Core Capability for Chemistry Research - Strategic Investment in Mass Spectrometry
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
See Case for Support and Pathways to Impact
Planned Impact
Attached as separate document.
Organisations
Publications
Matlock JV
(2014)
Synthesis of a-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles.
in The Journal of organic chemistry
Matlock JV
(2015)
Synthesis of 6- and 7-Membered N-Heterocycles Using a-Phenylvinylsulfonium Salts.
in Organic letters
McCreanor NG
(2016)
Capture-Collapse Heterocyclization: 1,3-Diazepanes by C-N Reductive Elimination from Rhodacyclopentanones.
in Journal of the American Chemical Society
McGarrigle E
(2018)
Synthesis of Isothiocineole and Application in Multigram-Scale Sulfur Ylide Mediated Asymmetric Epoxidation and Aziridination
in Synthesis
McIntyre CA
(2017)
High-resolution mass spectrometric analysis of myo-inositol hexakisphosphate using electrospray ionisation Orbitrap.
in Rapid communications in mass spectrometry : RCM
Medina S
(2015)
Stereoselective synthesis of glycosides using (salen)Co catalysts as promoters.
in Chemical communications (Cambridge, England)
Medina S
(2016)
Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst.
in Organic letters
Mehrban N
(2014)
Assessing cellular response to functionalized a-helical peptide hydrogels.
in Advanced healthcare materials
Mehrban N
(2015)
Functionalized a-Helical Peptide Hydrogels for Neural Tissue Engineering.
in ACS biomaterials science & engineering
Meng Z
(2017)
Patterning of L10 FePt nanoparticles with ultra-high coercivity for bit-patterned media.
in Nanoscale
Messinis A
(2018)
The highly surprising behaviour of diphosphine ligands in iron-catalysed Negishi cross-coupling
in Nature Catalysis
Metters O
(2016)
Catalytic Dehydrocoupling of Amine-Boranes using Cationic Zirconium(IV)-Phosphine Frustrated Lewis Pairs
in ACS Catalysis
Metters OJ
(2014)
Generation of aminoborane monomers RR'N=BH2 from amine-boronium cations [RR'NH-BH2L](+): metal catalyst-free formation of polyaminoboranes at ambient temperature.
in Chemical communications (Cambridge, England)
Metters OJ
(2016)
Small Molecule Activation by Intermolecular Zr(IV)-Phosphine Frustrated Lewis Pairs.
in Journal of the American Chemical Society
Mills B
(2019)
Tipping the polaron-bipolaron balance: concentration and spin effects in doped oligo(aniline)s observed by UV-vis-NIR and TD-DFT
in Molecular Systems Design & Engineering
Mills BM
(2016)
Exploring Redox States, Doping and Ordering of Electroactive Star-Shaped Oligo(aniline)s.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Millán A
(2016)
Tandem Allylboration-Prins Reaction for the Rapid Construction of Substituted Tetrahydropyrans: Application to the Total Synthesis of (-)-Clavosolide A.
in Angewandte Chemie (International ed. in English)
Millán A
(2018)
Stereocontrolled Synthesis of Polypropionate Fragments based on a Building Block Assembly Strategy using Lithiation-Borylation Methodologies.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Mohammad HH
(2018)
Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway.
in Chembiochem : a European journal of chemical biology
Mohiti M
(2014)
Asymmetric addition of chiral boron-ate complexes to cyclic iminium ions
in Chem. Sci.
Mooibroek TJ
(2016)
A threading receptor for polysaccharides.
in Nature chemistry
Mooibroek TJ
(2016)
Synthesis and evaluation of a desymmetrised synthetic lectin: an approach to carbohydrate receptors with improved versatility.
in Organic & biomolecular chemistry
Mora NL
(2016)
Targeted anion transporter delivery by coiled-coil driven membrane fusion.
in Chemical science
Morris C
(2019)
A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides.
in Advanced functional materials
Murphy A
(2014)
Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390
in Chem. Sci.
