Core Capability for Chemistry Research - Strategic Investment in Mass Spectrometry
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
See Case for Support and Pathways to Impact
Planned Impact
Attached as separate document.
Organisations
Publications
Wang GW
(2016)
New Initiation Modes for Directed Carbonylative C-C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes.
in Journal of the American Chemical Society
Wang H
(2017)
Conjugated Microporous Polycarbazole Networks as Precursors for Nitrogen-Enriched Microporous Carbons for CO 2 Storage and Electrochemical Capacitors
in Chemistry of Materials
Wang L
(2018)
A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis
in Nature Catalysis
Wang Y
(2017)
Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans.
in Angewandte Chemie (International ed. in English)
Wang Y
(2016)
Enantiospecific Alkynylation of Alkylboronic Esters.
in Angewandte Chemie (International ed. in English)
Warren AD
(2016)
Investigation of colloidal graphite as a matrix for matrix-assisted laser desorption/ionisation mass spectrometry of low molecular weight analytes.
in Journal of mass spectrometry : JMS
Warren AD
(2018)
Methodologies for the airbrush application of MALDI matrices.
in European journal of mass spectrometry (Chichester, England)
Wasil Z
(2013)
One pathway, many compounds: heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity
in Chemical Science
Watkins DW
(2017)
Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme.
in Nature communications
Watson C
(2014)
Lithium Compounds in Organic Synthesis
Watson CG
(2013)
Asymmetric synthesis of 1-heteroaryl-1-arylalkyl tertiary alcohols and 1-pyridyl-1-arylethanes by lithiation-borylation methodology.
in Organic letters
Watson CG
(2014)
Construction of multiple, contiguous quaternary stereocenters in acyclic molecules by lithiation-borylation.
in Journal of the American Chemical Society
Watt MS
(2016)
Palladium(II) Catalyzed C-H Functionalization Cascades for the Diastereoselective Synthesis of Polyheterocycles.
in Organic letters
Wattana-Amorn P
(2013)
Biosynthetic origins of menisporopsin A.
in Journal of natural products
Wechsel R
(2016)
The meso Helix: Symmetry and Symmetry-Breaking in Dynamic Oligourea Foldamers with Reversible Hydrogen-Bond Polarity.
in Angewandte Chemie (International ed. in English)
Weinberg K
(2013)
Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds
in Tetrahedron
Williams K
(2017)
Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis.
in Chemical communications (Cambridge, England)
Williams K
(2016)
Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis.
in Angewandte Chemie (International ed. in English)
Wilson CM
(2017)
Enantiospecific sp2 -sp3 Coupling of ortho- and para-Phenols with Secondary and Tertiary Boronic Esters.
in Angewandte Chemie (International ed. in English)
Wingad R
(2015)
Catalytic Conversion of Ethanol to n -Butanol Using Ruthenium P-N Ligand Complexes
in ACS Catalysis
Winter AJ
(2018)
The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA.
in The Journal of biological chemistry
Wolny M
(2017)
Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability.
in Scientific reports
Wu J
(2018)
Photoinduced Deaminative Borylation of Alkylamines.
in Journal of the American Chemical Society
Wu L
(2017)
Non-Metal-Catalyzed Heterodehydrocoupling of Phosphines and Hydrosilanes: Mechanistic Studies of B(C6F5)3-Mediated Formation of P-Si Bonds.
in Journal of the American Chemical Society
Yu WL
(2018)
Short, Gram-Scale Syntheses of ß- and ?-Lycorane Using Two Distinct Photochemical Approaches.
in Organic letters
Zawodny W
(2018)
Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement.
in Journal of the American Chemical Society
Zhou H
(2016)
PFS- b -PNIPAM: A First Step toward Polymeric Nanofibrillar Hydrogels Based on Uniform Fiber-Like Micelles
in Macromolecules
Zhurakovskyi O
(2018)
Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides.
in Angewandte Chemie (International ed. in English)
Zhurakovskyi O
(2018)
Stereo- and Regiocontrolled Methylboration of Terminal Alkynes.
in Organic letters
Zieleniewski F
(2020)
Automated solid-phase concatenation of Aib residues to form long, water-soluble, helical peptides.
