Next Generation Biomaterials Discovery

Lead Research Organisation: University of Nottingham
Department Name: Sch of Pharmacy

Abstract

Advanced biomaterials are essential components in targeting infectious diseases and cancers, realising the potential of regenerative medicine and the medical devices of the future. A multidisciplinary team spanning Engineering, Science and Medical Faculties in Nottingham, in collaboration with 4 leading international groups has combined to realise the vision of materials discovery in 3D. Without this leap beyond 2D screening methodologies we will miss new advanced materials because they omit architecture and often poorly represent the in vivo environment. The aim is to allow us to move beyond the existing limited range of generic bioresorbable polymeric drug and cell delivery agents currently licensed for use in man and medical device polymers, to bespoke materials identified to function optimally for specific applications.

We know that defining chemistry, stiffness, topography and shape can control the response of cells to materials. This programme will focus on producing and testing large libraries of these attributes in the form of patterned surfaces, particles and more complex architectures. New materials will be identified for application in the areas of targeted drug delivery, regenerative medicine and advanced materials for next generation medical devices.

The 3D screening methods will define a new landscape in biomaterials discovery and create the platforms through which more effective advanced materials will be discovered. Our three ambitious application focussed areas provide high impact examples in which our biomaterials leads are developed towards exploitation in the clinic. These downstream projects will be carried out in both academic and commercial research programmes funded through partnering, licensing and formation of spin-outs as appropriate.

Planned Impact

Beneficiaries from the proposed research will include:

- In the short-term, researchers in the Programme Grant's challenge areas will benefit from the provision of new materials with which to develop biomaterial solutions to healthcare needs. When these materials make their way to the clinic, patients will benefit from improved biomaterials that will result in reduced morbidity and mortality. Clinicians will benefit through the provision of increased treatment options.
- Society will benefit from reduced healthcare costs associated with hospital associated infections, reduced medical implant rejection and improved quality of life for the ageing population.
- Commercial partners in regenerative medicine, the pharmaceutical industry and medical devices will benefit from the generation of new revenue streams associated with new materials which will positively influence the economic competitiveness of the United Kingdom.
- The methodologies developed will have significant impact in the materials scientific research community, facilitating the vision of targeted materials function. These will be applicable beyond healthcare to various sectors including energy, food and manufacturing.
- The researchers involved in the programme and investigators will benefit from highly interdisciplinary training in the growth area of materials and exposure to different ways of working within the UK and international partners.

From a commercial perspective, research is targeted to be directly relevant to 3 broad groups of beneficiaries with whom we have close working relationships established through current research projects:

- In Regenerative Medicine we are collaborating with GE Healthcare, Intercytex, Mica Technologies, Haemostatix, Neusentis, Locate Therapeutics, Neotherix, NCTS, Tokyo Electron and Syngenta.
- In Pharmaceutics, we are collaborating with GlaxoSmithKline, AstraZeneca, Pfizer, Greenpharma, UCB Pharma, PsiOxus, Novozymes, Boots and Molecular Profiles.
- In Medical Devices we are collaborating with Smith and Nephew, Dow Corning, Arterius, Camstent, Protip Medical, Tensive Medical and J&J Visioncare.


Examples of expected outputs include:-

- The discovery of lead material-topography combinations for stem cell differentiation into bone.
- Polymers with the potential to efficiently traffic therapeutics through the body to deliver them preferentially in the vicinity of infections and tumours.
- Mature cardiomyocytes for drug toxicity screening in the pharmaceutical industry.
- Materials which have an immune instructive effect to reduce failure for dental and orthopaedic implants.
- ChemoTopo Chips that will be of use in screening for cell instructive materials in the regenerative medicine industry.
- New 3D models of polymicrobial infections to identify future strategies for preventing/treating chronic infections. This will enable transformational approaches to be taken to meet unmet clinical needs.

Publications

10 25 50

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Alvarez MM (2016) Delivery strategies to control inflammatory response: Modulating M1-M2 polarization in tissue engineering applications. in Journal of controlled release : official journal of the Controlled Release Society

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Amin YY (2016) Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior. in Advanced materials (Deerfield Beach, Fla.)

