ADVANCED FLOW TECHNOLOGY FOR HEALTHCARE MATERIALS MANUFACTURING

Lead Research Organisation: University College London
Department Name: Chemical Engineering

Abstract

Inorganic nanoparticles have the potential to dramatically modify existing materials while providing the capability to engineer a broad range of transformative new products. Exhibiting unique properties not encountered in bulk materials, inorganic nanoparticles present the opportunity to address, and the potential to overcome, some of the most pressing global challenges. This is leading to intense global competition to develop and commercialize nanoproducts with a variety of applications in healthcare, energy, transport and security, with the aim of acquiring a dominant market position in the nanotechnology sector. Nanoparticles offer ideal solutions for detecting and treating many diseases. They can be used as drug carriers, labelling and tracking agents, and vectors for gene therapy, hyperthermia treatment and magnetic resonance imaging contrast agents. Used as targeted drug-delivery systems, they can improve the performance of medicines already on the market. They enable the development of new therapeutic strategies such as anti-cancer drug delivery, extending product life cycles and reducing healthcare costs. In this proposal we focus on the manufacturing of gold nanoparticles (Au-NPs) and iron oxide magnetic nanoparticles (MNPs). These materials have existing applications in diagnostics and therapeutics. Bespoke monodispersed functionalised NPs offer new applications in antimicrobial surfaces (Au NPs plus dye) and in a new hyperthermia treatment for cancer (MNPs). UCL is at the forefront of the engineering approach to make nanoparticles as well as being world leading in magnetic hyperthermia and antimicrobial surfaces.

Nanoparticles are conventionally synthesized in relatively small batch reactors. These systems are poorly controllable, leading to products that are hard to reproduce. Also, they do not lend themselves to expedient upscaling. Such problems are caused by the inefficient mixing and slow heat and mass transfer characterizing batch reactors, and by the difficulty of decoupling in time the various stages of the synthesis, particularly particle nucleation and growth. This research aims to design and demonstrate a new, sustainable and scalable approach for manufacturing high-value nanomaterials with advanced properties in a way that is controllable and reproducible and that does not involve significant upscaling issues. To attain this ambitious goal, we will integrate methods, skills and strengths of different disciplines (materials chemistry, engineering), seeking guidance from industrial partners and UK manufacturing centres. Giving us access to their state-of-the-art facilities, sharing their expertise and providing an application context for our work, they will further characterize the nanoparticles, evaluate their performance and facilitate pathways to manufacture and routes to market.

There is currently a lot of research in developing novel materials, where the focus is on discovery but with little emphasis on manufacturing. Using chemical engineering principles and systems engineering methodologies within a multidisciplinary framework, our research will demonstrate not only the need to consider key physical phenomena (mixing, heat transfer etc.) in nanoparticles synthesis, but also how to account and address related manufacturing challenges from the outset. In this way, an important benefit of this project will be to provide a paradigm shift in nanoparticle synthesis and production and bridge the discovery-manufacturing divide.

Planned Impact

Impact on economy. Nanotechnologies are important to the UK future because of their potential to improve, if not altogether transform, many types of consumer products. The worldwide transition toward the use of nanotechnologies is a significant economic opportunity for the UK. In healthcare, nano-enabled drug delivery is expected to grow from a current value of $2.3 billion to $136 billion by 2021, while nano-enabled diagnostics is estimated to reach $53 billion by 2021. This work will contribute to keeping the UK at the forefront of nanotechnology by enhancing UK's strategic manufacturing capability. Although the research focuses on healthcare applications, our technology will have wide applicability and impact, and will naturally translate to other manufacturing sectors. The nanotechnology industry in general will thus benefit from this work. Our approach will help reduce risk and capital cost associated with scaling up, by eliminating costly redesigns and pilot plant experiments.

Impact on society. In the long term, the health and life quality of the wider public will benefit through the provision of more efficient and less harmful diagnostic and therapeutic techniques enabled by the use of the nanomaterials that this research aims to manufacture. Nanoparticles offer the opportunity to radically change how we prevent, diagnose and treat diseases through ground-breaking advances in targeted and time-controlled drug delivery, radiotherapy, cancer treatment and regenerative tissue engineering. However, to make this vision a reality, we need to engineer robust and scalable processes able to manufacture NPs consistently and with the desired throughput. This research will enable us to achieve this, contributing to making such products viable to the general public. Should this technology become established and readily available, it will greatly benefit the society at large, improving life-quality and life-expectancy.

