Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices

Lead Research Organisation: University of Leeds
Department Name: Mechanical Engineering

Abstract

Regenerative devices (scaffolds, biomaterials and interventions) which can repair and regenerate tissues using the patients` own cells, can be translated into successful clinical products and deliver patient benefit at much lower cost and risk and in shorter timescales then other regenerative therapies such as culture expanded cell therapies or molecular (drug) therapies. It is estimated that the global market for regenerative devices will grow to £50bn by 2020 and this offers a real opportunity to grow a £1bn per year industry in the UK in this field.
The UK has genuine research strengths in the areas of biomaterials and tissue engineering, musculoskeletal mechanics (prioritised by EPSRC) and regenerative medicine. Regenerative medicine is one of the eight great technologies prioritised across the Research Councils. Research discoveries, new knowledge, outputs and outcomes are often not ready for uptake by industry to take forward through product development to the market and patient benefit. New technologies need to be advanced and de-risked. The clinical needs, potential products and markets need to be defined in order to make them attractive for investment, product development and clinical trials by industry.

In the Medical Technologies Innovation and Knowledge Centre (MTIKC) Phase 1, working with industry and clinical partners, we have developed a professional innovation team and a unique innovation and translation process, creating a multidisciplinary research and innovation ecosystem. We have successfully identified research outcomes and new knowledge and created, advanced and translated technology across the innovation valley of death, enabling successful investment (over £100m) by industry and the private sector in new product development. Some products have already progressed to clinical trials and commercialisation and are realising patient benefits. We have established a continuous innovation pipeline of over fifty proofs of concept technology projects.

Over the next five years in MTIKC Phase 2, we will address unmet clinical needs and market opportunities in wound repair, cardiovascular repair, musculoskeletal tissue repair, maxillofacial reconstruction, dental reconstruction and general surgery and diversify our research supply chain to over ten other Universities. We will support 150 collaborative projects with industry and initiate forty new industry inspired and academically led proof of concept projects, which are predicted to lead to a further £100m investment by the private sector in subsequent product development. This will enable a sustainable research and product development pipeline to be established in the UK which will support a £1bn / year industry in regenerative devices beyond 2020.

Planned Impact

Economic impact: MTIKC will support the development of a £1bn /year industry in UK, addressing an emergent global market in regenerative devices estimated at £50bn /year. MTIKC will take research outputs at technology readiness level (TRL) 2 and translate them across the innovation valley of death at TRLs 3 and 4. This will be achieved by advancing and de-risking the technology, and defining clinical needs, products, markets and private sector partners to invest in new product development at TRLs 5 to 9 and translate to clinical trials and market. To date MTIKC Phase 1 has demonstrated over £100m direct and indirect private sector investment in the private sector and MTIKC Phase 2 will lead to public and private sector investments in R & D in the UK to support the development and sustainability of a £1bn industry in regenerative devices. The pathway to economic impact includes a strategically focused research and innovation ecosystem based on more than ten Universities in the UK, a dedicated professional innovation team, strong collaborative networks with academia, industry, investors, clinicians, regulators, and NHS and Government agencies. Translation of technology involves a strong multidisciplinary research supply chain, a robust and validated stage-gated innovation process and industry inspired and academically led proof of concept projects, support for patenting, licensing creation, development of spinouts and support for industry collaborations and partnering.

Clinical patient and societal benefits: Society, patients and healthcare providers will benefit from more effective, reliable and cost effective regenerative devices and interventions which address the needs of stratified patient populations with greater levels of precision. Technologies and products supported in the early phases of MTIKC Phase 1, such as self-assembling peptides, acellular human donor tissues and biological scaffolds are already in the market or clinical trials. Enabling technologies- simulation technologies are being used extensively in product development programmes and introduced as international standards. Other new products, technologies and services which will flow from MTIKC by 2020 and beyond.

Transfer of highly trained innovative people and high level skills: Translation and innovation of emergent technologies needs the development and transfer highly skilled people. Technology and scientific training plus innovation and broader skills training is delivered by MTIKC to PhDs through CDTs, to PDRAs through career development programmes and to the wider academic community through specialised workshops. Greater than 75% of our doctoral researchers progress to careers outside academia, with a strong flow of people to our collaborators. Effective collaborative working with industry, either through 300 collaborative projects and 90 POC projects allows the transfer of essential knowledge and skills from university to industry partners. This is supplemented by specialised consultancy advice and access to specialist equipment and skills to industry.

Creation of a more effective pathway for clinical innovation and translation: MTIKC is working with LTHT and LMBRU (see letters of support) on projects to support clinical translation by engaging and training clinical academics and NHS clinicians in early translation. These are important skills and experiences not usually available in the NHS.
Public and patient engagement and influencing policy: This is undertaken collaboratively with NHS, LTHT and LMBRU through their active PPI group. Direct activities with the public are undertaken by the university, with activities in local schools, local and national science fairs. The investigators are also active nationally in both RAEng and EPSRC and regionally in LEP in advising and acting as advocates for the importance of science and innovation.

Organisations

Publications

10 25 50

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Abdelgaied A (2017) A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements. in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

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Abdelgaied A (2018) A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements. in Journal of the mechanical behavior of biomedical materials

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Al-Hajjar M (2019) Combined wear and ageing of ceramic-on-ceramic bearings in total hip replacement under edge loading conditions. in Journal of the mechanical behavior of biomedical materials

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Al-Hajjar M (2017) Wear of composite ceramics in mixed-material combinations in total hip replacement under adverse edge loading conditions. in Journal of biomedical materials research. Part B, Applied biomaterials

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Ali M (2016) Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings. in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

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Anastasiou A (2019) Drug loading capacity of microporous ß-pyrophosphate crystals in Materials & Design

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Bayon Y (2015) Progressing innovation in biomaterials. From the bench to the bed of patients. in Journal of materials science. Materials in medicine

 
Description Our Purpose
As the national centre for medical technology innovation, we are advancing multidisciplinary science and medical technologies, accelerating innovation, reducing technical, regulatory and commercial uncertainty, increasing the downstream investment potential in the development of medical devices and products, delivering economic benefits and future growth in combination with improving the health and wellbeing of an ageing population - fifty active years after fifty. We have a specific focus on regenerative technologies and devices and the related enabling and companion medical technologies. We have an emphasis on medical technology and devices for musculoskeletal disease, dental care, wound care and cardiovascular disease

In ten years since its creation in 2009 (IKC phase one and phase 2)
The MTIKC has developed a distinctive system which integrates and connects all of the following activities to deliver economic and social impact at the end of the value chain.
Concentration of internationally excellent underpinning research and knowledge creation. £140m new research funding, 2661 research papers, 45 patents/licences
Training and develop of graduates and PhDs and PDRAs, progressing to industry healthcare and academia, 150 doctoral researchers and 152 masters graduates
A centre with 55 industry/clinical research partners and an extended group of 202 user partners signed formal agreements, a wider network of 504 members.
A multi professional, multidisciplinary technology innovation management team and process, with experience of research and development from industry and academia
A portfolio of 245 proof of concept, technology development and demonstration projects of which 84 have progressed beyond TRL 4 and to product development
Alternative sources of public funding for technology advancement, innovation projects and innovation management from, ARUK, HEFCE, UKRI Research England £8m
Downstream private sector investment into the private sector for product development, evaluation manufacturing £148m in start-ups and a further £50m into existing industry
A rapidly emerging clinical innovation and evaluation infrastructure in Leeds City Region
Spin out companies. Six new spinouts or start ups
New product development and manufacturing facilities and activities including Tissue Regenix, DePuy Synthes, Invibio, NHS Blood and Transplant, Creavo and Credentis
Provided support for enabling industries such as Simulation Solutions and led the development of new international standards
Exploitation Route . In ten years since its creation in 2009 (IKC phase one and phase 2)
The MTIKC has developed a distinctive system which integrates and connects all of the following activities to deliver economic and social impact at the end of the value chain.
Concentration of internationally excellent underpinning research and knowledge creation. £140m new research funding, 2661 research papers, 45 patents/licences
Training and develop of graduates and PhDs and PDRAs, progressing to industry healthcare and academia, 150 doctoral researchers and 152 masters graduates
The centre has
55 industry/clinical research partners and an extended group of 202 user partners signed formal agreements, a wider network of 504 members.
A multi professional, multidisciplinary technology innovation management team and process, with experience of research and development from industry and academia
A portfolio of 245 proof of concept, technology development and demonstration projects of which 84 have progressed beyond TRL 4 and to product development
Alternative sources of public funding for technology advancement, innovation projects and innovation management from, ARUK, HEFCE, UKRI Research England £8m
Downstream private sector investment into the private sector for product development, evaluation manufacturing £148m in start-ups and a further £50m in existing industry
A rapidly emerging clinical innovation and evaluation infrastructure in Leeds City Region
Spin out companies. Six new spinouts or start ups
Established new product development and manufacturing facilities and activities including Tissue Regenix, DePuy Synthes, Invibio, NHS Blood and Transplant, Creavo and Credentis
Provided support for enabling industries such as Simulation Solutions and led the development of new international standards
Sectors Healthcare

URL http://imbe.leeds.ac.uk
 
Description In ten years since its creation in 2009 (IKC phase one and phase 2) The Medical Technology IKC TIKC has developed a distinctive system which integrates and connects the following activities through out the innovation cycle to deliver economic value and social impact at the end of the value chain. It has Established a concentration of internationally excellent underpinning research and knowledge creation. £140m new research funding, over 2000 research papers, 45 patents/licences Trained and develop of graduates and PhDs and PDRAs, progressing to industry healthcare and academia, 150 doctoral researchers and 152 masters graduates Grown 55 industry/clinical research partners and an extended group of 202 user partners with signed formal agreements and established a wider network of 504 members. A multi professional, multidisciplinary technology innovation management team and process, with experience of research and development from industry and academia A portfolio of 245 proof of concept, technology development and demonstration projects of which 84 have progressed beyond Technology Readiness Level 4 and to product development Alternative sources of public funding for technology advancement, innovation projects and innovation management from, ARUK, HEFCE, UKRI Research England £8m Downstream private sector investment into the private sector for product development, evaluation manufacturing £148m in start-ups and a further £50m into existing industry An clinical innovation and evaluation infrastructure in Leeds City Region Spin out companies. Six new spinouts or start ups created New product development and manufacturing facilities and activities including Tissue Regenix, DePuy Synthes, Invibio, NHS Blood and Transplant, Creavo and Credentis More recently during MTIKC phase 2 since July 2015 The MTIKC has Generated over £40m new research funding to sustain the pipeline of new knowledge creation Trained 101 doctoral students and 117 masters students Collaborated with 49 national and international research partners Collaborated with 202 user organisations Engaged with 55 business partners directly involved in collaborative research and innovation projects, of which 20 are SMEs Conducted 192 different discrete activities and functions held with representative groups to influence the direction or content of research and innovation. Undertaken 42 public or patient engagement events. Generated three new patent families and one new spin out company Undertaken or is undertaking 78 proof of concept or demonstration projects with partners Successfully completed 23 proofs of concept projects which are delivering commercial value to partners as demonstrated by advancement to TRL5 and beyond Private sector industry has invested a further £50 plus into downstream R and D or new manufacturing facilities
First Year Of Impact 2016
Sector Healthcare,Manufacturing, including Industrial Biotechology
Impact Types Societal,Economic

 
Description Chair of ISO TC150/SC4 Bone and Joint Replacements
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact New international standards published, including a test method developed at the University of Leeds (ISO14242-4).
 