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Clark EA (2017) 3D printing of tablets using inkjet with UV photoinitiation. in International journal of pharmaceutics

 
Description BBSRC National Biofilms Innovation Centre Innovative Knowledge Centre
Amount £15,600,000 (GBP)
Funding ID BB/R012415/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2022
 
Description EMPIR: 'MetVBadBugs'
Amount € 389,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 06/2016 
End 05/2019
 
Description EPSRC 3D OrbiSIMS: Label free chemical imaging of materials, cells and tissues.
Amount £2,500,000 (GBP)
Funding ID EP/P029868/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 08/2017 
End 07/2022
 
Description EPSRC Thematic Doctoral Training Programme: Bioinstructive materials for healthcare applications (BMHA)
Amount £280,241 (GBP)
Funding ID EP/N50970X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 03/2020
 
Description EPSRC Thematic Studentship
Amount £280,241 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2020
 
Description EPSRC: Engineering Growth Factor Microenvironments
Amount £3,700,000 (GBP)
Funding ID EP/P001114/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2021
 
Description EPSRC: Formulation for 3D printing
Amount £3,800,000 (GBP)
Funding ID EP/N024818/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description EPSRC: Healthcare Technologies Impact Fellowship
Amount £540,000 (GBP)
Funding ID EP/N03371X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 12/2016 
End 11/2018
 
Description Enabling Next Generation Additive Manufacturing for Pharma and related industries
Amount £5,900,000 (GBP)
Funding ID EP/P031684/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2022
 
Description FindABetterWay: Working together
Amount £2,800,000 (GBP)
Organisation Find a Better Way 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2022
 
Description H2020 grant 'Personalised Integrated Biomaterials Risk Assessment (PanBioRA)'
Amount € 7,944,786 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2018 
End 12/2021
 
Description MRC CiC
Amount £70,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 10/2018
 
Description Modulation of immune recognition by P. aeruginosa through engagement of lectin receptors.
Amount £490,000 (GBP)
Funding ID MR/P001033/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Wellcome Trust: a prestigious 'Sir Henry Wellcome Early Career Fellowship'
Amount £250,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 08/2016 
End 07/2018
 
Description CamStent 
Organisation Camstent Ltd
PI Contribution Discovered new bacteria resistant materials.
Collaborator Contribution Developing and testing the material as a urinary catheter coating.
Impact CE mark gained in 2017- approved for testing in humans.
Start Year 2012
 
Description Collaboration with Daniel Anderson at MIT 
Organisation Harvard University
Department Program of Health Sciences and Technology
Country United States 
Sector Academic/University 
PI Contribution Morgan Alexander and other Post Docs associated to the Programme Grant have worked with Daniel Anderson.
Collaborator Contribution Daniel Anderson has worked with Morgan Alexander and others on the Programme Grant.
Impact None during this programme grant.
Start Year 2015
 
Description Collaboration with David Needham at the University of Southern Denmark 
Organisation University of Southern Denmark
Department Department of Physics, Chemistry and Pharmacy
Country Denmark 
Sector Academic/University 
PI Contribution Felicity Rose, Phil Williams and Post Docs on the programme grant including Marta Alvarez have worked with David Needham.
Collaborator Contribution David Needham has worked with Felicity Rose, Phil Williams and Post Docs on the programme grant including Marta Alvarez.
Impact None yet.
Start Year 2016
 
Description Collaboration with David Winkler 
Organisation Commonwealth Scientific and Industrial Research Organisation
Department CSIRO Materials Science and Engineering
Country Australia 
Sector Public 
PI Contribution Paulius Mikulskis (Post Doc) and Morgan Alexander have worked closely with David Winkler.
Collaborator Contribution David Winkler has worked with Paulius Mikulskis (Post Doc) and Morgan Alexander.
Impact A paper should be coming from this work soon but is not published yet.
Start Year 2016
 
Description Collaboration with Jan de Boer in Maastricht 
Organisation Maastricht University (UM)
Country Netherlands 
Sector Academic/University 
PI Contribution Morgan Alexander and Post Docs on the programme grant (including Britta Koch) have worked with Jan de Boer.
Collaborator Contribution Jan de Boer has worked with Morgan Alexander and Post Docs on the programme grant (including Britta Koch).
Impact None yet but a paper is being written (not published yet).
Start Year 2016
 