Impact on knowledge. Integrating methods, skills and strengths of different disciplines, this interdisciplinary project will yield new knowledge of value to researchers and manufacturers involved in nanoscience and biomedicine. This work will assist them - both in industry and academia - to better understand, predict and control nanoparticle synthesis processes and to produce advanced functionalized nanomaterials reproducibly. Our industrial partners will directly benefit by actively engaging in the development of this technology, acquiring knowledge on fundamental aspects of continuous-flow nanoparticle synthesis and engineering, and being able to evaluate early this technology. By widely disseminating this work, we will help the broader community of scientists, engineers and manufacturers working in this area to understand this technology and realize its potential.

Impact on people. The researchers involved in this project will be highly trained in a wide range of areas, including nanotechnology, materials chemistry, flow chemistry, chemical engineering and microfluidics. They will bolster their ability to work in a highly interdisciplinary environment independently and in a team, acquiring technical and transferable skills that will enhance their professional development and employability.

Publications

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Damilos S (2019) Experimental and computational investigation of heat transfer in a microwave-assisted flow system in Chemical Engineering and Processing - Process Intensification

 
Description Three different categories of nanoparticles are targeted: 2nm gold nanoparticles that find application in antimicrobial materials and coatings, 20-40 nm gold nanoparticles for diagnostics and iron oxide nanoparticles that are attractive for cancer hyperthermia.
Regarding the 2 nm gold nanoparticles, the high-throughput synthesis of Au25 clusters (sub-2 nm, ~1 gAu/day) has been developed with a continuous flow system. We have made a discovery for making a surface that is the world's most potent light activated antimicrobial coating. The work was published in Nature Communications (DOI 10.1038/s41467-020-15004-6) and has had a lot of media interest. We showed that our coatings rapidly kill gram positive and gram negative bacteria on a surface by the action of room lighting. We showed that the coating worked mainly by the formation of hydrogen peroxide.
In terms of the continuous flow synthesis of 20-40 nm gold nanoparticles, a two-phase flow reactor system has been developed for the continuous manufacturing of targeted gold nanoparticles, and the coupled online UV-Vis spectrometer in the system allowed online quality monitoring of the Au nanoparticles.
Continuous flow reactors in combination with X-ray scattering techniques facilitated novel insights into the particle formation mechanism of iron oxide nanoparticles synthesized via the aqueous co-precipitation method. The knowledge gained was essential for the design of continuous reactors for manufacturing, and made it possible to synthesize ~5 nm particles (which is considered as a promising size for MRI T1 contrast agents) using cost effective methods.
Exploitation Route Translating these batch processes into continuous flow manufacturing processes can benefit companies to continuously synthesize functional nanoparticles with control over their size and their properties. Additionally, the antimicrobial manufacturing methodologies developed are of great interest to relevant industries dealing with antimicrobial coatings and membranes for hospital and healthcare use.
The methods developed to study particle formation kinetics facilitated via flow reactor designs answered many questions on the growth mechanism of co-precipitation of iron oxide nanoparticles guiding future synthesis and allowing for further optimization based on the better understood particle formation kinetics.
Sectors Chemicals,Healthcare,Manufacturing, including Industrial Biotechology

URL https://www.ucl.ac.uk/chemical-engineering/research/manufacturing-advanced-functional-materials-mafuma
 
Description This project has been in close engagement with University College London Hospitals (UCLH). The outcome of our research has a potential application in hospital and healthcare use, especially for antimicrobial surfaces. The continuous gold nanoparticles synthesis we have developed in this project, which can help reduce risk and capital cost associated with scaling up and facilitate routes to market, can be employed by the UK nanotechnology industry. Other applications such as antimicrobial endotracheal tubes are being considered. Academic collaborations have been established for the study of the catalytic activities and the relaxivity for MRI contrast agent candidates or iron oxide nanoparticles manufactured using continuous methods.
First Year Of Impact 2020
Sector Healthcare
Impact Types Societal,Economic

