Next Generation Biomaterials Discovery

Lead Research Organisation: University of Nottingham
Department Name: Sch of Pharmacy

Abstract

Advanced biomaterials are essential components in targeting infectious diseases and cancers, realising the potential of regenerative medicine and the medical devices of the future. A multidisciplinary team spanning Engineering, Science and Medical Faculties in Nottingham, in collaboration with 4 leading international groups has combined to realise the vision of materials discovery in 3D. Without this leap beyond 2D screening methodologies we will miss new advanced materials because they omit architecture and often poorly represent the in vivo environment. The aim is to allow us to move beyond the existing limited range of generic bioresorbable polymeric drug and cell delivery agents currently licensed for use in man and medical device polymers, to bespoke materials identified to function optimally for specific applications.

We know that defining chemistry, stiffness, topography and shape can control the response of cells to materials. This programme will focus on producing and testing large libraries of these attributes in the form of patterned surfaces, particles and more complex architectures. New materials will be identified for application in the areas of targeted drug delivery, regenerative medicine and advanced materials for next generation medical devices.

The 3D screening methods will define a new landscape in biomaterials discovery and create the platforms through which more effective advanced materials will be discovered. Our three ambitious application focussed areas provide high impact examples in which our biomaterials leads are developed towards exploitation in the clinic. These downstream projects will be carried out in both academic and commercial research programmes funded through partnering, licensing and formation of spin-outs as appropriate.

Planned Impact

Beneficiaries from the proposed research will include:

- In the short-term, researchers in the Programme Grant's challenge areas will benefit from the provision of new materials with which to develop biomaterial solutions to healthcare needs. When these materials make their way to the clinic, patients will benefit from improved biomaterials that will result in reduced morbidity and mortality. Clinicians will benefit through the provision of increased treatment options.
- Society will benefit from reduced healthcare costs associated with hospital associated infections, reduced medical implant rejection and improved quality of life for the ageing population.
- Commercial partners in regenerative medicine, the pharmaceutical industry and medical devices will benefit from the generation of new revenue streams associated with new materials which will positively influence the economic competitiveness of the United Kingdom.
- The methodologies developed will have significant impact in the materials scientific research community, facilitating the vision of targeted materials function. These will be applicable beyond healthcare to various sectors including energy, food and manufacturing.
- The researchers involved in the programme and investigators will benefit from highly interdisciplinary training in the growth area of materials and exposure to different ways of working within the UK and international partners.

From a commercial perspective, research is targeted to be directly relevant to 3 broad groups of beneficiaries with whom we have close working relationships established through current research projects:

- In Regenerative Medicine we are collaborating with GE Healthcare, Intercytex, Mica Technologies, Haemostatix, Neusentis, Locate Therapeutics, Neotherix, NCTS, Tokyo Electron and Syngenta.
- In Pharmaceutics, we are collaborating with GlaxoSmithKline, AstraZeneca, Pfizer, Greenpharma, UCB Pharma, PsiOxus, Novozymes, Boots and Molecular Profiles.
- In Medical Devices we are collaborating with Smith and Nephew, Dow Corning, Arterius, Camstent, Protip Medical, Tensive Medical and J&J Visioncare.


Examples of expected outputs include:-

- The discovery of lead material-topography combinations for stem cell differentiation into bone.
- Polymers with the potential to efficiently traffic therapeutics through the body to deliver them preferentially in the vicinity of infections and tumours.
- Mature cardiomyocytes for drug toxicity screening in the pharmaceutical industry.
- Materials which have an immune instructive effect to reduce failure for dental and orthopaedic implants.
- ChemoTopo Chips that will be of use in screening for cell instructive materials in the regenerative medicine industry.
- New 3D models of polymicrobial infections to identify future strategies for preventing/treating chronic infections. This will enable transformational approaches to be taken to meet unmet clinical needs.

Publications

10 25 50

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Alvarez MM (2016) Delivery strategies to control inflammatory response: Modulating M1-M2 polarization in tissue engineering applications. in Journal of controlled release : official journal of the Controlled Release Society

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Amin YY (2016) Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior. in Advanced materials (Deerfield Beach, Fla.)

 
Title Scales of Resistance video 
Description A short video presentation providing educational information regarding the issue of antibiotic resistance and the need to take effective action in the future. 
Type Of Art Film/Video/Animation 
Year Produced 2019 
Impact Used as part of the Royal Society Summer Science Online programme promoting science to the general public. 
URL https://cfvod.kaltura.com/p/1355621/sp/135562100/thumbnail/entry_id/1_y72nz7d1/version/100001/width/...
 
Title Super biomaterials to fight superbugs 
Description A short animated video showing how Nottingham University are trying to find novel surface coatings that prevent superbugs sticking and building slime city communities called biofilms. 
Type Of Art Film/Video/Animation 
Year Produced 2019 
Impact Used as part of the Royal Society Summer Science Online programme promoting science to the general public. 
URL https://cfvod.kaltura.com/p/1355621/sp/135562100/thumbnail/entry_id/1_00ytd3sg/version/100001/width/...
 
Description The six following publications represent key findings from the grant:

1. Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
Vassey et al. Advance Science, 2020.
https://doi.org/10.1002/advs.201903392

In this publication, members of Next Generation Biomaterial Discovery team (including Maastricht University collaborator) identified specific surface structures which promoted or inhibited macrophage immune cells from attaching to surfaces and illustrate that biomaterials can be designed to modulate inflammatory responses in the fight against foreign body rejection of medical devices.

Using a high throughput screening approach, the authors were able to look at over 2000 micropatterns to show immune cells can be modulated by specific topographies to promote pro-healing phenotypes which could potentially have beneficial effects on long term biomaterial integration.