Description LCR BIG Panel
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
Impact Membership of local economic partnership Leeds city region , west Yorkshire combined authority business Innovation growth Panel - special advisor on research innovation Universities
 
Description Med ical technology science and innovation audit
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Leadership of Medical Technology science an dInnovation audit, Leeds City region Plus
 
Description Presented 'provocation' and participated in Wellcome Health Exchange - Wellcome Trust discussion on healthy aging research chaired by Eliza Manningham-Buller (Ruth Wilcox)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Provided evidence and represented RAEng at Royal College of Surgeons Commission on the Future of Surgery (Ruth Wilcox)
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://futureofsurgery.rcseng.ac.uk/?_ga=2.204377936.1302407628.1552062378-663961335.1547802634
 
Description Versus Arthritis Advisory group
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Versus Arthritis Research Advisory Group - Ruth Wilcox
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description international standards committee chair
Geographic Reach Asia 
Policy Influence Type Membership of a guideline committee
Impact international pre clinical testing standards
 
Description ARUK
Amount £700,000 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 09/2021
 
Description Apollonia - the next level of dental care
Amount £754,741 (GBP)
Funding ID 133651 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2020
 
Description British Council Newton Fund
Amount £116,000 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2020 
End 02/2021
 
Description CCTMIH Manufacture of Future Fibrous Products Research Fellowship
Amount £250,000 (GBP)
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 03/2019 
End 03/2021
 
Description Capital equipment CDT
Amount £240,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 11/2015 
End 04/2019
 
Description Capital equipment hip and knee simulators
Amount £920,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2015 
End 04/2020
 
Description Catalyst Medical Technologies
Amount £3,000,000 (GBP)
Organisation Higher Education Funding Council for England 
Sector Public
Country United Kingdom
Start 10/2015 
End 10/2018
 
Description Chancellor's Fellow £30k (SHU funding) to support manufacturing of sol-gel based 3D matrices for bone regeneration. (POC057 Sammon Le Maitre SHU)
Amount £30,000 (GBP)
Organisation Sheffield Hallam University 
Sector Academic/University
Country United Kingdom
Start 01/2019 
End 07/2019
 
Description Clothworkers Foundation/UoL - CCTMIH Equipment
Amount £500,000 (GBP)
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 12/2018 
End 12/2019
 
Description Depuy
Amount £300,000 (GBP)
Organisation Depuy International 
Sector Private
Country United Kingdom
Start 01/2016 
End 01/2017
 
Description Development of Next Generations Synergistic Antibiofilm Treatments for Wounds. National Biofilms Innovation Centre
Amount £26,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2019 
End 12/2019
 
Description Dragons den style interview for investment from Sheffield Hallam University and secured £50k to broaden the scope of the research (POC057 Sammon Le Maitre SHU)
Amount £50,000 (GBP)
Organisation Sheffield Hallam University 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description EPSRC
Amount £1,000,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2016 
End 06/2022
 
Description EPSRC
Amount £4,000,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 10/2021
 
Description EPSRC - VaxHub Thermostable Formulations
Amount £192,000 (GBP)
Organisation University of Leeds 
Sector Academic/University
Country United Kingdom
Start 05/2019 
End 07/2020
 
Description Industry Biocomposites
Amount £150,000 (GBP)
Organisation Biocomposites 
Sector Private
Country United Kingdom
Start 07/2015 
End 07/2016
 
Description Industry Invibio
Amount £300,000 (GBP)
Organisation Invibio 
Sector Private
Country United Kingdom
Start 10/2015 
End 10/2017
 
Description Jonathan Jeffers NIHR Research Professorship
Amount £2,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2024
 
Description Key partner in the consortia, consortia lead by M Tryfonidou Utercht University Netherlands. H2020 iPSpine. 15,396,030 Euro (1,126,573 Euro for SHU).(~£13,600,000) (POC057 Sammon Le Maitre SHU)
Amount € 15,396,030 (EUR)
Funding ID H2020 iPSpine 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2019 
End 12/2024
 
Description Medcial engineering centre
Amount £160,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2019
 
Description Proof of Feasibility - EPSRC - University of Leeds IAA
Amount £74,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description RCS Eng. Clinical Research Fellowship - Josh Burke
Amount £60,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Royal Society Research Grant
Amount £14,894 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description The Future Vaccine Manufacturing Research Hub (Vax-Hub)
Amount £191,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2019 
End 01/2021
 
Description White Rose Mucosal Drug Delivery Network
Amount £10,000 (GBP)
Organisation White Rose University Consortium 
Sector Academic/University
Country United Kingdom
Start  
 
Description depuy
Amount £250,000 (GBP)
Organisation Depuy International 
Sector Private
Country United Kingdom
Start 01/2017 
End 01/2018
 
Description epsrc
Amount £1,000,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2020
 
Description invibio
Amount £200,000 (GBP)
Organisation Invibio 
Sector Private
Country United Kingdom
Start 12/2016 
End 12/2018
 
Description lmbrc
Amount £7,500,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 04/2017 
End 04/2022
 
Title Ankle joint simulation 
Description Ankle joint simulation system 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Wear prediction in total ankle joint 
 
Title Biochemical degradation model (McCarthy POC068) 
Description Biochemical degradation model representing in vivo degradation process in mice aiming to reduce number of animals used during degradation studies. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? No  
Impact Biochemical degradation model representing in vivo degradation process in mice aiming to reduce number of animals used during degradation studies. 
 
Title Goat degeneration loading model 
Description Loaded culture system for whole intervertebral discs where controlled degeneration can be induced which mimics disc degeneration seen in humans. (note publication under review) 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2019 
Provided To Others? No  
Impact This model can be used for testing new therapies. 
 
Title ISO standard for wear testing of total ankle replacement 
Description Contribution to an international standard for the assessment of wear performance in total ankle devices. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2019 
Provided To Others? Yes  
Impact New standard to which all future ankle replacement designs must be tested prior to clinical study. 
URL http://www.iso.org/standard/73612.html
 
Title Knee joint simulator 
Description artificial knee joint simulator 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Simulator and simulation method commercialised by simulation solution 
 
Title Method to assess early phase of cartilage degeneration (POC041 J Dudhia) 
Description RAMAN spectroscopy method t assess early cartilage damage and degradation for use in Clinical practise or research 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? No  
Impact none yet - still in development 
 
Title MicroTissue in vitro model 
Description Cell pelletes were used incombination with 3D printed scaffold for MicroTissue in vitro model to enhance tissue engineering efficacy. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact This method could help to establish new in vitro model for replacement of animal used and help for investigate tissue engineering stratagy in 3D. 
 
Title Natural knee simulator 
Description Simulation system for natural knee 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Simulator commercially available, Simulation Solutions 
 
Title New Freeze Drier for development of Chitosan Scaffolds 
Description New Freeze Drier acquired to enable development of Chitosan Scaffolds for periodontal regeneration 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact The equipment enabled the research to be conducted 
 
Title Patellar simulation 
Description Simulation of mechanics and wear of patellae femoral joint 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2015 
Provided To Others? Yes  
Impact Determination of wear in patellar femoral joint 
 
Title Simulation of bone healing within the ostotomy gap (BJR publication) 
Description Simulation of bone healing within the ostotomy gap (BJR publication) 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2019 
Provided To Others? Yes  
Impact Improved method 
URL https://www.ncbi.nlm.nih.gov/pubmed/30662711
 
Title development of a novel bioreactor for peridontal tissue engineering 
Description A novel in vivo bioractor has been developed to apply mechanical simulation to the cell-scaffold constructs to mimic peridontal enviroment to enhance the regeneration of periodontal tissues. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact To enhance the efficacy of peridontal tissue regenration which will have impact for clinical translation. 
 
Title natural hip simulator 
Description Simulation system for natural hip 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2014 
Provided To Others? Yes  
Impact System commercially availa le from Simulation Solutions 
 
Title Biomechanical and biotribological simulation model natural hip 
Description Biomechanical and biotribological model of natural hip 
Type Of Material Computer model/algorithm 
Year Produced 2013 
Provided To Others? Yes  
Impact used in follow on research 
 
Title Biomechanical model of functional spinal unit 
Description model of functional spinal unit 
Type Of Material Computer model/algorithm 
Year Produced 2014 
Provided To Others? Yes  
Impact used in follow on research 
 
Title Biotribological model naturala knee 
Description Biotribological model natural knee 
Type Of Material Computer model/algorithm 
Year Produced 2014 
Provided To Others? Yes  
Impact Used in follow on research on regenerative devices 
 
Title Drug loading capacity of microporous ß-pyrophosphate crystals - dataset 
Description Periodontitis and peri-implantitis are two characteristic examples where bacterial infections compromise the healing of dental tissues. Drug eluting scaffolds are a potential solution to this problem but their fabrication requires suitable biomaterials with significant drug loading capacity and regenerative potential to support new tissue formation. With this aim, porous ß-pyrophosphate crystals having a micro-pore area of 2.59 m2/g and an average pore diameter of 65 nm, have been obtained by the heat treatment of brushite (at 780 oC). To demonstrate the drug loading potential of the mineral, experiments with chloramphenicol have been conducted. After tests with four common bacteria, the drug loaded mineral was shown to have enhanced antibacterial properties, particularly towards E. coli (74% growth inhibition) and S. aureus (48% growth inhibition). Taking into account ß-pyrophosphate's significant role in hard tissue mineralisation and the capability to tailor crystal micro-porosity characteristics by controlled heat treatment, the mineral can be considered as an ideal biomaterial for localised drug delivery in dental applications. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Title IKC POC0053 - VFA (Vertebral Fracture Analysis) 
Description Synthetic shape model of the vertebral fracture modes merged with the statistical shape model of the spine. Method for the sampling of synthetic spines with fracture. Method for the projection of the 3D model into a VFA-like 2D projection. This will be used to further train the fracture assessment algorithm for improving its accuracy. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? Yes  
Impact Improved main algorithm speed. Developed automatic landmark location - implementing a method which should allow to automatically locate the intervertebral disc centres from one or two manually identified centres. The method is based on statistical models of shape and appearance. A first version requiring the manual identification of two vertebrae is implemented. An advanced version requiring only one manual vertebra identification is being explored. 
 
