OCEAN: One-stop-shop microstructure-sensitive perfusion/diffusion MRI: Application to vascular cognitive impairment

Lead Research Organisation: University of Sheffield
Department Name: Electronic and Electrical Engineering

Abstract

The term "dementia" is used to describe a syndrome that results, initially, in cognitive function impairment and in many cases, a descending staircase of psychological dysfunction, leading eventually to death.
It is a major socio-economic challenge with care costs approaching 1% of global GDP. Several conditions that lead to serious loss of cognitive ability are grouped under this syndrome, including Alzheimer's disease (AD), Vascular Dementia (VaD), Frontotemporal Dementia, etc. A high publicity announcement was made in 2012, by the Prime Minister, emphasising the high priority that should be given to dementia-related research and that funding will more than double in the immediate future, to partially remedy the fact that the overwhelming impact of the syndrome has been over-looked (Guardian, 26/3/12). On Dec 2013, the G8 Summit hosted in London brought together G8 ministers, researchers, pharmaceutical companies, and charities to develop co-ordinated global action on dementia.

Dementia has marked adverse effects on the quality of life of tens of millions of people (both patients and carers) and exerts tremendous pressure on healthcare systems, especially when clear trends towards an ageing population, changing environmental influences and contemporary lifestyle choices are considered. Ca. 35M people suffer from dementia worldwide, a figure to quadruple by 2050. Europe and North America share a disproportionally high burden: the effects of ageing are particularly stark for these regions, exacerbating the healthcare provision implications.

The Clinical Relevance: Vascular Cognitive Impairment (VCI). VCI defines alterations in cognition attributable to cerebrovascular causes, ranging from subtle or fixed deficits to full-blown dementia. VCI is a wide and accepted term referring to the "syndrome with evidence of clinical stroke or subclinical vascular brain injury and cognitive impairment affecting at least one cognitive domain", with resulting VaD being its most severe form. VaD is responsible for at least 20% of dementias, second only to AD, with a prevalence doubling every 5. 3 years. Several trials examined cholinesterase inhibitors for the treatment of vascular dementia, but the benefits are very modest, except in the individuals with a combination of AD and VaD. Vascular changes result in white matter (WM) damage (leukoaraiosis), which profoundly affect the fidelity of the information transfer underlying brain function and cognitive health8.

Cerebral Magnetic Resonance Imaging (MRI) of Diffusion and Perfusion. MRI is a medical imaging technique affording non-invasive investigation of anatomy and tissue function, which is particularly suited to studying cognitive disorders due to its sensitivity and reliability. Our main interest is to characterise vascular and non-vascular tissues using quantitative diffusion and perfusion MR. Our overall aim is to characterise and quantify early differential alterations in brain blood transport and subsequent microstructural tissue damage using one-stop-shop perfusion/diffusion MR GSI incorporating novel MR signal models and optimal MR sequence design based on new human brain histomorphometric data in health and disease.

Planned Impact

Dementia already is one of society's biggest medical challenges. No cures are so far available. Yet, research is intense and strong candidate therapies are on the horizon. Given the variety of causes and aetiologies of dementia, reliable identification of the underlying pathologies is a requisite for therapy effectiveness. Differential diagnosis is therefore key. Effectiveness, also, is greatly modulated by the level of disease progression in individuals. Even where outright cure is unrealistic, evidence already suggests that lifestyle changes and other treatments can delay the progression of symptoms, provided these are identified sufficiently early. This is of enormous significance to sufferers and their families. Societal economic implications aside, the quality of life benefits for sufferers from prolonged independence, and the emotional and financial alleviation for families and carers are substantial. Early diagnosis is therefore key. It is in the provision of differential and early diagnosis that the technologies developed within OCEAN can have a serious impact.

Knowledge management and exchange with other key EU-, RCUK- and NIHR-funded initiatives. To maximise synergies with other relevant initiatives and ensure knowledge cross-fertilisation, we set up a Scientific Advisory Board (SAB) experienced in relevant engineering and physical sciences and with a track record of clinical translation of research results. This cadre of academics includes world class scientists in the areas of MR diffusion imaging, medical image computing, and computational modelling.