2. Topographical biomaterials instruct bacterial surface attachment and the in vivo host-pathogen response
Manuel Romero et al.
https://doi.org/10.1101/2020.10.10.328146

This study tackled the prevention of biofilm development on the surfaces of implanted medical devices, a global challenge in the healthcare sector by applying materials discovery.

Bio-instructive materials that intrinsically prevent bacterial biofilm formation and drive an appropriate host immune response are required to reduce the burden of healthcare associated infections. Although bacterial surface attachment is known to be sensitive to shapes at the micrometre and nanometre scales, its exploitation has been limited by the lack of unbiased high throughput biomaterial screening combined with model-based methods capable of identifying correlations and predicting generic responses across a large library of features.

This study filled this knowledge gap by using polymer chips, incorporating 2176 different surface structures, to assess bacterial pathogen attachment. A strong correlation between some surface shapes, bacterial attachment and biofilm formation was established, facilitated by using machine learning methods to analyse specific surface parameters for predicting attachment. Further experiments showed that candidate surface structures were able to prevent colonization against selected bacterial pathogens in vitro.

3. Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models
Pearce et al.
Advanced Heathcare Materials 2020
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202000892

This study reported the synthesis and application against Triple Negative Breast Cancer (TNBC) of a library of new architecturally-defined polymers with systematic variations in size, shape, placement of degradable groups and pro-drug linkers. eThe polymers were designed to probe key transport pathways in complex 3D in vitro cancer models, and also in orthotopic TNBC in mice.The study showed for the first time that changes in size of less than 5 nm and variations in shape from 'star' to 'hyperbranched' architectures markedly altered organ accumulation in miceThis information was used to design an in vivo efficacy study, which demonstrated better tumour reduction of a specific polymer-doxorubicin carrier compared to the free drug, and with better tolerability. These data are informing our design of next generation combination polymer therapeutics.

4. Synergistic Material-Topography Combinations to Achieve Immunomodulatory Osteogenic Biomaterials
Burroughs et al, 2021
https://doi.org/10.1101/2020.04.29.067421 accepted for publication in Biomaterials 25/2/2021

This study reported on a novel screening platform developed in this project, called a ChemoTopoChip used to identify new cell-instructive materials, exemplified here for use in bone regeneration.

Using a large library of materials with different topography shapes, and with the help of machine learning, the study was able to reveal the relative roles of topography and material chemistry on the immunomodulatory and bond forming propensity of macrophage and stem cells respectively, both of which play key roles in the regeneration process. Ultimately this allows identification of biomaterials able to modulate cells towards pro-healing phenotypes and offering a materials-induced alternative in bone-regenerative applications.

5. Discovery of a Novel Polymer for Xeno-Free, Long-Term Culture of Human Pluripotent Stem Cell Expansion
Nasir et al., Advanced Healthcare Materials 2020
https://doi.org/10.1002/adhm.2020014482020

Human pluripotent stem cells (hPSC) can be expanded and differentiated into almost any adult tissue cell type, thus making them a valuable source for various biomedical applications. In this study, a high-throughput materials discovery approach was used to screen over 600 hPSC-polymer interactions to identify a novel fully-defined material (polymer synthetic substrate) for hPSC culture. This system overcomes current limitations of hPSC culture methods, providing a scalable substrate which can be readily applied to tissue culture plasticware; whilst retaining stem cell integrity after long-term serial culture. Fulfilment of regulatory culture requirements makes this research translatable to clinical-scale and biomedical applications.

6. Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering
Amer et al. Biomaterials, 2021
https://doi.org/10.1016/j.biomaterials.2020.120450

Mesenchymal stem cells, a type of cell that can make several types of cells belonging to our skeletal tissues, such as cartilage and bone, are a focus of intense research in bone development and regeneration. This study investigated how microparticles of varying sizes with different topologies (shapes) influenced mesenchymal stem cell attachment, proliferation (cell growth) and markers of osteogenesis (bone growth). The study highlighted the ability to modify and manipulate the cell responses to achieve desired cell fates without the need for other external factors.
Exploitation Route In the original pathways to impact document the following beneficiaries were cited-we note progress under these headings and anticipated future opportunities:

1. Researchers, from the provision of new materials with which to develop biomaterial solutions to healthcare needs.

Vassey et al Advance Science (https://doi.org/10.1002/advs.201903392) has received 11 citations already and been highlighted in significant reviews such as "Combating Implant Infections: Shifting Focus from Bacteria to Host" Advanced Materials 2020.

2. Patients, when these materials make their way to the clinic

Materials directly from the programme grant have not yet made it to the clinic, but proof of concept work is underway with commercial partners in the area of wound care, venous catheters and more widely across their portfolio.

3. Clinicians, through the provision of increased treatment options

A polymer identified by materials discovery which preceded this grant is now on the NHS catalogue as a urinary catheter with reduced bacterial colonisation. First in man data is encouraging and a large-scale clinical trial to quantify efficacy across a homogeneous patient cohort is scheduled for 2021.

4. Society, from reduced healthcare costs

See 3

5. Commercial partners, generation of new revenue streams associated with new materials

Ongoing collaborations with companies make this an achievable goal for the future. We have used iCURE and Wellcome Trust business development funding to establish a link to companies with potential application areas.

6. The research community facilitating the vision of bespoke materials.

See 1

7. Beyond healthcare to various sectors including energy, food and manufacturing.

Collaboration with commercial partners are underway in reducing bacterial colonisation of water handling systems

Benefits through research training will grow the PDRAs involved in the programme and the investigators will benefit from highly interdisciplinary training in the area of biomaterials discovery and exposure to different working approaches with international partners, e.g. time spent in the leading translational Langer Lab culture that has produced many research stars.

