino acids are also of interest, especially those features, which make them suitable for the study of Alzheimer's disease. Scaffolds are being designed with the purpose of supporting cell or tissue growth, enzymes are being rationally developed to act as specific catalysts, while compounds that can mimic biological boundaries could be used as protocells for drug delivery. |
| Exploitation Route | Findings from mass spectrometric analyses carried out will advance mechanistic understanding which will enable the production of new materials. The rational design of compounds which may play a role in energy harvesting and storage, or which may act as drugs with potential healthcare uses will also stimulate research both within academia as well as industry. We are training the current cohorts of PhD students from the Centres for Doctoral training as well as post doctoral researchers within individual groups. These students may eventually progress to senior positions in academia or industry. Output from the MS facility is also being used in undergraduate teaching as well as outreach events with the aim of inspiring the next generation of chemists. |
| Sectors | Chemicals Education Energy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | Chemistry departments within UK universities make significant contributions to worldwide societal challenges through impacts based in drug discovery, energy and new materials. The School of Chemistry at the University of Bristol is an acknowledged leader in synthesis, materials and supramolecular chemistry, as well as chemical biology and research groups are working towards the production of bioactive compounds, polymeric materials and surfactants with applications in energy harvesting and storage, as well as on synthetic receptors with future healthcare potential. Cutting-edge analytical equipment underpins progress in all of these research areas and impacts arising from investment in Mass Spectrometry will broadly fall into four groups: in industry and academia as well as on the general public and society. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Education,Energy,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural Societal Economic |
| Description | ABEL |
| Amount | € 2,467,844 (EUR) |
| Funding ID | LS9,ERC-2013-ADG |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 02/2014 |
| End | 01/2019 |
| Description | AMR Collaborative grant - Exploring Nature's Silent Pharmacy |
| Amount | £2,400,000 (GBP) |
| Funding ID | MR/N029909/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | BIOMOLECULAR ORIGAMI |
| Amount | £333,189 (GBP) |
| Funding ID | BB/M005615/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 08/2017 |
| Description | BP/EPSRC iCASE: Analysis of complex petrochemical deposits. |
| Amount | £80,670 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | Cobalt- and Nickel-based Polymetallocenes: Functional Metallopolymers from Earth-Abundant Metals |
| Amount | £263,683 (GBP) |
| Funding ID | EP/N030702/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2018 |
| Description | Dynamic communication through reorganisable hydrogen bond networks |
| Amount | £195,989 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2019 |
| Description | ERC FRESCO |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 670668 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2015 |
| End | 10/2020 |
| Description | Factory in a Fumehood: Reagentless Flow Reactors as Enabling Techniques for Manufacture |
| Amount | £940,746 (GBP) |
| Funding ID | EP/L003325/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 02/2017 |
| Description | Fellowship David Tilly |
| Amount | £121,492 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Impact acceleration |
| Amount | £68,205 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | LoLa |
| Amount | £3,484,653 (GBP) |
| Funding ID | BB/M002969/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2019 |
| Description | Longer and Larger Grants |
| Amount | £3,500,000 (GBP) |
| Funding ID | BB/K002341/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 07/2018 |
| Description | MRC CiC, Cancer Research Technology and Guy Newton Translational Grant. IGF2-TRAP development. |
| Amount | £130,424 (GBP) |
| Funding ID | BRR00040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 07/2017 |
| Description | Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism |
| Amount | £724,553 (GBP) |
| Funding ID | EP/N024117/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2019 |
| Description | Optoelectronic Nanostructures via Polythiophene Block Copolymer Self-Assembly |
| Amount | £544,263 (GBP) |
| Funding ID | EP/K017799/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 03/2017 |
| Description | Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture |
| Amount | £6,486,390 (GBP) |
| Funding ID | EP/P013341/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2022 |
| Description | Protolife-inspired materials chemistry |
| Amount | £675,541 (GBP) |
| Funding ID | EP/L002957/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 06/2017 |
| Description | Quaternary amino acids on scale for medicine and agroscience |
| Amount | £104,109 (GBP) |
| Funding ID | 727296 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 08/2016 |
| End | 03/2019 |
| Description | SAGE |
| Amount | £731,565 (GBP) |
| Funding ID | BB/L010518/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2017 |
| Description | Synthesis and Biology of Prostanoids |
| Amount | £1,061,277 (GBP) |
| Funding ID | EP/M012530/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 04/2020 |
| Description | Synthetic Biology |
| Amount | £13,528,180 (GBP) |
| Funding ID | BB/L01386X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2019 |
| Description | The Ironworks: a mechanistic foundry for iron-catalysed cross-coupling |
| Amount | £630,649 (GBP) |
| Funding ID | EP/K012258/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 07/2017 |