Industrial engagement and commercial take-up. Several companies are committed to OCEAN thus incorporating a technological and exploitation dimension from the outset of the project. Companies were selected to cover all key areas and technologies in OCEAN where exploitable outcomes or collaborations are anticipated; previous or ongoing research collaborations were also accounted. Statements of support are appended.
Microscopy data will be made available to community. OCEAN is committed to making the multimodal image database of light and electron microscopy and 7T MRI brain tissue data available online by the end of the project. We shall also make available the quantitative statistics of microstructural composition and properties. Access to this unique resource will be made online via a project portal built and
managed jointly by SITraN and CISTIB-INSIGNEO.

MR GSI Image Analysis & Visualisation Tool. Once validation of the modelling methodologies has taken place, these tools will be made available to the wider clinical and research community. We plan to prototype an MR GSI Image Analysis & Visualisation Tool based on GIMIAS (www.gimias.org), an open-source platform developed at CISTIB.

From proof of principle and feasibility to demonstration of clinical impact. Once we have established the feasibility of MR GSI and evaluated it in simulation, phantom studies and short series of volunteers, we will seek follow-up funding streams to conduct a clinical proof-of-concept in a large cohort. This will be designed to assess the effectiveness of MR GSI for early detection of VCI-related disorders and, importantly, the differentiation of pathological mechanisms that is essential for therapy formulation.

Engaging patient and public in research through the Dementia Public and Patient Involvement (PPI) group. We have partnered with the Alzheimer's Society, which will contribute two volunteers in our Scientific and Clinical Advisory Boards, respectively. Funds have been set apart according to the INVOLVE guidance to facilitate the participation of these volunteers.

Publications

10 25 50

Related Projects

Project Reference Relationship Related To Start End Award Value
EP/M006328/1 31/03/2015 31/07/2018 £1,302,402
EP/M006328/2 Transfer EP/M006328/1 01/11/2018 30/06/2019 £58,452
 
Description We developed a computational framework for simulation of diffusion MRI data and for the generation of realistic models of white matter. This will allow performing sensitivity analysis of diffusion MRI to changes in the white matter due to vascular dementia.

We have developed a more robust method to simultaneously estimate diffusion and perfusion directional properties in brain white matter from MRI.

We have generated a database of histological images of deep white matter from 90 human subjects from an aging population. This database is stratified in 3 group of 30 subject each according to the presence of subcortical lesion. For each subject, four components have been imaged: axons, mieline, astrocytes, and capillaries. This database has already anable obtaining statistical characterizations of several features of those components in the population. More analysis are currently being carried. This will enable the generation of more specific microstructural models for the analysis of diffusion MRI, and a more specific diagnosis of subcortical lesions in dementia.

We have also understood the fundamental cause of the degeneration of existing models like NODDI and NODDIDA. We have proposed solutions to this problem and this led to new MRI schemes to sample the space of diffusion orientations.
Exploitation Route The outcomes of this funded program, to be translated to the clinical environment, would need a follow up grant to streamline the process, develop clinical MR acquisition protocols, and accelerated acquisitions. Some of this work will be done in the context of a follow up Marie Curie Innovative Training Network (BQ-MINDED). We will also explore the proposed techniques and their transfer to cardiology and musculoskeletal diseases.
Sectors Education,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description The project has led to a collaboration with a company in the Sheffield area that develops advanced data sharing middlewares. We created a joint video explaining, in lay terms, the impact of this technology and our group's research in this context. The video is available: https://www.youtube.com/watch?v=VG8lSGWIbY0&list=PLup8cbzcK-NOf4ZTeYNJhPq_dmvl42_ot The work has also led to the training of a PhD student, Santiago Coelho https://ethos.bl.uk/OrderDetails.do?did=2&uin=uk.bl.ethos.798018 who performed a visit to the group of Dimitry Novikov https://med.nyu.edu/faculty/dmitry-novikov in NYU Langone Health. Santiago is now doing a postdoctoral stay in that group.
First Year Of Impact 2019
Sector Healthcare
Impact Types Societal,Economic