Benefits to the public through our engagement programmes. We took an active role in The Royal Society Summer Exhibition 2019 and 2020 (as well as numerous local Nottingham Public Engagement events). https://royalsociety.org/science-events-and-lectures/2020/summer-science-online/
Sectors Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL https://doi.org/10.1002/advs.201903392,https://doi.org/10.1101/2020.10.10.328146,https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202000892,https://doi.org/10.1101/2020.04.29.067421,https://doi.org/10.1002/adhm.2020014482020,https://doi.org/10.1016/j.biomaterials.2020.120450
 
Description Commercialisation of a bacteria resistant coated urinary catheter product, 'a bench to bedside' success. Discovery of a new class of bacteria resistant materials by the grant has enabled the successful development of a bacteria resistant coated catheter. Camstent Ltd, who have licensed the patented technology, have attracted GBP4,500,000 of investment, opened an ISO approved manufacturing facility with commercially attractive production capacity, and obtained a CE mark for a urinary catheter with a 'bacteriaphobic' descriptor.
First Year Of Impact 2018
Sector Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Economic

 
Description Acellular / Smart Materials - 3D Architecture: UK RMP Hub
Amount £4,092,161 (GBP)
Funding ID MR/R015651/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 04/2023
 
Description Acellular Approaches for Therapeutic Delivery: UK Regenerative Medicine Platform Hub Application
Amount £3,944,501 (GBP)
Funding ID MR/K026682/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2013 
End 03/2018
 
Description BBSRC National Biofilms Innovation Centre Innovative Knowledge Centre
Amount £15,600,000 (GBP)
Funding ID BB/R012415/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2022
 
Description Bacterial Decision Making; to stick or not to stick?
Amount £50,000 (GBP)
Funding ID 103882/Z/14/B 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2019 
End 10/2020
 
Description Bacterial Surface Sensing to Stick or not to Stick?.
Amount £933,419 (GBP)
Funding ID 103884 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 10/2020
 
Description EMPIR: 'MetVBadBugs'
Amount € 389,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 06/2016 
End 05/2019
 
Description EPSRC 3D OrbiSIMS: Label free chemical imaging of materials, cells and tissues.
Amount £2,500,000 (GBP)
Funding ID EP/P029868/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2017 
End 07/2022
 
Description EPSRC Thematic Doctoral Training Programme: Bioinstructive materials for healthcare applications (BMHA)
Amount £280,241 (GBP)
Funding ID EP/N50970X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 03/2020
 
Description EPSRC Thematic Studentship
Amount £280,241 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2017 
End 08/2020
 
Description EPSRC: Engineering Growth Factor Microenvironments
Amount £3,700,000 (GBP)
Funding ID EP/P001114/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2021
 
Description EPSRC: Formulation for 3D printing
Amount £3,800,000 (GBP)
Funding ID EP/N024818/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description EPSRC: Healthcare Technologies Impact Fellowship
Amount £540,000 (GBP)
Funding ID EP/N03371X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 12/2016 
End 11/2018
 
Description Enabling Next Generation Additive Manufacturing for Pharma and related industries
Amount £5,900,000 (GBP)
Funding ID EP/P031684/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2017 
End 08/2022
 
Description Expanding the Horizons of Imaging: Real-time Tracking of Drugs in the Brain
Amount £202,381 (GBP)
Funding ID EP/V049291/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2021 
End 12/2022
 
Description Experiencing the micro-world - a cell's perspective
Amount £600,755 (GBP)
Funding ID EP/R035563/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2018 
End 11/2021
 
Description FindABetterWay: Working together
Amount £2,800,000 (GBP)
Organisation Find a Better Way 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2022
 
Description Fully humanised 3D vascular perfused model for breast cancer modelling and therapeutic screening
Amount £75,911 (GBP)
Funding ID NC/T001259/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 09/2021
 
Description H2020 grant 'Personalised Integrated Biomaterials Risk Assessment (PanBioRA)'
Amount € 7,944,786 (EUR)
Funding ID 760921 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2018 
End 12/2021
 
Description High resolution, cryogenic analytical and transfer scanning electron microscope (HR-CAT-SEM)
Amount £1,564,542 (GBP)
Funding ID EP/S021434/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2024
 
Description High resolution, cryogenic analytical and transfer scanning electron microscope (HR-CAT-SEM)
Amount £1,564,542 (GBP)
Funding ID EP/S021434/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2024
 
Description How simple plastic surfaces can be recruited to the fight against contact transmission of SARS-CoV-2
Amount £417,480 (GBP)
Funding ID EP/V055372/1 
Organisation United Kingdom Research and Innovation 
Sector Public
Country United Kingdom
Start 01/2021 
End 07/2022
 
Description IAA funding allocation from EP/R511730/1
Amount £3,835,122 (GBP)
Funding ID EP/R511730/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2021 
End 03/2022
 
Description MRC CiC
Amount £70,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 10/2018
 
Description Mass Spectrometry Imaging of Biomedical Surfaces
Amount £230,000 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 09/2022
 
Description Modulation of immune recognition by P. aeruginosa through engagement of lectin receptors.
Amount £490,000 (GBP)
Funding ID MR/P001033/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Molecular Imaging Strategies for Studying Neurodegenerative Disorders
Amount £230,000 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom
Start 08/2019 
End 07/2022
 
Description NanoPrime: Maximising Equipment and Expertise Sharing in Nanoscience
Amount £202,437 (GBP)
Funding ID EP/R025282/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 07/2021
 