Murray P
(2013)
A Robust First-Pass Protocol for the Heck-Mizoroki Reaction
in Organic Process Research & Development
Musgrave R
(2015)
Tuning the Polymerization Behavior of Silicon-Bridged [1]Ferrocenophanes Using Bulky Substituents
in Organometallics
Musgrave R
(2017)
Main-chain metallopolymers at the static-dynamic boundary based on nickelocene
in Nature Chemistry
Musgrave RA
(2018)
New reactivity at the silicon bridge in sila[1]ferrocenophanes.
in Dalton transactions (Cambridge, England : 2003)
Mykura RC
(2018)
Investigation of the Deprotonative Generation and Borylation of Diamine-Ligated a-Lithiated Carbamates and Benzoates by in Situ IR spectroscopy.
in Journal of the American Chemical Society
Nancolas B
(2017)
Saccharomyces cerevisiae Atf1p is an alcohol acetyltransferase and a thioesterase in vitro.
in Yeast (Chichester, England)
Natarajan R
(2013)
Tunable porous organic crystals: structural scope and adsorption properties of nanoporous steroidal ureas.
in Journal of the American Chemical Society
Naudin EA
(2022)
From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles.
in Chemical science
Nazemi A
(2016)
Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media.
in Journal of the American Chemical Society
Nazemi A
(2017)
Uniform "Patchy" Platelets by Seeded Heteroepitaxial Growth of Crystallizable Polymer Blends in Two Dimensions.
in Journal of the American Chemical Society
Neto FC
(2016)
Re-investigation of the fragmentation of protonated carotenoids by electrospray ionization and nanospray tandem mass spectrometry.
in Rapid communications in mass spectrometry : RCM
Niwetmarin W
(2018)
(-)-Cytisine: Access to a stereochemically defined and functionally flexible piperidine scaffold.
in Organic & biomolecular chemistry
Noble A
(2016)
Short Enantioselective Total Synthesis of Tatanan A and 3-epi-Tatanan A Using Assembly-Line Synthesis.
in Angewandte Chemie (International ed. in English)
Noble A
(2018)
Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to ?-Amino Boronic Esters.
in Angewandte Chemie (International ed. in English)
Nofiani R
(2018)
Strobilurin biosynthesis in Basidiomycete fungi.
in Nature communications
Nunns A
(2014)
Crystallization-Driven Solution Self-Assembly of µ-ABC Miktoarm Star Terpolymers with Core-Forming Polyferrocenylsilane Blocks
in Macromolecules
O'Brien H
(2018)
Iron-catalysed substrate-directed Suzuki biaryl cross-coupling
in Nature Catalysis
Odachowski M
(2016)
Development of Enantiospecific Coupling of Secondary and Tertiary Boronic Esters with Aromatic Compounds.
in Journal of the American Chemical Society
Oliver AM
(2018)
Scalable Fiber-like Micelles and Block Co-micelles by Polymerization-Induced Crystallization-Driven Self-Assembly.
in Journal of the American Chemical Society
Palo-Nieto C
(2017)
Gold(I)-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals.
in Journal of the American Chemical Society
Palo-Nieto C
(2017)
Cooperative Brønsted Acid-Type Organocatalysis for the Stereoselective Synthesis of Deoxyglycosides.
in The Journal of organic chemistry
Pelšs A
(2018)
Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of ? 12 -Prostaglandin J 3
in Chemistry - A European Journal
Phanumartwiwath A
(2013)
Silyl migrations in D-xylose derivatives: total synthesis of a marine quinoline alkaloid.
