Smart Hybrid pH Responsive Coatings for Healthcare

Lead Research Organisation: University of Liverpool
Department Name: Chemistry

Abstract

This project is a collaboration between Boots (a leading Pharmacy, Health and Well Being company), the University of
Liverpool (a member of the Russell Group of Universities) and an innovative SME. The project aims to develop a smart
release technology to deliver ingredients on demand within a cosmetic delivery system for a healthcare application. The
University of Liverpool will provide specific expertise in the smart release components and advanced spectroscopic and
imaging characterisation, and the SME will provide materials expertise. Boots provide both a potential route to market and
an extensive knowledge of the market and application area.

Planned Impact

The academic PI at the University of Liverpool (UoL), in coordination with the industrial partners, will progress impactrelated
development and opportunities, as outlined below.

1. Industrial and Healthcare Impact
Results of wider significance to technology, healthcare, formulation technology and society will be assessed by the project
partnership and, when appropriate, be disseminated to stakeholders such as industry, government and public bodies via
dedicated pathways supported by the 'Open Innovation Hub in Antimicrobial Surfaces' located at the Surface Science
Research Centre at the University of Liverpool and headed by the academic PI. The Innovation Hub provides conduits into
a large pool of SMEs, the Liverpool Local Enterprise Partnership (LEP), Medilink, BioNow, Knowledge Transfer Networks
(KTNs) and Regulatory experts via Networking events, Industry Days and Training Workshops. UoL's Business Gateway
team will facilitate knowledge exchange and IP expertise. The Open Innovation Hub in Anti-Microbial Surfaces has also
entered into partnership with Liverpool Health Partners (LHP), representing 12 NHS trusts in Merseyside, which will foster
active engagement with NHS clinicians and dermatologists.
Dissemination: Technological and healthcare breakthroughs will be publicised, when appropriate, through: the press office
of University of Liverpool (UoL), which has direct links to the media and to all learned societies and professional bodies
(e.g. the Royal Society, the RSC, IoP, IoM, the BMA and the IoM); via the websites and publicity literature of the
collaborating companies; and, via dedicated publications such as 'Research Intelligence' by UoL, which is widely circulated
to industrial and public institutions. Project outputs, following appropriate IP protection, will be published in high impact
journals and presented at international conferences and trade meetings e.g. World Pharma congress, SCSFormulate,
Medica, American Chemical Science and Materials Research Science conferences, ECASIA and American Academy of
Dermatology conference.

2. Knowledge Transfer, IP and Exploitation
The outputs of the project will be scrutinised by the consortium partners for possible exploitation, patent protection and
commercialisation, aided by business development managers from each institution. The academic PI is the Head of
Knowledge Transfer at the School of Physical Sciences at Liverpool and, along with the host institution, is well geared in
matters of commercialisation and exploitation. The academic PI also has strong experience in engaging with the private
sector in her current role as Director of the 'Open Innovation Hub for Antimicrobial Surfaces' and her previous role as the
Associate Director of the 'Leverhulme Centre for Innovative Catalysis' at LU, both promoting active academic-industry R&D
collaboration programmes. She is also a member of a number of European research networks with active industrial
partnership from the fine chemicals and pharmaceuticals industry, and has secured international patents covering the EU,
US, China and Hong Kong from her previous research.
University Capability: The University of Liverpool is a member of the Russell Group and is strongly committed to staying at
the forefront of innovation and research. A considerable part of the University's research involves working with businesses,
and UoL has a long-established track record of impact resulting from research and strong cultures for Knowledge
Exchange activities. UoL topped the Russell Group in 2007 for income per academic from Knowledge Exchange, is the
best performer in Knowledge Transfer Partnerships in the northwest of England; and holds an EPSRC Knowledge Transfer
Account (KTA) to increase the Impact and Technology Readiness Level of EPSRC funded research. Faculty-assigned
business managers and specialist Legal Services and IP exploitation groups provide direct support to academics.

Publications

10 25 50
 
Description New application of smart materials for healthcare. Creation of smart, responsive interfaces.
Exploitation Route Non-academic: patent published.