Description Next Generation Biomaterial Discovery
Amount £5,300,000 (GBP)
Funding ID EP/N006615/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2020
 
Description Replacing the need for patient-derived xenografts and matrigel organoid culture as preclinical models for breast cancer
Amount £75,591 (GBP)
Funding ID NC/T001267/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 06/2020
 
Description Sprayable dressings for accelerated wound care with reduced scarring and infection - 2020 MRC funded Confidence in Concept scheme - RA6237, CiC # 8
Amount £747,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2021 
End 10/2021
 
Description Understanding How Matrix Remodelling & Respiratory Infection Impact Progression Of Idiopathic Pulmonary Fibrosis Using Stem Cell Derived Alveolar Cells
Amount £93,000 (GBP)
Organisation British Lung Foundation (BLF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 08/2022
 
Description University Of Nottingham CiC#8 - Translation of novel polymer anti-bacterial coatings to invasive medical devices used in the neonatal intensive care for high risk preterm infants
Amount £118,086 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2021 
End 12/2021
 
Description University of Nottingham - Equipment Account
Amount £15,523,196 (GBP)
Funding ID EP/K005138/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 11/2012 
End 10/2022
 
Description Wellcome Trust: a prestigious 'Sir Henry Wellcome Early Career Fellowship'
Amount £250,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 07/2018
 
Description Wireless communication with cells towards bioelectronic treatments of the future
Amount £974,695 (GBP)
Funding ID EP/R004072/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 04/2023
 
Description Andrew Hook 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution My group provide expertise in glycosaminoglycan structure and function.
Collaborator Contribution Andrew Hook is an expert in surface structural analysis and we are working together to develop methods for the rapid analysis of glycosaminoglycan structures.
Impact Fully funded studentship associated with Andrew's Nottingham Research Fellowship
Start Year 2019
 
Description CamStent 
Organisation Camstent Ltd
Country United Kingdom 
Sector Private 
PI Contribution Discovered new bacteria resistant materials.
Collaborator Contribution Developing and testing the material as a urinary catheter coating.
Impact CE mark gained in 2017- approved for testing in humans.
Start Year 2012
 
Description Collaboration with Daniel Anderson at MIT 
Organisation Harvard University
Department Program of Health Sciences and Technology
Country United States 
Sector Academic/University 
PI Contribution Morgan Alexander and other Post Docs associated to the Programme Grant have worked with Daniel Anderson.
Collaborator Contribution Daniel Anderson has worked with Morgan Alexander and others on the Programme Grant.
Impact None during this programme grant.
Start Year 2015
 
Description Collaboration with David Needham at the University of Southern Denmark 
Organisation University of Southern Denmark
Department Department of Physics, Chemistry and Pharmacy
Country Denmark 
Sector Academic/University 
PI Contribution Felicity Rose, Phil Williams and Post Docs on the programme grant including Marta Alvarez have worked with David Needham.
Collaborator Contribution David Needham has worked with Felicity Rose, Phil Williams and Post Docs on the programme grant including Marta Alvarez.
Impact None yet.
Start Year 2016
 
Description Collaboration with David Winkler 
Organisation Commonwealth Scientific and Industrial Research Organisation
Department CSIRO Materials Science and Engineering
Country Australia 
Sector Public 
PI Contribution Paulius Mikulskis (Post Doc) and Morgan Alexander have worked closely with David Winkler.
Collaborator Contribution David Winkler has worked with Paulius Mikulskis (Post Doc) and Morgan Alexander.
Impact A paper should be coming from this work soon but is not published yet.
Start Year 2016
 
Description Collaboration with Jan de Boer in Maastricht 
Organisation Maastricht University (UM)
Country Netherlands 
Sector Academic/University 
PI Contribution Morgan Alexander and Post Docs on the programme grant (including Britta Koch) have worked with Jan de Boer.
Collaborator Contribution Jan de Boer has worked with Morgan Alexander and Post Docs on the programme grant (including Britta Koch).
Impact None yet but a paper is being written (not published yet).
Start Year 2016
 
Title Bacterial Attachment Microtopographies 
Description patents have been filed to protect a number of findings including in vitro and in vivo instruction of immune cells and bacterial biofilms using both polymer selection and topography 
IP Reference GB2002010.3 
Protection Patent application published
Year Protection Granted 2020
Licensed No
Impact Patents have been filed to protect a number of findings including in vitro and in vivo instruction of immune cells and bacterial biofilms using both polymer selection and topography (GB2002011.1 - Chemical & Microtopography Effects)
 
Title Chemical & Microtopography Effects 
Description patents have been filed to protect a number of findings including in vitro and in vivo instruction of immune cells and bacterial biofilms using both polymer selection and topography 
IP Reference GB2002011.1 
Protection Patent application published
Year Protection Granted 2020
Licensed No
Impact patents have been filed to protect a number of findings including in vitro and in vivo instruction of immune cells and bacterial biofilms using both polymer selection and topography
 
Description "Materials for Virus Binding and RNA Vaccine Formations". Medilink East Midlands Virtual Seminar 25th June 2020. by Prof Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact "Materials for Virus Binding and RNA Vaccine Formations". Medilink East Midlands Virtual Seminar 25th June 2020. by Prof Cameron Alexander

This free to attend webinar was held as part of the INSTILS programme - a project part-funded by the European Regional Development Fund.

Key questions addressed included:
-Why does it take so long to make a new vaccine?
-How might DNA and RNA vaccines disrupt the current process?
-In what ways could the SME sector contribute when vaccines have traditionally been dominated by Big Pharma?
-What are the risks on the way?.