 
Description Centre for Nature Inspired Engineering, inspiration grant: Nature Inspired Green, Tuneable & Scalable Synthesis of Magnetic Nanoparticles
Amount £26,120 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 11/2019
 
Description EPSRC Impact Acceleration Account Discovery-to-Use award: Pilot Platform Development for the Continuous Manufacturing of Gold Nanoparticles for Diagnostic Applications
Amount £48,449 (GBP)
Funding ID EP/R511638/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 03/2020
 
Description Design of a micropump system for next generation healthcare 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration was with the University of Strathclyde, under the framework of a "StrathWide2019 Grant Proposal Application", i.e., an internal (to the University of Strathclyde) grant that was awarded (~300 pound budget). Our contribution was the advice on flow sensors and material selection for the targeted chip design. Dr. Maximilian Besenhard supports this project as PI.
Collaborator Contribution The contribution of the collaborators included the advice on low cost pump solutions that work reliable at flow rates below 1 ml/min (including experimental studies to prove that).
Impact Knowledge of low cost pump solutions that can be used for commercialization of reactors developed in the MAFuMa project Knowledge of low cost pump solutions that can be used for scale-up via parallelization of reactors developed in the MAFuMa project
Start Year 2019
 
Description Synchrotron studies for in-line characterisation of nanomaterials 
Organisation Central European Research Infrastructure Consortium
Country Italy 
Sector Public 
PI Contribution Combination of in-situ synchrotron radiation with flow reactors. Flow reactors as developed within the MAFuMa project were combined with a self-made flow cell (made at UCL) through which the synchrotron radiation was guided. These set-ups, combining flow cell measurements with steady state operations of flow reactors, allowed for investigations of transient reaction states during the formation of iron oxide nanoparticles. Tasks performed by the PI and other members of the MAFuMa research team: -Construction of flow cell -Construction of flow reactor -Development of synthesis protocol -Evaluation of data (after initial data processing) CERIC ERIC internal research project: Nano Analytics in Pharmaceutics
Collaborator Contribution Tasks performed by partners: -Setting up beamline -Installation of flow cell -Initial data processing
Impact - multiple scientific articles (currently in progress) - patent application by project partner (currently in progress) - proof of concept studies for further common funding applications (including applications for beam line time)
Start Year 2018
 
Title Development of pilot platform for continuous manufacturing of gold nanoparticles for diagnostic applications 
Description A novel manufacturing platform to establish a high quality (specific particle size with low polydispersity) gold nanoparticle synthesis in flow. The synthesised gold nanoparticles can be used in biomedical and diagnostic applications. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2019 
Impact This technology has the potential to improve the current manufacturing routes in industry by replacing batch-reactor centred techniques to more cost and environmental beneficial flow processes. The designed platform - integrated with monitoring and control - acts as a launching pad for a comprehensive dial-a-nanoparticle system aligned with the directions of the "Industry 4.0" philosophy. 
 
Description Fourth Hellenic Forum for Science and Technology and Innovation, Athens, Greece 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Fourth Hellenic Forum for Science and Technology and Innovation, Athens, Greece. Invited by Prof Gorge Loudos. Jul. 2016
Year(s) Of Engagement Activity 2016
 
Description ACS Applied Materials & Interfaces, to be held at the Spring ACS National Meeting (March 31 - April 4, 2019) in Orlando, Florida 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". March 31 - April 4, 2019. Orlando, Florida
Year(s) Of Engagement Activity 2019
 
Description EU COST TD142 - Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (Radiomag), Bilbao, Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Bilbao, Spain, Apr. 2017
Year(s) Of Engagement Activity 2017
 
Description EU COST TD142 Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (Radiomag), Annual Action Progress Conference, Florence, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Florence, Italy. Oct. 2018
Year(s) Of Engagement Activity 2018
 
Description European Nanomedicine Meeting, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". European Nanomedicine Meeting, London, UK. Invited by Prof Steve Rannard. April 2017
Year(s) Of Engagement Activity 2017
 
Description ICMAT symposium AA of advanced ceramics and nanohybrids for energy, environment and health. Singapore. Invited by Prof Federico Rosei. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications", ICMAT, Singapore.July 2015
Year(s) Of Engagement Activity 2015
 