in Organic letters
| Description | The new instruments within the Mass Spectrometry Facility now allow in-depth analysis of complex mixtures, the ability to examine the interactions of molecules with other species such as in inorganic complexes or protein-drug complexes, as well as the analysis of high molecular weight species, such as polymers and proteins. The acquisition of these new instruments has allowed us to significantly advance our understanding of specific chemical reactions, as well as to analyze in detail synthetic approaches to naturally occurring scaffolds, which have the potential to lead to novel therapeutic compounds. Cyclohexane based anion carriers are being designed and synthesized, which may have the potential for channel replacement therapy in cases of cystic fibrosis, synthetic scaffolds are finding applications as medicinal sensors, while rationally designed porous solids are a potential solution to the gas storage problem. The properties of non-proteinogenic amino acids are also of interest, especially those features, which make them suitable for the study of Alzheimer's disease. Scaffolds are being designed with the purpose of supporting cell or tissue growth, enzymes are being rationally developed to act as specific catalysts, while compounds that can mimic biological boundaries could be used as protocells for drug delivery. |
| Exploitation Route | Findings from mass spectrometric analyses carried out will advance mechanistic understanding which will enable the production of new materials. The rational design of compounds which may play a role in energy harvesting and storage, or which may act as drugs with potential healthcare uses will also stimulate research both within academia as well as industry. We are training the current cohorts of PhD students from the Centres for Doctoral training as well as post doctoral researchers within individual groups. These students may eventually progress to senior positions in academia or industry. Output from the MS facility is also being used in undergraduate teaching as well as outreach events with the aim of inspiring the next generation of chemists. |
| Sectors | Chemicals Education Energy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | Chemistry departments within UK universities make significant contributions to worldwide societal challenges through impacts based in drug discovery, energy and new materials. The School of Chemistry at the University of Bristol is an acknowledged leader in synthesis, materials and supramolecular chemistry, as well as chemical biology and research groups are working towards the production of bioactive compounds, polymeric materials and surfactants with applications in energy harvesting and storage, as well as on synthetic receptors with future healthcare potential. Cutting-edge analytical equipment underpins progress in all of these research areas and impacts arising from investment in Mass Spectrometry will broadly fall into four groups: in industry and academia as well as on the general public and society. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Education,Energy,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural Societal Economic |
| Description | ABEL |
| Amount | € 2,467,844 (EUR) |
| Funding ID | LS9,ERC-2013-ADG |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 02/2014 |
| End | 01/2019 |
| Description | AMR Collaborative grant - Exploring Nature's Silent Pharmacy |
| Amount | £2,400,000 (GBP) |
| Funding ID | MR/N029909/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | BIOMOLECULAR ORIGAMI |
| Amount | £333,189 (GBP) |
| Funding ID | BB/M005615/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 08/2017 |
| Description | BP/EPSRC iCASE: Analysis of complex petrochemical deposits. |
| Amount | £80,670 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | Cobalt- and Nickel-based Polymetallocenes: Functional Metallopolymers from Earth-Abundant Metals |
| Amount | £263,683 (GBP) |
| Funding ID | EP/N030702/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2018 |
| Description | Dynamic communication through reorganisable hydrogen bond networks |
| Amount | £195,989 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2019 |
| Description | ERC FRESCO |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 670668 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2015 |
| End | 10/2020 |
| Description | Factory in a Fumehood: Reagentless Flow Reactors as Enabling Techniques for Manufacture |
| Amount | £940,746 (GBP) |
| Funding ID | EP/L003325/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 02/2017 |
| Description | Fellowship David Tilly |
| Amount | £121,492 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Impact acceleration |
| Amount | £68,205 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | LoLa |
| Amount | £3,484,653 (GBP) |
| Funding ID | BB/M002969/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2019 |
| Description | Longer and Larger Grants |
| Amount | £3,500,000 (GBP) |
| Funding ID | BB/K002341/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 07/2018 |
| Description | MRC CiC, Cancer Research Technology and Guy Newton Translational Grant. IGF2-TRAP development. |
| Amount | £130,424 (GBP) |
| Funding ID | BRR00040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 07/2017 |
| Description | Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism |
| Amount | £724,553 (GBP) |
| Funding ID | EP/N024117/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2019 |
| Description | Optoelectronic Nanostructures via Polythiophene Block Copolymer Self-Assembly |
| Amount | £544,263 (GBP) |
| Funding ID | EP/K017799/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 03/2017 |
| Description | Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture |
| Amount | £6,486,390 (GBP) |
| Funding ID | EP/P013341/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2022 |
| Description | Protolife-inspired materials chemistry |
| Amount | £675,541 (GBP) |
| Funding ID | EP/L002957/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 06/2017 |
| Description | Quaternary amino acids on scale for medicine and agroscience |
| Amount | £104,109 (GBP) |
| Funding ID | 727296 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 08/2016 |
| End | 03/2019 |
| Description | SAGE |
| Amount | £731,565 (GBP) |
| Funding ID | BB/L010518/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2017 |
| Description | Synthesis and Biology of Prostanoids |
| Amount | £1,061,277 (GBP) |
| Funding ID | EP/M012530/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 04/2020 |
| Description | Synthetic Biology |
| Amount | £13,528,180 (GBP) |
| Funding ID | BB/L01386X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2019 |
| Description | The Ironworks: a mechanistic foundry for iron-catalysed cross-coupling |
| Amount | £630,649 (GBP) |
| Funding ID | EP/K012258/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 07/2017 |