The coronavirus crisis has resulted in an unprecedented acceleration of efforts to develop vaccines. This webinar will cover some of the basic concepts underlying nucleic acid vaccines, and how new materials and formulations might change the way in which vaccines are made and distributed.

DURATION: 1 hour with question and answer session at the end which was well received.
Year(s) Of Engagement Activity 2020
URL https://www.medilinkem.com/event/webinar-materials-for-virus-binding-and-rna-vaccine-formations/
 
Description "Polymer therapeutics - from cancers to vaccines". Keele University Virtual Seminar, 24th June 2020 by Prof Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A seminar given to Keele University via Virtual Seminar on 24th June 2020 by Prof Cameron Alexander entitled "Polymer therapeutics - from cancers to vaccines".
Year(s) Of Engagement Activity 2020
 
Description "Stimuli-responsive polymeric nanomedicines for neuro-oncology" 2nd Workshop on Drug Delivery to the Brain: Edinburgh, 27th February 2020 by Prof Cameron Alexander 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On Thursday 27th February 2020, 73 enthusiastic delegates convened at the Surgeon's Playfair Hall in Edinburgh, UK. The aim was to discuss transformative research that could lead to new, innovative ways of overcoming the challenges of brain tumour drug delivery, particularly in children.

Sponsored by Children with Cancer UK, this was the CBTDDC's (Children's Brain Tumour Drug Delivery Consortium; www.cbtddc.org) second drug delivery workshop. We were delighted to welcome researchers, clinical academics, patient representatives, charities and pharma/biotech companies, all keen to share their rich and varied experience and knowledge.
Year(s) Of Engagement Activity 2020
URL http://www.cbtddc.org/workshop/blog-workshop-2020.aspx
 
Description "Synthetic polymers as bioprobes and therapeutics" - University of Liverpool, March 11th 2020 by Prof Cameron Alexander. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact TBA
Year(s) Of Engagement Activity 2020
URL https://www.liverpool.ac.uk/chemistry/seminars/
 
Description 30th July 2020 - TCES Virtual Seminar Series - Oral presentation: "Xeno-free culture systems for human pluripotent stem cells discovered by high-throughput screening" Dr Aishah Nasir 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation by Dr Aishah Nasir: "Xeno-free culture systems for human pluripotent stem cells discovered by high-throughput screening"

Tissue and Cell Engineering Society conference - Furthering knowledge, research and dissemination of information on Cell and Tissue Engineering
Year(s) Of Engagement Activity 2020
URL https://tces.org/tces-virtual-seminar-series-july-2020/
 
Description 3rd BIRAX Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Chris Denning attended.
Year(s) Of Engagement Activity 2016
 
Description A Science Public Lecture by Professor Morgan Alexander Title: Biomaterials discovery: the journey to clinical application of a novel urinary catheter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A Science Public Lecture
Speaker: Professor Morgan Alexander

Title: Biomaterials discovery: the journey to clinical application of a novel urinary catheter

Abstract: In this talk Professor Alexander will tell the story of his teams discovery of a novel class of biomaterials resistant to bacterial colonisation and biofilm formation from the conception of the initial idea, through to them reaching the clinic and very recent generation of early efficacy results. In the talk Professor Alexander will aim to highlight aspects of the high throughput discovery approach they took, the lessons that can be learned about the many challenges of taking candidate biomaterials from the lab to the clinic.
Year(s) Of Engagement Activity 2021
URL https://mediaspace.nottingham.ac.uk/media/Professor+Morgan+Alexander+-+Biomaterials+discoveryA+the+j...
 
Description APS Industrial Insights Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Dr Marta Alvarez Paino attended.
Year(s) Of Engagement Activity 2016
 
Description Advanced Molecular Materials Research Priority Area (Nottingham) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Internal Publicity: at the University of Nottingham Elizabeth Hudson presented the project to the Advanced Molecular Materials Research Priority Area Sandpit (18/01/16).
Year(s) Of Engagement Activity 2016
 
Description After School Science Club (Nottingham) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A session was delivered at Berridge School, Hyson Green, Nottingham.
Year(s) Of Engagement Activity 2016
 
Description Annual Biomaterials Discovery workshop (Nottingham) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The launch for the Inaugural Biomaterials Discovery Workshop which will be held annually at the University of Nottingham, associated with the recently awarded EPSRC Programme Grant in Next Generation Biomaterials (EP/N006615/1). The second Biomaterials Discovery Workshop will take place in January 2018. The intention is to provide a space for people working in this field to come together and share ideas. Just under 90 people attended this closed workshop with ~300 people attending an open lecture from Daniel Anderson (MIT) as part of this event.
Year(s) Of Engagement Activity 2017
URL http://www.nottingham.ac.uk/research/groups/biomaterials-discovery/events/inaugural-annual-biomateri...
 
Description Biofilm meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Morgan Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description Biomaterials Discovery Website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A project website has been established to communicate the aims and progress of the EPSRC Programme Grant in Next Generation Biomaterials Discovery.
Year(s) Of Engagement Activity 2016
URL http://www.nottingham.ac.uk/research/groups/biomaterials-discovery/index.aspx
 
Description CLINAM Virtual Conference, 27th October 2020. Modifying Drug Carrier Transport through Nanotechnology to Widen the Therapeutic Index by Cameron Alexander. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lectures at International Conferences and Symposia - Modifying Drug Carrier Transport through Nanotechnology to Widen the Therapeutic Index
Year(s) Of Engagement Activity 2020
URL https://www.clinam.org/images/clinam2020/CLINAM_SUMMIT_19.10.20.pdf
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Felicity Rose and Kevin Shakesheff talked about 3D Futures: Building Beating Hearts.
Year(s) Of Engagement Activity 2016
 