Title VFA (Vertebral Fracture Analysis) Image repository - XNAT 
Description Database repository implementation to be completed by Nov 2018 - ongoing 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Dec 18 - All fracture and non-fracture cases have been identified.(500). All VFA and DXA images have been retrieved, anonymised and uploaded to the XNAT server. 
 
Description Amsterdam 
Organisation VU University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Knowledge on intervertebral disc degeneration and pathogenesis. Novel therapies for new treatments
Collaborator Contribution Loading environment and culture systems for modelling intervertebral disc
Impact none yet
Start Year 2017
 
Description Ceramisys Ltd (POC049 - Miller) 
Organisation Ceramisys
Country United Kingdom 
Sector Private 
PI Contribution The research are working to validate a new range of bone filler material.
Collaborator Contribution The partner provide industrial processed material for testing. The partner brings regulatory, manufacturing and marketing knowledge regarding this med tech sector.
Impact The project brings research experience from engineering, dentistry and microbiology.
Start Year 2016
 
Description Collaboration with Credentis to support commercialisation of self assembling peptide P11-4 
Organisation Credentis
Country Switzerland 
Sector Private 
PI Contribution Provided data to support regulatory approval of product in USA
Collaborator Contribution Credentis provide expertise, technical support and supply test materials (SAPs)
Impact Multidisciplinary collaboration bringing together bioogy, chemistry, business, dental and oral biology.
 
Description Collaboration with David Russell within an MD supervision project 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Student: SR, Leeds General Infirmary
Collaborator Contribution Student: SR, Leeds General Infirmary
Impact None known
Start Year 2019
 
Description Corin 
Organisation Corin Group PLC
Country United Kingdom 
Sector Private 
PI Contribution research
Collaborator Contribution funds time materials
Impact multidisciplinary engineering medicine
Start Year 2016
 
Description Cytori Ltd (POC046 - Jayne) 
Organisation Cytori Ltd
Country United Kingdom 
Sector Private 
PI Contribution The research team have provided additional validation of the company's cell separation system against a manual system and for an alternative tissue type.
Collaborator Contribution The partner have provided free of cost use of cell separation system and reduced reagent cost.
Impact The collaboration involved researchers from chemical & process engineering, biomedical sciences and colorectal surgery.
Start Year 2016
 
Description DePuy partnership 2016 
Organisation Depuy International
Country United Kingdom 
Sector Private 
PI Contribution Research supply
Collaborator Contribution Research funding cash, materials and in kind
Impact publications IP multidisciplinary, engineering medicine biology
Start Year 2016
 
Description DePuy partnership 2017 
Organisation Depuy International
Country United Kingdom 
Sector Private 
PI Contribution Research supply
Collaborator Contribution Funding, materials , know how, staff time
Impact publications multidisciplinary engineering biological sciences, medicine
Start Year 2017
 
Description Depuy Kennedy 16-17 
Organisation Depuy International
Country United Kingdom 
Sector Private 
PI Contribution Knowledge advice
Collaborator Contribution knowledge expertise
Impact multidiciplines engineering medicine
Start Year 2016
 
Description Depuy Nutter 16-17 
Organisation DePuy Synthes
Country United States 
Sector Private 
PI Contribution Research , knowledge advice
Collaborator Contribution advice , knowledge
Impact knowledge advice multidisciplinary engineering biology medicine
Start Year 2016
 
Description Edwards Powell 2016-17 
Organisation Edwards Lifesciences Corporation
Country United States 
Sector Private 
PI Contribution knowledge advice
Collaborator Contribution advice expertise
Impact multidisciplinary engineering , mediicne
Start Year 2016
 
Description LTHT 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution research
Collaborator Contribution facilities, materials implants data
Impact engineering medicine
Start Year 2016
 
Description Medacta industry relationship 
Organisation Medacta
Country Switzerland 
Sector Private 
PI Contribution CDT Student at University of Leeds Institute of Medical and Biological Engineering
Collaborator Contribution Raw materials, visits to Medacta, internship in Summer 2020 and support from their engineers in this project
Impact During the initial period of the iSMART project our team has revisited a number of design criteria based on the legislation and Medical Devices regulations. This with input from our Industrial collaborators Medacta has resulted in the project aiming to achieve a device intended to be placed centrally within the polyethylene insert. A number of experiments have shown that the measurement of forces using this novel approach is possible. We have selected and individually tested electrical components that will make the overall device possible within the confined space allowed/possible. Having tested these as a macro prototype circuitry the next stage will be to scale down the size of the electrical circuitry through PCB board design and testing.
Start Year 2019
 
Description Montreal Loaded Disc Culture System 
Organisation McGill University
Department Montreal Children's Hospital Research Institute
Country Canada 
Sector Academic/University 
PI Contribution Collaboration on human loaded disc culture system, and development of organ system for testing materials in human IVDs. Contribution of knowledge of Human disc degenration, culture systems and mimiking in vivo environment. Testing of new materials.
Collaborator Contribution Loaded disc culture system, and personnel working on collaborative project.
Impact None yet
Start Year 2019
 
Description NAMSA 
Organisation North American Science Associates Inc
Country United States 
Sector Private 
PI Contribution In vivo testing of dCell bone to detremine osseointegration and biocompatibility
Collaborator Contribution undertaking research work
Impact pubication
Start Year 2015
 
Description NHSBT 
Organisation NHS Blood and Transplant (NHSBT)
Department National Blood Service
Country United Kingdom 
Sector Public 
PI Contribution Research
Collaborator Contribution funding, materials and time
Impact publications multidisciplinary engineering biology
Start Year 2016
 
Description National Blood Service 
Organisation NHS Blood and Transplant (NHSBT)
Department National Blood Service
Country United Kingdom 
Sector Public 
Start Year 2003
 
Description Neotherix 
Organisation Neotherix Ltd
Country United Kingdom 
Sector Private 
PI Contribution Repair of oral and peridontal defects using regenerative and antibacterial strategies delivered by a novel tissue scaffold vehicle Polymeric scaffolds functionalised for periodontal repair
Collaborator Contribution materials
Impact multidisciplinary
Start Year 2015
 
Description New collaboration with Prof Olivo Sandro at UCL (POC041- J Dudhia) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Exploring potential for combining Raman spectroscopy with x-ray phase contrast imaging of cartilage
Collaborator Contribution Bringing expertise in x-ray phase contrast imaging
Impact None as yet
Start Year 2018
 
Description Onoging link with NuVision Biotherapies Ltd 
Organisation NuVision
Country United Kingdom 
Sector Private 
PI Contribution Research facilities and knowledge
Collaborator Contribution Manufacturing facilities and knowledge
Impact None stated
Start Year 2016
 
Description PBC Biomed 
Organisation PBC Biomed
Country Ireland 
Sector Private 
PI Contribution None stated
Collaborator Contribution Letter of support
Impact The industrial partner, PBC Biomed, is involved in accelerating the translation and commercial development of the medical device technology
Start Year 2019
 
Description Paul Rooney (NHSBT Tissue & Eye Services) 
Organisation NHS Blood and Transplant (NHSBT)
Country United Kingdom 
Sector Public 
PI Contribution See outputs
Collaborator Contribution See outputs
Impact Ongoing collaboration with NHS Blood & Transplant Tissue & Eye Services (Prof Paul Rooney) on translation of decellularised tissues into the clinic
Start Year 2019
 
Description Renishaw Plc 
Organisation Renishaw PLC
Country United Kingdom 
Sector Private 
PI Contribution Secondment project for Dr Riana Guifulina
Collaborator Contribution Consultancy and advice on probe development or of existing technology that may be suited for our purposes. They will also provide advice and knowhow on one of their latest small footprint Raman instruments to link up with a fibre optic probe. We are aiming to pursue these directions once we renew our formal collaboration agreement with Renishaw
Impact Through our collaboration with Professor Geraint we established interactions to fund and organise a secondment project for Dr Riana Guifulina to validate cartilage spectra on their new mapping Raman instrument. This was established through a NDA between all parties. We will next discuss a potential collaboration to test fibre optic probes for clinical applications
Start Year 2019
 
Description Sheffield Children's Hospital 
Organisation Sheffield Children's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Dr Amaka Offiah (Consultant Paediatric Radiologist)
Collaborator Contribution Dr Offiah has attended 2 x quarterly project meetings (first and last) and provided comments.
Impact Reviewed and approved the VERDICT mock-up
Start Year 2017
 
Description Sheffield Teaching Hopsitals NHS Foundation Trust 
Organisation Sheffield Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution IKC POC0053 - Dr Nicola Peel, Prof Richard Eastell, Professor Eugene McCloskey, Dr Jennifer Walsh, Dr Mary Bull (Consultants in Metabolic Bone Disease) Dr Sarah Gowlett (Consultant Musculoskeletal Radiologist)
Collaborator Contribution Interviews, working groups.
Impact Mock-up of an automated vertebral fracture identification tool presented to Radiologists (Dr Sarah Gowlett) in Sheffield (14 Feb 2018).
Start Year 2017
 
Description Simsol2016 
Organisation Simulation Solutions
Country United Kingdom 
Sector Private 
PI Contribution Research
Collaborator Contribution equipment , staff time, expertise
Impact multidisciplinary engineering medicine
Start Year 2016
 
Description Supply of GMP Collagen 
Organisation Collagen Solutions
Country United Kingdom 
Sector Private 
PI Contribution Information of collagen materials manufacturing
Collaborator Contribution FoC supply of commercial grade GMP collagen
Impact Manufacture of collagen fibres and gels
Start Year 2014
 
Description Tissue 
Organisation Tissue Regenix Ltd
Country United Kingdom 
Sector Private 
PI Contribution Research
Collaborator Contribution materials
Impact multidisciplinary engineering biology
Start Year 2016
 
Description Tissue Regenix Ltd 
Organisation Tissue Regenix Ltd
Country United Kingdom 
Sector Private 
PI Contribution research
Collaborator Contribution materials Ip
Impact papers
Start Year 2014
 
Description Vascutec 
Organisation Vascutek Ltd
Country United Kingdom 
Sector Private 
PI Contribution Heart valve conduit
Start Year 2010
 