in Chemical communications (Cambridge, England)
| Description | The new instruments within the Mass Spectrometry Facility now allow in-depth analysis of complex mixtures, the ability to examine the interactions of molecules with other species such as in inorganic complexes or protein-drug complexes, as well as the analysis of high molecular weight species, such as polymers and proteins. The acquisition of these new instruments has allowed us to significantly advance our understanding of specific chemical reactions, as well as to analyze in detail synthetic approaches to naturally occurring scaffolds, which have the potential to lead to novel therapeutic compounds. Cyclohexane based anion carriers are being designed and synthesized, which may have the potential for channel replacement therapy in cases of cystic fibrosis, synthetic scaffolds are finding applications as medicinal sensors, while rationally designed porous solids are a potential solution to the gas storage problem. The properties of non-proteinogenic amino acids are also of interest, especially those features, which make them suitable for the study of Alzheimer's disease. Scaffolds are being designed with the purpose of supporting cell or tissue growth, enzymes are being rationally developed to act as specific catalysts, while compounds that can mimic biological boundaries could be used as protocells for drug delivery. |
| Exploitation Route | Findings from mass spectrometric analyses carried out will advance mechanistic understanding which will enable the production of new materials. The rational design of compounds which may play a role in energy harvesting and storage, or which may act as drugs with potential healthcare uses will also stimulate research both within academia as well as industry. We are training the current cohorts of PhD students from the Centres for Doctoral training as well as post doctoral researchers within individual groups. These students may eventually progress to senior positions in academia or industry. Output from the MS facility is also being used in undergraduate teaching as well as outreach events with the aim of inspiring the next generation of chemists. |
| Sectors | Chemicals Education Energy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | Chemistry departments within UK universities make significant contributions to worldwide societal challenges through impacts based in drug discovery, energy and new materials. The School of Chemistry at the University of Bristol is an acknowledged leader in synthesis, materials and supramolecular chemistry, as well as chemical biology and research groups are working towards the production of bioactive compounds, polymeric materials and surfactants with applications in energy harvesting and storage, as well as on synthetic receptors with future healthcare potential. Cutting-edge analytical equipment underpins progress in all of these research areas and impacts arising from investment in Mass Spectrometry will broadly fall into four groups: in industry and academia as well as on the general public and society. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Education,Energy,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural Societal Economic |
| Description | ABEL |
| Amount | € 2,467,844 (EUR) |
| Funding ID | LS9,ERC-2013-ADG |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 02/2014 |
| End | 01/2019 |
| Description | AMR Collaborative grant - Exploring Nature's Silent Pharmacy |
| Amount | £2,400,000 (GBP) |
| Funding ID | MR/N029909/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | BIOMOLECULAR ORIGAMI |
| Amount | £333,189 (GBP) |
| Funding ID | BB/M005615/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 08/2017 |
| Description | BP/EPSRC iCASE: Analysis of complex petrochemical deposits. |
| Amount | £80,670 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | Cobalt- and Nickel-based Polymetallocenes: Functional Metallopolymers from Earth-Abundant Metals |
| Amount | £263,683 (GBP) |
| Funding ID | EP/N030702/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2018 |
| Description | Dynamic communication through reorganisable hydrogen bond networks |
| Amount | £195,989 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2019 |
| Description | ERC FRESCO |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 670668 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2015 |
| End | 10/2020 |
| Description | Factory in a Fumehood: Reagentless Flow Reactors as Enabling Techniques for Manufacture |
| Amount | £940,746 (GBP) |
| Funding ID | EP/L003325/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 02/2017 |
| Description | Fellowship David Tilly |
| Amount | £121,492 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Impact acceleration |
| Amount | £68,205 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | LoLa |
| Amount | £3,484,653 (GBP) |
| Funding ID | BB/M002969/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2019 |
| Description | Longer and Larger Grants |
| Amount | £3,500,000 (GBP) |
| Funding ID | BB/K002341/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 07/2018 |
| Description | MRC CiC, Cancer Research Technology and Guy Newton Translational Grant. IGF2-TRAP development. |
| Amount | £130,424 (GBP) |
| Funding ID | BRR00040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 07/2017 |
| Description | Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism |
| Amount | £724,553 (GBP) |
| Funding ID | EP/N024117/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2019 |
| Description | Optoelectronic Nanostructures via Polythiophene Block Copolymer Self-Assembly |
| Amount | £544,263 (GBP) |
| Funding ID | EP/K017799/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 03/2017 |
| Description | Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture |
| Amount | £6,486,390 (GBP) |
| Funding ID | EP/P013341/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2022 |
| Description | Protolife-inspired materials chemistry |
| Amount | £675,541 (GBP) |
| Funding ID | EP/L002957/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 06/2017 |
| Description | Quaternary amino acids on scale for medicine and agroscience |
| Amount | £104,109 (GBP) |
| Funding ID | 727296 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 08/2016 |
| End | 03/2019 |
| Description | SAGE |
| Amount | £731,565 (GBP) |
| Funding ID | BB/L010518/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2017 |
| Description | Synthesis and Biology of Prostanoids |
| Amount | £1,061,277 (GBP) |
| Funding ID | EP/M012530/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 04/2020 |
| Description | Synthetic Biology |
| Amount | £13,528,180 (GBP) |
| Funding ID | BB/L01386X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2019 |
| Description | The Ironworks: a mechanistic foundry for iron-catalysed cross-coupling |
| Amount | £630,649 (GBP) |
| Funding ID | EP/K012258/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 07/2017 |