 
Description Strategic research agenda for biomedical imaging.
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact This Strategic Research Agenda identifies current challenges and needs in healthcare, illustrates how biomedical imaging and derived data can help to address these, and aims to stimulate dedicated research funding efforts.Medicine is currently moving towards a more tailored, patient-centric approach by providing personalised solutions for the individual patient. Innovation in biomedical imaging plays a key role in this process as it addresses the current needs for individualised prevention, treatment, therapy response monitoring, and image-guided surgery.The use of non-invasive biomarkers facilitates better therapy prediction and monitoring, leading to improved patient outcomes. Innovative diagnostic imaging technologies provide information about disease characteristics which, coupled with biological, genetic and -omics data, will contribute to an individualised diagnosis and therapy approach.In the emerging field of theranostics, imaging tools together with therapeutic agents enable the selection of best treatments and allow tailored therapeutic interventions.For prenatal monitoring, the use of innovative imaging technologies can ensure an early detection of malfunctions or disease.The application of biomedical imaging for diagnosis and management of lifestyle-induced diseases will help to avoid disease development through lifestyle changes.Artificial intelligence and machine learning in imaging will facilitate the improvement of image interpretation and lead to better disease prediction and therapy planning.As biomedical imaging technologies and analysis of existing imaging data provide solutions to current challenges and needs in healthcare, appropriate funding for dedicated research is needed to implement the innovative approaches for the wellbeing of citizens and patients.
URL https://www.ncbi.nlm.nih.gov/pubmed/30693378
 
Description Breakthroughs in Quantitative Magnetic resonance ImagiNg for improved DEtection of brain Diseases
Amount € 3,861,067 (EUR)
Funding ID 764513 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2018 
End 12/2021
 
Description Educational Stipend for Students
Amount $450 (USD)
Organisation International Society for Magnetic Resonance in Medicine (ISMRM) 
Sector Charity/Non Profit
Country United States
Start 04/2017 
End 04/2017
 
Description INSILEX: Precision Computational Medicine for \textit{in silico} Trials of Medical Devices
Amount £2,760,000 (GBP)
Funding ID CiET1819/19 
Organisation Royal Academy of Engineering 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 04/2029
 
Description Learned Society Fund 16/17 - Funding for conference/workshop attendance
Amount £500 (GBP)
Organisation University of Sheffield 
Department Learned Societies Fund (University of Sheffield)
Sector Charity/Non Profit
Country United Kingdom
Start 04/2017 
End 04/2017
 
Description OCEAN: One-stop-shop microstructure-sensitive perfusion/diffusion MRI: Application to vascular cognitive impairment
Amount £58,452 (GBP)
Funding ID EP/M006328/2 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 06/2019
 
Title Algorithm for the statistical analysis of the axonal orientation distribution in 3D from histological images of 2D slices. 
Description Algorithm for the statistical analysis of the axonal orientation distribution in 3D from histological images of 2D slices. This algorithm allows testing statistically the agreement of axonal 2D histological images in windows of observation of different scales with a particular class of 3D orientation distributions. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? No  
Impact This algorithm is a crucial part of two journal paper in preparation. This papers will allow to confirm or falsify whether some proposed 3D orientation distribution proposed in micro-structural model for the analysis of diffusion MRI are appropriate. 
 
Title Histological images of axons, mieline, astrocites, and colagen, from 30+30+30 subjects. 
Description Histological images of axons, mieline, astrocites, and colagen, from 90 aging human subjects, stratified in 3 groups of 30 subjects each according to the presence of subcortical lesion. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact This database is the basis for several papers already submitted or in preparation. They will provide statiscal information on the distribution of several features characterizing each the 4 component (axons, mieline, astrocites, and colagen) in an aging human population. This will anable the generation of more specific microstructural models for the analysis of diffusion MRI, and a more specific diagnosis of subcortical lesions in dementia. 
 