Description Xiros Ltd (including support for CDT studentship) 
Organisation Xiros Ltd
Country United Kingdom 
Sector Private 
PI Contribution Expertise in method development for evaluation of repair materials for ankle ligaments
Collaborator Contribution Access to data and input from industrial and clinical perspectives
Impact To date, abstracts at the British Orthopaedic Research Society meeting. Publications under review - not yet published.
Start Year 2016
 
Description collaboration with Prof Geraint Thomas at UCL 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-investigators on new grants - BBSRC (£350,000) and UCLB (£62,000)
Collaborator Contribution Expertise in Raman spectroscopy and industry links
Impact Co-investigators on new grants - BBSRC (£350,000) and UCLB (£62,000)
Start Year 2017
 
Description invibio 2016 
Organisation Invibio
Country United Kingdom 
Sector Private 
PI Contribution research
Collaborator Contribution funds, time, materials
Impact multidiciplinary
Start Year 2016
 
Title Composite connective Tissue and Bone Implants 
Description Method for the decellularisation of bone-meniscus-bone; bone-tendon-bone and bone-cartilage 
IP Reference WO2014037713 
Protection Patent application published
Year Protection Granted 2013
Licensed No
Impact Proof of concept phase in large animal model completed for bone-tendon-bone, discussions ongoing with a company on development re licensing
 
Title Corneal tissue 
Description Corneal tissue - filed 13 November 2019 
IP Reference GB1916506.7 
Protection Patent application published
Year Protection Granted
Licensed No
Impact Not known
 
Title NOVEL PEPTIDE COMPLEXES 
Description The invention relates to novel self-assembling peptide complexes comprising a charged peptide and a polysaccharide, methods of producing them and uses therefor. The novel self-assembling peptide complexes of the present invention have particular utility in the restoration of biomechanical or biochemical function of a variety of biological tissues, for example and without limitation, in degenerated spinal discs, osteoarthritic joints, damaged cartilage, meniscus, ligaments, tendons, dental, ophthalmic and cardiovascular and blood vessel tissues. The invention provides inter alia methods of repairing and or restoring biomechanical or biochemical function of biological tissues and scaffolds for the support of cell growth. 
IP Reference US2016058871 
Protection Patent granted
Year Protection Granted 2016
Licensed No
Impact Follow on funding obtained for first in vivo study
 
Title Theagen(TM) Granted (Sidney POC064) 
Description Trademark for Theagen(TM) name granted (Sidney POC064) 
IP Reference  
Protection Trade Mark
Year Protection Granted 2018
Licensed No
Impact Trademark for Theagen(TM) name granted
 
Title VERDICT 
Description The current version of the prototype for 3D vertebral reconstruction and fracture assessment include method implementation and interface design (Frangi et al). It will be progressively updated until the last prototype version at the end of the project. SEP 18 Started the development of the graphical interface for VERDICT 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2018
Licensed No
Impact The current version of the prototype for 3D vertebral reconstruction and fracture assessment include method implementation and interface design (Frangi et al). It will be progressively updated until the last prototype version at the end of the project. SEP 18 Started the development of the graphical interface for VERDICT
 
Title Arthroscopic device for stimulating synovial mesenchymal stem cells in the knee 
Description The arthroscopic device is currently (as of Jan 2017) in a small scale clinical evaluation study at Leeds Teaching Hospitals funded through NIHR funded Leeds Musculoskeletal Biomedical Research Unit, led and managed by Prof Dennis McGonagle, Dr Tom Baboolal with Consultant Mr Owen Wall. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact IKC funded Proof of Concept (POC) Project supported early development of the new medical device. This supported device design and testing, prototype manufacture and subsequent manufacture of devices for use in the clinical evaluation. The POC also supported generation of data used in patent filing. 
 
Title Automated Identification of Osteoporotic Vertebral Fractures: VERDICT 
Description A standard computerised approach that can reliably detect and analyse spinal fractures in patients with osteoporosis First Verdict prototype for clinical testing, and user interface mockup (V6) Also developed video mock-up for More efficient communication. 2nd prototype ongoing 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact Unknown (11/03/2019) 
 
Title Novel crosslinked chitosan/PNIPAAM hydrogel loaded with positively charged RALA/hydroxyapatite NPs for bone regeneration (McCarthy POC068) 
Description Novel crosslinked chitosan/PNIPAAM hydrogel loaded with positively charged RALA/hydroxyapatite NPs for bone regeneration 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact Novel crosslinked chitosan/PNIPAAM hydrogel loaded with positively charged RALA/hydroxyapatite NPs for bone regeneration 
 
Title POC052- Perry 
Description Osteoarthritis is a painful condition that affects joints, where the surfaces within the joints become damaged so they don't move as smoothly as they should. The most commonly identified cause of osteoarthritis in patients under 60 years old is a condition called developmental dysplasia of the hip, where the hip doesn't develop properly from birth. However, if diagnosed early, this condition is easily treatable and can prevent osteoarthritis from developing later in life. The SHINE study: Screening The Hips In NEwborns aims to develop an acoustic test to detect developmental dysplasia of the hip in newborn babies. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact
 
Title Porcine Acellular Bladder Matrix biomaterial - (POC045 - Southgate) 
Description The device has undergone auto-augmentation bladder surgery in a porcine pre-clinical trial. The surgery was successful and qualitative analysis of tissue healing shows the device to be successful. Further quantitative analysis is on-going. This project has been funded via IKC POC funding £100k(FeC). The collaborative company Tissue Regenix will be approached for further support of the technology development. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2017
Development Status Under active development/distribution
Impact This device has many possible clinical applications due to unique elastic/ flexible properties and the apparent success at which the device has been shown to promote urinary tissue integration on healing. The primary application under investigation is for paediatric auto-augmentation bladder surgery. There are currently no suitable products on the market to address this clinical need. It is anticipated that, if satisfactorily addressed, this technology could provide a life-long solution for paediatric patients requiring this complex surgery. 
 
Title Raman arthrospectroscopy for intra-operative mapping of early articular articular cartilage damage (J. Dudhia PO041) 
Description Raman arthrospectroscopy for intra-operative mapping of early articular articular cartilage damage is being developed in by Dr J. Dudhia at RVC and Prof P. McMillan at UCL. This technology is currently in Proof of concept stage in development and is funded through Arthritis Research UK (Versus Arthritis) in collaboration with the IKC. The POC project aims to improve the signal to noise, reduce imaging time and produce a commercialisable prototype. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2016
Development Status Under active development/distribution
Impact The research team are actively developing collaborations with commercial organisations and are developing partnership with Renishaw to provide the small diameter fibre optic Raman probe. 
 
Title TOKA high tibial osteotomy plate and surgical guides 
Description In silico clinical trials completed and currently securing funding and ethical approval for first in man clinical trials. 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact Device and company have undergone MHRA registration and company has completed ISO:13845 BSI accreditation 
 
Title acellular bone 
Description under development and in in vivo trials 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under development and in animal trials 
 
Title acellular bone cartilage osteochondral graft 
Description under development 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under developemnt 
 
Title acellular bone cartilage osteochondral graft 
Description under development NHSBT 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact under development 
 
Title acellular bone patellar bone graft 
Description under development by NHSBT 
Type Therapeutic Intervention - Surgery
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact under development by NHSBT 
 
Title acellular dcell vascular patch 
Description licensed to and commercialised by Tissue Regenix 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Clinical Trial? Yes
Impact First dcell clinical product 
URL https://clinicaltrials.gov/show/NCT00958230
 
Title acellular dcell dermis 
Description commercialised by Tissue regenix from 2014 
Type Therapeutic Intervention - Medical Devices
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact sold and distributed in USA 
 
Title acellular dermis 
Description supplied as clinical product by NHSBT 
Type Therapeutic Intervention - Surgery
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact supplied by NHSBT, improved wound healing in chronic leg ulcers 
 
Title acellular heart valve 
Description clinical application through human tissue bank 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact proof of clinical use acellular technology 
 
Title acellular vascular graft 
Description under development by NHSBT and Tissue Regenix 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact Under development by NHSBT an dTissue Regenix 
 
Title dcell ligament 
Description Under commercial development by tissue Regenix, progressing to CE mark and product launch 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact under commercial development by Tissue Regenix in clinical trial started 2015 proceeding to Ce mark and product launch 2017 
URL https://clinicaltrials.gov/show/NCT02540811
 
Title dcell meniscus 
Description Developed by tissue Regenix In clinical trial started 2015 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact first in man clinical trial started 2015 
URL https://clinicaltrials.gov/show/NCT02270905
 
Title iSMART - Instrumented Sensor Module for Arthroplasty Treatment 
Description The iSMART (Instrumented Sensor Module for Arthroplasty Treatment) will offer early detection of poorly performing implants, through changes in force, motion and temperature revolutionising how patients interact with their recovery, providing a means to collect, access and analyse meaningful data remotely and intervene as appropriate. This will provide improved post-operative care with greater convenience to the patient and reduced burden on healthcare services 
Type Therapeutic Intervention - Medical Devices
Year Development Stage Completed 2019
Development Status Under active development/distribution
Impact iSMART device incorporates measurements that will be useful as a diagnostic tool in Total Knee Replacement performance in vivo. Testing has shown that a novel approach of measuring forces centrally within a polethylene component of a TKR can provide useful information. iSMART will be a medical device intended for incorporation/inclusion in current technology i.e. TKR implanted during Surgery. This will aid in the recovery process (therapeutic) as well as in behavioural risk modification. The potential data collected by the iSMART device will be of great benefit to the development of TKR Designs in the future. 
 
Title New method for quantitative image analysis 
Description Researcher working on POC project worked with company, TissueGnostics, to develop new quantitative image analyses 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2018 
Impact New quantitative image analyses 
 
Title TOKA High tibial Osteotomy Software prototype 
Description The software package supports the development and planning of personalised high tibial osteotomy device, accurate surgical cutting jig and aids in planning the surgical procedure to ensure successful outcomes. It will improve and make the surgery more accurate while also easier to perform and save time. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2018 
Impact makes the operation easier for surgeons to perform. Personalised cutting guides and fixation plates will improve accuracy and surgical outcome. The software, cutting guide and fixation plate will reduce operation times. It is expected to benefit patients by improving knee osteoarthritis symptoms, provide an alternative to total knee replacement and solves many of the issues currently observed with HTO currently. 
 