Description Computational modelling of biological processes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact July 2016, Nottingham, Dr Aurelie Carlier (MERLN Institute, the Netherlands) held a seminar.
Year(s) Of Engagement Activity 2016
 
Description European Conference on Mathematical and Theoretical Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Morgan Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description First Lego League 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Adam Dundas ran an event as part of the First Lego League on 6th January 2017 at the University of Nottingham.
Year(s) Of Engagement Activity 2017
 
Description Fourth Annual Biomaterials Discovery Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact ~over 100 people attended the Third Biomaterials Discovery Workshop at the University of Nottingham in January 2020. The audience was mainly academic but also PhDs, Post Docs, Industry members etc. The BDW involved some excellent discussions in this area and will continue to be an annual event.
Year(s) Of Engagement Activity 2017,2018,2019,2020
URL https://www.nottingham.ac.uk/research/groups/biomaterials-discovery/news/2020/biomaterials-discovery...
 
Description Gordon Research Conference on 'Biointerface Science' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Britta Koch presented a poster.
Year(s) Of Engagement Activity 2016
 
Description Healthy Aircraft Journeys - Bio-effective surfaces for aeroplanes 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Healthy Aircraft Journeys - Bio-effective surfaces for aeroplanes attended by Morgan Alexander at the Centre for Metamaterial Research and Innovation at the University of Exeter.
Year(s) Of Engagement Activity 2020
 
Description Institute of Infection and Global Health Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Prof Paul Williams gave a Research Seminar.
Year(s) Of Engagement Activity 2016
 
Description International Symposium on Polymer Therapeutics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander chaired a session.
Year(s) Of Engagement Activity 2016
 
Description Joint Sheffield Conference on Chemoinformatics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Paulius Mikulskis attended.
Year(s) Of Engagement Activity 2016
 
Description Leonardo Study Day in Nottingham Castle  
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Researchers from the School of Pharmacy and Faculty of Engineering at the University of Nottingham delivered a Leonardo Study Day in Nottingham Castle. Morgan Alexander, Ricky Wildman, Yinfeng He, Peter Magennis and Andrew Hook delivered the study day for ~120 15-17 year olds. This was part of the Leonardo Da Vinci events at Nottingham Castle, focussing on what the ultimate Renaissance man might be doing in science today. The workshop "Materials for Man: from the idea to a product" was an interactive session with demonstrations to share knowledge and research. Da Vinci was an artist, court engineer, anatomist and inventor and this session illustrated how such interdisciplinary behaviour is now common place in scientific research. Using examples from their own research they showed how this modern interdisciplinary approach using medicine, biology, materials, chemistry, physics, engineering and business has led to the discovery of a new type of plastic which can be used to create products designed to reduce the instances of infections acquired in hospitals.
Year(s) Of Engagement Activity 2016
URL https://www.nottingham.ac.uk/pharmacy/news/archive/2016/university-of-nottingham-hold-the-fort.aspx
 
Description MOBI4Health: Biotech Solutions for Health and Environment Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams attended.
Year(s) Of Engagement Activity 2016
 
Description MRC-DTB Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams gave a Research Seminar.
Year(s) Of Engagement Activity 2016
 
Description Medilink Webinar: Commercial Applications for Next Generation Biomaterials 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This event organised with Medilink Midlands was part of the INSTILS programme - a project part-funded by the European Regional Development Fund,
Medilink UK is a national health technology business support organisation, with a strong track record in increasing the viability of manufacturers, service providers, designers, OEMs and suppliers of medical technology. Medilink UK helps companies from concept through to commercialisation and nurtures collaborations between academics, clinicians and industry.

Presentations were given by several members of the NGBM team including:
- Controlling bacterial biofilms formation using polymers
- Controlling foreign body reaction to medical implants using coatings
- New materials for breast cancer therapies
- Technologies to control Fibrosis

There was a Q&A session after the webinar which was keenly participated in by the audience.

This was an opportunity to partner with industrial partners keen to explore emerging novel biomaterials and their potential in healthcare in short proof of concept studies. Over 50 members from the Midland business community attended. There were a few follow ups by interested companies but no firm activity has taken place yet.
Year(s) Of Engagement Activity 2020
URL https://www.medilinkem.com/event/commercial-applications-for-next-generation-biomaterials/
 
Description Mini-symposium on Nanoscience/nanomedicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact July 2016, Nottingham, Speakers included: Angus Johnston (Monash Institute of Pharmaceutical Sciences), Kris Thurecht (Centre of Advanced Imaging, University of Queensland), Arwyn Jones (Welsh School of Pharmacy, Cardiff) and John McGhee (UNSW Sydney).
Year(s) Of Engagement Activity 2016
 
Description NC3Rs/Unilever joint workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was a scoping workshop to identify opportunities for NC3Rs to work towards the development of animal product free in vitro systems. This involved a variety of industrial and academic partners looking at various 'needs' where we could/should be developing alternatives to animal use. My participation was focused on non-animal alternatives to Matrigel.
Year(s) Of Engagement Activity 2019
 
Description Naked Scientist Podcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This week Andrew Hook spoke to Chris Smith and Izzie Clarke on BBC Cambridgeshire as part of the Naked Scientists show, about the research of the Biomaterials Discovery Group in the bacteria resistant material, currently undergoing clinical trials with Camstent.

The show discusses the chemistry of the developed material, as well as the applications to healthcare and the financial impact it could have. As well as touching upon the wider aspects of the material, including the ongoing clinical trials and potential future applications.
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/research/groups/biomaterials-discovery/news/2019/speaking-on-the-naked-...
 