Description Mentor for Vietnam-UK Workshop on Microfluidics, Nanomaterials, and Point-of-Care in Healthcare for developing countries, Ho Chi Minh City, Vietnam. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Ho Chi Minh City, Vietnam. Jun. 2018
Year(s) Of Engagement Activity 2018
 
Description Micro /Nanotechnologies for Diagnostics and Therapeutics workshop organised by Royal Society Chemistry Biotechnology Group. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Apr. 2019
Year(s) Of Engagement Activity 2019
 
Description Plenary lecture in "Nanoparticle synthesis, structure, properties, safer-by-design" Section of 7th biannual International Meeting of The Institute of Metals in Biology of Grenoble (IMBG) "Metallic nanoparticles: health, environment, applications and safer-by-design", Grenoble, France. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Grenoble, France. Oct. 2017
Year(s) Of Engagement Activity 2017
 
Description Plenary talk at the 7th International Conference in Vietnam on the Development of Biomedical Engineering, Ho Chi Minh City, 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Ho Chi Minh City, Vietnam. Jun. 2018
Year(s) Of Engagement Activity 2018
 
Description Symposium N "Advanced Ceramics and Nanohybrids for Energy, Environment and Health symposium", ICMAT 2017, Singapore. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". ICMAT 2017, Singapore.
Year(s) Of Engagement Activity 2017
 
Description Symposium V "Nanomaterials": Design and hierarchical assemblies of nanomaterials (nanoparticles, carbon materials, molecules) towards energy, sensing, electronic, catalysis and detection applications, Strasbourg, France. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Strasbourg, France. May 2017
Year(s) Of Engagement Activity 2017
 
Description Worldwide Meeting of Young Academy and Nanomaterial for Health jointly organized with Global Young Academy and Vietnam Young Academy, Da nang, Vietnam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Da nang, Vietnam. Jul. 2019
Year(s) Of Engagement Activity 2019
 
Description 10th International Conference on Materials for Advanced Technologies (ICMAT 2019) Symposium Y: "Colloidal Nanoparticle-Based Probes and Sensors" (Jointly organized with MRS Japan), Singapore. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". ICMAT 2019. Singapore. Jun. 2019
Year(s) Of Engagement Activity 2019
 
Description 10th International Conference on Materials for Advanced Technologies (ICMAT 2019) Symposium J "Micro/nano-technology for Drug Delivery and Imaging", Singapore. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications".ICMAT 2019. Singapore. Jun. 2019
Year(s) Of Engagement Activity 2019
 
Description 29th European Conference on Biomaterials: "Continuous Flow Synthesis of Gold Nanoparticles for Biomedical Applications" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact C. Körner, H. Huang, M. O. Besenhard, A. Gavriilidis, T. Luxbacher, "Continuous Flow Synthesis of Gold Nanoparticles for Biomedical Applications", 29th European Conference on Biomaterials, ESB2018, Maastricht, 9-13 September 2018, Poster presentation.
Year(s) Of Engagement Activity 2018
 
Description 5th International Workshop on Novel Magnetism and Multifunctional Materials, Hanoi, Vietnam. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications".Hanoi, Vietnam. Jan. 2019
Year(s) Of Engagement Activity 2019
 
Description 8th CBM Workshop "Sub- 5 nm Gold Nanoparticle Synthesis by the Turkevich Method in a Microfluidic System" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presentation given at 8th Workshop "Chemical and Biological Micro Laboratory Technology", Ilmenau/Elgersburg, Germany, 23-25 February 2016. Presentation title: H. Huang, R. Baber, H. Du Toit, I. Parkin, A. Gavriilidis, "Sub- 5 nm Gold Nanoparticle Synthesis by the Turkevich Method in a Microfluidic System"
Year(s) Of Engagement Activity 2016
URL https://www.tu-ilmenau.de/mrt/cbm-workshops/8-cbm-workshop-2016/
 
Description AIChE 2016: "Study on Gold Nanoparticles Flow Synthesis in a Microwave-Assisted Reactor" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral Presentation
M. K. Bayazit, S. P. Damilos, E. Cao, A. Gavriilidis, J. Tang, "Study on Gold Nanoparticles Flow Synthesis in a Microwave-Assisted Reactor", AIChE Annual Meeting, San Francisco, November 2016.
Year(s) Of Engagement Activity 2016
URL https://www.aiche.org/conferences/aiche-annual-meeting/2016
 