Title ankle joint simulator 
Description ankle joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2015 
Impact support product development 
 
Title finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort 
Description This project has been led by Dr Ruth Wilcox in partnership with Simpleware Limited. The development of the software add-on has been completed and the final validations with the Leeds data set-set are coming to an end. It is anticipated that a technology demonstrator project will now be undertaken with a company that can demonstrate the utility of the software for evaluating spinal implants. The commercial team is now engaged and discussions with Simpleware around a possible license deal are on-going. It is envisaged that as part of this license deal Simpleware will engage Leeds expertise as part of their offer to companies. In addition Leeds personnel will retain the right to undertake consultancy in their own capacity. 
Type Of Technology Software 
Year Produced 2013 
Impact further research 
 
Title hip joint simulator 
Description hip joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2012 
Impact commercial product Simulation solutions 
 
Title knee joint simulator 
Description knee joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2013 
Impact Commercial product simulation solutions 
 
Title natural hip simulator 
Description natural hip simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2014 
Impact commercial product simulation solutions 
 
Title natural knee simulator 
Description natural knee simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2013 
Impact commercialised by simulation solutions 
 
Title patellar simulator 
Description patellar femoral joint simulator 
Type Of Technology Physical Model/Kit 
Year Produced 2009 
Impact Support for new product development 
 
Company Name CELL LANE LIMITED 
Description Cell Lane Ltd develops a cell isolation and separation platform. The platform offers assistance in the treatment of chronic diseases such as cancer and AIDS, and is intended to enable new fields of research in research activities, such stem cell research. The company was incorporated in 2017 and is based in Chester, United Kingdom. 
Year Established 2017 
Impact 16/07/2019
 
Company Name ADDITIVE INSTRUMENTS LIMITED 
Description manufactures surgical instruments by additive manufacture 
Year Established 2019 
Impact None recorded
Website https://www.additiveinstruments.com/
 
Description 'Be Curious' University of Leeds Public Engagement event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Science fair style activities demonstrating the research on-going within the institute, primarily focussed on total joint replacement. 10 research staff and post-doctoral students engaged with members of the general public through this one-day event
Year(s) Of Engagement Activity 2016
 
Description 30th Annual Meeting of the Wound Healing Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation by Dr. Tronci on Photoactive Type I (atelo) collagen as Building Blocks of Advanced Wound Dressings
Year(s) Of Engagement Activity 2018
 
Description 3D DTA training course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Workshop for PhD students from doctoral training alliance on 3D cell culture, lead to other collaborations and supporting students around the country
Year(s) Of Engagement Activity 2019
 
Description 3D MedLIVE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A partnership between 3DMedNet and the Journal of 3D Printing in Medicine. The event convenes members of the community who, together, can make 3D printing in surgical practice an everyday reality in many hospitals.

Case studies from pioneering surgeons and researchers who are already utilising this technology in their practice, plus panel discussions and roundtables with regulators, manufacturers and funders.
Year(s) Of Engagement Activity 2019
 
Description 3D-printed implants and scaffold technology - how bioengineering innovation could treat and prevent osteoarthritis 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Online news article as part of Arthritis Research UK's Arthritis Today Winter 2017 no.174
Year(s) Of Engagement Activity 2017
URL https://www.arthritisresearchuk.org/news/arthritis-today/2017/november/3d-printed-implants-and-scaff...
 
Description ARUK Arthritis Today - 3D-printed implants and scaffold technology 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Continuing collaboration with ARUK (now Versus Arthritis). Website article highlighting two case studies where Arthritis Research UK has invested in innovative research dedicated to developing medical technologies:
At UCL - a scaffold type device which can be implanted into a damaged joint to create an environment in which cartilage can reform
The development of ToKa®: A High Precision Patient Specific High Tibial Osteotomy Procedure at the University of Bath
Year(s) Of Engagement Activity 2017
URL https://www.arthritisresearchuk.org/news/arthritis-today/2017/november/3d-printed-implants-and-scaff...
 
Description ARUK Winter Warmer 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Fundraising leaflet in collaboration with ARUK (now Versus Arthritis)
Year(s) Of Engagement Activity 2017
 
Description Alex Frangi Chair Announcement 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Article on University of Leeds website about the Chair in Emerging Technologies awarded to Professor Alex Frangi by the Royal Academy of Engineering.
Year(s) Of Engagement Activity 2019
URL https://www.leeds.ac.uk/news/article/4403/using_virtual_populations_to_create_safer_medical_devices?...
 
Description Announcement of Proof of Concept project -Colorectal HTC website & newsletters (POC046 - Jayne) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A press release detailing a proof of concept project, in collaboration with an industrial partner, would seek to address a life threatening unmet clinical need related to bowel surgery. This press release was announced in the newsletter and website of the Colorectal Health Technology Cooperative.
Year(s) Of Engagement Activity 2016
URL http://colorectal.htc.nihr.ac.uk/latest-news/colorectal-wound-healing/
 
Description Announcement of SIPF seedcorn winners 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact UKRI have now published details of the SIPF Wave 1 bids awarded seedcorn funding. Medical Technologies in the Leeds City Region: Driving economic growth, improving health and care.
Year(s) Of Engagement Activity 2019,2020
 
Description Ask the Expert - Clinically Led Manufacture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Four separate presentations given by:
- Prof Nikos Donos, Head of the Clinical Oral Research Center at the Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London (QMUL) in collaboration with SJ Russell.
- SJ Russell (Leeds)
- P Giannoudis (Leeds)
- M. Mehr (Geistlich Pharma AG)
Year(s) Of Engagement Activity 2018
URL http://mede-innovation.ac.uk/event/mede-innovation-ask-expert-oct-18/
 
Description Ask the Researcher - Patient Involvement group meeting (Chapel Allerton Hospital, Yorkshire) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Short talk to a patient group focussed on communicating the research of the iMBE ankle research group. Two events were run (lunch time and evening) with approximately 25 patients and interested general public. There was much interest in our research area, and several patients had ankle problems or total ankle replacement. It was hoped there would be some engagement around informing future research directions, although it was clear the patients were less familiar with engineering research. Subsequently I have been awarded an internal engagement fellowship from the university specifically to develop stronger links with the ankle patient group, and to start a dialogue between the research group and patients to have better communication and understanding between the two.
Year(s) Of Engagement Activity 2016
URL http://lmbru.leeds.ac.uk/event/ankles-evening-event/
 
Description BEIS Humans of STEM Instagram 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BEIS launched a new social media channel on Instagram called Humans of Stem. A photo blog and highlight key projects with the aim of helping the public better understand what motivates researchers/academics/businesses, and how the complex projects they work on.
Year(s) Of Engagement Activity 2019
 
Description Back 2 the Future: Cells and Gels for LBP. C Le Maitre: Cafe Sceinctific - Scunthorpe 6th March 2019: Cells and gels for LBP. (POC057 SHU) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientific meeting in Scunthorpe 6th March 2019 on Cells and gels for LBP.
Year(s) Of Engagement Activity 2016,2019
 
Description Bio engineering event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact presentation and lab tour - number individuals contacted after saying had opened minds and asked for other info
Year(s) Of Engagement Activity 2019
 
Description British Orthopaedic Association (BOA) Annual Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Engagement of clinicians and industry
Year(s) Of Engagement Activity 2015
 
Description British Orthopaedic Research Society, Leeds 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Support provided for BORS 2018 - With over 600 members involved in research, this meeting will include a mixture of clinical and scientific sessions, with speakers from across the UK, showcasing the latest leading research going on in our laboratories and clinics.
Year(s) Of Engagement Activity 2018
URL https://www.imbe.leeds.ac.uk/bors-2018/
 
Description C Le Maitre: Manchester SciBar public talk 29th Nov 2018 (POC057 SHU) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact public talk on research related to POC project
Year(s) Of Engagement Activity 2018
 
Description Cafe Scientific - Scunthorpe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Café scientific presentation discussing the research and the reasons for low back pain.
Year(s) Of Engagement Activity 2019
 
Description Cartilage and Osteoarthritis Workshop - Focus on Imaging reservation University of Exeter, 18 Spetember 2018; Dr Jay Dudhia Chair by invitation (POC041 J Dudhia) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Cartilage and Osteoarthritis Workshop - Focus on Imaging
Year(s) Of Engagement Activity 2018
 
Description Clinical Focus Group (Sidney POC064) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Clinical focus group held at QVH in East Grinstead.
Year(s) Of Engagement Activity 2018
 
Description Digital Health Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact The workshop will explore unmet needs in self-monitoring and managing long term health conditions (asthma, diabetes, COPD), and will focus on developing initial solutions to address the identified unmet needs. Following the workshop, the Translate team will support project teams in progressing their ideas by providing: initial funding, access to expertise, extra clinical/NHS input, project development planning, support with further investment etc.

The workshop provides the opportunity for healthcare professionals, NHS/CCG representatives, academics, companies, and sufferers of long term health conditions to co-develop solutions which respond to real national health needs.
Year(s) Of Engagement Activity 2016
 
Description Digital Healthcare Revolution: Harnessing NHS Technology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact At the Digital Healthcare Revolution: Harnessing NHS Technology conference we will discuss the role that technology and data is already playing within the NHS and how future digital innovation will enable the changing landscape of the health and social care system. The speaker programme of leading experts will share knowledge and exchange opinion on how the progressive and sustained use of digital technologies can benefit a transformed healthcare system. With vertical integration an ambition across the NHS and social care there will be an opportunity to examine how paperless information can be shared appropriately and safely to the benefit of patients and staff. We will showcase a number of initiatives and examples of best practice from throughout the health and social care system and there will be ample opportunity for interactive discussion and networking amongst fellow professionals and peers.
Year(s) Of Engagement Activity 2016
 
Description Early Career Researcher 2 day residential 'Sandpit' workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact This 2 day workshop was a forum for Early Career Researchers (ECR) to discuss and share potential research opportunities with a view to pitching for £5000 (FEC) funding from MeDe Innovation to undertake the chosen projects. Projects had to be a collaboration between at least two Universities/companies.

ECR's were also given presentations on various aspects of professional development, such as grant writing and IP.

At the end of the two days, the ECR's pitched ideas to a panel of industry and academic MeDe members and 2 projects were awarded funding to progress.
Year(s) Of Engagement Activity 2016
 
Description European Inventor of the Year Announcement 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Website article highlighting the nomination of Eileen Ingham and John Fisher for the EU Inventor of the Year prize in 2018.
Year(s) Of Engagement Activity 2018
URL http://medical-technologies.leeds.ac.uk/news-post/john-fisher-and-eileen-ingham-shortlisted-for-an-i...
 