Description 3rd BIRAX Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Chris Denning attended.
Year(s) Of Engagement Activity 2016
 
Description APS Industrial Insights Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Dr Marta Alvarez Paino attended.
Year(s) Of Engagement Activity 2016
 
Description Advanced Molecular Materials Research Priority Area (Nottingham) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Internal Publicity: at the University of Nottingham Elizabeth Hudson presented the project to the Advanced Molecular Materials Research Priority Area Sandpit (18/01/16).
Year(s) Of Engagement Activity 2016
 
Description After School Science Club (Nottingham) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A session was delivered at Berridge School, Hyson Green, Nottingham.
Year(s) Of Engagement Activity 2016
 
Description Annual Biomaterials Discovery workshop (Nottingham) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The launch for the Inaugural Biomaterials Discovery Workshop which will be held annually at the University of Nottingham, associated with the recently awarded EPSRC Programme Grant in Next Generation Biomaterials (EP/N006615/1). The second Biomaterials Discovery Workshop will take place in January 2018. The intention is to provide a space for people working in this field to come together and share ideas. Just under 90 people attended this closed workshop with ~300 people attending an open lecture from Daniel Anderson (MIT) as part of this event.
Year(s) Of Engagement Activity 2017
URL http://www.nottingham.ac.uk/research/groups/biomaterials-discovery/events/inaugural-annual-biomateri...
 
Description Biofilm meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Morgan Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description Biomaterials Discovery Website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A project website has been established to communicate the aims and progress of the EPSRC Programme Grant in Next Generation Biomaterials Discovery.
Year(s) Of Engagement Activity 2016
URL http://www.nottingham.ac.uk/research/groups/biomaterials-discovery/index.aspx
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Felicity Rose and Kevin Shakesheff talked about 3D Futures: Building Beating Hearts.
Year(s) Of Engagement Activity 2016
 
Description Computational modelling of biological processes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact July 2016, Nottingham, Dr Aurelie Carlier (MERLN Institute, the Netherlands) held a seminar.
Year(s) Of Engagement Activity 2016
 
Description European Conference on Mathematical and Theoretical Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Morgan Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description First Lego League 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Adam Dundas ran an event as part of the First Lego League on 6th January 2017 at the University of Nottingham.
Year(s) Of Engagement Activity 2017
 
Description Gordon Research Conference on 'Biointerface Science' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Britta Koch presented a poster.
Year(s) Of Engagement Activity 2016
 
Description Institute of Infection and Global Health Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Prof Paul Williams gave a Research Seminar.
Year(s) Of Engagement Activity 2016
 
Description International Symposium on Polymer Therapeutics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander chaired a session.
Year(s) Of Engagement Activity 2016
 
Description Joint Sheffield Conference on Chemoinformatics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Paulius Mikulskis attended.
Year(s) Of Engagement Activity 2016
 
Description Leonardo Study Day in Nottingham Castle  
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Researchers from the School of Pharmacy and Faculty of Engineering at the University of Nottingham delivered a Leonardo Study Day in Nottingham Castle. Morgan Alexander, Ricky Wildman, Yinfeng He, Peter Magennis and Andrew Hook delivered the study day for ~120 15-17 year olds. This was part of the Leonardo Da Vinci events at Nottingham Castle, focussing on what the ultimate Renaissance man might be doing in science today. The workshop "Materials for Man: from the idea to a product" was an interactive session with demonstrations to share knowledge and research. Da Vinci was an artist, court engineer, anatomist and inventor and this session illustrated how such interdisciplinary behaviour is now common place in scientific research. Using examples from their own research they showed how this modern interdisciplinary approach using medicine, biology, materials, chemistry, physics, engineering and business has led to the discovery of a new type of plastic which can be used to create products designed to reduce the instances of infections acquired in hospitals.
Year(s) Of Engagement Activity 2016
URL https://www.nottingham.ac.uk/pharmacy/news/archive/2016/university-of-nottingham-hold-the-fort.aspx
 