Description COST - RADIOMAG2017 Poster presentation - Continuous Syntheses of Iron Oxide Nanoparticles for Large Scale Production 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster Presentation:
Maximillian O. Besenhard, Alec P. LaGrow, Katerina Loizou, Nguyen T. K. Thanh, and Asterios Gavriilidis
Year(s) Of Engagement Activity 2018
 
Description Contribution to Elettra Sincrotrone Trieste highlights 2018-2019 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The annual highlight journal published by the Elettra Synchrotron facilities featured the article "New light on growth mechanisms of iron oxide nanoparticles (IONPs)" written by MAFuMa members. Publishing in this in-house journal provides an advantage for future beam time applications.
Year(s) Of Engagement Activity 2019
URL https://www.elettra.trieste.it/images/Documents/SCIENCE/Elettra%20HL%202019.pdf
 
Description Dept of Chemical and Biological Engineering, HKUST: "Nanoparticle Synthesis in Flow", 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Seminar: A. Gavriilidis, "Nanoparticle Synthesis in Flow", Dept of Chemical and Biological Engineering, HKUST, Hong Kong, 5 December 2018.
Year(s) Of Engagement Activity 2018
 
Description EU COST TD142 Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (Radiomag), Annual Action Progress Conference, Timisoara, Romania 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Timisoara, Romania. Mar. 2018
Year(s) Of Engagement Activity 2018
 
Description Functional Nanomaterials in Industrial Applications: Academic-Industry Meet, Preston, UK. Keynote speaker. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Functional Nanomaterials in Industrial Applications: Academic-Industry Meet, Preston, UK. Keynote speaker, Invited by Dr Tapas Sen. Mar. 2016
Year(s) Of Engagement Activity 2016
 
Description IChemE Particle Technology Special Interest Group meeting January 2017: "Nanoparticle and Microparticle Production in Flow" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Oral presentation A. Gavriilidis, L. Mazzei, "Nanoparticle and Microparticle Production in Flow", IChemE Particle Technology Special Interest Group meeting, London, 23 January 2017.
Year(s) Of Engagement Activity 2017
URL http://www.icheme.org/communities/special-interest-groups/particle%20technology/events/2017/agm-23ja...
 
Description IMRET 14, "Continuous Synthesis of Gold Nanoparticles with Carbon Monoxide in Segmented Flow System" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation
H. Huang, H. du Toit, R. Baber, I. Parkin, A. Gavriilidis, "Continuous Synthesis of Gold Nanoparticles with Carbon Monoxide in Segmented Flow System", 14th International Conference on Microreaction Technology, Beijing, China, 11-14 September 2016.
Year(s) Of Engagement Activity 2016
 
Description IMRET 14, "Controlling Nucleation using UV Light for the Synthesis of Citrate Capped Gold Nanoparticles" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation
H. du Toit, T. Macdonald, H. Huang, L. Mazzei, I. Parkin, A. Gavriilidis, "Controlling Nucleation using UV Light for the Synthesis of Citrate Capped Gold Nanoparticles", 14th International Conference on Microreaction Technology, Beijing, China, 11-14 September 2016.
Year(s) Of Engagement Activity 2016
 
Description IMRET 14, "From Batch to Flow: Developing our Understanding of Multiphase Reaction Systems for the Synthesis of Thiol Stabilised Gold Nanoparticles in Continuous Flow" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation
H. du Toit, T. Macdonald, I. Alissandratos, C. Makatsoris, I. Parkin, A, Gavriilidis, "From Batch to Flow: Developing our Understanding of Multiphase Reaction Systems for the Synthesis of Thiol Stabilised Gold Nanoparticles in Continuous Flow" , 14th International Conference on Microreaction Technology, Beijing, China, 11-14 September 2016.
Year(s) Of Engagement Activity 2016
 
Description Keynote Lecture at the 6th Annual Postgraduate symposium on Nanoscience and Nanotechnology, School of Chemistry at the University of Birmingham, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". 6th Annual Postgraduate symposium on Nanoscience and Nanotechnology, School of Chemistry at the University of Birmingham, UK. Invited by Dr Dwaipayan Chakrabarti. Dec. 2016
Year(s) Of Engagement Activity 2016
 