Title Microstructure MRI signal model for double-direction diffusion encoding. 
Description A new diffusion MRI protocol involving two sequential gradient directions for a single signal detection (double-direction diffusion encoding). Based on that the corresponding MRI signal model has been developed. A estimation algorithm has been developed and implemented for the generalization of the microstructural NODDI model to double-direction diffusion encoding. 
Type Of Material Computer model/algorithm 
Provided To Others? No  
Impact This new protocol is expected to improve the robustness and accuracy of the quantification of the microstructural characteristics of white matter from MRI, reducing the required acquisition time. 
 
Title Scanned Tissue Database. Univeristy of Sheffield. 
Description OCEAN is committed to making the multimodal image database of light and electron microscopy and 7T MRI brain tissue data available online by the end of the project. We shall also make available the quantitative statistics of microstructural composition and properties. Access to this unique resource will be made online via a project portal built and managed jointly by SITraN and CISTIB. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact Initial version of the database with an initial set of data acquired is currently available for internal validation and verification by CISTIB AND SITRaN teams 
 
Title Semi-automatic method for the quantification of microglial inflamation from histological images. 
Description Semi-automatic method for the quantification of microglial inflamation from histological images. This allows quantifying the status of lessions in human brain subcortical deep white matter. It is a crucial element of journal paper in preparation. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? No  
Impact This method allows quantifying the status of lessions in human brain subcortical deep white matter. It is a crucial element of journal paper in preparation. It can also open new collaboration applying the method to different structures and disseases. This is being explored. 
 
Title Statistical distribution of volume fractions in deep white matter of axons, mielinated axons, and astrocites. 
Description Statistical distribution of volume fractions in deep white matter of axons, mielinated axons, and astrocites. The statistical distribution in an aging population has been computed from histological images of deep white matter from 90 human subjects stratified in 3 group of 30 subject each according to the presence of subcortical lesion. The statistical distributions is also accordingly stratified in these 3 groups: lesion, normal appearing white matter, and control. This includes the quantification of statistical differences between the 3 groups. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact This database is a crucial element of the journal paper Coehlo S, Pozo J M, Costantini M, Highley J R, Mozumder M, Simpson J E, Ince P G, Frangi A F (2018), "Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter". NeuroImage (submitted). 
 
Description 2015 Diffusion UK meeting. University of Sheffield 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This meeting drew together researchers from the field of diffusion MRI. This included academics and PhD students from different institutes within the UK and Ireland. The day included poster and talks given by both senior academics and junior researchers working on the characterisation brain microstructure by means of diffusion MRI. The event was held in the Graduate Teaching Building of the Faculty of Engineering at the University of Sheffield (www.sheffield.ac.uk/faculty/engineering). The meeting had a particular focus on the use of dMRI for finding early biomarkers of neurodegenerative diseases. Presenters included Marc Jones (KCL), Fenglei Zhou (Manchester University), Jonathan Clayden (UCL), Jacques-Donald Tournier (KCL), and Andrada Ianus (UCL). The event had approximately 50 participants either presenting posters or attending the event. The day was led by Leandro Beltrachini (CISTIB, The University of Sheffield). The event was a success, the excellent attendance and the quality of the posters and the presentations were engaging and explored the facets of diffusion MRI. The meeting allowed the attendees to exchange of ideas and the fostering of future collaborations.
Year(s) Of Engagement Activity 2015
URL http://www.ocean-mri.org/index.php/news/diffusion-uk-meeting
 
Description British Institute of Radiology Annual Conference - Machine learning for automated reporting using big data, Dr Ali Gooya 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Ali Gooya from the University of Sheffield gave a plenary talk at BIR AC 2016 entitled Machine learning for automated reporting using big data. The main goal was to increase awareness on the role of Machine Learning and Deep Learning in automated medical image analysis and reporting. The audience was very interested in this domain and a number of follow up activities in the network in this space have followed.
Year(s) Of Engagement Activity 2006
URL https://www.bir.org.uk/education-and-events/annual-congress-2016/
 
Description Development o the physical phantom (Project Meeting) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Nine members of the project from Sheffield and Manchester met to discuss project progress as well to agree on the plan for the development of the physical phantom and explore other opportunities for collaboration
Year(s) Of Engagement Activity 2015
URL http://www.qbi-lab.org/
 