Description Explore event - 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact explore event in Sheffield, aimed principally at children but wide audience, lots of follow up contacts and questions.
Year(s) Of Engagement Activity 2019
 
Description Explore event Sheffield 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presented within the Sheffield Explore event discussing the research funded by the MRC and sparked lots of interest into what research is undertaken.
Year(s) Of Engagement Activity 2018
 
Description Festival of Ideas 2018 (Southgate POC045) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Festival has mostly free events, including talks, performances, exhibitions and family-friendly activities, the Festival delivers an exciting and diverse programme for all ages.
Year(s) Of Engagement Activity 2018
URL http://yorkfestivalofideas.com/2018/
 
Description HTCF National Conference Students in Healthcare Innovation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Healthcare Technologies Co-operative Foundation. Speakers included
- Professor Mike Raxworthy, Operations Director of the Regener8 Centre for Translational Regenerative Medicine, Institute of Medical and Biological Engineering, Uni of Leeds.
Year(s) Of Engagement Activity 2017
URL https://leeds.tech/event/htc-foundation-national-conference/
 
Description Healthcare Review 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Bridging the Med Tech Innovation Valley of Death - Professor John Fisher, CBE, University of Leeds
24/11/2016
Year(s) Of Engagement Activity 2016
 
Description Hosted laboratory visit for Leeds Biomedical Research Centre Patient Public Involvement group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Hosted a laboratory tour and series of talks from academic members of the Institute of Medical and Biological Engineering for members of the Leeds PPI group
Year(s) Of Engagement Activity 2018
URL https://youtu.be/cKfs50-NxJQ
 
Description IKC Annual Conference 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The conference brings together the IKC's network of academics, industrialists, clinicians and regulatory body representatives through lively presentations and active networking. Sessions include:
Updates from our most successfully translated projects
Presentations from our partner programmes, including funding opportunities available
A dedicated Early Career Researcher session discussing career paths
Year(s) Of Engagement Activity 2019
 
Description IKC E-Shot Regener8 IKC Annual Conference - Call for community sourced session 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IKC-Regener8 requesting a call for 'community sourced' session presentations, developing new relationships and profiling the lastest research within the Med Tech industry. The impact of this E-shot provided applications for submission and review.
Year(s) Of Engagement Activity 2016
 
Description IKC E-shot rowdsourcing Competition + ARUK Call Sent on 16 May 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact E-shot promoting two translational funding competitions supported by the IKC, including Arthritis Research UK Translational Proof of Concept Funding and IKC ranslational Feasibility Fund.
Year(s) Of Engagement Activity 2016
 
Description IKC E-shot Crowdsourcing Competition, Sent on 6 Apr 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IKC E-shot promoting the IKC led Crowdsourcing Competition, Funding for Feasibility Studies, offering three university-based researchers a chance to have a feasibility study funded (up to £10,000 per study) and supported by professionals in research translation.
Year(s) Of Engagement Activity 2016
 
Description IKC Industry Partnership Call Industry Final Wave 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Engaged a total of 1,054 IKC contacts promoting the IKC Translational POC industry partnership call.
Year(s) Of Engagement Activity 2017
URL http://medical-technologies.leeds.ac.uk/current-call/apply-for-translational-proof-of-concept-fundin...
 
Description IKC Industry Partnership Call Industry Reminder Sent on 3 Nov 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact E-shot sent on 3 Nov 2016 to 134 industry unique subscribers to promote the IKC Industry POC.
Year(s) Of Engagement Activity 2016
URL http://medical-technologies.leeds.ac.uk/current-call/apply-for-translational-proof-of-concept-fundin...
 
Description IKC Newsletter including funding digest September 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Our newsletter features 6-8 of our key news items/events over a three month period, and is circulated to our entire contacts list and also pushed out via the website, twitter and LinkedIn pages. The content included promotion for the upcoming IKC-Regener8 conference, IKC POC funding calls and partner news.
Year(s) Of Engagement Activity 2016
 
Description IKC POC Briefing Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Academics and researchers working in close collaboration with medical technology industry partners can apply for £100,000 FEC from the Medical Technologies IKC to undertake proof of concept projects in Regenerative Medical Devices & Medical Devices with Enhanced Regenerative Functions. - See more at: http://medical-technologies.leeds.ac.uk/event/ikc-translational-proof-of-concept-awards-briefing-launch-and-qa/#sthash.DMSSCXC8.dpuf
Year(s) Of Engagement Activity 2016
 
Description IKC POC0053 - Mock-up presented to Lay Panel 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Progress report presented to Lay Panel (18 Oct 2018). Demonstration of mock-up of automated vertebral fracture identification tool. Positive reception.
Year(s) Of Engagement Activity 2018
 
Description IKC POC0053 - Mock-up presented to Radiologists 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Mock-up of automated vertebral fracture identification tool presented to Radiologists (Dr Sarah Gowlett) in Sheffield
Year(s) Of Engagement Activity 2018
 
Description IKC POC0053 Interviews with Clinicans from MBC 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Interviews with clinicians from MBC
Dr Peel - 24.10.17
Prof Eastell 5.12.17
Regular MBC doctors meeting 11.12.17
Year(s) Of Engagement Activity 2017
 
Description IKC POC0053 Sheffield lay Advisory panel 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Lay Panel introduced to the project - automated vertebral fracture identification tool (20.04.2017) and progress report presented (19.10.17)
Year(s) Of Engagement Activity 2017
 
Description IKC Regener8 Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Featuring world-class speakers, oral and poster presentation sessions and interactive panel discussions, the Regener8 Annual Conference 2016 will provide an excellent opportunity to disseminate, share and discuss the impact of university-industry collaborations in the field of regenerative therapies and medical technologies.
Sessions include:
• High calibre, international keynote speaker
• Accelerating the development of regenerative devices nationally - presentations from our national partners on their proof of concept projects
• Sharing our expertise with other providers - presentations from our Arthritis Research UK funded projects
• Question panels
• Networking time, including poster presentations from our Early Career Researcher community
• Value delivered - presentations from our partners that have successfully delivered IKC POC projects that are progressing closer to clinic and the market
Community showcase: presentations from the community that are submitted, selected and delivered by you, the Regener8 and UK med tech community
Year(s) Of Engagement Activity 2016,2017,2018
 
Description IKC Translational Feasibility Fund E-Shot Sent on 27 May 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact The Medical Technologies Innovation and Knowledge Centre (IKC) is partnering with Leeds University Business School to open a medical technologies innovation competition to support early stage translational research. E-shot sent to relevant IKC contacts to promote the call.
Year(s) Of Engagement Activity 2016
 
Description IKC-Regener8 Annual Conference - Call for community sourced session 24 Jan 2017 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Sent on 24 Jan 2017 to 1,078 unique subscribers to source presentations for the IKC-Regener8 Annual conference 2017.
Year(s) Of Engagement Activity 2016
 
Description IKC-Regener8 E-Shot Your chance to present at Regener8/IKC conference 2016, Sent on 26 Feb 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact IKC-Regener8 requesting a call for 'community sourced' session presentations, developing new relationships and profiling the lastest research within the Med Tech industry. The impact of this E-shot provided applications for submission and review.
Year(s) Of Engagement Activity 2016
 
Description Impact Event - 18 November 2015 'Investing in Knowledge - creating opportunity' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The event will:
1) Evidence the scale and breadth of the University's contribution at a national and international level and to demonstrate how this translates into the contribution made to the economy of the City Region (in both absolute and proportionate terms) using a specially commissioned piece of research

• Demonstrate tangible examples of the breadth of the University's impact using selected examples of both current and past activity, accessible for a non-academic audience and in so doing positively impact perceptions of the University's scale, breadth and excellence

• Showcase specific examples of major new initiatives designed to increase the University's future impact, with the focus being at a regional level (but making it clear that these are nationally and internationally significant activities) - examples would include the North East Quarter, the Academic Health Partnerships, the Cultural Institute and the University Innovation and Enterprise Centre (UIEC);

• Set this in the context of the University's strategic ambition

• Showcase broader University and campus developments including the campus master plan

2. The event will be positioned as the first of a series of activities that will form a coherent strategy for external stakeholder engagement designed to increase the effectiveness with which the University engages with key stakeholders on a City, regional, national and international basis.

Desired Outcomes:
To positively impact existing perceptions of key stakeholders so that they gain a sense of the scale, substance and breadth of the University's relative contribution to the region set in the context of its national and global impact.

Internationally significant work has a direct regional relevance and impact. This in turn should help support the University and the City and region to work together to maximise the opportunities for funding designed to support local and regional economic growth.
Year(s) Of Engagement Activity 2015
 
Description Innovate 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The global spotlight on UK innovation including attendance from over 3,000+ of the UK's most exciting innovators, international investors and buyers, government and academia. Presentations outlined the importance of innovation, which is closely alligned to the work carried out by Medical Technoloiges IKC.
Year(s) Of Engagement Activity 2015
 
Description Invited Talk to HYMS Medtech Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Jenny Southgate was invited to attend and give a talk at the HYMS Medtech Society meeting.
Year(s) Of Engagement Activity 2018,2019
 
Description Invited talk at Biomaterials Symposium organised by Lancaster University (McCarthy POC068) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Project outputs presented during an invited talk at Biomaterials Symposium organised by Lancaster University
Year(s) Of Engagement Activity 2018
 
Description Invited talk at European Society for Paediatric Urology (Southgate - POC045) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited talk at the European Society for Paediatric Urology in Harrogate in 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited talk to John Hopkins University (Southgate - POC045) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited to talk at John Hopkins University
Year(s) Of Engagement Activity 2018
 
Description Invited talk to Oxford University (Southgate - POC045) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited talk to Oxford University.
Year(s) Of Engagement Activity 2018
 
Description JDH Talk at Leeds MedTech and Personalised Medicine - London Showcase 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Jo Dixon-Hardy; Director - Medical Technology Innovation talk titled Connecting capability to support the commercialisation of tomorrow's MedTech products.
Year(s) Of Engagement Activity 2018
URL http://leeds-medtech-and-personalised-medicine.eventcreate.com/
 
Description MEIbioeng15 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The purpose of this workshop, held as part of the annual Medical Engineering Initiative (MEI) meeting, was to gather a diverse group of over 30 different stakeholders to discuss the opportunities and challenges of advancing knowledge and technology in the field of medical engineering and technology. Specifically, this MEI workshop chose to focus on the medical engineering landscape and the opportunities and challenges faced in the advancement of knowledge and technology and the translation of research. Over 30 people representing industry, the health service, regulators, investors, funders and academia participated in the workshop discussions.
Year(s) Of Engagement Activity 2015
 
Description Magazine article - Why get a filling when you could print a new smile? 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Online article in Horizon - The EU Research & Innovation Magazine
Year(s) Of Engagement Activity 2018
URL https://horizon-magazine.eu/article/why-get-filling-when-you-could-print-new-smile.html
 
Description Manufacturing Technologies Association - UK Manufacturing Review Book Launch 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A published book containing an overview of the current centres of manufacturing within the UK (across all disciplines).
Year(s) Of Engagement Activity 2015
 
Description MeDe Innovation Annual Conference 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact the conference will report on progress and advances in research, innovation, and translation of its three focus areas: New approaches to manufacturing at the point of need Manufacturing regenerative devices, biological and biomimetic scaffolds Stratified design and manufacture of orthopaedic implants The conference will include presentations and posters from industry, regulators clinicians and academic researchers, panel discussions, poster pitches and networking opportunities.
Year(s) Of Engagement Activity 2017
URL http://mede-innovation.ac.uk/event/mede-innovation-fourth-annual-conference/
 
Description MeDe Innovation Annual Review 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Glossy review of annual activity of the MeDe. Disseminate, share and discuss the impact of university-industry collaborations in the field of regenerative therapies and medical technologies. Includes case studies of MeDe projects, and funder metrics such as funding leveraged, numbers of people engaged, partners and collaborators.
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description MeDe Innovation Conference (Newcastle) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact the conference will report on progress and advances in research, innovation, and translation of its three focus areas:

New approaches to manufacturing at the point of need
Manufacturing regenerative devices, biological and biomimetic scaffolds
Stratified design and manufacture of orthopaedic implants

The conference will include presentations and posters from industry, regulators clinicians and academic researchers, panel discussions, poster pitches and networking opportunities.
Year(s) Of Engagement Activity 2016
 
Description Med Tech Skills Academy Announcement 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Website article announcing the launch of the National MedTech Skills Academy, a partnership between educational institutions and medical technologies companies in the Leeds City Region.