Description Keynote, 2019 Hanoi International Symposium on Advanced Materials and Devices (HISAMD2019) Hanoi, Vietnam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications".HISAMD2019. Hanoi, Vietnam. Jan.2019
Year(s) Of Engagement Activity 2019
 
Description MRS Spring Meeting 2016, "Size Controlled Synthesis of Gold Nanoparticles Using Light Induced Reduction" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation
H. du Toit, T. Macdonald, I. Parkin, A. Gavriilidis, "Size Controlled Synthesis of Gold Nanoparticles Using Light Induced Reduction " 2016 MRS Spring Meeting, Phoenix, Arizona, March 2016.
Year(s) Of Engagement Activity 2016
URL http://www.mrs.org/spring2016
 
Description Nano-biotechnology on Interfaces Symposium at IUMRS-ICAM 2017, the 15th International Conference on Advanced Materials. Kyoto. Japan. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Kyoto. Japan, Sep. 2017
Year(s) Of Engagement Activity 2017
 
Description Oral presentation at "Nanoparticles for Cancer Diagnosis and Therapy" conference sponsored byBritish Society of Surgical Oncology and Royal Society of Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications".invited by Professor Riccardo Audisio. Nov. 2015
Year(s) Of Engagement Activity 2015
 
Description Oral presentation at CSIR, National Chemical Laboratory and IIT in India (2020) on "Metal manoparticle synthesis in millifluidic systems" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof Asterios Gavriilidis.
Gavriilidis, A. "Metal manoparticle synthesis in millifluidic systems", CSIR, National Chemical Laboratory, Pune and IIT, Mumbai, India, January 2020.
Year(s) Of Engagement Activity 2020
 
Description Oral presentation at FLOWMAT 2019 in Paris 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral presentation at FLOWMAT 2019 conference in Paris to 50-100 attendees, all very active and reputable in the flied of flow chemistry.
Year(s) Of Engagement Activity 2019
URL https://msmsm.sciencesconf.org/data/pages/Programme_FLOWMAT2019_V2.pdf
 
Description Oral presentation at IVAM System Integration (2019) on "Developing manufacturing technologies for synthesis of nanomaterials for healthcare applications" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof Asterios Gavriilidis.
Gavriilidis, A. "Developing manufacturing technologies for synthesis of nanomaterials for healthcare applications", Microfluidics in Industry and Life, IVAM System Integration, Manchester, UK, 9 October 2019.
Year(s) Of Engagement Activity 2019
 
Description Oral presentation at St John's College, Cambridge (2019) on "Development of a nanoparticle synthesis millifluidic systems - A reaction engineering approach" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof Asterios Gavriilidis.
Gavriilidis, A. "Development of a nanoparticle synthesis millifluidic systems - A reaction engineering approach", Manufacturing of materials in flow, St John's College, Cambridge, UK, 22 - 24 September 2019.
Year(s) Of Engagement Activity 2019
 
Description Oral presentation at the 13th Biennial International Conference on EcoBalance 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral presentation by Martina Pucciarelli: Results of an ongoing study on the comparison between the batch and in continuous flow synthesis of gold nanoparticles from both an environmental and economic point of view were presented. After the presentation, an interesting discussion about the scaling up and the further steps of the project took place, showing increasing interest on the methodology used to overcome the problems of scaling up/out innovative processes.
Year(s) Of Engagement Activity 2018
URL http://www.ecobalance2018.org/program/EcoBalance2018_Program.pdf
 
Description Oral presentation at the 1st International Workshop on Flow Synthesis of Multi-Scale Materials (2019) on "Flow synthesis of 50 nm gold nanoparticles via a seeded-growth approach - From kinetics measurements to reactor design" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Luca Panariello.
Panariello, L., To, K., Wu, G., Damilos, S., Parkin, I. P., Gavriilidis, A. "Flow synthesis of 50 nm gold nanoparticles via a seeded-growth approach - From kinetics measurements to reactor design", 1st International Workshop on Flow Synthesis of Multi-Scale Materials, FLOWMAT 2019, Paris, France, 26-28 June 2019.
Year(s) Of Engagement Activity 2019
 