Description Nanomaterials as Antibiotics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander presented.
Year(s) Of Engagement Activity 2016
 
Description Nottingham Fesitival of Science and Curiosity 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Stand at a local library to share research as part of a city wide festival of science
Year(s) Of Engagement Activity 2020
 
Description Nottingham in Parliament Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Kevin Shakesheff, Paul Williams, Elizabeth Hudson and others attended meetings with selected MPs to discuss, for example, antimicrobial resistance. Events included 'The Future of Healthcare Technologies', 'Health, Life Sciences and Innovation showcase' and 'Developing STEM Skills of the Future.'
Year(s) Of Engagement Activity 2016
URL http://www.nottinghaminparliamentday.uk/
 
Description Participation in "Wonder" - University of Nottingham public engagement festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Wonder is a large-scale event at the University of Nottingham and multiple teams display their work, primarily in research. I contributed to the Biomaterials Discovery team exhibit, which was visited by several hundred people throughout the day. Many expressed surprise that polymers were used so widely in medicine, and multiple comments indicated a change in attitude of some members of the public towards 'plastics'
Year(s) Of Engagement Activity 2017
 
Description Pink of Science (Jamie 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Jamie Thompson was the coordinator for the Nottingham Pint of Science festival in 2018. This involved overseeing multiple outreach events where scientists from lots of research areas spoke and engaged in debate with the public over a week-long festival. The events were very popular with many venues at capacity. The feedback from the public was also very popular and the events had positive write-ups in the local press.
Year(s) Of Engagement Activity 2018
 
Description Pint of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact JT was on the publicity team for Pint of Science 2016-17 and is a co-organiser for Pint of Science 2017-18.
Year(s) Of Engagement Activity 2017
 
Description Pint of Science (May 2018) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Amanda Pearson presented at Pint of Science in May 2018
Year(s) Of Engagement Activity 2018
 
Description Polymer Therapeutics from Cancer to Vaccines". King's College London Virtual Seminar 11th November 2020 by Prof Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Polymer Therapeutics from Cancer to Vaccines". King's College London Virtual Seminar 11th November 2020 by Prof Cameron Alexander
Year(s) Of Engagement Activity 2020
 
Description Poster presentation at World Biomaterials Congress 2020 by R Owen and M Amer 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presented at virtual world congress (https://virtual.wbc2020.org/) originally supposed to be in Glasgow by R Owen and M Amer.
Title: Defined internal geometry microparticles fabricated by two-photon polymerisation for bone tissue engineering
Year(s) Of Engagement Activity 2020
URL https://virtual.wbc2020.org/
 
Description Presentation "Plastics - Will They Destroy or Save the World?" - Wollaton Science Club - March 4th 2020 by Professor Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation "Plastics - Will They Destroy or Save the World?" - Wollaton Science Club - March 4th 2020
Year(s) Of Engagement Activity 2020
 
Description Presentation: New materials for triple-negative breast cancer therapies by Dr Patricia Montiero - 8 Oct 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation given by Dr Patricia Montiero for NBCRC (Nottingham Breast Cancer Research Centre) Seminars - Part of the 'Breast cancer awareness month activities'
https://www.nottingham.ac.uk/research/groups/nottinghambreastcancerresearchcentre/documents/nbcrc-newsletter-sept-2020.pdf

60-70 people attended, the audience was mainly students (undergraduate and postgraduate) and academics from the Schools below.
- Schools - School of Medicine, Life Sciences and Pharmacy. There was a Q&A and discussion session afterwards.
Year(s) Of Engagement Activity 2020
URL https://www.nottingham.ac.uk/research/groups/nottinghambreastcancerresearchcentre/inde
 
Description Recent Appointees in Polymer Science (RAPS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Amanda Pearce presented a poster.
Year(s) Of Engagement Activity 2016
 
Description Research Seminar, Institute of Bacterial Cell Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams gave a research seminar.
Year(s) Of Engagement Activity 2016
 
Description Research Seminar, Sygnature Plc., Biocity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Prof Paul Williams gave a research seminar.
Year(s) Of Engagement Activity 2016
 
Description Royal Society Summer Exhibition 'Plastics Inside Us' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Amanda Pearce (Team Leader for Drug Delivery), Taranjit Singh, Olutoba Sanni, Morgan Alexander, Andrew Hook, Paul Williams, Derek Irvine, Cameron Alexander, Steve Howdle and others were involved in this hands-on exhibit. Visitors could handle medical implants on a full scale human body, test our model antibacterial plastic surfaces by battling against toy microbes and discover what links everyday plastics to life-saving medical devices.
Year(s) Of Engagement Activity 2016
URL https://royalsociety.org/science-events-and-lectures/summer-science-exhibition/exhibits/plastic-insi...
 
Description Royal Society Summer Science Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 13,000 attendees to the week long summer science event held in London. The grant developed and showcased 3 activities and 2 animated videos to the general public and media, with articles being published in the Times and the Telegraph as well as a slot on BBC Health Check regarding our work.

Telegraph Article - "New 'bacteria-phobic' material could stop the spread of superbugs in hospitals"
The Times article - "New catheter cuts infection by keeping bacteria 'happy'"

In 2020 the Royal Society Summer Science Exhibition was ran as a virtual event.
Year(s) Of Engagement Activity 2019,2020
URL https://www.nottingham.ac.uk/research/groups/biomaterials-discovery/royal-society-summer-science-exh...
 
Description Science in the park 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Jamie Thompson was also involved in Science in the Park in March 2017.
Year(s) Of Engagement Activity 2017
 
Description Second Biomaterials Discovery Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact ~over 100 people attended the Second Biomaterials Discovery Workshop at the University of Nottingham in January 2018. The audience was mainly academic but also PhDs, Post Docs, Industry members etc. The BDW involved some excellent discussions in this area and will continue to be an annual event.
Year(s) Of Engagement Activity 2018
URL https://www.nottingham.ac.uk/research/groups/biomaterials-discovery/events/annual-biomaterials-disco...
 