Academic: Research papers to be published after IP secured.
Sectors Aerospace, Defence and Marine,Chemicals,Healthcare,Manufacturing, including Industrial Biotechology

 
Description Smart pH Responsive Materials that are applicable in healthcare and in anti-biofilm technologies.
First Year Of Impact 2017
Sector Aerospace, Defence and Marine,Chemicals,Healthcare,Manufacturing, including Industrial Biotechology
Impact Types Societal,Economic

 
Description KTN-NBIC Workshop on Biofilms and formal Report
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://admin.ktn-uk.co.uk/app/uploads/2018/05/Biofilm-Workshop-Report-May2018.pdf
 
Description BBSRC
Amount £12,500,000 (GBP)
Funding ID BB/R012415/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 12/2017 
End 11/2022
 
Description Innovate UK
Amount £668,000 (GBP)
Funding ID TS/N005600/1 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2016 
End 08/2018
 
Description Innovate UK
Amount £521,000 (GBP)
Funding ID TS/P004512/1 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2017 
End 02/2019
 
Description Innovate UK
Amount £350,000 (GBP)
Funding ID TS/P013716/1 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 04/2017 
End 09/2019
 
Description National Biofilm Innovation Centre 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution R Raval is the one the four academic co-directors who led a successful £12.5M BBSRC bid to create and launch an Innovation and Knowledge Centre (IKC) in Biofilms, named the National Biofilm Innovation Centre (NBIC). This initiative brings together a multidisciplinary team in physical and biological sciences from the Universities of Southampton, Liverpool, Nottingham and Edinburgh to tackle research challenges, innovation and training in the field of biofilms. My team brings in expertise in surface science, state of the art spectroscopic and imaging techniques, and the design of antimicrobial, anti-infective and anti-biofilm surfaces. Each lead university partner provides access data, equipment, facilities and researchers in order to pursue joint research collaborations. This is governed by a signed collaboration agreement between the universities.
Collaborator Contribution Each lead team from the Universities of Southampton, Liverpool, Nottingham and Edinburgh contributes: Expertise and intellectual input; Research Infrastructure; Researchers; Training facilities in order to roll out a national and international programme on research, innovation and training in the field of Biofilms. Together, the partners bring together £400M of infrastructure and a combined university commitment of £4M to support this initiative.
Impact Multidisciplinary collaborations between Life Sciences and Physical Sciences. Outputs: doi:10.3390/polym11121921; 10.1021/acsabm.9b00562;
Start Year 2017
 
Description National Biofilm Innovation Centre 
Organisation University of Nottingham
Department School of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution R Raval is the one the four academic co-directors who led a successful £12.5M BBSRC bid to create and launch an Innovation and Knowledge Centre (IKC) in Biofilms, named the National Biofilm Innovation Centre (NBIC). This initiative brings together a multidisciplinary team in physical and biological sciences from the Universities of Southampton, Liverpool, Nottingham and Edinburgh to tackle research challenges, innovation and training in the field of biofilms. My team brings in expertise in surface science, state of the art spectroscopic and imaging techniques, and the design of antimicrobial, anti-infective and anti-biofilm surfaces. Each lead university partner provides access data, equipment, facilities and researchers in order to pursue joint research collaborations. This is governed by a signed collaboration agreement between the universities.
Collaborator Contribution Each lead team from the Universities of Southampton, Liverpool, Nottingham and Edinburgh contributes: Expertise and intellectual input; Research Infrastructure; Researchers; Training facilities in order to roll out a national and international programme on research, innovation and training in the field of Biofilms. Together, the partners bring together £400M of infrastructure and a combined university commitment of £4M to support this initiative.
Impact Multidisciplinary collaborations between Life Sciences and Physical Sciences. Outputs: doi:10.3390/polym11121921; 10.1021/acsabm.9b00562;
Start Year 2017
 
Description National Biofilm Innovation Centre 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution R Raval is the one the four academic co-directors who led a successful £12.5M BBSRC bid to create and launch an Innovation and Knowledge Centre (IKC) in Biofilms, named the National Biofilm Innovation Centre (NBIC). This initiative brings together a multidisciplinary team in physical and biological sciences from the Universities of Southampton, Liverpool, Nottingham and Edinburgh to tackle research challenges, innovation and training in the field of biofilms. My team brings in expertise in surface science, state of the art spectroscopic and imaging techniques, and the design of antimicrobial, anti-infective and anti-biofilm surfaces. Each lead university partner provides access data, equipment, facilities and researchers in order to pursue joint research collaborations. This is governed by a signed collaboration agreement between the universities.
Collaborator Contribution Each lead team from the Universities of Southampton, Liverpool, Nottingham and Edinburgh contributes: Expertise and intellectual input; Research Infrastructure; Researchers; Training facilities in order to roll out a national and international programme on research, innovation and training in the field of Biofilms. Together, the partners bring together £400M of infrastructure and a combined university commitment of £4M to support this initiative.
Impact Multidisciplinary collaborations between Life Sciences and Physical Sciences. Outputs: doi:10.3390/polym11121921; 10.1021/acsabm.9b00562;
Start Year 2017
 
Description University of Pavia 
Organisation University of Pavia
Country Italy 
Sector Academic/University 
PI Contribution Surface Characterisation, Bacterial interactions with materials
Collaborator Contribution Providing specialist and characterised light-activated materials.
Impact Publications: doi:10.1038/s41598-017-05693-3 Multidisciplinary: Surface Science; Materials Science; Microbiology
Start Year 2016
 