It will act as a centre of expertise with an industrial advisory group helping identify the key skills needed at all levels, from technicians to PhD design.

The Academy consortium, including Leeds Beckett University and Bradford College, builds on a number of key existing strengths including the Leeds Academic Health Partnership and the Translate: Medical Technologies partnership
Year(s) Of Engagement Activity 2018
URL https://engineering.leeds.ac.uk/news/article/20034/faculty-of-engineering/436/leeds-to-establish-the...
 
Description Medical Technologies IKC Annual Review 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Glossy review of annual activity of the MTIKC, launched to coincide with the annual IKC/Regener8 conference. Disseminate, share and discuss the impact of university-industry collaborations in the field of regenerative therapies and medical technologies. Includes case studies of POC projects, and funder metrics such as funding leveraged, numbers of people engaged, partners and collaborators.
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description Medical Technologies Science Fair - How to Engineer a Human - Leedc City College 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Exhibit and short talks at the Medical Technologies Open Day event at Leeds City College - in conjunction with numerous medical technology companies in the region to showcase what is going on in Leeds. Open to the general public and school/college students over the day - approximately 150 attendees in total.
Year(s) Of Engagement Activity 2017
URL https://leeds.tech/event/how-to-engineer-a-human-2/
 
Description Medilink Healthcare Business 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This prestigious event celebrates excellence in the medical technology and healthcare sectors from across Yorkshire and the Humber. It gives local companies the opportunity to celebrate their ongoing commitment to world-class quality and excellence.

The event is a showcase for the region and the diverse sector covering medical technologies, healthcare technology and related life sciences right across the region from Sheffield to Leeds to York and Hull.

The Medical Technologies IKC presented the Skills Award.
Year(s) Of Engagement Activity 2016
 
Description Medipex Innovation Awards 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Medipex NHS Innovation Awards bring together the most innovative & exciting people from the region's NHS & commercial healthcare sector. Over 12 years, the event has established a reputation for showcasing outstanding projects and initiatives from across Yorkshire, Humber and East Midlands regions, providing a unique insight into up and coming new innovations and thinking from the NHS.
We are delighted to be able to offer the opportunity for a small number of Companies to be involved. Sponsorship allows organisations be directly associated with the NHS innovation agenda and offers significant publicity opportunities. Attendance at the awards event also provides a unique opportunity to network with key NHS and healthcare business leaders.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Mellanby Bone Imaging and Modelling Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Workshop held at Inox Conferencing Suite at University of Sheffield. Speakers on Bone Imaging for Fracture Prediction (Hip and Vertebral), Peripheral Imaging, Monitoring Treatment Effects on Bone.
Year(s) Of Engagement Activity 2017
URL https://medicine.dept.shef.ac.uk/news/index.php/2017/04/19/mellanby-bone-imaging-and-modelling-works...
 
Description Ministerial visit 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article about Lord Pryor's visit to iMBE. Government Health Minister Lord Pryor met iMBE Director Professor Ruth Wilcox, heard an extensive presentation from Professor Paul Emery. He was shown the operation of the Leeds IKC and visited iMBE laboratory facilities to view the technical equipment used to produce world-leading research results.
Year(s) Of Engagement Activity 2016
 
Description National Centre for Universities and Business (NCUB) Case studies - DePuy 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The fourth annual report on the State of the Relationship between universities, business and policy makers, highlighting the partnership between the University of Leeds and DePuy Synthes.

The annual report provides strong examples of university business partnerships with updated metrics on progress in collaboration between universities, business and government
Year(s) Of Engagement Activity 2017
URL http://medical-technologies.leeds.ac.uk/news-post/state-of-the-relationship-report-2017-highlights-l...
 
Description Now is the time to invest in medical technologies sector 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview with Professor John Fisher, Director of the Institute for Medical and Biological Engineering, University of Leeds, about pioneering research in the fields of medical devices and regenerative medicine
Year(s) Of Engagement Activity 2018
URL http://www.opnews.com/2018/01/now-time-invest-medical-technologies-sector/14260
 
Description Orthopaedic Knee Conference 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This scientific meeting will aim to tackle current trends
and topics as well as raise future surgical concepts and
innovations. The one-day meeting will discuss topics
including NJR / Beyond Compliance issues, Total knee
arthroplasty and sessions on uni-knee replacement and soft
tissue. It promises to be a highly stimulating event and a
great educational resource for all delegates.
Year(s) Of Engagement Activity 2016
URL http://www.opnews.com/programme
 
Description Otley Science Fair 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Exhibition at Otley Science Fair showcasing research undertaken around medical technology.
Approx 600 members of general public engaged with stall - questions from many including patients and school children who may consider future career in engineering.
Year(s) Of Engagement Activity 2018
URL https://otleysciencefestival.co.uk/festival/
 
Description PPE Bradford 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact • To provide a technical focus for the polymer processing and technology industries
• To discuss key developments in engineering excellence in polymer processing
• To discuss recent developments in Advanced Materials in Healthcare and Medical Devices (focusing on MeDe Challenge 2, MeDe presentations are integral to this meeting)
• To raise awareness of leading edge developments in polymer processing technology, in-process measurements and process flow modelling, and control
Year(s) Of Engagement Activity 2015
 
Description PPI ask the researcher event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact PPI group presentation on research, also lead to number of patients joining local patient user group
Year(s) Of Engagement Activity 2019,2020
 
Description Patient Engagement Visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Visit by 35 members of the Patient and Public Involvement group at Chapel Allerton Hospital to the Institute of Medical and Biological Engineering at the University of Leeds.
Day included short overview presentations from academics involved with musculoskeletal research (5 talks) and tours around the laboratories with demonstrations. Tours provided by PGR students, who had received training in engagement.
Discussion afterwards highlighted interest of patients in our research and enabled a conversation to be held about the type of work IMBE does. Follow up visits themed around specific researc areas are planned for the future (e.g. knee programme grant focus).
Year(s) Of Engagement Activity 2018
URL http://leedsbrc.nihr.ac.uk/event/ask-researcher-institute-biomedical-engineering/
 
Description Patient USer Feedback Group 08/03/19 (POC057 Sammon Le Maitre SHU) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Patient engagement to understand clinical need, seek input and advice from patients on the need, application and use of the SNIPER technology to treat chronic back pain
Year(s) Of Engagement Activity 2019
 
Description Patient group Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Patient User group meeting discussion of need for new therapies for low back pain and discussing current research plans
Year(s) Of Engagement Activity 2019
 
Description Presentation at ERAS conference, Liverpool, June 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk by David Jayne titled 'Does new technology improve surgical outcomes?'
Year(s) Of Engagement Activity 2019
 
Description Presentation at European Eye Bank Association Conference (Hanover, January 2020) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation titled 'A novel preservation technique for long-term storage and ambient distribution of transplantable human corneas'
Year(s) Of Engagement Activity 2020
 
Description Presentation at Nottingham Eye Symposium (Nottingham, January 2020) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation titled 'A novel preservation technique for long-term storage and ambient distribution of transplantable human corneas'
Year(s) Of Engagement Activity 2020
 
Description Presentation of Research Methods - NI Science Festival 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Research methods used during this project were presented to pupils visiting the university lab facilities (NI Science Festival 2020)
Year(s) Of Engagement Activity 2020
 
Description Presentation of Research Methods - Soapbox Science 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Research methods used during this project were presented to the general public during SopabBox Science 2019
Year(s) Of Engagement Activity 2019
 
Description Presentation of Research Methods - Versus Arthritis 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Research methods used during this project were presented to volunteers working with Versus Arthritis
Year(s) Of Engagement Activity 2019
 
Description Regen - Regener8 Annual Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Glossy review of annual activity of the Regener8 programme. Review sponsored by the MTIKC
Year(s) Of Engagement Activity 2014,2015,2016
 
Description Regener8 IKC Annual Conference - Call for community sourced session 20 Dec 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact E-shot sent on 20 Dec 2016 to 1,083 unique subscribers to source community content for the IKC-Regener8 Conference 2017
Year(s) Of Engagement Activity 2016
 
Description Regener8-Medical Technologies IKC Annual Conference Sent on 26 May 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact E-shot to promote the IKC-Regener8 conference 2016, showcasing the support and contributions the IKC team have made to projects.
Year(s) Of Engagement Activity 2016
 
Description Regenerative Devices Industry Partnership Call (Academic Target) Sent on 16 Sep 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact E-shot sent on 16 Sep 2016 to academic unique subscribers to promote the IKC Industry POC.
Year(s) Of Engagement Activity 2016
 
Description Regenerative Devices Industry Partnership Call (Industry Target) Sent on 16 Sep 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact E-shot sent on 16 Sep 2016 to industry unique subscribers to promote the IKC Industry POC.
Year(s) Of Engagement Activity 2016
 
Description Regulatory Affairs for Medical Devices 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Translate: Me - workshop held on 16/01/2018. This workshop provides an introduction to the regulatory requirements for placing medical devices on the market. It will help participants to understand the regulatory pathway to CE marking a device. As well as guiding delegates through the Medical Device Directive, this workshop will also provide information about other relevant guidance, standards and the new Medical Device Regulations
Year(s) Of Engagement Activity 2018
URL http://www.translate-medtech.ac.uk/events/regulation-for-medtech/
 
Description Rehabilitation for Medical Technoloiges Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This workshop provides an opportunity for clinicians and patients to engage with academics and companies to discuss new and novel ways to address unmet needs in the area of rehabilitation.