Description Seminar - Synthetic Polymers as Probes and Therapeutics" University of Warwick Virtual Seminar, 27th April 2020 by Prof Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Seminar -Synthetic Polymers as Probes and Therapeutics" given at the University of Warwick - Virtual Seminar, 27th April 2020
Year(s) Of Engagement Activity 2020
 
Description Terasaki Talks: Immune-instructive Materials for Medical Applications by Prof Amir Ghaemmaghami 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Amir Ghaemmaghami presented to the Terasaki Institute online Immune-instructive Materials for Medical Applications July 22 2020
Year(s) Of Engagement Activity 2020
URL https://vimeo.com/449489603
 
Description Third Biomaterials Discovery Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact ~over 100 people attended the Third Biomaterials Discovery Workshop at the University of Nottingham in January 2019. The audience was mainly academic but also PhDs, Post Docs, Industry members etc. The BDW involved some excellent discussions in this area and will continue to be an annual event.
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/research/groups/biomaterials-discovery/news/2019/third-annual-biomateri...
 
Description Tissue and Cell Engineering Society (TCES 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Marta Alvarez Paino presented a poster.
Year(s) Of Engagement Activity 2016
 
Description UK PharmSci Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description UK-China Workshop on Antimicrobial Resistance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams attended.
Year(s) Of Engagement Activity 2016
 
Description UK-India global research challenges workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Morgan Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description University of Monash 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander gave a Lecture.
Year(s) Of Engagement Activity 2016
 
Description University of Nottingham Science Public Lecture: From cancer vaccines to Covid-19 and back - why vaccines for the pandemic may benefit future cancer patients" - December 17th 2020 by Prof Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A virtual Science Public Lecture by Professor Cameron Alexander

Title: From cancer vaccines to Covid-19 and back - why vaccines for the pandemic may benefit future cancer patients

Abstract: The recent deployment of vaccines for Covid-19 has occurred at unprecedented speed, and many have asked how this is possible when most recent vaccines or drugs have taken many years in development. One of the reasons is that some types of vaccine, such as those based on RNA, have in fact, been trialled for a number of years already, but primarily in late-stage cancers. In this talk we will consider how the 'plug-and-play' nature of RNA-based therapeutics allows them to be revised quickly for multiple diseases, and that their widespread adoption for Covid-19 might accelerate trials in other diseases.
Year(s) Of Engagement Activity 2020
URL https://mediaspace.nottingham.ac.uk/media/t/1_cnghpvyw
 
Description Wellcome Trust Researcher Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams gave a Seminar.
Year(s) Of Engagement Activity 2016
 
Description Women In Chemistry Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Conference co-organised by Dara O'Brian for international Women's Day
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/conference/fac-sci/women-in-chemistry/index.aspx
 
Description Wonder 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We invited families to explore the huge range of research and teaching activities that celebrated the Year of the Periodic Table. Activities had a fun link to the elements and ranged from art workshops through to science experiments.
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/wonder/
 
Description Wonder 2019 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We ran a stall at the University of Nottingham's premier outreach event 'Wonder'. We used the stall to highlight two aspects of the group's work. One was the use of peptide hydrogels to create improved models of disease (primarily cancer). The other was the importance of sulphated glycosaminoglycans in health and disease. Both aspects were very popular - we had hands-on exhibits targetted at children and additional information available for older children/adults so we had a lot of engagement and positive feedback. Mostly this was raising the awareness of the importance of the 3Rs in laboratory work and cancer research in particular.
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/wonder/
 
Description Wonder, University of Nottingham 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact On Saturday 17th June the Programme Grant team organised and a ran an event at Wonder 2017 (the University of Nottingham's community event). The Programme Grant event went really well and was called "The amazing material detective and the case of the superbug". 10 Post Docs and ~12 PhD students were involved on the day and over 350 people attended. Associate Prof Felicity Rose also led another event at Wonder regarding regenerative medicine in general.
Year(s) Of Engagement Activity 2017
URL https://www.nottingham.ac.uk/wonder/
 
Description World Biomaterial Congress 2020 - Dec 2020- Oral presentation by Dr Aishah Nasir 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact World Biomaterial Congress 2020 - Dec 2020- Oral presentation by Aishah Nasir (Topography and micropatterning session): "Using high-throughput polymer and micro-topographical biomaterial libraries to identify xeno-free models that mediates maturation of Human Pluripotent Stem Cell Cardiomyocytes",
Year(s) Of Engagement Activity 2020
URL https://virtual.wbc2020.org/events/ondemand?q=Topography&ecategory=&etype=&iCV8b65boAqThCSdA=FE4Jn2O...
 
Description • University of Nottingham Science Public Lecture: From cancer vaccines to Covid-19 and back - why vaccines for the pandemic may benefit future cancer patients" - December 17th 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This was a Public Science Lecture in the University of Nottingham series. Perhaps because of the subject matter (vaccines....) this was the best attended lecture for many years, with over 250 individual log-ins and likely many more watchers.
There were multiple questions, particularly about RNA vaccines, and a number of participants said they were reassured about vaccines and were more likely to be vaccinated as a result. Whether this has translated into actual vaccine take-up isn't known, but the questions indicated an informed but also highly questioning audience.
This was a really rewarding event to do - and I will undoubtedly do more as a result.
Year(s) Of Engagement Activity 2020
URL https://mediaspace.nottingham.ac.uk/media/t/1_cnghpvyw