Description IEEE Trans Med Imaging: Special Issue on Simulation and Synthesis in Medical Image Analysis 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This special issue and accompanying editorial in one of the top journals of our field, introduces the Special Issue on Simulation and Synthesis in Medical Imaging. This special issue was run between Prof AF Frangi and Dr S Tsaftaris (both from UK) and Prof JL Prince (from Johns Hopkins University). In this editorial, we define so-far ambiguous terms of simulation and synthesis in medical imaging. We also briefly discuss the synergistic importance of mechanistic (hypothesis- driven) and phenomenological (data-driven) models of medical image generation. Finally, we introduce the twelve papers published in this issue covering both mechanistic (5) and phenomenological (7) medical image generation. This rich selection of papers covers applications in cardiology, retinopathy, histopathology, neurosciences, and oncology. It also covers all mainstream diagnostic medical imaging modalities. We conclude the editorial with a personal view on the field and highlight some existing challenges and future research opportunities.
Year(s) Of Engagement Activity 2018
URL https://ieee-tmi.org/fast-facts/featured-article.asp?id=28&title=Special-Edition:-Simulation-and-Syn...
 
Description Importance of benchmarking in medical image analysis and related pitfalls 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International challenges have become the standard for validation of biomedical image analysis methods. Given their scientific impact, it is surprising that a critical analysis of common practices related to the organization of challenges has not yet been performed. In this paper, we present a comprehensive analysis of biomedical image analysis challenges conducted up to now. We demonstrate the importance of challenges and show that the lack of quality control has critical consequences. First, reproducibility and interpretation of the results is often hampered as only a fraction of relevant information is typically provided. Second, the rank of an algorithm is generally not robust to a number of variables such as the test data used for validation, the ranking scheme applied and the observers that make the reference annotations. To overcome these problems, we recommend best practice guidelines and define open research questions to be addressed in the future.
Year(s) Of Engagement Activity 2016,2017
 
Description Kick-Off Meeting. University of Sheffield 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Formal Kick-off meeting attended by all PIs, with the following agenda.

10:00am Welcome, domestics
10:05am Introduction round
10:20am OCEAN: Vision and Overview
10:35am Vascular dementia and the clinical relevance of OCEAN
10:50am Pathology and histology in OCEAN
11:05am Overview of CUBRIC and contributions to OCEAN
11:20am Biomimetic phantom development: update and plans
11:30am CISTIB Update on microstructure and numeric model development
11:45am Discussion and identification of actions to follow on
- Identify critical items requiring further discussion
12:15am General coordination and next steps
- Histology protocol internal draft, draft to Adv Board
- Biomimetic phantom specification: visit to Manchester
- Visit to CUBRIC: possibilities of experimental set ups
- Other actions emerging from the meeting

- Meeting with stakeholders (Industry, Alz Soc, Adv Board)
- Updated on job advertisements and recruitment
- Institutional Agreements Status

12:30am Conclusions & Meeting Close
Year(s) Of Engagement Activity 2015
URL http://www.ocean-mri.org/
 
Description Medical Image Computing and COmputer Assisted Interventions 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Alejandro Frangi is General Chair of MICCAI 2018, the premier international conference in Medical Image Analysis. Several other members of MedIAN contribute this year too: Julia Schnabel as Program Chair, Dan Stoyanov as Workshop Chair, Zeike Taylor as Workshop Co-Chair, etc. This conference has been an opportunity for MedIAN to provide leadership to the community and international exposure.
Year(s) Of Engagement Activity 2018
URL http://www.miccai2018.org
 
Description Meeting in CUBRIC (Cardiff) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Visit to Derek Jones's group and the new national facilities to evaluate technical progress in the project and identify additional collaborations
Year(s) Of Engagement Activity 2016
URL http://sites.cardiff.ac.uk/cubric/
 
Description Meeting in Lisbon at the Champalimaud centre for the unknown 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Visit to Noam Shemesh's group to identify new collaborations with key centres/research groups in Europe. Established preliminary lines of collaboration in the lines of this project. Got extremely valuable comments related to the histology protocol
Year(s) Of Engagement Activity 2016
URL http://neuro.fchampalimaud.org/en/research/investigators/research-groups/group/Shemesh/
 