Description MOBI4Health: Biotech Solutions for Health and Environment Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams attended.
Year(s) Of Engagement Activity 2016
 
Description MRC-DTB Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams gave a Research Seminar.
Year(s) Of Engagement Activity 2016
 
Description Mini-symposium on Nanoscience/nanomedicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact July 2016, Nottingham, Speakers included: Angus Johnston (Monash Institute of Pharmaceutical Sciences), Kris Thurecht (Centre of Advanced Imaging, University of Queensland), Arwyn Jones (Welsh School of Pharmacy, Cardiff) and John McGhee (UNSW Sydney).
Year(s) Of Engagement Activity 2016
 
Description Nanomaterials as Antibiotics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander presented.
Year(s) Of Engagement Activity 2016
 
Description Nottingham in Parliament Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Kevin Shakesheff, Paul Williams, Elizabeth Hudson and others attended meetings with selected MPs to discuss, for example, antimicrobial resistance. Events included 'The Future of Healthcare Technologies', 'Health, Life Sciences and Innovation showcase' and 'Developing STEM Skills of the Future.'
Year(s) Of Engagement Activity 2016
URL http://www.nottinghaminparliamentday.uk/
 
Description Pint of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact JT was on the publicity team for Pint of Science 2016-17 and is a co-organiser for Pint of Science 2017-18.
Year(s) Of Engagement Activity 2017
 
Description Recent Appointees in Polymer Science (RAPS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Amanda Pearce presented a poster.
Year(s) Of Engagement Activity 2016
 
Description Research Seminar, Institute of Bacterial Cell Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams gave a research seminar.
Year(s) Of Engagement Activity 2016
 
Description Research Seminar, Sygnature Plc., Biocity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Prof Paul Williams gave a research seminar.
Year(s) Of Engagement Activity 2016
 
Description Royal Society Summer Exhibition 'Plastics Inside Us' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Amanda Pearce (Team Leader for Drug Delivery), Taranjit Singh, Olutoba Sanni, Morgan Alexander, Andrew Hook, Paul Williams, Derek Irvine, Cameron Alexander, Steve Howdle and others were involved in this hands-on exhibit. Visitors could handle medical implants on a full scale human body, test our model antibacterial plastic surfaces by battling against toy microbes and discover what links everyday plastics to life-saving medical devices.
Year(s) Of Engagement Activity 2016
URL https://royalsociety.org/science-events-and-lectures/summer-science-exhibition/exhibits/plastic-insi...
 
Description Science in the park 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Jamie Thompson was also involved in Science in the Park in March 2017.
Year(s) Of Engagement Activity 2017
 
Description Second Biomaterials Discovery Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact ~over 100 people attended the Second Biomaterials Discovery Workshop at the University of Nottingham in January 2018. The audience was mainly academic but also PhDs, Post Docs, Industry members etc. The BDW involved some excellent discussions in this area and will continue to be an annual event.
Year(s) Of Engagement Activity 2018
URL https://www.nottingham.ac.uk/research/groups/biomaterials-discovery/events/annual-biomaterials-disco...
 
Description Tissue and Cell Engineering Society (TCES 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Marta Alvarez Paino presented a poster.
Year(s) Of Engagement Activity 2016
 
Description UK PharmSci Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description UK-China Workshop on Antimicrobial Resistance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams attended.
Year(s) Of Engagement Activity 2016
 
Description UK-India global research challenges workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Morgan Alexander attended.
Year(s) Of Engagement Activity 2016
 
Description University of Monash 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Cameron Alexander gave a Lecture.
Year(s) Of Engagement Activity 2016
 
Description Wellcome Trust Researcher Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Paul Williams gave a Seminar.
Year(s) Of Engagement Activity 2016
 
Description Wonder, University of Nottingham 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact On Saturday 17th June the Programme Grant team organised and a ran an event at Wonder 2017 (the University of Nottingham's community event). The Programme Grant event went really well and was called "The amazing material detective and the case of the superbug". 10 Post Docs and ~12 PhD students were involved on the day and over 350 people attended. Associate Prof Felicity Rose also led another event at Wonder regarding regenerative medicine in general.
Year(s) Of Engagement Activity 2017
URL https://www.nottingham.ac.uk/wonder/