We will define the challenges facing us, explore unmet clinical needs and patient priorities, form multidisciplinary teams to develop new interesting patient focused solutions and refine ideas into potential project opportunities that can be further supported and progressed in conjunction with the Translate team.
Year(s) Of Engagement Activity 2016
 
Description Research professional - ARUK POC announcement 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Continuing collaboration with ARUK (now Versus Arthritis) Opportunity profile: Getting medical devices to market - Proof of Concept Call:
Researchers with solid ideas for medical devices for any musculoskeletal condition can apply for £100,000 and business coaching
Year(s) Of Engagement Activity 2017
 
Description SMART Medical Devices Conference, Berlin 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A unique knowledge-sharing platform around the best practices in discovery, development and innovation of medical devices technology.
Year(s) Of Engagement Activity 2015
 
Description School Visit Engagement (McCarthy POC068) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Research methods used during this project were presented to pupils visiting the university lab facilities
Year(s) Of Engagement Activity 2018
 
Description School visit to deliver seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Education of sixth form children about strategies in regenerative medicine with a focus on regenerative devices
Year(s) Of Engagement Activity 2017
 
Description Science Cafe Talk at Otley Science Cafe (Yorkshire) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Short talk at Otley Science Café based on biomechanics to 50+ members of the general public - ranging from 13 year old student to a group of 70yr +.
Many questions following my talk, and contact from the University of the Third Age following the event to arrange a visit and a talk at the research institute.
Year(s) Of Engagement Activity 2015
 
Description Science Fair Stall - Otley Science Fair, Yorkshire 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Hands-on activities for children, parents and general public designed to highlight research undertaken within the Institute of Medical and Biological Engineering, and more broadly demonstrate what a bioengineer does. Good level of engagement with activities, many adults spent a long time at the stand discussing the research in more detail. Feedback captured by the Otley Science Fair team highlighted there was a lot of interest in our stand and it had highlighted a research area most were unaware of.
Year(s) Of Engagement Activity 2016
 
Description Science and Innovation Audit published - Medical Technologies in the Leeds City Region 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Science and Innovation Audit, commissioned by the Department of Business, Energy and Industrial Strategy (BEIS), highlighting investment opportunities for medical technologies.

Led by Professor John Fisher from the University of Leeds, in partnership with the Leeds Enterprise Partnership (LEP), the region's universities and local businesses.
Year(s) Of Engagement Activity 2017
URL https://medical-technologies.leeds.ac.uk/news-post/science-and-innovation-audit-published/
 
Description Science week 2019 school session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact In School session during science week, sparked questions and discussion afterwards, raised awareness of research and stem cells.
Year(s) Of Engagement Activity 2019
 
Description Science week TED style talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public presentation to wide audience, lots of interest from the audience and a clinician in the audience is interested in alternative uses for the hydrogel
Year(s) Of Engagement Activity 2019
 
Description Sector deal recognition 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Website article highlighting how research into innovative medical technologies, spanning the Faculties of Engineering and Biological Sciences, has been recognised in the Government's Industrial Strategy Life Sciences Sector Deal.
Year(s) Of Engagement Activity 2017
URL https://engineering.leeds.ac.uk/news/article/20034/faculty-of-engineering/428/government-recognition...
 
Description Seminar to the Equine Veterinary Medicine Centre (Qatar Foundation), Doha, Qatar, "Label free imaging of articular cartilage" 17 October 2018 (POC041 J Dudhia) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Seminar on label free imaging of articular cartilage
Year(s) Of Engagement Activity 2018
 
Description Sheffield ARUk Hydrogels project 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Online article about work at Sheffield Hallam University - the development of a range of revolutionary hydrogels that may remedy degenerative disc disease
Year(s) Of Engagement Activity 2017
URL https://www4.shu.ac.uk/mediacentre/scientists-test-potential-new-cure-back-pain?filter=Health
 
Description Speaking at NIPE Screening Programme Conference 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Public Health England - NIPE Screening Programme Conference 2019. Speaking in generalities
Year(s) Of Engagement Activity 2019
 
Description State of the City Meeting - The Future of Manufacturing 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Medical technology - bringing together precision engineering with healthcare - is a field where Leeds has some world leading companies. We also have, in the University of Leeds, one of the country's leading research institutions in engineering and health. This workshop explores the possibilities that this sector brings, focussing on DePuy and Brandon Medical, two Leeds-based companies with global reputations, and on the University's research excellence. The speakers will describe the kind of work that is involved in medical technology innovation, and the sector's role in the future of the city.
Year(s) Of Engagement Activity 2012,2015
 
Description TI World Conference Programme - Keynote 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote presentation on textile medical devices and healthcare to the World Textile Institute Conference
Year(s) Of Engagement Activity 2018
URL http://www.tiworldconference.org/wp-content/uploads/2015/04/TIWC-2018-Programme-Final1.pdf
 
Description TOKA website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Website to advertise, publicise and educate clinicians and the public about the new technology in development
Year(s) Of Engagement Activity 2018
URL https://www.toka.org.uk/
 
Description TV Interview for Clinical Researcher working on project (Southgate - POC045) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Debora (the researcher on the POC project) has given a TV interview to journalist from That's TV York.
Year(s) Of Engagement Activity 2018
 
Description Termis - Americas 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tronci G; Liang H; Wood DJ; Russell SJ (2017) Functionalised Collagen Systems With Bespoke Molecular And Macroscopic Characteristics For Chronic Wound Management 2017 TERMIS - Americas Conference & Exhibition, pp. S74-S74. Charlotte, NC
Year(s) Of Engagement Activity 2017
 
Description Translate Digital Health Workshop with Regener8 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This workshop was organised in partnership with Regener8 (The UK Regenerative Devices community) and DHEZ (the Digital Health Enterprise Zone), and was designed to identify and address unmet needs in the self-management and monitoring of long term health conditions. The workshop was professionally facilitated by Tim Morley from KnowInnovation.

• To identify and discuss the current state of the sector, and identify high priority unmet needs.
• To facilitate multi-institutional and multi-disciplinary collaboration between people working on or are interested in working on digital solutions for the self-management and monitoring of long term health conditions.
• To develop and explore potential solutions to address the identified unmet needs.
• To form collaborative multi-disciplinary teams interested in developing ideas into future project opportunities with support from the Translate team and input from Regener8.
Year(s) Of Engagement Activity 2016
 
Description Translate Rehabilitation for Medical Technologies Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This particular workshop was hosted by Translate in partnership with Regener8 and Devices for Dignity Health Technology Cooperative (D4D HTC). It was designed to identify and address unmet needs in Rehabilitation through medical technologies. The workshop was professionally facilitated by Tim Morley from KnowInnovation.

The specific aims of the workshop were:
· To identify and discuss the current challenges within rehabilitation, and identify high priority unmet needs.
· To facilitate multi-institutional and multi-disciplinary collaboration between people working on, or are interested in working on, medical technologies for rehabilitation.
· To develop and explore potential solutions to address the identified unmet needs.
· To form collaborative multi-disciplinary teams interested in developing ideas into future project opportunities with support from the Translate team and input from Regener8.
Year(s) Of Engagement Activity 2016
 
Description UK MedEnterprise Training Network, Imperial College London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Medical Technoloiges IKC attended the UK MedEnterprise Training Network workshop that aims to solidify and feed the medtech entrepreneurship ecosystem with networks will encompass everything from student training to full-scale medtech businesses. The workshop featured panel discussions, interactive sessions, and ample networking opportunities. One goal will be to provide exposure for the various university training programmes, and seek input from other constituents on programme content. There will also be featured elevator pitches from the emerging entrepreneurs that are an important output of these programmes.
Year(s) Of Engagement Activity 2016
 
Description UKRMP Immunomodulation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Key Focus
To discover how to harness the immune system for improved outcomes in regenerative medicine.

Aims and objectives:

Our collective knowledge and shared experimental tools will be used to answer three key questions in regenerative medicine;

1. How do differentiated cells signal to the host innate and adaptive immune system?

2. How do transplanted cells provoke adaptive immune responses?

3. How does the inflammatory niche contribute to endogenous repair and influence the fate of transplanted cells?

Key translational challenges to be addressed:

The central goal of regenerative medicine is to replace damaged or diseased tissue. This can potentially be achieved by stimulating endogenous tissue repair or by transplanting autologous or allogeneic cells. No matter which strategy is taken, host immune responses can represent a formidable obstacle to success. Unless autologous cells are used, transplanted cells will have different degrees of major histocompatibility antigen (MHC) mismatch with the recipient and will thus be at risk of rejection by the adaptive immune system. Even when donor and recipient are matched for the MHC, antigen-independent inflammatory pathways (the innate immune system) modulate endogenous repair and can hinder donor cell engraftment. By modulating different aspects of the immune system we intend to improve the efficacy of regenerative medicine therapies.

Expected outcomes:

Our long-term clinical deliverables include: improved efficacy of photoreceptor cell therapy to treat blindness; improved repair of damaged heart tissue; and improved survival and functionality of transplanted hepatocytes as an alternative to liver transplantation.
Year(s) Of Engagement Activity 2015
 
Description Unmet needs workshop - Leeds 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Workshop identifying unmet needs - contribution lead to strategy development.
Year(s) Of Engagement Activity 2019
 
Description Versus arthritis user group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact patient user group meeting - discussed research areas and patient input, very engaged audience with lots of questions.
Year(s) Of Engagement Activity 2020
 
Description West Yorkshire Economic Growth Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Exhibited Translate: at WYEGC. A day of discussion and opportunity for our region's business public sector leaders.

Sponsorship included
• Prime branding on the badges worn by all delegates
• 3m2 Stand space (stand build additional) in the Exhibition area.
• 5 Delegate passes for the conference.
• Your logo will be displayed on the front page of the website.
• Your logo will be on all documents related to the event - booking forms, emails etc.
• One half page advert in conference programme.
• Access to photographs and video of the event.
Year(s) Of Engagement Activity 2017
URL https://www.built-environment-networking.com/event/west-yorkshire-development-event/
 
Description http://medical-technologies.leeds.ac.uk/news-post/heart-device-on-trial-that-could-save-the-nhs-200-million-a-year/ 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Article promoting a new cardiac scanning device that could save the NHS £200 million a year, being trialled at four of the UK's largest emergency departments (Bristol, Nottingham, Leicester and Sheffield).
Year(s) Of Engagement Activity 2017
URL http://medical-technologies.leeds.ac.uk/news-post/heart-device-on-trial-that-could-save-the-nhs-200-...