Description University of Twente 
Organisation University of Twente
Country Netherlands 
Sector Academic/University 
PI Contribution Probing bacterial interactions at surfaces
Collaborator Contribution Providing specialist substrates
Impact Publications: DOI:10.1021/acsabm.8b00176
Start Year 2016
 
Title COSMETIC SKINCARE COMPOSITION 
Description A cosmetic composition and its use in the treatment of skin conditions, such as acne vulgaris. The composition may selectively remove free fatty acids (FFAs) from a subject's skinThe composition comprises 2 to 60wt% clay; 20 to 96wt% water; and 2 to 60wt% preservative. No more than 1% carboxylic acid compounds are present and the ratio of clay to carboxylic acid compounds is at least 90wt% clay: no more than 10wt% carboxylic acid compounds.The clay may be a 2:1 clay such as montmorillonite.The preservative may be an alcohol such as ethanol. 
IP Reference EP3563825 
Protection Patent application published
Year Protection Granted 2019
Licensed Commercial In Confidence
Impact Commercial in confidence
 
Description Dr Y Diaz presentation to the School of Physical Sciences 'Collaborative Research Workshop" 25th June 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Dr Y Diaz presentation to the School of Physical Sciences 'Collaborative Research Workshop" outlining the collaborative and multidisciplinary activities of the research group. This initiated cross-disciplinary discussions for future projects.
Year(s) Of Engagement Activity 2018
 
Description Invited Lecture at joint Innovate Uk and University of Liverpool's 'Making an Impact Week- Accelerating Impact through the Industrial Strategy' 11 June 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Invited Lecture at joint Innovate-UK University of Liverpool's 'Making an Impact Week- Accelerating Impact through the Industrial Strategy' showcasing the translation of research into innovation in areas of societal and industrial interest.
Raised profile of research and innovation of the University, with a number of follow-on interactions.
Year(s) Of Engagement Activity 2018
 
Description Invited presentation at the "In The Know" breakfast event on Infection and Disease at Liverpool Science Park, 30 Mar 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Invited presentation at the "In The Know" breakfast event on Infection and Disease at Liverpool Science Park, 30 Mar 2017 to highlight research and innovation in the region.
A number of interactions with regional institutes and national/global industry were initiated.
Year(s) Of Engagement Activity 2017
 
Description Invited presentation at the Big Infection Day- Developing our Interdisciplinary Infection Research 22 May 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited presentation at the Big Infection Day- Developing our Interdisciplinary Infection Research, with the aim to create cross-disciplinary thinking and partnerships to combat infection. This sparked discussions and initiated collaborations across different disciplines.
Year(s) Of Engagement Activity 2018
 
Description KTN- NBIC Workshop in Biofilms, 27 February 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A joint KTN- NBIC Workshop in Biofilms, 27 February 2018, to bring UK researchers and businesses in the field of Biofilms to identify major challenges in the field. A number of follow-on interactions and partnerships created and a formal report submitted by KTN to be considered for directing innovation and research strategy.
Year(s) Of Engagement Activity 2018
 
Description Launch of the National Biofilm Innovation Centre, The Royal Society London, 28th November 2017. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Official launch of the £26M National Biofilm Innovation Centre (NBIC), The Royal Society London, November 2017, as part of the the award of the BBSRC IKC and Government's Industry Strategy.
NBIC was launched to restructure Biofilms research and innovation in the UK and will drive a national agenda to this effect. It is led by the 4 co-leads:
Prof J Webb (U of Southampton); Prof R Raval (U of Liverpool), M. Camara (U of Nottingham) and C. MacPhee (U of Edinburgh) who represent a multi- and inter-disciplinary team.
Year(s) Of Engagement Activity 2017
 
Description Presentation at the Chemistry Industry Engagement Day 13 Sept 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Industry engagement day to showcase research and innovation within the department of chemistry, University of Liverpool.
This led to a number of follow-up interactions with industry,
Year(s) Of Engagement Activity 2018
 
Description Presentation to the Liverpool Enterprise Partnership Innovation Board 13 June 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Presentation on translation of research to innovation to the Liverpool Enterprise Partnership Innovation Board.
A number of follow-on interactions resulted.
Year(s) Of Engagement Activity 2018
 
Description Roadmapping workshop on Detection of Biofilms, Birmingham 24 Sept 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Organised workshop to road-map challenges in the detection of Biofilms.
A number of follow-on interactions resulted.
A formal report on the main outcomes is being produced and will inform policy.
Year(s) Of Engagement Activity 2018