Description Meeting with Dr Jan Sijbers' group (Virtual) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Virtual meeting with Dr Jan Sijbers' group (Vision Lab, University of Antwerp, Antwerpen, Belgium) for finding new collaborations between the research groups (fifteen attendees).
Year(s) Of Engagement Activity 2015
URL http://visielab.uantwerpen.be/
 
Description OCEAN General Project Meeting, 16th October 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Synchronization of project activities, planning, and cross-fertilization of research ideas.
Year(s) Of Engagement Activity 2017
 
Description Presentation at the GLIA workshop. University of Sheffield. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Work related to this project (OCEAN) was presented in this workshop aimed to show different angles for studying white matter tissue components. The presentation was entitled "Random generation of white matter models for in silico MRI studies", which is a crucial component of the main proposal (WP. 1). As a result, we established clear links with clinicians working in the field (from both within and outside the University of Sheffield).
Year(s) Of Engagement Activity 2015
URL http://www.ocean-mri.org/
 
Description Project Meeting June 2015 (Virtual) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact project board teleconference with participation of the different institutions to discuss the following topics
14:00 Histology protocol internal draft, draft to Advisory Board
14:15 Biomimetic phantom specification: visit to Manchester
14:25 Visit to CUBRIC: possibilities of experimental set ups
14:35 Agree dates for meeting with stakeholders (Industry, Alz Soc, Adv Board)
14:45 Update on recruitment
14:55 Institutional Agreements Status
15:00 Project website and mailing lists
15:05 AOB
Year(s) Of Engagement Activity 2015
 
Description Project meeting September 2015 (Virtual) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Project meeting attended for different project institutions to discuss project progress

14:00 Welcome
14:05 Review outstanding action from last meeting
14:10 Miscellaneous updates:
1. Recruitment: Sheffield (CISTIB, SITRAN), Manchester.
2. Institutional agreement
3. Members area in website
4. Summary of the visit to Manchester
14:30 Progress to date:
1. Microscopy scanner in place
2. IT issues regarding the scanner / Online access to data
3. Test samples from CFAS
4. Imaging update
14:50 Future events:
1. Next Skype meeting
2. Meeting in Sheffield regarding phantom construction (Sept. 2015)
3. Diffusion UK meeting (Nov. 2015) + stakeholders
4. Meeting in Cardiff (Feb. 2016)
15:10 AOB
Year(s) Of Engagement Activity 2016
 
Description Scientific Advisory Board 2015. University of Sheffield 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The SAB was attended by seventeen people with the agenda below, particularly relevant at this stage was the feedback gathered for the Neuropathology and Imaging Protocol from PB and SAB members: Prof Daniel Alexander(UCL), Dr Jacques-Donald Torunier(KCL), Prof Jonathan Clayden (TUM), Dr Helen Stolp(KCL), Dr Laura Parkes(UOM)

Agenda:
10.00 Introduction Prof Alejandro Frangi
10.10 OCEAN: Progress so far Leandro Beltrachini
10.20 Neuropathology and Imaging protocol Leandro Beltrachini
10.50 Update from Manchester Geoff Parker
11.10 General update on the project "Quantification of vascular and neuronal pathology in dementia using PET and MRI"
11.30 Discussion & Summary
12.00 Lunch
Year(s) Of Engagement Activity 2015
URL http://www.ocean-mri.org/
 
Description UCL Partners AHSC Cardiovasvcular eMedLab Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This meeting had as purpose to bring together people working on the UK Biobank Data specially those with a technical focus working either on image analysis or data management. The group in Sheffield presented the work they are doing on cardiac image analysis and their work on www.multi-x.org. The work was very well received and we have currently a paper on quality assessment that is under review and whose origins could be traced back to discussions in this meeting with QMUL and Oxford colleagues.
Year(s) Of Engagement Activity 2017
URL https://uclpartners.com/events/cardiovascular-emedlab-workshop/