Description Oral presentation at the 2nd International Process Intensification Conference (2019) on "Continuous synthesis of ferromagnetic iron oxide nanoparticles for magnetic hyperthermia using a droplet reactor with controlled reducing environment" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Luca Panariello.
Panariello, L., Wu, G., Besenhard, M., Gavriilidis, A. "Continuous synthesis of ferromagnetic iron oxide nanoparticles for magnetic hyperthermia using a droplet reactor with controlled reducing environment", 2nd International Process Intensification Conference, IPIC2, Leuven, Belgium, 27-29 May 2019.
Year(s) Of Engagement Activity 2019
 
Description Oral presentation at the 2nd International Process Intensification Conference (2019) on "From batch to continuous flow: A life cycle assessment of gold nanoparticles production" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An oral presentation by Fabio Grimaldi.
Grimaldi, F., Pucciarelli, M., Gavriilidis, A., Lettieri, P. "From batch to continuous flow: A life cycle assessment of gold nanoparticles production", 2nd International Process Intensification Conference, IPIC2, Leuven, Belgium, 27-29 May 201
Year(s) Of Engagement Activity 2019
 
Description Oral presentation at the NATO ASO series (2019) on "Iron oxide nanoparticles: Systematic improvement of particle properties and reduction of synthesis time" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An oral presentation by Dr Liudmyla Storozhuk.
Storozhuk, L., Besenhard, M.O., LaGrow, A.P., Gavriilidis, A. and Thanh, N.T.K. "Iron oxide nanoparticles: Systematic improvement of particle properties and reduction of synthesis time", NATO, ASI, Nanoscience and Nanotechnology in Security and Protection Against CBRN Threats, Sozopol, Bulgaria, 12-20 September 2019.
Year(s) Of Engagement Activity 2019
 
Description Participation to "in2science" charity organisation: hosting several summer students from disadvantaged backgrounds 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Hosting of two students in the summer from disadvantaged backgrounds supporting them to achieve their potential and progress to STEM and research careers through a high quality work placement and careers guidance.
Year(s) Of Engagement Activity 2019
URL https://in2scienceuk.org/
 
Description The 3rd Overseas Academicians Qingdao Tour & Qingdao International Academicians Conference, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". China. May 2019
Year(s) Of Engagement Activity 2019
 
Description UK Colloids 2017: "Continuous Flow Synthesis of Iron Oxide Nanoparticles" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral Presentation: A. LaGrow, M. Besenhard, A. Gavriilidis, N. Thanh, "Continuous Flow Synthesis of Iron Oxide Nanoparticles", UK Colloids 2017, Manchester, 10-12 July 2017.
Year(s) Of Engagement Activity 2017
 
Description UK Magnetics Society seminar on MRI and Magnetic Particles for MRI Diagnostics, University of Oxford, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". Oxford, UK. Feb. 2019
Year(s) Of Engagement Activity 2019
 
Description UK-India Education and Research Initiative (UKIERI) Workshop on Magnetic nanoparticles characterisation and applications, University of Centre Lancashire, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Prof. Nguyen T.K. Thanh "Plasmonic and magnetic nanoparticles for biomedical applications". University of Centre Lancashire, UK. Invited by Dr Tapas Sen. Aug. 2015
Year(s) Of Engagement Activity 2015
 
Description WWCE10: "Optimizing Nanoparticle Synthesis via Flow Chemistry" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral Presentation: M. Besenhard, A. LaGrow, N. Thanh, A. Gavriilidis, "Optimizing Nanoparticle Synthesis via Flow Chemistry", 10th World Congress in Chemical Engineering, Barcelona, Spain, 1-5 October, 2017.
Year(s) Of Engagement Activity 2017
 
Description e-MRS Spring Meeting 2016, "Sub- 5 nm Gold Nanoparticle Synthesis by the Turkevich Method in a Microfluidic System" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation
H. Huang, R. Baber, H. Du Toit, I. Parkin, A. Gavriilidis, "Sub- 5 nm Gold Nanoparticle Synthesis by the Turkevich Method in a Microfluidic System", e-MRS, European Materials Research Society Spring Meeting 2016, Lille, France 2-6 May 2016.
Year(s) Of Engagement Activity 2016
URL http://www.european-mrs.com/meetings/2016-spring-meeting